/* Generated by Cython 0.29.14 */

#define PY_SSIZE_T_CLEAN
#include "Python.h"
#ifndef Py_PYTHON_H
    #error Python headers needed to compile C extensions, please install development version of Python.
#elif PY_VERSION_HEX < 0x02060000 || (0x03000000 <= PY_VERSION_HEX && PY_VERSION_HEX < 0x03030000)
    #error Cython requires Python 2.6+ or Python 3.3+.
#else
#define CYTHON_ABI "0_29_14"
#define CYTHON_HEX_VERSION 0x001D0EF0
#define CYTHON_FUTURE_DIVISION 1
#include <stddef.h>
#ifndef offsetof
  #define offsetof(type, member) ( (size_t) & ((type*)0) -> member )
#endif
#if !defined(WIN32) && !defined(MS_WINDOWS)
  #ifndef __stdcall
    #define __stdcall
  #endif
  #ifndef __cdecl
    #define __cdecl
  #endif
  #ifndef __fastcall
    #define __fastcall
  #endif
#endif
#ifndef DL_IMPORT
  #define DL_IMPORT(t) t
#endif
#ifndef DL_EXPORT
  #define DL_EXPORT(t) t
#endif
#define __PYX_COMMA ,
#ifndef HAVE_LONG_LONG
  #if PY_VERSION_HEX >= 0x02070000
    #define HAVE_LONG_LONG
  #endif
#endif
#ifndef PY_LONG_LONG
  #define PY_LONG_LONG LONG_LONG
#endif
#ifndef Py_HUGE_VAL
  #define Py_HUGE_VAL HUGE_VAL
#endif
#ifdef PYPY_VERSION
  #define CYTHON_COMPILING_IN_PYPY 1
  #define CYTHON_COMPILING_IN_PYSTON 0
  #define CYTHON_COMPILING_IN_CPYTHON 0
  #undef CYTHON_USE_TYPE_SLOTS
  #define CYTHON_USE_TYPE_SLOTS 0
  #undef CYTHON_USE_PYTYPE_LOOKUP
  #define CYTHON_USE_PYTYPE_LOOKUP 0
  #if PY_VERSION_HEX < 0x03050000
    #undef CYTHON_USE_ASYNC_SLOTS
    #define CYTHON_USE_ASYNC_SLOTS 0
  #elif !defined(CYTHON_USE_ASYNC_SLOTS)
    #define CYTHON_USE_ASYNC_SLOTS 1
  #endif
  #undef CYTHON_USE_PYLIST_INTERNALS
  #define CYTHON_USE_PYLIST_INTERNALS 0
  #undef CYTHON_USE_UNICODE_INTERNALS
  #define CYTHON_USE_UNICODE_INTERNALS 0
  #undef CYTHON_USE_UNICODE_WRITER
  #define CYTHON_USE_UNICODE_WRITER 0
  #undef CYTHON_USE_PYLONG_INTERNALS
  #define CYTHON_USE_PYLONG_INTERNALS 0
  #undef CYTHON_AVOID_BORROWED_REFS
  #define CYTHON_AVOID_BORROWED_REFS 1
  #undef CYTHON_ASSUME_SAFE_MACROS
  #define CYTHON_ASSUME_SAFE_MACROS 0
  #undef CYTHON_UNPACK_METHODS
  #define CYTHON_UNPACK_METHODS 0
  #undef CYTHON_FAST_THREAD_STATE
  #define CYTHON_FAST_THREAD_STATE 0
  #undef CYTHON_FAST_PYCALL
  #define CYTHON_FAST_PYCALL 0
  #undef CYTHON_PEP489_MULTI_PHASE_INIT
  #define CYTHON_PEP489_MULTI_PHASE_INIT 0
  #undef CYTHON_USE_TP_FINALIZE
  #define CYTHON_USE_TP_FINALIZE 0
  #undef CYTHON_USE_DICT_VERSIONS
  #define CYTHON_USE_DICT_VERSIONS 0
  #undef CYTHON_USE_EXC_INFO_STACK
  #define CYTHON_USE_EXC_INFO_STACK 0
#elif defined(PYSTON_VERSION)
  #define CYTHON_COMPILING_IN_PYPY 0
  #define CYTHON_COMPILING_IN_PYSTON 1
  #define CYTHON_COMPILING_IN_CPYTHON 0
  #ifndef CYTHON_USE_TYPE_SLOTS
    #define CYTHON_USE_TYPE_SLOTS 1
  #endif
  #undef CYTHON_USE_PYTYPE_LOOKUP
  #define CYTHON_USE_PYTYPE_LOOKUP 0
  #undef CYTHON_USE_ASYNC_SLOTS
  #define CYTHON_USE_ASYNC_SLOTS 0
  #undef CYTHON_USE_PYLIST_INTERNALS
  #define CYTHON_USE_PYLIST_INTERNALS 0
  #ifndef CYTHON_USE_UNICODE_INTERNALS
    #define CYTHON_USE_UNICODE_INTERNALS 1
  #endif
  #undef CYTHON_USE_UNICODE_WRITER
  #define CYTHON_USE_UNICODE_WRITER 0
  #undef CYTHON_USE_PYLONG_INTERNALS
  #define CYTHON_USE_PYLONG_INTERNALS 0
  #ifndef CYTHON_AVOID_BORROWED_REFS
    #define CYTHON_AVOID_BORROWED_REFS 0
  #endif
  #ifndef CYTHON_ASSUME_SAFE_MACROS
    #define CYTHON_ASSUME_SAFE_MACROS 1
  #endif
  #ifndef CYTHON_UNPACK_METHODS
    #define CYTHON_UNPACK_METHODS 1
  #endif
  #undef CYTHON_FAST_THREAD_STATE
  #define CYTHON_FAST_THREAD_STATE 0
  #undef CYTHON_FAST_PYCALL
  #define CYTHON_FAST_PYCALL 0
  #undef CYTHON_PEP489_MULTI_PHASE_INIT
  #define CYTHON_PEP489_MULTI_PHASE_INIT 0
  #undef CYTHON_USE_TP_FINALIZE
  #define CYTHON_USE_TP_FINALIZE 0
  #undef CYTHON_USE_DICT_VERSIONS
  #define CYTHON_USE_DICT_VERSIONS 0
  #undef CYTHON_USE_EXC_INFO_STACK
  #define CYTHON_USE_EXC_INFO_STACK 0
#else
  #define CYTHON_COMPILING_IN_PYPY 0
  #define CYTHON_COMPILING_IN_PYSTON 0
  #define CYTHON_COMPILING_IN_CPYTHON 1
  #ifndef CYTHON_USE_TYPE_SLOTS
    #define CYTHON_USE_TYPE_SLOTS 1
  #endif
  #if PY_VERSION_HEX < 0x02070000
    #undef CYTHON_USE_PYTYPE_LOOKUP
    #define CYTHON_USE_PYTYPE_LOOKUP 0
  #elif !defined(CYTHON_USE_PYTYPE_LOOKUP)
    #define CYTHON_USE_PYTYPE_LOOKUP 1
  #endif
  #if PY_MAJOR_VERSION < 3
    #undef CYTHON_USE_ASYNC_SLOTS
    #define CYTHON_USE_ASYNC_SLOTS 0
  #elif !defined(CYTHON_USE_ASYNC_SLOTS)
    #define CYTHON_USE_ASYNC_SLOTS 1
  #endif
  #if PY_VERSION_HEX < 0x02070000
    #undef CYTHON_USE_PYLONG_INTERNALS
    #define CYTHON_USE_PYLONG_INTERNALS 0
  #elif !defined(CYTHON_USE_PYLONG_INTERNALS)
    #define CYTHON_USE_PYLONG_INTERNALS 1
  #endif
  #ifndef CYTHON_USE_PYLIST_INTERNALS
    #define CYTHON_USE_PYLIST_INTERNALS 1
  #endif
  #ifndef CYTHON_USE_UNICODE_INTERNALS
    #define CYTHON_USE_UNICODE_INTERNALS 1
  #endif
  #if PY_VERSION_HEX < 0x030300F0
    #undef CYTHON_USE_UNICODE_WRITER
    #define CYTHON_USE_UNICODE_WRITER 0
  #elif !defined(CYTHON_USE_UNICODE_WRITER)
    #define CYTHON_USE_UNICODE_WRITER 1
  #endif
  #ifndef CYTHON_AVOID_BORROWED_REFS
    #define CYTHON_AVOID_BORROWED_REFS 0
  #endif
  #ifndef CYTHON_ASSUME_SAFE_MACROS
    #define CYTHON_ASSUME_SAFE_MACROS 1
  #endif
  #ifndef CYTHON_UNPACK_METHODS
    #define CYTHON_UNPACK_METHODS 1
  #endif
  #ifndef CYTHON_FAST_THREAD_STATE
    #define CYTHON_FAST_THREAD_STATE 1
  #endif
  #ifndef CYTHON_FAST_PYCALL
    #define CYTHON_FAST_PYCALL 1
  #endif
  #ifndef CYTHON_PEP489_MULTI_PHASE_INIT
    #define CYTHON_PEP489_MULTI_PHASE_INIT (PY_VERSION_HEX >= 0x03050000)
  #endif
  #ifndef CYTHON_USE_TP_FINALIZE
    #define CYTHON_USE_TP_FINALIZE (PY_VERSION_HEX >= 0x030400a1)
  #endif
  #ifndef CYTHON_USE_DICT_VERSIONS
    #define CYTHON_USE_DICT_VERSIONS (PY_VERSION_HEX >= 0x030600B1)
  #endif
  #ifndef CYTHON_USE_EXC_INFO_STACK
    #define CYTHON_USE_EXC_INFO_STACK (PY_VERSION_HEX >= 0x030700A3)
  #endif
#endif
#if !defined(CYTHON_FAST_PYCCALL)
#define CYTHON_FAST_PYCCALL  (CYTHON_FAST_PYCALL && PY_VERSION_HEX >= 0x030600B1)
#endif
#if CYTHON_USE_PYLONG_INTERNALS
  #include "longintrepr.h"
  #undef SHIFT
  #undef BASE
  #undef MASK
  #ifdef SIZEOF_VOID_P
    enum { __pyx_check_sizeof_voidp = 1 / (int)(SIZEOF_VOID_P == sizeof(void*)) };
  #endif
#endif
#ifndef __has_attribute
  #define __has_attribute(x) 0
#endif
#ifndef __has_cpp_attribute
  #define __has_cpp_attribute(x) 0
#endif
#ifndef CYTHON_RESTRICT
  #if defined(__GNUC__)
    #define CYTHON_RESTRICT __restrict__
  #elif defined(_MSC_VER) && _MSC_VER >= 1400
    #define CYTHON_RESTRICT __restrict
  #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
    #define CYTHON_RESTRICT restrict
  #else
    #define CYTHON_RESTRICT
  #endif
#endif
#ifndef CYTHON_UNUSED
# if defined(__GNUC__)
#   if !(defined(__cplusplus)) || (__GNUC__ > 3 || (__GNUC__ == 3 && __GNUC_MINOR__ >= 4))
#     define CYTHON_UNUSED __attribute__ ((__unused__))
#   else
#     define CYTHON_UNUSED
#   endif
# elif defined(__ICC) || (defined(__INTEL_COMPILER) && !defined(_MSC_VER))
#   define CYTHON_UNUSED __attribute__ ((__unused__))
# else
#   define CYTHON_UNUSED
# endif
#endif
#ifndef CYTHON_MAYBE_UNUSED_VAR
#  if defined(__cplusplus)
     template<class T> void CYTHON_MAYBE_UNUSED_VAR( const T& ) { }
#  else
#    define CYTHON_MAYBE_UNUSED_VAR(x) (void)(x)
#  endif
#endif
#ifndef CYTHON_NCP_UNUSED
# if CYTHON_COMPILING_IN_CPYTHON
#  define CYTHON_NCP_UNUSED
# else
#  define CYTHON_NCP_UNUSED CYTHON_UNUSED
# endif
#endif
#define __Pyx_void_to_None(void_result) ((void)(void_result), Py_INCREF(Py_None), Py_None)
#ifdef _MSC_VER
    #ifndef _MSC_STDINT_H_
        #if _MSC_VER < 1300
           typedef unsigned char     uint8_t;
           typedef unsigned int      uint32_t;
        #else
           typedef unsigned __int8   uint8_t;
           typedef unsigned __int32  uint32_t;
        #endif
    #endif
#else
   #include <stdint.h>
#endif
#ifndef CYTHON_FALLTHROUGH
  #if defined(__cplusplus) && __cplusplus >= 201103L
    #if __has_cpp_attribute(fallthrough)
      #define CYTHON_FALLTHROUGH [[fallthrough]]
    #elif __has_cpp_attribute(clang::fallthrough)
      #define CYTHON_FALLTHROUGH [[clang::fallthrough]]
    #elif __has_cpp_attribute(gnu::fallthrough)
      #define CYTHON_FALLTHROUGH [[gnu::fallthrough]]
    #endif
  #endif
  #ifndef CYTHON_FALLTHROUGH
    #if __has_attribute(fallthrough)
      #define CYTHON_FALLTHROUGH __attribute__((fallthrough))
    #else
      #define CYTHON_FALLTHROUGH
    #endif
  #endif
  #if defined(__clang__ ) && defined(__apple_build_version__)
    #if __apple_build_version__ < 7000000
      #undef  CYTHON_FALLTHROUGH
      #define CYTHON_FALLTHROUGH
    #endif
  #endif
#endif

#ifndef CYTHON_INLINE
  #if defined(__clang__)
    #define CYTHON_INLINE __inline__ __attribute__ ((__unused__))
  #elif defined(__GNUC__)
    #define CYTHON_INLINE __inline__
  #elif defined(_MSC_VER)
    #define CYTHON_INLINE __inline
  #elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
    #define CYTHON_INLINE inline
  #else
    #define CYTHON_INLINE
  #endif
#endif

#if CYTHON_COMPILING_IN_PYPY && PY_VERSION_HEX < 0x02070600 && !defined(Py_OptimizeFlag)
  #define Py_OptimizeFlag 0
#endif
#define __PYX_BUILD_PY_SSIZE_T "n"
#define CYTHON_FORMAT_SSIZE_T "z"
#if PY_MAJOR_VERSION < 3
  #define __Pyx_BUILTIN_MODULE_NAME "__builtin__"
  #define __Pyx_PyCode_New(a, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
          PyCode_New(a+k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
  #define __Pyx_DefaultClassType PyClass_Type
#else
  #define __Pyx_BUILTIN_MODULE_NAME "builtins"
#if PY_VERSION_HEX >= 0x030800A4 && PY_VERSION_HEX < 0x030800B2
  #define __Pyx_PyCode_New(a, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
          PyCode_New(a, 0, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
#else
  #define __Pyx_PyCode_New(a, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)\
          PyCode_New(a, k, l, s, f, code, c, n, v, fv, cell, fn, name, fline, lnos)
#endif
  #define __Pyx_DefaultClassType PyType_Type
#endif
#ifndef Py_TPFLAGS_CHECKTYPES
  #define Py_TPFLAGS_CHECKTYPES 0
#endif
#ifndef Py_TPFLAGS_HAVE_INDEX
  #define Py_TPFLAGS_HAVE_INDEX 0
#endif
#ifndef Py_TPFLAGS_HAVE_NEWBUFFER
  #define Py_TPFLAGS_HAVE_NEWBUFFER 0
#endif
#ifndef Py_TPFLAGS_HAVE_FINALIZE
  #define Py_TPFLAGS_HAVE_FINALIZE 0
#endif
#ifndef METH_STACKLESS
  #define METH_STACKLESS 0
#endif
#if PY_VERSION_HEX <= 0x030700A3 || !defined(METH_FASTCALL)
  #ifndef METH_FASTCALL
     #define METH_FASTCALL 0x80
  #endif
  typedef PyObject *(*__Pyx_PyCFunctionFast) (PyObject *self, PyObject *const *args, Py_ssize_t nargs);
  typedef PyObject *(*__Pyx_PyCFunctionFastWithKeywords) (PyObject *self, PyObject *const *args,
                                                          Py_ssize_t nargs, PyObject *kwnames);
#else
  #define __Pyx_PyCFunctionFast _PyCFunctionFast
  #define __Pyx_PyCFunctionFastWithKeywords _PyCFunctionFastWithKeywords
#endif
#if CYTHON_FAST_PYCCALL
#define __Pyx_PyFastCFunction_Check(func)\
    ((PyCFunction_Check(func) && (METH_FASTCALL == (PyCFunction_GET_FLAGS(func) & ~(METH_CLASS | METH_STATIC | METH_COEXIST | METH_KEYWORDS | METH_STACKLESS)))))
#else
#define __Pyx_PyFastCFunction_Check(func) 0
#endif
#if CYTHON_COMPILING_IN_PYPY && !defined(PyObject_Malloc)
  #define PyObject_Malloc(s)   PyMem_Malloc(s)
  #define PyObject_Free(p)     PyMem_Free(p)
  #define PyObject_Realloc(p)  PyMem_Realloc(p)
#endif
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x030400A1
  #define PyMem_RawMalloc(n)           PyMem_Malloc(n)
  #define PyMem_RawRealloc(p, n)       PyMem_Realloc(p, n)
  #define PyMem_RawFree(p)             PyMem_Free(p)
#endif
#if CYTHON_COMPILING_IN_PYSTON
  #define __Pyx_PyCode_HasFreeVars(co)  PyCode_HasFreeVars(co)
  #define __Pyx_PyFrame_SetLineNumber(frame, lineno) PyFrame_SetLineNumber(frame, lineno)
#else
  #define __Pyx_PyCode_HasFreeVars(co)  (PyCode_GetNumFree(co) > 0)
  #define __Pyx_PyFrame_SetLineNumber(frame, lineno)  (frame)->f_lineno = (lineno)
#endif
#if !CYTHON_FAST_THREAD_STATE || PY_VERSION_HEX < 0x02070000
  #define __Pyx_PyThreadState_Current PyThreadState_GET()
#elif PY_VERSION_HEX >= 0x03060000
  #define __Pyx_PyThreadState_Current _PyThreadState_UncheckedGet()
#elif PY_VERSION_HEX >= 0x03000000
  #define __Pyx_PyThreadState_Current PyThreadState_GET()
#else
  #define __Pyx_PyThreadState_Current _PyThreadState_Current
#endif
#if PY_VERSION_HEX < 0x030700A2 && !defined(PyThread_tss_create) && !defined(Py_tss_NEEDS_INIT)
#include "pythread.h"
#define Py_tss_NEEDS_INIT 0
typedef int Py_tss_t;
static CYTHON_INLINE int PyThread_tss_create(Py_tss_t *key) {
  *key = PyThread_create_key();
  return 0;
}
static CYTHON_INLINE Py_tss_t * PyThread_tss_alloc(void) {
  Py_tss_t *key = (Py_tss_t *)PyObject_Malloc(sizeof(Py_tss_t));
  *key = Py_tss_NEEDS_INIT;
  return key;
}
static CYTHON_INLINE void PyThread_tss_free(Py_tss_t *key) {
  PyObject_Free(key);
}
static CYTHON_INLINE int PyThread_tss_is_created(Py_tss_t *key) {
  return *key != Py_tss_NEEDS_INIT;
}
static CYTHON_INLINE void PyThread_tss_delete(Py_tss_t *key) {
  PyThread_delete_key(*key);
  *key = Py_tss_NEEDS_INIT;
}
static CYTHON_INLINE int PyThread_tss_set(Py_tss_t *key, void *value) {
  return PyThread_set_key_value(*key, value);
}
static CYTHON_INLINE void * PyThread_tss_get(Py_tss_t *key) {
  return PyThread_get_key_value(*key);
}
#endif
#if CYTHON_COMPILING_IN_CPYTHON || defined(_PyDict_NewPresized)
#define __Pyx_PyDict_NewPresized(n)  ((n <= 8) ? PyDict_New() : _PyDict_NewPresized(n))
#else
#define __Pyx_PyDict_NewPresized(n)  PyDict_New()
#endif
#if PY_MAJOR_VERSION >= 3 || CYTHON_FUTURE_DIVISION
  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_TrueDivide(x,y)
  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceTrueDivide(x,y)
#else
  #define __Pyx_PyNumber_Divide(x,y)         PyNumber_Divide(x,y)
  #define __Pyx_PyNumber_InPlaceDivide(x,y)  PyNumber_InPlaceDivide(x,y)
#endif
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030500A1 && CYTHON_USE_UNICODE_INTERNALS
#define __Pyx_PyDict_GetItemStr(dict, name)  _PyDict_GetItem_KnownHash(dict, name, ((PyASCIIObject *) name)->hash)
#else
#define __Pyx_PyDict_GetItemStr(dict, name)  PyDict_GetItem(dict, name)
#endif
#if PY_VERSION_HEX > 0x03030000 && defined(PyUnicode_KIND)
  #define CYTHON_PEP393_ENABLED 1
  #define __Pyx_PyUnicode_READY(op)       (likely(PyUnicode_IS_READY(op)) ?\
                                              0 : _PyUnicode_Ready((PyObject *)(op)))
  #define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GET_LENGTH(u)
  #define __Pyx_PyUnicode_READ_CHAR(u, i) PyUnicode_READ_CHAR(u, i)
  #define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   PyUnicode_MAX_CHAR_VALUE(u)
  #define __Pyx_PyUnicode_KIND(u)         PyUnicode_KIND(u)
  #define __Pyx_PyUnicode_DATA(u)         PyUnicode_DATA(u)
  #define __Pyx_PyUnicode_READ(k, d, i)   PyUnicode_READ(k, d, i)
  #define __Pyx_PyUnicode_WRITE(k, d, i, ch)  PyUnicode_WRITE(k, d, i, ch)
  #define __Pyx_PyUnicode_IS_TRUE(u)      (0 != (likely(PyUnicode_IS_READY(u)) ? PyUnicode_GET_LENGTH(u) : PyUnicode_GET_SIZE(u)))
#else
  #define CYTHON_PEP393_ENABLED 0
  #define PyUnicode_1BYTE_KIND  1
  #define PyUnicode_2BYTE_KIND  2
  #define PyUnicode_4BYTE_KIND  4
  #define __Pyx_PyUnicode_READY(op)       (0)
  #define __Pyx_PyUnicode_GET_LENGTH(u)   PyUnicode_GET_SIZE(u)
  #define __Pyx_PyUnicode_READ_CHAR(u, i) ((Py_UCS4)(PyUnicode_AS_UNICODE(u)[i]))
  #define __Pyx_PyUnicode_MAX_CHAR_VALUE(u)   ((sizeof(Py_UNICODE) == 2) ? 65535 : 1114111)
  #define __Pyx_PyUnicode_KIND(u)         (sizeof(Py_UNICODE))
  #define __Pyx_PyUnicode_DATA(u)         ((void*)PyUnicode_AS_UNICODE(u))
  #define __Pyx_PyUnicode_READ(k, d, i)   ((void)(k), (Py_UCS4)(((Py_UNICODE*)d)[i]))
  #define __Pyx_PyUnicode_WRITE(k, d, i, ch)  (((void)(k)), ((Py_UNICODE*)d)[i] = ch)
  #define __Pyx_PyUnicode_IS_TRUE(u)      (0 != PyUnicode_GET_SIZE(u))
#endif
#if CYTHON_COMPILING_IN_PYPY
  #define __Pyx_PyUnicode_Concat(a, b)      PyNumber_Add(a, b)
  #define __Pyx_PyUnicode_ConcatSafe(a, b)  PyNumber_Add(a, b)
#else
  #define __Pyx_PyUnicode_Concat(a, b)      PyUnicode_Concat(a, b)
  #define __Pyx_PyUnicode_ConcatSafe(a, b)  ((unlikely((a) == Py_None) || unlikely((b) == Py_None)) ?\
      PyNumber_Add(a, b) : __Pyx_PyUnicode_Concat(a, b))
#endif
#if CYTHON_COMPILING_IN_PYPY && !defined(PyUnicode_Contains)
  #define PyUnicode_Contains(u, s)  PySequence_Contains(u, s)
#endif
#if CYTHON_COMPILING_IN_PYPY && !defined(PyByteArray_Check)
  #define PyByteArray_Check(obj)  PyObject_TypeCheck(obj, &PyByteArray_Type)
#endif
#if CYTHON_COMPILING_IN_PYPY && !defined(PyObject_Format)
  #define PyObject_Format(obj, fmt)  PyObject_CallMethod(obj, "__format__", "O", fmt)
#endif
#define __Pyx_PyString_FormatSafe(a, b)   ((unlikely((a) == Py_None || (PyString_Check(b) && !PyString_CheckExact(b)))) ? PyNumber_Remainder(a, b) : __Pyx_PyString_Format(a, b))
#define __Pyx_PyUnicode_FormatSafe(a, b)  ((unlikely((a) == Py_None || (PyUnicode_Check(b) && !PyUnicode_CheckExact(b)))) ? PyNumber_Remainder(a, b) : PyUnicode_Format(a, b))
#if PY_MAJOR_VERSION >= 3
  #define __Pyx_PyString_Format(a, b)  PyUnicode_Format(a, b)
#else
  #define __Pyx_PyString_Format(a, b)  PyString_Format(a, b)
#endif
#if PY_MAJOR_VERSION < 3 && !defined(PyObject_ASCII)
  #define PyObject_ASCII(o)            PyObject_Repr(o)
#endif
#if PY_MAJOR_VERSION >= 3
  #define PyBaseString_Type            PyUnicode_Type
  #define PyStringObject               PyUnicodeObject
  #define PyString_Type                PyUnicode_Type
  #define PyString_Check               PyUnicode_Check
  #define PyString_CheckExact          PyUnicode_CheckExact
  #define PyObject_Unicode             PyObject_Str
#endif
#if PY_MAJOR_VERSION >= 3
  #define __Pyx_PyBaseString_Check(obj) PyUnicode_Check(obj)
  #define __Pyx_PyBaseString_CheckExact(obj) PyUnicode_CheckExact(obj)
#else
  #define __Pyx_PyBaseString_Check(obj) (PyString_Check(obj) || PyUnicode_Check(obj))
  #define __Pyx_PyBaseString_CheckExact(obj) (PyString_CheckExact(obj) || PyUnicode_CheckExact(obj))
#endif
#ifndef PySet_CheckExact
  #define PySet_CheckExact(obj)        (Py_TYPE(obj) == &PySet_Type)
#endif
#if CYTHON_ASSUME_SAFE_MACROS
  #define __Pyx_PySequence_SIZE(seq)  Py_SIZE(seq)
#else
  #define __Pyx_PySequence_SIZE(seq)  PySequence_Size(seq)
#endif
#if PY_MAJOR_VERSION >= 3
  #define PyIntObject                  PyLongObject
  #define PyInt_Type                   PyLong_Type
  #define PyInt_Check(op)              PyLong_Check(op)
  #define PyInt_CheckExact(op)         PyLong_CheckExact(op)
  #define PyInt_FromString             PyLong_FromString
  #define PyInt_FromUnicode            PyLong_FromUnicode
  #define PyInt_FromLong               PyLong_FromLong
  #define PyInt_FromSize_t             PyLong_FromSize_t
  #define PyInt_FromSsize_t            PyLong_FromSsize_t
  #define PyInt_AsLong                 PyLong_AsLong
  #define PyInt_AS_LONG                PyLong_AS_LONG
  #define PyInt_AsSsize_t              PyLong_AsSsize_t
  #define PyInt_AsUnsignedLongMask     PyLong_AsUnsignedLongMask
  #define PyInt_AsUnsignedLongLongMask PyLong_AsUnsignedLongLongMask
  #define PyNumber_Int                 PyNumber_Long
#endif
#if PY_MAJOR_VERSION >= 3
  #define PyBoolObject                 PyLongObject
#endif
#if PY_MAJOR_VERSION >= 3 && CYTHON_COMPILING_IN_PYPY
  #ifndef PyUnicode_InternFromString
    #define PyUnicode_InternFromString(s) PyUnicode_FromString(s)
  #endif
#endif
#if PY_VERSION_HEX < 0x030200A4
  typedef long Py_hash_t;
  #define __Pyx_PyInt_FromHash_t PyInt_FromLong
  #define __Pyx_PyInt_AsHash_t   PyInt_AsLong
#else
  #define __Pyx_PyInt_FromHash_t PyInt_FromSsize_t
  #define __Pyx_PyInt_AsHash_t   PyInt_AsSsize_t
#endif
#if PY_MAJOR_VERSION >= 3
  #define __Pyx_PyMethod_New(func, self, klass) ((self) ? PyMethod_New(func, self) : (Py_INCREF(func), func))
#else
  #define __Pyx_PyMethod_New(func, self, klass) PyMethod_New(func, self, klass)
#endif
#if CYTHON_USE_ASYNC_SLOTS
  #if PY_VERSION_HEX >= 0x030500B1
    #define __Pyx_PyAsyncMethodsStruct PyAsyncMethods
    #define __Pyx_PyType_AsAsync(obj) (Py_TYPE(obj)->tp_as_async)
  #else
    #define __Pyx_PyType_AsAsync(obj) ((__Pyx_PyAsyncMethodsStruct*) (Py_TYPE(obj)->tp_reserved))
  #endif
#else
  #define __Pyx_PyType_AsAsync(obj) NULL
#endif
#ifndef __Pyx_PyAsyncMethodsStruct
    typedef struct {
        unaryfunc am_await;
        unaryfunc am_aiter;
        unaryfunc am_anext;
    } __Pyx_PyAsyncMethodsStruct;
#endif

#if defined(WIN32) || defined(MS_WINDOWS)
  #define _USE_MATH_DEFINES
#endif
#include <math.h>
#ifdef NAN
#define __PYX_NAN() ((float) NAN)
#else
static CYTHON_INLINE float __PYX_NAN() {
  float value;
  memset(&value, 0xFF, sizeof(value));
  return value;
}
#endif
#if defined(__CYGWIN__) && defined(_LDBL_EQ_DBL)
#define __Pyx_truncl trunc
#else
#define __Pyx_truncl truncl
#endif


#define __PYX_ERR(f_index, lineno, Ln_error) \
{ \
  __pyx_filename = __pyx_f[f_index]; __pyx_lineno = lineno; __pyx_clineno = __LINE__; goto Ln_error; \
}

#ifndef __PYX_EXTERN_C
  #ifdef __cplusplus
    #define __PYX_EXTERN_C extern "C"
  #else
    #define __PYX_EXTERN_C extern
  #endif
#endif

#define __PYX_HAVE__MACS2__IO__CallPeakUnit
#define __PYX_HAVE_API__MACS2__IO__CallPeakUnit
/* Early includes */
#include <string.h>
#include <stdio.h>
#include "numpy/arrayobject.h"
#include "numpy/ufuncobject.h"
#include "pythread.h"
#include <math.h>
#ifdef _OPENMP
#include <omp.h>
#endif /* _OPENMP */

#if defined(PYREX_WITHOUT_ASSERTIONS) && !defined(CYTHON_WITHOUT_ASSERTIONS)
#define CYTHON_WITHOUT_ASSERTIONS
#endif

typedef struct {PyObject **p; const char *s; const Py_ssize_t n; const char* encoding;
                const char is_unicode; const char is_str; const char intern; } __Pyx_StringTabEntry;

#define __PYX_DEFAULT_STRING_ENCODING_IS_ASCII 0
#define __PYX_DEFAULT_STRING_ENCODING_IS_UTF8 0
#define __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT (PY_MAJOR_VERSION >= 3 && __PYX_DEFAULT_STRING_ENCODING_IS_UTF8)
#define __PYX_DEFAULT_STRING_ENCODING ""
#define __Pyx_PyObject_FromString __Pyx_PyBytes_FromString
#define __Pyx_PyObject_FromStringAndSize __Pyx_PyBytes_FromStringAndSize
#define __Pyx_uchar_cast(c) ((unsigned char)c)
#define __Pyx_long_cast(x) ((long)x)
#define __Pyx_fits_Py_ssize_t(v, type, is_signed)  (\
    (sizeof(type) < sizeof(Py_ssize_t))  ||\
    (sizeof(type) > sizeof(Py_ssize_t) &&\
          likely(v < (type)PY_SSIZE_T_MAX ||\
                 v == (type)PY_SSIZE_T_MAX)  &&\
          (!is_signed || likely(v > (type)PY_SSIZE_T_MIN ||\
                                v == (type)PY_SSIZE_T_MIN)))  ||\
    (sizeof(type) == sizeof(Py_ssize_t) &&\
          (is_signed || likely(v < (type)PY_SSIZE_T_MAX ||\
                               v == (type)PY_SSIZE_T_MAX)))  )
static CYTHON_INLINE int __Pyx_is_valid_index(Py_ssize_t i, Py_ssize_t limit) {
    return (size_t) i < (size_t) limit;
}
#if defined (__cplusplus) && __cplusplus >= 201103L
    #include <cstdlib>
    #define __Pyx_sst_abs(value) std::abs(value)
#elif SIZEOF_INT >= SIZEOF_SIZE_T
    #define __Pyx_sst_abs(value) abs(value)
#elif SIZEOF_LONG >= SIZEOF_SIZE_T
    #define __Pyx_sst_abs(value) labs(value)
#elif defined (_MSC_VER)
    #define __Pyx_sst_abs(value) ((Py_ssize_t)_abs64(value))
#elif defined (__STDC_VERSION__) && __STDC_VERSION__ >= 199901L
    #define __Pyx_sst_abs(value) llabs(value)
#elif defined (__GNUC__)
    #define __Pyx_sst_abs(value) __builtin_llabs(value)
#else
    #define __Pyx_sst_abs(value) ((value<0) ? -value : value)
#endif
static CYTHON_INLINE const char* __Pyx_PyObject_AsString(PyObject*);
static CYTHON_INLINE const char* __Pyx_PyObject_AsStringAndSize(PyObject*, Py_ssize_t* length);
#define __Pyx_PyByteArray_FromString(s) PyByteArray_FromStringAndSize((const char*)s, strlen((const char*)s))
#define __Pyx_PyByteArray_FromStringAndSize(s, l) PyByteArray_FromStringAndSize((const char*)s, l)
#define __Pyx_PyBytes_FromString        PyBytes_FromString
#define __Pyx_PyBytes_FromStringAndSize PyBytes_FromStringAndSize
static CYTHON_INLINE PyObject* __Pyx_PyUnicode_FromString(const char*);
#if PY_MAJOR_VERSION < 3
    #define __Pyx_PyStr_FromString        __Pyx_PyBytes_FromString
    #define __Pyx_PyStr_FromStringAndSize __Pyx_PyBytes_FromStringAndSize
#else
    #define __Pyx_PyStr_FromString        __Pyx_PyUnicode_FromString
    #define __Pyx_PyStr_FromStringAndSize __Pyx_PyUnicode_FromStringAndSize
#endif
#define __Pyx_PyBytes_AsWritableString(s)     ((char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsWritableSString(s)    ((signed char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsWritableUString(s)    ((unsigned char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsString(s)     ((const char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsSString(s)    ((const signed char*) PyBytes_AS_STRING(s))
#define __Pyx_PyBytes_AsUString(s)    ((const unsigned char*) PyBytes_AS_STRING(s))
#define __Pyx_PyObject_AsWritableString(s)    ((char*) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsWritableSString(s)    ((signed char*) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsWritableUString(s)    ((unsigned char*) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsSString(s)    ((const signed char*) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_AsUString(s)    ((const unsigned char*) __Pyx_PyObject_AsString(s))
#define __Pyx_PyObject_FromCString(s)  __Pyx_PyObject_FromString((const char*)s)
#define __Pyx_PyBytes_FromCString(s)   __Pyx_PyBytes_FromString((const char*)s)
#define __Pyx_PyByteArray_FromCString(s)   __Pyx_PyByteArray_FromString((const char*)s)
#define __Pyx_PyStr_FromCString(s)     __Pyx_PyStr_FromString((const char*)s)
#define __Pyx_PyUnicode_FromCString(s) __Pyx_PyUnicode_FromString((const char*)s)
static CYTHON_INLINE size_t __Pyx_Py_UNICODE_strlen(const Py_UNICODE *u) {
    const Py_UNICODE *u_end = u;
    while (*u_end++) ;
    return (size_t)(u_end - u - 1);
}
#define __Pyx_PyUnicode_FromUnicode(u)       PyUnicode_FromUnicode(u, __Pyx_Py_UNICODE_strlen(u))
#define __Pyx_PyUnicode_FromUnicodeAndLength PyUnicode_FromUnicode
#define __Pyx_PyUnicode_AsUnicode            PyUnicode_AsUnicode
#define __Pyx_NewRef(obj) (Py_INCREF(obj), obj)
#define __Pyx_Owned_Py_None(b) __Pyx_NewRef(Py_None)
static CYTHON_INLINE PyObject * __Pyx_PyBool_FromLong(long b);
static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject*);
static CYTHON_INLINE int __Pyx_PyObject_IsTrueAndDecref(PyObject*);
static CYTHON_INLINE PyObject* __Pyx_PyNumber_IntOrLong(PyObject* x);
#define __Pyx_PySequence_Tuple(obj)\
    (likely(PyTuple_CheckExact(obj)) ? __Pyx_NewRef(obj) : PySequence_Tuple(obj))
static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject*);
static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t);
#if CYTHON_ASSUME_SAFE_MACROS
#define __pyx_PyFloat_AsDouble(x) (PyFloat_CheckExact(x) ? PyFloat_AS_DOUBLE(x) : PyFloat_AsDouble(x))
#else
#define __pyx_PyFloat_AsDouble(x) PyFloat_AsDouble(x)
#endif
#define __pyx_PyFloat_AsFloat(x) ((float) __pyx_PyFloat_AsDouble(x))
#if PY_MAJOR_VERSION >= 3
#define __Pyx_PyNumber_Int(x) (PyLong_CheckExact(x) ? __Pyx_NewRef(x) : PyNumber_Long(x))
#else
#define __Pyx_PyNumber_Int(x) (PyInt_CheckExact(x) ? __Pyx_NewRef(x) : PyNumber_Int(x))
#endif
#define __Pyx_PyNumber_Float(x) (PyFloat_CheckExact(x) ? __Pyx_NewRef(x) : PyNumber_Float(x))
#if PY_MAJOR_VERSION < 3 && __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
static int __Pyx_sys_getdefaultencoding_not_ascii;
static int __Pyx_init_sys_getdefaultencoding_params(void) {
    PyObject* sys;
    PyObject* default_encoding = NULL;
    PyObject* ascii_chars_u = NULL;
    PyObject* ascii_chars_b = NULL;
    const char* default_encoding_c;
    sys = PyImport_ImportModule("sys");
    if (!sys) goto bad;
    default_encoding = PyObject_CallMethod(sys, (char*) "getdefaultencoding", NULL);
    Py_DECREF(sys);
    if (!default_encoding) goto bad;
    default_encoding_c = PyBytes_AsString(default_encoding);
    if (!default_encoding_c) goto bad;
    if (strcmp(default_encoding_c, "ascii") == 0) {
        __Pyx_sys_getdefaultencoding_not_ascii = 0;
    } else {
        char ascii_chars[128];
        int c;
        for (c = 0; c < 128; c++) {
            ascii_chars[c] = c;
        }
        __Pyx_sys_getdefaultencoding_not_ascii = 1;
        ascii_chars_u = PyUnicode_DecodeASCII(ascii_chars, 128, NULL);
        if (!ascii_chars_u) goto bad;
        ascii_chars_b = PyUnicode_AsEncodedString(ascii_chars_u, default_encoding_c, NULL);
        if (!ascii_chars_b || !PyBytes_Check(ascii_chars_b) || memcmp(ascii_chars, PyBytes_AS_STRING(ascii_chars_b), 128) != 0) {
            PyErr_Format(
                PyExc_ValueError,
                "This module compiled with c_string_encoding=ascii, but default encoding '%.200s' is not a superset of ascii.",
                default_encoding_c);
            goto bad;
        }
        Py_DECREF(ascii_chars_u);
        Py_DECREF(ascii_chars_b);
    }
    Py_DECREF(default_encoding);
    return 0;
bad:
    Py_XDECREF(default_encoding);
    Py_XDECREF(ascii_chars_u);
    Py_XDECREF(ascii_chars_b);
    return -1;
}
#endif
#if __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT && PY_MAJOR_VERSION >= 3
#define __Pyx_PyUnicode_FromStringAndSize(c_str, size) PyUnicode_DecodeUTF8(c_str, size, NULL)
#else
#define __Pyx_PyUnicode_FromStringAndSize(c_str, size) PyUnicode_Decode(c_str, size, __PYX_DEFAULT_STRING_ENCODING, NULL)
#if __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
static char* __PYX_DEFAULT_STRING_ENCODING;
static int __Pyx_init_sys_getdefaultencoding_params(void) {
    PyObject* sys;
    PyObject* default_encoding = NULL;
    char* default_encoding_c;
    sys = PyImport_ImportModule("sys");
    if (!sys) goto bad;
    default_encoding = PyObject_CallMethod(sys, (char*) (const char*) "getdefaultencoding", NULL);
    Py_DECREF(sys);
    if (!default_encoding) goto bad;
    default_encoding_c = PyBytes_AsString(default_encoding);
    if (!default_encoding_c) goto bad;
    __PYX_DEFAULT_STRING_ENCODING = (char*) malloc(strlen(default_encoding_c) + 1);
    if (!__PYX_DEFAULT_STRING_ENCODING) goto bad;
    strcpy(__PYX_DEFAULT_STRING_ENCODING, default_encoding_c);
    Py_DECREF(default_encoding);
    return 0;
bad:
    Py_XDECREF(default_encoding);
    return -1;
}
#endif
#endif


/* Test for GCC > 2.95 */
#if defined(__GNUC__)     && (__GNUC__ > 2 || (__GNUC__ == 2 && (__GNUC_MINOR__ > 95)))
  #define likely(x)   __builtin_expect(!!(x), 1)
  #define unlikely(x) __builtin_expect(!!(x), 0)
#else /* !__GNUC__ or GCC < 2.95 */
  #define likely(x)   (x)
  #define unlikely(x) (x)
#endif /* __GNUC__ */
static CYTHON_INLINE void __Pyx_pretend_to_initialize(void* ptr) { (void)ptr; }

static PyObject *__pyx_m = NULL;
static PyObject *__pyx_d;
static PyObject *__pyx_b;
static PyObject *__pyx_cython_runtime = NULL;
static PyObject *__pyx_empty_tuple;
static PyObject *__pyx_empty_bytes;
static PyObject *__pyx_empty_unicode;
static int __pyx_lineno;
static int __pyx_clineno = 0;
static const char * __pyx_cfilenm= __FILE__;
static const char *__pyx_filename;

/* Header.proto */
#if !defined(CYTHON_CCOMPLEX)
  #if defined(__cplusplus)
    #define CYTHON_CCOMPLEX 1
  #elif defined(_Complex_I)
    #define CYTHON_CCOMPLEX 1
  #else
    #define CYTHON_CCOMPLEX 0
  #endif
#endif
#if CYTHON_CCOMPLEX
  #ifdef __cplusplus
    #include <complex>
  #else
    #include <complex.h>
  #endif
#endif
#if CYTHON_CCOMPLEX && !defined(__cplusplus) && defined(__sun__) && defined(__GNUC__)
  #undef _Complex_I
  #define _Complex_I 1.0fj
#endif


static const char *__pyx_f[] = {
  "MACS2/IO/CallPeakUnit.pyx",
  "stringsource",
  "__init__.pxd",
  "type.pxd",
  "bool.pxd",
  "complex.pxd",
};
/* BufferFormatStructs.proto */
#define IS_UNSIGNED(type) (((type) -1) > 0)
struct __Pyx_StructField_;
#define __PYX_BUF_FLAGS_PACKED_STRUCT (1 << 0)
typedef struct {
  const char* name;
  struct __Pyx_StructField_* fields;
  size_t size;
  size_t arraysize[8];
  int ndim;
  char typegroup;
  char is_unsigned;
  int flags;
} __Pyx_TypeInfo;
typedef struct __Pyx_StructField_ {
  __Pyx_TypeInfo* type;
  const char* name;
  size_t offset;
} __Pyx_StructField;
typedef struct {
  __Pyx_StructField* field;
  size_t parent_offset;
} __Pyx_BufFmt_StackElem;
typedef struct {
  __Pyx_StructField root;
  __Pyx_BufFmt_StackElem* head;
  size_t fmt_offset;
  size_t new_count, enc_count;
  size_t struct_alignment;
  int is_complex;
  char enc_type;
  char new_packmode;
  char enc_packmode;
  char is_valid_array;
} __Pyx_BufFmt_Context;


/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":776
 * # in Cython to enable them only on the right systems.
 * 
 * ctypedef npy_int8       int8_t             # <<<<<<<<<<<<<<
 * ctypedef npy_int16      int16_t
 * ctypedef npy_int32      int32_t
 */
typedef npy_int8 __pyx_t_5numpy_int8_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":777
 * 
 * ctypedef npy_int8       int8_t
 * ctypedef npy_int16      int16_t             # <<<<<<<<<<<<<<
 * ctypedef npy_int32      int32_t
 * ctypedef npy_int64      int64_t
 */
typedef npy_int16 __pyx_t_5numpy_int16_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":778
 * ctypedef npy_int8       int8_t
 * ctypedef npy_int16      int16_t
 * ctypedef npy_int32      int32_t             # <<<<<<<<<<<<<<
 * ctypedef npy_int64      int64_t
 * #ctypedef npy_int96      int96_t
 */
typedef npy_int32 __pyx_t_5numpy_int32_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":779
 * ctypedef npy_int16      int16_t
 * ctypedef npy_int32      int32_t
 * ctypedef npy_int64      int64_t             # <<<<<<<<<<<<<<
 * #ctypedef npy_int96      int96_t
 * #ctypedef npy_int128     int128_t
 */
typedef npy_int64 __pyx_t_5numpy_int64_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":783
 * #ctypedef npy_int128     int128_t
 * 
 * ctypedef npy_uint8      uint8_t             # <<<<<<<<<<<<<<
 * ctypedef npy_uint16     uint16_t
 * ctypedef npy_uint32     uint32_t
 */
typedef npy_uint8 __pyx_t_5numpy_uint8_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":784
 * 
 * ctypedef npy_uint8      uint8_t
 * ctypedef npy_uint16     uint16_t             # <<<<<<<<<<<<<<
 * ctypedef npy_uint32     uint32_t
 * ctypedef npy_uint64     uint64_t
 */
typedef npy_uint16 __pyx_t_5numpy_uint16_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":785
 * ctypedef npy_uint8      uint8_t
 * ctypedef npy_uint16     uint16_t
 * ctypedef npy_uint32     uint32_t             # <<<<<<<<<<<<<<
 * ctypedef npy_uint64     uint64_t
 * #ctypedef npy_uint96     uint96_t
 */
typedef npy_uint32 __pyx_t_5numpy_uint32_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":786
 * ctypedef npy_uint16     uint16_t
 * ctypedef npy_uint32     uint32_t
 * ctypedef npy_uint64     uint64_t             # <<<<<<<<<<<<<<
 * #ctypedef npy_uint96     uint96_t
 * #ctypedef npy_uint128    uint128_t
 */
typedef npy_uint64 __pyx_t_5numpy_uint64_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":790
 * #ctypedef npy_uint128    uint128_t
 * 
 * ctypedef npy_float32    float32_t             # <<<<<<<<<<<<<<
 * ctypedef npy_float64    float64_t
 * #ctypedef npy_float80    float80_t
 */
typedef npy_float32 __pyx_t_5numpy_float32_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":791
 * 
 * ctypedef npy_float32    float32_t
 * ctypedef npy_float64    float64_t             # <<<<<<<<<<<<<<
 * #ctypedef npy_float80    float80_t
 * #ctypedef npy_float128   float128_t
 */
typedef npy_float64 __pyx_t_5numpy_float64_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":800
 * # The int types are mapped a bit surprising --
 * # numpy.int corresponds to 'l' and numpy.long to 'q'
 * ctypedef npy_long       int_t             # <<<<<<<<<<<<<<
 * ctypedef npy_longlong   long_t
 * ctypedef npy_longlong   longlong_t
 */
typedef npy_long __pyx_t_5numpy_int_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":801
 * # numpy.int corresponds to 'l' and numpy.long to 'q'
 * ctypedef npy_long       int_t
 * ctypedef npy_longlong   long_t             # <<<<<<<<<<<<<<
 * ctypedef npy_longlong   longlong_t
 * 
 */
typedef npy_longlong __pyx_t_5numpy_long_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":802
 * ctypedef npy_long       int_t
 * ctypedef npy_longlong   long_t
 * ctypedef npy_longlong   longlong_t             # <<<<<<<<<<<<<<
 * 
 * ctypedef npy_ulong      uint_t
 */
typedef npy_longlong __pyx_t_5numpy_longlong_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":804
 * ctypedef npy_longlong   longlong_t
 * 
 * ctypedef npy_ulong      uint_t             # <<<<<<<<<<<<<<
 * ctypedef npy_ulonglong  ulong_t
 * ctypedef npy_ulonglong  ulonglong_t
 */
typedef npy_ulong __pyx_t_5numpy_uint_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":805
 * 
 * ctypedef npy_ulong      uint_t
 * ctypedef npy_ulonglong  ulong_t             # <<<<<<<<<<<<<<
 * ctypedef npy_ulonglong  ulonglong_t
 * 
 */
typedef npy_ulonglong __pyx_t_5numpy_ulong_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":806
 * ctypedef npy_ulong      uint_t
 * ctypedef npy_ulonglong  ulong_t
 * ctypedef npy_ulonglong  ulonglong_t             # <<<<<<<<<<<<<<
 * 
 * ctypedef npy_intp       intp_t
 */
typedef npy_ulonglong __pyx_t_5numpy_ulonglong_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":808
 * ctypedef npy_ulonglong  ulonglong_t
 * 
 * ctypedef npy_intp       intp_t             # <<<<<<<<<<<<<<
 * ctypedef npy_uintp      uintp_t
 * 
 */
typedef npy_intp __pyx_t_5numpy_intp_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":809
 * 
 * ctypedef npy_intp       intp_t
 * ctypedef npy_uintp      uintp_t             # <<<<<<<<<<<<<<
 * 
 * ctypedef npy_double     float_t
 */
typedef npy_uintp __pyx_t_5numpy_uintp_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":811
 * ctypedef npy_uintp      uintp_t
 * 
 * ctypedef npy_double     float_t             # <<<<<<<<<<<<<<
 * ctypedef npy_double     double_t
 * ctypedef npy_longdouble longdouble_t
 */
typedef npy_double __pyx_t_5numpy_float_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":812
 * 
 * ctypedef npy_double     float_t
 * ctypedef npy_double     double_t             # <<<<<<<<<<<<<<
 * ctypedef npy_longdouble longdouble_t
 * 
 */
typedef npy_double __pyx_t_5numpy_double_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":813
 * ctypedef npy_double     float_t
 * ctypedef npy_double     double_t
 * ctypedef npy_longdouble longdouble_t             # <<<<<<<<<<<<<<
 * 
 * ctypedef npy_cfloat      cfloat_t
 */
typedef npy_longdouble __pyx_t_5numpy_longdouble_t;
/* Declarations.proto */
#if CYTHON_CCOMPLEX
  #ifdef __cplusplus
    typedef ::std::complex< float > __pyx_t_float_complex;
  #else
    typedef float _Complex __pyx_t_float_complex;
  #endif
#else
    typedef struct { float real, imag; } __pyx_t_float_complex;
#endif
static CYTHON_INLINE __pyx_t_float_complex __pyx_t_float_complex_from_parts(float, float);

/* Declarations.proto */
#if CYTHON_CCOMPLEX
  #ifdef __cplusplus
    typedef ::std::complex< double > __pyx_t_double_complex;
  #else
    typedef double _Complex __pyx_t_double_complex;
  #endif
#else
    typedef struct { double real, imag; } __pyx_t_double_complex;
#endif
static CYTHON_INLINE __pyx_t_double_complex __pyx_t_double_complex_from_parts(double, double);


/*--- Type declarations ---*/
struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":815
 * ctypedef npy_longdouble longdouble_t
 * 
 * ctypedef npy_cfloat      cfloat_t             # <<<<<<<<<<<<<<
 * ctypedef npy_cdouble     cdouble_t
 * ctypedef npy_clongdouble clongdouble_t
 */
typedef npy_cfloat __pyx_t_5numpy_cfloat_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":816
 * 
 * ctypedef npy_cfloat      cfloat_t
 * ctypedef npy_cdouble     cdouble_t             # <<<<<<<<<<<<<<
 * ctypedef npy_clongdouble clongdouble_t
 * 
 */
typedef npy_cdouble __pyx_t_5numpy_cdouble_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":817
 * ctypedef npy_cfloat      cfloat_t
 * ctypedef npy_cdouble     cdouble_t
 * ctypedef npy_clongdouble clongdouble_t             # <<<<<<<<<<<<<<
 * 
 * ctypedef npy_cdouble     complex_t
 */
typedef npy_clongdouble __pyx_t_5numpy_clongdouble_t;

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":819
 * ctypedef npy_clongdouble clongdouble_t
 * 
 * ctypedef npy_cdouble     complex_t             # <<<<<<<<<<<<<<
 * 
 * cdef inline object PyArray_MultiIterNew1(a):
 */
typedef npy_cdouble __pyx_t_5numpy_complex_t;
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes;
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks;
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks;
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks;
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks;
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region;
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution;

/* "MACS2/IO/CallPeakUnit.pyx":736
 * 
 * 
 *     cdef void __pre_computes ( self, int32_t max_gap = 50, int32_t min_length = 200 ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.pqtable and self.pvalue_length is built. All
 *         chromosomes will be iterated. So it will take some time.
 */
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes {
  int __pyx_n;
  __pyx_t_5numpy_int32_t max_gap;
  __pyx_t_5numpy_int32_t min_length;
};

/* "MACS2/IO/CallPeakUnit.pyx":896
 *         return
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,             # <<<<<<<<<<<<<<
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 */
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks {
  int __pyx_n;
  __pyx_t_5numpy_int32_t min_length;
  __pyx_t_5numpy_int32_t max_gap;
  PyBoolObject *call_summits;
  PyBoolObject *cutoff_analysis;
};

/* "MACS2/IO/CallPeakUnit.pyx":1100
 *         return
 * 
 *     cdef bool __close_peak_wo_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                           bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the peak region, output peak boundaries, peak summit
 */
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks {
  int __pyx_n;
  PyObject *score_cutoff_s;
};

/* "MACS2/IO/CallPeakUnit.pyx":1161
 *             return True
 * 
 *     cdef bool __close_peak_with_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                          bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[],
 *                                          float32_t min_valley = 0.9 ):
 */
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks {
  int __pyx_n;
  PyObject *score_cutoff_s;
  __pyx_t_5numpy_float32_t min_valley;
};

/* "MACS2/IO/CallPeakUnit.pyx":1461
 *         return True
 * 
 *     cpdef call_broadpeaks (self, list scoring_function_symbols, list lvl1_cutoff_s, list lvl2_cutoff_s, int32_t min_length=200, int32_t lvl1_max_gap=50, int32_t lvl2_max_gap=400, bool cutoff_analysis = False):             # <<<<<<<<<<<<<<
 *         """This function try to find enriched regions within which,
 *         scores are continuously higher than a given cutoff for level
 */
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks {
  int __pyx_n;
  __pyx_t_5numpy_int32_t min_length;
  __pyx_t_5numpy_int32_t lvl1_max_gap;
  __pyx_t_5numpy_int32_t lvl2_max_gap;
  PyBoolObject *cutoff_analysis;
};

/* "MACS2/IO/CallPeakUnit.pyx":1740
 *         return
 * 
 *     cdef bool __close_peak_for_broad_region (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                              bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the broad peak region, output peak boundaries, peak summit
 */
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region {
  int __pyx_n;
  PyObject *score_cutoff_s;
};

/* "MACS2/IO/CallPeakUnit.pyx":1838
 *         return bpeaks
 * 
 *     cpdef refine_peak_from_tags_distribution ( self, peaks, int32_t window_size = 100, float32_t cutoff = 5 ):             # <<<<<<<<<<<<<<
 *         """Extract tags in peak, then apply func on extracted tags.
 * 
 */
struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution {
  int __pyx_n;
  __pyx_t_5numpy_int32_t window_size;
  __pyx_t_5numpy_float32_t cutoff;
};

/* "MACS2/IO/CallPeakUnit.pyx":294
 * # Classes
 * # ------------------------------------
 * cdef class CallerFromAlignments:             # <<<<<<<<<<<<<<
 *     """A unit to calculate scores and call peaks from alignments --
 *     FWTrack or PETrackI objects.
 */
struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments {
  PyObject_HEAD
  struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_vtab;
  PyObject *treat;
  PyObject *ctrl;
  __pyx_t_5numpy_int32_t d;
  PyObject *ctrl_d_s;
  __pyx_t_5numpy_float32_t treat_scaling_factor;
  PyObject *ctrl_scaling_factor_s;
  __pyx_t_5numpy_float32_t lambda_bg;
  PyObject *chromosomes;
  __pyx_t_5numpy_float64_t pseudocount;
  PyObject *bedGraph_filename_prefix;
  __pyx_t_5numpy_int32_t end_shift;
  PyBoolObject *trackline;
  PyBoolObject *save_bedGraph;
  PyBoolObject *save_SPMR;
  PyBoolObject *no_lambda_flag;
  PyBoolObject *PE_mode;
  PyObject *chr_pos_treat_ctrl;
  PyObject *bedGraph_treat_filename;
  PyObject *bedGraph_control_filename;
  FILE *bedGraph_treat_f;
  FILE *bedGraph_ctrl_f;
  PyObject *pqtable;
  PyBoolObject *pvalue_all_done;
  PyObject *pvalue_npeaks;
  PyObject *pvalue_length;
  __pyx_t_5numpy_float32_t optimal_p_cutoff;
  PyObject *cutoff_analysis_filename;
  __pyx_t_5numpy_float64_t test_time;
  PyObject *pileup_data_files;
};



struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments {
  PyObject *(*destroy)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, int __pyx_skip_dispatch);
  PyObject *(*set_pseudocount)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, __pyx_t_5numpy_float32_t, int __pyx_skip_dispatch);
  PyObject *(*enable_trackline)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, int __pyx_skip_dispatch);
  PyObject *(*__pyx___pileup_treat_ctrl_a_chromosome)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *);
  PyObject *(*__pyx___chrom_pair_treat_ctrl)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *);
  PyArrayObject *(*__pyx___cal_score)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *, PyObject *);
  void (*__pyx___cal_pvalue_qvalue_table)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *);
  void (*__pyx___pre_computes)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes *__pyx_optional_args);
  PyObject *(*call_peaks)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks *__pyx_optional_args);
  void (*__pyx___chrom_call_peak_using_certain_criteria)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, PyBoolObject *, PyBoolObject *);
  PyBoolObject *(*__pyx___close_peak_wo_subpeaks)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks *__pyx_optional_args);
  PyBoolObject *(*__pyx___close_peak_with_subpeaks)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks *__pyx_optional_args);
  PyArrayObject *(*__pyx___cal_pscore)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *);
  PyArrayObject *(*__pyx___cal_qscore)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *);
  PyArrayObject *(*__pyx___cal_logLR)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *);
  PyArrayObject *(*__pyx___cal_logFE)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *);
  PyArrayObject *(*__pyx___cal_FE)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *);
  PyArrayObject *(*__pyx___cal_subtraction)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *);
  PyBoolObject *(*__pyx___write_bedGraph_for_a_chromosome)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *);
  PyObject *(*call_broadpeaks)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks *__pyx_optional_args);
  void (*__pyx___chrom_call_broadpeak_using_certain_criteria)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, PyObject *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, PyBoolObject *);
  PyBoolObject *(*__pyx___close_peak_for_broad_region)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region *__pyx_optional_args);
  PyObject *(*__pyx___add_broadpeak)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, PyObject *);
  PyObject *(*refine_peak_from_tags_distribution)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution *__pyx_optional_args);
};
static struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_vtabptr_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments;

/* --- Runtime support code (head) --- */
/* Refnanny.proto */
#ifndef CYTHON_REFNANNY
  #define CYTHON_REFNANNY 0
#endif
#if CYTHON_REFNANNY
  typedef struct {
    void (*INCREF)(void*, PyObject*, int);
    void (*DECREF)(void*, PyObject*, int);
    void (*GOTREF)(void*, PyObject*, int);
    void (*GIVEREF)(void*, PyObject*, int);
    void* (*SetupContext)(const char*, int, const char*);
    void (*FinishContext)(void**);
  } __Pyx_RefNannyAPIStruct;
  static __Pyx_RefNannyAPIStruct *__Pyx_RefNanny = NULL;
  static __Pyx_RefNannyAPIStruct *__Pyx_RefNannyImportAPI(const char *modname);
  #define __Pyx_RefNannyDeclarations void *__pyx_refnanny = NULL;
#ifdef WITH_THREAD
  #define __Pyx_RefNannySetupContext(name, acquire_gil)\
          if (acquire_gil) {\
              PyGILState_STATE __pyx_gilstate_save = PyGILState_Ensure();\
              __pyx_refnanny = __Pyx_RefNanny->SetupContext((name), __LINE__, __FILE__);\
              PyGILState_Release(__pyx_gilstate_save);\
          } else {\
              __pyx_refnanny = __Pyx_RefNanny->SetupContext((name), __LINE__, __FILE__);\
          }
#else
  #define __Pyx_RefNannySetupContext(name, acquire_gil)\
          __pyx_refnanny = __Pyx_RefNanny->SetupContext((name), __LINE__, __FILE__)
#endif
  #define __Pyx_RefNannyFinishContext()\
          __Pyx_RefNanny->FinishContext(&__pyx_refnanny)
  #define __Pyx_INCREF(r)  __Pyx_RefNanny->INCREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
  #define __Pyx_DECREF(r)  __Pyx_RefNanny->DECREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
  #define __Pyx_GOTREF(r)  __Pyx_RefNanny->GOTREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
  #define __Pyx_GIVEREF(r) __Pyx_RefNanny->GIVEREF(__pyx_refnanny, (PyObject *)(r), __LINE__)
  #define __Pyx_XINCREF(r)  do { if((r) != NULL) {__Pyx_INCREF(r); }} while(0)
  #define __Pyx_XDECREF(r)  do { if((r) != NULL) {__Pyx_DECREF(r); }} while(0)
  #define __Pyx_XGOTREF(r)  do { if((r) != NULL) {__Pyx_GOTREF(r); }} while(0)
  #define __Pyx_XGIVEREF(r) do { if((r) != NULL) {__Pyx_GIVEREF(r);}} while(0)
#else
  #define __Pyx_RefNannyDeclarations
  #define __Pyx_RefNannySetupContext(name, acquire_gil)
  #define __Pyx_RefNannyFinishContext()
  #define __Pyx_INCREF(r) Py_INCREF(r)
  #define __Pyx_DECREF(r) Py_DECREF(r)
  #define __Pyx_GOTREF(r)
  #define __Pyx_GIVEREF(r)
  #define __Pyx_XINCREF(r) Py_XINCREF(r)
  #define __Pyx_XDECREF(r) Py_XDECREF(r)
  #define __Pyx_XGOTREF(r)
  #define __Pyx_XGIVEREF(r)
#endif
#define __Pyx_XDECREF_SET(r, v) do {\
        PyObject *tmp = (PyObject *) r;\
        r = v; __Pyx_XDECREF(tmp);\
    } while (0)
#define __Pyx_DECREF_SET(r, v) do {\
        PyObject *tmp = (PyObject *) r;\
        r = v; __Pyx_DECREF(tmp);\
    } while (0)
#define __Pyx_CLEAR(r)    do { PyObject* tmp = ((PyObject*)(r)); r = NULL; __Pyx_DECREF(tmp);} while(0)
#define __Pyx_XCLEAR(r)   do { if((r) != NULL) {PyObject* tmp = ((PyObject*)(r)); r = NULL; __Pyx_DECREF(tmp);}} while(0)

/* PyObjectGetAttrStr.proto */
#if CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStr(PyObject* obj, PyObject* attr_name);
#else
#define __Pyx_PyObject_GetAttrStr(o,n) PyObject_GetAttr(o,n)
#endif

/* GetBuiltinName.proto */
static PyObject *__Pyx_GetBuiltinName(PyObject *name);

/* PyThreadStateGet.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_PyThreadState_declare  PyThreadState *__pyx_tstate;
#define __Pyx_PyThreadState_assign  __pyx_tstate = __Pyx_PyThreadState_Current;
#define __Pyx_PyErr_Occurred()  __pyx_tstate->curexc_type
#else
#define __Pyx_PyThreadState_declare
#define __Pyx_PyThreadState_assign
#define __Pyx_PyErr_Occurred()  PyErr_Occurred()
#endif

/* PyErrFetchRestore.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_PyErr_Clear() __Pyx_ErrRestore(NULL, NULL, NULL)
#define __Pyx_ErrRestoreWithState(type, value, tb)  __Pyx_ErrRestoreInState(PyThreadState_GET(), type, value, tb)
#define __Pyx_ErrFetchWithState(type, value, tb)    __Pyx_ErrFetchInState(PyThreadState_GET(), type, value, tb)
#define __Pyx_ErrRestore(type, value, tb)  __Pyx_ErrRestoreInState(__pyx_tstate, type, value, tb)
#define __Pyx_ErrFetch(type, value, tb)    __Pyx_ErrFetchInState(__pyx_tstate, type, value, tb)
static CYTHON_INLINE void __Pyx_ErrRestoreInState(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb);
static CYTHON_INLINE void __Pyx_ErrFetchInState(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
#if CYTHON_COMPILING_IN_CPYTHON
#define __Pyx_PyErr_SetNone(exc) (Py_INCREF(exc), __Pyx_ErrRestore((exc), NULL, NULL))
#else
#define __Pyx_PyErr_SetNone(exc) PyErr_SetNone(exc)
#endif
#else
#define __Pyx_PyErr_Clear() PyErr_Clear()
#define __Pyx_PyErr_SetNone(exc) PyErr_SetNone(exc)
#define __Pyx_ErrRestoreWithState(type, value, tb)  PyErr_Restore(type, value, tb)
#define __Pyx_ErrFetchWithState(type, value, tb)  PyErr_Fetch(type, value, tb)
#define __Pyx_ErrRestoreInState(tstate, type, value, tb)  PyErr_Restore(type, value, tb)
#define __Pyx_ErrFetchInState(tstate, type, value, tb)  PyErr_Fetch(type, value, tb)
#define __Pyx_ErrRestore(type, value, tb)  PyErr_Restore(type, value, tb)
#define __Pyx_ErrFetch(type, value, tb)  PyErr_Fetch(type, value, tb)
#endif

/* Profile.proto */
#ifndef CYTHON_PROFILE
#if CYTHON_COMPILING_IN_PYPY || CYTHON_COMPILING_IN_PYSTON
  #define CYTHON_PROFILE 0
#else
  #define CYTHON_PROFILE 1
#endif
#endif
#ifndef CYTHON_TRACE_NOGIL
  #define CYTHON_TRACE_NOGIL 0
#else
  #if CYTHON_TRACE_NOGIL && !defined(CYTHON_TRACE)
    #define CYTHON_TRACE 1
  #endif
#endif
#ifndef CYTHON_TRACE
  #define CYTHON_TRACE 0
#endif
#if CYTHON_TRACE
  #undef CYTHON_PROFILE_REUSE_FRAME
#endif
#ifndef CYTHON_PROFILE_REUSE_FRAME
  #define CYTHON_PROFILE_REUSE_FRAME 0
#endif
#if CYTHON_PROFILE || CYTHON_TRACE
  #include "compile.h"
  #include "frameobject.h"
  #include "traceback.h"
  #if CYTHON_PROFILE_REUSE_FRAME
    #define CYTHON_FRAME_MODIFIER static
    #define CYTHON_FRAME_DEL(frame)
  #else
    #define CYTHON_FRAME_MODIFIER
    #define CYTHON_FRAME_DEL(frame) Py_CLEAR(frame)
  #endif
  #define __Pyx_TraceDeclarations\
  static PyCodeObject *__pyx_frame_code = NULL;\
  CYTHON_FRAME_MODIFIER PyFrameObject *__pyx_frame = NULL;\
  int __Pyx_use_tracing = 0;
  #define __Pyx_TraceFrameInit(codeobj)\
  if (codeobj) __pyx_frame_code = (PyCodeObject*) codeobj;
  #ifdef WITH_THREAD
  #define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)\
  if (nogil) {\
      if (CYTHON_TRACE_NOGIL) {\
          PyThreadState *tstate;\
          PyGILState_STATE state = PyGILState_Ensure();\
          tstate = __Pyx_PyThreadState_Current;\
          if (unlikely(tstate->use_tracing) && !tstate->tracing &&\
                  (tstate->c_profilefunc || (CYTHON_TRACE && tstate->c_tracefunc))) {\
              __Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
          }\
          PyGILState_Release(state);\
          if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
      }\
  } else {\
      PyThreadState* tstate = PyThreadState_GET();\
      if (unlikely(tstate->use_tracing) && !tstate->tracing &&\
              (tstate->c_profilefunc || (CYTHON_TRACE && tstate->c_tracefunc))) {\
          __Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
          if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
      }\
  }
  #else
  #define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)\
  {   PyThreadState* tstate = PyThreadState_GET();\
      if (unlikely(tstate->use_tracing) && !tstate->tracing &&\
              (tstate->c_profilefunc || (CYTHON_TRACE && tstate->c_tracefunc))) {\
          __Pyx_use_tracing = __Pyx_TraceSetupAndCall(&__pyx_frame_code, &__pyx_frame, tstate, funcname, srcfile, firstlineno);\
          if (unlikely(__Pyx_use_tracing < 0)) goto_error;\
      }\
  }
  #endif
  #define __Pyx_TraceException()\
  if (likely(!__Pyx_use_tracing)); else {\
      PyThreadState* tstate = __Pyx_PyThreadState_Current;\
      if (tstate->use_tracing &&\
              (tstate->c_profilefunc || (CYTHON_TRACE && tstate->c_tracefunc))) {\
          tstate->tracing++;\
          tstate->use_tracing = 0;\
          PyObject *exc_info = __Pyx_GetExceptionTuple(tstate);\
          if (exc_info) {\
              if (CYTHON_TRACE && tstate->c_tracefunc)\
                  tstate->c_tracefunc(\
                      tstate->c_traceobj, __pyx_frame, PyTrace_EXCEPTION, exc_info);\
              tstate->c_profilefunc(\
                  tstate->c_profileobj, __pyx_frame, PyTrace_EXCEPTION, exc_info);\
              Py_DECREF(exc_info);\
          }\
          tstate->use_tracing = 1;\
          tstate->tracing--;\
      }\
  }
  static void __Pyx_call_return_trace_func(PyThreadState *tstate, PyFrameObject *frame, PyObject *result) {
      PyObject *type, *value, *traceback;
      __Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
      tstate->tracing++;
      tstate->use_tracing = 0;
      if (CYTHON_TRACE && tstate->c_tracefunc)
          tstate->c_tracefunc(tstate->c_traceobj, frame, PyTrace_RETURN, result);
      if (tstate->c_profilefunc)
          tstate->c_profilefunc(tstate->c_profileobj, frame, PyTrace_RETURN, result);
      CYTHON_FRAME_DEL(frame);
      tstate->use_tracing = 1;
      tstate->tracing--;
      __Pyx_ErrRestoreInState(tstate, type, value, traceback);
  }
  #ifdef WITH_THREAD
  #define __Pyx_TraceReturn(result, nogil)\
  if (likely(!__Pyx_use_tracing)); else {\
      if (nogil) {\
          if (CYTHON_TRACE_NOGIL) {\
              PyThreadState *tstate;\
              PyGILState_STATE state = PyGILState_Ensure();\
              tstate = __Pyx_PyThreadState_Current;\
              if (tstate->use_tracing) {\
                  __Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
              }\
              PyGILState_Release(state);\
          }\
      } else {\
          PyThreadState* tstate = __Pyx_PyThreadState_Current;\
          if (tstate->use_tracing) {\
              __Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
          }\
      }\
  }
  #else
  #define __Pyx_TraceReturn(result, nogil)\
  if (likely(!__Pyx_use_tracing)); else {\
      PyThreadState* tstate = __Pyx_PyThreadState_Current;\
      if (tstate->use_tracing) {\
          __Pyx_call_return_trace_func(tstate, __pyx_frame, (PyObject*)result);\
      }\
  }
  #endif
  static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno);
  static int __Pyx_TraceSetupAndCall(PyCodeObject** code, PyFrameObject** frame, PyThreadState* tstate, const char *funcname, const char *srcfile, int firstlineno);
#else
  #define __Pyx_TraceDeclarations
  #define __Pyx_TraceFrameInit(codeobj)
  #define __Pyx_TraceCall(funcname, srcfile, firstlineno, nogil, goto_error)   if ((1)); else goto_error;
  #define __Pyx_TraceException()
  #define __Pyx_TraceReturn(result, nogil)
#endif
#if CYTHON_TRACE
  static int __Pyx_call_line_trace_func(PyThreadState *tstate, PyFrameObject *frame, int lineno) {
      int ret;
      PyObject *type, *value, *traceback;
      __Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
      __Pyx_PyFrame_SetLineNumber(frame, lineno);
      tstate->tracing++;
      tstate->use_tracing = 0;
      ret = tstate->c_tracefunc(tstate->c_traceobj, frame, PyTrace_LINE, NULL);
      tstate->use_tracing = 1;
      tstate->tracing--;
      if (likely(!ret)) {
          __Pyx_ErrRestoreInState(tstate, type, value, traceback);
      } else {
          Py_XDECREF(type);
          Py_XDECREF(value);
          Py_XDECREF(traceback);
      }
      return ret;
  }
  #ifdef WITH_THREAD
  #define __Pyx_TraceLine(lineno, nogil, goto_error)\
  if (likely(!__Pyx_use_tracing)); else {\
      if (nogil) {\
          if (CYTHON_TRACE_NOGIL) {\
              int ret = 0;\
              PyThreadState *tstate;\
              PyGILState_STATE state = PyGILState_Ensure();\
              tstate = __Pyx_PyThreadState_Current;\
              if (unlikely(tstate->use_tracing && tstate->c_tracefunc && __pyx_frame->f_trace)) {\
                  ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
              }\
              PyGILState_Release(state);\
              if (unlikely(ret)) goto_error;\
          }\
      } else {\
          PyThreadState* tstate = __Pyx_PyThreadState_Current;\
          if (unlikely(tstate->use_tracing && tstate->c_tracefunc && __pyx_frame->f_trace)) {\
              int ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
              if (unlikely(ret)) goto_error;\
          }\
      }\
  }
  #else
  #define __Pyx_TraceLine(lineno, nogil, goto_error)\
  if (likely(!__Pyx_use_tracing)); else {\
      PyThreadState* tstate = __Pyx_PyThreadState_Current;\
      if (unlikely(tstate->use_tracing && tstate->c_tracefunc && __pyx_frame->f_trace)) {\
          int ret = __Pyx_call_line_trace_func(tstate, __pyx_frame, lineno);\
          if (unlikely(ret)) goto_error;\
      }\
  }
  #endif
#else
  #define __Pyx_TraceLine(lineno, nogil, goto_error)   if ((1)); else goto_error;
#endif

/* PyDictVersioning.proto */
#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_TYPE_SLOTS
#define __PYX_DICT_VERSION_INIT  ((PY_UINT64_T) -1)
#define __PYX_GET_DICT_VERSION(dict)  (((PyDictObject*)(dict))->ma_version_tag)
#define __PYX_UPDATE_DICT_CACHE(dict, value, cache_var, version_var)\
    (version_var) = __PYX_GET_DICT_VERSION(dict);\
    (cache_var) = (value);
#define __PYX_PY_DICT_LOOKUP_IF_MODIFIED(VAR, DICT, LOOKUP) {\
    static PY_UINT64_T __pyx_dict_version = 0;\
    static PyObject *__pyx_dict_cached_value = NULL;\
    if (likely(__PYX_GET_DICT_VERSION(DICT) == __pyx_dict_version)) {\
        (VAR) = __pyx_dict_cached_value;\
    } else {\
        (VAR) = __pyx_dict_cached_value = (LOOKUP);\
        __pyx_dict_version = __PYX_GET_DICT_VERSION(DICT);\
    }\
}
static CYTHON_INLINE PY_UINT64_T __Pyx_get_tp_dict_version(PyObject *obj);
static CYTHON_INLINE PY_UINT64_T __Pyx_get_object_dict_version(PyObject *obj);
static CYTHON_INLINE int __Pyx_object_dict_version_matches(PyObject* obj, PY_UINT64_T tp_dict_version, PY_UINT64_T obj_dict_version);
#else
#define __PYX_GET_DICT_VERSION(dict)  (0)
#define __PYX_UPDATE_DICT_CACHE(dict, value, cache_var, version_var)
#define __PYX_PY_DICT_LOOKUP_IF_MODIFIED(VAR, DICT, LOOKUP)  (VAR) = (LOOKUP);
#endif

/* GetModuleGlobalName.proto */
#if CYTHON_USE_DICT_VERSIONS
#define __Pyx_GetModuleGlobalName(var, name)  {\
    static PY_UINT64_T __pyx_dict_version = 0;\
    static PyObject *__pyx_dict_cached_value = NULL;\
    (var) = (likely(__pyx_dict_version == __PYX_GET_DICT_VERSION(__pyx_d))) ?\
        (likely(__pyx_dict_cached_value) ? __Pyx_NewRef(__pyx_dict_cached_value) : __Pyx_GetBuiltinName(name)) :\
        __Pyx__GetModuleGlobalName(name, &__pyx_dict_version, &__pyx_dict_cached_value);\
}
#define __Pyx_GetModuleGlobalNameUncached(var, name)  {\
    PY_UINT64_T __pyx_dict_version;\
    PyObject *__pyx_dict_cached_value;\
    (var) = __Pyx__GetModuleGlobalName(name, &__pyx_dict_version, &__pyx_dict_cached_value);\
}
static PyObject *__Pyx__GetModuleGlobalName(PyObject *name, PY_UINT64_T *dict_version, PyObject **dict_cached_value);
#else
#define __Pyx_GetModuleGlobalName(var, name)  (var) = __Pyx__GetModuleGlobalName(name)
#define __Pyx_GetModuleGlobalNameUncached(var, name)  (var) = __Pyx__GetModuleGlobalName(name)
static CYTHON_INLINE PyObject *__Pyx__GetModuleGlobalName(PyObject *name);
#endif

/* PySequenceContains.proto */
static CYTHON_INLINE int __Pyx_PySequence_ContainsTF(PyObject* item, PyObject* seq, int eq) {
    int result = PySequence_Contains(seq, item);
    return unlikely(result < 0) ? result : (result == (eq == Py_EQ));
}

/* GetItemInt.proto */
#define __Pyx_GetItemInt(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
    (__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
    __Pyx_GetItemInt_Fast(o, (Py_ssize_t)i, is_list, wraparound, boundscheck) :\
    (is_list ? (PyErr_SetString(PyExc_IndexError, "list index out of range"), (PyObject*)NULL) :\
               __Pyx_GetItemInt_Generic(o, to_py_func(i))))
#define __Pyx_GetItemInt_List(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
    (__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
    __Pyx_GetItemInt_List_Fast(o, (Py_ssize_t)i, wraparound, boundscheck) :\
    (PyErr_SetString(PyExc_IndexError, "list index out of range"), (PyObject*)NULL))
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i,
                                                              int wraparound, int boundscheck);
#define __Pyx_GetItemInt_Tuple(o, i, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
    (__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
    __Pyx_GetItemInt_Tuple_Fast(o, (Py_ssize_t)i, wraparound, boundscheck) :\
    (PyErr_SetString(PyExc_IndexError, "tuple index out of range"), (PyObject*)NULL))
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i,
                                                              int wraparound, int boundscheck);
static PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j);
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i,
                                                     int is_list, int wraparound, int boundscheck);

/* ObjectGetItem.proto */
#if CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PyObject *__Pyx_PyObject_GetItem(PyObject *obj, PyObject* key);
#else
#define __Pyx_PyObject_GetItem(obj, key)  PyObject_GetItem(obj, key)
#endif

/* PyFunctionFastCall.proto */
#if CYTHON_FAST_PYCALL
#define __Pyx_PyFunction_FastCall(func, args, nargs)\
    __Pyx_PyFunction_FastCallDict((func), (args), (nargs), NULL)
#if 1 || PY_VERSION_HEX < 0x030600B1
static PyObject *__Pyx_PyFunction_FastCallDict(PyObject *func, PyObject **args, Py_ssize_t nargs, PyObject *kwargs);
#else
#define __Pyx_PyFunction_FastCallDict(func, args, nargs, kwargs) _PyFunction_FastCallDict(func, args, nargs, kwargs)
#endif
#define __Pyx_BUILD_ASSERT_EXPR(cond)\
    (sizeof(char [1 - 2*!(cond)]) - 1)
#ifndef Py_MEMBER_SIZE
#define Py_MEMBER_SIZE(type, member) sizeof(((type *)0)->member)
#endif
  static size_t __pyx_pyframe_localsplus_offset = 0;
  #include "frameobject.h"
  #define __Pxy_PyFrame_Initialize_Offsets()\
    ((void)__Pyx_BUILD_ASSERT_EXPR(sizeof(PyFrameObject) == offsetof(PyFrameObject, f_localsplus) + Py_MEMBER_SIZE(PyFrameObject, f_localsplus)),\
     (void)(__pyx_pyframe_localsplus_offset = ((size_t)PyFrame_Type.tp_basicsize) - Py_MEMBER_SIZE(PyFrameObject, f_localsplus)))
  #define __Pyx_PyFrame_GetLocalsplus(frame)\
    (assert(__pyx_pyframe_localsplus_offset), (PyObject **)(((char *)(frame)) + __pyx_pyframe_localsplus_offset))
#endif

/* PyCFunctionFastCall.proto */
#if CYTHON_FAST_PYCCALL
static CYTHON_INLINE PyObject *__Pyx_PyCFunction_FastCall(PyObject *func, PyObject **args, Py_ssize_t nargs);
#else
#define __Pyx_PyCFunction_FastCall(func, args, nargs)  (assert(0), NULL)
#endif

/* PyObjectCall.proto */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_Call(PyObject *func, PyObject *arg, PyObject *kw);
#else
#define __Pyx_PyObject_Call(func, arg, kw) PyObject_Call(func, arg, kw)
#endif

/* WriteUnraisableException.proto */
static void __Pyx_WriteUnraisable(const char *name, int clineno,
                                  int lineno, const char *filename,
                                  int full_traceback, int nogil);

/* None.proto */
static CYTHON_INLINE long __Pyx_div_long(long, long);

/* ExtTypeTest.proto */
static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type);

/* ListAppend.proto */
#if CYTHON_USE_PYLIST_INTERNALS && CYTHON_ASSUME_SAFE_MACROS
static CYTHON_INLINE int __Pyx_PyList_Append(PyObject* list, PyObject* x) {
    PyListObject* L = (PyListObject*) list;
    Py_ssize_t len = Py_SIZE(list);
    if (likely(L->allocated > len) & likely(len > (L->allocated >> 1))) {
        Py_INCREF(x);
        PyList_SET_ITEM(list, len, x);
        Py_SIZE(list) = len+1;
        return 0;
    }
    return PyList_Append(list, x);
}
#else
#define __Pyx_PyList_Append(L,x) PyList_Append(L,x)
#endif

/* ListCompAppend.proto */
#if CYTHON_USE_PYLIST_INTERNALS && CYTHON_ASSUME_SAFE_MACROS
static CYTHON_INLINE int __Pyx_ListComp_Append(PyObject* list, PyObject* x) {
    PyListObject* L = (PyListObject*) list;
    Py_ssize_t len = Py_SIZE(list);
    if (likely(L->allocated > len)) {
        Py_INCREF(x);
        PyList_SET_ITEM(list, len, x);
        Py_SIZE(list) = len+1;
        return 0;
    }
    return PyList_Append(list, x);
}
#else
#define __Pyx_ListComp_Append(L,x) PyList_Append(L,x)
#endif

/* DictGetItem.proto */
#if PY_MAJOR_VERSION >= 3 && !CYTHON_COMPILING_IN_PYPY
static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key);
#define __Pyx_PyObject_Dict_GetItem(obj, name)\
    (likely(PyDict_CheckExact(obj)) ?\
     __Pyx_PyDict_GetItem(obj, name) : PyObject_GetItem(obj, name))
#else
#define __Pyx_PyDict_GetItem(d, key) PyObject_GetItem(d, key)
#define __Pyx_PyObject_Dict_GetItem(obj, name)  PyObject_GetItem(obj, name)
#endif

/* SetItemInt.proto */
#define __Pyx_SetItemInt(o, i, v, type, is_signed, to_py_func, is_list, wraparound, boundscheck)\
    (__Pyx_fits_Py_ssize_t(i, type, is_signed) ?\
    __Pyx_SetItemInt_Fast(o, (Py_ssize_t)i, v, is_list, wraparound, boundscheck) :\
    (is_list ? (PyErr_SetString(PyExc_IndexError, "list assignment index out of range"), -1) :\
               __Pyx_SetItemInt_Generic(o, to_py_func(i), v)))
static int __Pyx_SetItemInt_Generic(PyObject *o, PyObject *j, PyObject *v);
static CYTHON_INLINE int __Pyx_SetItemInt_Fast(PyObject *o, Py_ssize_t i, PyObject *v,
                                               int is_list, int wraparound, int boundscheck);

/* PyObjectCallMethO.proto */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallMethO(PyObject *func, PyObject *arg);
#endif

/* PyObjectCallOneArg.proto */
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallOneArg(PyObject *func, PyObject *arg);

/* PyObjectCall2Args.proto */
static CYTHON_UNUSED PyObject* __Pyx_PyObject_Call2Args(PyObject* function, PyObject* arg1, PyObject* arg2);

/* IsLittleEndian.proto */
static CYTHON_INLINE int __Pyx_Is_Little_Endian(void);

/* BufferFormatCheck.proto */
static const char* __Pyx_BufFmt_CheckString(__Pyx_BufFmt_Context* ctx, const char* ts);
static void __Pyx_BufFmt_Init(__Pyx_BufFmt_Context* ctx,
                              __Pyx_BufFmt_StackElem* stack,
                              __Pyx_TypeInfo* type);

/* BufferGetAndValidate.proto */
#define __Pyx_GetBufferAndValidate(buf, obj, dtype, flags, nd, cast, stack)\
    ((obj == Py_None || obj == NULL) ?\
    (__Pyx_ZeroBuffer(buf), 0) :\
    __Pyx__GetBufferAndValidate(buf, obj, dtype, flags, nd, cast, stack))
static int  __Pyx__GetBufferAndValidate(Py_buffer* buf, PyObject* obj,
    __Pyx_TypeInfo* dtype, int flags, int nd, int cast, __Pyx_BufFmt_StackElem* stack);
static void __Pyx_ZeroBuffer(Py_buffer* buf);
static CYTHON_INLINE void __Pyx_SafeReleaseBuffer(Py_buffer* info);
static Py_ssize_t __Pyx_minusones[] = { -1, -1, -1, -1, -1, -1, -1, -1 };
static Py_ssize_t __Pyx_zeros[] = { 0, 0, 0, 0, 0, 0, 0, 0 };

/* PyIntBinop.proto */
#if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyInt_TrueDivideObjC(PyObject *op1, PyObject *op2, long intval, int inplace, int zerodivision_check);
#else
#define __Pyx_PyInt_TrueDivideObjC(op1, op2, intval, inplace, zerodivision_check)\
    (inplace ? PyNumber_InPlaceTrueDivide(op1, op2) : PyNumber_TrueDivide(op1, op2))
#endif

/* RaiseTooManyValuesToUnpack.proto */
static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected);

/* RaiseNeedMoreValuesToUnpack.proto */
static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index);

/* IterFinish.proto */
static CYTHON_INLINE int __Pyx_IterFinish(void);

/* UnpackItemEndCheck.proto */
static int __Pyx_IternextUnpackEndCheck(PyObject *retval, Py_ssize_t expected);

/* BufferIndexError.proto */
static void __Pyx_RaiseBufferIndexError(int axis);

#define __Pyx_BufPtrStrided1d(type, buf, i0, s0) (type)((char*)buf + i0 * s0)
/* SliceObject.proto */
static CYTHON_INLINE PyObject* __Pyx_PyObject_GetSlice(
        PyObject* obj, Py_ssize_t cstart, Py_ssize_t cstop,
        PyObject** py_start, PyObject** py_stop, PyObject** py_slice,
        int has_cstart, int has_cstop, int wraparound);

/* RaiseArgTupleInvalid.proto */
static void __Pyx_RaiseArgtupleInvalid(const char* func_name, int exact,
    Py_ssize_t num_min, Py_ssize_t num_max, Py_ssize_t num_found);

/* RaiseDoubleKeywords.proto */
static void __Pyx_RaiseDoubleKeywordsError(const char* func_name, PyObject* kw_name);

/* ParseKeywords.proto */
static int __Pyx_ParseOptionalKeywords(PyObject *kwds, PyObject **argnames[],\
    PyObject *kwds2, PyObject *values[], Py_ssize_t num_pos_args,\
    const char* function_name);

/* ArgTypeTest.proto */
#define __Pyx_ArgTypeTest(obj, type, none_allowed, name, exact)\
    ((likely((Py_TYPE(obj) == type) | (none_allowed && (obj == Py_None)))) ? 1 :\
        __Pyx__ArgTypeTest(obj, type, name, exact))
static int __Pyx__ArgTypeTest(PyObject *obj, PyTypeObject *type, const char *name, int exact);

/* RaiseException.proto */
static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause);

/* PyObjectCallNoArg.proto */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallNoArg(PyObject *func);
#else
#define __Pyx_PyObject_CallNoArg(func) __Pyx_PyObject_Call(func, __pyx_empty_tuple, NULL)
#endif

/* UnpackUnboundCMethod.proto */
typedef struct {
    PyObject *type;
    PyObject **method_name;
    PyCFunction func;
    PyObject *method;
    int flag;
} __Pyx_CachedCFunction;

/* CallUnboundCMethod1.proto */
static PyObject* __Pyx__CallUnboundCMethod1(__Pyx_CachedCFunction* cfunc, PyObject* self, PyObject* arg);
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_CallUnboundCMethod1(__Pyx_CachedCFunction* cfunc, PyObject* self, PyObject* arg);
#else
#define __Pyx_CallUnboundCMethod1(cfunc, self, arg)  __Pyx__CallUnboundCMethod1(cfunc, self, arg)
#endif

/* PyObjectGetMethod.proto */
static int __Pyx_PyObject_GetMethod(PyObject *obj, PyObject *name, PyObject **method);

/* PyObjectCallMethod0.proto */
static PyObject* __Pyx_PyObject_CallMethod0(PyObject* obj, PyObject* method_name);

/* RaiseNoneIterError.proto */
static CYTHON_INLINE void __Pyx_RaiseNoneNotIterableError(void);

/* UnpackTupleError.proto */
static void __Pyx_UnpackTupleError(PyObject *, Py_ssize_t index);

/* UnpackTuple2.proto */
#define __Pyx_unpack_tuple2(tuple, value1, value2, is_tuple, has_known_size, decref_tuple)\
    (likely(is_tuple || PyTuple_Check(tuple)) ?\
        (likely(has_known_size || PyTuple_GET_SIZE(tuple) == 2) ?\
            __Pyx_unpack_tuple2_exact(tuple, value1, value2, decref_tuple) :\
            (__Pyx_UnpackTupleError(tuple, 2), -1)) :\
        __Pyx_unpack_tuple2_generic(tuple, value1, value2, has_known_size, decref_tuple))
static CYTHON_INLINE int __Pyx_unpack_tuple2_exact(
    PyObject* tuple, PyObject** value1, PyObject** value2, int decref_tuple);
static int __Pyx_unpack_tuple2_generic(
    PyObject* tuple, PyObject** value1, PyObject** value2, int has_known_size, int decref_tuple);

/* dict_iter.proto */
static CYTHON_INLINE PyObject* __Pyx_dict_iterator(PyObject* dict, int is_dict, PyObject* method_name,
                                                   Py_ssize_t* p_orig_length, int* p_is_dict);
static CYTHON_INLINE int __Pyx_dict_iter_next(PyObject* dict_or_iter, Py_ssize_t orig_length, Py_ssize_t* ppos,
                                              PyObject** pkey, PyObject** pvalue, PyObject** pitem, int is_dict);

/* PyDictContains.proto */
static CYTHON_INLINE int __Pyx_PyDict_ContainsTF(PyObject* item, PyObject* dict, int eq) {
    int result = PyDict_Contains(dict, item);
    return unlikely(result < 0) ? result : (result == (eq == Py_EQ));
}

/* GetTopmostException.proto */
#if CYTHON_USE_EXC_INFO_STACK
static _PyErr_StackItem * __Pyx_PyErr_GetTopmostException(PyThreadState *tstate);
#endif

/* SaveResetException.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_ExceptionSave(type, value, tb)  __Pyx__ExceptionSave(__pyx_tstate, type, value, tb)
static CYTHON_INLINE void __Pyx__ExceptionSave(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
#define __Pyx_ExceptionReset(type, value, tb)  __Pyx__ExceptionReset(__pyx_tstate, type, value, tb)
static CYTHON_INLINE void __Pyx__ExceptionReset(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb);
#else
#define __Pyx_ExceptionSave(type, value, tb)   PyErr_GetExcInfo(type, value, tb)
#define __Pyx_ExceptionReset(type, value, tb)  PyErr_SetExcInfo(type, value, tb)
#endif

/* GetException.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_GetException(type, value, tb)  __Pyx__GetException(__pyx_tstate, type, value, tb)
static int __Pyx__GetException(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb);
#else
static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb);
#endif

/* py_dict_pop.proto */
static CYTHON_INLINE PyObject *__Pyx_PyDict_Pop(PyObject *d, PyObject *key, PyObject *default_value);

/* CallUnboundCMethod2.proto */
static PyObject* __Pyx__CallUnboundCMethod2(__Pyx_CachedCFunction* cfunc, PyObject* self, PyObject* arg1, PyObject* arg2);
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030600B1
static CYTHON_INLINE PyObject *__Pyx_CallUnboundCMethod2(__Pyx_CachedCFunction *cfunc, PyObject *self, PyObject *arg1, PyObject *arg2);
#else
#define __Pyx_CallUnboundCMethod2(cfunc, self, arg1, arg2)  __Pyx__CallUnboundCMethod2(cfunc, self, arg1, arg2)
#endif

/* BufferFallbackError.proto */
static void __Pyx_RaiseBufferFallbackError(void);

/* py_dict_values.proto */
static CYTHON_INLINE PyObject* __Pyx_PyDict_Values(PyObject* d);

/* CallUnboundCMethod0.proto */
static PyObject* __Pyx__CallUnboundCMethod0(__Pyx_CachedCFunction* cfunc, PyObject* self);
#if CYTHON_COMPILING_IN_CPYTHON
#define __Pyx_CallUnboundCMethod0(cfunc, self)\
    (likely((cfunc)->func) ?\
        (likely((cfunc)->flag == METH_NOARGS) ?  (*((cfunc)->func))(self, NULL) :\
         (PY_VERSION_HEX >= 0x030600B1 && likely((cfunc)->flag == METH_FASTCALL) ?\
            (PY_VERSION_HEX >= 0x030700A0 ?\
                (*(__Pyx_PyCFunctionFast)(void*)(PyCFunction)(cfunc)->func)(self, &__pyx_empty_tuple, 0) :\
                (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)(cfunc)->func)(self, &__pyx_empty_tuple, 0, NULL)) :\
          (PY_VERSION_HEX >= 0x030700A0 && (cfunc)->flag == (METH_FASTCALL | METH_KEYWORDS) ?\
            (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)(cfunc)->func)(self, &__pyx_empty_tuple, 0, NULL) :\
            (likely((cfunc)->flag == (METH_VARARGS | METH_KEYWORDS)) ?  ((*(PyCFunctionWithKeywords)(void*)(PyCFunction)(cfunc)->func)(self, __pyx_empty_tuple, NULL)) :\
               ((cfunc)->flag == METH_VARARGS ?  (*((cfunc)->func))(self, __pyx_empty_tuple) :\
               __Pyx__CallUnboundCMethod0(cfunc, self)))))) :\
        __Pyx__CallUnboundCMethod0(cfunc, self))
#else
#define __Pyx_CallUnboundCMethod0(cfunc, self)  __Pyx__CallUnboundCMethod0(cfunc, self)
#endif

/* py_dict_keys.proto */
static CYTHON_INLINE PyObject* __Pyx_PyDict_Keys(PyObject* d);

/* PyIntCompare.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_EqObjC(PyObject *op1, PyObject *op2, long intval, long inplace);

/* dict_getitem_default.proto */
static PyObject* __Pyx_PyDict_GetItemDefault(PyObject* d, PyObject* key, PyObject* default_value);

/* PyObjectFormat.proto */
#if CYTHON_USE_UNICODE_WRITER
static PyObject* __Pyx_PyObject_Format(PyObject* s, PyObject* f);
#else
#define __Pyx_PyObject_Format(s, f) PyObject_Format(s, f)
#endif

/* IncludeStringH.proto */
#include <string.h>

/* JoinPyUnicode.proto */
static PyObject* __Pyx_PyUnicode_Join(PyObject* value_tuple, Py_ssize_t value_count, Py_ssize_t result_ulength,
                                      Py_UCS4 max_char);

/* decode_c_string_utf16.proto */
static CYTHON_INLINE PyObject *__Pyx_PyUnicode_DecodeUTF16(const char *s, Py_ssize_t size, const char *errors) {
    int byteorder = 0;
    return PyUnicode_DecodeUTF16(s, size, errors, &byteorder);
}
static CYTHON_INLINE PyObject *__Pyx_PyUnicode_DecodeUTF16LE(const char *s, Py_ssize_t size, const char *errors) {
    int byteorder = -1;
    return PyUnicode_DecodeUTF16(s, size, errors, &byteorder);
}
static CYTHON_INLINE PyObject *__Pyx_PyUnicode_DecodeUTF16BE(const char *s, Py_ssize_t size, const char *errors) {
    int byteorder = 1;
    return PyUnicode_DecodeUTF16(s, size, errors, &byteorder);
}

/* decode_c_bytes.proto */
static CYTHON_INLINE PyObject* __Pyx_decode_c_bytes(
         const char* cstring, Py_ssize_t length, Py_ssize_t start, Py_ssize_t stop,
         const char* encoding, const char* errors,
         PyObject* (*decode_func)(const char *s, Py_ssize_t size, const char *errors));

/* decode_bytes.proto */
static CYTHON_INLINE PyObject* __Pyx_decode_bytes(
         PyObject* string, Py_ssize_t start, Py_ssize_t stop,
         const char* encoding, const char* errors,
         PyObject* (*decode_func)(const char *s, Py_ssize_t size, const char *errors)) {
    return __Pyx_decode_c_bytes(
        PyBytes_AS_STRING(string), PyBytes_GET_SIZE(string),
        start, stop, encoding, errors, decode_func);
}

/* BytesEquals.proto */
static CYTHON_INLINE int __Pyx_PyBytes_Equals(PyObject* s1, PyObject* s2, int equals);

/* UnicodeEquals.proto */
static CYTHON_INLINE int __Pyx_PyUnicode_Equals(PyObject* s1, PyObject* s2, int equals);

/* None.proto */
static CYTHON_INLINE void __Pyx_RaiseUnboundLocalError(const char *varname);

/* None.proto */
static CYTHON_INLINE Py_ssize_t __Pyx_div_Py_ssize_t(Py_ssize_t, Py_ssize_t);

/* PyIntBinop.proto */
#if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyInt_AddObjC(PyObject *op1, PyObject *op2, long intval, int inplace, int zerodivision_check);
#else
#define __Pyx_PyInt_AddObjC(op1, op2, intval, inplace, zerodivision_check)\
    (inplace ? PyNumber_InPlaceAdd(op1, op2) : PyNumber_Add(op1, op2))
#endif

/* PyIntBinop.proto */
#if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyInt_SubtractObjC(PyObject *op1, PyObject *op2, long intval, int inplace, int zerodivision_check);
#else
#define __Pyx_PyInt_SubtractObjC(op1, op2, intval, inplace, zerodivision_check)\
    (inplace ? PyNumber_InPlaceSubtract(op1, op2) : PyNumber_Subtract(op1, op2))
#endif

/* PyFloatBinop.proto */
#if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyFloat_TrueDivideObjC(PyObject *op1, PyObject *op2, double floatval, int inplace, int zerodivision_check);
#else
#define __Pyx_PyFloat_TrueDivideObjC(op1, op2, floatval, inplace, zerodivision_check)\
    (inplace ? PyNumber_InPlaceTrueDivide(op1, op2) : PyNumber_TrueDivide(op1, op2))
#endif

/* set_iter.proto */
static CYTHON_INLINE PyObject* __Pyx_set_iterator(PyObject* iterable, int is_set,
                                                  Py_ssize_t* p_orig_length, int* p_source_is_set);
static CYTHON_INLINE int __Pyx_set_iter_next(
        PyObject* iter_obj, Py_ssize_t orig_length,
        Py_ssize_t* ppos, PyObject **value,
        int source_is_set);

/* PyErrExceptionMatches.proto */
#if CYTHON_FAST_THREAD_STATE
#define __Pyx_PyErr_ExceptionMatches(err) __Pyx_PyErr_ExceptionMatchesInState(__pyx_tstate, err)
static CYTHON_INLINE int __Pyx_PyErr_ExceptionMatchesInState(PyThreadState* tstate, PyObject* err);
#else
#define __Pyx_PyErr_ExceptionMatches(err)  PyErr_ExceptionMatches(err)
#endif

/* StringJoin.proto */
#if PY_MAJOR_VERSION < 3
#define __Pyx_PyString_Join __Pyx_PyBytes_Join
#define __Pyx_PyBaseString_Join(s, v) (PyUnicode_CheckExact(s) ? PyUnicode_Join(s, v) : __Pyx_PyBytes_Join(s, v))
#else
#define __Pyx_PyString_Join PyUnicode_Join
#define __Pyx_PyBaseString_Join PyUnicode_Join
#endif
#if CYTHON_COMPILING_IN_CPYTHON
    #if PY_MAJOR_VERSION < 3
    #define __Pyx_PyBytes_Join _PyString_Join
    #else
    #define __Pyx_PyBytes_Join _PyBytes_Join
    #endif
#else
static CYTHON_INLINE PyObject* __Pyx_PyBytes_Join(PyObject* sep, PyObject* values);
#endif

/* pyfrozenset_new.proto */
static CYTHON_INLINE PyObject* __Pyx_PyFrozenSet_New(PyObject* it);

/* PySetContains.proto */
static CYTHON_INLINE int __Pyx_PySet_ContainsTF(PyObject* key, PyObject* set, int eq);

/* PyObject_GenericGetAttrNoDict.proto */
#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static CYTHON_INLINE PyObject* __Pyx_PyObject_GenericGetAttrNoDict(PyObject* obj, PyObject* attr_name);
#else
#define __Pyx_PyObject_GenericGetAttrNoDict PyObject_GenericGetAttr
#endif

/* PyObject_GenericGetAttr.proto */
#if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static PyObject* __Pyx_PyObject_GenericGetAttr(PyObject* obj, PyObject* attr_name);
#else
#define __Pyx_PyObject_GenericGetAttr PyObject_GenericGetAttr
#endif

/* SetVTable.proto */
static int __Pyx_SetVtable(PyObject *dict, void *vtable);

/* SetupReduce.proto */
static int __Pyx_setup_reduce(PyObject* type_obj);

/* TypeImport.proto */
#ifndef __PYX_HAVE_RT_ImportType_proto
#define __PYX_HAVE_RT_ImportType_proto
enum __Pyx_ImportType_CheckSize {
   __Pyx_ImportType_CheckSize_Error = 0,
   __Pyx_ImportType_CheckSize_Warn = 1,
   __Pyx_ImportType_CheckSize_Ignore = 2
};
static PyTypeObject *__Pyx_ImportType(PyObject* module, const char *module_name, const char *class_name, size_t size, enum __Pyx_ImportType_CheckSize check_size);
#endif

/* Import.proto */
static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list, int level);

/* ImportFrom.proto */
static PyObject* __Pyx_ImportFrom(PyObject* module, PyObject* name);

/* CLineInTraceback.proto */
#ifdef CYTHON_CLINE_IN_TRACEBACK
#define __Pyx_CLineForTraceback(tstate, c_line)  (((CYTHON_CLINE_IN_TRACEBACK)) ? c_line : 0)
#else
static int __Pyx_CLineForTraceback(PyThreadState *tstate, int c_line);
#endif

/* CodeObjectCache.proto */
typedef struct {
    PyCodeObject* code_object;
    int code_line;
} __Pyx_CodeObjectCacheEntry;
struct __Pyx_CodeObjectCache {
    int count;
    int max_count;
    __Pyx_CodeObjectCacheEntry* entries;
};
static struct __Pyx_CodeObjectCache __pyx_code_cache = {0,0,NULL};
static int __pyx_bisect_code_objects(__Pyx_CodeObjectCacheEntry* entries, int count, int code_line);
static PyCodeObject *__pyx_find_code_object(int code_line);
static void __pyx_insert_code_object(int code_line, PyCodeObject* code_object);

/* AddTraceback.proto */
static void __Pyx_AddTraceback(const char *funcname, int c_line,
                               int py_line, const char *filename);

/* BufferStructDeclare.proto */
typedef struct {
  Py_ssize_t shape, strides, suboffsets;
} __Pyx_Buf_DimInfo;
typedef struct {
  size_t refcount;
  Py_buffer pybuffer;
} __Pyx_Buffer;
typedef struct {
  __Pyx_Buffer *rcbuffer;
  char *data;
  __Pyx_Buf_DimInfo diminfo[8];
} __Pyx_LocalBuf_ND;

#if PY_MAJOR_VERSION < 3
    static int __Pyx_GetBuffer(PyObject *obj, Py_buffer *view, int flags);
    static void __Pyx_ReleaseBuffer(Py_buffer *view);
#else
    #define __Pyx_GetBuffer PyObject_GetBuffer
    #define __Pyx_ReleaseBuffer PyBuffer_Release
#endif


/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_long(long value);

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_npy_int64(npy_int64 value);

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_npy_int32(npy_int32 value);

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_Py_intptr_t(Py_intptr_t value);

/* RealImag.proto */
#if CYTHON_CCOMPLEX
  #ifdef __cplusplus
    #define __Pyx_CREAL(z) ((z).real())
    #define __Pyx_CIMAG(z) ((z).imag())
  #else
    #define __Pyx_CREAL(z) (__real__(z))
    #define __Pyx_CIMAG(z) (__imag__(z))
  #endif
#else
    #define __Pyx_CREAL(z) ((z).real)
    #define __Pyx_CIMAG(z) ((z).imag)
#endif
#if defined(__cplusplus) && CYTHON_CCOMPLEX\
        && (defined(_WIN32) || defined(__clang__) || (defined(__GNUC__) && (__GNUC__ >= 5 || __GNUC__ == 4 && __GNUC_MINOR__ >= 4 )) || __cplusplus >= 201103)
    #define __Pyx_SET_CREAL(z,x) ((z).real(x))
    #define __Pyx_SET_CIMAG(z,y) ((z).imag(y))
#else
    #define __Pyx_SET_CREAL(z,x) __Pyx_CREAL(z) = (x)
    #define __Pyx_SET_CIMAG(z,y) __Pyx_CIMAG(z) = (y)
#endif

/* Arithmetic.proto */
#if CYTHON_CCOMPLEX
    #define __Pyx_c_eq_float(a, b)   ((a)==(b))
    #define __Pyx_c_sum_float(a, b)  ((a)+(b))
    #define __Pyx_c_diff_float(a, b) ((a)-(b))
    #define __Pyx_c_prod_float(a, b) ((a)*(b))
    #define __Pyx_c_quot_float(a, b) ((a)/(b))
    #define __Pyx_c_neg_float(a)     (-(a))
  #ifdef __cplusplus
    #define __Pyx_c_is_zero_float(z) ((z)==(float)0)
    #define __Pyx_c_conj_float(z)    (::std::conj(z))
    #if 1
        #define __Pyx_c_abs_float(z)     (::std::abs(z))
        #define __Pyx_c_pow_float(a, b)  (::std::pow(a, b))
    #endif
  #else
    #define __Pyx_c_is_zero_float(z) ((z)==0)
    #define __Pyx_c_conj_float(z)    (conjf(z))
    #if 1
        #define __Pyx_c_abs_float(z)     (cabsf(z))
        #define __Pyx_c_pow_float(a, b)  (cpowf(a, b))
    #endif
 #endif
#else
    static CYTHON_INLINE int __Pyx_c_eq_float(__pyx_t_float_complex, __pyx_t_float_complex);
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_sum_float(__pyx_t_float_complex, __pyx_t_float_complex);
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_diff_float(__pyx_t_float_complex, __pyx_t_float_complex);
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_prod_float(__pyx_t_float_complex, __pyx_t_float_complex);
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_quot_float(__pyx_t_float_complex, __pyx_t_float_complex);
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_neg_float(__pyx_t_float_complex);
    static CYTHON_INLINE int __Pyx_c_is_zero_float(__pyx_t_float_complex);
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_conj_float(__pyx_t_float_complex);
    #if 1
        static CYTHON_INLINE float __Pyx_c_abs_float(__pyx_t_float_complex);
        static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_pow_float(__pyx_t_float_complex, __pyx_t_float_complex);
    #endif
#endif

/* Arithmetic.proto */
#if CYTHON_CCOMPLEX
    #define __Pyx_c_eq_double(a, b)   ((a)==(b))
    #define __Pyx_c_sum_double(a, b)  ((a)+(b))
    #define __Pyx_c_diff_double(a, b) ((a)-(b))
    #define __Pyx_c_prod_double(a, b) ((a)*(b))
    #define __Pyx_c_quot_double(a, b) ((a)/(b))
    #define __Pyx_c_neg_double(a)     (-(a))
  #ifdef __cplusplus
    #define __Pyx_c_is_zero_double(z) ((z)==(double)0)
    #define __Pyx_c_conj_double(z)    (::std::conj(z))
    #if 1
        #define __Pyx_c_abs_double(z)     (::std::abs(z))
        #define __Pyx_c_pow_double(a, b)  (::std::pow(a, b))
    #endif
  #else
    #define __Pyx_c_is_zero_double(z) ((z)==0)
    #define __Pyx_c_conj_double(z)    (conj(z))
    #if 1
        #define __Pyx_c_abs_double(z)     (cabs(z))
        #define __Pyx_c_pow_double(a, b)  (cpow(a, b))
    #endif
 #endif
#else
    static CYTHON_INLINE int __Pyx_c_eq_double(__pyx_t_double_complex, __pyx_t_double_complex);
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_sum_double(__pyx_t_double_complex, __pyx_t_double_complex);
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_diff_double(__pyx_t_double_complex, __pyx_t_double_complex);
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_prod_double(__pyx_t_double_complex, __pyx_t_double_complex);
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_quot_double(__pyx_t_double_complex, __pyx_t_double_complex);
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_neg_double(__pyx_t_double_complex);
    static CYTHON_INLINE int __Pyx_c_is_zero_double(__pyx_t_double_complex);
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_conj_double(__pyx_t_double_complex);
    #if 1
        static CYTHON_INLINE double __Pyx_c_abs_double(__pyx_t_double_complex);
        static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_pow_double(__pyx_t_double_complex, __pyx_t_double_complex);
    #endif
#endif

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int(int value);

/* CIntToPy.proto */
static CYTHON_INLINE PyObject* __Pyx_PyInt_From_enum__NPY_TYPES(enum NPY_TYPES value);

/* CIntFromPy.proto */
static CYTHON_INLINE npy_int32 __Pyx_PyInt_As_npy_int32(PyObject *);

/* CIntFromPy.proto */
static CYTHON_INLINE npy_int64 __Pyx_PyInt_As_npy_int64(PyObject *);

/* CIntFromPy.proto */
static CYTHON_INLINE long __Pyx_PyInt_As_long(PyObject *);

/* CIntFromPy.proto */
static CYTHON_INLINE int __Pyx_PyInt_As_int(PyObject *);

/* FastTypeChecks.proto */
#if CYTHON_COMPILING_IN_CPYTHON
#define __Pyx_TypeCheck(obj, type) __Pyx_IsSubtype(Py_TYPE(obj), (PyTypeObject *)type)
static CYTHON_INLINE int __Pyx_IsSubtype(PyTypeObject *a, PyTypeObject *b);
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches(PyObject *err, PyObject *type);
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches2(PyObject *err, PyObject *type1, PyObject *type2);
#else
#define __Pyx_TypeCheck(obj, type) PyObject_TypeCheck(obj, (PyTypeObject *)type)
#define __Pyx_PyErr_GivenExceptionMatches(err, type) PyErr_GivenExceptionMatches(err, type)
#define __Pyx_PyErr_GivenExceptionMatches2(err, type1, type2) (PyErr_GivenExceptionMatches(err, type1) || PyErr_GivenExceptionMatches(err, type2))
#endif
#define __Pyx_PyException_Check(obj) __Pyx_TypeCheck(obj, PyExc_Exception)

/* CheckBinaryVersion.proto */
static int __Pyx_check_binary_version(void);

/* InitStrings.proto */
static int __Pyx_InitStrings(__Pyx_StringTabEntry *t);

static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_destroy(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, int __pyx_skip_dispatch); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_set_pseudocount(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, __pyx_t_5numpy_float32_t __pyx_v_pseudocount, int __pyx_skip_dispatch); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_enable_trackline(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, int __pyx_skip_dispatch); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pileup_treat_ctrl_a_chromosome(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_chrom); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_pair_treat_ctrl(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_treat_pv, PyObject *__pyx_v_ctrl_pv); /* proto*/
static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_score(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2, PyObject *__pyx_v_cal_func); /* proto*/
static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_pvalue_qvalue_table(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self); /* proto*/
static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes *__pyx_optional_args); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_score_cutoff_s, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks *__pyx_optional_args); /* proto*/
static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_call_peak_using_certain_criteria(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peaks, PyObject *__pyx_v_chrom, PyObject *__pyx_v_scoring_function_s, PyObject *__pyx_v_score_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_max_gap, PyBoolObject *__pyx_v_call_summits, PyBoolObject *__pyx_v_save_bedGraph); /* proto*/
static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peak_content, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_min_length, PyObject *__pyx_v_chrom, CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_smoothlen, PyObject *__pyx_v_score_array_s, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks *__pyx_optional_args); /* proto*/
static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peak_content, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_min_length, PyObject *__pyx_v_chrom, __pyx_t_5numpy_int32_t __pyx_v_smoothlen, PyObject *__pyx_v_score_array_s, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks *__pyx_optional_args); /* proto*/
static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_pscore(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2); /* proto*/
static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_qscore(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2); /* proto*/
static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_logLR(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2); /* proto*/
static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_logFE(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2); /* proto*/
static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_FE(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2); /* proto*/
static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_subtraction(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2); /* proto*/
static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___write_bedGraph_for_a_chromosome(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_chrom); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_lvl1_cutoff_s, PyObject *__pyx_v_lvl2_cutoff_s, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks *__pyx_optional_args); /* proto*/
static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_call_broadpeak_using_certain_criteria(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_lvl1peaks, PyObject *__pyx_v_lvl2peaks, PyObject *__pyx_v_chrom, PyObject *__pyx_v_scoring_function_s, PyObject *__pyx_v_lvl1_cutoff_s, PyObject *__pyx_v_lvl2_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_lvl1_max_gap, __pyx_t_5numpy_int32_t __pyx_v_lvl2_max_gap, PyBoolObject *__pyx_v_save_bedGraph); /* proto*/
static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peak_content, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_min_length, PyObject *__pyx_v_chrom, CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_smoothlen, CYTHON_UNUSED PyObject *__pyx_v_score_array_s, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region *__pyx_optional_args); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___add_broadpeak(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_bpeaks, PyObject *__pyx_v_chrom, PyObject *__pyx_v_lvl2peak, PyObject *__pyx_v_lvl1peakset); /* proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peaks, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution *__pyx_optional_args); /* proto*/

/* Module declarations from 'cpython.buffer' */

/* Module declarations from 'libc.string' */

/* Module declarations from 'libc.stdio' */

/* Module declarations from '__builtin__' */

/* Module declarations from 'cpython.type' */
static PyTypeObject *__pyx_ptype_7cpython_4type_type = 0;

/* Module declarations from 'cpython.version' */

/* Module declarations from 'cpython.exc' */

/* Module declarations from 'cpython.module' */

/* Module declarations from 'cpython.mem' */

/* Module declarations from 'cpython.tuple' */

/* Module declarations from 'cpython.list' */

/* Module declarations from 'cpython.sequence' */

/* Module declarations from 'cpython.mapping' */

/* Module declarations from 'cpython.iterator' */

/* Module declarations from 'cpython.number' */

/* Module declarations from 'cpython.int' */

/* Module declarations from '__builtin__' */

/* Module declarations from 'cpython.bool' */
static PyTypeObject *__pyx_ptype_7cpython_4bool_bool = 0;

/* Module declarations from 'cpython.long' */

/* Module declarations from 'cpython.float' */

/* Module declarations from '__builtin__' */

/* Module declarations from 'cpython.complex' */
static PyTypeObject *__pyx_ptype_7cpython_7complex_complex = 0;

/* Module declarations from 'cpython.string' */

/* Module declarations from 'cpython.unicode' */

/* Module declarations from 'cpython.dict' */

/* Module declarations from 'cpython.instance' */

/* Module declarations from 'cpython.function' */

/* Module declarations from 'cpython.method' */

/* Module declarations from 'cpython.weakref' */

/* Module declarations from 'cpython.getargs' */

/* Module declarations from 'cpython.pythread' */

/* Module declarations from 'cpython.pystate' */

/* Module declarations from 'cpython.cobject' */

/* Module declarations from 'cpython.oldbuffer' */

/* Module declarations from 'cpython.set' */

/* Module declarations from 'cpython.bytes' */

/* Module declarations from 'cpython.pycapsule' */

/* Module declarations from 'cpython' */

/* Module declarations from 'cpython.object' */

/* Module declarations from 'cpython.ref' */

/* Module declarations from 'numpy' */

/* Module declarations from 'numpy' */
static PyTypeObject *__pyx_ptype_5numpy_dtype = 0;
static PyTypeObject *__pyx_ptype_5numpy_flatiter = 0;
static PyTypeObject *__pyx_ptype_5numpy_broadcast = 0;
static PyTypeObject *__pyx_ptype_5numpy_ndarray = 0;
static PyTypeObject *__pyx_ptype_5numpy_ufunc = 0;
static CYTHON_INLINE char *__pyx_f_5numpy__util_dtypestring(PyArray_Descr *, char *, char *, int *); /*proto*/

/* Module declarations from 'libc.math' */

/* Module declarations from 'MACS2.IO.CallPeakUnit' */
static PyTypeObject *__pyx_ptype_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments = 0;
static __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_get_pscore(PyObject *); /*proto*/
static __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_get_logLR_asym(__pyx_t_5numpy_float32_t, __pyx_t_5numpy_float32_t); /*proto*/
static void __pyx_f_5MACS2_2IO_12CallPeakUnit_clean_up_ndarray(PyArrayObject *); /*proto*/
static CYTHON_INLINE PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_apply_multiple_cutoffs(PyObject *, PyObject *); /*proto*/
static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_get_logFE(__pyx_t_5numpy_float32_t, __pyx_t_5numpy_float32_t); /*proto*/
static CYTHON_INLINE PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_getitem_then_subtract(PyObject *, __pyx_t_5numpy_int32_t); /*proto*/
static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_left_sum(PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t); /*proto*/
static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_right_sum(PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t); /*proto*/
static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_left_forward(PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t); /*proto*/
static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_right_forward(PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t); /*proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_wtd_find_summit(PyObject *, PyArrayObject *, PyArrayObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_float32_t); /*proto*/
static __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_mean_from_value_length(PyArrayObject *, PyObject *); /*proto*/
static __Pyx_TypeInfo __Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t = { "float32_t", NULL, sizeof(__pyx_t_5numpy_float32_t), { 0 }, 0, 'R', 0, 0 };
static __Pyx_TypeInfo __Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t = { "int32_t", NULL, sizeof(__pyx_t_5numpy_int32_t), { 0 }, 0, IS_UNSIGNED(__pyx_t_5numpy_int32_t) ? 'U' : 'I', IS_UNSIGNED(__pyx_t_5numpy_int32_t), 0 };
#define __Pyx_MODULE_NAME "MACS2.IO.CallPeakUnit"
extern int __pyx_module_is_main_MACS2__IO__CallPeakUnit;
int __pyx_module_is_main_MACS2__IO__CallPeakUnit = 0;

/* Implementation of 'MACS2.IO.CallPeakUnit' */
static PyObject *__pyx_builtin_range;
static PyObject *__pyx_builtin_sum;
static PyObject *__pyx_builtin_zip;
static PyObject *__pyx_builtin_open;
static PyObject *__pyx_builtin_sorted;
static PyObject *__pyx_builtin_round;
static PyObject *__pyx_builtin_StopIteration;
static PyObject *__pyx_builtin_TypeError;
static PyObject *__pyx_builtin_ValueError;
static PyObject *__pyx_builtin_RuntimeError;
static PyObject *__pyx_builtin_ImportError;
static const char __pyx_k_0[] = "0,";
static const char __pyx_k_1[] = "1,";
static const char __pyx_k_T[] = "T";
static const char __pyx_k_d[] = "d";
static const char __pyx_k_f[] = "f";
static const char __pyx_k_p[] = "p";
static const char __pyx_k_q[] = "q";
static const char __pyx_k_s[] = "s";
static const char __pyx_k_w[] = "w";
static const char __pyx_k_2f[] = ".2f";
static const char __pyx_k__9[] = "\t";
static const char __pyx_k_fc[] = "fc";
static const char __pyx_k_np[] = "np";
static const char __pyx_k_os[] = "os";
static const char __pyx_k_rb[] = "rb";
static const char __pyx_k_wb[] = "wb";
static const char __pyx_k_0_d[] = "0,%d";
static const char __pyx_k_1_1[] = "1,1";
static const char __pyx_k_1_2[] = ",1";
static const char __pyx_k__10[] = "\n";
static const char __pyx_k__13[] = ",";
static const char __pyx_k_add[] = "add";
static const char __pyx_k_d_2[] = "%d";
static const char __pyx_k_doc[] = "__doc__";
static const char __pyx_k_end[] = "end";
static const char __pyx_k_get[] = "get";
static const char __pyx_k_pop[] = "pop";
static const char __pyx_k_sum[] = "sum";
static const char __pyx_k_zip[] = "zip";
static const char __pyx_k_copy[] = "copy";
static const char __pyx_k_ctrl[] = "ctrl";
static const char __pyx_k_dump[] = "dump";
static const char __pyx_k_info[] = "info";
static const char __pyx_k_join[] = "join";
static const char __pyx_k_keys[] = "keys";
static const char __pyx_k_load[] = "load";
static const char __pyx_k_main[] = "__main__";
static const char __pyx_k_mean[] = "mean";
static const char __pyx_k_name[] = "__name__";
static const char __pyx_k_next[] = "__next__";
static const char __pyx_k_ones[] = "ones";
static const char __pyx_k_open[] = "open";
static const char __pyx_k_path[] = "path";
static const char __pyx_k_size[] = "size";
static const char __pyx_k_sort[] = "sort";
static const char __pyx_k_test[] = "__test__";
static const char __pyx_k_time[] = "time";
static const char __pyx_k_array[] = "array";
static const char __pyx_k_close[] = "close";
static const char __pyx_k_debug[] = "debug";
static const char __pyx_k_dtype[] = "dtype";
static const char __pyx_k_int32[] = "int32";
static const char __pyx_k_log10[] = "log10";
static const char __pyx_k_lstsq[] = "lstsq";
static const char __pyx_k_numpy[] = "numpy";
static const char __pyx_k_peaks[] = "peaks";
static const char __pyx_k_range[] = "range";
static const char __pyx_k_rcond[] = "rcond";
static const char __pyx_k_right[] = "right";
static const char __pyx_k_round[] = "round";
static const char __pyx_k_score[] = "score";
static const char __pyx_k_start[] = "start";
static const char __pyx_k_total[] = "total";
static const char __pyx_k_treat[] = "treat";
static const char __pyx_k_ttime[] = "ttime";
static const char __pyx_k_write[] = "write";
static const char __pyx_k_zeros[] = "zeros";
static const char __pyx_k_PREFIX[] = "PREFIX";
static const char __pyx_k_PeakIO[] = "PeakIO";
static const char __pyx_k_arange[] = "arange";
static const char __pyx_k_author[] = "__author__";
static const char __pyx_k_cutoff[] = "cutoff";
static const char __pyx_k_import[] = "__import__";
static const char __pyx_k_isfile[] = "isfile";
static const char __pyx_k_length[] = "length";
static const char __pyx_k_linalg[] = "linalg";
static const char __pyx_k_maxima[] = "maxima";
static const char __pyx_k_pickle[] = "_pickle";
static const char __pyx_k_pileup[] = "pileup";
static const char __pyx_k_pscore[] = "pscore";
static const char __pyx_k_qscore[] = "qscore";
static const char __pyx_k_reduce[] = "__reduce__";
static const char __pyx_k_resize[] = "resize";
static const char __pyx_k_sorted[] = "sorted";
static const char __pyx_k_summit[] = "summit";
static const char __pyx_k_unlink[] = "unlink";
static const char __pyx_k_values[] = "values";
static const char __pyx_k_vstack[] = "vstack";
static const char __pyx_k_Counter[] = "Counter";
static const char __pyx_k_FWTrack[] = "FWTrack";
static const char __pyx_k_LOG10_E[] = "LOG10_E";
static const char __pyx_k_TMP_txt[] = "TMP.txt";
static const char __pyx_k_cPickle[] = "cPickle";
static const char __pyx_k_destroy[] = "destroy";
static const char __pyx_k_float32[] = "float32";
static const char __pyx_k_logging[] = "logging";
static const char __pyx_k_max_gap[] = "max_gap";
static const char __pyx_k_mkstemp[] = "mkstemp";
static const char __pyx_k_nonzero[] = "nonzero";
static const char __pyx_k_reverse[] = "reverse";
static const char __pyx_k_version[] = "__version__";
static const char __pyx_k_CTRL_bdg[] = "CTRL.bdg";
static const char __pyx_k_PETrackI[] = "PETrackI";
static const char __pyx_k_blockNum[] = "blockNum";
static const char __pyx_k_ctrl_d_s[] = "ctrl_d_s";
static const char __pyx_k_getstate[] = "__getstate__";
static const char __pyx_k_protocol[] = "protocol";
static const char __pyx_k_refcheck[] = "refcheck";
static const char __pyx_k_setstate[] = "__setstate__";
static const char __pyx_k_sorted_2[] = "__sorted";
static const char __pyx_k_tempfile[] = "tempfile";
static const char __pyx_k_thickEnd[] = "thickEnd";
static const char __pyx_k_TREAT_bdg[] = "TREAT.bdg";
static const char __pyx_k_TypeError[] = "TypeError";
static const char __pyx_k_end_shift[] = "end_shift";
static const char __pyx_k_lambda_bg[] = "lambda_bg";
static const char __pyx_k_locations[] = "__locations";
static const char __pyx_k_reduce_ex[] = "__reduce_ex__";
static const char __pyx_k_save_SPMR[] = "save_SPMR";
static const char __pyx_k_stderr_on[] = "stderr_on";
static const char __pyx_k_MACS2_Prob[] = "MACS2.Prob";
static const char __pyx_k_ValueError[] = "ValueError";
static const char __pyx_k_blockSizes[] = "blockSizes";
static const char __pyx_k_call_peaks[] = "call_peaks";
static const char __pyx_k_logLR_dict[] = "logLR_dict";
static const char __pyx_k_min_length[] = "min_length";
static const char __pyx_k_peak_score[] = "peak_score";
static const char __pyx_k_pyx_vtable[] = "__pyx_vtable__";
static const char __pyx_k_thickStart[] = "thickStart";
static const char __pyx_k_BroadPeakIO[] = "BroadPeakIO";
static const char __pyx_k_ImportError[] = "ImportError";
static const char __pyx_k_blockStarts[] = "blockStarts";
static const char __pyx_k_collections[] = "collections";
static const char __pyx_k_directional[] = "directional";
static const char __pyx_k_fold_change[] = "fold_change";
static const char __pyx_k_poisson_cdf[] = "poisson_cdf";
static const char __pyx_k_pscore_dict[] = "pscore_dict";
static const char __pyx_k_pseudocount[] = "pseudocount";
static const char __pyx_k_window_size[] = "window_size";
static const char __pyx_k_CallPeakUnit[] = "CallPeakUnit";
static const char __pyx_k_MACS2_Signal[] = "MACS2.Signal";
static const char __pyx_k_RuntimeError[] = "RuntimeError";
static const char __pyx_k_call_summits[] = "call_summits";
static const char __pyx_k_intersection[] = "intersection";
static const char __pyx_k_lvl1_max_gap[] = "lvl1_max_gap";
static const char __pyx_k_lvl2_max_gap[] = "lvl2_max_gap";
static const char __pyx_k_searchsorted[] = "searchsorted";
static const char __pyx_k_StopIteration[] = "StopIteration";
static const char __pyx_k_get_chr_names[] = "get_chr_names";
static const char __pyx_k_lvl1_cutoff_s[] = "lvl1_cutoff_s";
static const char __pyx_k_lvl2_cutoff_s[] = "lvl2_cutoff_s";
static const char __pyx_k_reduce_cython[] = "__reduce_cython__";
static const char __pyx_k_save_bedGraph[] = "save_bedGraph";
static const char __pyx_k_baseline_value[] = "baseline_value";
static const char __pyx_k_parse_peakname[] = "parse_peakname";
static const char __pyx_k_score_cutoff_s[] = "score_cutoff_s";
static const char __pyx_k_MACS2_IO_PeakIO[] = "MACS2.IO.PeakIO";
static const char __pyx_k_add_PeakContent[] = "add_PeakContent";
static const char __pyx_k_call_broadpeaks[] = "call_broadpeaks";
static const char __pyx_k_cutoff_analysis[] = "cutoff_analysis";
static const char __pyx_k_enforce_valleys[] = "enforce_valleys";
static const char __pyx_k_set_pseudocount[] = "set_pseudocount";
static const char __pyx_k_setstate_cython[] = "__setstate_cython__";
static const char __pyx_k_enable_trackline[] = "enable_trackline";
static const char __pyx_k_treat_pileup_bdg[] = "_treat_pileup.bdg";
static const char __pyx_k_enforce_peakyness[] = "enforce_peakyness";
static const char __pyx_k_cline_in_traceback[] = "cline_in_traceback";
static const char __pyx_k_control_lambda_bdg[] = "_control_lambda.bdg";
static const char __pyx_k_get_data_from_chrom[] = "get_data_from_chrom";
static const char __pyx_k_pileup_a_chromosome[] = "pileup_a_chromosome";
static const char __pyx_k_CallerFromAlignments[] = "CallerFromAlignments";
static const char __pyx_k_treat_scaling_factor[] = "treat_scaling_factor";
static const char __pyx_k_CallPeakUnit_Revision[] = "CallPeakUnit $Revision$";
static const char __pyx_k_ctrl_scaling_factor_s[] = "ctrl_scaling_factor_s";
static const char __pyx_k_pileup_a_chromosome_c[] = "pileup_a_chromosome_c";
static const char __pyx_k_MACS2_IO_FixWidthTrack[] = "MACS2.IO.FixWidthTrack";
static const char __pyx_k_MACS2_IO_PairedEndTrack[] = "MACS2.IO.PairedEndTrack";
static const char __pyx_k_bedGraph_treat_filename[] = "bedGraph_treat_filename";
static const char __pyx_k_bedGraph_filename_prefix[] = "bedGraph_filename_prefix";
static const char __pyx_k_cutoff_analysis_filename[] = "cutoff_analysis_filename";
static const char __pyx_k_scoring_function_symbols[] = "scoring_function_symbols";
static const char __pyx_k_bedGraph_control_filename[] = "bedGraph_control_filename";
static const char __pyx_k_chromosome_s_is_not_valid[] = "chromosome %s is not valid.";
static const char __pyx_k_access_pq_hash_for_d_times[] = "access pq hash for %d times";
static const char __pyx_k_ndarray_is_not_C_contiguous[] = "ndarray is not C contiguous";
static const char __pyx_k_3_Analysis_of_cutoff_vs_num_of[] = "#3 Analysis of cutoff vs num of peaks or total length has been saved in %s";
static const char __pyx_k_3_Cutoff_value_vs_broad_region[] = "#3 Cutoff value vs broad region calls will be analyzed!";
static const char __pyx_k_3_In_the_peak_calling_step_the[] = "#3 In the peak calling step, the following will be performed simultaneously:";
static const char __pyx_k_Start_to_calculate_pvalue_stat[] = "Start to calculate pvalue stat...";
static const char __pyx_k_Tao_Liu_vladimir_liu_gmail_com[] = "Tao Liu <vladimir.liu@gmail.com>";
static const char __pyx_k_3_Call_peaks_for_each_chromosom[] = "#3 Call peaks for each chromosome...";
static const char __pyx_k_3_Cutoff_vs_peaks_called_will_b[] = "#3 Cutoff vs peaks called will be analyzed!";
static const char __pyx_k_3_Pileup_will_be_based_on_seque[] = "#3   Pileup will be based on sequencing depth in treatment.";
static const char __pyx_k_3_Pre_compute_pvalue_qvalue_tab[] = "#3 Pre-compute pvalue-qvalue table...";
static const char __pyx_k_3_SPMR_is_requested_so_pileup_w[] = "#3   --SPMR is requested, so pileup will be normalized by sequencing depth in million reads.";
static const char __pyx_k_3_Write_bedGraph_files_for_cont[] = "#3   Write bedGraph files for control lambda (after scaling if necessary)... %s";
static const char __pyx_k_3_Write_bedGraph_files_for_trea[] = "#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s";
static const char __pyx_k_number_of_functions_and_cutoffs[] = "number of functions and cutoffs should be the same!";
static const char __pyx_k_numpy_core_multiarray_failed_to[] = "numpy.core.multiarray failed to import";
static const char __pyx_k_unknown_dtype_code_in_numpy_pxd[] = "unknown dtype code in numpy.pxd (%d)";
static const char __pyx_k_Format_string_allocated_too_shor[] = "Format string allocated too short, see comment in numpy.pxd";
static const char __pyx_k_Module_for_Calculate_Scores_This[] = "Module for Calculate Scores.\n\nThis code is free software; you can redistribute it and/or modify it\nunder the terms of the BSD License (see the file LICENSE included with\nthe distribution).\n";
static const char __pyx_k_Non_native_byte_order_not_suppor[] = "Non-native byte order not supported";
static const char __pyx_k_Should_be_FWTrack_or_PETrackI_ob[] = "Should be FWTrack or PETrackI object!";
static const char __pyx_k_chromosome_s_can_t_be_found_in_t[] = "chromosome %s can't be found in the FWTrack object.";
static const char __pyx_k_ndarray_is_not_Fortran_contiguou[] = "ndarray is not Fortran contiguous";
static const char __pyx_k_numpy_core_umath_failed_to_impor[] = "numpy.core.umath failed to import";
static const char __pyx_k_pscore_qscore_npeaks_lpeaks_avel[] = "pscore\tqscore\tnpeaks\tlpeaks\tavelpeak\n";
static const char __pyx_k_refine_peak_from_tags_distributi[] = "refine_peak_from_tags_distribution";
static const char __pyx_k_self_bedGraph_ctrl_f_self_bedGra[] = "self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling";
static const char __pyx_k_track_type_bedGraph_name_control[] = "track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for '%s'\"\n";
static const char __pyx_k_track_type_bedGraph_name_treatme[] = "track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for '%s'\"\n";
static const char __pyx_k_3_Pileup_will_be_based_on_seque_2[] = "#3   Pileup will be based on sequencing depth in control.";
static const char __pyx_k_Format_string_allocated_too_shor_2[] = "Format string allocated too short.";
static PyObject *__pyx_kp_b_0;
static PyObject *__pyx_kp_b_0_d;
static PyObject *__pyx_kp_b_1;
static PyObject *__pyx_kp_b_1_1;
static PyObject *__pyx_kp_b_1_2;
static PyObject *__pyx_kp_u_2f;
static PyObject *__pyx_kp_u_3_Analysis_of_cutoff_vs_num_of;
static PyObject *__pyx_kp_u_3_Call_peaks_for_each_chromosom;
static PyObject *__pyx_kp_u_3_Cutoff_value_vs_broad_region;
static PyObject *__pyx_kp_u_3_Cutoff_vs_peaks_called_will_b;
static PyObject *__pyx_kp_u_3_In_the_peak_calling_step_the;
static PyObject *__pyx_kp_u_3_Pileup_will_be_based_on_seque;
static PyObject *__pyx_kp_u_3_Pileup_will_be_based_on_seque_2;
static PyObject *__pyx_kp_u_3_Pre_compute_pvalue_qvalue_tab;
static PyObject *__pyx_kp_u_3_SPMR_is_requested_so_pileup_w;
static PyObject *__pyx_kp_u_3_Write_bedGraph_files_for_cont;
static PyObject *__pyx_kp_u_3_Write_bedGraph_files_for_trea;
static PyObject *__pyx_n_s_BroadPeakIO;
static PyObject *__pyx_kp_u_CTRL_bdg;
static PyObject *__pyx_n_u_CallPeakUnit;
static PyObject *__pyx_kp_u_CallPeakUnit_Revision;
static PyObject *__pyx_n_s_CallerFromAlignments;
static PyObject *__pyx_n_s_Counter;
static PyObject *__pyx_n_s_FWTrack;
static PyObject *__pyx_kp_u_Format_string_allocated_too_shor;
static PyObject *__pyx_kp_u_Format_string_allocated_too_shor_2;
static PyObject *__pyx_n_s_ImportError;
static PyObject *__pyx_n_s_LOG10_E;
static PyObject *__pyx_n_s_MACS2_IO_FixWidthTrack;
static PyObject *__pyx_n_s_MACS2_IO_PairedEndTrack;
static PyObject *__pyx_n_s_MACS2_IO_PeakIO;
static PyObject *__pyx_n_s_MACS2_Prob;
static PyObject *__pyx_n_s_MACS2_Signal;
static PyObject *__pyx_kp_u_Non_native_byte_order_not_suppor;
static PyObject *__pyx_n_s_PETrackI;
static PyObject *__pyx_n_u_PREFIX;
static PyObject *__pyx_n_s_PeakIO;
static PyObject *__pyx_n_s_RuntimeError;
static PyObject *__pyx_kp_u_Should_be_FWTrack_or_PETrackI_ob;
static PyObject *__pyx_kp_u_Start_to_calculate_pvalue_stat;
static PyObject *__pyx_n_s_StopIteration;
static PyObject *__pyx_n_s_T;
static PyObject *__pyx_kp_u_TMP_txt;
static PyObject *__pyx_kp_u_TREAT_bdg;
static PyObject *__pyx_kp_u_Tao_Liu_vladimir_liu_gmail_com;
static PyObject *__pyx_n_s_TypeError;
static PyObject *__pyx_n_s_ValueError;
static PyObject *__pyx_kp_u__10;
static PyObject *__pyx_kp_b__13;
static PyObject *__pyx_kp_u__9;
static PyObject *__pyx_kp_u_access_pq_hash_for_d_times;
static PyObject *__pyx_n_s_add;
static PyObject *__pyx_n_s_add_PeakContent;
static PyObject *__pyx_n_s_arange;
static PyObject *__pyx_n_s_array;
static PyObject *__pyx_n_s_author;
static PyObject *__pyx_n_s_baseline_value;
static PyObject *__pyx_n_s_bedGraph_control_filename;
static PyObject *__pyx_n_s_bedGraph_filename_prefix;
static PyObject *__pyx_n_s_bedGraph_treat_filename;
static PyObject *__pyx_n_s_blockNum;
static PyObject *__pyx_n_s_blockSizes;
static PyObject *__pyx_n_s_blockStarts;
static PyObject *__pyx_n_s_cPickle;
static PyObject *__pyx_n_s_call_broadpeaks;
static PyObject *__pyx_n_s_call_peaks;
static PyObject *__pyx_n_s_call_summits;
static PyObject *__pyx_kp_u_chromosome_s_can_t_be_found_in_t;
static PyObject *__pyx_kp_u_chromosome_s_is_not_valid;
static PyObject *__pyx_n_s_cline_in_traceback;
static PyObject *__pyx_n_s_close;
static PyObject *__pyx_n_s_collections;
static PyObject *__pyx_kp_u_control_lambda_bdg;
static PyObject *__pyx_n_s_copy;
static PyObject *__pyx_n_s_ctrl;
static PyObject *__pyx_n_s_ctrl_d_s;
static PyObject *__pyx_n_s_ctrl_scaling_factor_s;
static PyObject *__pyx_n_s_cutoff;
static PyObject *__pyx_n_s_cutoff_analysis;
static PyObject *__pyx_n_s_cutoff_analysis_filename;
static PyObject *__pyx_n_s_d;
static PyObject *__pyx_n_u_d;
static PyObject *__pyx_kp_b_d_2;
static PyObject *__pyx_n_s_debug;
static PyObject *__pyx_n_s_destroy;
static PyObject *__pyx_n_s_directional;
static PyObject *__pyx_n_s_doc;
static PyObject *__pyx_n_s_dtype;
static PyObject *__pyx_n_s_dump;
static PyObject *__pyx_n_s_enable_trackline;
static PyObject *__pyx_n_u_end;
static PyObject *__pyx_n_s_end_shift;
static PyObject *__pyx_n_s_enforce_peakyness;
static PyObject *__pyx_n_s_enforce_valleys;
static PyObject *__pyx_n_u_f;
static PyObject *__pyx_n_u_fc;
static PyObject *__pyx_n_u_float32;
static PyObject *__pyx_n_s_fold_change;
static PyObject *__pyx_n_s_get;
static PyObject *__pyx_n_s_get_chr_names;
static PyObject *__pyx_n_s_get_data_from_chrom;
static PyObject *__pyx_n_s_getstate;
static PyObject *__pyx_n_s_import;
static PyObject *__pyx_n_s_info;
static PyObject *__pyx_n_u_int32;
static PyObject *__pyx_n_s_intersection;
static PyObject *__pyx_n_s_isfile;
static PyObject *__pyx_n_s_join;
static PyObject *__pyx_n_s_keys;
static PyObject *__pyx_n_s_lambda_bg;
static PyObject *__pyx_n_u_length;
static PyObject *__pyx_n_s_linalg;
static PyObject *__pyx_n_s_load;
static PyObject *__pyx_n_s_locations;
static PyObject *__pyx_n_s_log10;
static PyObject *__pyx_n_s_logLR_dict;
static PyObject *__pyx_n_s_logging;
static PyObject *__pyx_n_s_lstsq;
static PyObject *__pyx_n_s_lvl1_cutoff_s;
static PyObject *__pyx_n_s_lvl1_max_gap;
static PyObject *__pyx_n_s_lvl2_cutoff_s;
static PyObject *__pyx_n_s_lvl2_max_gap;
static PyObject *__pyx_n_s_main;
static PyObject *__pyx_n_s_max_gap;
static PyObject *__pyx_n_s_maxima;
static PyObject *__pyx_n_s_mean;
static PyObject *__pyx_n_s_min_length;
static PyObject *__pyx_n_s_mkstemp;
static PyObject *__pyx_n_s_name;
static PyObject *__pyx_kp_u_ndarray_is_not_C_contiguous;
static PyObject *__pyx_kp_u_ndarray_is_not_Fortran_contiguou;
static PyObject *__pyx_n_s_next;
static PyObject *__pyx_n_s_nonzero;
static PyObject *__pyx_n_s_np;
static PyObject *__pyx_kp_u_number_of_functions_and_cutoffs;
static PyObject *__pyx_n_s_numpy;
static PyObject *__pyx_kp_u_numpy_core_multiarray_failed_to;
static PyObject *__pyx_kp_u_numpy_core_umath_failed_to_impor;
static PyObject *__pyx_n_s_ones;
static PyObject *__pyx_n_s_open;
static PyObject *__pyx_n_s_os;
static PyObject *__pyx_n_u_p;
static PyObject *__pyx_n_s_parse_peakname;
static PyObject *__pyx_n_s_path;
static PyObject *__pyx_n_s_peak_score;
static PyObject *__pyx_n_s_peaks;
static PyObject *__pyx_n_s_pickle;
static PyObject *__pyx_n_s_pileup;
static PyObject *__pyx_n_u_pileup;
static PyObject *__pyx_n_s_pileup_a_chromosome;
static PyObject *__pyx_n_s_pileup_a_chromosome_c;
static PyObject *__pyx_n_s_poisson_cdf;
static PyObject *__pyx_n_s_pop;
static PyObject *__pyx_n_s_protocol;
static PyObject *__pyx_n_s_pscore;
static PyObject *__pyx_n_u_pscore;
static PyObject *__pyx_n_s_pscore_dict;
static PyObject *__pyx_kp_u_pscore_qscore_npeaks_lpeaks_avel;
static PyObject *__pyx_n_s_pseudocount;
static PyObject *__pyx_n_s_pyx_vtable;
static PyObject *__pyx_n_u_q;
static PyObject *__pyx_n_s_qscore;
static PyObject *__pyx_n_u_qscore;
static PyObject *__pyx_n_s_range;
static PyObject *__pyx_n_u_rb;
static PyObject *__pyx_n_s_rcond;
static PyObject *__pyx_n_s_reduce;
static PyObject *__pyx_n_s_reduce_cython;
static PyObject *__pyx_n_s_reduce_ex;
static PyObject *__pyx_n_s_refcheck;
static PyObject *__pyx_n_s_refine_peak_from_tags_distributi;
static PyObject *__pyx_n_s_resize;
static PyObject *__pyx_n_s_reverse;
static PyObject *__pyx_n_u_right;
static PyObject *__pyx_n_s_round;
static PyObject *__pyx_n_u_s;
static PyObject *__pyx_n_s_save_SPMR;
static PyObject *__pyx_n_s_save_bedGraph;
static PyObject *__pyx_n_s_score;
static PyObject *__pyx_n_u_score;
static PyObject *__pyx_n_s_score_cutoff_s;
static PyObject *__pyx_n_s_scoring_function_symbols;
static PyObject *__pyx_n_s_searchsorted;
static PyObject *__pyx_kp_s_self_bedGraph_ctrl_f_self_bedGra;
static PyObject *__pyx_n_s_set_pseudocount;
static PyObject *__pyx_n_s_setstate;
static PyObject *__pyx_n_s_setstate_cython;
static PyObject *__pyx_n_s_size;
static PyObject *__pyx_n_s_sort;
static PyObject *__pyx_n_s_sorted;
static PyObject *__pyx_n_s_sorted_2;
static PyObject *__pyx_n_u_start;
static PyObject *__pyx_n_s_stderr_on;
static PyObject *__pyx_n_s_sum;
static PyObject *__pyx_n_s_summit;
static PyObject *__pyx_n_u_summit;
static PyObject *__pyx_n_s_tempfile;
static PyObject *__pyx_n_s_test;
static PyObject *__pyx_n_s_thickEnd;
static PyObject *__pyx_n_s_thickStart;
static PyObject *__pyx_n_s_time;
static PyObject *__pyx_n_s_total;
static PyObject *__pyx_kp_u_track_type_bedGraph_name_control;
static PyObject *__pyx_kp_u_track_type_bedGraph_name_treatme;
static PyObject *__pyx_n_s_treat;
static PyObject *__pyx_kp_u_treat_pileup_bdg;
static PyObject *__pyx_n_s_treat_scaling_factor;
static PyObject *__pyx_n_s_ttime;
static PyObject *__pyx_kp_u_unknown_dtype_code_in_numpy_pxd;
static PyObject *__pyx_n_s_unlink;
static PyObject *__pyx_n_s_values;
static PyObject *__pyx_n_s_version;
static PyObject *__pyx_n_s_vstack;
static PyObject *__pyx_n_u_w;
static PyObject *__pyx_n_u_wb;
static PyObject *__pyx_n_s_window_size;
static PyObject *__pyx_n_s_write;
static PyObject *__pyx_n_s_zeros;
static PyObject *__pyx_n_s_zip;
static int __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_treat, PyObject *__pyx_v_ctrl, __pyx_t_5numpy_int32_t __pyx_v_d, PyObject *__pyx_v_ctrl_d_s, __pyx_t_5numpy_float32_t __pyx_v_treat_scaling_factor, PyObject *__pyx_v_ctrl_scaling_factor_s, CYTHON_UNUSED PyBoolObject *__pyx_v_stderr_on, __pyx_t_5numpy_float32_t __pyx_v_pseudocount, __pyx_t_5numpy_int32_t __pyx_v_end_shift, __pyx_t_5numpy_float32_t __pyx_v_lambda_bg, PyBoolObject *__pyx_v_save_bedGraph, PyObject *__pyx_v_bedGraph_filename_prefix, PyObject *__pyx_v_bedGraph_treat_filename, PyObject *__pyx_v_bedGraph_control_filename, PyObject *__pyx_v_cutoff_analysis_filename, PyBoolObject *__pyx_v_save_SPMR); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_2destroy(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_4set_pseudocount(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, __pyx_t_5numpy_float32_t __pyx_v_pseudocount); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_6enable_trackline(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_8call_peaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_score_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_max_gap, PyBoolObject *__pyx_v_call_summits, PyBoolObject *__pyx_v_cutoff_analysis); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_10call_broadpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_lvl1_cutoff_s, PyObject *__pyx_v_lvl2_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_lvl1_max_gap, __pyx_t_5numpy_int32_t __pyx_v_lvl2_max_gap, PyBoolObject *__pyx_v_cutoff_analysis); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_12refine_peak_from_tags_distribution(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_window_size, __pyx_t_5numpy_float32_t __pyx_v_cutoff); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_14__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self); /* proto */
static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_16__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state); /* proto */
static int __pyx_pf_5numpy_7ndarray___getbuffer__(PyArrayObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags); /* proto */
static void __pyx_pf_5numpy_7ndarray_2__releasebuffer__(PyArrayObject *__pyx_v_self, Py_buffer *__pyx_v_info); /* proto */
static PyObject *__pyx_tp_new_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments(PyTypeObject *t, PyObject *a, PyObject *k); /*proto*/
static __Pyx_CachedCFunction __pyx_umethod_PyDict_Type_get = {0, &__pyx_n_s_get, 0, 0, 0};
static __Pyx_CachedCFunction __pyx_umethod_PyDict_Type_keys = {0, &__pyx_n_s_keys, 0, 0, 0};
static __Pyx_CachedCFunction __pyx_umethod_PyDict_Type_pop = {0, &__pyx_n_s_pop, 0, 0, 0};
static __Pyx_CachedCFunction __pyx_umethod_PyDict_Type_values = {0, &__pyx_n_s_values, 0, 0, 0};
static __Pyx_CachedCFunction __pyx_umethod_PySet_Type_intersection = {0, &__pyx_n_s_intersection, 0, 0, 0};
static PyObject *__pyx_float_0_0;
static PyObject *__pyx_float_0_2;
static PyObject *__pyx_float_0_3;
static PyObject *__pyx_float_1_0;
static PyObject *__pyx_float_1e6;
static PyObject *__pyx_float_0_02;
static PyObject *__pyx_float_10_0;
static PyObject *__pyx_float_0_43429448190325176;
static PyObject *__pyx_float_neg_1_0;
static PyObject *__pyx_int_0;
static PyObject *__pyx_int_1;
static PyObject *__pyx_int_2;
static PyObject *__pyx_int_5;
static PyObject *__pyx_int_10;
static PyObject *__pyx_int_200;
static PyObject *__pyx_int_1000;
static PyObject *__pyx_int_10000;
static PyObject *__pyx_int_100000;
static PyObject *__pyx_int_neg_1;
static PyObject *__pyx_k__3;
static PyObject *__pyx_k__4;
static PyObject *__pyx_k__11;
static PyObject *__pyx_k__12;
static PyObject *__pyx_k__23;
static PyObject *__pyx_tuple_;
static PyObject *__pyx_slice__7;
static PyObject *__pyx_tuple__2;
static PyObject *__pyx_tuple__5;
static PyObject *__pyx_tuple__6;
static PyObject *__pyx_tuple__8;
static PyObject *__pyx_tuple__14;
static PyObject *__pyx_tuple__15;
static PyObject *__pyx_tuple__16;
static PyObject *__pyx_tuple__17;
static PyObject *__pyx_tuple__18;
static PyObject *__pyx_tuple__19;
static PyObject *__pyx_tuple__20;
static PyObject *__pyx_tuple__21;
static PyObject *__pyx_tuple__22;
/* Late includes */

/* "MACS2/IO/CallPeakUnit.pyx":58
 * 
 * #cdef float32_t get_pscore ( int32_t x, float32_t l ):
 * cdef float32_t get_pscore ( tuple x ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         float32_t val
 */

static __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_get_pscore(PyObject *__pyx_v_x) {
  __pyx_t_5numpy_float32_t __pyx_v_val;
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  int __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  __pyx_t_5numpy_float32_t __pyx_t_5;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  int __pyx_t_9;
  PyObject *__pyx_t_10 = NULL;
  __Pyx_RefNannySetupContext("get_pscore", 0);
  __Pyx_TraceCall("get_pscore", __pyx_f[0], 58, 0, __PYX_ERR(0, 58, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":61
 *     cdef:
 *         float32_t val
 *     if x in pscore_dict:             # <<<<<<<<<<<<<<
 *         return pscore_dict [ x ]
 *     else:
 */
  __Pyx_TraceLine(61,0,__PYX_ERR(0, 61, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_pscore_dict); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 61, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = (__Pyx_PySequence_ContainsTF(__pyx_v_x, __pyx_t_1, Py_EQ)); if (unlikely(__pyx_t_2 < 0)) __PYX_ERR(0, 61, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_3 = (__pyx_t_2 != 0);
  if (__pyx_t_3) {

    /* "MACS2/IO/CallPeakUnit.pyx":62
 *         float32_t val
 *     if x in pscore_dict:
 *         return pscore_dict [ x ]             # <<<<<<<<<<<<<<
 *     else:
 *         # calculate and cache
 */
    __Pyx_TraceLine(62,0,__PYX_ERR(0, 62, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_pscore_dict); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 62, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_4 = __Pyx_PyObject_GetItem(__pyx_t_1, __pyx_v_x); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 62, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_5 = __pyx_PyFloat_AsFloat(__pyx_t_4); if (unlikely((__pyx_t_5 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 62, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_r = __pyx_t_5;
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":61
 *     cdef:
 *         float32_t val
 *     if x in pscore_dict:             # <<<<<<<<<<<<<<
 *         return pscore_dict [ x ]
 *     else:
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":65
 *     else:
 *         # calculate and cache
 *         val = -1.0 * poisson_cdf ( x[0], x[1], False, True )             # <<<<<<<<<<<<<<
 *         pscore_dict[ x ] = val
 *         return val
 */
  __Pyx_TraceLine(65,0,__PYX_ERR(0, 65, __pyx_L1_error))
  /*else*/ {
    __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_poisson_cdf); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 65, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (unlikely(__pyx_v_x == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 65, __pyx_L1_error)
    }
    __pyx_t_6 = __Pyx_GetItemInt_Tuple(__pyx_v_x, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 65, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    if (unlikely(__pyx_v_x == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 65, __pyx_L1_error)
    }
    __pyx_t_7 = __Pyx_GetItemInt_Tuple(__pyx_v_x, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 65, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_8 = NULL;
    __pyx_t_9 = 0;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_1))) {
      __pyx_t_8 = PyMethod_GET_SELF(__pyx_t_1);
      if (likely(__pyx_t_8)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_1);
        __Pyx_INCREF(__pyx_t_8);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_1, function);
        __pyx_t_9 = 1;
      }
    }
    #if CYTHON_FAST_PYCALL
    if (PyFunction_Check(__pyx_t_1)) {
      PyObject *__pyx_temp[5] = {__pyx_t_8, __pyx_t_6, __pyx_t_7, Py_False, Py_True};
      __pyx_t_4 = __Pyx_PyFunction_FastCall(__pyx_t_1, __pyx_temp+1-__pyx_t_9, 4+__pyx_t_9); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 65, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    } else
    #endif
    #if CYTHON_FAST_PYCCALL
    if (__Pyx_PyFastCFunction_Check(__pyx_t_1)) {
      PyObject *__pyx_temp[5] = {__pyx_t_8, __pyx_t_6, __pyx_t_7, Py_False, Py_True};
      __pyx_t_4 = __Pyx_PyCFunction_FastCall(__pyx_t_1, __pyx_temp+1-__pyx_t_9, 4+__pyx_t_9); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 65, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    } else
    #endif
    {
      __pyx_t_10 = PyTuple_New(4+__pyx_t_9); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 65, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_10);
      if (__pyx_t_8) {
        __Pyx_GIVEREF(__pyx_t_8); PyTuple_SET_ITEM(__pyx_t_10, 0, __pyx_t_8); __pyx_t_8 = NULL;
      }
      __Pyx_GIVEREF(__pyx_t_6);
      PyTuple_SET_ITEM(__pyx_t_10, 0+__pyx_t_9, __pyx_t_6);
      __Pyx_GIVEREF(__pyx_t_7);
      PyTuple_SET_ITEM(__pyx_t_10, 1+__pyx_t_9, __pyx_t_7);
      __Pyx_INCREF(Py_False);
      __Pyx_GIVEREF(Py_False);
      PyTuple_SET_ITEM(__pyx_t_10, 2+__pyx_t_9, Py_False);
      __Pyx_INCREF(Py_True);
      __Pyx_GIVEREF(Py_True);
      PyTuple_SET_ITEM(__pyx_t_10, 3+__pyx_t_9, Py_True);
      __pyx_t_6 = 0;
      __pyx_t_7 = 0;
      __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_10, NULL); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 65, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
    }
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = PyNumber_Multiply(__pyx_float_neg_1_0, __pyx_t_4); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 65, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_5 = __pyx_PyFloat_AsFloat(__pyx_t_1); if (unlikely((__pyx_t_5 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 65, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_val = __pyx_t_5;

    /* "MACS2/IO/CallPeakUnit.pyx":66
 *         # calculate and cache
 *         val = -1.0 * poisson_cdf ( x[0], x[1], False, True )
 *         pscore_dict[ x ] = val             # <<<<<<<<<<<<<<
 *         return val
 * 
 */
    __Pyx_TraceLine(66,0,__PYX_ERR(0, 66, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_val); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 66, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_pscore_dict); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 66, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    if (unlikely(PyObject_SetItem(__pyx_t_4, __pyx_v_x, __pyx_t_1) < 0)) __PYX_ERR(0, 66, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":67
 *         val = -1.0 * poisson_cdf ( x[0], x[1], False, True )
 *         pscore_dict[ x ] = val
 *         return val             # <<<<<<<<<<<<<<
 * 
 * cdef float32_t get_logLR_asym ( float32_t x, float32_t y ):
 */
    __Pyx_TraceLine(67,0,__PYX_ERR(0, 67, __pyx_L1_error))
    __pyx_r = __pyx_v_val;
    goto __pyx_L0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":58
 * 
 * #cdef float32_t get_pscore ( int32_t x, float32_t l ):
 * cdef float32_t get_pscore ( tuple x ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         float32_t val
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_XDECREF(__pyx_t_10);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.get_pscore", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":69
 *         return val
 * 
 * cdef float32_t get_logLR_asym ( float32_t x, float32_t y ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         float32_t val
 */

static __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_get_logLR_asym(__pyx_t_5numpy_float32_t __pyx_v_x, __pyx_t_5numpy_float32_t __pyx_v_y) {
  __pyx_t_5numpy_float32_t __pyx_v_val;
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_t_5;
  PyObject *__pyx_t_6 = NULL;
  __pyx_t_5numpy_float32_t __pyx_t_7;
  PyObject *__pyx_t_8 = NULL;
  __Pyx_RefNannySetupContext("get_logLR_asym", 0);
  __Pyx_TraceCall("get_logLR_asym", __pyx_f[0], 69, 0, __PYX_ERR(0, 69, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":73
 *         float32_t val
 * 
 *     if ( x, y ) in logLR_dict:             # <<<<<<<<<<<<<<
 *         return logLR_dict[ ( x, y ) ]
 *     else:
 */
  __Pyx_TraceLine(73,0,__PYX_ERR(0, 73, __pyx_L1_error))
  __pyx_t_1 = PyFloat_FromDouble(__pyx_v_x); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 73, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = PyFloat_FromDouble(__pyx_v_y); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 73, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 73, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_2);
  __pyx_t_1 = 0;
  __pyx_t_2 = 0;
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logLR_dict); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 73, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_4 = (__Pyx_PySequence_ContainsTF(__pyx_t_3, __pyx_t_2, Py_EQ)); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 73, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_5 = (__pyx_t_4 != 0);
  if (__pyx_t_5) {

    /* "MACS2/IO/CallPeakUnit.pyx":74
 * 
 *     if ( x, y ) in logLR_dict:
 *         return logLR_dict[ ( x, y ) ]             # <<<<<<<<<<<<<<
 *     else:
 *         # calculate and cache
 */
    __Pyx_TraceLine(74,0,__PYX_ERR(0, 74, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logLR_dict); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 74, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = PyFloat_FromDouble(__pyx_v_x); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 74, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_y); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 74, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_6 = PyTuple_New(2); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 74, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_GIVEREF(__pyx_t_3);
    PyTuple_SET_ITEM(__pyx_t_6, 0, __pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_1);
    PyTuple_SET_ITEM(__pyx_t_6, 1, __pyx_t_1);
    __pyx_t_3 = 0;
    __pyx_t_1 = 0;
    __pyx_t_1 = __Pyx_PyObject_GetItem(__pyx_t_2, __pyx_t_6); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 74, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __pyx_t_7 = __pyx_PyFloat_AsFloat(__pyx_t_1); if (unlikely((__pyx_t_7 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 74, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_r = __pyx_t_7;
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":73
 *         float32_t val
 * 
 *     if ( x, y ) in logLR_dict:             # <<<<<<<<<<<<<<
 *         return logLR_dict[ ( x, y ) ]
 *     else:
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":77
 *     else:
 *         # calculate and cache
 *         if x > y:             # <<<<<<<<<<<<<<
 *             val = (x*(log10(x)-log10(y))+y-x)
 *         elif x < y:
 */
  __Pyx_TraceLine(77,0,__PYX_ERR(0, 77, __pyx_L1_error))
  /*else*/ {
    __pyx_t_5 = ((__pyx_v_x > __pyx_v_y) != 0);
    if (__pyx_t_5) {

      /* "MACS2/IO/CallPeakUnit.pyx":78
 *         # calculate and cache
 *         if x > y:
 *             val = (x*(log10(x)-log10(y))+y-x)             # <<<<<<<<<<<<<<
 *         elif x < y:
 *             val = (x*(-log10(x)+log10(y))-y+x)
 */
      __Pyx_TraceLine(78,0,__PYX_ERR(0, 78, __pyx_L1_error))
      __pyx_v_val = (((__pyx_v_x * (log10(__pyx_v_x) - log10(__pyx_v_y))) + __pyx_v_y) - __pyx_v_x);

      /* "MACS2/IO/CallPeakUnit.pyx":77
 *     else:
 *         # calculate and cache
 *         if x > y:             # <<<<<<<<<<<<<<
 *             val = (x*(log10(x)-log10(y))+y-x)
 *         elif x < y:
 */
      goto __pyx_L4;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":79
 *         if x > y:
 *             val = (x*(log10(x)-log10(y))+y-x)
 *         elif x < y:             # <<<<<<<<<<<<<<
 *             val = (x*(-log10(x)+log10(y))-y+x)
 *         else:
 */
    __Pyx_TraceLine(79,0,__PYX_ERR(0, 79, __pyx_L1_error))
    __pyx_t_5 = ((__pyx_v_x < __pyx_v_y) != 0);
    if (__pyx_t_5) {

      /* "MACS2/IO/CallPeakUnit.pyx":80
 *             val = (x*(log10(x)-log10(y))+y-x)
 *         elif x < y:
 *             val = (x*(-log10(x)+log10(y))-y+x)             # <<<<<<<<<<<<<<
 *         else:
 *             val = 0
 */
      __Pyx_TraceLine(80,0,__PYX_ERR(0, 80, __pyx_L1_error))
      __pyx_v_val = (((__pyx_v_x * ((-log10(__pyx_v_x)) + log10(__pyx_v_y))) - __pyx_v_y) + __pyx_v_x);

      /* "MACS2/IO/CallPeakUnit.pyx":79
 *         if x > y:
 *             val = (x*(log10(x)-log10(y))+y-x)
 *         elif x < y:             # <<<<<<<<<<<<<<
 *             val = (x*(-log10(x)+log10(y))-y+x)
 *         else:
 */
      goto __pyx_L4;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":82
 *             val = (x*(-log10(x)+log10(y))-y+x)
 *         else:
 *             val = 0             # <<<<<<<<<<<<<<
 *         logLR_dict[ ( x, y ) ] = val
 *         return val
 */
    __Pyx_TraceLine(82,0,__PYX_ERR(0, 82, __pyx_L1_error))
    /*else*/ {
      __pyx_v_val = 0.0;
    }
    __pyx_L4:;

    /* "MACS2/IO/CallPeakUnit.pyx":83
 *         else:
 *             val = 0
 *         logLR_dict[ ( x, y ) ] = val             # <<<<<<<<<<<<<<
 *         return val
 * 
 */
    __Pyx_TraceLine(83,0,__PYX_ERR(0, 83, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_val); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 83, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_logLR_dict); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 83, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_2 = PyFloat_FromDouble(__pyx_v_x); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 83, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = PyFloat_FromDouble(__pyx_v_y); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 83, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_8 = PyTuple_New(2); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 83, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_GIVEREF(__pyx_t_2);
    PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_t_2);
    __Pyx_GIVEREF(__pyx_t_3);
    PyTuple_SET_ITEM(__pyx_t_8, 1, __pyx_t_3);
    __pyx_t_2 = 0;
    __pyx_t_3 = 0;
    if (unlikely(PyObject_SetItem(__pyx_t_6, __pyx_t_8, __pyx_t_1) < 0)) __PYX_ERR(0, 83, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":84
 *             val = 0
 *         logLR_dict[ ( x, y ) ] = val
 *         return val             # <<<<<<<<<<<<<<
 * 
 * # ------------------------------------
 */
    __Pyx_TraceLine(84,0,__PYX_ERR(0, 84, __pyx_L1_error))
    __pyx_r = __pyx_v_val;
    goto __pyx_L0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":69
 *         return val
 * 
 * cdef float32_t get_logLR_asym ( float32_t x, float32_t y ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         float32_t val
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.get_logLR_asym", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":98
 * LOG10_E = 0.43429448190325176
 * 
 * cdef void clean_up_ndarray ( np.ndarray x ):             # <<<<<<<<<<<<<<
 *     # clean numpy ndarray in two steps
 *     cdef:
 */

static void __pyx_f_5MACS2_2IO_12CallPeakUnit_clean_up_ndarray(PyArrayObject *__pyx_v_x) {
  __pyx_t_5numpy_int64_t __pyx_v_i;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  __Pyx_RefNannySetupContext("clean_up_ndarray", 0);
  __Pyx_TraceCall("clean_up_ndarray", __pyx_f[0], 98, 0, __PYX_ERR(0, 98, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":102
 *     cdef:
 *         int64_t i
 *     i = x.shape[0] // 2             # <<<<<<<<<<<<<<
 *     x.resize( 100000 if i > 100000 else i, refcheck=False)
 *     x.resize( 0, refcheck=False)
 */
  __Pyx_TraceLine(102,0,__PYX_ERR(0, 102, __pyx_L1_error))
  __pyx_v_i = __Pyx_div_long((__pyx_v_x->dimensions[0]), 2);

  /* "MACS2/IO/CallPeakUnit.pyx":103
 *         int64_t i
 *     i = x.shape[0] // 2
 *     x.resize( 100000 if i > 100000 else i, refcheck=False)             # <<<<<<<<<<<<<<
 *     x.resize( 0, refcheck=False)
 *     return
 */
  __Pyx_TraceLine(103,0,__PYX_ERR(0, 103, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_x), __pyx_n_s_resize); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 103, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (((__pyx_v_i > 0x186A0) != 0)) {
    __Pyx_INCREF(__pyx_int_100000);
    __pyx_t_2 = __pyx_int_100000;
  } else {
    __pyx_t_3 = __Pyx_PyInt_From_npy_int64(__pyx_v_i); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 103, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_2 = __pyx_t_3;
    __pyx_t_3 = 0;
  }
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 103, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 103, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_refcheck, Py_False) < 0) __PYX_ERR(0, 103, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 103, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":104
 *     i = x.shape[0] // 2
 *     x.resize( 100000 if i > 100000 else i, refcheck=False)
 *     x.resize( 0, refcheck=False)             # <<<<<<<<<<<<<<
 *     return
 * 
 */
  __Pyx_TraceLine(104,0,__PYX_ERR(0, 104, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_x), __pyx_n_s_resize); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 104, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 104, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_refcheck, Py_False) < 0) __PYX_ERR(0, 104, __pyx_L1_error)
  __pyx_t_3 = __Pyx_PyObject_Call(__pyx_t_4, __pyx_tuple_, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 104, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":105
 *     x.resize( 100000 if i > 100000 else i, refcheck=False)
 *     x.resize( 0, refcheck=False)
 *     return             # <<<<<<<<<<<<<<
 * 
 * cdef inline float32_t chi2_k1_cdf ( float32_t x ):
 */
  __Pyx_TraceLine(105,0,__PYX_ERR(0, 105, __pyx_L1_error))
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":98
 * LOG10_E = 0.43429448190325176
 * 
 * cdef void clean_up_ndarray ( np.ndarray x ):             # <<<<<<<<<<<<<<
 *     # clean numpy ndarray in two steps
 *     cdef:
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.clean_up_ndarray", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "MACS2/IO/CallPeakUnit.pyx":107
 *     return
 * 
 * cdef inline float32_t chi2_k1_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *     return erf( sqrt(x/2) )
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_chi2_k1_cdf(__pyx_t_5numpy_float32_t __pyx_v_x) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("chi2_k1_cdf", 0);
  __Pyx_TraceCall("chi2_k1_cdf", __pyx_f[0], 107, 0, __PYX_ERR(0, 107, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":108
 * 
 * cdef inline float32_t chi2_k1_cdf ( float32_t x ):
 *     return erf( sqrt(x/2) )             # <<<<<<<<<<<<<<
 * 
 * cdef inline float32_t log10_chi2_k1_cdf ( float32_t x ):
 */
  __Pyx_TraceLine(108,0,__PYX_ERR(0, 108, __pyx_L1_error))
  __pyx_r = erf(sqrt((__pyx_v_x / 2.0)));
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":107
 *     return
 * 
 * cdef inline float32_t chi2_k1_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *     return erf( sqrt(x/2) )
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.chi2_k1_cdf", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":110
 *     return erf( sqrt(x/2) )
 * 
 * cdef inline float32_t log10_chi2_k1_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log10( erf( sqrt(x/2) ) )
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_log10_chi2_k1_cdf(__pyx_t_5numpy_float32_t __pyx_v_x) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("log10_chi2_k1_cdf", 0);
  __Pyx_TraceCall("log10_chi2_k1_cdf", __pyx_f[0], 110, 0, __PYX_ERR(0, 110, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":111
 * 
 * cdef inline float32_t log10_chi2_k1_cdf ( float32_t x ):
 *   return log10( erf( sqrt(x/2) ) )             # <<<<<<<<<<<<<<
 * 
 * cdef inline float32_t chi2_k2_cdf ( float32_t x ):
 */
  __Pyx_TraceLine(111,0,__PYX_ERR(0, 111, __pyx_L1_error))
  __pyx_r = log10(erf(sqrt((__pyx_v_x / 2.0))));
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":110
 *     return erf( sqrt(x/2) )
 * 
 * cdef inline float32_t log10_chi2_k1_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log10( erf( sqrt(x/2) ) )
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.log10_chi2_k1_cdf", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":113
 *   return log10( erf( sqrt(x/2) ) )
 * 
 * cdef inline float32_t chi2_k2_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return 1 - exp( -x/2 )
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_chi2_k2_cdf(__pyx_t_5numpy_float32_t __pyx_v_x) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("chi2_k2_cdf", 0);
  __Pyx_TraceCall("chi2_k2_cdf", __pyx_f[0], 113, 0, __PYX_ERR(0, 113, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":114
 * 
 * cdef inline float32_t chi2_k2_cdf ( float32_t x ):
 *   return 1 - exp( -x/2 )             # <<<<<<<<<<<<<<
 * 
 * cdef inline float32_t log10_chi2_k2_cdf ( float32_t x ):
 */
  __Pyx_TraceLine(114,0,__PYX_ERR(0, 114, __pyx_L1_error))
  __pyx_r = (1.0 - exp(((-__pyx_v_x) / 2.0)));
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":113
 *   return log10( erf( sqrt(x/2) ) )
 * 
 * cdef inline float32_t chi2_k2_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return 1 - exp( -x/2 )
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.chi2_k2_cdf", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":116
 *   return 1 - exp( -x/2 )
 * 
 * cdef inline float32_t log10_chi2_k2_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log1p( - exp( -x/2 ) ) * LOG10_E
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_log10_chi2_k2_cdf(__pyx_t_5numpy_float32_t __pyx_v_x) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  __pyx_t_5numpy_float32_t __pyx_t_4;
  __Pyx_RefNannySetupContext("log10_chi2_k2_cdf", 0);
  __Pyx_TraceCall("log10_chi2_k2_cdf", __pyx_f[0], 116, 0, __PYX_ERR(0, 116, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":117
 * 
 * cdef inline float32_t log10_chi2_k2_cdf ( float32_t x ):
 *   return log1p( - exp( -x/2 ) ) * LOG10_E             # <<<<<<<<<<<<<<
 * 
 * cdef inline float32_t chi2_k4_cdf ( float32_t x ):
 */
  __Pyx_TraceLine(117,0,__PYX_ERR(0, 117, __pyx_L1_error))
  __pyx_t_1 = PyFloat_FromDouble(log1p((-exp(((-__pyx_v_x) / 2.0))))); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 117, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_LOG10_E); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 117, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyNumber_Multiply(__pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 117, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_4 = __pyx_PyFloat_AsFloat(__pyx_t_3); if (unlikely((__pyx_t_4 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 117, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_r = __pyx_t_4;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":116
 *   return 1 - exp( -x/2 )
 * 
 * cdef inline float32_t log10_chi2_k2_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log1p( - exp( -x/2 ) ) * LOG10_E
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.log10_chi2_k2_cdf", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":119
 *   return log1p( - exp( -x/2 ) ) * LOG10_E
 * 
 * cdef inline float32_t chi2_k4_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return 1 - exp( -x/2 ) * ( 1 + x/2 )
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_chi2_k4_cdf(__pyx_t_5numpy_float32_t __pyx_v_x) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("chi2_k4_cdf", 0);
  __Pyx_TraceCall("chi2_k4_cdf", __pyx_f[0], 119, 0, __PYX_ERR(0, 119, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":120
 * 
 * cdef inline float32_t chi2_k4_cdf ( float32_t x ):
 *   return 1 - exp( -x/2 ) * ( 1 + x/2 )             # <<<<<<<<<<<<<<
 * 
 * cdef inline float32_t log10_chi2_k4_CDF ( float32_t x ):
 */
  __Pyx_TraceLine(120,0,__PYX_ERR(0, 120, __pyx_L1_error))
  __pyx_r = (1.0 - (exp(((-__pyx_v_x) / 2.0)) * (1.0 + (__pyx_v_x / 2.0))));
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":119
 *   return log1p( - exp( -x/2 ) ) * LOG10_E
 * 
 * cdef inline float32_t chi2_k4_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return 1 - exp( -x/2 ) * ( 1 + x/2 )
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.chi2_k4_cdf", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":122
 *   return 1 - exp( -x/2 ) * ( 1 + x/2 )
 * 
 * cdef inline float32_t log10_chi2_k4_CDF ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log1p( - exp( -x/2 ) * ( 1 + x/2 ) ) * LOG10_E
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_log10_chi2_k4_CDF(__pyx_t_5numpy_float32_t __pyx_v_x) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  __pyx_t_5numpy_float32_t __pyx_t_4;
  __Pyx_RefNannySetupContext("log10_chi2_k4_CDF", 0);
  __Pyx_TraceCall("log10_chi2_k4_CDF", __pyx_f[0], 122, 0, __PYX_ERR(0, 122, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":123
 * 
 * cdef inline float32_t log10_chi2_k4_CDF ( float32_t x ):
 *   return log1p( - exp( -x/2 ) * ( 1 + x/2 ) ) * LOG10_E             # <<<<<<<<<<<<<<
 * 
 * cdef inline np.ndarray apply_multiple_cutoffs ( list multiple_score_arrays, list multiple_cutoffs ):
 */
  __Pyx_TraceLine(123,0,__PYX_ERR(0, 123, __pyx_L1_error))
  __pyx_t_1 = PyFloat_FromDouble(log1p(((-exp(((-__pyx_v_x) / 2.0))) * (1.0 + (__pyx_v_x / 2.0))))); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 123, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_LOG10_E); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 123, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyNumber_Multiply(__pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 123, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_4 = __pyx_PyFloat_AsFloat(__pyx_t_3); if (unlikely((__pyx_t_4 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 123, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_r = __pyx_t_4;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":122
 *   return 1 - exp( -x/2 ) * ( 1 + x/2 )
 * 
 * cdef inline float32_t log10_chi2_k4_CDF ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log1p( - exp( -x/2 ) * ( 1 + x/2 ) ) * LOG10_E
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.log10_chi2_k4_CDF", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":125
 *   return log1p( - exp( -x/2 ) * ( 1 + x/2 ) ) * LOG10_E
 * 
 * cdef inline np.ndarray apply_multiple_cutoffs ( list multiple_score_arrays, list multiple_cutoffs ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         int32_t i
 */

static CYTHON_INLINE PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_apply_multiple_cutoffs(PyObject *__pyx_v_multiple_score_arrays, PyObject *__pyx_v_multiple_cutoffs) {
  __pyx_t_5numpy_int32_t __pyx_v_i;
  PyArrayObject *__pyx_v_ret = 0;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  Py_ssize_t __pyx_t_4;
  Py_ssize_t __pyx_t_5;
  __pyx_t_5numpy_int32_t __pyx_t_6;
  __Pyx_RefNannySetupContext("apply_multiple_cutoffs", 0);
  __Pyx_TraceCall("apply_multiple_cutoffs", __pyx_f[0], 125, 0, __PYX_ERR(0, 125, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":130
 *         np.ndarray ret
 * 
 *     ret = multiple_score_arrays[0] > multiple_cutoffs[0]             # <<<<<<<<<<<<<<
 * 
 *     for i in range(1,len(multiple_score_arrays)):
 */
  __Pyx_TraceLine(130,0,__PYX_ERR(0, 130, __pyx_L1_error))
  if (unlikely(__pyx_v_multiple_score_arrays == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 130, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_multiple_score_arrays, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 130, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (unlikely(__pyx_v_multiple_cutoffs == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 130, __pyx_L1_error)
  }
  __pyx_t_2 = __Pyx_GetItemInt_List(__pyx_v_multiple_cutoffs, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 130, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyObject_RichCompare(__pyx_t_1, __pyx_t_2, Py_GT); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 130, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 130, __pyx_L1_error)
  __pyx_v_ret = ((PyArrayObject *)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":132
 *     ret = multiple_score_arrays[0] > multiple_cutoffs[0]
 * 
 *     for i in range(1,len(multiple_score_arrays)):             # <<<<<<<<<<<<<<
 *         ret += multiple_score_arrays[i] > multiple_cutoffs[i]
 * 
 */
  __Pyx_TraceLine(132,0,__PYX_ERR(0, 132, __pyx_L1_error))
  if (unlikely(__pyx_v_multiple_score_arrays == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 132, __pyx_L1_error)
  }
  __pyx_t_4 = PyList_GET_SIZE(__pyx_v_multiple_score_arrays); if (unlikely(__pyx_t_4 == ((Py_ssize_t)-1))) __PYX_ERR(0, 132, __pyx_L1_error)
  __pyx_t_5 = __pyx_t_4;
  for (__pyx_t_6 = 1; __pyx_t_6 < __pyx_t_5; __pyx_t_6+=1) {
    __pyx_v_i = __pyx_t_6;

    /* "MACS2/IO/CallPeakUnit.pyx":133
 * 
 *     for i in range(1,len(multiple_score_arrays)):
 *         ret += multiple_score_arrays[i] > multiple_cutoffs[i]             # <<<<<<<<<<<<<<
 * 
 *     return ret
 */
    __Pyx_TraceLine(133,0,__PYX_ERR(0, 133, __pyx_L1_error))
    if (unlikely(__pyx_v_multiple_score_arrays == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 133, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_multiple_score_arrays, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 133, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    if (unlikely(__pyx_v_multiple_cutoffs == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 133, __pyx_L1_error)
    }
    __pyx_t_2 = __Pyx_GetItemInt_List(__pyx_v_multiple_cutoffs, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 133, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_1 = PyObject_RichCompare(__pyx_t_3, __pyx_t_2, Py_GT); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 133, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = PyNumber_InPlaceAdd(((PyObject *)__pyx_v_ret), __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 133, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 133, __pyx_L1_error)
    __Pyx_DECREF_SET(__pyx_v_ret, ((PyArrayObject *)__pyx_t_2));
    __pyx_t_2 = 0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":135
 *         ret += multiple_score_arrays[i] > multiple_cutoffs[i]
 * 
 *     return ret             # <<<<<<<<<<<<<<
 * 
 * cdef inline list get_from_multiple_scores ( list multiple_score_arrays, int32_t index ):
 */
  __Pyx_TraceLine(135,0,__PYX_ERR(0, 135, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_ret));
  __pyx_r = __pyx_v_ret;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":125
 *   return log1p( - exp( -x/2 ) * ( 1 + x/2 ) ) * LOG10_E
 * 
 * cdef inline np.ndarray apply_multiple_cutoffs ( list multiple_score_arrays, list multiple_cutoffs ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         int32_t i
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.apply_multiple_cutoffs", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_ret);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":137
 *     return ret
 * 
 * cdef inline list get_from_multiple_scores ( list multiple_score_arrays, int32_t index ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         list ret = []
 */

static CYTHON_INLINE PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_get_from_multiple_scores(PyObject *__pyx_v_multiple_score_arrays, __pyx_t_5numpy_int32_t __pyx_v_index) {
  PyObject *__pyx_v_ret = 0;
  __pyx_t_5numpy_int32_t __pyx_v_i;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  Py_ssize_t __pyx_t_2;
  Py_ssize_t __pyx_t_3;
  __pyx_t_5numpy_int32_t __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  __Pyx_RefNannySetupContext("get_from_multiple_scores", 0);
  __Pyx_TraceCall("get_from_multiple_scores", __pyx_f[0], 137, 0, __PYX_ERR(0, 137, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":139
 * cdef inline list get_from_multiple_scores ( list multiple_score_arrays, int32_t index ):
 *     cdef:
 *         list ret = []             # <<<<<<<<<<<<<<
 *         int32_t i
 * 
 */
  __Pyx_TraceLine(139,0,__PYX_ERR(0, 139, __pyx_L1_error))
  __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 139, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_ret = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":142
 *         int32_t i
 * 
 *     for i in range(len(multiple_score_arrays)):             # <<<<<<<<<<<<<<
 *         ret.append(multiple_score_arrays[i][index])
 *     return ret
 */
  __Pyx_TraceLine(142,0,__PYX_ERR(0, 142, __pyx_L1_error))
  if (unlikely(__pyx_v_multiple_score_arrays == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 142, __pyx_L1_error)
  }
  __pyx_t_2 = PyList_GET_SIZE(__pyx_v_multiple_score_arrays); if (unlikely(__pyx_t_2 == ((Py_ssize_t)-1))) __PYX_ERR(0, 142, __pyx_L1_error)
  __pyx_t_3 = __pyx_t_2;
  for (__pyx_t_4 = 0; __pyx_t_4 < __pyx_t_3; __pyx_t_4+=1) {
    __pyx_v_i = __pyx_t_4;

    /* "MACS2/IO/CallPeakUnit.pyx":143
 * 
 *     for i in range(len(multiple_score_arrays)):
 *         ret.append(multiple_score_arrays[i][index])             # <<<<<<<<<<<<<<
 *     return ret
 * 
 */
    __Pyx_TraceLine(143,0,__PYX_ERR(0, 143, __pyx_L1_error))
    if (unlikely(__pyx_v_multiple_score_arrays == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 143, __pyx_L1_error)
    }
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_multiple_score_arrays, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 143, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_5 = __Pyx_GetItemInt(__pyx_t_1, __pyx_v_index, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 143, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_6 = __Pyx_PyList_Append(__pyx_v_ret, __pyx_t_5); if (unlikely(__pyx_t_6 == ((int)-1))) __PYX_ERR(0, 143, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":144
 *     for i in range(len(multiple_score_arrays)):
 *         ret.append(multiple_score_arrays[i][index])
 *     return ret             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_TraceLine(144,0,__PYX_ERR(0, 144, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_ret);
  __pyx_r = __pyx_v_ret;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":137
 *     return ret
 * 
 * cdef inline list get_from_multiple_scores ( list multiple_score_arrays, int32_t index ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         list ret = []
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.get_from_multiple_scores", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_ret);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":147
 * 
 * 
 * cdef inline float32_t get_logFE ( float32_t x, float32_t y ):             # <<<<<<<<<<<<<<
 *     """ return 100* log10 fold enrichment with +1 pseudocount.
 *     """
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_get_logFE(__pyx_t_5numpy_float32_t __pyx_v_x, __pyx_t_5numpy_float32_t __pyx_v_y) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("get_logFE", 0);
  __Pyx_TraceCall("get_logFE", __pyx_f[0], 147, 0, __PYX_ERR(0, 147, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":150
 *     """ return 100* log10 fold enrichment with +1 pseudocount.
 *     """
 *     return log10( x/y )             # <<<<<<<<<<<<<<
 * 
 * cdef inline float32_t get_subtraction ( float32_t x, float32_t y):
 */
  __Pyx_TraceLine(150,0,__PYX_ERR(0, 150, __pyx_L1_error))
  if (unlikely(__pyx_v_y == 0)) {
    PyErr_SetString(PyExc_ZeroDivisionError, "float division");
    __PYX_ERR(0, 150, __pyx_L1_error)
  }
  __pyx_r = log10((__pyx_v_x / __pyx_v_y));
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":147
 * 
 * 
 * cdef inline float32_t get_logFE ( float32_t x, float32_t y ):             # <<<<<<<<<<<<<<
 *     """ return 100* log10 fold enrichment with +1 pseudocount.
 *     """
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.get_logFE", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":152
 *     return log10( x/y )
 * 
 * cdef inline float32_t get_subtraction ( float32_t x, float32_t y):             # <<<<<<<<<<<<<<
 *     """ return subtraction.
 *     """
 */

static CYTHON_INLINE __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_get_subtraction(__pyx_t_5numpy_float32_t __pyx_v_x, __pyx_t_5numpy_float32_t __pyx_v_y) {
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("get_subtraction", 0);
  __Pyx_TraceCall("get_subtraction", __pyx_f[0], 152, 0, __PYX_ERR(0, 152, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":155
 *     """ return subtraction.
 *     """
 *     return x - y             # <<<<<<<<<<<<<<
 * 
 * cdef inline list getitem_then_subtract ( list peakset, int32_t start ):
 */
  __Pyx_TraceLine(155,0,__PYX_ERR(0, 155, __pyx_L1_error))
  __pyx_r = (__pyx_v_x - __pyx_v_y);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":152
 *     return log10( x/y )
 * 
 * cdef inline float32_t get_subtraction ( float32_t x, float32_t y):             # <<<<<<<<<<<<<<
 *     """ return subtraction.
 *     """
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.get_subtraction", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":157
 *     return x - y
 * 
 * cdef inline list getitem_then_subtract ( list peakset, int32_t start ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         list a
 */

static CYTHON_INLINE PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_getitem_then_subtract(PyObject *__pyx_v_peakset, __pyx_t_5numpy_int32_t __pyx_v_start) {
  PyObject *__pyx_v_a = 0;
  Py_ssize_t __pyx_v_i;
  PyObject *__pyx_7genexpr__pyx_v_x = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  Py_ssize_t __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  Py_ssize_t __pyx_t_5;
  Py_ssize_t __pyx_t_6;
  __Pyx_RefNannySetupContext("getitem_then_subtract", 0);
  __Pyx_TraceCall("getitem_then_subtract", __pyx_f[0], 157, 0, __PYX_ERR(0, 157, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":161
 *         list a
 * 
 *     a = [x["start"] for x in peakset]             # <<<<<<<<<<<<<<
 *     for i in range(len(a)):
 *         a[i] = a[i] - start
 */
  __Pyx_TraceLine(161,0,__PYX_ERR(0, 161, __pyx_L1_error))
  { /* enter inner scope */
    __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 161, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (unlikely(__pyx_v_peakset == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
      __PYX_ERR(0, 161, __pyx_L5_error)
    }
    __pyx_t_2 = __pyx_v_peakset; __Pyx_INCREF(__pyx_t_2); __pyx_t_3 = 0;
    for (;;) {
      if (__pyx_t_3 >= PyList_GET_SIZE(__pyx_t_2)) break;
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      __pyx_t_4 = PyList_GET_ITEM(__pyx_t_2, __pyx_t_3); __Pyx_INCREF(__pyx_t_4); __pyx_t_3++; if (unlikely(0 < 0)) __PYX_ERR(0, 161, __pyx_L5_error)
      #else
      __pyx_t_4 = PySequence_ITEM(__pyx_t_2, __pyx_t_3); __pyx_t_3++; if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 161, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_4);
      #endif
      __Pyx_XDECREF_SET(__pyx_7genexpr__pyx_v_x, __pyx_t_4);
      __pyx_t_4 = 0;
      __pyx_t_4 = __Pyx_PyObject_Dict_GetItem(__pyx_7genexpr__pyx_v_x, __pyx_n_u_start); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 161, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_4);
      if (unlikely(__Pyx_ListComp_Append(__pyx_t_1, (PyObject*)__pyx_t_4))) __PYX_ERR(0, 161, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    }
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_7genexpr__pyx_v_x); __pyx_7genexpr__pyx_v_x = 0;
    goto __pyx_L8_exit_scope;
    __pyx_L5_error:;
    __Pyx_XDECREF(__pyx_7genexpr__pyx_v_x); __pyx_7genexpr__pyx_v_x = 0;
    goto __pyx_L1_error;
    __pyx_L8_exit_scope:;
  } /* exit inner scope */
  __pyx_v_a = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":162
 * 
 *     a = [x["start"] for x in peakset]
 *     for i in range(len(a)):             # <<<<<<<<<<<<<<
 *         a[i] = a[i] - start
 *     return a
 */
  __Pyx_TraceLine(162,0,__PYX_ERR(0, 162, __pyx_L1_error))
  __pyx_t_3 = PyList_GET_SIZE(__pyx_v_a); if (unlikely(__pyx_t_3 == ((Py_ssize_t)-1))) __PYX_ERR(0, 162, __pyx_L1_error)
  __pyx_t_5 = __pyx_t_3;
  for (__pyx_t_6 = 0; __pyx_t_6 < __pyx_t_5; __pyx_t_6+=1) {
    __pyx_v_i = __pyx_t_6;

    /* "MACS2/IO/CallPeakUnit.pyx":163
 *     a = [x["start"] for x in peakset]
 *     for i in range(len(a)):
 *         a[i] = a[i] - start             # <<<<<<<<<<<<<<
 *     return a
 * 
 */
    __Pyx_TraceLine(163,0,__PYX_ERR(0, 163, __pyx_L1_error))
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_a, __pyx_v_i, Py_ssize_t, 1, PyInt_FromSsize_t, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 163, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_2 = __Pyx_PyInt_From_npy_int32(__pyx_v_start); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 163, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_4 = PyNumber_Subtract(__pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 163, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(__Pyx_SetItemInt(__pyx_v_a, __pyx_v_i, __pyx_t_4, Py_ssize_t, 1, PyInt_FromSsize_t, 1, 1, 1) < 0)) __PYX_ERR(0, 163, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":164
 *     for i in range(len(a)):
 *         a[i] = a[i] - start
 *     return a             # <<<<<<<<<<<<<<
 * 
 * cdef inline int32_t left_sum ( data, int32_t pos, int32_t width ):
 */
  __Pyx_TraceLine(164,0,__PYX_ERR(0, 164, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_a);
  __pyx_r = __pyx_v_a;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":157
 *     return x - y
 * 
 * cdef inline list getitem_then_subtract ( list peakset, int32_t start ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         list a
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.getitem_then_subtract", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_a);
  __Pyx_XDECREF(__pyx_7genexpr__pyx_v_x);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":166
 *     return a
 * 
 * cdef inline int32_t left_sum ( data, int32_t pos, int32_t width ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */

static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_left_sum(PyObject *__pyx_v_data, __pyx_t_5numpy_int32_t __pyx_v_pos, __pyx_t_5numpy_int32_t __pyx_v_width) {
  PyObject *__pyx_8genexpr1__pyx_v_x = NULL;
  __pyx_t_5numpy_int32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  Py_ssize_t __pyx_t_3;
  PyObject *(*__pyx_t_4)(PyObject *);
  PyObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  __pyx_t_5numpy_int32_t __pyx_t_9;
  __Pyx_RefNannySetupContext("left_sum", 0);
  __Pyx_TraceCall("left_sum", __pyx_f[0], 166, 0, __PYX_ERR(0, 166, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":169
 *     """
 *     """
 *     return sum([data[x] for x in data if x <= pos and x >= pos - width])             # <<<<<<<<<<<<<<
 * 
 * cdef inline int32_t right_sum ( data, int32_t pos, int32_t width ):
 */
  __Pyx_TraceLine(169,0,__PYX_ERR(0, 169, __pyx_L1_error))
  { /* enter inner scope */
    __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 169, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (likely(PyList_CheckExact(__pyx_v_data)) || PyTuple_CheckExact(__pyx_v_data)) {
      __pyx_t_2 = __pyx_v_data; __Pyx_INCREF(__pyx_t_2); __pyx_t_3 = 0;
      __pyx_t_4 = NULL;
    } else {
      __pyx_t_3 = -1; __pyx_t_2 = PyObject_GetIter(__pyx_v_data); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 169, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_4 = Py_TYPE(__pyx_t_2)->tp_iternext; if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 169, __pyx_L5_error)
    }
    for (;;) {
      if (likely(!__pyx_t_4)) {
        if (likely(PyList_CheckExact(__pyx_t_2))) {
          if (__pyx_t_3 >= PyList_GET_SIZE(__pyx_t_2)) break;
          #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
          __pyx_t_5 = PyList_GET_ITEM(__pyx_t_2, __pyx_t_3); __Pyx_INCREF(__pyx_t_5); __pyx_t_3++; if (unlikely(0 < 0)) __PYX_ERR(0, 169, __pyx_L5_error)
          #else
          __pyx_t_5 = PySequence_ITEM(__pyx_t_2, __pyx_t_3); __pyx_t_3++; if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 169, __pyx_L5_error)
          __Pyx_GOTREF(__pyx_t_5);
          #endif
        } else {
          if (__pyx_t_3 >= PyTuple_GET_SIZE(__pyx_t_2)) break;
          #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
          __pyx_t_5 = PyTuple_GET_ITEM(__pyx_t_2, __pyx_t_3); __Pyx_INCREF(__pyx_t_5); __pyx_t_3++; if (unlikely(0 < 0)) __PYX_ERR(0, 169, __pyx_L5_error)
          #else
          __pyx_t_5 = PySequence_ITEM(__pyx_t_2, __pyx_t_3); __pyx_t_3++; if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 169, __pyx_L5_error)
          __Pyx_GOTREF(__pyx_t_5);
          #endif
        }
      } else {
        __pyx_t_5 = __pyx_t_4(__pyx_t_2);
        if (unlikely(!__pyx_t_5)) {
          PyObject* exc_type = PyErr_Occurred();
          if (exc_type) {
            if (likely(__Pyx_PyErr_GivenExceptionMatches(exc_type, PyExc_StopIteration))) PyErr_Clear();
            else __PYX_ERR(0, 169, __pyx_L5_error)
          }
          break;
        }
        __Pyx_GOTREF(__pyx_t_5);
      }
      __Pyx_XDECREF_SET(__pyx_8genexpr1__pyx_v_x, __pyx_t_5);
      __pyx_t_5 = 0;
      __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_pos); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 169, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_7 = PyObject_RichCompare(__pyx_8genexpr1__pyx_v_x, __pyx_t_5, Py_LE); __Pyx_XGOTREF(__pyx_t_7); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 169, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_7); if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 169, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      if (__pyx_t_8) {
      } else {
        __pyx_t_6 = __pyx_t_8;
        goto __pyx_L9_bool_binop_done;
      }
      __pyx_t_7 = __Pyx_PyInt_From_npy_int32((__pyx_v_pos - __pyx_v_width)); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 169, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_7);
      __pyx_t_5 = PyObject_RichCompare(__pyx_8genexpr1__pyx_v_x, __pyx_t_7, Py_GE); __Pyx_XGOTREF(__pyx_t_5); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 169, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 169, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_6 = __pyx_t_8;
      __pyx_L9_bool_binop_done:;
      if (__pyx_t_6) {
        __pyx_t_5 = __Pyx_PyObject_GetItem(__pyx_v_data, __pyx_8genexpr1__pyx_v_x); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 169, __pyx_L5_error)
        __Pyx_GOTREF(__pyx_t_5);
        if (unlikely(__Pyx_ListComp_Append(__pyx_t_1, (PyObject*)__pyx_t_5))) __PYX_ERR(0, 169, __pyx_L5_error)
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      }
    }
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_8genexpr1__pyx_v_x); __pyx_8genexpr1__pyx_v_x = 0;
    goto __pyx_L11_exit_scope;
    __pyx_L5_error:;
    __Pyx_XDECREF(__pyx_8genexpr1__pyx_v_x); __pyx_8genexpr1__pyx_v_x = 0;
    goto __pyx_L1_error;
    __pyx_L11_exit_scope:;
  } /* exit inner scope */
  __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_sum, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 169, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_9 = __Pyx_PyInt_As_npy_int32(__pyx_t_2); if (unlikely((__pyx_t_9 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 169, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_r = __pyx_t_9;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":166
 *     return a
 * 
 * cdef inline int32_t left_sum ( data, int32_t pos, int32_t width ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.left_sum", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_8genexpr1__pyx_v_x);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":171
 *     return sum([data[x] for x in data if x <= pos and x >= pos - width])
 * 
 * cdef inline int32_t right_sum ( data, int32_t pos, int32_t width ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */

static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_right_sum(PyObject *__pyx_v_data, __pyx_t_5numpy_int32_t __pyx_v_pos, __pyx_t_5numpy_int32_t __pyx_v_width) {
  PyObject *__pyx_8genexpr2__pyx_v_x = NULL;
  __pyx_t_5numpy_int32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  Py_ssize_t __pyx_t_3;
  PyObject *(*__pyx_t_4)(PyObject *);
  PyObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  __pyx_t_5numpy_int32_t __pyx_t_9;
  __Pyx_RefNannySetupContext("right_sum", 0);
  __Pyx_TraceCall("right_sum", __pyx_f[0], 171, 0, __PYX_ERR(0, 171, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":174
 *     """
 *     """
 *     return sum([data[x] for x in data if x >= pos and x <= pos + width])             # <<<<<<<<<<<<<<
 * 
 * cdef inline int32_t left_forward ( data, int32_t pos, int32_t window_size ):
 */
  __Pyx_TraceLine(174,0,__PYX_ERR(0, 174, __pyx_L1_error))
  { /* enter inner scope */
    __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 174, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (likely(PyList_CheckExact(__pyx_v_data)) || PyTuple_CheckExact(__pyx_v_data)) {
      __pyx_t_2 = __pyx_v_data; __Pyx_INCREF(__pyx_t_2); __pyx_t_3 = 0;
      __pyx_t_4 = NULL;
    } else {
      __pyx_t_3 = -1; __pyx_t_2 = PyObject_GetIter(__pyx_v_data); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 174, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_4 = Py_TYPE(__pyx_t_2)->tp_iternext; if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 174, __pyx_L5_error)
    }
    for (;;) {
      if (likely(!__pyx_t_4)) {
        if (likely(PyList_CheckExact(__pyx_t_2))) {
          if (__pyx_t_3 >= PyList_GET_SIZE(__pyx_t_2)) break;
          #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
          __pyx_t_5 = PyList_GET_ITEM(__pyx_t_2, __pyx_t_3); __Pyx_INCREF(__pyx_t_5); __pyx_t_3++; if (unlikely(0 < 0)) __PYX_ERR(0, 174, __pyx_L5_error)
          #else
          __pyx_t_5 = PySequence_ITEM(__pyx_t_2, __pyx_t_3); __pyx_t_3++; if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 174, __pyx_L5_error)
          __Pyx_GOTREF(__pyx_t_5);
          #endif
        } else {
          if (__pyx_t_3 >= PyTuple_GET_SIZE(__pyx_t_2)) break;
          #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
          __pyx_t_5 = PyTuple_GET_ITEM(__pyx_t_2, __pyx_t_3); __Pyx_INCREF(__pyx_t_5); __pyx_t_3++; if (unlikely(0 < 0)) __PYX_ERR(0, 174, __pyx_L5_error)
          #else
          __pyx_t_5 = PySequence_ITEM(__pyx_t_2, __pyx_t_3); __pyx_t_3++; if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 174, __pyx_L5_error)
          __Pyx_GOTREF(__pyx_t_5);
          #endif
        }
      } else {
        __pyx_t_5 = __pyx_t_4(__pyx_t_2);
        if (unlikely(!__pyx_t_5)) {
          PyObject* exc_type = PyErr_Occurred();
          if (exc_type) {
            if (likely(__Pyx_PyErr_GivenExceptionMatches(exc_type, PyExc_StopIteration))) PyErr_Clear();
            else __PYX_ERR(0, 174, __pyx_L5_error)
          }
          break;
        }
        __Pyx_GOTREF(__pyx_t_5);
      }
      __Pyx_XDECREF_SET(__pyx_8genexpr2__pyx_v_x, __pyx_t_5);
      __pyx_t_5 = 0;
      __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_pos); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 174, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_7 = PyObject_RichCompare(__pyx_8genexpr2__pyx_v_x, __pyx_t_5, Py_GE); __Pyx_XGOTREF(__pyx_t_7); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 174, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_7); if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 174, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      if (__pyx_t_8) {
      } else {
        __pyx_t_6 = __pyx_t_8;
        goto __pyx_L9_bool_binop_done;
      }
      __pyx_t_7 = __Pyx_PyInt_From_npy_int32((__pyx_v_pos + __pyx_v_width)); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 174, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_7);
      __pyx_t_5 = PyObject_RichCompare(__pyx_8genexpr2__pyx_v_x, __pyx_t_7, Py_LE); __Pyx_XGOTREF(__pyx_t_5); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 174, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __pyx_t_8 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 174, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_6 = __pyx_t_8;
      __pyx_L9_bool_binop_done:;
      if (__pyx_t_6) {
        __pyx_t_5 = __Pyx_PyObject_GetItem(__pyx_v_data, __pyx_8genexpr2__pyx_v_x); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 174, __pyx_L5_error)
        __Pyx_GOTREF(__pyx_t_5);
        if (unlikely(__Pyx_ListComp_Append(__pyx_t_1, (PyObject*)__pyx_t_5))) __PYX_ERR(0, 174, __pyx_L5_error)
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      }
    }
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_8genexpr2__pyx_v_x); __pyx_8genexpr2__pyx_v_x = 0;
    goto __pyx_L11_exit_scope;
    __pyx_L5_error:;
    __Pyx_XDECREF(__pyx_8genexpr2__pyx_v_x); __pyx_8genexpr2__pyx_v_x = 0;
    goto __pyx_L1_error;
    __pyx_L11_exit_scope:;
  } /* exit inner scope */
  __pyx_t_2 = __Pyx_PyObject_CallOneArg(__pyx_builtin_sum, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 174, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_9 = __Pyx_PyInt_As_npy_int32(__pyx_t_2); if (unlikely((__pyx_t_9 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 174, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_r = __pyx_t_9;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":171
 *     return sum([data[x] for x in data if x <= pos and x >= pos - width])
 * 
 * cdef inline int32_t right_sum ( data, int32_t pos, int32_t width ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.right_sum", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_8genexpr2__pyx_v_x);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":176
 *     return sum([data[x] for x in data if x >= pos and x <= pos + width])
 * 
 * cdef inline int32_t left_forward ( data, int32_t pos, int32_t window_size ):             # <<<<<<<<<<<<<<
 *     return data.get(pos,0) - data.get(pos-window_size, 0)
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_left_forward(PyObject *__pyx_v_data, __pyx_t_5numpy_int32_t __pyx_v_pos, __pyx_t_5numpy_int32_t __pyx_v_window_size) {
  __pyx_t_5numpy_int32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  __pyx_t_5numpy_int32_t __pyx_t_8;
  __Pyx_RefNannySetupContext("left_forward", 0);
  __Pyx_TraceCall("left_forward", __pyx_f[0], 176, 0, __PYX_ERR(0, 176, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":177
 * 
 * cdef inline int32_t left_forward ( data, int32_t pos, int32_t window_size ):
 *     return data.get(pos,0) - data.get(pos-window_size, 0)             # <<<<<<<<<<<<<<
 * 
 * cdef inline int32_t right_forward ( data, int32_t pos, int32_t window_size ):
 */
  __Pyx_TraceLine(177,0,__PYX_ERR(0, 177, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_data, __pyx_n_s_get); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_pos); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
      __pyx_t_5 = 1;
    }
  }
  #if CYTHON_FAST_PYCALL
  if (PyFunction_Check(__pyx_t_2)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_1 = __Pyx_PyFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  #if CYTHON_FAST_PYCCALL
  if (__Pyx_PyFastCFunction_Check(__pyx_t_2)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_1 = __Pyx_PyCFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  {
    __pyx_t_6 = PyTuple_New(2+__pyx_t_5); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    if (__pyx_t_4) {
      __Pyx_GIVEREF(__pyx_t_4); PyTuple_SET_ITEM(__pyx_t_6, 0, __pyx_t_4); __pyx_t_4 = NULL;
    }
    __Pyx_GIVEREF(__pyx_t_3);
    PyTuple_SET_ITEM(__pyx_t_6, 0+__pyx_t_5, __pyx_t_3);
    __Pyx_INCREF(__pyx_int_0);
    __Pyx_GIVEREF(__pyx_int_0);
    PyTuple_SET_ITEM(__pyx_t_6, 1+__pyx_t_5, __pyx_int_0);
    __pyx_t_3 = 0;
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_6, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  }
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_v_data, __pyx_n_s_get); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32((__pyx_v_pos - __pyx_v_window_size)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_6))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_6);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_6, function);
      __pyx_t_5 = 1;
    }
  }
  #if CYTHON_FAST_PYCALL
  if (PyFunction_Check(__pyx_t_6)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_2 = __Pyx_PyFunction_FastCall(__pyx_t_6, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  #if CYTHON_FAST_PYCCALL
  if (__Pyx_PyFastCFunction_Check(__pyx_t_6)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_2 = __Pyx_PyCFunction_FastCall(__pyx_t_6, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  {
    __pyx_t_7 = PyTuple_New(2+__pyx_t_5); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (__pyx_t_4) {
      __Pyx_GIVEREF(__pyx_t_4); PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_t_4); __pyx_t_4 = NULL;
    }
    __Pyx_GIVEREF(__pyx_t_3);
    PyTuple_SET_ITEM(__pyx_t_7, 0+__pyx_t_5, __pyx_t_3);
    __Pyx_INCREF(__pyx_int_0);
    __Pyx_GIVEREF(__pyx_int_0);
    PyTuple_SET_ITEM(__pyx_t_7, 1+__pyx_t_5, __pyx_int_0);
    __pyx_t_3 = 0;
    __pyx_t_2 = __Pyx_PyObject_Call(__pyx_t_6, __pyx_t_7, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 177, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  }
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = PyNumber_Subtract(__pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_8 = __Pyx_PyInt_As_npy_int32(__pyx_t_6); if (unlikely((__pyx_t_8 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 177, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_r = __pyx_t_8;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":176
 *     return sum([data[x] for x in data if x >= pos and x <= pos + width])
 * 
 * cdef inline int32_t left_forward ( data, int32_t pos, int32_t window_size ):             # <<<<<<<<<<<<<<
 *     return data.get(pos,0) - data.get(pos-window_size, 0)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.left_forward", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":179
 *     return data.get(pos,0) - data.get(pos-window_size, 0)
 * 
 * cdef inline int32_t right_forward ( data, int32_t pos, int32_t window_size ):             # <<<<<<<<<<<<<<
 *     return data.get(pos + window_size, 0) - data.get(pos, 0)
 * 
 */

static CYTHON_INLINE __pyx_t_5numpy_int32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_right_forward(PyObject *__pyx_v_data, __pyx_t_5numpy_int32_t __pyx_v_pos, __pyx_t_5numpy_int32_t __pyx_v_window_size) {
  __pyx_t_5numpy_int32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  __pyx_t_5numpy_int32_t __pyx_t_8;
  __Pyx_RefNannySetupContext("right_forward", 0);
  __Pyx_TraceCall("right_forward", __pyx_f[0], 179, 0, __PYX_ERR(0, 179, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":180
 * 
 * cdef inline int32_t right_forward ( data, int32_t pos, int32_t window_size ):
 *     return data.get(pos + window_size, 0) - data.get(pos, 0)             # <<<<<<<<<<<<<<
 * 
 * cdef wtd_find_summit(chrom, np.ndarray plus, np.ndarray minus, int32_t search_start, int32_t search_end, int32_t window_size, float32_t cutoff):
 */
  __Pyx_TraceLine(180,0,__PYX_ERR(0, 180, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_data, __pyx_n_s_get); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 180, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32((__pyx_v_pos + __pyx_v_window_size)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 180, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
      __pyx_t_5 = 1;
    }
  }
  #if CYTHON_FAST_PYCALL
  if (PyFunction_Check(__pyx_t_2)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_1 = __Pyx_PyFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  #if CYTHON_FAST_PYCCALL
  if (__Pyx_PyFastCFunction_Check(__pyx_t_2)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_1 = __Pyx_PyCFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  {
    __pyx_t_6 = PyTuple_New(2+__pyx_t_5); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    if (__pyx_t_4) {
      __Pyx_GIVEREF(__pyx_t_4); PyTuple_SET_ITEM(__pyx_t_6, 0, __pyx_t_4); __pyx_t_4 = NULL;
    }
    __Pyx_GIVEREF(__pyx_t_3);
    PyTuple_SET_ITEM(__pyx_t_6, 0+__pyx_t_5, __pyx_t_3);
    __Pyx_INCREF(__pyx_int_0);
    __Pyx_GIVEREF(__pyx_int_0);
    PyTuple_SET_ITEM(__pyx_t_6, 1+__pyx_t_5, __pyx_int_0);
    __pyx_t_3 = 0;
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_6, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  }
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_v_data, __pyx_n_s_get); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 180, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_pos); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 180, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  __pyx_t_5 = 0;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_6))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_6);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_6, function);
      __pyx_t_5 = 1;
    }
  }
  #if CYTHON_FAST_PYCALL
  if (PyFunction_Check(__pyx_t_6)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_2 = __Pyx_PyFunction_FastCall(__pyx_t_6, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  #if CYTHON_FAST_PYCCALL
  if (__Pyx_PyFastCFunction_Check(__pyx_t_6)) {
    PyObject *__pyx_temp[3] = {__pyx_t_4, __pyx_t_3, __pyx_int_0};
    __pyx_t_2 = __Pyx_PyCFunction_FastCall(__pyx_t_6, __pyx_temp+1-__pyx_t_5, 2+__pyx_t_5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else
  #endif
  {
    __pyx_t_7 = PyTuple_New(2+__pyx_t_5); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (__pyx_t_4) {
      __Pyx_GIVEREF(__pyx_t_4); PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_t_4); __pyx_t_4 = NULL;
    }
    __Pyx_GIVEREF(__pyx_t_3);
    PyTuple_SET_ITEM(__pyx_t_7, 0+__pyx_t_5, __pyx_t_3);
    __Pyx_INCREF(__pyx_int_0);
    __Pyx_GIVEREF(__pyx_int_0);
    PyTuple_SET_ITEM(__pyx_t_7, 1+__pyx_t_5, __pyx_int_0);
    __pyx_t_3 = 0;
    __pyx_t_2 = __Pyx_PyObject_Call(__pyx_t_6, __pyx_t_7, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 180, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  }
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = PyNumber_Subtract(__pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 180, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_8 = __Pyx_PyInt_As_npy_int32(__pyx_t_6); if (unlikely((__pyx_t_8 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 180, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_r = __pyx_t_8;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":179
 *     return data.get(pos,0) - data.get(pos-window_size, 0)
 * 
 * cdef inline int32_t right_forward ( data, int32_t pos, int32_t window_size ):             # <<<<<<<<<<<<<<
 *     return data.get(pos + window_size, 0) - data.get(pos, 0)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.right_forward", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":182
 *     return data.get(pos + window_size, 0) - data.get(pos, 0)
 * 
 * cdef wtd_find_summit(chrom, np.ndarray plus, np.ndarray minus, int32_t search_start, int32_t search_end, int32_t window_size, float32_t cutoff):             # <<<<<<<<<<<<<<
 *     """internal function to be called by refine_peak_from_tags_distribution()
 * 
 */

static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_wtd_find_summit(CYTHON_UNUSED PyObject *__pyx_v_chrom, PyArrayObject *__pyx_v_plus, PyArrayObject *__pyx_v_minus, __pyx_t_5numpy_int32_t __pyx_v_search_start, __pyx_t_5numpy_int32_t __pyx_v_search_end, __pyx_t_5numpy_int32_t __pyx_v_window_size, __pyx_t_5numpy_float32_t __pyx_v_cutoff) {
  __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_int32_t __pyx_v_j;
  __pyx_t_5numpy_int32_t __pyx_v_watson_left;
  __pyx_t_5numpy_int32_t __pyx_v_watson_right;
  __pyx_t_5numpy_int32_t __pyx_v_crick_left;
  __pyx_t_5numpy_int32_t __pyx_v_crick_right;
  PyArrayObject *__pyx_v_wtd_list = 0;
  PyArrayObject *__pyx_v_wtd_other_max_pos = 0;
  PyArrayObject *__pyx_v_wtd_other_max_val = 0;
  PyObject *__pyx_v_watson = NULL;
  PyObject *__pyx_v_crick = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  long __pyx_t_5;
  long __pyx_t_6;
  __pyx_t_5numpy_int32_t __pyx_t_7;
  long __pyx_t_8;
  double __pyx_t_9;
  double __pyx_t_10;
  int __pyx_t_11;
  __Pyx_RefNannySetupContext("wtd_find_summit", 0);
  __Pyx_TraceCall("wtd_find_summit", __pyx_f[0], 182, 0, __PYX_ERR(0, 182, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":191
 *         np.ndarray wtd_list, wtd_other_max_pos, wtd_other_max_val
 * 
 *     watson, crick = (Counter(plus), Counter(minus))             # <<<<<<<<<<<<<<
 *     watson_left = left_sum(watson, search_start, window_size)
 *     crick_left = left_sum(crick, search_start, window_size)
 */
  __Pyx_TraceLine(191,0,__PYX_ERR(0, 191, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_Counter); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_1 = (__pyx_t_3) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_3, ((PyObject *)__pyx_v_plus)) : __Pyx_PyObject_CallOneArg(__pyx_t_2, ((PyObject *)__pyx_v_plus));
  __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_Counter); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
    }
  }
  __pyx_t_2 = (__pyx_t_4) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_4, ((PyObject *)__pyx_v_minus)) : __Pyx_PyObject_CallOneArg(__pyx_t_3, ((PyObject *)__pyx_v_minus));
  __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_watson = __pyx_t_1;
  __pyx_t_1 = 0;
  __pyx_v_crick = __pyx_t_2;
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":192
 * 
 *     watson, crick = (Counter(plus), Counter(minus))
 *     watson_left = left_sum(watson, search_start, window_size)             # <<<<<<<<<<<<<<
 *     crick_left = left_sum(crick, search_start, window_size)
 *     watson_right = right_sum(watson, search_start, window_size)
 */
  __Pyx_TraceLine(192,0,__PYX_ERR(0, 192, __pyx_L1_error))
  __pyx_v_watson_left = __pyx_f_5MACS2_2IO_12CallPeakUnit_left_sum(__pyx_v_watson, __pyx_v_search_start, __pyx_v_window_size);

  /* "MACS2/IO/CallPeakUnit.pyx":193
 *     watson, crick = (Counter(plus), Counter(minus))
 *     watson_left = left_sum(watson, search_start, window_size)
 *     crick_left = left_sum(crick, search_start, window_size)             # <<<<<<<<<<<<<<
 *     watson_right = right_sum(watson, search_start, window_size)
 *     crick_right = right_sum(crick, search_start, window_size)
 */
  __Pyx_TraceLine(193,0,__PYX_ERR(0, 193, __pyx_L1_error))
  __pyx_v_crick_left = __pyx_f_5MACS2_2IO_12CallPeakUnit_left_sum(__pyx_v_crick, __pyx_v_search_start, __pyx_v_window_size);

  /* "MACS2/IO/CallPeakUnit.pyx":194
 *     watson_left = left_sum(watson, search_start, window_size)
 *     crick_left = left_sum(crick, search_start, window_size)
 *     watson_right = right_sum(watson, search_start, window_size)             # <<<<<<<<<<<<<<
 *     crick_right = right_sum(crick, search_start, window_size)
 * 
 */
  __Pyx_TraceLine(194,0,__PYX_ERR(0, 194, __pyx_L1_error))
  __pyx_v_watson_right = __pyx_f_5MACS2_2IO_12CallPeakUnit_right_sum(__pyx_v_watson, __pyx_v_search_start, __pyx_v_window_size);

  /* "MACS2/IO/CallPeakUnit.pyx":195
 *     crick_left = left_sum(crick, search_start, window_size)
 *     watson_right = right_sum(watson, search_start, window_size)
 *     crick_right = right_sum(crick, search_start, window_size)             # <<<<<<<<<<<<<<
 * 
 *     wtd_list = np.zeros( search_end - search_start + 1, dtype="float32")
 */
  __Pyx_TraceLine(195,0,__PYX_ERR(0, 195, __pyx_L1_error))
  __pyx_v_crick_right = __pyx_f_5MACS2_2IO_12CallPeakUnit_right_sum(__pyx_v_crick, __pyx_v_search_start, __pyx_v_window_size);

  /* "MACS2/IO/CallPeakUnit.pyx":197
 *     crick_right = right_sum(crick, search_start, window_size)
 * 
 *     wtd_list = np.zeros( search_end - search_start + 1, dtype="float32")             # <<<<<<<<<<<<<<
 *     i = 0
 *     for j in range(search_start, search_end+1):
 */
  __Pyx_TraceLine(197,0,__PYX_ERR(0, 197, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_np); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 197, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_zeros); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 197, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyInt_From_long(((__pyx_v_search_end - __pyx_v_search_start) + 1)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 197, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 197, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 197, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 197, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 197, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 197, __pyx_L1_error)
  __pyx_v_wtd_list = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":198
 * 
 *     wtd_list = np.zeros( search_end - search_start + 1, dtype="float32")
 *     i = 0             # <<<<<<<<<<<<<<
 *     for j in range(search_start, search_end+1):
 *         wtd_list[i] = max((2 * (watson_left * crick_right)**0.5 - watson_right - crick_left),0) # minimum score is 0
 */
  __Pyx_TraceLine(198,0,__PYX_ERR(0, 198, __pyx_L1_error))
  __pyx_v_i = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":199
 *     wtd_list = np.zeros( search_end - search_start + 1, dtype="float32")
 *     i = 0
 *     for j in range(search_start, search_end+1):             # <<<<<<<<<<<<<<
 *         wtd_list[i] = max((2 * (watson_left * crick_right)**0.5 - watson_right - crick_left),0) # minimum score is 0
 *         watson_left += left_forward(watson, j, window_size)
 */
  __Pyx_TraceLine(199,0,__PYX_ERR(0, 199, __pyx_L1_error))
  __pyx_t_5 = (__pyx_v_search_end + 1);
  __pyx_t_6 = __pyx_t_5;
  for (__pyx_t_7 = __pyx_v_search_start; __pyx_t_7 < __pyx_t_6; __pyx_t_7+=1) {
    __pyx_v_j = __pyx_t_7;

    /* "MACS2/IO/CallPeakUnit.pyx":200
 *     i = 0
 *     for j in range(search_start, search_end+1):
 *         wtd_list[i] = max((2 * (watson_left * crick_right)**0.5 - watson_right - crick_left),0) # minimum score is 0             # <<<<<<<<<<<<<<
 *         watson_left += left_forward(watson, j, window_size)
 *         watson_right += right_forward(watson, j, window_size)
 */
    __Pyx_TraceLine(200,0,__PYX_ERR(0, 200, __pyx_L1_error))
    __pyx_t_8 = 0;
    __pyx_t_9 = (((2.0 * pow(((double)(__pyx_v_watson_left * __pyx_v_crick_right)), 0.5)) - __pyx_v_watson_right) - __pyx_v_crick_left);
    if (((__pyx_t_8 > __pyx_t_9) != 0)) {
      __pyx_t_10 = __pyx_t_8;
    } else {
      __pyx_t_10 = __pyx_t_9;
    }
    __pyx_t_4 = PyFloat_FromDouble(__pyx_t_10); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 200, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    if (unlikely(__Pyx_SetItemInt(((PyObject *)__pyx_v_wtd_list), __pyx_v_i, __pyx_t_4, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1) < 0)) __PYX_ERR(0, 200, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":201
 *     for j in range(search_start, search_end+1):
 *         wtd_list[i] = max((2 * (watson_left * crick_right)**0.5 - watson_right - crick_left),0) # minimum score is 0
 *         watson_left += left_forward(watson, j, window_size)             # <<<<<<<<<<<<<<
 *         watson_right += right_forward(watson, j, window_size)
 *         crick_left += left_forward(crick, j, window_size)
 */
    __Pyx_TraceLine(201,0,__PYX_ERR(0, 201, __pyx_L1_error))
    __pyx_v_watson_left = (__pyx_v_watson_left + __pyx_f_5MACS2_2IO_12CallPeakUnit_left_forward(__pyx_v_watson, __pyx_v_j, __pyx_v_window_size));

    /* "MACS2/IO/CallPeakUnit.pyx":202
 *         wtd_list[i] = max((2 * (watson_left * crick_right)**0.5 - watson_right - crick_left),0) # minimum score is 0
 *         watson_left += left_forward(watson, j, window_size)
 *         watson_right += right_forward(watson, j, window_size)             # <<<<<<<<<<<<<<
 *         crick_left += left_forward(crick, j, window_size)
 *         crick_right += right_forward(crick, j, window_size)
 */
    __Pyx_TraceLine(202,0,__PYX_ERR(0, 202, __pyx_L1_error))
    __pyx_v_watson_right = (__pyx_v_watson_right + __pyx_f_5MACS2_2IO_12CallPeakUnit_right_forward(__pyx_v_watson, __pyx_v_j, __pyx_v_window_size));

    /* "MACS2/IO/CallPeakUnit.pyx":203
 *         watson_left += left_forward(watson, j, window_size)
 *         watson_right += right_forward(watson, j, window_size)
 *         crick_left += left_forward(crick, j, window_size)             # <<<<<<<<<<<<<<
 *         crick_right += right_forward(crick, j, window_size)
 *         i += 1
 */
    __Pyx_TraceLine(203,0,__PYX_ERR(0, 203, __pyx_L1_error))
    __pyx_v_crick_left = (__pyx_v_crick_left + __pyx_f_5MACS2_2IO_12CallPeakUnit_left_forward(__pyx_v_crick, __pyx_v_j, __pyx_v_window_size));

    /* "MACS2/IO/CallPeakUnit.pyx":204
 *         watson_right += right_forward(watson, j, window_size)
 *         crick_left += left_forward(crick, j, window_size)
 *         crick_right += right_forward(crick, j, window_size)             # <<<<<<<<<<<<<<
 *         i += 1
 * 
 */
    __Pyx_TraceLine(204,0,__PYX_ERR(0, 204, __pyx_L1_error))
    __pyx_v_crick_right = (__pyx_v_crick_right + __pyx_f_5MACS2_2IO_12CallPeakUnit_right_forward(__pyx_v_crick, __pyx_v_j, __pyx_v_window_size));

    /* "MACS2/IO/CallPeakUnit.pyx":205
 *         crick_left += left_forward(crick, j, window_size)
 *         crick_right += right_forward(crick, j, window_size)
 *         i += 1             # <<<<<<<<<<<<<<
 * 
 *     wtd_other_max_pos = maxima(wtd_list, window_size = window_size)
 */
    __Pyx_TraceLine(205,0,__PYX_ERR(0, 205, __pyx_L1_error))
    __pyx_v_i = (__pyx_v_i + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":207
 *         i += 1
 * 
 *     wtd_other_max_pos = maxima(wtd_list, window_size = window_size)             # <<<<<<<<<<<<<<
 *     wtd_other_max_pos = enforce_peakyness( wtd_list, wtd_other_max_pos )
 *     wtd_other_max_val = wtd_list[wtd_other_max_pos]
 */
  __Pyx_TraceLine(207,0,__PYX_ERR(0, 207, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_maxima); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 207, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 207, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(((PyObject *)__pyx_v_wtd_list));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_wtd_list));
  PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_v_wtd_list));
  __pyx_t_3 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 207, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_window_size); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 207, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_3, __pyx_n_s_window_size, __pyx_t_1) < 0) __PYX_ERR(0, 207, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_4, __pyx_t_2, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 207, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 207, __pyx_L1_error)
  __pyx_v_wtd_other_max_pos = ((PyArrayObject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":208
 * 
 *     wtd_other_max_pos = maxima(wtd_list, window_size = window_size)
 *     wtd_other_max_pos = enforce_peakyness( wtd_list, wtd_other_max_pos )             # <<<<<<<<<<<<<<
 *     wtd_other_max_val = wtd_list[wtd_other_max_pos]
 *     wtd_other_max_pos = wtd_other_max_pos + search_start
 */
  __Pyx_TraceLine(208,0,__PYX_ERR(0, 208, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_enforce_peakyness); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 208, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_2 = NULL;
  __pyx_t_11 = 0;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
      __pyx_t_11 = 1;
    }
  }
  #if CYTHON_FAST_PYCALL
  if (PyFunction_Check(__pyx_t_3)) {
    PyObject *__pyx_temp[3] = {__pyx_t_2, ((PyObject *)__pyx_v_wtd_list), ((PyObject *)__pyx_v_wtd_other_max_pos)};
    __pyx_t_1 = __Pyx_PyFunction_FastCall(__pyx_t_3, __pyx_temp+1-__pyx_t_11, 2+__pyx_t_11); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 208, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_GOTREF(__pyx_t_1);
  } else
  #endif
  #if CYTHON_FAST_PYCCALL
  if (__Pyx_PyFastCFunction_Check(__pyx_t_3)) {
    PyObject *__pyx_temp[3] = {__pyx_t_2, ((PyObject *)__pyx_v_wtd_list), ((PyObject *)__pyx_v_wtd_other_max_pos)};
    __pyx_t_1 = __Pyx_PyCFunction_FastCall(__pyx_t_3, __pyx_temp+1-__pyx_t_11, 2+__pyx_t_11); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 208, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_GOTREF(__pyx_t_1);
  } else
  #endif
  {
    __pyx_t_4 = PyTuple_New(2+__pyx_t_11); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 208, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    if (__pyx_t_2) {
      __Pyx_GIVEREF(__pyx_t_2); PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_2); __pyx_t_2 = NULL;
    }
    __Pyx_INCREF(((PyObject *)__pyx_v_wtd_list));
    __Pyx_GIVEREF(((PyObject *)__pyx_v_wtd_list));
    PyTuple_SET_ITEM(__pyx_t_4, 0+__pyx_t_11, ((PyObject *)__pyx_v_wtd_list));
    __Pyx_INCREF(((PyObject *)__pyx_v_wtd_other_max_pos));
    __Pyx_GIVEREF(((PyObject *)__pyx_v_wtd_other_max_pos));
    PyTuple_SET_ITEM(__pyx_t_4, 1+__pyx_t_11, ((PyObject *)__pyx_v_wtd_other_max_pos));
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_3, __pyx_t_4, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 208, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  }
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 208, __pyx_L1_error)
  __Pyx_DECREF_SET(__pyx_v_wtd_other_max_pos, ((PyArrayObject *)__pyx_t_1));
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":209
 *     wtd_other_max_pos = maxima(wtd_list, window_size = window_size)
 *     wtd_other_max_pos = enforce_peakyness( wtd_list, wtd_other_max_pos )
 *     wtd_other_max_val = wtd_list[wtd_other_max_pos]             # <<<<<<<<<<<<<<
 *     wtd_other_max_pos = wtd_other_max_pos + search_start
 * 
 */
  __Pyx_TraceLine(209,0,__PYX_ERR(0, 209, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_wtd_list), ((PyObject *)__pyx_v_wtd_other_max_pos)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 209, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 209, __pyx_L1_error)
  __pyx_v_wtd_other_max_val = ((PyArrayObject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":210
 *     wtd_other_max_pos = enforce_peakyness( wtd_list, wtd_other_max_pos )
 *     wtd_other_max_val = wtd_list[wtd_other_max_pos]
 *     wtd_other_max_pos = wtd_other_max_pos + search_start             # <<<<<<<<<<<<<<
 * 
 *     return (wtd_other_max_pos, wtd_other_max_val > cutoff)
 */
  __Pyx_TraceLine(210,0,__PYX_ERR(0, 210, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_search_start); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 210, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyNumber_Add(((PyObject *)__pyx_v_wtd_other_max_pos), __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 210, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 210, __pyx_L1_error)
  __Pyx_DECREF_SET(__pyx_v_wtd_other_max_pos, ((PyArrayObject *)__pyx_t_3));
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":212
 *     wtd_other_max_pos = wtd_other_max_pos + search_start
 * 
 *     return (wtd_other_max_pos, wtd_other_max_val > cutoff)             # <<<<<<<<<<<<<<
 * 
 * cdef float32_t median_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):
 */
  __Pyx_TraceLine(212,0,__PYX_ERR(0, 212, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_3 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 212, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_1 = PyObject_RichCompare(((PyObject *)__pyx_v_wtd_other_max_val), __pyx_t_3, Py_GT); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 212, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 212, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_INCREF(((PyObject *)__pyx_v_wtd_other_max_pos));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_wtd_other_max_pos));
  PyTuple_SET_ITEM(__pyx_t_3, 0, ((PyObject *)__pyx_v_wtd_other_max_pos));
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_r = __pyx_t_3;
  __pyx_t_3 = 0;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":182
 *     return data.get(pos + window_size, 0) - data.get(pos, 0)
 * 
 * cdef wtd_find_summit(chrom, np.ndarray plus, np.ndarray minus, int32_t search_start, int32_t search_end, int32_t window_size, float32_t cutoff):             # <<<<<<<<<<<<<<
 *     """internal function to be called by refine_peak_from_tags_distribution()
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.wtd_find_summit", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_wtd_list);
  __Pyx_XDECREF((PyObject *)__pyx_v_wtd_other_max_pos);
  __Pyx_XDECREF((PyObject *)__pyx_v_wtd_other_max_val);
  __Pyx_XDECREF(__pyx_v_watson);
  __Pyx_XDECREF(__pyx_v_crick);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":214
 *     return (wtd_other_max_pos, wtd_other_max_val > cutoff)
 * 
 * cdef float32_t median_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */

static __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_median_from_value_length(PyArrayObject *__pyx_v_value, PyObject *__pyx_v_length) {
  PyObject *__pyx_v_tmp = 0;
  __pyx_t_5numpy_int32_t __pyx_v_c;
  __pyx_t_5numpy_int32_t __pyx_v_tmp_l;
  __pyx_t_5numpy_float32_t __pyx_v_tmp_v;
  __pyx_t_5numpy_float32_t __pyx_v_mid_l;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_value;
  __Pyx_Buffer __pyx_pybuffer_value;
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  __pyx_t_5numpy_float32_t __pyx_t_5;
  Py_ssize_t __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *(*__pyx_t_9)(PyObject *);
  __pyx_t_5numpy_int32_t __pyx_t_10;
  int __pyx_t_11;
  __Pyx_RefNannySetupContext("median_from_value_length", 0);
  __Pyx_TraceCall("median_from_value_length", __pyx_f[0], 214, 0, __PYX_ERR(0, 214, __pyx_L1_error));
  __pyx_pybuffer_value.pybuffer.buf = NULL;
  __pyx_pybuffer_value.refcount = 0;
  __pyx_pybuffernd_value.data = NULL;
  __pyx_pybuffernd_value.rcbuffer = &__pyx_pybuffer_value;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_value.rcbuffer->pybuffer, (PyObject*)__pyx_v_value, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 214, __pyx_L1_error)
  }
  __pyx_pybuffernd_value.diminfo[0].strides = __pyx_pybuffernd_value.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_value.diminfo[0].shape = __pyx_pybuffernd_value.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":222
 *         float32_t tmp_v, mid_l
 * 
 *     c = 0             # <<<<<<<<<<<<<<
 *     tmp = sorted(list(zip( value, length )))
 *     mid_l = sum( length )/2
 */
  __Pyx_TraceLine(222,0,__PYX_ERR(0, 222, __pyx_L1_error))
  __pyx_v_c = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":223
 * 
 *     c = 0
 *     tmp = sorted(list(zip( value, length )))             # <<<<<<<<<<<<<<
 *     mid_l = sum( length )/2
 *     for (tmp_v, tmp_l) in tmp:
 */
  __Pyx_TraceLine(223,0,__PYX_ERR(0, 223, __pyx_L1_error))
  __pyx_t_2 = PyTuple_New(2); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 223, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(((PyObject *)__pyx_v_value));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_value));
  PyTuple_SET_ITEM(__pyx_t_2, 0, ((PyObject *)__pyx_v_value));
  __Pyx_INCREF(__pyx_v_length);
  __Pyx_GIVEREF(__pyx_v_length);
  PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_v_length);
  __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_zip, __pyx_t_2, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 223, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = PySequence_List(__pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 223, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = PySequence_List(__pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 223, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_1 = ((PyObject*)__pyx_t_3);
  __pyx_t_3 = 0;
  __pyx_t_4 = PyList_Sort(__pyx_t_1); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(0, 223, __pyx_L1_error)
  __pyx_v_tmp = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":224
 *     c = 0
 *     tmp = sorted(list(zip( value, length )))
 *     mid_l = sum( length )/2             # <<<<<<<<<<<<<<
 *     for (tmp_v, tmp_l) in tmp:
 *         c += tmp_l
 */
  __Pyx_TraceLine(224,0,__PYX_ERR(0, 224, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_CallOneArg(__pyx_builtin_sum, __pyx_v_length); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 224, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = __Pyx_PyInt_TrueDivideObjC(__pyx_t_1, __pyx_int_2, 2, 0, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 224, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_5 = __pyx_PyFloat_AsFloat(__pyx_t_3); if (unlikely((__pyx_t_5 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 224, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_mid_l = __pyx_t_5;

  /* "MACS2/IO/CallPeakUnit.pyx":225
 *     tmp = sorted(list(zip( value, length )))
 *     mid_l = sum( length )/2
 *     for (tmp_v, tmp_l) in tmp:             # <<<<<<<<<<<<<<
 *         c += tmp_l
 *         if c > mid_l:
 */
  __Pyx_TraceLine(225,0,__PYX_ERR(0, 225, __pyx_L1_error))
  if (unlikely(__pyx_v_tmp == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
    __PYX_ERR(0, 225, __pyx_L1_error)
  }
  __pyx_t_3 = __pyx_v_tmp; __Pyx_INCREF(__pyx_t_3); __pyx_t_6 = 0;
  for (;;) {
    if (__pyx_t_6 >= PyList_GET_SIZE(__pyx_t_3)) break;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_1 = PyList_GET_ITEM(__pyx_t_3, __pyx_t_6); __Pyx_INCREF(__pyx_t_1); __pyx_t_6++; if (unlikely(0 < 0)) __PYX_ERR(0, 225, __pyx_L1_error)
    #else
    __pyx_t_1 = PySequence_ITEM(__pyx_t_3, __pyx_t_6); __pyx_t_6++; if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 225, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    #endif
    if ((likely(PyTuple_CheckExact(__pyx_t_1))) || (PyList_CheckExact(__pyx_t_1))) {
      PyObject* sequence = __pyx_t_1;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 2)) {
        if (size > 2) __Pyx_RaiseTooManyValuesError(2);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 225, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      if (likely(PyTuple_CheckExact(sequence))) {
        __pyx_t_2 = PyTuple_GET_ITEM(sequence, 0); 
        __pyx_t_7 = PyTuple_GET_ITEM(sequence, 1); 
      } else {
        __pyx_t_2 = PyList_GET_ITEM(sequence, 0); 
        __pyx_t_7 = PyList_GET_ITEM(sequence, 1); 
      }
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_7);
      #else
      __pyx_t_2 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 225, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_7 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 225, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_7);
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    } else {
      Py_ssize_t index = -1;
      __pyx_t_8 = PyObject_GetIter(__pyx_t_1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 225, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_9 = Py_TYPE(__pyx_t_8)->tp_iternext;
      index = 0; __pyx_t_2 = __pyx_t_9(__pyx_t_8); if (unlikely(!__pyx_t_2)) goto __pyx_L5_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_2);
      index = 1; __pyx_t_7 = __pyx_t_9(__pyx_t_8); if (unlikely(!__pyx_t_7)) goto __pyx_L5_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_7);
      if (__Pyx_IternextUnpackEndCheck(__pyx_t_9(__pyx_t_8), 2) < 0) __PYX_ERR(0, 225, __pyx_L1_error)
      __pyx_t_9 = NULL;
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      goto __pyx_L6_unpacking_done;
      __pyx_L5_unpacking_failed:;
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __pyx_t_9 = NULL;
      if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
      __PYX_ERR(0, 225, __pyx_L1_error)
      __pyx_L6_unpacking_done:;
    }
    __pyx_t_5 = __pyx_PyFloat_AsFloat(__pyx_t_2); if (unlikely((__pyx_t_5 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 225, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_10 = __Pyx_PyInt_As_npy_int32(__pyx_t_7); if (unlikely((__pyx_t_10 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 225, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __pyx_v_tmp_v = __pyx_t_5;
    __pyx_v_tmp_l = __pyx_t_10;

    /* "MACS2/IO/CallPeakUnit.pyx":226
 *     mid_l = sum( length )/2
 *     for (tmp_v, tmp_l) in tmp:
 *         c += tmp_l             # <<<<<<<<<<<<<<
 *         if c > mid_l:
 *             return tmp_v
 */
    __Pyx_TraceLine(226,0,__PYX_ERR(0, 226, __pyx_L1_error))
    __pyx_v_c = (__pyx_v_c + __pyx_v_tmp_l);

    /* "MACS2/IO/CallPeakUnit.pyx":227
 *     for (tmp_v, tmp_l) in tmp:
 *         c += tmp_l
 *         if c > mid_l:             # <<<<<<<<<<<<<<
 *             return tmp_v
 * 
 */
    __Pyx_TraceLine(227,0,__PYX_ERR(0, 227, __pyx_L1_error))
    __pyx_t_11 = ((__pyx_v_c > __pyx_v_mid_l) != 0);
    if (__pyx_t_11) {

      /* "MACS2/IO/CallPeakUnit.pyx":228
 *         c += tmp_l
 *         if c > mid_l:
 *             return tmp_v             # <<<<<<<<<<<<<<
 * 
 * cdef float32_t mean_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):
 */
      __Pyx_TraceLine(228,0,__PYX_ERR(0, 228, __pyx_L1_error))
      __pyx_r = __pyx_v_tmp_v;
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      goto __pyx_L0;

      /* "MACS2/IO/CallPeakUnit.pyx":227
 *     for (tmp_v, tmp_l) in tmp:
 *         c += tmp_l
 *         if c > mid_l:             # <<<<<<<<<<<<<<
 *             return tmp_v
 * 
 */
    }

    /* "MACS2/IO/CallPeakUnit.pyx":225
 *     tmp = sorted(list(zip( value, length )))
 *     mid_l = sum( length )/2
 *     for (tmp_v, tmp_l) in tmp:             # <<<<<<<<<<<<<<
 *         c += tmp_l
 *         if c > mid_l:
 */
    __Pyx_TraceLine(225,0,__PYX_ERR(0, 225, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":214
 *     return (wtd_other_max_pos, wtd_other_max_val > cutoff)
 * 
 * cdef float32_t median_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_value.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.median_from_value_length", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_value.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF(__pyx_v_tmp);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":230
 *             return tmp_v
 * 
 * cdef float32_t mean_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):             # <<<<<<<<<<<<<<
 *     """take list of values and list of corresponding lengths, calculate the mean.
 *     An important function for bedGraph type of data.
 */

static __pyx_t_5numpy_float32_t __pyx_f_5MACS2_2IO_12CallPeakUnit_mean_from_value_length(PyArrayObject *__pyx_v_value, PyObject *__pyx_v_length) {
  __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_int32_t __pyx_v_tmp_l;
  __pyx_t_5numpy_int32_t __pyx_v_l;
  __pyx_t_5numpy_float64_t __pyx_v_tmp_v;
  __pyx_t_5numpy_float64_t __pyx_v_sum_v;
  __pyx_t_5numpy_float64_t __pyx_v_tmp_sum;
  __pyx_t_5numpy_float32_t __pyx_v_ret;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_value;
  __Pyx_Buffer __pyx_pybuffer_value;
  __pyx_t_5numpy_float32_t __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  Py_ssize_t __pyx_t_1;
  Py_ssize_t __pyx_t_2;
  __pyx_t_5numpy_int32_t __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  __pyx_t_5numpy_int32_t __pyx_t_5;
  Py_ssize_t __pyx_t_6;
  int __pyx_t_7;
  __Pyx_RefNannySetupContext("mean_from_value_length", 0);
  __Pyx_TraceCall("mean_from_value_length", __pyx_f[0], 230, 0, __PYX_ERR(0, 230, __pyx_L1_error));
  __pyx_pybuffer_value.pybuffer.buf = NULL;
  __pyx_pybuffer_value.refcount = 0;
  __pyx_pybuffernd_value.data = NULL;
  __pyx_pybuffernd_value.rcbuffer = &__pyx_pybuffer_value;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_value.rcbuffer->pybuffer, (PyObject*)__pyx_v_value, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 230, __pyx_L1_error)
  }
  __pyx_pybuffernd_value.diminfo[0].strides = __pyx_pybuffernd_value.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_value.diminfo[0].shape = __pyx_pybuffernd_value.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":240
 *         float32_t ret
 * 
 *     sum_v = 0             # <<<<<<<<<<<<<<
 *     l = 0
 * 
 */
  __Pyx_TraceLine(240,0,__PYX_ERR(0, 240, __pyx_L1_error))
  __pyx_v_sum_v = 0.0;

  /* "MACS2/IO/CallPeakUnit.pyx":241
 * 
 *     sum_v = 0
 *     l = 0             # <<<<<<<<<<<<<<
 * 
 *     for i in range( len(length) ):
 */
  __Pyx_TraceLine(241,0,__PYX_ERR(0, 241, __pyx_L1_error))
  __pyx_v_l = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":243
 *     l = 0
 * 
 *     for i in range( len(length) ):             # <<<<<<<<<<<<<<
 *         tmp_l = length[ i ]
 *         tmp_v = <float64_t>value[ i ]
 */
  __Pyx_TraceLine(243,0,__PYX_ERR(0, 243, __pyx_L1_error))
  if (unlikely(__pyx_v_length == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 243, __pyx_L1_error)
  }
  __pyx_t_1 = PyList_GET_SIZE(__pyx_v_length); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 243, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_1;
  for (__pyx_t_3 = 0; __pyx_t_3 < __pyx_t_2; __pyx_t_3+=1) {
    __pyx_v_i = __pyx_t_3;

    /* "MACS2/IO/CallPeakUnit.pyx":244
 * 
 *     for i in range( len(length) ):
 *         tmp_l = length[ i ]             # <<<<<<<<<<<<<<
 *         tmp_v = <float64_t>value[ i ]
 *         tmp_sum = tmp_v * tmp_l
 */
    __Pyx_TraceLine(244,0,__PYX_ERR(0, 244, __pyx_L1_error))
    if (unlikely(__pyx_v_length == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 244, __pyx_L1_error)
    }
    __pyx_t_4 = __Pyx_GetItemInt_List(__pyx_v_length, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 244, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_5 = __Pyx_PyInt_As_npy_int32(__pyx_t_4); if (unlikely((__pyx_t_5 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 244, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_v_tmp_l = __pyx_t_5;

    /* "MACS2/IO/CallPeakUnit.pyx":245
 *     for i in range( len(length) ):
 *         tmp_l = length[ i ]
 *         tmp_v = <float64_t>value[ i ]             # <<<<<<<<<<<<<<
 *         tmp_sum = tmp_v * tmp_l
 *         sum_v = tmp_sum + sum_v
 */
    __Pyx_TraceLine(245,0,__PYX_ERR(0, 245, __pyx_L1_error))
    __pyx_t_6 = __pyx_v_i;
    __pyx_t_7 = -1;
    if (__pyx_t_6 < 0) {
      __pyx_t_6 += __pyx_pybuffernd_value.diminfo[0].shape;
      if (unlikely(__pyx_t_6 < 0)) __pyx_t_7 = 0;
    } else if (unlikely(__pyx_t_6 >= __pyx_pybuffernd_value.diminfo[0].shape)) __pyx_t_7 = 0;
    if (unlikely(__pyx_t_7 != -1)) {
      __Pyx_RaiseBufferIndexError(__pyx_t_7);
      __PYX_ERR(0, 245, __pyx_L1_error)
    }
    __pyx_v_tmp_v = ((__pyx_t_5numpy_float64_t)(*__Pyx_BufPtrStrided1d(__pyx_t_5numpy_float32_t *, __pyx_pybuffernd_value.rcbuffer->pybuffer.buf, __pyx_t_6, __pyx_pybuffernd_value.diminfo[0].strides)));

    /* "MACS2/IO/CallPeakUnit.pyx":246
 *         tmp_l = length[ i ]
 *         tmp_v = <float64_t>value[ i ]
 *         tmp_sum = tmp_v * tmp_l             # <<<<<<<<<<<<<<
 *         sum_v = tmp_sum + sum_v
 *         l += tmp_l
 */
    __Pyx_TraceLine(246,0,__PYX_ERR(0, 246, __pyx_L1_error))
    __pyx_v_tmp_sum = (__pyx_v_tmp_v * __pyx_v_tmp_l);

    /* "MACS2/IO/CallPeakUnit.pyx":247
 *         tmp_v = <float64_t>value[ i ]
 *         tmp_sum = tmp_v * tmp_l
 *         sum_v = tmp_sum + sum_v             # <<<<<<<<<<<<<<
 *         l += tmp_l
 * 
 */
    __Pyx_TraceLine(247,0,__PYX_ERR(0, 247, __pyx_L1_error))
    __pyx_v_sum_v = (__pyx_v_tmp_sum + __pyx_v_sum_v);

    /* "MACS2/IO/CallPeakUnit.pyx":248
 *         tmp_sum = tmp_v * tmp_l
 *         sum_v = tmp_sum + sum_v
 *         l += tmp_l             # <<<<<<<<<<<<<<
 * 
 *     ret = <float32_t>(sum_v/l)
 */
    __Pyx_TraceLine(248,0,__PYX_ERR(0, 248, __pyx_L1_error))
    __pyx_v_l = (__pyx_v_l + __pyx_v_tmp_l);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":250
 *         l += tmp_l
 * 
 *     ret = <float32_t>(sum_v/l)             # <<<<<<<<<<<<<<
 * 
 *     return ret
 */
  __Pyx_TraceLine(250,0,__PYX_ERR(0, 250, __pyx_L1_error))
  if (unlikely(__pyx_v_l == 0)) {
    PyErr_SetString(PyExc_ZeroDivisionError, "float division");
    __PYX_ERR(0, 250, __pyx_L1_error)
  }
  __pyx_v_ret = ((__pyx_t_5numpy_float32_t)(__pyx_v_sum_v / ((__pyx_t_5numpy_float64_t)__pyx_v_l)));

  /* "MACS2/IO/CallPeakUnit.pyx":252
 *     ret = <float32_t>(sum_v/l)
 * 
 *     return ret             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_TraceLine(252,0,__PYX_ERR(0, 252, __pyx_L1_error))
  __pyx_r = __pyx_v_ret;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":230
 *             return tmp_v
 * 
 * cdef float32_t mean_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):             # <<<<<<<<<<<<<<
 *     """take list of values and list of corresponding lengths, calculate the mean.
 *     An important function for bedGraph type of data.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_value.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.mean_from_value_length", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_value.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":255
 * 
 * 
 * cdef tuple find_optimal_cutoff( list x, list y ):             # <<<<<<<<<<<<<<
 *     """Return the best cutoff x and y.
 * 
 */

static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_find_optimal_cutoff(PyObject *__pyx_v_x, PyObject *__pyx_v_y) {
  PyArrayObject *__pyx_v_npx = 0;
  PyArrayObject *__pyx_v_npy = 0;
  PyArrayObject *__pyx_v_npA = 0;
  __pyx_t_5numpy_int64_t __pyx_v_l;
  __pyx_t_5numpy_int64_t __pyx_v_i;
  __pyx_t_5numpy_float32_t __pyx_v_m;
  __pyx_t_5numpy_float32_t __pyx_v_c;
  __pyx_t_5numpy_float32_t __pyx_v_sst;
  __pyx_t_5numpy_float32_t __pyx_v_sse;
  CYTHON_UNUSED __pyx_t_5numpy_float32_t __pyx_v_rsq;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  Py_ssize_t __pyx_t_1;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  __pyx_t_5numpy_int64_t __pyx_t_8;
  __pyx_t_5numpy_int64_t __pyx_t_9;
  __pyx_t_5numpy_int64_t __pyx_t_10;
  PyObject *(*__pyx_t_11)(PyObject *);
  __pyx_t_5numpy_float32_t __pyx_t_12;
  __pyx_t_5numpy_float32_t __pyx_t_13;
  __Pyx_RefNannySetupContext("find_optimal_cutoff", 0);
  __Pyx_TraceCall("find_optimal_cutoff", __pyx_f[0], 255, 0, __PYX_ERR(0, 255, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":274
 *         float32_t rsq # R-squared
 * 
 *     l = len(x)             # <<<<<<<<<<<<<<
 *     assert l == len(y)
 *     npx = np.array( x )
 */
  __Pyx_TraceLine(274,0,__PYX_ERR(0, 274, __pyx_L1_error))
  if (unlikely(__pyx_v_x == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 274, __pyx_L1_error)
  }
  __pyx_t_1 = PyList_GET_SIZE(__pyx_v_x); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 274, __pyx_L1_error)
  __pyx_v_l = __pyx_t_1;

  /* "MACS2/IO/CallPeakUnit.pyx":275
 * 
 *     l = len(x)
 *     assert l == len(y)             # <<<<<<<<<<<<<<
 *     npx = np.array( x )
 *     npy = np.log10( np.array( y ) )
 */
  __Pyx_TraceLine(275,0,__PYX_ERR(0, 275, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(__pyx_v_y == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 275, __pyx_L1_error)
    }
    __pyx_t_1 = PyList_GET_SIZE(__pyx_v_y); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 275, __pyx_L1_error)
    if (unlikely(!((__pyx_v_l == __pyx_t_1) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 275, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":276
 *     l = len(x)
 *     assert l == len(y)
 *     npx = np.array( x )             # <<<<<<<<<<<<<<
 *     npy = np.log10( np.array( y ) )
 *     npA = np.vstack( [npx, np.ones(len(npx))] ).T
 */
  __Pyx_TraceLine(276,0,__PYX_ERR(0, 276, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_np); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 276, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_array); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 276, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_4))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_4);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_4, function);
    }
  }
  __pyx_t_2 = (__pyx_t_3) ? __Pyx_PyObject_Call2Args(__pyx_t_4, __pyx_t_3, __pyx_v_x) : __Pyx_PyObject_CallOneArg(__pyx_t_4, __pyx_v_x);
  __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 276, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 276, __pyx_L1_error)
  __pyx_v_npx = ((PyArrayObject *)__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":277
 *     assert l == len(y)
 *     npx = np.array( x )
 *     npy = np.log10( np.array( y ) )             # <<<<<<<<<<<<<<
 *     npA = np.vstack( [npx, np.ones(len(npx))] ).T
 * 
 */
  __Pyx_TraceLine(277,0,__PYX_ERR(0, 277, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_np); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 277, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_log10); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 277, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_np); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 277, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_array); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 277, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_6))) {
    __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_6);
    if (likely(__pyx_t_5)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
      __Pyx_INCREF(__pyx_t_5);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_6, function);
    }
  }
  __pyx_t_4 = (__pyx_t_5) ? __Pyx_PyObject_Call2Args(__pyx_t_6, __pyx_t_5, __pyx_v_y) : __Pyx_PyObject_CallOneArg(__pyx_t_6, __pyx_v_y);
  __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 277, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
    }
  }
  __pyx_t_2 = (__pyx_t_6) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_6, __pyx_t_4) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_t_4);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 277, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 277, __pyx_L1_error)
  __pyx_v_npy = ((PyArrayObject *)__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":278
 *     npx = np.array( x )
 *     npy = np.log10( np.array( y ) )
 *     npA = np.vstack( [npx, np.ones(len(npx))] ).T             # <<<<<<<<<<<<<<
 * 
 *     for i in range( 10, l ):
 */
  __Pyx_TraceLine(278,0,__PYX_ERR(0, 278, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_np); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_vstack); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_np); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_ones); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_1 = PyObject_Length(((PyObject *)__pyx_v_npx)); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 278, __pyx_L1_error)
  __pyx_t_6 = PyInt_FromSsize_t(__pyx_t_1); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_7 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_7)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_7);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_3 = (__pyx_t_7) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_7, __pyx_t_6) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = PyList_New(2); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_INCREF(((PyObject *)__pyx_v_npx));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_npx));
  PyList_SET_ITEM(__pyx_t_5, 0, ((PyObject *)__pyx_v_npx));
  __Pyx_GIVEREF(__pyx_t_3);
  PyList_SET_ITEM(__pyx_t_5, 1, __pyx_t_3);
  __pyx_t_3 = 0;
  __pyx_t_3 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_4))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_4);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_4, function);
    }
  }
  __pyx_t_2 = (__pyx_t_3) ? __Pyx_PyObject_Call2Args(__pyx_t_4, __pyx_t_3, __pyx_t_5) : __Pyx_PyObject_CallOneArg(__pyx_t_4, __pyx_t_5);
  __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_T); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 278, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 278, __pyx_L1_error)
  __pyx_v_npA = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":280
 *     npA = np.vstack( [npx, np.ones(len(npx))] ).T
 * 
 *     for i in range( 10, l ):             # <<<<<<<<<<<<<<
 *         # at least the largest 10 points
 *         m, c = np.linalg.lstsq( npA[:i], npy[:i], rcond=None )[ 0 ]
 */
  __Pyx_TraceLine(280,0,__PYX_ERR(0, 280, __pyx_L1_error))
  __pyx_t_8 = __pyx_v_l;
  __pyx_t_9 = __pyx_t_8;
  for (__pyx_t_10 = 10; __pyx_t_10 < __pyx_t_9; __pyx_t_10+=1) {
    __pyx_v_i = __pyx_t_10;

    /* "MACS2/IO/CallPeakUnit.pyx":282
 *     for i in range( 10, l ):
 *         # at least the largest 10 points
 *         m, c = np.linalg.lstsq( npA[:i], npy[:i], rcond=None )[ 0 ]             # <<<<<<<<<<<<<<
 *         sst = sum( ( npy[:i] - np.mean( npy[:i] ) ) ** 2 )
 *         sse = sum( ( npy[:i] - m*npx[:i] - c ) ** 2 )
 */
    __Pyx_TraceLine(282,0,__PYX_ERR(0, 282, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_np); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_linalg); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_lstsq); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyObject_GetSlice(((PyObject *)__pyx_v_npA), 0, __pyx_v_i, NULL, NULL, NULL, 0, 1, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_5 = __Pyx_PyObject_GetSlice(((PyObject *)__pyx_v_npy), 0, __pyx_v_i, NULL, NULL, NULL, 0, 1, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_2);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
    __Pyx_GIVEREF(__pyx_t_5);
    PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_5);
    __pyx_t_2 = 0;
    __pyx_t_5 = 0;
    __pyx_t_5 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    if (PyDict_SetItem(__pyx_t_5, __pyx_n_s_rcond, Py_None) < 0) __PYX_ERR(0, 282, __pyx_L1_error)
    __pyx_t_2 = __Pyx_PyObject_Call(__pyx_t_4, __pyx_t_3, __pyx_t_5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __pyx_t_5 = __Pyx_GetItemInt(__pyx_t_2, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if ((likely(PyTuple_CheckExact(__pyx_t_5))) || (PyList_CheckExact(__pyx_t_5))) {
      PyObject* sequence = __pyx_t_5;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 2)) {
        if (size > 2) __Pyx_RaiseTooManyValuesError(2);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 282, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      if (likely(PyTuple_CheckExact(sequence))) {
        __pyx_t_2 = PyTuple_GET_ITEM(sequence, 0); 
        __pyx_t_3 = PyTuple_GET_ITEM(sequence, 1); 
      } else {
        __pyx_t_2 = PyList_GET_ITEM(sequence, 0); 
        __pyx_t_3 = PyList_GET_ITEM(sequence, 1); 
      }
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      #else
      __pyx_t_2 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 282, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_3 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 282, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      #endif
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    } else {
      Py_ssize_t index = -1;
      __pyx_t_4 = PyObject_GetIter(__pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 282, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_11 = Py_TYPE(__pyx_t_4)->tp_iternext;
      index = 0; __pyx_t_2 = __pyx_t_11(__pyx_t_4); if (unlikely(!__pyx_t_2)) goto __pyx_L5_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_2);
      index = 1; __pyx_t_3 = __pyx_t_11(__pyx_t_4); if (unlikely(!__pyx_t_3)) goto __pyx_L5_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_3);
      if (__Pyx_IternextUnpackEndCheck(__pyx_t_11(__pyx_t_4), 2) < 0) __PYX_ERR(0, 282, __pyx_L1_error)
      __pyx_t_11 = NULL;
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      goto __pyx_L6_unpacking_done;
      __pyx_L5_unpacking_failed:;
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_11 = NULL;
      if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
      __PYX_ERR(0, 282, __pyx_L1_error)
      __pyx_L6_unpacking_done:;
    }
    __pyx_t_12 = __pyx_PyFloat_AsFloat(__pyx_t_2); if (unlikely((__pyx_t_12 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_13 = __pyx_PyFloat_AsFloat(__pyx_t_3); if (unlikely((__pyx_t_13 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 282, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_v_m = __pyx_t_12;
    __pyx_v_c = __pyx_t_13;

    /* "MACS2/IO/CallPeakUnit.pyx":283
 *         # at least the largest 10 points
 *         m, c = np.linalg.lstsq( npA[:i], npy[:i], rcond=None )[ 0 ]
 *         sst = sum( ( npy[:i] - np.mean( npy[:i] ) ) ** 2 )             # <<<<<<<<<<<<<<
 *         sse = sum( ( npy[:i] - m*npx[:i] - c ) ** 2 )
 *         rsq = 1 - sse/sst
 */
    __Pyx_TraceLine(283,0,__PYX_ERR(0, 283, __pyx_L1_error))
    __pyx_t_5 = __Pyx_PyObject_GetSlice(((PyObject *)__pyx_v_npy), 0, __pyx_v_i, NULL, NULL, NULL, 0, 1, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_np); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_mean); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyObject_GetSlice(((PyObject *)__pyx_v_npy), 0, __pyx_v_i, NULL, NULL, NULL, 0, 1, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_6 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_4))) {
      __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_4);
      if (likely(__pyx_t_6)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
        __Pyx_INCREF(__pyx_t_6);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_4, function);
      }
    }
    __pyx_t_3 = (__pyx_t_6) ? __Pyx_PyObject_Call2Args(__pyx_t_4, __pyx_t_6, __pyx_t_2) : __Pyx_PyObject_CallOneArg(__pyx_t_4, __pyx_t_2);
    __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_4 = PyNumber_Subtract(__pyx_t_5, __pyx_t_3); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = PyNumber_Power(__pyx_t_4, __pyx_int_2, Py_None); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_4 = __Pyx_PyObject_CallOneArg(__pyx_builtin_sum, __pyx_t_3); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_13 = __pyx_PyFloat_AsFloat(__pyx_t_4); if (unlikely((__pyx_t_13 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 283, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_v_sst = __pyx_t_13;

    /* "MACS2/IO/CallPeakUnit.pyx":284
 *         m, c = np.linalg.lstsq( npA[:i], npy[:i], rcond=None )[ 0 ]
 *         sst = sum( ( npy[:i] - np.mean( npy[:i] ) ) ** 2 )
 *         sse = sum( ( npy[:i] - m*npx[:i] - c ) ** 2 )             # <<<<<<<<<<<<<<
 *         rsq = 1 - sse/sst
 *         #print i, x[i], y[i], m, c, rsq
 */
    __Pyx_TraceLine(284,0,__PYX_ERR(0, 284, __pyx_L1_error))
    __pyx_t_4 = __Pyx_PyObject_GetSlice(((PyObject *)__pyx_v_npy), 0, __pyx_v_i, NULL, NULL, NULL, 0, 1, 1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_3 = PyFloat_FromDouble(__pyx_v_m); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_5 = __Pyx_PyObject_GetSlice(((PyObject *)__pyx_v_npx), 0, __pyx_v_i, NULL, NULL, NULL, 0, 1, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_2 = PyNumber_Multiply(__pyx_t_3, __pyx_t_5); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __pyx_t_5 = PyNumber_Subtract(__pyx_t_4, __pyx_t_2); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = PyFloat_FromDouble(__pyx_v_c); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_4 = PyNumber_Subtract(__pyx_t_5, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = PyNumber_Power(__pyx_t_4, __pyx_int_2, Py_None); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_4 = __Pyx_PyObject_CallOneArg(__pyx_builtin_sum, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_13 = __pyx_PyFloat_AsFloat(__pyx_t_4); if (unlikely((__pyx_t_13 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 284, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_v_sse = __pyx_t_13;

    /* "MACS2/IO/CallPeakUnit.pyx":285
 *         sst = sum( ( npy[:i] - np.mean( npy[:i] ) ) ** 2 )
 *         sse = sum( ( npy[:i] - m*npx[:i] - c ) ** 2 )
 *         rsq = 1 - sse/sst             # <<<<<<<<<<<<<<
 *         #print i, x[i], y[i], m, c, rsq
 *     return ( 1.0, 1.0 )
 */
    __Pyx_TraceLine(285,0,__PYX_ERR(0, 285, __pyx_L1_error))
    if (unlikely(__pyx_v_sst == 0)) {
      PyErr_SetString(PyExc_ZeroDivisionError, "float division");
      __PYX_ERR(0, 285, __pyx_L1_error)
    }
    __pyx_v_rsq = (1.0 - (__pyx_v_sse / __pyx_v_sst));
  }

  /* "MACS2/IO/CallPeakUnit.pyx":287
 *         rsq = 1 - sse/sst
 *         #print i, x[i], y[i], m, c, rsq
 *     return ( 1.0, 1.0 )             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_TraceLine(287,0,__PYX_ERR(0, 287, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_tuple__2);
  __pyx_r = __pyx_tuple__2;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":255
 * 
 * 
 * cdef tuple find_optimal_cutoff( list x, list y ):             # <<<<<<<<<<<<<<
 *     """Return the best cutoff x and y.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.find_optimal_cutoff", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_npx);
  __Pyx_XDECREF((PyObject *)__pyx_v_npy);
  __Pyx_XDECREF((PyObject *)__pyx_v_npA);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":344
 * 
 * 
 *     def __init__ (self, treat, ctrl,             # <<<<<<<<<<<<<<
 *                   int32_t d = 200, list ctrl_d_s = [200, 1000, 10000],
 *                   float32_t treat_scaling_factor = 1.0, list ctrl_scaling_factor_s = [1.0, 0.2, 0.02],
 */

/* Python wrapper */
static int __pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static char __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__[] = "Initialize.\n\n        A calculator is unique to each comparison of treat and\n        control. Treat_depth and ctrl_depth should not be changed\n        during calculation.\n\n        treat and ctrl are two FWTrack or PETrackI objects.\n\n        treat_depth and ctrl_depth are effective depth in million:\n                                    sequencing depth in million after\n                                    duplicates being filtered. If\n                                    treatment is scaled down to\n                                    control sample size, then this\n                                    should be control sample size in\n                                    million. And vice versa.\n\n        d, sregion, lregion: d is the fragment size, sregion is the\n                             small region size, lregion is the large\n                             region size\n                                    \n        pseudocount: a pseudocount used to calculate logLR, FE or\n                     logFE. Please note this value will not be changed\n                     with normalization method. So if you really want\n                     to set pseudocount 1 per million reads, set it\n                     after you normalize treat and control by million\n                     reads by `change_normalizetion_method(ord('M'))`.\n\n        ";
#if CYTHON_COMPILING_IN_CPYTHON
struct wrapperbase __pyx_wrapperbase_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__;
#endif
static int __pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_1__init__(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_treat = 0;
  PyObject *__pyx_v_ctrl = 0;
  __pyx_t_5numpy_int32_t __pyx_v_d;
  PyObject *__pyx_v_ctrl_d_s = 0;
  __pyx_t_5numpy_float32_t __pyx_v_treat_scaling_factor;
  PyObject *__pyx_v_ctrl_scaling_factor_s = 0;
  CYTHON_UNUSED PyBoolObject *__pyx_v_stderr_on = 0;
  __pyx_t_5numpy_float32_t __pyx_v_pseudocount;
  __pyx_t_5numpy_int32_t __pyx_v_end_shift;
  __pyx_t_5numpy_float32_t __pyx_v_lambda_bg;
  PyBoolObject *__pyx_v_save_bedGraph = 0;
  PyObject *__pyx_v_bedGraph_filename_prefix = 0;
  PyObject *__pyx_v_bedGraph_treat_filename = 0;
  PyObject *__pyx_v_bedGraph_control_filename = 0;
  PyObject *__pyx_v_cutoff_analysis_filename = 0;
  PyBoolObject *__pyx_v_save_SPMR = 0;
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__init__ (wrapper)", 0);
  {
    static PyObject **__pyx_pyargnames[] = {&__pyx_n_s_treat,&__pyx_n_s_ctrl,&__pyx_n_s_d,&__pyx_n_s_ctrl_d_s,&__pyx_n_s_treat_scaling_factor,&__pyx_n_s_ctrl_scaling_factor_s,&__pyx_n_s_stderr_on,&__pyx_n_s_pseudocount,&__pyx_n_s_end_shift,&__pyx_n_s_lambda_bg,&__pyx_n_s_save_bedGraph,&__pyx_n_s_bedGraph_filename_prefix,&__pyx_n_s_bedGraph_treat_filename,&__pyx_n_s_bedGraph_control_filename,&__pyx_n_s_cutoff_analysis_filename,&__pyx_n_s_save_SPMR,0};
    PyObject* values[16] = {0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0};
    values[3] = __pyx_k__3;
    values[5] = __pyx_k__4;

    /* "MACS2/IO/CallPeakUnit.pyx":347
 *                   int32_t d = 200, list ctrl_d_s = [200, 1000, 10000],
 *                   float32_t treat_scaling_factor = 1.0, list ctrl_scaling_factor_s = [1.0, 0.2, 0.02],
 *                   bool stderr_on = False,             # <<<<<<<<<<<<<<
 *                   float32_t pseudocount = 1,
 *                   int32_t end_shift = 0,
 */
    values[6] = (PyObject *)((PyBoolObject *)Py_False);

    /* "MACS2/IO/CallPeakUnit.pyx":351
 *                   int32_t end_shift = 0,
 *                   float32_t lambda_bg = 0,
 *                   bool save_bedGraph = False,             # <<<<<<<<<<<<<<
 *                   str  bedGraph_filename_prefix = "PREFIX",
 *                   str bedGraph_treat_filename = "TREAT.bdg",
 */
    values[10] = (PyObject *)((PyBoolObject *)Py_False);
    values[11] = ((PyObject*)__pyx_n_u_PREFIX);
    values[12] = ((PyObject*)__pyx_kp_u_TREAT_bdg);
    values[13] = ((PyObject*)__pyx_kp_u_CTRL_bdg);
    values[14] = ((PyObject*)__pyx_kp_u_TMP_txt);

    /* "MACS2/IO/CallPeakUnit.pyx":356
 *                   str bedGraph_control_filename = "CTRL.bdg",
 *                   str cutoff_analysis_filename = "TMP.txt",
 *                   bool save_SPMR = False ):             # <<<<<<<<<<<<<<
 *         """Initialize.
 * 
 */
    values[15] = (PyObject *)((PyBoolObject *)Py_False);
    if (unlikely(__pyx_kwds)) {
      Py_ssize_t kw_args;
      const Py_ssize_t pos_args = PyTuple_GET_SIZE(__pyx_args);
      switch (pos_args) {
        case 16: values[15] = PyTuple_GET_ITEM(__pyx_args, 15);
        CYTHON_FALLTHROUGH;
        case 15: values[14] = PyTuple_GET_ITEM(__pyx_args, 14);
        CYTHON_FALLTHROUGH;
        case 14: values[13] = PyTuple_GET_ITEM(__pyx_args, 13);
        CYTHON_FALLTHROUGH;
        case 13: values[12] = PyTuple_GET_ITEM(__pyx_args, 12);
        CYTHON_FALLTHROUGH;
        case 12: values[11] = PyTuple_GET_ITEM(__pyx_args, 11);
        CYTHON_FALLTHROUGH;
        case 11: values[10] = PyTuple_GET_ITEM(__pyx_args, 10);
        CYTHON_FALLTHROUGH;
        case 10: values[9] = PyTuple_GET_ITEM(__pyx_args, 9);
        CYTHON_FALLTHROUGH;
        case  9: values[8] = PyTuple_GET_ITEM(__pyx_args, 8);
        CYTHON_FALLTHROUGH;
        case  8: values[7] = PyTuple_GET_ITEM(__pyx_args, 7);
        CYTHON_FALLTHROUGH;
        case  7: values[6] = PyTuple_GET_ITEM(__pyx_args, 6);
        CYTHON_FALLTHROUGH;
        case  6: values[5] = PyTuple_GET_ITEM(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = PyTuple_GET_ITEM(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = PyDict_Size(__pyx_kwds);
      switch (pos_args) {
        case  0:
        if (likely((values[0] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_treat)) != 0)) kw_args--;
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_ctrl)) != 0)) kw_args--;
        else {
          __Pyx_RaiseArgtupleInvalid("__init__", 0, 2, 16, 1); __PYX_ERR(0, 344, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_d);
          if (value) { values[2] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  3:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_ctrl_d_s);
          if (value) { values[3] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  4:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_treat_scaling_factor);
          if (value) { values[4] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  5:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_ctrl_scaling_factor_s);
          if (value) { values[5] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  6:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_stderr_on);
          if (value) { values[6] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  7:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_pseudocount);
          if (value) { values[7] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  8:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_end_shift);
          if (value) { values[8] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  9:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_lambda_bg);
          if (value) { values[9] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case 10:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_save_bedGraph);
          if (value) { values[10] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case 11:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_bedGraph_filename_prefix);
          if (value) { values[11] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case 12:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_bedGraph_treat_filename);
          if (value) { values[12] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case 13:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_bedGraph_control_filename);
          if (value) { values[13] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case 14:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_cutoff_analysis_filename);
          if (value) { values[14] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case 15:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_save_SPMR);
          if (value) { values[15] = value; kw_args--; }
        }
      }
      if (unlikely(kw_args > 0)) {
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_pyargnames, 0, values, pos_args, "__init__") < 0)) __PYX_ERR(0, 344, __pyx_L3_error)
      }
    } else {
      switch (PyTuple_GET_SIZE(__pyx_args)) {
        case 16: values[15] = PyTuple_GET_ITEM(__pyx_args, 15);
        CYTHON_FALLTHROUGH;
        case 15: values[14] = PyTuple_GET_ITEM(__pyx_args, 14);
        CYTHON_FALLTHROUGH;
        case 14: values[13] = PyTuple_GET_ITEM(__pyx_args, 13);
        CYTHON_FALLTHROUGH;
        case 13: values[12] = PyTuple_GET_ITEM(__pyx_args, 12);
        CYTHON_FALLTHROUGH;
        case 12: values[11] = PyTuple_GET_ITEM(__pyx_args, 11);
        CYTHON_FALLTHROUGH;
        case 11: values[10] = PyTuple_GET_ITEM(__pyx_args, 10);
        CYTHON_FALLTHROUGH;
        case 10: values[9] = PyTuple_GET_ITEM(__pyx_args, 9);
        CYTHON_FALLTHROUGH;
        case  9: values[8] = PyTuple_GET_ITEM(__pyx_args, 8);
        CYTHON_FALLTHROUGH;
        case  8: values[7] = PyTuple_GET_ITEM(__pyx_args, 7);
        CYTHON_FALLTHROUGH;
        case  7: values[6] = PyTuple_GET_ITEM(__pyx_args, 6);
        CYTHON_FALLTHROUGH;
        case  6: values[5] = PyTuple_GET_ITEM(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = PyTuple_GET_ITEM(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_treat = values[0];
    __pyx_v_ctrl = values[1];
    if (values[2]) {
      __pyx_v_d = __Pyx_PyInt_As_npy_int32(values[2]); if (unlikely((__pyx_v_d == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 345, __pyx_L3_error)
    } else {
      __pyx_v_d = ((__pyx_t_5numpy_int32_t)0xC8);
    }
    __pyx_v_ctrl_d_s = ((PyObject*)values[3]);
    if (values[4]) {
      __pyx_v_treat_scaling_factor = __pyx_PyFloat_AsFloat(values[4]); if (unlikely((__pyx_v_treat_scaling_factor == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 346, __pyx_L3_error)
    } else {
      __pyx_v_treat_scaling_factor = ((__pyx_t_5numpy_float32_t)1.0);
    }
    __pyx_v_ctrl_scaling_factor_s = ((PyObject*)values[5]);
    __pyx_v_stderr_on = ((PyBoolObject *)values[6]);
    if (values[7]) {
      __pyx_v_pseudocount = __pyx_PyFloat_AsFloat(values[7]); if (unlikely((__pyx_v_pseudocount == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 348, __pyx_L3_error)
    } else {
      __pyx_v_pseudocount = ((__pyx_t_5numpy_float32_t)1.0);
    }
    if (values[8]) {
      __pyx_v_end_shift = __Pyx_PyInt_As_npy_int32(values[8]); if (unlikely((__pyx_v_end_shift == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 349, __pyx_L3_error)
    } else {
      __pyx_v_end_shift = ((__pyx_t_5numpy_int32_t)0);
    }
    if (values[9]) {
      __pyx_v_lambda_bg = __pyx_PyFloat_AsFloat(values[9]); if (unlikely((__pyx_v_lambda_bg == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 350, __pyx_L3_error)
    } else {
      __pyx_v_lambda_bg = ((__pyx_t_5numpy_float32_t)0.0);
    }
    __pyx_v_save_bedGraph = ((PyBoolObject *)values[10]);
    __pyx_v_bedGraph_filename_prefix = ((PyObject*)values[11]);
    __pyx_v_bedGraph_treat_filename = ((PyObject*)values[12]);
    __pyx_v_bedGraph_control_filename = ((PyObject*)values[13]);
    __pyx_v_cutoff_analysis_filename = ((PyObject*)values[14]);
    __pyx_v_save_SPMR = ((PyBoolObject *)values[15]);
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("__init__", 0, 2, 16, PyTuple_GET_SIZE(__pyx_args)); __PYX_ERR(0, 344, __pyx_L3_error)
  __pyx_L3_error:;
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return -1;
  __pyx_L4_argument_unpacking_done:;
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_ctrl_d_s), (&PyList_Type), 1, "ctrl_d_s", 1))) __PYX_ERR(0, 345, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_ctrl_scaling_factor_s), (&PyList_Type), 1, "ctrl_scaling_factor_s", 1))) __PYX_ERR(0, 346, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_stderr_on), __pyx_ptype_7cpython_4bool_bool, 1, "stderr_on", 0))) __PYX_ERR(0, 347, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_save_bedGraph), __pyx_ptype_7cpython_4bool_bool, 1, "save_bedGraph", 0))) __PYX_ERR(0, 351, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_bedGraph_filename_prefix), (&PyUnicode_Type), 1, "bedGraph_filename_prefix", 1))) __PYX_ERR(0, 352, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_bedGraph_treat_filename), (&PyUnicode_Type), 1, "bedGraph_treat_filename", 1))) __PYX_ERR(0, 353, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_bedGraph_control_filename), (&PyUnicode_Type), 1, "bedGraph_control_filename", 1))) __PYX_ERR(0, 354, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_cutoff_analysis_filename), (&PyUnicode_Type), 1, "cutoff_analysis_filename", 1))) __PYX_ERR(0, 355, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_save_SPMR), __pyx_ptype_7cpython_4bool_bool, 1, "save_SPMR", 0))) __PYX_ERR(0, 356, __pyx_L1_error)
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self), __pyx_v_treat, __pyx_v_ctrl, __pyx_v_d, __pyx_v_ctrl_d_s, __pyx_v_treat_scaling_factor, __pyx_v_ctrl_scaling_factor_s, __pyx_v_stderr_on, __pyx_v_pseudocount, __pyx_v_end_shift, __pyx_v_lambda_bg, __pyx_v_save_bedGraph, __pyx_v_bedGraph_filename_prefix, __pyx_v_bedGraph_treat_filename, __pyx_v_bedGraph_control_filename, __pyx_v_cutoff_analysis_filename, __pyx_v_save_SPMR);

  /* "MACS2/IO/CallPeakUnit.pyx":344
 * 
 * 
 *     def __init__ (self, treat, ctrl,             # <<<<<<<<<<<<<<
 *                   int32_t d = 200, list ctrl_d_s = [200, 1000, 10000],
 *                   float32_t treat_scaling_factor = 1.0, list ctrl_scaling_factor_s = [1.0, 0.2, 0.02],
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_treat, PyObject *__pyx_v_ctrl, __pyx_t_5numpy_int32_t __pyx_v_d, PyObject *__pyx_v_ctrl_d_s, __pyx_t_5numpy_float32_t __pyx_v_treat_scaling_factor, PyObject *__pyx_v_ctrl_scaling_factor_s, CYTHON_UNUSED PyBoolObject *__pyx_v_stderr_on, __pyx_t_5numpy_float32_t __pyx_v_pseudocount, __pyx_t_5numpy_int32_t __pyx_v_end_shift, __pyx_t_5numpy_float32_t __pyx_v_lambda_bg, PyBoolObject *__pyx_v_save_bedGraph, PyObject *__pyx_v_bedGraph_filename_prefix, PyObject *__pyx_v_bedGraph_treat_filename, PyObject *__pyx_v_bedGraph_control_filename, PyObject *__pyx_v_cutoff_analysis_filename, PyBoolObject *__pyx_v_save_SPMR) {
  PyObject *__pyx_v_chr1 = 0;
  PyObject *__pyx_v_chr2 = 0;
  __pyx_t_5numpy_float32_t __pyx_v_p;
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  int __pyx_t_2;
  int __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  int __pyx_t_7;
  Py_ssize_t __pyx_t_8;
  PyObject *(*__pyx_t_9)(PyObject *);
  __pyx_t_5numpy_float32_t __pyx_t_10;
  __Pyx_RefNannySetupContext("__init__", 0);
  __Pyx_TraceCall("__init__", __pyx_f[0], 344, 0, __PYX_ERR(0, 344, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":393
 * 
 * 
 *         if isinstance(treat, FWTrack):             # <<<<<<<<<<<<<<
 *             self.PE_mode = False
 *         elif isinstance(treat, PETrackI):
 */
  __Pyx_TraceLine(393,0,__PYX_ERR(0, 393, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_FWTrack); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 393, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = PyObject_IsInstance(__pyx_v_treat, __pyx_t_1); if (unlikely(__pyx_t_2 == ((int)-1))) __PYX_ERR(0, 393, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_3 = (__pyx_t_2 != 0);
  if (__pyx_t_3) {

    /* "MACS2/IO/CallPeakUnit.pyx":394
 * 
 *         if isinstance(treat, FWTrack):
 *             self.PE_mode = False             # <<<<<<<<<<<<<<
 *         elif isinstance(treat, PETrackI):
 *             self.PE_mode = True
 */
    __Pyx_TraceLine(394,0,__PYX_ERR(0, 394, __pyx_L1_error))
    __Pyx_INCREF(Py_False);
    __Pyx_GIVEREF(Py_False);
    __Pyx_GOTREF(__pyx_v_self->PE_mode);
    __Pyx_DECREF(((PyObject *)__pyx_v_self->PE_mode));
    __pyx_v_self->PE_mode = ((PyBoolObject *)Py_False);

    /* "MACS2/IO/CallPeakUnit.pyx":393
 * 
 * 
 *         if isinstance(treat, FWTrack):             # <<<<<<<<<<<<<<
 *             self.PE_mode = False
 *         elif isinstance(treat, PETrackI):
 */
    goto __pyx_L3;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":395
 *         if isinstance(treat, FWTrack):
 *             self.PE_mode = False
 *         elif isinstance(treat, PETrackI):             # <<<<<<<<<<<<<<
 *             self.PE_mode = True
 *         else:
 */
  __Pyx_TraceLine(395,0,__PYX_ERR(0, 395, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_PETrackI); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 395, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyObject_IsInstance(__pyx_v_treat, __pyx_t_1); if (unlikely(__pyx_t_3 == ((int)-1))) __PYX_ERR(0, 395, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_2 = (__pyx_t_3 != 0);
  if (likely(__pyx_t_2)) {

    /* "MACS2/IO/CallPeakUnit.pyx":396
 *             self.PE_mode = False
 *         elif isinstance(treat, PETrackI):
 *             self.PE_mode = True             # <<<<<<<<<<<<<<
 *         else:
 *             raise Exception("Should be FWTrack or PETrackI object!")
 */
    __Pyx_TraceLine(396,0,__PYX_ERR(0, 396, __pyx_L1_error))
    __Pyx_INCREF(Py_True);
    __Pyx_GIVEREF(Py_True);
    __Pyx_GOTREF(__pyx_v_self->PE_mode);
    __Pyx_DECREF(((PyObject *)__pyx_v_self->PE_mode));
    __pyx_v_self->PE_mode = ((PyBoolObject *)Py_True);

    /* "MACS2/IO/CallPeakUnit.pyx":395
 *         if isinstance(treat, FWTrack):
 *             self.PE_mode = False
 *         elif isinstance(treat, PETrackI):             # <<<<<<<<<<<<<<
 *             self.PE_mode = True
 *         else:
 */
    goto __pyx_L3;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":398
 *             self.PE_mode = True
 *         else:
 *             raise Exception("Should be FWTrack or PETrackI object!")             # <<<<<<<<<<<<<<
 * 
 *         self.treat = treat
 */
  __Pyx_TraceLine(398,0,__PYX_ERR(0, 398, __pyx_L1_error))
  /*else*/ {
    __pyx_t_1 = __Pyx_PyObject_Call(((PyObject *)(&((PyTypeObject*)PyExc_Exception)[0])), __pyx_tuple__5, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 398, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_Raise(__pyx_t_1, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __PYX_ERR(0, 398, __pyx_L1_error)
  }
  __pyx_L3:;

  /* "MACS2/IO/CallPeakUnit.pyx":400
 *             raise Exception("Should be FWTrack or PETrackI object!")
 * 
 *         self.treat = treat             # <<<<<<<<<<<<<<
 *         if ctrl:
 *             self.ctrl = ctrl
 */
  __Pyx_TraceLine(400,0,__PYX_ERR(0, 400, __pyx_L1_error))
  __Pyx_INCREF(__pyx_v_treat);
  __Pyx_GIVEREF(__pyx_v_treat);
  __Pyx_GOTREF(__pyx_v_self->treat);
  __Pyx_DECREF(__pyx_v_self->treat);
  __pyx_v_self->treat = __pyx_v_treat;

  /* "MACS2/IO/CallPeakUnit.pyx":401
 * 
 *         self.treat = treat
 *         if ctrl:             # <<<<<<<<<<<<<<
 *             self.ctrl = ctrl
 *         else:                   # while there is no control
 */
  __Pyx_TraceLine(401,0,__PYX_ERR(0, 401, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyObject_IsTrue(__pyx_v_ctrl); if (unlikely(__pyx_t_2 < 0)) __PYX_ERR(0, 401, __pyx_L1_error)
  if (__pyx_t_2) {

    /* "MACS2/IO/CallPeakUnit.pyx":402
 *         self.treat = treat
 *         if ctrl:
 *             self.ctrl = ctrl             # <<<<<<<<<<<<<<
 *         else:                   # while there is no control
 *             self.ctrl = treat
 */
    __Pyx_TraceLine(402,0,__PYX_ERR(0, 402, __pyx_L1_error))
    __Pyx_INCREF(__pyx_v_ctrl);
    __Pyx_GIVEREF(__pyx_v_ctrl);
    __Pyx_GOTREF(__pyx_v_self->ctrl);
    __Pyx_DECREF(__pyx_v_self->ctrl);
    __pyx_v_self->ctrl = __pyx_v_ctrl;

    /* "MACS2/IO/CallPeakUnit.pyx":401
 * 
 *         self.treat = treat
 *         if ctrl:             # <<<<<<<<<<<<<<
 *             self.ctrl = ctrl
 *         else:                   # while there is no control
 */
    goto __pyx_L4;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":404
 *             self.ctrl = ctrl
 *         else:                   # while there is no control
 *             self.ctrl = treat             # <<<<<<<<<<<<<<
 *         self.trackline = False
 *         self.d = d              # note, self.d doesn't make sense in PE mode
 */
  __Pyx_TraceLine(404,0,__PYX_ERR(0, 404, __pyx_L1_error))
  /*else*/ {
    __Pyx_INCREF(__pyx_v_treat);
    __Pyx_GIVEREF(__pyx_v_treat);
    __Pyx_GOTREF(__pyx_v_self->ctrl);
    __Pyx_DECREF(__pyx_v_self->ctrl);
    __pyx_v_self->ctrl = __pyx_v_treat;
  }
  __pyx_L4:;

  /* "MACS2/IO/CallPeakUnit.pyx":405
 *         else:                   # while there is no control
 *             self.ctrl = treat
 *         self.trackline = False             # <<<<<<<<<<<<<<
 *         self.d = d              # note, self.d doesn't make sense in PE mode
 *         self.ctrl_d_s = ctrl_d_s# note, self.d doesn't make sense in PE mode
 */
  __Pyx_TraceLine(405,0,__PYX_ERR(0, 405, __pyx_L1_error))
  __Pyx_INCREF(Py_False);
  __Pyx_GIVEREF(Py_False);
  __Pyx_GOTREF(__pyx_v_self->trackline);
  __Pyx_DECREF(((PyObject *)__pyx_v_self->trackline));
  __pyx_v_self->trackline = ((PyBoolObject *)Py_False);

  /* "MACS2/IO/CallPeakUnit.pyx":406
 *             self.ctrl = treat
 *         self.trackline = False
 *         self.d = d              # note, self.d doesn't make sense in PE mode             # <<<<<<<<<<<<<<
 *         self.ctrl_d_s = ctrl_d_s# note, self.d doesn't make sense in PE mode
 *         self.treat_scaling_factor = treat_scaling_factor
 */
  __Pyx_TraceLine(406,0,__PYX_ERR(0, 406, __pyx_L1_error))
  __pyx_v_self->d = __pyx_v_d;

  /* "MACS2/IO/CallPeakUnit.pyx":407
 *         self.trackline = False
 *         self.d = d              # note, self.d doesn't make sense in PE mode
 *         self.ctrl_d_s = ctrl_d_s# note, self.d doesn't make sense in PE mode             # <<<<<<<<<<<<<<
 *         self.treat_scaling_factor = treat_scaling_factor
 *         self.ctrl_scaling_factor_s= ctrl_scaling_factor_s
 */
  __Pyx_TraceLine(407,0,__PYX_ERR(0, 407, __pyx_L1_error))
  __Pyx_INCREF(__pyx_v_ctrl_d_s);
  __Pyx_GIVEREF(__pyx_v_ctrl_d_s);
  __Pyx_GOTREF(__pyx_v_self->ctrl_d_s);
  __Pyx_DECREF(__pyx_v_self->ctrl_d_s);
  __pyx_v_self->ctrl_d_s = __pyx_v_ctrl_d_s;

  /* "MACS2/IO/CallPeakUnit.pyx":408
 *         self.d = d              # note, self.d doesn't make sense in PE mode
 *         self.ctrl_d_s = ctrl_d_s# note, self.d doesn't make sense in PE mode
 *         self.treat_scaling_factor = treat_scaling_factor             # <<<<<<<<<<<<<<
 *         self.ctrl_scaling_factor_s= ctrl_scaling_factor_s
 *         self.end_shift = end_shift
 */
  __Pyx_TraceLine(408,0,__PYX_ERR(0, 408, __pyx_L1_error))
  __pyx_v_self->treat_scaling_factor = __pyx_v_treat_scaling_factor;

  /* "MACS2/IO/CallPeakUnit.pyx":409
 *         self.ctrl_d_s = ctrl_d_s# note, self.d doesn't make sense in PE mode
 *         self.treat_scaling_factor = treat_scaling_factor
 *         self.ctrl_scaling_factor_s= ctrl_scaling_factor_s             # <<<<<<<<<<<<<<
 *         self.end_shift = end_shift
 *         self.lambda_bg = lambda_bg
 */
  __Pyx_TraceLine(409,0,__PYX_ERR(0, 409, __pyx_L1_error))
  __Pyx_INCREF(__pyx_v_ctrl_scaling_factor_s);
  __Pyx_GIVEREF(__pyx_v_ctrl_scaling_factor_s);
  __Pyx_GOTREF(__pyx_v_self->ctrl_scaling_factor_s);
  __Pyx_DECREF(__pyx_v_self->ctrl_scaling_factor_s);
  __pyx_v_self->ctrl_scaling_factor_s = __pyx_v_ctrl_scaling_factor_s;

  /* "MACS2/IO/CallPeakUnit.pyx":410
 *         self.treat_scaling_factor = treat_scaling_factor
 *         self.ctrl_scaling_factor_s= ctrl_scaling_factor_s
 *         self.end_shift = end_shift             # <<<<<<<<<<<<<<
 *         self.lambda_bg = lambda_bg
 *         self.pqtable = None
 */
  __Pyx_TraceLine(410,0,__PYX_ERR(0, 410, __pyx_L1_error))
  __pyx_v_self->end_shift = __pyx_v_end_shift;

  /* "MACS2/IO/CallPeakUnit.pyx":411
 *         self.ctrl_scaling_factor_s= ctrl_scaling_factor_s
 *         self.end_shift = end_shift
 *         self.lambda_bg = lambda_bg             # <<<<<<<<<<<<<<
 *         self.pqtable = None
 *         self.save_bedGraph = save_bedGraph
 */
  __Pyx_TraceLine(411,0,__PYX_ERR(0, 411, __pyx_L1_error))
  __pyx_v_self->lambda_bg = __pyx_v_lambda_bg;

  /* "MACS2/IO/CallPeakUnit.pyx":412
 *         self.end_shift = end_shift
 *         self.lambda_bg = lambda_bg
 *         self.pqtable = None             # <<<<<<<<<<<<<<
 *         self.save_bedGraph = save_bedGraph
 *         self.save_SPMR = save_SPMR
 */
  __Pyx_TraceLine(412,0,__PYX_ERR(0, 412, __pyx_L1_error))
  __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(Py_None);
  __Pyx_GOTREF(__pyx_v_self->pqtable);
  __Pyx_DECREF(__pyx_v_self->pqtable);
  __pyx_v_self->pqtable = ((PyObject*)Py_None);

  /* "MACS2/IO/CallPeakUnit.pyx":413
 *         self.lambda_bg = lambda_bg
 *         self.pqtable = None
 *         self.save_bedGraph = save_bedGraph             # <<<<<<<<<<<<<<
 *         self.save_SPMR = save_SPMR
 *         self.bedGraph_filename_prefix =  bedGraph_filename_prefix.encode()
 */
  __Pyx_TraceLine(413,0,__PYX_ERR(0, 413, __pyx_L1_error))
  __Pyx_INCREF(((PyObject *)__pyx_v_save_bedGraph));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_save_bedGraph));
  __Pyx_GOTREF(__pyx_v_self->save_bedGraph);
  __Pyx_DECREF(((PyObject *)__pyx_v_self->save_bedGraph));
  __pyx_v_self->save_bedGraph = __pyx_v_save_bedGraph;

  /* "MACS2/IO/CallPeakUnit.pyx":414
 *         self.pqtable = None
 *         self.save_bedGraph = save_bedGraph
 *         self.save_SPMR = save_SPMR             # <<<<<<<<<<<<<<
 *         self.bedGraph_filename_prefix =  bedGraph_filename_prefix.encode()
 *         #tmp_bytes = bedGraph_treat_filename.encode('UTF-8')
 */
  __Pyx_TraceLine(414,0,__PYX_ERR(0, 414, __pyx_L1_error))
  __Pyx_INCREF(((PyObject *)__pyx_v_save_SPMR));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_save_SPMR));
  __Pyx_GOTREF(__pyx_v_self->save_SPMR);
  __Pyx_DECREF(((PyObject *)__pyx_v_self->save_SPMR));
  __pyx_v_self->save_SPMR = __pyx_v_save_SPMR;

  /* "MACS2/IO/CallPeakUnit.pyx":415
 *         self.save_bedGraph = save_bedGraph
 *         self.save_SPMR = save_SPMR
 *         self.bedGraph_filename_prefix =  bedGraph_filename_prefix.encode()             # <<<<<<<<<<<<<<
 *         #tmp_bytes = bedGraph_treat_filename.encode('UTF-8')
 *         #print bedGraph_treat_filename, tmp_bytes
 */
  __Pyx_TraceLine(415,0,__PYX_ERR(0, 415, __pyx_L1_error))
  if (unlikely(__pyx_v_bedGraph_filename_prefix == Py_None)) {
    PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "encode");
    __PYX_ERR(0, 415, __pyx_L1_error)
  }
  __pyx_t_1 = PyUnicode_AsEncodedString(__pyx_v_bedGraph_filename_prefix, NULL, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 415, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v_self->bedGraph_filename_prefix);
  __Pyx_DECREF(__pyx_v_self->bedGraph_filename_prefix);
  __pyx_v_self->bedGraph_filename_prefix = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":418
 *         #tmp_bytes = bedGraph_treat_filename.encode('UTF-8')
 *         #print bedGraph_treat_filename, tmp_bytes
 *         self.bedGraph_treat_filename = bedGraph_treat_filename.encode()             # <<<<<<<<<<<<<<
 *         #tmp_bytes = bedGraph_control_filename.encode('UTF-8')
 *         #print bedGraph_control_filename, tmp_bytes
 */
  __Pyx_TraceLine(418,0,__PYX_ERR(0, 418, __pyx_L1_error))
  if (unlikely(__pyx_v_bedGraph_treat_filename == Py_None)) {
    PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "encode");
    __PYX_ERR(0, 418, __pyx_L1_error)
  }
  __pyx_t_1 = PyUnicode_AsEncodedString(__pyx_v_bedGraph_treat_filename, NULL, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 418, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v_self->bedGraph_treat_filename);
  __Pyx_DECREF(__pyx_v_self->bedGraph_treat_filename);
  __pyx_v_self->bedGraph_treat_filename = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":421
 *         #tmp_bytes = bedGraph_control_filename.encode('UTF-8')
 *         #print bedGraph_control_filename, tmp_bytes
 *         self.bedGraph_control_filename = bedGraph_control_filename.encode()             # <<<<<<<<<<<<<<
 * 
 *         #print  ">>", self.bedGraph_treat_filename
 */
  __Pyx_TraceLine(421,0,__PYX_ERR(0, 421, __pyx_L1_error))
  if (unlikely(__pyx_v_bedGraph_control_filename == Py_None)) {
    PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "encode");
    __PYX_ERR(0, 421, __pyx_L1_error)
  }
  __pyx_t_1 = PyUnicode_AsEncodedString(__pyx_v_bedGraph_control_filename, NULL, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 421, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v_self->bedGraph_control_filename);
  __Pyx_DECREF(__pyx_v_self->bedGraph_control_filename);
  __pyx_v_self->bedGraph_control_filename = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":426
 *         #print  ">>", self.bedGraph_control_filename
 * 
 *         if not self.ctrl_d_s or not self.ctrl_scaling_factor_s:             # <<<<<<<<<<<<<<
 *             self.no_lambda_flag = True
 *         else:
 */
  __Pyx_TraceLine(426,0,__PYX_ERR(0, 426, __pyx_L1_error))
  __pyx_t_3 = (__pyx_v_self->ctrl_d_s != Py_None)&&(PyList_GET_SIZE(__pyx_v_self->ctrl_d_s) != 0);
  __pyx_t_4 = ((!__pyx_t_3) != 0);
  if (!__pyx_t_4) {
  } else {
    __pyx_t_2 = __pyx_t_4;
    goto __pyx_L6_bool_binop_done;
  }
  __pyx_t_4 = (__pyx_v_self->ctrl_scaling_factor_s != Py_None)&&(PyList_GET_SIZE(__pyx_v_self->ctrl_scaling_factor_s) != 0);
  __pyx_t_3 = ((!__pyx_t_4) != 0);
  __pyx_t_2 = __pyx_t_3;
  __pyx_L6_bool_binop_done:;
  if (__pyx_t_2) {

    /* "MACS2/IO/CallPeakUnit.pyx":427
 * 
 *         if not self.ctrl_d_s or not self.ctrl_scaling_factor_s:
 *             self.no_lambda_flag = True             # <<<<<<<<<<<<<<
 *         else:
 *             self.no_lambda_flag = False
 */
    __Pyx_TraceLine(427,0,__PYX_ERR(0, 427, __pyx_L1_error))
    __Pyx_INCREF(Py_True);
    __Pyx_GIVEREF(Py_True);
    __Pyx_GOTREF(__pyx_v_self->no_lambda_flag);
    __Pyx_DECREF(((PyObject *)__pyx_v_self->no_lambda_flag));
    __pyx_v_self->no_lambda_flag = ((PyBoolObject *)Py_True);

    /* "MACS2/IO/CallPeakUnit.pyx":426
 *         #print  ">>", self.bedGraph_control_filename
 * 
 *         if not self.ctrl_d_s or not self.ctrl_scaling_factor_s:             # <<<<<<<<<<<<<<
 *             self.no_lambda_flag = True
 *         else:
 */
    goto __pyx_L5;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":429
 *             self.no_lambda_flag = True
 *         else:
 *             self.no_lambda_flag = False             # <<<<<<<<<<<<<<
 * 
 *         self.pseudocount = pseudocount
 */
  __Pyx_TraceLine(429,0,__PYX_ERR(0, 429, __pyx_L1_error))
  /*else*/ {
    __Pyx_INCREF(Py_False);
    __Pyx_GIVEREF(Py_False);
    __Pyx_GOTREF(__pyx_v_self->no_lambda_flag);
    __Pyx_DECREF(((PyObject *)__pyx_v_self->no_lambda_flag));
    __pyx_v_self->no_lambda_flag = ((PyBoolObject *)Py_False);
  }
  __pyx_L5:;

  /* "MACS2/IO/CallPeakUnit.pyx":431
 *             self.no_lambda_flag = False
 * 
 *         self.pseudocount = pseudocount             # <<<<<<<<<<<<<<
 * 
 *         chr1 = set(self.treat.get_chr_names())
 */
  __Pyx_TraceLine(431,0,__PYX_ERR(0, 431, __pyx_L1_error))
  __pyx_v_self->pseudocount = __pyx_v_pseudocount;

  /* "MACS2/IO/CallPeakUnit.pyx":433
 *         self.pseudocount = pseudocount
 * 
 *         chr1 = set(self.treat.get_chr_names())             # <<<<<<<<<<<<<<
 *         chr2 = set(self.ctrl.get_chr_names())
 *         self.chromosomes = sorted(list(chr1.intersection(chr2)))
 */
  __Pyx_TraceLine(433,0,__PYX_ERR(0, 433, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_get_chr_names); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 433, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_1 = (__pyx_t_6) ? __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_6) : __Pyx_PyObject_CallNoArg(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 433, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = PySet_New(__pyx_t_1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 433, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_v_chr1 = ((PyObject*)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":434
 * 
 *         chr1 = set(self.treat.get_chr_names())
 *         chr2 = set(self.ctrl.get_chr_names())             # <<<<<<<<<<<<<<
 *         self.chromosomes = sorted(list(chr1.intersection(chr2)))
 * 
 */
  __Pyx_TraceLine(434,0,__PYX_ERR(0, 434, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->ctrl, __pyx_n_s_get_chr_names); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 434, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_1))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_1);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_1);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_1, function);
    }
  }
  __pyx_t_5 = (__pyx_t_6) ? __Pyx_PyObject_CallOneArg(__pyx_t_1, __pyx_t_6) : __Pyx_PyObject_CallNoArg(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 434, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PySet_New(__pyx_t_5); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 434, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_v_chr2 = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":435
 *         chr1 = set(self.treat.get_chr_names())
 *         chr2 = set(self.ctrl.get_chr_names())
 *         self.chromosomes = sorted(list(chr1.intersection(chr2)))             # <<<<<<<<<<<<<<
 * 
 *         self.test_time = 0
 */
  __Pyx_TraceLine(435,0,__PYX_ERR(0, 435, __pyx_L1_error))
  __pyx_t_5 = __Pyx_CallUnboundCMethod1(&__pyx_umethod_PySet_Type_intersection, __pyx_v_chr1, __pyx_v_chr2); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 435, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = PySequence_List(__pyx_t_5); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 435, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = PySequence_List(__pyx_t_6); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 435, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_1 = ((PyObject*)__pyx_t_5);
  __pyx_t_5 = 0;
  __pyx_t_7 = PyList_Sort(__pyx_t_1); if (unlikely(__pyx_t_7 == ((int)-1))) __PYX_ERR(0, 435, __pyx_L1_error)
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v_self->chromosomes);
  __Pyx_DECREF(__pyx_v_self->chromosomes);
  __pyx_v_self->chromosomes = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":437
 *         self.chromosomes = sorted(list(chr1.intersection(chr2)))
 * 
 *         self.test_time = 0             # <<<<<<<<<<<<<<
 *         self.pileup_data_files = {}
 * 
 */
  __Pyx_TraceLine(437,0,__PYX_ERR(0, 437, __pyx_L1_error))
  __pyx_v_self->test_time = 0.0;

  /* "MACS2/IO/CallPeakUnit.pyx":438
 * 
 *         self.test_time = 0
 *         self.pileup_data_files = {}             # <<<<<<<<<<<<<<
 * 
 *         self.pvalue_length = {}
 */
  __Pyx_TraceLine(438,0,__PYX_ERR(0, 438, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 438, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v_self->pileup_data_files);
  __Pyx_DECREF(__pyx_v_self->pileup_data_files);
  __pyx_v_self->pileup_data_files = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":440
 *         self.pileup_data_files = {}
 * 
 *         self.pvalue_length = {}             # <<<<<<<<<<<<<<
 *         self.pvalue_npeaks = {}
 *         for p in np.arange( 0.3, 10, 0.3 ): # step for optimal cutoff is 0.3 in -log10pvalue, we try from pvalue 1E-10 (-10logp=10) to 0.5 (-10logp=0.3)
 */
  __Pyx_TraceLine(440,0,__PYX_ERR(0, 440, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 440, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v_self->pvalue_length);
  __Pyx_DECREF(__pyx_v_self->pvalue_length);
  __pyx_v_self->pvalue_length = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":441
 * 
 *         self.pvalue_length = {}
 *         self.pvalue_npeaks = {}             # <<<<<<<<<<<<<<
 *         for p in np.arange( 0.3, 10, 0.3 ): # step for optimal cutoff is 0.3 in -log10pvalue, we try from pvalue 1E-10 (-10logp=10) to 0.5 (-10logp=0.3)
 *             self.pvalue_length[ p ] = 0
 */
  __Pyx_TraceLine(441,0,__PYX_ERR(0, 441, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 441, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_GIVEREF(__pyx_t_1);
  __Pyx_GOTREF(__pyx_v_self->pvalue_npeaks);
  __Pyx_DECREF(__pyx_v_self->pvalue_npeaks);
  __pyx_v_self->pvalue_npeaks = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":442
 *         self.pvalue_length = {}
 *         self.pvalue_npeaks = {}
 *         for p in np.arange( 0.3, 10, 0.3 ): # step for optimal cutoff is 0.3 in -log10pvalue, we try from pvalue 1E-10 (-10logp=10) to 0.5 (-10logp=0.3)             # <<<<<<<<<<<<<<
 *             self.pvalue_length[ p ] = 0
 *             self.pvalue_npeaks[ p ] = 0
 */
  __Pyx_TraceLine(442,0,__PYX_ERR(0, 442, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 442, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_arange); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 442, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_5, __pyx_tuple__6, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 442, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (likely(PyList_CheckExact(__pyx_t_1)) || PyTuple_CheckExact(__pyx_t_1)) {
    __pyx_t_5 = __pyx_t_1; __Pyx_INCREF(__pyx_t_5); __pyx_t_8 = 0;
    __pyx_t_9 = NULL;
  } else {
    __pyx_t_8 = -1; __pyx_t_5 = PyObject_GetIter(__pyx_t_1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 442, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_9 = Py_TYPE(__pyx_t_5)->tp_iternext; if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 442, __pyx_L1_error)
  }
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  for (;;) {
    if (likely(!__pyx_t_9)) {
      if (likely(PyList_CheckExact(__pyx_t_5))) {
        if (__pyx_t_8 >= PyList_GET_SIZE(__pyx_t_5)) break;
        #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
        __pyx_t_1 = PyList_GET_ITEM(__pyx_t_5, __pyx_t_8); __Pyx_INCREF(__pyx_t_1); __pyx_t_8++; if (unlikely(0 < 0)) __PYX_ERR(0, 442, __pyx_L1_error)
        #else
        __pyx_t_1 = PySequence_ITEM(__pyx_t_5, __pyx_t_8); __pyx_t_8++; if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 442, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        #endif
      } else {
        if (__pyx_t_8 >= PyTuple_GET_SIZE(__pyx_t_5)) break;
        #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
        __pyx_t_1 = PyTuple_GET_ITEM(__pyx_t_5, __pyx_t_8); __Pyx_INCREF(__pyx_t_1); __pyx_t_8++; if (unlikely(0 < 0)) __PYX_ERR(0, 442, __pyx_L1_error)
        #else
        __pyx_t_1 = PySequence_ITEM(__pyx_t_5, __pyx_t_8); __pyx_t_8++; if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 442, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        #endif
      }
    } else {
      __pyx_t_1 = __pyx_t_9(__pyx_t_5);
      if (unlikely(!__pyx_t_1)) {
        PyObject* exc_type = PyErr_Occurred();
        if (exc_type) {
          if (likely(__Pyx_PyErr_GivenExceptionMatches(exc_type, PyExc_StopIteration))) PyErr_Clear();
          else __PYX_ERR(0, 442, __pyx_L1_error)
        }
        break;
      }
      __Pyx_GOTREF(__pyx_t_1);
    }
    __pyx_t_10 = __pyx_PyFloat_AsFloat(__pyx_t_1); if (unlikely((__pyx_t_10 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 442, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_p = __pyx_t_10;

    /* "MACS2/IO/CallPeakUnit.pyx":443
 *         self.pvalue_npeaks = {}
 *         for p in np.arange( 0.3, 10, 0.3 ): # step for optimal cutoff is 0.3 in -log10pvalue, we try from pvalue 1E-10 (-10logp=10) to 0.5 (-10logp=0.3)
 *             self.pvalue_length[ p ] = 0             # <<<<<<<<<<<<<<
 *             self.pvalue_npeaks[ p ] = 0
 *         self.optimal_p_cutoff = 0
 */
    __Pyx_TraceLine(443,0,__PYX_ERR(0, 443, __pyx_L1_error))
    if (unlikely(__pyx_v_self->pvalue_length == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 443, __pyx_L1_error)
    }
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_p); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 443, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (unlikely(PyDict_SetItem(__pyx_v_self->pvalue_length, __pyx_t_1, __pyx_int_0) < 0)) __PYX_ERR(0, 443, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":444
 *         for p in np.arange( 0.3, 10, 0.3 ): # step for optimal cutoff is 0.3 in -log10pvalue, we try from pvalue 1E-10 (-10logp=10) to 0.5 (-10logp=0.3)
 *             self.pvalue_length[ p ] = 0
 *             self.pvalue_npeaks[ p ] = 0             # <<<<<<<<<<<<<<
 *         self.optimal_p_cutoff = 0
 *         self.cutoff_analysis_filename = cutoff_analysis_filename.encode()
 */
    __Pyx_TraceLine(444,0,__PYX_ERR(0, 444, __pyx_L1_error))
    if (unlikely(__pyx_v_self->pvalue_npeaks == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 444, __pyx_L1_error)
    }
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_p); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 444, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (unlikely(PyDict_SetItem(__pyx_v_self->pvalue_npeaks, __pyx_t_1, __pyx_int_0) < 0)) __PYX_ERR(0, 444, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":442
 *         self.pvalue_length = {}
 *         self.pvalue_npeaks = {}
 *         for p in np.arange( 0.3, 10, 0.3 ): # step for optimal cutoff is 0.3 in -log10pvalue, we try from pvalue 1E-10 (-10logp=10) to 0.5 (-10logp=0.3)             # <<<<<<<<<<<<<<
 *             self.pvalue_length[ p ] = 0
 *             self.pvalue_npeaks[ p ] = 0
 */
    __Pyx_TraceLine(442,0,__PYX_ERR(0, 442, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":445
 *             self.pvalue_length[ p ] = 0
 *             self.pvalue_npeaks[ p ] = 0
 *         self.optimal_p_cutoff = 0             # <<<<<<<<<<<<<<
 *         self.cutoff_analysis_filename = cutoff_analysis_filename.encode()
 * 
 */
  __Pyx_TraceLine(445,0,__PYX_ERR(0, 445, __pyx_L1_error))
  __pyx_v_self->optimal_p_cutoff = 0.0;

  /* "MACS2/IO/CallPeakUnit.pyx":446
 *             self.pvalue_npeaks[ p ] = 0
 *         self.optimal_p_cutoff = 0
 *         self.cutoff_analysis_filename = cutoff_analysis_filename.encode()             # <<<<<<<<<<<<<<
 * 
 *     cpdef destroy ( self ):
 */
  __Pyx_TraceLine(446,0,__PYX_ERR(0, 446, __pyx_L1_error))
  if (unlikely(__pyx_v_cutoff_analysis_filename == Py_None)) {
    PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "encode");
    __PYX_ERR(0, 446, __pyx_L1_error)
  }
  __pyx_t_5 = PyUnicode_AsEncodedString(__pyx_v_cutoff_analysis_filename, NULL, NULL); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 446, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_GIVEREF(__pyx_t_5);
  __Pyx_GOTREF(__pyx_v_self->cutoff_analysis_filename);
  __Pyx_DECREF(__pyx_v_self->cutoff_analysis_filename);
  __pyx_v_self->cutoff_analysis_filename = ((PyObject*)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":344
 * 
 * 
 *     def __init__ (self, treat, ctrl,             # <<<<<<<<<<<<<<
 *                   int32_t d = 200, list ctrl_d_s = [200, 1000, 10000],
 *                   float32_t treat_scaling_factor = 1.0, list ctrl_scaling_factor_s = [1.0, 0.2, 0.02],
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__init__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_chr1);
  __Pyx_XDECREF(__pyx_v_chr2);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":448
 *         self.cutoff_analysis_filename = cutoff_analysis_filename.encode()
 * 
 *     cpdef destroy ( self ):             # <<<<<<<<<<<<<<
 *         """Remove temparary files for pileup values of each chromosome.
 * 
 */

static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_3destroy(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused); /*proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_destroy(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, int __pyx_skip_dispatch) {
  PyObject *__pyx_v_f = 0;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  Py_ssize_t __pyx_t_5;
  Py_ssize_t __pyx_t_6;
  int __pyx_t_7;
  int __pyx_t_8;
  int __pyx_t_9;
  __Pyx_RefNannySetupContext("destroy", 0);
  __Pyx_TraceCall("destroy", __pyx_f[0], 448, 0, __PYX_ERR(0, 448, __pyx_L1_error));
  /* Check if called by wrapper */
  if (unlikely(__pyx_skip_dispatch)) ;
  /* Check if overridden in Python */
  else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || (Py_TYPE(((PyObject *)__pyx_v_self))->tp_flags & (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
    #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
    if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
      PY_UINT64_T __pyx_type_dict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      #endif
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_destroy); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 448, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (!PyCFunction_Check(__pyx_t_1) || (PyCFunction_GET_FUNCTION(__pyx_t_1) != (PyCFunction)(void*)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_3destroy)) {
        __Pyx_XDECREF(__pyx_r);
        __Pyx_INCREF(__pyx_t_1);
        __pyx_t_3 = __pyx_t_1; __pyx_t_4 = NULL;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
          __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
          if (likely(__pyx_t_4)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
            __Pyx_INCREF(__pyx_t_4);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_3, function);
          }
        }
        __pyx_t_2 = (__pyx_t_4) ? __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_t_4) : __Pyx_PyObject_CallNoArg(__pyx_t_3);
        __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
        if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 448, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __pyx_r = __pyx_t_2;
        __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        goto __pyx_L0;
      }
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
      __pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      __pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
      if (unlikely(__pyx_type_dict_guard != __pyx_tp_dict_version)) {
        __pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
      }
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    }
    #endif
  }

  /* "MACS2/IO/CallPeakUnit.pyx":458
 *             bytes f
 * 
 *         for f in self.pileup_data_files.values():             # <<<<<<<<<<<<<<
 *             if os.path.isfile( f ):
 *                 os.unlink( f )
 */
  __Pyx_TraceLine(458,0,__PYX_ERR(0, 458, __pyx_L1_error))
  __pyx_t_5 = 0;
  if (unlikely(__pyx_v_self->pileup_data_files == Py_None)) {
    PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "values");
    __PYX_ERR(0, 458, __pyx_L1_error)
  }
  __pyx_t_2 = __Pyx_dict_iterator(__pyx_v_self->pileup_data_files, 1, __pyx_n_s_values, (&__pyx_t_6), (&__pyx_t_7)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 458, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_1);
  __pyx_t_1 = __pyx_t_2;
  __pyx_t_2 = 0;
  while (1) {
    __pyx_t_8 = __Pyx_dict_iter_next(__pyx_t_1, __pyx_t_6, &__pyx_t_5, NULL, &__pyx_t_2, NULL, __pyx_t_7);
    if (unlikely(__pyx_t_8 == 0)) break;
    if (unlikely(__pyx_t_8 == -1)) __PYX_ERR(0, 458, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    if (!(likely(PyBytes_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_2)->tp_name), 0))) __PYX_ERR(0, 458, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_f, ((PyObject*)__pyx_t_2));
    __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":459
 * 
 *         for f in self.pileup_data_files.values():
 *             if os.path.isfile( f ):             # <<<<<<<<<<<<<<
 *                 os.unlink( f )
 *         return
 */
    __Pyx_TraceLine(459,0,__PYX_ERR(0, 459, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_os); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 459, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_path); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 459, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_isfile); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 459, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_4 = NULL;
    if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_3))) {
      __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
      if (likely(__pyx_t_4)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
        __Pyx_INCREF(__pyx_t_4);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_3, function);
      }
    }
    __pyx_t_2 = (__pyx_t_4) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_4, __pyx_v_f) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_v_f);
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 459, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_9 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_9 < 0)) __PYX_ERR(0, 459, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (__pyx_t_9) {

      /* "MACS2/IO/CallPeakUnit.pyx":460
 *         for f in self.pileup_data_files.values():
 *             if os.path.isfile( f ):
 *                 os.unlink( f )             # <<<<<<<<<<<<<<
 *         return
 * 
 */
      __Pyx_TraceLine(460,0,__PYX_ERR(0, 460, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_os); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 460, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_unlink); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 460, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_3 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_4))) {
        __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_4);
        if (likely(__pyx_t_3)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
          __Pyx_INCREF(__pyx_t_3);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_4, function);
        }
      }
      __pyx_t_2 = (__pyx_t_3) ? __Pyx_PyObject_Call2Args(__pyx_t_4, __pyx_t_3, __pyx_v_f) : __Pyx_PyObject_CallOneArg(__pyx_t_4, __pyx_v_f);
      __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 460, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":459
 * 
 *         for f in self.pileup_data_files.values():
 *             if os.path.isfile( f ):             # <<<<<<<<<<<<<<
 *                 os.unlink( f )
 *         return
 */
    }
  }
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":461
 *             if os.path.isfile( f ):
 *                 os.unlink( f )
 *         return             # <<<<<<<<<<<<<<
 * 
 *     cpdef set_pseudocount( self, float32_t pseudocount ):
 */
  __Pyx_TraceLine(461,0,__PYX_ERR(0, 461, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":448
 *         self.cutoff_analysis_filename = cutoff_analysis_filename.encode()
 * 
 *     cpdef destroy ( self ):             # <<<<<<<<<<<<<<
 *         """Remove temparary files for pileup values of each chromosome.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.destroy", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_f);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_3destroy(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused); /*proto*/
static char __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_2destroy[] = "Remove temparary files for pileup values of each chromosome.\n\n        Note: This function MUST be called if the class object won't\n        be used anymore.\n\n        ";
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_3destroy(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused) {
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("destroy (wrapper)", 0);
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_2destroy(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_2destroy(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("destroy", 0);
  __Pyx_TraceCall("destroy (wrapper)", __pyx_f[0], 448, 0, __PYX_ERR(0, 448, __pyx_L1_error));
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_destroy(__pyx_v_self, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 448, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.destroy", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":463
 *         return
 * 
 *     cpdef set_pseudocount( self, float32_t pseudocount ):             # <<<<<<<<<<<<<<
 *         self.pseudocount = pseudocount
 * 
 */

static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_5set_pseudocount(PyObject *__pyx_v_self, PyObject *__pyx_arg_pseudocount); /*proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_set_pseudocount(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, __pyx_t_5numpy_float32_t __pyx_v_pseudocount, int __pyx_skip_dispatch) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  __Pyx_RefNannySetupContext("set_pseudocount", 0);
  __Pyx_TraceCall("set_pseudocount", __pyx_f[0], 463, 0, __PYX_ERR(0, 463, __pyx_L1_error));
  /* Check if called by wrapper */
  if (unlikely(__pyx_skip_dispatch)) ;
  /* Check if overridden in Python */
  else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || (Py_TYPE(((PyObject *)__pyx_v_self))->tp_flags & (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
    #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
    if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
      PY_UINT64_T __pyx_type_dict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      #endif
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_set_pseudocount); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 463, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (!PyCFunction_Check(__pyx_t_1) || (PyCFunction_GET_FUNCTION(__pyx_t_1) != (PyCFunction)(void*)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_5set_pseudocount)) {
        __Pyx_XDECREF(__pyx_r);
        __pyx_t_3 = PyFloat_FromDouble(__pyx_v_pseudocount); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 463, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __Pyx_INCREF(__pyx_t_1);
        __pyx_t_4 = __pyx_t_1; __pyx_t_5 = NULL;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_4))) {
          __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_4);
          if (likely(__pyx_t_5)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
            __Pyx_INCREF(__pyx_t_5);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_4, function);
          }
        }
        __pyx_t_2 = (__pyx_t_5) ? __Pyx_PyObject_Call2Args(__pyx_t_4, __pyx_t_5, __pyx_t_3) : __Pyx_PyObject_CallOneArg(__pyx_t_4, __pyx_t_3);
        __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 463, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        __pyx_r = __pyx_t_2;
        __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        goto __pyx_L0;
      }
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
      __pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      __pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
      if (unlikely(__pyx_type_dict_guard != __pyx_tp_dict_version)) {
        __pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
      }
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    }
    #endif
  }

  /* "MACS2/IO/CallPeakUnit.pyx":464
 * 
 *     cpdef set_pseudocount( self, float32_t pseudocount ):
 *         self.pseudocount = pseudocount             # <<<<<<<<<<<<<<
 * 
 *     cpdef enable_trackline( self ):
 */
  __Pyx_TraceLine(464,0,__PYX_ERR(0, 464, __pyx_L1_error))
  __pyx_v_self->pseudocount = __pyx_v_pseudocount;

  /* "MACS2/IO/CallPeakUnit.pyx":463
 *         return
 * 
 *     cpdef set_pseudocount( self, float32_t pseudocount ):             # <<<<<<<<<<<<<<
 *         self.pseudocount = pseudocount
 * 
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.set_pseudocount", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_5set_pseudocount(PyObject *__pyx_v_self, PyObject *__pyx_arg_pseudocount); /*proto*/
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_5set_pseudocount(PyObject *__pyx_v_self, PyObject *__pyx_arg_pseudocount) {
  __pyx_t_5numpy_float32_t __pyx_v_pseudocount;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("set_pseudocount (wrapper)", 0);
  assert(__pyx_arg_pseudocount); {
    __pyx_v_pseudocount = __pyx_PyFloat_AsFloat(__pyx_arg_pseudocount); if (unlikely((__pyx_v_pseudocount == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 463, __pyx_L3_error)
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L3_error:;
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.set_pseudocount", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_4set_pseudocount(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self), ((__pyx_t_5numpy_float32_t)__pyx_v_pseudocount));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_4set_pseudocount(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, __pyx_t_5numpy_float32_t __pyx_v_pseudocount) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("set_pseudocount", 0);
  __Pyx_TraceCall("set_pseudocount (wrapper)", __pyx_f[0], 463, 0, __PYX_ERR(0, 463, __pyx_L1_error));
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_set_pseudocount(__pyx_v_self, __pyx_v_pseudocount, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 463, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.set_pseudocount", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":466
 *         self.pseudocount = pseudocount
 * 
 *     cpdef enable_trackline( self ):             # <<<<<<<<<<<<<<
 *         """Turn on trackline with bedgraph output
 *         """
 */

static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_7enable_trackline(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused); /*proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_enable_trackline(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, int __pyx_skip_dispatch) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  __Pyx_RefNannySetupContext("enable_trackline", 0);
  __Pyx_TraceCall("enable_trackline", __pyx_f[0], 466, 0, __PYX_ERR(0, 466, __pyx_L1_error));
  /* Check if called by wrapper */
  if (unlikely(__pyx_skip_dispatch)) ;
  /* Check if overridden in Python */
  else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || (Py_TYPE(((PyObject *)__pyx_v_self))->tp_flags & (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
    #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
    if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
      PY_UINT64_T __pyx_type_dict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      #endif
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_enable_trackline); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 466, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (!PyCFunction_Check(__pyx_t_1) || (PyCFunction_GET_FUNCTION(__pyx_t_1) != (PyCFunction)(void*)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_7enable_trackline)) {
        __Pyx_XDECREF(__pyx_r);
        __Pyx_INCREF(__pyx_t_1);
        __pyx_t_3 = __pyx_t_1; __pyx_t_4 = NULL;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
          __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
          if (likely(__pyx_t_4)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
            __Pyx_INCREF(__pyx_t_4);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_3, function);
          }
        }
        __pyx_t_2 = (__pyx_t_4) ? __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_t_4) : __Pyx_PyObject_CallNoArg(__pyx_t_3);
        __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
        if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 466, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __pyx_r = __pyx_t_2;
        __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        goto __pyx_L0;
      }
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
      __pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      __pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
      if (unlikely(__pyx_type_dict_guard != __pyx_tp_dict_version)) {
        __pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
      }
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    }
    #endif
  }

  /* "MACS2/IO/CallPeakUnit.pyx":469
 *         """Turn on trackline with bedgraph output
 *         """
 *         self.trackline = True             # <<<<<<<<<<<<<<
 * 
 *     cdef __pileup_treat_ctrl_a_chromosome ( self, bytes chrom ):
 */
  __Pyx_TraceLine(469,0,__PYX_ERR(0, 469, __pyx_L1_error))
  __Pyx_INCREF(Py_True);
  __Pyx_GIVEREF(Py_True);
  __Pyx_GOTREF(__pyx_v_self->trackline);
  __Pyx_DECREF(((PyObject *)__pyx_v_self->trackline));
  __pyx_v_self->trackline = ((PyBoolObject *)Py_True);

  /* "MACS2/IO/CallPeakUnit.pyx":466
 *         self.pseudocount = pseudocount
 * 
 *     cpdef enable_trackline( self ):             # <<<<<<<<<<<<<<
 *         """Turn on trackline with bedgraph output
 *         """
 */

  /* function exit code */
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.enable_trackline", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_7enable_trackline(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused); /*proto*/
static char __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_6enable_trackline[] = "Turn on trackline with bedgraph output\n        ";
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_7enable_trackline(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused) {
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("enable_trackline (wrapper)", 0);
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_6enable_trackline(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_6enable_trackline(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("enable_trackline", 0);
  __Pyx_TraceCall("enable_trackline (wrapper)", __pyx_f[0], 466, 0, __PYX_ERR(0, 466, __pyx_L1_error));
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_enable_trackline(__pyx_v_self, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 466, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.enable_trackline", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":471
 *         self.trackline = True
 * 
 *     cdef __pileup_treat_ctrl_a_chromosome ( self, bytes chrom ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.chr_pos_treat_ctrl will
 *         be reset and assigned to the pileup values of the given
 */

static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pileup_treat_ctrl_a_chromosome(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_chrom) {
  PyObject *__pyx_v_treat_pv = 0;
  PyObject *__pyx_v_ctrl_pv = 0;
  PyObject *__pyx_v_f = 0;
  PyObject *__pyx_v_temp_filename = 0;
  PyObject *__pyx_v_temp_fd = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  PyObject *__pyx_t_2 = NULL;
  int __pyx_t_3;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  PyObject *__pyx_t_10 = NULL;
  PyObject *__pyx_t_11 = NULL;
  PyObject *__pyx_t_12 = NULL;
  PyObject *(*__pyx_t_13)(PyObject *);
  __Pyx_RefNannySetupContext("__pileup_treat_ctrl_a_chromosome", 0);
  __Pyx_TraceCall("__pileup_treat_ctrl_a_chromosome", __pyx_f[0], 471, 0, __PYX_ERR(0, 471, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":484
 *             str temp_filename
 * 
 *         assert chrom in self.chromosomes, "chromosome %s is not valid." % chrom             # <<<<<<<<<<<<<<
 * 
 *         # check backup file of pileup values. If not exists, create
 */
  __Pyx_TraceLine(484,0,__PYX_ERR(0, 484, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    __pyx_t_1 = (__Pyx_PySequence_ContainsTF(__pyx_v_chrom, __pyx_v_self->chromosomes, Py_EQ)); if (unlikely(__pyx_t_1 < 0)) __PYX_ERR(0, 484, __pyx_L1_error)
    if (unlikely(!(__pyx_t_1 != 0))) {
      __pyx_t_2 = PyUnicode_Format(__pyx_kp_u_chromosome_s_is_not_valid, __pyx_v_chrom); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 484, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      PyErr_SetObject(PyExc_AssertionError, __pyx_t_2);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __PYX_ERR(0, 484, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":489
 *         # it. Otherwise, load them instead of calculating new pileup
 *         # values.
 *         if chrom in self.pileup_data_files:             # <<<<<<<<<<<<<<
 *             try:
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )
 */
  __Pyx_TraceLine(489,0,__PYX_ERR(0, 489, __pyx_L1_error))
  if (unlikely(__pyx_v_self->pileup_data_files == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
    __PYX_ERR(0, 489, __pyx_L1_error)
  }
  __pyx_t_1 = (__Pyx_PyDict_ContainsTF(__pyx_v_chrom, __pyx_v_self->pileup_data_files, Py_EQ)); if (unlikely(__pyx_t_1 < 0)) __PYX_ERR(0, 489, __pyx_L1_error)
  __pyx_t_3 = (__pyx_t_1 != 0);
  if (__pyx_t_3) {

    /* "MACS2/IO/CallPeakUnit.pyx":490
 *         # values.
 *         if chrom in self.pileup_data_files:
 *             try:             # <<<<<<<<<<<<<<
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )
 *                 self.chr_pos_treat_ctrl = cPickle.load( f )
 */
    __Pyx_TraceLine(490,0,__PYX_ERR(0, 490, __pyx_L1_error))
    {
      __Pyx_PyThreadState_declare
      __Pyx_PyThreadState_assign
      __Pyx_ExceptionSave(&__pyx_t_4, &__pyx_t_5, &__pyx_t_6);
      __Pyx_XGOTREF(__pyx_t_4);
      __Pyx_XGOTREF(__pyx_t_5);
      __Pyx_XGOTREF(__pyx_t_6);
      /*try:*/ {

        /* "MACS2/IO/CallPeakUnit.pyx":491
 *         if chrom in self.pileup_data_files:
 *             try:
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )             # <<<<<<<<<<<<<<
 *                 self.chr_pos_treat_ctrl = cPickle.load( f )
 *                 f.close()
 */
        __Pyx_TraceLine(491,0,__PYX_ERR(0, 491, __pyx_L4_error))
        if (unlikely(__pyx_v_self->pileup_data_files == Py_None)) {
          PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
          __PYX_ERR(0, 491, __pyx_L4_error)
        }
        __pyx_t_2 = __Pyx_PyDict_GetItem(__pyx_v_self->pileup_data_files, __pyx_v_chrom); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 491, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_7 = PyTuple_New(2); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 491, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_7);
        __Pyx_GIVEREF(__pyx_t_2);
        PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_t_2);
        __Pyx_INCREF(__pyx_n_u_rb);
        __Pyx_GIVEREF(__pyx_n_u_rb);
        PyTuple_SET_ITEM(__pyx_t_7, 1, __pyx_n_u_rb);
        __pyx_t_2 = 0;
        __pyx_t_2 = __Pyx_PyObject_Call(__pyx_builtin_open, __pyx_t_7, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 491, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
        __pyx_v_f = __pyx_t_2;
        __pyx_t_2 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":492
 *             try:
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )
 *                 self.chr_pos_treat_ctrl = cPickle.load( f )             # <<<<<<<<<<<<<<
 *                 f.close()
 *                 return
 */
        __Pyx_TraceLine(492,0,__PYX_ERR(0, 492, __pyx_L4_error))
        __Pyx_GetModuleGlobalName(__pyx_t_7, __pyx_n_s_cPickle); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 492, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_7);
        __pyx_t_8 = __Pyx_PyObject_GetAttrStr(__pyx_t_7, __pyx_n_s_load); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 492, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_8);
        __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
        __pyx_t_7 = NULL;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_8))) {
          __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_8);
          if (likely(__pyx_t_7)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_8);
            __Pyx_INCREF(__pyx_t_7);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_8, function);
          }
        }
        __pyx_t_2 = (__pyx_t_7) ? __Pyx_PyObject_Call2Args(__pyx_t_8, __pyx_t_7, __pyx_v_f) : __Pyx_PyObject_CallOneArg(__pyx_t_8, __pyx_v_f);
        __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
        if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 492, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        if (!(likely(PyList_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_2)->tp_name), 0))) __PYX_ERR(0, 492, __pyx_L4_error)
        __Pyx_GIVEREF(__pyx_t_2);
        __Pyx_GOTREF(__pyx_v_self->chr_pos_treat_ctrl);
        __Pyx_DECREF(__pyx_v_self->chr_pos_treat_ctrl);
        __pyx_v_self->chr_pos_treat_ctrl = ((PyObject*)__pyx_t_2);
        __pyx_t_2 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":493
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )
 *                 self.chr_pos_treat_ctrl = cPickle.load( f )
 *                 f.close()             # <<<<<<<<<<<<<<
 *                 return
 *             except:
 */
        __Pyx_TraceLine(493,0,__PYX_ERR(0, 493, __pyx_L4_error))
        __pyx_t_8 = __Pyx_PyObject_GetAttrStr(__pyx_v_f, __pyx_n_s_close); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 493, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_8);
        __pyx_t_7 = NULL;
        if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_8))) {
          __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_8);
          if (likely(__pyx_t_7)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_8);
            __Pyx_INCREF(__pyx_t_7);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_8, function);
          }
        }
        __pyx_t_2 = (__pyx_t_7) ? __Pyx_PyObject_CallOneArg(__pyx_t_8, __pyx_t_7) : __Pyx_PyObject_CallNoArg(__pyx_t_8);
        __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
        if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 493, __pyx_L4_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":494
 *                 self.chr_pos_treat_ctrl = cPickle.load( f )
 *                 f.close()
 *                 return             # <<<<<<<<<<<<<<
 *             except:
 *                 temp_fd, temp_filename = mkstemp()
 */
        __Pyx_TraceLine(494,0,__PYX_ERR(0, 494, __pyx_L4_error))
        __Pyx_XDECREF(__pyx_r);
        __pyx_r = Py_None; __Pyx_INCREF(Py_None);
        goto __pyx_L8_try_return;

        /* "MACS2/IO/CallPeakUnit.pyx":490
 *         # values.
 *         if chrom in self.pileup_data_files:
 *             try:             # <<<<<<<<<<<<<<
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )
 *                 self.chr_pos_treat_ctrl = cPickle.load( f )
 */
      }
      __pyx_L4_error:;
      __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":495
 *                 f.close()
 *                 return
 *             except:             # <<<<<<<<<<<<<<
 *                 temp_fd, temp_filename = mkstemp()
 *                 os.close(temp_fd)
 */
      __Pyx_TraceLine(495,0,__PYX_ERR(0, 495, __pyx_L6_except_error))
      /*except:*/ {
        __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__pileup_treat_ctrl_a_chromosome", __pyx_clineno, __pyx_lineno, __pyx_filename);
        if (__Pyx_GetException(&__pyx_t_2, &__pyx_t_8, &__pyx_t_7) < 0) __PYX_ERR(0, 495, __pyx_L6_except_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_GOTREF(__pyx_t_8);
        __Pyx_GOTREF(__pyx_t_7);

        /* "MACS2/IO/CallPeakUnit.pyx":496
 *                 return
 *             except:
 *                 temp_fd, temp_filename = mkstemp()             # <<<<<<<<<<<<<<
 *                 os.close(temp_fd)
 *                 self.pileup_data_files[ chrom ] = temp_filename
 */
        __Pyx_TraceLine(496,0,__PYX_ERR(0, 496, __pyx_L6_except_error))
        __Pyx_GetModuleGlobalName(__pyx_t_10, __pyx_n_s_mkstemp); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 496, __pyx_L6_except_error)
        __Pyx_GOTREF(__pyx_t_10);
        __pyx_t_11 = NULL;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_10))) {
          __pyx_t_11 = PyMethod_GET_SELF(__pyx_t_10);
          if (likely(__pyx_t_11)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_10);
            __Pyx_INCREF(__pyx_t_11);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_10, function);
          }
        }
        __pyx_t_9 = (__pyx_t_11) ? __Pyx_PyObject_CallOneArg(__pyx_t_10, __pyx_t_11) : __Pyx_PyObject_CallNoArg(__pyx_t_10);
        __Pyx_XDECREF(__pyx_t_11); __pyx_t_11 = 0;
        if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 496, __pyx_L6_except_error)
        __Pyx_GOTREF(__pyx_t_9);
        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
        if ((likely(PyTuple_CheckExact(__pyx_t_9))) || (PyList_CheckExact(__pyx_t_9))) {
          PyObject* sequence = __pyx_t_9;
          Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
          if (unlikely(size != 2)) {
            if (size > 2) __Pyx_RaiseTooManyValuesError(2);
            else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
            __PYX_ERR(0, 496, __pyx_L6_except_error)
          }
          #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
          if (likely(PyTuple_CheckExact(sequence))) {
            __pyx_t_10 = PyTuple_GET_ITEM(sequence, 0); 
            __pyx_t_11 = PyTuple_GET_ITEM(sequence, 1); 
          } else {
            __pyx_t_10 = PyList_GET_ITEM(sequence, 0); 
            __pyx_t_11 = PyList_GET_ITEM(sequence, 1); 
          }
          __Pyx_INCREF(__pyx_t_10);
          __Pyx_INCREF(__pyx_t_11);
          #else
          __pyx_t_10 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 496, __pyx_L6_except_error)
          __Pyx_GOTREF(__pyx_t_10);
          __pyx_t_11 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 496, __pyx_L6_except_error)
          __Pyx_GOTREF(__pyx_t_11);
          #endif
          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
        } else {
          Py_ssize_t index = -1;
          __pyx_t_12 = PyObject_GetIter(__pyx_t_9); if (unlikely(!__pyx_t_12)) __PYX_ERR(0, 496, __pyx_L6_except_error)
          __Pyx_GOTREF(__pyx_t_12);
          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
          __pyx_t_13 = Py_TYPE(__pyx_t_12)->tp_iternext;
          index = 0; __pyx_t_10 = __pyx_t_13(__pyx_t_12); if (unlikely(!__pyx_t_10)) goto __pyx_L12_unpacking_failed;
          __Pyx_GOTREF(__pyx_t_10);
          index = 1; __pyx_t_11 = __pyx_t_13(__pyx_t_12); if (unlikely(!__pyx_t_11)) goto __pyx_L12_unpacking_failed;
          __Pyx_GOTREF(__pyx_t_11);
          if (__Pyx_IternextUnpackEndCheck(__pyx_t_13(__pyx_t_12), 2) < 0) __PYX_ERR(0, 496, __pyx_L6_except_error)
          __pyx_t_13 = NULL;
          __Pyx_DECREF(__pyx_t_12); __pyx_t_12 = 0;
          goto __pyx_L13_unpacking_done;
          __pyx_L12_unpacking_failed:;
          __Pyx_DECREF(__pyx_t_12); __pyx_t_12 = 0;
          __pyx_t_13 = NULL;
          if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
          __PYX_ERR(0, 496, __pyx_L6_except_error)
          __pyx_L13_unpacking_done:;
        }
        if (!(likely(PyUnicode_CheckExact(__pyx_t_11))||((__pyx_t_11) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "unicode", Py_TYPE(__pyx_t_11)->tp_name), 0))) __PYX_ERR(0, 496, __pyx_L6_except_error)
        __pyx_v_temp_fd = __pyx_t_10;
        __pyx_t_10 = 0;
        __pyx_v_temp_filename = ((PyObject*)__pyx_t_11);
        __pyx_t_11 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":497
 *             except:
 *                 temp_fd, temp_filename = mkstemp()
 *                 os.close(temp_fd)             # <<<<<<<<<<<<<<
 *                 self.pileup_data_files[ chrom ] = temp_filename
 *         else:
 */
        __Pyx_TraceLine(497,0,__PYX_ERR(0, 497, __pyx_L6_except_error))
        __Pyx_GetModuleGlobalName(__pyx_t_11, __pyx_n_s_os); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 497, __pyx_L6_except_error)
        __Pyx_GOTREF(__pyx_t_11);
        __pyx_t_10 = __Pyx_PyObject_GetAttrStr(__pyx_t_11, __pyx_n_s_close); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 497, __pyx_L6_except_error)
        __Pyx_GOTREF(__pyx_t_10);
        __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
        __pyx_t_11 = NULL;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_10))) {
          __pyx_t_11 = PyMethod_GET_SELF(__pyx_t_10);
          if (likely(__pyx_t_11)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_10);
            __Pyx_INCREF(__pyx_t_11);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_10, function);
          }
        }
        __pyx_t_9 = (__pyx_t_11) ? __Pyx_PyObject_Call2Args(__pyx_t_10, __pyx_t_11, __pyx_v_temp_fd) : __Pyx_PyObject_CallOneArg(__pyx_t_10, __pyx_v_temp_fd);
        __Pyx_XDECREF(__pyx_t_11); __pyx_t_11 = 0;
        if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 497, __pyx_L6_except_error)
        __Pyx_GOTREF(__pyx_t_9);
        __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
        __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":498
 *                 temp_fd, temp_filename = mkstemp()
 *                 os.close(temp_fd)
 *                 self.pileup_data_files[ chrom ] = temp_filename             # <<<<<<<<<<<<<<
 *         else:
 *             temp_fd, temp_filename = mkstemp()
 */
        __Pyx_TraceLine(498,0,__PYX_ERR(0, 498, __pyx_L6_except_error))
        if (unlikely(__pyx_v_self->pileup_data_files == Py_None)) {
          PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
          __PYX_ERR(0, 498, __pyx_L6_except_error)
        }
        if (unlikely(PyDict_SetItem(__pyx_v_self->pileup_data_files, __pyx_v_chrom, __pyx_v_temp_filename) < 0)) __PYX_ERR(0, 498, __pyx_L6_except_error)
        __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
        __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
        goto __pyx_L5_exception_handled;
      }
      __pyx_L6_except_error:;

      /* "MACS2/IO/CallPeakUnit.pyx":490
 *         # values.
 *         if chrom in self.pileup_data_files:
 *             try:             # <<<<<<<<<<<<<<
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )
 *                 self.chr_pos_treat_ctrl = cPickle.load( f )
 */
      __Pyx_XGIVEREF(__pyx_t_4);
      __Pyx_XGIVEREF(__pyx_t_5);
      __Pyx_XGIVEREF(__pyx_t_6);
      __Pyx_ExceptionReset(__pyx_t_4, __pyx_t_5, __pyx_t_6);
      goto __pyx_L1_error;
      __pyx_L8_try_return:;
      __Pyx_XGIVEREF(__pyx_t_4);
      __Pyx_XGIVEREF(__pyx_t_5);
      __Pyx_XGIVEREF(__pyx_t_6);
      __Pyx_ExceptionReset(__pyx_t_4, __pyx_t_5, __pyx_t_6);
      goto __pyx_L0;
      __pyx_L5_exception_handled:;
      __Pyx_XGIVEREF(__pyx_t_4);
      __Pyx_XGIVEREF(__pyx_t_5);
      __Pyx_XGIVEREF(__pyx_t_6);
      __Pyx_ExceptionReset(__pyx_t_4, __pyx_t_5, __pyx_t_6);
    }

    /* "MACS2/IO/CallPeakUnit.pyx":489
 *         # it. Otherwise, load them instead of calculating new pileup
 *         # values.
 *         if chrom in self.pileup_data_files:             # <<<<<<<<<<<<<<
 *             try:
 *                 f = open( self.pileup_data_files[ chrom ],"rb" )
 */
    goto __pyx_L3;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":500
 *                 self.pileup_data_files[ chrom ] = temp_filename
 *         else:
 *             temp_fd, temp_filename = mkstemp()             # <<<<<<<<<<<<<<
 *             os.close(temp_fd)
 *             self.pileup_data_files[ chrom ] = temp_filename.encode()
 */
  __Pyx_TraceLine(500,0,__PYX_ERR(0, 500, __pyx_L1_error))
  /*else*/ {
    __Pyx_GetModuleGlobalName(__pyx_t_8, __pyx_n_s_mkstemp); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 500, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_2 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_8))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_8);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_8);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_8, function);
      }
    }
    __pyx_t_7 = (__pyx_t_2) ? __Pyx_PyObject_CallOneArg(__pyx_t_8, __pyx_t_2) : __Pyx_PyObject_CallNoArg(__pyx_t_8);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 500, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    if ((likely(PyTuple_CheckExact(__pyx_t_7))) || (PyList_CheckExact(__pyx_t_7))) {
      PyObject* sequence = __pyx_t_7;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 2)) {
        if (size > 2) __Pyx_RaiseTooManyValuesError(2);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 500, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      if (likely(PyTuple_CheckExact(sequence))) {
        __pyx_t_8 = PyTuple_GET_ITEM(sequence, 0); 
        __pyx_t_2 = PyTuple_GET_ITEM(sequence, 1); 
      } else {
        __pyx_t_8 = PyList_GET_ITEM(sequence, 0); 
        __pyx_t_2 = PyList_GET_ITEM(sequence, 1); 
      }
      __Pyx_INCREF(__pyx_t_8);
      __Pyx_INCREF(__pyx_t_2);
      #else
      __pyx_t_8 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 500, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __pyx_t_2 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 500, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      #endif
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    } else {
      Py_ssize_t index = -1;
      __pyx_t_9 = PyObject_GetIter(__pyx_t_7); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 500, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_9);
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __pyx_t_13 = Py_TYPE(__pyx_t_9)->tp_iternext;
      index = 0; __pyx_t_8 = __pyx_t_13(__pyx_t_9); if (unlikely(!__pyx_t_8)) goto __pyx_L14_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_8);
      index = 1; __pyx_t_2 = __pyx_t_13(__pyx_t_9); if (unlikely(!__pyx_t_2)) goto __pyx_L14_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_2);
      if (__Pyx_IternextUnpackEndCheck(__pyx_t_13(__pyx_t_9), 2) < 0) __PYX_ERR(0, 500, __pyx_L1_error)
      __pyx_t_13 = NULL;
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      goto __pyx_L15_unpacking_done;
      __pyx_L14_unpacking_failed:;
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __pyx_t_13 = NULL;
      if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
      __PYX_ERR(0, 500, __pyx_L1_error)
      __pyx_L15_unpacking_done:;
    }
    if (!(likely(PyUnicode_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "unicode", Py_TYPE(__pyx_t_2)->tp_name), 0))) __PYX_ERR(0, 500, __pyx_L1_error)
    __pyx_v_temp_fd = __pyx_t_8;
    __pyx_t_8 = 0;
    __pyx_v_temp_filename = ((PyObject*)__pyx_t_2);
    __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":501
 *         else:
 *             temp_fd, temp_filename = mkstemp()
 *             os.close(temp_fd)             # <<<<<<<<<<<<<<
 *             self.pileup_data_files[ chrom ] = temp_filename.encode()
 * 
 */
    __Pyx_TraceLine(501,0,__PYX_ERR(0, 501, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_os); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 501, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_8 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_close); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 501, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_8))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_8);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_8);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_8, function);
      }
    }
    __pyx_t_7 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_8, __pyx_t_2, __pyx_v_temp_fd) : __Pyx_PyObject_CallOneArg(__pyx_t_8, __pyx_v_temp_fd);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 501, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":502
 *             temp_fd, temp_filename = mkstemp()
 *             os.close(temp_fd)
 *             self.pileup_data_files[ chrom ] = temp_filename.encode()             # <<<<<<<<<<<<<<
 * 
 *         # reset or clean existing self.chr_pos_treat_ctrl
 */
    __Pyx_TraceLine(502,0,__PYX_ERR(0, 502, __pyx_L1_error))
    if (unlikely(__pyx_v_temp_filename == Py_None)) {
      PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "encode");
      __PYX_ERR(0, 502, __pyx_L1_error)
    }
    __pyx_t_7 = PyUnicode_AsEncodedString(__pyx_v_temp_filename, NULL, NULL); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 502, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (unlikely(__pyx_v_self->pileup_data_files == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 502, __pyx_L1_error)
    }
    if (unlikely(PyDict_SetItem(__pyx_v_self->pileup_data_files, __pyx_v_chrom, __pyx_t_7) < 0)) __PYX_ERR(0, 502, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  }
  __pyx_L3:;

  /* "MACS2/IO/CallPeakUnit.pyx":505
 * 
 *         # reset or clean existing self.chr_pos_treat_ctrl
 *         if self.chr_pos_treat_ctrl:     # not a beautiful way to clean             # <<<<<<<<<<<<<<
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[0] )
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[1] )
 */
  __Pyx_TraceLine(505,0,__PYX_ERR(0, 505, __pyx_L1_error))
  __pyx_t_3 = (__pyx_v_self->chr_pos_treat_ctrl != Py_None)&&(PyList_GET_SIZE(__pyx_v_self->chr_pos_treat_ctrl) != 0);
  if (__pyx_t_3) {

    /* "MACS2/IO/CallPeakUnit.pyx":506
 *         # reset or clean existing self.chr_pos_treat_ctrl
 *         if self.chr_pos_treat_ctrl:     # not a beautiful way to clean
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[0] )             # <<<<<<<<<<<<<<
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[1] )
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[2] )
 */
    __Pyx_TraceLine(506,0,__PYX_ERR(0, 506, __pyx_L1_error))
    if (unlikely(__pyx_v_self->chr_pos_treat_ctrl == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 506, __pyx_L1_error)
    }
    __pyx_t_7 = __Pyx_GetItemInt_List(__pyx_v_self->chr_pos_treat_ctrl, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 506, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (!(likely(((__pyx_t_7) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_7, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 506, __pyx_L1_error)
    __pyx_f_5MACS2_2IO_12CallPeakUnit_clean_up_ndarray(((PyArrayObject *)__pyx_t_7));
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":507
 *         if self.chr_pos_treat_ctrl:     # not a beautiful way to clean
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[0] )
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[1] )             # <<<<<<<<<<<<<<
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[2] )
 * 
 */
    __Pyx_TraceLine(507,0,__PYX_ERR(0, 507, __pyx_L1_error))
    if (unlikely(__pyx_v_self->chr_pos_treat_ctrl == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 507, __pyx_L1_error)
    }
    __pyx_t_7 = __Pyx_GetItemInt_List(__pyx_v_self->chr_pos_treat_ctrl, 1, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 507, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (!(likely(((__pyx_t_7) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_7, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 507, __pyx_L1_error)
    __pyx_f_5MACS2_2IO_12CallPeakUnit_clean_up_ndarray(((PyArrayObject *)__pyx_t_7));
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":508
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[0] )
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[1] )
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[2] )             # <<<<<<<<<<<<<<
 * 
 *         if self.PE_mode:
 */
    __Pyx_TraceLine(508,0,__PYX_ERR(0, 508, __pyx_L1_error))
    if (unlikely(__pyx_v_self->chr_pos_treat_ctrl == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 508, __pyx_L1_error)
    }
    __pyx_t_7 = __Pyx_GetItemInt_List(__pyx_v_self->chr_pos_treat_ctrl, 2, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 508, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (!(likely(((__pyx_t_7) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_7, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 508, __pyx_L1_error)
    __pyx_f_5MACS2_2IO_12CallPeakUnit_clean_up_ndarray(((PyArrayObject *)__pyx_t_7));
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":505
 * 
 *         # reset or clean existing self.chr_pos_treat_ctrl
 *         if self.chr_pos_treat_ctrl:     # not a beautiful way to clean             # <<<<<<<<<<<<<<
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[0] )
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[1] )
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":510
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[2] )
 * 
 *         if self.PE_mode:             # <<<<<<<<<<<<<<
 *             treat_pv = self.treat.pileup_a_chromosome ( chrom, [self.treat_scaling_factor,], baseline_value = 0.0 )
 *         else:
 */
  __Pyx_TraceLine(510,0,__PYX_ERR(0, 510, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->PE_mode)); if (unlikely(__pyx_t_3 < 0)) __PYX_ERR(0, 510, __pyx_L1_error)
  if (__pyx_t_3) {

    /* "MACS2/IO/CallPeakUnit.pyx":511
 * 
 *         if self.PE_mode:
 *             treat_pv = self.treat.pileup_a_chromosome ( chrom, [self.treat_scaling_factor,], baseline_value = 0.0 )             # <<<<<<<<<<<<<<
 *         else:
 *             treat_pv = self.treat.pileup_a_chromosome( chrom, [self.d,], [self.treat_scaling_factor,], baseline_value = 0.0,
 */
    __Pyx_TraceLine(511,0,__PYX_ERR(0, 511, __pyx_L1_error))
    __pyx_t_7 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_pileup_a_chromosome); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 511, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_8 = PyFloat_FromDouble(__pyx_v_self->treat_scaling_factor); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 511, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_2 = PyList_New(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 511, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_GIVEREF(__pyx_t_8);
    PyList_SET_ITEM(__pyx_t_2, 0, __pyx_t_8);
    __pyx_t_8 = 0;
    __pyx_t_8 = PyTuple_New(2); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 511, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_INCREF(__pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_v_chrom);
    PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_t_2);
    PyTuple_SET_ITEM(__pyx_t_8, 1, __pyx_t_2);
    __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 511, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_baseline_value, __pyx_float_0_0) < 0) __PYX_ERR(0, 511, __pyx_L1_error)
    __pyx_t_9 = __Pyx_PyObject_Call(__pyx_t_7, __pyx_t_8, __pyx_t_2); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 511, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (!(likely(PyList_CheckExact(__pyx_t_9))||((__pyx_t_9) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_9)->tp_name), 0))) __PYX_ERR(0, 511, __pyx_L1_error)
    __pyx_v_treat_pv = ((PyObject*)__pyx_t_9);
    __pyx_t_9 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":510
 *             clean_up_ndarray( self.chr_pos_treat_ctrl[2] )
 * 
 *         if self.PE_mode:             # <<<<<<<<<<<<<<
 *             treat_pv = self.treat.pileup_a_chromosome ( chrom, [self.treat_scaling_factor,], baseline_value = 0.0 )
 *         else:
 */
    goto __pyx_L17;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":513
 *             treat_pv = self.treat.pileup_a_chromosome ( chrom, [self.treat_scaling_factor,], baseline_value = 0.0 )
 *         else:
 *             treat_pv = self.treat.pileup_a_chromosome( chrom, [self.d,], [self.treat_scaling_factor,], baseline_value = 0.0,             # <<<<<<<<<<<<<<
 *                                                        directional = True,
 *                                                        end_shift = self.end_shift )
 */
  __Pyx_TraceLine(513,0,__PYX_ERR(0, 513, __pyx_L1_error))
  /*else*/ {
    __pyx_t_9 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_pileup_a_chromosome); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __pyx_t_2 = __Pyx_PyInt_From_npy_int32(__pyx_v_self->d); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_8 = PyList_New(1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_GIVEREF(__pyx_t_2);
    PyList_SET_ITEM(__pyx_t_8, 0, __pyx_t_2);
    __pyx_t_2 = 0;
    __pyx_t_2 = PyFloat_FromDouble(__pyx_v_self->treat_scaling_factor); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_7 = PyList_New(1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_GIVEREF(__pyx_t_2);
    PyList_SET_ITEM(__pyx_t_7, 0, __pyx_t_2);
    __pyx_t_2 = 0;
    __pyx_t_2 = PyTuple_New(3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_INCREF(__pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_v_chrom);
    PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_t_8);
    PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_t_8);
    __Pyx_GIVEREF(__pyx_t_7);
    PyTuple_SET_ITEM(__pyx_t_2, 2, __pyx_t_7);
    __pyx_t_8 = 0;
    __pyx_t_7 = 0;
    __pyx_t_7 = __Pyx_PyDict_NewPresized(3); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    if (PyDict_SetItem(__pyx_t_7, __pyx_n_s_baseline_value, __pyx_float_0_0) < 0) __PYX_ERR(0, 513, __pyx_L1_error)

    /* "MACS2/IO/CallPeakUnit.pyx":514
 *         else:
 *             treat_pv = self.treat.pileup_a_chromosome( chrom, [self.d,], [self.treat_scaling_factor,], baseline_value = 0.0,
 *                                                        directional = True,             # <<<<<<<<<<<<<<
 *                                                        end_shift = self.end_shift )
 * 
 */
    __Pyx_TraceLine(514,0,__PYX_ERR(0, 514, __pyx_L1_error))
    if (PyDict_SetItem(__pyx_t_7, __pyx_n_s_directional, Py_True) < 0) __PYX_ERR(0, 513, __pyx_L1_error)

    /* "MACS2/IO/CallPeakUnit.pyx":515
 *             treat_pv = self.treat.pileup_a_chromosome( chrom, [self.d,], [self.treat_scaling_factor,], baseline_value = 0.0,
 *                                                        directional = True,
 *                                                        end_shift = self.end_shift )             # <<<<<<<<<<<<<<
 * 
 *         if not self.no_lambda_flag:
 */
    __Pyx_TraceLine(515,0,__PYX_ERR(0, 515, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyInt_From_npy_int32(__pyx_v_self->end_shift); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 515, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_7, __pyx_n_s_end_shift, __pyx_t_8) < 0) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":513
 *             treat_pv = self.treat.pileup_a_chromosome ( chrom, [self.treat_scaling_factor,], baseline_value = 0.0 )
 *         else:
 *             treat_pv = self.treat.pileup_a_chromosome( chrom, [self.d,], [self.treat_scaling_factor,], baseline_value = 0.0,             # <<<<<<<<<<<<<<
 *                                                        directional = True,
 *                                                        end_shift = self.end_shift )
 */
    __Pyx_TraceLine(513,0,__PYX_ERR(0, 513, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyObject_Call(__pyx_t_9, __pyx_t_2, __pyx_t_7); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 513, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    if (!(likely(PyList_CheckExact(__pyx_t_8))||((__pyx_t_8) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_8)->tp_name), 0))) __PYX_ERR(0, 513, __pyx_L1_error)
    __pyx_v_treat_pv = ((PyObject*)__pyx_t_8);
    __pyx_t_8 = 0;
  }
  __pyx_L17:;

  /* "MACS2/IO/CallPeakUnit.pyx":517
 *                                                        end_shift = self.end_shift )
 * 
 *         if not self.no_lambda_flag:             # <<<<<<<<<<<<<<
 *             if self.PE_mode:
 *                 # note, we pileup up PE control as SE control because
 */
  __Pyx_TraceLine(517,0,__PYX_ERR(0, 517, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->no_lambda_flag)); if (unlikely(__pyx_t_3 < 0)) __PYX_ERR(0, 517, __pyx_L1_error)
  __pyx_t_1 = ((!__pyx_t_3) != 0);
  if (__pyx_t_1) {

    /* "MACS2/IO/CallPeakUnit.pyx":518
 * 
 *         if not self.no_lambda_flag:
 *             if self.PE_mode:             # <<<<<<<<<<<<<<
 *                 # note, we pileup up PE control as SE control because
 *                 # we assume the bias only can be captured at the
 */
    __Pyx_TraceLine(518,0,__PYX_ERR(0, 518, __pyx_L1_error))
    __pyx_t_1 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->PE_mode)); if (unlikely(__pyx_t_1 < 0)) __PYX_ERR(0, 518, __pyx_L1_error)
    if (__pyx_t_1) {

      /* "MACS2/IO/CallPeakUnit.pyx":522
 *                 # we assume the bias only can be captured at the
 *                 # surrounding regions of cutting sites from control experiments.
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome_c( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s, baseline_value = self.lambda_bg )             # <<<<<<<<<<<<<<
 *             else:
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s,
 */
      __Pyx_TraceLine(522,0,__PYX_ERR(0, 522, __pyx_L1_error))
      __pyx_t_8 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->ctrl, __pyx_n_s_pileup_a_chromosome_c); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 522, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __pyx_t_7 = PyTuple_New(3); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 522, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_7);
      __Pyx_INCREF(__pyx_v_chrom);
      __Pyx_GIVEREF(__pyx_v_chrom);
      PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_v_chrom);
      __Pyx_INCREF(__pyx_v_self->ctrl_d_s);
      __Pyx_GIVEREF(__pyx_v_self->ctrl_d_s);
      PyTuple_SET_ITEM(__pyx_t_7, 1, __pyx_v_self->ctrl_d_s);
      __Pyx_INCREF(__pyx_v_self->ctrl_scaling_factor_s);
      __Pyx_GIVEREF(__pyx_v_self->ctrl_scaling_factor_s);
      PyTuple_SET_ITEM(__pyx_t_7, 2, __pyx_v_self->ctrl_scaling_factor_s);
      __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 522, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_9 = PyFloat_FromDouble(__pyx_v_self->lambda_bg); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 522, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_9);
      if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_baseline_value, __pyx_t_9) < 0) __PYX_ERR(0, 522, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __pyx_t_9 = __Pyx_PyObject_Call(__pyx_t_8, __pyx_t_7, __pyx_t_2); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 522, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_9);
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (!(likely(PyList_CheckExact(__pyx_t_9))||((__pyx_t_9) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_9)->tp_name), 0))) __PYX_ERR(0, 522, __pyx_L1_error)
      __pyx_v_ctrl_pv = ((PyObject*)__pyx_t_9);
      __pyx_t_9 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":518
 * 
 *         if not self.no_lambda_flag:
 *             if self.PE_mode:             # <<<<<<<<<<<<<<
 *                 # note, we pileup up PE control as SE control because
 *                 # we assume the bias only can be captured at the
 */
      goto __pyx_L19;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":524
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome_c( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s, baseline_value = self.lambda_bg )
 *             else:
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s,             # <<<<<<<<<<<<<<
 *                                                          baseline_value = self.lambda_bg,
 *                                                          directional = False )
 */
    __Pyx_TraceLine(524,0,__PYX_ERR(0, 524, __pyx_L1_error))
    /*else*/ {
      __pyx_t_9 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->ctrl, __pyx_n_s_pileup_a_chromosome); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 524, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_9);
      __pyx_t_2 = PyTuple_New(3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 524, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_INCREF(__pyx_v_chrom);
      __Pyx_GIVEREF(__pyx_v_chrom);
      PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_v_chrom);
      __Pyx_INCREF(__pyx_v_self->ctrl_d_s);
      __Pyx_GIVEREF(__pyx_v_self->ctrl_d_s);
      PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_v_self->ctrl_d_s);
      __Pyx_INCREF(__pyx_v_self->ctrl_scaling_factor_s);
      __Pyx_GIVEREF(__pyx_v_self->ctrl_scaling_factor_s);
      PyTuple_SET_ITEM(__pyx_t_2, 2, __pyx_v_self->ctrl_scaling_factor_s);

      /* "MACS2/IO/CallPeakUnit.pyx":525
 *             else:
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s,
 *                                                          baseline_value = self.lambda_bg,             # <<<<<<<<<<<<<<
 *                                                          directional = False )
 *         else:
 */
      __Pyx_TraceLine(525,0,__PYX_ERR(0, 525, __pyx_L1_error))
      __pyx_t_7 = __Pyx_PyDict_NewPresized(2); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 525, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_7);
      __pyx_t_8 = PyFloat_FromDouble(__pyx_v_self->lambda_bg); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 525, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      if (PyDict_SetItem(__pyx_t_7, __pyx_n_s_baseline_value, __pyx_t_8) < 0) __PYX_ERR(0, 525, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":526
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s,
 *                                                          baseline_value = self.lambda_bg,
 *                                                          directional = False )             # <<<<<<<<<<<<<<
 *         else:
 *             ctrl_pv = [treat_pv[0][-1:], np.array([self.lambda_bg,], dtype="float32")] # set a global lambda
 */
      __Pyx_TraceLine(526,0,__PYX_ERR(0, 526, __pyx_L1_error))
      if (PyDict_SetItem(__pyx_t_7, __pyx_n_s_directional, Py_False) < 0) __PYX_ERR(0, 525, __pyx_L1_error)

      /* "MACS2/IO/CallPeakUnit.pyx":524
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome_c( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s, baseline_value = self.lambda_bg )
 *             else:
 *                 ctrl_pv = self.ctrl.pileup_a_chromosome( chrom, self.ctrl_d_s, self.ctrl_scaling_factor_s,             # <<<<<<<<<<<<<<
 *                                                          baseline_value = self.lambda_bg,
 *                                                          directional = False )
 */
      __Pyx_TraceLine(524,0,__PYX_ERR(0, 524, __pyx_L1_error))
      __pyx_t_8 = __Pyx_PyObject_Call(__pyx_t_9, __pyx_t_2, __pyx_t_7); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 524, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      if (!(likely(PyList_CheckExact(__pyx_t_8))||((__pyx_t_8) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_8)->tp_name), 0))) __PYX_ERR(0, 524, __pyx_L1_error)
      __pyx_v_ctrl_pv = ((PyObject*)__pyx_t_8);
      __pyx_t_8 = 0;
    }
    __pyx_L19:;

    /* "MACS2/IO/CallPeakUnit.pyx":517
 *                                                        end_shift = self.end_shift )
 * 
 *         if not self.no_lambda_flag:             # <<<<<<<<<<<<<<
 *             if self.PE_mode:
 *                 # note, we pileup up PE control as SE control because
 */
    goto __pyx_L18;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":528
 *                                                          directional = False )
 *         else:
 *             ctrl_pv = [treat_pv[0][-1:], np.array([self.lambda_bg,], dtype="float32")] # set a global lambda             # <<<<<<<<<<<<<<
 * 
 *         self.chr_pos_treat_ctrl = self.__chrom_pair_treat_ctrl( treat_pv, ctrl_pv)
 */
  __Pyx_TraceLine(528,0,__PYX_ERR(0, 528, __pyx_L1_error))
  /*else*/ {
    if (unlikely(__pyx_v_treat_pv == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 528, __pyx_L1_error)
    }
    __pyx_t_8 = __Pyx_GetItemInt_List(__pyx_v_treat_pv, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_7 = __Pyx_PyObject_GetSlice(__pyx_t_8, -1L, 0, NULL, NULL, &__pyx_slice__7, 1, 0, 1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_GetModuleGlobalName(__pyx_t_8, __pyx_n_s_np); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_8, __pyx_n_s_array); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_8 = PyFloat_FromDouble(__pyx_v_self->lambda_bg); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_9 = PyList_New(1); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_GIVEREF(__pyx_t_8);
    PyList_SET_ITEM(__pyx_t_9, 0, __pyx_t_8);
    __pyx_t_8 = 0;
    __pyx_t_8 = PyTuple_New(1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_GIVEREF(__pyx_t_9);
    PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_t_9);
    __pyx_t_9 = 0;
    __pyx_t_9 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 528, __pyx_L1_error)
    __pyx_t_10 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_8, __pyx_t_9); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __pyx_t_9 = PyList_New(2); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 528, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_GIVEREF(__pyx_t_7);
    PyList_SET_ITEM(__pyx_t_9, 0, __pyx_t_7);
    __Pyx_GIVEREF(__pyx_t_10);
    PyList_SET_ITEM(__pyx_t_9, 1, __pyx_t_10);
    __pyx_t_7 = 0;
    __pyx_t_10 = 0;
    __pyx_v_ctrl_pv = ((PyObject*)__pyx_t_9);
    __pyx_t_9 = 0;
  }
  __pyx_L18:;

  /* "MACS2/IO/CallPeakUnit.pyx":530
 *             ctrl_pv = [treat_pv[0][-1:], np.array([self.lambda_bg,], dtype="float32")] # set a global lambda
 * 
 *         self.chr_pos_treat_ctrl = self.__chrom_pair_treat_ctrl( treat_pv, ctrl_pv)             # <<<<<<<<<<<<<<
 * 
 *         # clean treat_pv and ctrl_pv
 */
  __Pyx_TraceLine(530,0,__PYX_ERR(0, 530, __pyx_L1_error))
  __pyx_t_9 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___chrom_pair_treat_ctrl(__pyx_v_self, __pyx_v_treat_pv, __pyx_v_ctrl_pv); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 530, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_9);
  __Pyx_GIVEREF(__pyx_t_9);
  __Pyx_GOTREF(__pyx_v_self->chr_pos_treat_ctrl);
  __Pyx_DECREF(__pyx_v_self->chr_pos_treat_ctrl);
  __pyx_v_self->chr_pos_treat_ctrl = ((PyObject*)__pyx_t_9);
  __pyx_t_9 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":533
 * 
 *         # clean treat_pv and ctrl_pv
 *         treat_pv = []             # <<<<<<<<<<<<<<
 *         ctrl_pv  = []
 * 
 */
  __Pyx_TraceLine(533,0,__PYX_ERR(0, 533, __pyx_L1_error))
  __pyx_t_9 = PyList_New(0); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 533, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_9);
  __Pyx_DECREF_SET(__pyx_v_treat_pv, ((PyObject*)__pyx_t_9));
  __pyx_t_9 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":534
 *         # clean treat_pv and ctrl_pv
 *         treat_pv = []
 *         ctrl_pv  = []             # <<<<<<<<<<<<<<
 * 
 *         # save data to temporary file
 */
  __Pyx_TraceLine(534,0,__PYX_ERR(0, 534, __pyx_L1_error))
  __pyx_t_9 = PyList_New(0); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 534, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_9);
  __Pyx_DECREF_SET(__pyx_v_ctrl_pv, ((PyObject*)__pyx_t_9));
  __pyx_t_9 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":537
 * 
 *         # save data to temporary file
 *         try:             # <<<<<<<<<<<<<<
 *             f = open(self.pileup_data_files[ chrom ],"wb")
 *             cPickle.dump( self.chr_pos_treat_ctrl, f , protocol=2 )
 */
  __Pyx_TraceLine(537,0,__PYX_ERR(0, 537, __pyx_L1_error))
  {
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ExceptionSave(&__pyx_t_6, &__pyx_t_5, &__pyx_t_4);
    __Pyx_XGOTREF(__pyx_t_6);
    __Pyx_XGOTREF(__pyx_t_5);
    __Pyx_XGOTREF(__pyx_t_4);
    /*try:*/ {

      /* "MACS2/IO/CallPeakUnit.pyx":538
 *         # save data to temporary file
 *         try:
 *             f = open(self.pileup_data_files[ chrom ],"wb")             # <<<<<<<<<<<<<<
 *             cPickle.dump( self.chr_pos_treat_ctrl, f , protocol=2 )
 *             f.close()
 */
      __Pyx_TraceLine(538,0,__PYX_ERR(0, 538, __pyx_L20_error))
      if (unlikely(__pyx_v_self->pileup_data_files == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 538, __pyx_L20_error)
      }
      __pyx_t_9 = __Pyx_PyDict_GetItem(__pyx_v_self->pileup_data_files, __pyx_v_chrom); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 538, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_9);
      __pyx_t_10 = PyTuple_New(2); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 538, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_10);
      __Pyx_GIVEREF(__pyx_t_9);
      PyTuple_SET_ITEM(__pyx_t_10, 0, __pyx_t_9);
      __Pyx_INCREF(__pyx_n_u_wb);
      __Pyx_GIVEREF(__pyx_n_u_wb);
      PyTuple_SET_ITEM(__pyx_t_10, 1, __pyx_n_u_wb);
      __pyx_t_9 = 0;
      __pyx_t_9 = __Pyx_PyObject_Call(__pyx_builtin_open, __pyx_t_10, NULL); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 538, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_9);
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __Pyx_XDECREF_SET(__pyx_v_f, __pyx_t_9);
      __pyx_t_9 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":539
 *         try:
 *             f = open(self.pileup_data_files[ chrom ],"wb")
 *             cPickle.dump( self.chr_pos_treat_ctrl, f , protocol=2 )             # <<<<<<<<<<<<<<
 *             f.close()
 *         except:
 */
      __Pyx_TraceLine(539,0,__PYX_ERR(0, 539, __pyx_L20_error))
      __Pyx_GetModuleGlobalName(__pyx_t_9, __pyx_n_s_cPickle); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 539, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_9);
      __pyx_t_10 = __Pyx_PyObject_GetAttrStr(__pyx_t_9, __pyx_n_s_dump); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 539, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_10);
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __pyx_t_9 = PyTuple_New(2); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 539, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_9);
      __Pyx_INCREF(__pyx_v_self->chr_pos_treat_ctrl);
      __Pyx_GIVEREF(__pyx_v_self->chr_pos_treat_ctrl);
      PyTuple_SET_ITEM(__pyx_t_9, 0, __pyx_v_self->chr_pos_treat_ctrl);
      __Pyx_INCREF(__pyx_v_f);
      __Pyx_GIVEREF(__pyx_v_f);
      PyTuple_SET_ITEM(__pyx_t_9, 1, __pyx_v_f);
      __pyx_t_7 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 539, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_7);
      if (PyDict_SetItem(__pyx_t_7, __pyx_n_s_protocol, __pyx_int_2) < 0) __PYX_ERR(0, 539, __pyx_L20_error)
      __pyx_t_8 = __Pyx_PyObject_Call(__pyx_t_10, __pyx_t_9, __pyx_t_7); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 539, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":540
 *             f = open(self.pileup_data_files[ chrom ],"wb")
 *             cPickle.dump( self.chr_pos_treat_ctrl, f , protocol=2 )
 *             f.close()             # <<<<<<<<<<<<<<
 *         except:
 *             # fail to write then remove the key in pileup_data_files
 */
      __Pyx_TraceLine(540,0,__PYX_ERR(0, 540, __pyx_L20_error))
      __pyx_t_7 = __Pyx_PyObject_GetAttrStr(__pyx_v_f, __pyx_n_s_close); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 540, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_7);
      __pyx_t_9 = NULL;
      if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_7))) {
        __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_7);
        if (likely(__pyx_t_9)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_7);
          __Pyx_INCREF(__pyx_t_9);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_7, function);
        }
      }
      __pyx_t_8 = (__pyx_t_9) ? __Pyx_PyObject_CallOneArg(__pyx_t_7, __pyx_t_9) : __Pyx_PyObject_CallNoArg(__pyx_t_7);
      __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
      if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 540, __pyx_L20_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":537
 * 
 *         # save data to temporary file
 *         try:             # <<<<<<<<<<<<<<
 *             f = open(self.pileup_data_files[ chrom ],"wb")
 *             cPickle.dump( self.chr_pos_treat_ctrl, f , protocol=2 )
 */
    }
    __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
    goto __pyx_L25_try_end;
    __pyx_L20_error:;
    __Pyx_XDECREF(__pyx_t_10); __pyx_t_10 = 0;
    __Pyx_XDECREF(__pyx_t_11); __pyx_t_11 = 0;
    __Pyx_XDECREF(__pyx_t_12); __pyx_t_12 = 0;
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":541
 *             cPickle.dump( self.chr_pos_treat_ctrl, f , protocol=2 )
 *             f.close()
 *         except:             # <<<<<<<<<<<<<<
 *             # fail to write then remove the key in pileup_data_files
 *             self.pileup_data_files.pop(chrom)
 */
    __Pyx_TraceLine(541,0,__PYX_ERR(0, 541, __pyx_L22_except_error))
    /*except:*/ {
      __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__pileup_treat_ctrl_a_chromosome", __pyx_clineno, __pyx_lineno, __pyx_filename);
      if (__Pyx_GetException(&__pyx_t_8, &__pyx_t_7, &__pyx_t_9) < 0) __PYX_ERR(0, 541, __pyx_L22_except_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_GOTREF(__pyx_t_7);
      __Pyx_GOTREF(__pyx_t_9);

      /* "MACS2/IO/CallPeakUnit.pyx":543
 *         except:
 *             # fail to write then remove the key in pileup_data_files
 *             self.pileup_data_files.pop(chrom)             # <<<<<<<<<<<<<<
 *         return
 * 
 */
      __Pyx_TraceLine(543,0,__PYX_ERR(0, 543, __pyx_L22_except_error))
      if (unlikely(__pyx_v_self->pileup_data_files == Py_None)) {
        PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "pop");
        __PYX_ERR(0, 543, __pyx_L22_except_error)
      }
      __pyx_t_10 = __Pyx_PyDict_Pop(__pyx_v_self->pileup_data_files, __pyx_v_chrom, ((PyObject *)NULL)); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 543, __pyx_L22_except_error)
      __Pyx_GOTREF(__pyx_t_10);
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
      goto __pyx_L21_exception_handled;
    }
    __pyx_L22_except_error:;

    /* "MACS2/IO/CallPeakUnit.pyx":537
 * 
 *         # save data to temporary file
 *         try:             # <<<<<<<<<<<<<<
 *             f = open(self.pileup_data_files[ chrom ],"wb")
 *             cPickle.dump( self.chr_pos_treat_ctrl, f , protocol=2 )
 */
    __Pyx_XGIVEREF(__pyx_t_6);
    __Pyx_XGIVEREF(__pyx_t_5);
    __Pyx_XGIVEREF(__pyx_t_4);
    __Pyx_ExceptionReset(__pyx_t_6, __pyx_t_5, __pyx_t_4);
    goto __pyx_L1_error;
    __pyx_L21_exception_handled:;
    __Pyx_XGIVEREF(__pyx_t_6);
    __Pyx_XGIVEREF(__pyx_t_5);
    __Pyx_XGIVEREF(__pyx_t_4);
    __Pyx_ExceptionReset(__pyx_t_6, __pyx_t_5, __pyx_t_4);
    __pyx_L25_try_end:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":544
 *             # fail to write then remove the key in pileup_data_files
 *             self.pileup_data_files.pop(chrom)
 *         return             # <<<<<<<<<<<<<<
 * 
 *     cdef list __chrom_pair_treat_ctrl ( self, treat_pv, ctrl_pv ):
 */
  __Pyx_TraceLine(544,0,__PYX_ERR(0, 544, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_r = Py_None; __Pyx_INCREF(Py_None);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":471
 *         self.trackline = True
 * 
 *     cdef __pileup_treat_ctrl_a_chromosome ( self, bytes chrom ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.chr_pos_treat_ctrl will
 *         be reset and assigned to the pileup values of the given
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_XDECREF(__pyx_t_9);
  __Pyx_XDECREF(__pyx_t_10);
  __Pyx_XDECREF(__pyx_t_11);
  __Pyx_XDECREF(__pyx_t_12);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__pileup_treat_ctrl_a_chromosome", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_treat_pv);
  __Pyx_XDECREF(__pyx_v_ctrl_pv);
  __Pyx_XDECREF(__pyx_v_f);
  __Pyx_XDECREF(__pyx_v_temp_filename);
  __Pyx_XDECREF(__pyx_v_temp_fd);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":546
 *         return
 * 
 *     cdef list __chrom_pair_treat_ctrl ( self, treat_pv, ctrl_pv ):             # <<<<<<<<<<<<<<
 *         """*private* Pair treat and ctrl pileup for each region.
 * 
 */

static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_pair_treat_ctrl(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_treat_pv, PyObject *__pyx_v_ctrl_pv) {
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_pre_p;
  __pyx_t_5numpy_int64_t __pyx_v_index_ret;
  __pyx_t_5numpy_int64_t __pyx_v_it;
  __pyx_t_5numpy_int64_t __pyx_v_ic;
  __pyx_t_5numpy_int64_t __pyx_v_lt;
  __pyx_t_5numpy_int64_t __pyx_v_lc;
  PyArrayObject *__pyx_v_t_p = 0;
  PyArrayObject *__pyx_v_c_p = 0;
  PyArrayObject *__pyx_v_ret_p = 0;
  PyArrayObject *__pyx_v_t_v = 0;
  PyArrayObject *__pyx_v_c_v = 0;
  PyArrayObject *__pyx_v_ret_t = 0;
  PyArrayObject *__pyx_v_ret_c = 0;
  __pyx_t_5numpy_int32_t *__pyx_v_t_p_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_c_p_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_ret_p_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_t_v_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_c_v_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_ret_t_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_ret_c_ptr;
  __pyx_t_5numpy_int64_t __pyx_v_chrom_max_len;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_c_p;
  __Pyx_Buffer __pyx_pybuffer_c_p;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_c_v;
  __Pyx_Buffer __pyx_pybuffer_c_v;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_ret_c;
  __Pyx_Buffer __pyx_pybuffer_ret_c;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_ret_p;
  __Pyx_Buffer __pyx_pybuffer_ret_p;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_ret_t;
  __Pyx_Buffer __pyx_pybuffer_ret_t;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_t_p;
  __Pyx_Buffer __pyx_pybuffer_t_p;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_t_v;
  __Pyx_Buffer __pyx_pybuffer_t_v;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *(*__pyx_t_4)(PyObject *);
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  PyArrayObject *__pyx_t_10 = NULL;
  PyObject *__pyx_t_11 = NULL;
  int __pyx_t_12;
  int __pyx_t_13;
  __Pyx_RefNannySetupContext("__chrom_pair_treat_ctrl", 0);
  __Pyx_TraceCall("__chrom_pair_treat_ctrl", __pyx_f[0], 546, 0, __PYX_ERR(0, 546, __pyx_L1_error));
  __pyx_pybuffer_t_p.pybuffer.buf = NULL;
  __pyx_pybuffer_t_p.refcount = 0;
  __pyx_pybuffernd_t_p.data = NULL;
  __pyx_pybuffernd_t_p.rcbuffer = &__pyx_pybuffer_t_p;
  __pyx_pybuffer_c_p.pybuffer.buf = NULL;
  __pyx_pybuffer_c_p.refcount = 0;
  __pyx_pybuffernd_c_p.data = NULL;
  __pyx_pybuffernd_c_p.rcbuffer = &__pyx_pybuffer_c_p;
  __pyx_pybuffer_ret_p.pybuffer.buf = NULL;
  __pyx_pybuffer_ret_p.refcount = 0;
  __pyx_pybuffernd_ret_p.data = NULL;
  __pyx_pybuffernd_ret_p.rcbuffer = &__pyx_pybuffer_ret_p;
  __pyx_pybuffer_t_v.pybuffer.buf = NULL;
  __pyx_pybuffer_t_v.refcount = 0;
  __pyx_pybuffernd_t_v.data = NULL;
  __pyx_pybuffernd_t_v.rcbuffer = &__pyx_pybuffer_t_v;
  __pyx_pybuffer_c_v.pybuffer.buf = NULL;
  __pyx_pybuffer_c_v.refcount = 0;
  __pyx_pybuffernd_c_v.data = NULL;
  __pyx_pybuffernd_c_v.rcbuffer = &__pyx_pybuffer_c_v;
  __pyx_pybuffer_ret_t.pybuffer.buf = NULL;
  __pyx_pybuffer_ret_t.refcount = 0;
  __pyx_pybuffernd_ret_t.data = NULL;
  __pyx_pybuffernd_ret_t.rcbuffer = &__pyx_pybuffer_ret_t;
  __pyx_pybuffer_ret_c.pybuffer.buf = NULL;
  __pyx_pybuffer_ret_c.refcount = 0;
  __pyx_pybuffernd_ret_c.data = NULL;
  __pyx_pybuffernd_ret_c.rcbuffer = &__pyx_pybuffer_ret_c;

  /* "MACS2/IO/CallPeakUnit.pyx":568
 *             float32_t * ret_c_ptr
 * 
 *         [ t_p, t_v ] = treat_pv             # <<<<<<<<<<<<<<
 *         [ c_p, c_v ] = ctrl_pv
 * 
 */
  __Pyx_TraceLine(568,0,__PYX_ERR(0, 568, __pyx_L1_error))
  if ((likely(PyTuple_CheckExact(__pyx_v_treat_pv))) || (PyList_CheckExact(__pyx_v_treat_pv))) {
    PyObject* sequence = __pyx_v_treat_pv;
    Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
    if (unlikely(size != 2)) {
      if (size > 2) __Pyx_RaiseTooManyValuesError(2);
      else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
      __PYX_ERR(0, 568, __pyx_L1_error)
    }
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    if (likely(PyTuple_CheckExact(sequence))) {
      __pyx_t_1 = PyTuple_GET_ITEM(sequence, 0); 
      __pyx_t_2 = PyTuple_GET_ITEM(sequence, 1); 
    } else {
      __pyx_t_1 = PyList_GET_ITEM(sequence, 0); 
      __pyx_t_2 = PyList_GET_ITEM(sequence, 1); 
    }
    __Pyx_INCREF(__pyx_t_1);
    __Pyx_INCREF(__pyx_t_2);
    #else
    __pyx_t_1 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 568, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_2 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 568, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    #endif
  } else {
    Py_ssize_t index = -1;
    __pyx_t_3 = PyObject_GetIter(__pyx_v_treat_pv); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 568, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_4 = Py_TYPE(__pyx_t_3)->tp_iternext;
    index = 0; __pyx_t_1 = __pyx_t_4(__pyx_t_3); if (unlikely(!__pyx_t_1)) goto __pyx_L3_unpacking_failed;
    __Pyx_GOTREF(__pyx_t_1);
    index = 1; __pyx_t_2 = __pyx_t_4(__pyx_t_3); if (unlikely(!__pyx_t_2)) goto __pyx_L3_unpacking_failed;
    __Pyx_GOTREF(__pyx_t_2);
    if (__Pyx_IternextUnpackEndCheck(__pyx_t_4(__pyx_t_3), 2) < 0) __PYX_ERR(0, 568, __pyx_L1_error)
    __pyx_t_4 = NULL;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    goto __pyx_L4_unpacking_done;
    __pyx_L3_unpacking_failed:;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_4 = NULL;
    if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
    __PYX_ERR(0, 568, __pyx_L1_error)
    __pyx_L4_unpacking_done:;
  }
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 568, __pyx_L1_error)
  if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 568, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_1);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_t_p.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_t_p.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_t_p.rcbuffer->pybuffer, (PyObject*)__pyx_v_t_p, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_t_p.diminfo[0].strides = __pyx_pybuffernd_t_p.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_t_p.diminfo[0].shape = __pyx_pybuffernd_t_p.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 568, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_t_p = ((PyArrayObject *)__pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_10 = ((PyArrayObject *)__pyx_t_2);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_t_v.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_t_v.rcbuffer->pybuffer, (PyObject*)__pyx_t_10, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_8, &__pyx_t_7);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_t_v.rcbuffer->pybuffer, (PyObject*)__pyx_v_t_v, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_7);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_8, __pyx_t_7);
      }
      __pyx_t_9 = __pyx_t_8 = __pyx_t_7 = 0;
    }
    __pyx_pybuffernd_t_v.diminfo[0].strides = __pyx_pybuffernd_t_v.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_t_v.diminfo[0].shape = __pyx_pybuffernd_t_v.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 568, __pyx_L1_error)
  }
  __pyx_t_10 = 0;
  __pyx_v_t_v = ((PyArrayObject *)__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":569
 * 
 *         [ t_p, t_v ] = treat_pv
 *         [ c_p, c_v ] = ctrl_pv             # <<<<<<<<<<<<<<
 * 
 *         lt = t_p.shape[0]
 */
  __Pyx_TraceLine(569,0,__PYX_ERR(0, 569, __pyx_L1_error))
  if ((likely(PyTuple_CheckExact(__pyx_v_ctrl_pv))) || (PyList_CheckExact(__pyx_v_ctrl_pv))) {
    PyObject* sequence = __pyx_v_ctrl_pv;
    Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
    if (unlikely(size != 2)) {
      if (size > 2) __Pyx_RaiseTooManyValuesError(2);
      else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
      __PYX_ERR(0, 569, __pyx_L1_error)
    }
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    if (likely(PyTuple_CheckExact(sequence))) {
      __pyx_t_2 = PyTuple_GET_ITEM(sequence, 0); 
      __pyx_t_1 = PyTuple_GET_ITEM(sequence, 1); 
    } else {
      __pyx_t_2 = PyList_GET_ITEM(sequence, 0); 
      __pyx_t_1 = PyList_GET_ITEM(sequence, 1); 
    }
    __Pyx_INCREF(__pyx_t_2);
    __Pyx_INCREF(__pyx_t_1);
    #else
    __pyx_t_2 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 569, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_1 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 569, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    #endif
  } else {
    Py_ssize_t index = -1;
    __pyx_t_3 = PyObject_GetIter(__pyx_v_ctrl_pv); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 569, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_4 = Py_TYPE(__pyx_t_3)->tp_iternext;
    index = 0; __pyx_t_2 = __pyx_t_4(__pyx_t_3); if (unlikely(!__pyx_t_2)) goto __pyx_L5_unpacking_failed;
    __Pyx_GOTREF(__pyx_t_2);
    index = 1; __pyx_t_1 = __pyx_t_4(__pyx_t_3); if (unlikely(!__pyx_t_1)) goto __pyx_L5_unpacking_failed;
    __Pyx_GOTREF(__pyx_t_1);
    if (__Pyx_IternextUnpackEndCheck(__pyx_t_4(__pyx_t_3), 2) < 0) __PYX_ERR(0, 569, __pyx_L1_error)
    __pyx_t_4 = NULL;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    goto __pyx_L6_unpacking_done;
    __pyx_L5_unpacking_failed:;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_4 = NULL;
    if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
    __PYX_ERR(0, 569, __pyx_L1_error)
    __pyx_L6_unpacking_done:;
  }
  if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 569, __pyx_L1_error)
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 569, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_2);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_c_p.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_c_p.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_c_p.rcbuffer->pybuffer, (PyObject*)__pyx_v_c_p, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_c_p.diminfo[0].strides = __pyx_pybuffernd_c_p.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_c_p.diminfo[0].shape = __pyx_pybuffernd_c_p.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 569, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_c_p = ((PyArrayObject *)__pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_10 = ((PyArrayObject *)__pyx_t_1);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_c_v.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_c_v.rcbuffer->pybuffer, (PyObject*)__pyx_t_10, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_8, &__pyx_t_7);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_c_v.rcbuffer->pybuffer, (PyObject*)__pyx_v_c_v, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_7);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_8, __pyx_t_7);
      }
      __pyx_t_9 = __pyx_t_8 = __pyx_t_7 = 0;
    }
    __pyx_pybuffernd_c_v.diminfo[0].strides = __pyx_pybuffernd_c_v.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_c_v.diminfo[0].shape = __pyx_pybuffernd_c_v.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 569, __pyx_L1_error)
  }
  __pyx_t_10 = 0;
  __pyx_v_c_v = ((PyArrayObject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":571
 *         [ c_p, c_v ] = ctrl_pv
 * 
 *         lt = t_p.shape[0]             # <<<<<<<<<<<<<<
 *         lc = c_p.shape[0]
 * 
 */
  __Pyx_TraceLine(571,0,__PYX_ERR(0, 571, __pyx_L1_error))
  __pyx_v_lt = (__pyx_v_t_p->dimensions[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":572
 * 
 *         lt = t_p.shape[0]
 *         lc = c_p.shape[0]             # <<<<<<<<<<<<<<
 * 
 *         chrom_max_len = lt + lc
 */
  __Pyx_TraceLine(572,0,__PYX_ERR(0, 572, __pyx_L1_error))
  __pyx_v_lc = (__pyx_v_c_p->dimensions[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":574
 *         lc = c_p.shape[0]
 * 
 *         chrom_max_len = lt + lc             # <<<<<<<<<<<<<<
 * 
 *         ret_p = np.zeros( chrom_max_len, dtype="int32" ) # position
 */
  __Pyx_TraceLine(574,0,__PYX_ERR(0, 574, __pyx_L1_error))
  __pyx_v_chrom_max_len = (__pyx_v_lt + __pyx_v_lc);

  /* "MACS2/IO/CallPeakUnit.pyx":576
 *         chrom_max_len = lt + lc
 * 
 *         ret_p = np.zeros( chrom_max_len, dtype="int32" ) # position             # <<<<<<<<<<<<<<
 *         ret_t = np.zeros( chrom_max_len, dtype="float32" ) # value from treatment
 *         ret_c = np.zeros( chrom_max_len, dtype="float32" ) # value from control
 */
  __Pyx_TraceLine(576,0,__PYX_ERR(0, 576, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 576, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 576, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_npy_int64(__pyx_v_chrom_max_len); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 576, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 576, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 576, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_int32) < 0) __PYX_ERR(0, 576, __pyx_L1_error)
  __pyx_t_11 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 576, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_11) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_11, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 576, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_11);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_p.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ret_p.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ret_p.rcbuffer->pybuffer, (PyObject*)__pyx_v_ret_p, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_ret_p.diminfo[0].strides = __pyx_pybuffernd_ret_p.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_ret_p.diminfo[0].shape = __pyx_pybuffernd_ret_p.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 576, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_ret_p = ((PyArrayObject *)__pyx_t_11);
  __pyx_t_11 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":577
 * 
 *         ret_p = np.zeros( chrom_max_len, dtype="int32" ) # position
 *         ret_t = np.zeros( chrom_max_len, dtype="float32" ) # value from treatment             # <<<<<<<<<<<<<<
 *         ret_c = np.zeros( chrom_max_len, dtype="float32" ) # value from control
 * 
 */
  __Pyx_TraceLine(577,0,__PYX_ERR(0, 577, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_11, __pyx_n_s_np); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 577, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_t_11, __pyx_n_s_zeros); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 577, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
  __pyx_t_11 = __Pyx_PyInt_From_npy_int64(__pyx_v_chrom_max_len); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 577, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 577, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_11);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_11);
  __pyx_t_11 = 0;
  __pyx_t_11 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 577, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  if (PyDict_SetItem(__pyx_t_11, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 577, __pyx_L1_error)
  __pyx_t_2 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_3, __pyx_t_11); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 577, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
  if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 577, __pyx_L1_error)
  __pyx_t_10 = ((PyArrayObject *)__pyx_t_2);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_t.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ret_t.rcbuffer->pybuffer, (PyObject*)__pyx_t_10, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_8, &__pyx_t_7);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ret_t.rcbuffer->pybuffer, (PyObject*)__pyx_v_ret_t, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_7);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_8, __pyx_t_7);
      }
      __pyx_t_9 = __pyx_t_8 = __pyx_t_7 = 0;
    }
    __pyx_pybuffernd_ret_t.diminfo[0].strides = __pyx_pybuffernd_ret_t.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_ret_t.diminfo[0].shape = __pyx_pybuffernd_ret_t.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 577, __pyx_L1_error)
  }
  __pyx_t_10 = 0;
  __pyx_v_ret_t = ((PyArrayObject *)__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":578
 *         ret_p = np.zeros( chrom_max_len, dtype="int32" ) # position
 *         ret_t = np.zeros( chrom_max_len, dtype="float32" ) # value from treatment
 *         ret_c = np.zeros( chrom_max_len, dtype="float32" ) # value from control             # <<<<<<<<<<<<<<
 * 
 *         t_p_ptr = <int32_t *> t_p.data
 */
  __Pyx_TraceLine(578,0,__PYX_ERR(0, 578, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_np); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 578, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_11 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_zeros); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 578, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyInt_From_npy_int64(__pyx_v_chrom_max_len); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 578, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 578, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 578, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 578, __pyx_L1_error)
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_11, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 578, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 578, __pyx_L1_error)
  __pyx_t_10 = ((PyArrayObject *)__pyx_t_1);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_c.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ret_c.rcbuffer->pybuffer, (PyObject*)__pyx_t_10, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ret_c.rcbuffer->pybuffer, (PyObject*)__pyx_v_ret_c, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_ret_c.diminfo[0].strides = __pyx_pybuffernd_ret_c.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_ret_c.diminfo[0].shape = __pyx_pybuffernd_ret_c.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 578, __pyx_L1_error)
  }
  __pyx_t_10 = 0;
  __pyx_v_ret_c = ((PyArrayObject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":580
 *         ret_c = np.zeros( chrom_max_len, dtype="float32" ) # value from control
 * 
 *         t_p_ptr = <int32_t *> t_p.data             # <<<<<<<<<<<<<<
 *         t_v_ptr = <float32_t *> t_v.data
 *         c_p_ptr = <int32_t *> c_p.data
 */
  __Pyx_TraceLine(580,0,__PYX_ERR(0, 580, __pyx_L1_error))
  __pyx_v_t_p_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_t_p->data);

  /* "MACS2/IO/CallPeakUnit.pyx":581
 * 
 *         t_p_ptr = <int32_t *> t_p.data
 *         t_v_ptr = <float32_t *> t_v.data             # <<<<<<<<<<<<<<
 *         c_p_ptr = <int32_t *> c_p.data
 *         c_v_ptr = <float32_t *> c_v.data
 */
  __Pyx_TraceLine(581,0,__PYX_ERR(0, 581, __pyx_L1_error))
  __pyx_v_t_v_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_t_v->data);

  /* "MACS2/IO/CallPeakUnit.pyx":582
 *         t_p_ptr = <int32_t *> t_p.data
 *         t_v_ptr = <float32_t *> t_v.data
 *         c_p_ptr = <int32_t *> c_p.data             # <<<<<<<<<<<<<<
 *         c_v_ptr = <float32_t *> c_v.data
 *         ret_p_ptr = <int32_t *> ret_p.data
 */
  __Pyx_TraceLine(582,0,__PYX_ERR(0, 582, __pyx_L1_error))
  __pyx_v_c_p_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_c_p->data);

  /* "MACS2/IO/CallPeakUnit.pyx":583
 *         t_v_ptr = <float32_t *> t_v.data
 *         c_p_ptr = <int32_t *> c_p.data
 *         c_v_ptr = <float32_t *> c_v.data             # <<<<<<<<<<<<<<
 *         ret_p_ptr = <int32_t *> ret_p.data
 *         ret_t_ptr = <float32_t *>ret_t.data
 */
  __Pyx_TraceLine(583,0,__PYX_ERR(0, 583, __pyx_L1_error))
  __pyx_v_c_v_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_c_v->data);

  /* "MACS2/IO/CallPeakUnit.pyx":584
 *         c_p_ptr = <int32_t *> c_p.data
 *         c_v_ptr = <float32_t *> c_v.data
 *         ret_p_ptr = <int32_t *> ret_p.data             # <<<<<<<<<<<<<<
 *         ret_t_ptr = <float32_t *>ret_t.data
 *         ret_c_ptr = <float32_t *>ret_c.data
 */
  __Pyx_TraceLine(584,0,__PYX_ERR(0, 584, __pyx_L1_error))
  __pyx_v_ret_p_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_ret_p->data);

  /* "MACS2/IO/CallPeakUnit.pyx":585
 *         c_v_ptr = <float32_t *> c_v.data
 *         ret_p_ptr = <int32_t *> ret_p.data
 *         ret_t_ptr = <float32_t *>ret_t.data             # <<<<<<<<<<<<<<
 *         ret_c_ptr = <float32_t *>ret_c.data
 * 
 */
  __Pyx_TraceLine(585,0,__PYX_ERR(0, 585, __pyx_L1_error))
  __pyx_v_ret_t_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_ret_t->data);

  /* "MACS2/IO/CallPeakUnit.pyx":586
 *         ret_p_ptr = <int32_t *> ret_p.data
 *         ret_t_ptr = <float32_t *>ret_t.data
 *         ret_c_ptr = <float32_t *>ret_c.data             # <<<<<<<<<<<<<<
 * 
 *         pre_p = 0
 */
  __Pyx_TraceLine(586,0,__PYX_ERR(0, 586, __pyx_L1_error))
  __pyx_v_ret_c_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_ret_c->data);

  /* "MACS2/IO/CallPeakUnit.pyx":588
 *         ret_c_ptr = <float32_t *>ret_c.data
 * 
 *         pre_p = 0             # <<<<<<<<<<<<<<
 *         index_ret = 0
 *         it = 0
 */
  __Pyx_TraceLine(588,0,__PYX_ERR(0, 588, __pyx_L1_error))
  __pyx_v_pre_p = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":589
 * 
 *         pre_p = 0
 *         index_ret = 0             # <<<<<<<<<<<<<<
 *         it = 0
 *         ic = 0
 */
  __Pyx_TraceLine(589,0,__PYX_ERR(0, 589, __pyx_L1_error))
  __pyx_v_index_ret = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":590
 *         pre_p = 0
 *         index_ret = 0
 *         it = 0             # <<<<<<<<<<<<<<
 *         ic = 0
 * 
 */
  __Pyx_TraceLine(590,0,__PYX_ERR(0, 590, __pyx_L1_error))
  __pyx_v_it = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":591
 *         index_ret = 0
 *         it = 0
 *         ic = 0             # <<<<<<<<<<<<<<
 * 
 *         while it < lt and ic < lc:
 */
  __Pyx_TraceLine(591,0,__PYX_ERR(0, 591, __pyx_L1_error))
  __pyx_v_ic = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":593
 *         ic = 0
 * 
 *         while it < lt and ic < lc:             # <<<<<<<<<<<<<<
 *             if t_p_ptr[0] < c_p_ptr[0]:
 *                 # clip a region from pre_p to p1, then set pre_p as p1.
 */
  __Pyx_TraceLine(593,0,__PYX_ERR(0, 593, __pyx_L1_error))
  while (1) {
    __pyx_t_13 = ((__pyx_v_it < __pyx_v_lt) != 0);
    if (__pyx_t_13) {
    } else {
      __pyx_t_12 = __pyx_t_13;
      goto __pyx_L9_bool_binop_done;
    }
    __pyx_t_13 = ((__pyx_v_ic < __pyx_v_lc) != 0);
    __pyx_t_12 = __pyx_t_13;
    __pyx_L9_bool_binop_done:;
    if (!__pyx_t_12) break;

    /* "MACS2/IO/CallPeakUnit.pyx":594
 * 
 *         while it < lt and ic < lc:
 *             if t_p_ptr[0] < c_p_ptr[0]:             # <<<<<<<<<<<<<<
 *                 # clip a region from pre_p to p1, then set pre_p as p1.
 *                 ret_p_ptr[0] = t_p_ptr[0]
 */
    __Pyx_TraceLine(594,0,__PYX_ERR(0, 594, __pyx_L1_error))
    __pyx_t_12 = (((__pyx_v_t_p_ptr[0]) < (__pyx_v_c_p_ptr[0])) != 0);
    if (__pyx_t_12) {

      /* "MACS2/IO/CallPeakUnit.pyx":596
 *             if t_p_ptr[0] < c_p_ptr[0]:
 *                 # clip a region from pre_p to p1, then set pre_p as p1.
 *                 ret_p_ptr[0] = t_p_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]
 */
      __Pyx_TraceLine(596,0,__PYX_ERR(0, 596, __pyx_L1_error))
      (__pyx_v_ret_p_ptr[0]) = (__pyx_v_t_p_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":597
 *                 # clip a region from pre_p to p1, then set pre_p as p1.
 *                 ret_p_ptr[0] = t_p_ptr[0]
 *                 ret_t_ptr[0] = t_v_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1
 */
      __Pyx_TraceLine(597,0,__PYX_ERR(0, 597, __pyx_L1_error))
      (__pyx_v_ret_t_ptr[0]) = (__pyx_v_t_v_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":598
 *                 ret_p_ptr[0] = t_p_ptr[0]
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1
 */
      __Pyx_TraceLine(598,0,__PYX_ERR(0, 598, __pyx_L1_error))
      (__pyx_v_ret_c_ptr[0]) = (__pyx_v_c_v_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":599
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1             # <<<<<<<<<<<<<<
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1
 */
      __Pyx_TraceLine(599,0,__PYX_ERR(0, 599, __pyx_L1_error))
      __pyx_v_ret_p_ptr = (__pyx_v_ret_p_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":600
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1             # <<<<<<<<<<<<<<
 *                 ret_c_ptr += 1
 *                 pre_p = t_p_ptr[0]
 */
      __Pyx_TraceLine(600,0,__PYX_ERR(0, 600, __pyx_L1_error))
      __pyx_v_ret_t_ptr = (__pyx_v_ret_t_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":601
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1             # <<<<<<<<<<<<<<
 *                 pre_p = t_p_ptr[0]
 *                 index_ret += 1
 */
      __Pyx_TraceLine(601,0,__PYX_ERR(0, 601, __pyx_L1_error))
      __pyx_v_ret_c_ptr = (__pyx_v_ret_c_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":602
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1
 *                 pre_p = t_p_ptr[0]             # <<<<<<<<<<<<<<
 *                 index_ret += 1
 *                 # call for the next p1 and v1
 */
      __Pyx_TraceLine(602,0,__PYX_ERR(0, 602, __pyx_L1_error))
      __pyx_v_pre_p = (__pyx_v_t_p_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":603
 *                 ret_c_ptr += 1
 *                 pre_p = t_p_ptr[0]
 *                 index_ret += 1             # <<<<<<<<<<<<<<
 *                 # call for the next p1 and v1
 *                 it += 1
 */
      __Pyx_TraceLine(603,0,__PYX_ERR(0, 603, __pyx_L1_error))
      __pyx_v_index_ret = (__pyx_v_index_ret + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":605
 *                 index_ret += 1
 *                 # call for the next p1 and v1
 *                 it += 1             # <<<<<<<<<<<<<<
 *                 t_p_ptr += 1
 *                 t_v_ptr += 1
 */
      __Pyx_TraceLine(605,0,__PYX_ERR(0, 605, __pyx_L1_error))
      __pyx_v_it = (__pyx_v_it + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":606
 *                 # call for the next p1 and v1
 *                 it += 1
 *                 t_p_ptr += 1             # <<<<<<<<<<<<<<
 *                 t_v_ptr += 1
 *             elif t_p_ptr[0] > c_p_ptr[0]:
 */
      __Pyx_TraceLine(606,0,__PYX_ERR(0, 606, __pyx_L1_error))
      __pyx_v_t_p_ptr = (__pyx_v_t_p_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":607
 *                 it += 1
 *                 t_p_ptr += 1
 *                 t_v_ptr += 1             # <<<<<<<<<<<<<<
 *             elif t_p_ptr[0] > c_p_ptr[0]:
 *                 # clip a region from pre_p to p2, then set pre_p as p2.
 */
      __Pyx_TraceLine(607,0,__PYX_ERR(0, 607, __pyx_L1_error))
      __pyx_v_t_v_ptr = (__pyx_v_t_v_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":594
 * 
 *         while it < lt and ic < lc:
 *             if t_p_ptr[0] < c_p_ptr[0]:             # <<<<<<<<<<<<<<
 *                 # clip a region from pre_p to p1, then set pre_p as p1.
 *                 ret_p_ptr[0] = t_p_ptr[0]
 */
      goto __pyx_L11;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":608
 *                 t_p_ptr += 1
 *                 t_v_ptr += 1
 *             elif t_p_ptr[0] > c_p_ptr[0]:             # <<<<<<<<<<<<<<
 *                 # clip a region from pre_p to p2, then set pre_p as p2.
 *                 ret_p_ptr[0] = c_p_ptr[0]
 */
    __Pyx_TraceLine(608,0,__PYX_ERR(0, 608, __pyx_L1_error))
    __pyx_t_12 = (((__pyx_v_t_p_ptr[0]) > (__pyx_v_c_p_ptr[0])) != 0);
    if (__pyx_t_12) {

      /* "MACS2/IO/CallPeakUnit.pyx":610
 *             elif t_p_ptr[0] > c_p_ptr[0]:
 *                 # clip a region from pre_p to p2, then set pre_p as p2.
 *                 ret_p_ptr[0] = c_p_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]
 */
      __Pyx_TraceLine(610,0,__PYX_ERR(0, 610, __pyx_L1_error))
      (__pyx_v_ret_p_ptr[0]) = (__pyx_v_c_p_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":611
 *                 # clip a region from pre_p to p2, then set pre_p as p2.
 *                 ret_p_ptr[0] = c_p_ptr[0]
 *                 ret_t_ptr[0] = t_v_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1
 */
      __Pyx_TraceLine(611,0,__PYX_ERR(0, 611, __pyx_L1_error))
      (__pyx_v_ret_t_ptr[0]) = (__pyx_v_t_v_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":612
 *                 ret_p_ptr[0] = c_p_ptr[0]
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1
 */
      __Pyx_TraceLine(612,0,__PYX_ERR(0, 612, __pyx_L1_error))
      (__pyx_v_ret_c_ptr[0]) = (__pyx_v_c_v_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":613
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1             # <<<<<<<<<<<<<<
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1
 */
      __Pyx_TraceLine(613,0,__PYX_ERR(0, 613, __pyx_L1_error))
      __pyx_v_ret_p_ptr = (__pyx_v_ret_p_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":614
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1             # <<<<<<<<<<<<<<
 *                 ret_c_ptr += 1
 *                 pre_p = c_p_ptr[0]
 */
      __Pyx_TraceLine(614,0,__PYX_ERR(0, 614, __pyx_L1_error))
      __pyx_v_ret_t_ptr = (__pyx_v_ret_t_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":615
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1             # <<<<<<<<<<<<<<
 *                 pre_p = c_p_ptr[0]
 *                 index_ret += 1
 */
      __Pyx_TraceLine(615,0,__PYX_ERR(0, 615, __pyx_L1_error))
      __pyx_v_ret_c_ptr = (__pyx_v_ret_c_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":616
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1
 *                 pre_p = c_p_ptr[0]             # <<<<<<<<<<<<<<
 *                 index_ret += 1
 *                 # call for the next p2 and v2
 */
      __Pyx_TraceLine(616,0,__PYX_ERR(0, 616, __pyx_L1_error))
      __pyx_v_pre_p = (__pyx_v_c_p_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":617
 *                 ret_c_ptr += 1
 *                 pre_p = c_p_ptr[0]
 *                 index_ret += 1             # <<<<<<<<<<<<<<
 *                 # call for the next p2 and v2
 *                 ic += 1
 */
      __Pyx_TraceLine(617,0,__PYX_ERR(0, 617, __pyx_L1_error))
      __pyx_v_index_ret = (__pyx_v_index_ret + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":619
 *                 index_ret += 1
 *                 # call for the next p2 and v2
 *                 ic += 1             # <<<<<<<<<<<<<<
 *                 c_p_ptr += 1
 *                 c_v_ptr += 1
 */
      __Pyx_TraceLine(619,0,__PYX_ERR(0, 619, __pyx_L1_error))
      __pyx_v_ic = (__pyx_v_ic + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":620
 *                 # call for the next p2 and v2
 *                 ic += 1
 *                 c_p_ptr += 1             # <<<<<<<<<<<<<<
 *                 c_v_ptr += 1
 *             else:
 */
      __Pyx_TraceLine(620,0,__PYX_ERR(0, 620, __pyx_L1_error))
      __pyx_v_c_p_ptr = (__pyx_v_c_p_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":621
 *                 ic += 1
 *                 c_p_ptr += 1
 *                 c_v_ptr += 1             # <<<<<<<<<<<<<<
 *             else:
 *                 # from pre_p to p1 or p2, then set pre_p as p1 or p2.
 */
      __Pyx_TraceLine(621,0,__PYX_ERR(0, 621, __pyx_L1_error))
      __pyx_v_c_v_ptr = (__pyx_v_c_v_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":608
 *                 t_p_ptr += 1
 *                 t_v_ptr += 1
 *             elif t_p_ptr[0] > c_p_ptr[0]:             # <<<<<<<<<<<<<<
 *                 # clip a region from pre_p to p2, then set pre_p as p2.
 *                 ret_p_ptr[0] = c_p_ptr[0]
 */
      goto __pyx_L11;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":624
 *             else:
 *                 # from pre_p to p1 or p2, then set pre_p as p1 or p2.
 *                 ret_p_ptr[0] = t_p_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]
 */
    __Pyx_TraceLine(624,0,__PYX_ERR(0, 624, __pyx_L1_error))
    /*else*/ {
      (__pyx_v_ret_p_ptr[0]) = (__pyx_v_t_p_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":625
 *                 # from pre_p to p1 or p2, then set pre_p as p1 or p2.
 *                 ret_p_ptr[0] = t_p_ptr[0]
 *                 ret_t_ptr[0] = t_v_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1
 */
      __Pyx_TraceLine(625,0,__PYX_ERR(0, 625, __pyx_L1_error))
      (__pyx_v_ret_t_ptr[0]) = (__pyx_v_t_v_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":626
 *                 ret_p_ptr[0] = t_p_ptr[0]
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]             # <<<<<<<<<<<<<<
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1
 */
      __Pyx_TraceLine(626,0,__PYX_ERR(0, 626, __pyx_L1_error))
      (__pyx_v_ret_c_ptr[0]) = (__pyx_v_c_v_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":627
 *                 ret_t_ptr[0] = t_v_ptr[0]
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1             # <<<<<<<<<<<<<<
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1
 */
      __Pyx_TraceLine(627,0,__PYX_ERR(0, 627, __pyx_L1_error))
      __pyx_v_ret_p_ptr = (__pyx_v_ret_p_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":628
 *                 ret_c_ptr[0] = c_v_ptr[0]
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1             # <<<<<<<<<<<<<<
 *                 ret_c_ptr += 1
 *                 pre_p = t_p_ptr[0]
 */
      __Pyx_TraceLine(628,0,__PYX_ERR(0, 628, __pyx_L1_error))
      __pyx_v_ret_t_ptr = (__pyx_v_ret_t_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":629
 *                 ret_p_ptr += 1
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1             # <<<<<<<<<<<<<<
 *                 pre_p = t_p_ptr[0]
 *                 index_ret += 1
 */
      __Pyx_TraceLine(629,0,__PYX_ERR(0, 629, __pyx_L1_error))
      __pyx_v_ret_c_ptr = (__pyx_v_ret_c_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":630
 *                 ret_t_ptr += 1
 *                 ret_c_ptr += 1
 *                 pre_p = t_p_ptr[0]             # <<<<<<<<<<<<<<
 *                 index_ret += 1
 *                 # call for the next p1, v1, p2, v2.
 */
      __Pyx_TraceLine(630,0,__PYX_ERR(0, 630, __pyx_L1_error))
      __pyx_v_pre_p = (__pyx_v_t_p_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":631
 *                 ret_c_ptr += 1
 *                 pre_p = t_p_ptr[0]
 *                 index_ret += 1             # <<<<<<<<<<<<<<
 *                 # call for the next p1, v1, p2, v2.
 *                 it += 1
 */
      __Pyx_TraceLine(631,0,__PYX_ERR(0, 631, __pyx_L1_error))
      __pyx_v_index_ret = (__pyx_v_index_ret + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":633
 *                 index_ret += 1
 *                 # call for the next p1, v1, p2, v2.
 *                 it += 1             # <<<<<<<<<<<<<<
 *                 ic += 1
 *                 t_p_ptr += 1
 */
      __Pyx_TraceLine(633,0,__PYX_ERR(0, 633, __pyx_L1_error))
      __pyx_v_it = (__pyx_v_it + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":634
 *                 # call for the next p1, v1, p2, v2.
 *                 it += 1
 *                 ic += 1             # <<<<<<<<<<<<<<
 *                 t_p_ptr += 1
 *                 t_v_ptr += 1
 */
      __Pyx_TraceLine(634,0,__PYX_ERR(0, 634, __pyx_L1_error))
      __pyx_v_ic = (__pyx_v_ic + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":635
 *                 it += 1
 *                 ic += 1
 *                 t_p_ptr += 1             # <<<<<<<<<<<<<<
 *                 t_v_ptr += 1
 *                 c_p_ptr += 1
 */
      __Pyx_TraceLine(635,0,__PYX_ERR(0, 635, __pyx_L1_error))
      __pyx_v_t_p_ptr = (__pyx_v_t_p_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":636
 *                 ic += 1
 *                 t_p_ptr += 1
 *                 t_v_ptr += 1             # <<<<<<<<<<<<<<
 *                 c_p_ptr += 1
 *                 c_v_ptr += 1
 */
      __Pyx_TraceLine(636,0,__PYX_ERR(0, 636, __pyx_L1_error))
      __pyx_v_t_v_ptr = (__pyx_v_t_v_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":637
 *                 t_p_ptr += 1
 *                 t_v_ptr += 1
 *                 c_p_ptr += 1             # <<<<<<<<<<<<<<
 *                 c_v_ptr += 1
 * 
 */
      __Pyx_TraceLine(637,0,__PYX_ERR(0, 637, __pyx_L1_error))
      __pyx_v_c_p_ptr = (__pyx_v_c_p_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":638
 *                 t_v_ptr += 1
 *                 c_p_ptr += 1
 *                 c_v_ptr += 1             # <<<<<<<<<<<<<<
 * 
 *         ret_p.resize( index_ret, refcheck=False)
 */
      __Pyx_TraceLine(638,0,__PYX_ERR(0, 638, __pyx_L1_error))
      __pyx_v_c_v_ptr = (__pyx_v_c_v_ptr + 1);
    }
    __pyx_L11:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":640
 *                 c_v_ptr += 1
 * 
 *         ret_p.resize( index_ret, refcheck=False)             # <<<<<<<<<<<<<<
 *         ret_t.resize( index_ret, refcheck=False)
 *         ret_c.resize( index_ret, refcheck=False)
 */
  __Pyx_TraceLine(640,0,__PYX_ERR(0, 640, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_ret_p), __pyx_n_s_resize); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 640, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyInt_From_npy_int64(__pyx_v_index_ret); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 640, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 640, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 640, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_refcheck, Py_False) < 0) __PYX_ERR(0, 640, __pyx_L1_error)
  __pyx_t_11 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 640, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":641
 * 
 *         ret_p.resize( index_ret, refcheck=False)
 *         ret_t.resize( index_ret, refcheck=False)             # <<<<<<<<<<<<<<
 *         ret_c.resize( index_ret, refcheck=False)
 *         return [ret_p, ret_t, ret_c]
 */
  __Pyx_TraceLine(641,0,__PYX_ERR(0, 641, __pyx_L1_error))
  __pyx_t_11 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_ret_t), __pyx_n_s_resize); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 641, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __pyx_t_2 = __Pyx_PyInt_From_npy_int64(__pyx_v_index_ret); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 641, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 641, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 641, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_refcheck, Py_False) < 0) __PYX_ERR(0, 641, __pyx_L1_error)
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_11, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 641, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":642
 *         ret_p.resize( index_ret, refcheck=False)
 *         ret_t.resize( index_ret, refcheck=False)
 *         ret_c.resize( index_ret, refcheck=False)             # <<<<<<<<<<<<<<
 *         return [ret_p, ret_t, ret_c]
 * 
 */
  __Pyx_TraceLine(642,0,__PYX_ERR(0, 642, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_ret_c), __pyx_n_s_resize); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyInt_From_npy_int64(__pyx_v_index_ret); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_refcheck, Py_False) < 0) __PYX_ERR(0, 642, __pyx_L1_error)
  __pyx_t_11 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":643
 *         ret_t.resize( index_ret, refcheck=False)
 *         ret_c.resize( index_ret, refcheck=False)
 *         return [ret_p, ret_t, ret_c]             # <<<<<<<<<<<<<<
 * 
 *     cdef np.ndarray __cal_score ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2, cal_func ):
 */
  __Pyx_TraceLine(643,0,__PYX_ERR(0, 643, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_11 = PyList_New(3); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 643, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_11);
  __Pyx_INCREF(((PyObject *)__pyx_v_ret_p));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_ret_p));
  PyList_SET_ITEM(__pyx_t_11, 0, ((PyObject *)__pyx_v_ret_p));
  __Pyx_INCREF(((PyObject *)__pyx_v_ret_t));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_ret_t));
  PyList_SET_ITEM(__pyx_t_11, 1, ((PyObject *)__pyx_v_ret_t));
  __Pyx_INCREF(((PyObject *)__pyx_v_ret_c));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_ret_c));
  PyList_SET_ITEM(__pyx_t_11, 2, ((PyObject *)__pyx_v_ret_c));
  __pyx_r = ((PyObject*)__pyx_t_11);
  __pyx_t_11 = 0;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":546
 *         return
 * 
 *     cdef list __chrom_pair_treat_ctrl ( self, treat_pv, ctrl_pv ):             # <<<<<<<<<<<<<<
 *         """*private* Pair treat and ctrl pileup for each region.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_11);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_c_p.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_c_v.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_c.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_p.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_t.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_t_p.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_t_v.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__chrom_pair_treat_ctrl", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_c_p.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_c_v.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_c.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_p.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ret_t.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_t_p.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_t_v.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_t_p);
  __Pyx_XDECREF((PyObject *)__pyx_v_c_p);
  __Pyx_XDECREF((PyObject *)__pyx_v_ret_p);
  __Pyx_XDECREF((PyObject *)__pyx_v_t_v);
  __Pyx_XDECREF((PyObject *)__pyx_v_c_v);
  __Pyx_XDECREF((PyObject *)__pyx_v_ret_t);
  __Pyx_XDECREF((PyObject *)__pyx_v_ret_c);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":645
 *         return [ret_p, ret_t, ret_c]
 * 
 *     cdef np.ndarray __cal_score ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2, cal_func ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i
 */

static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_score(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2, PyObject *__pyx_v_cal_func) {
  __pyx_t_5numpy_int64_t __pyx_v_i;
  PyArrayObject *__pyx_v_s = 0;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array1;
  __Pyx_Buffer __pyx_pybuffer_array1;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array2;
  __Pyx_Buffer __pyx_pybuffer_array2;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_s;
  __Pyx_Buffer __pyx_pybuffer_s;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  npy_intp __pyx_t_10;
  npy_intp __pyx_t_11;
  __pyx_t_5numpy_int64_t __pyx_t_12;
  __pyx_t_5numpy_int64_t __pyx_t_13;
  __pyx_t_5numpy_int64_t __pyx_t_14;
  PyObject *__pyx_t_15 = NULL;
  PyObject *__pyx_t_16 = NULL;
  __pyx_t_5numpy_float32_t __pyx_t_17;
  __pyx_t_5numpy_int64_t __pyx_t_18;
  __Pyx_RefNannySetupContext("__cal_score", 0);
  __Pyx_TraceCall("__cal_score", __pyx_f[0], 645, 0, __PYX_ERR(0, 645, __pyx_L1_error));
  __pyx_pybuffer_s.pybuffer.buf = NULL;
  __pyx_pybuffer_s.refcount = 0;
  __pyx_pybuffernd_s.data = NULL;
  __pyx_pybuffernd_s.rcbuffer = &__pyx_pybuffer_s;
  __pyx_pybuffer_array1.pybuffer.buf = NULL;
  __pyx_pybuffer_array1.refcount = 0;
  __pyx_pybuffernd_array1.data = NULL;
  __pyx_pybuffernd_array1.rcbuffer = &__pyx_pybuffer_array1;
  __pyx_pybuffer_array2.pybuffer.buf = NULL;
  __pyx_pybuffer_array2.refcount = 0;
  __pyx_pybuffernd_array2.data = NULL;
  __pyx_pybuffernd_array2.rcbuffer = &__pyx_pybuffer_array2;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array1.rcbuffer->pybuffer, (PyObject*)__pyx_v_array1, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 645, __pyx_L1_error)
  }
  __pyx_pybuffernd_array1.diminfo[0].strides = __pyx_pybuffernd_array1.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array1.diminfo[0].shape = __pyx_pybuffernd_array1.rcbuffer->pybuffer.shape[0];
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array2.rcbuffer->pybuffer, (PyObject*)__pyx_v_array2, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 645, __pyx_L1_error)
  }
  __pyx_pybuffernd_array2.diminfo[0].strides = __pyx_pybuffernd_array2.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array2.diminfo[0].shape = __pyx_pybuffernd_array2.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":649
 *             int64_t i
 *             np.ndarray[np.float32_t, ndim=1] s
 *         assert array1.shape[0] == array2.shape[0]             # <<<<<<<<<<<<<<
 *         s = np.zeros(array1.shape[0], dtype="float32")
 *         for i in range(array1.shape[0]):
 */
  __Pyx_TraceLine(649,0,__PYX_ERR(0, 649, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(!(((__pyx_v_array1->dimensions[0]) == (__pyx_v_array2->dimensions[0])) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 649, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":650
 *             np.ndarray[np.float32_t, ndim=1] s
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")             # <<<<<<<<<<<<<<
 *         for i in range(array1.shape[0]):
 *             s[i] = cal_func( array1[i], array2[i] )
 */
  __Pyx_TraceLine(650,0,__PYX_ERR(0, 650, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 650, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 650, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_array1->dimensions[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 650, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 650, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 650, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 650, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 650, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 650, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES| PyBUF_WRITABLE, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_v_s, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES| PyBUF_WRITABLE, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_s.diminfo[0].strides = __pyx_pybuffernd_s.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_s.diminfo[0].shape = __pyx_pybuffernd_s.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 650, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_s = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":651
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")
 *         for i in range(array1.shape[0]):             # <<<<<<<<<<<<<<
 *             s[i] = cal_func( array1[i], array2[i] )
 *         return s
 */
  __Pyx_TraceLine(651,0,__PYX_ERR(0, 651, __pyx_L1_error))
  __pyx_t_10 = (__pyx_v_array1->dimensions[0]);
  __pyx_t_11 = __pyx_t_10;
  for (__pyx_t_12 = 0; __pyx_t_12 < __pyx_t_11; __pyx_t_12+=1) {
    __pyx_v_i = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":652
 *         s = np.zeros(array1.shape[0], dtype="float32")
 *         for i in range(array1.shape[0]):
 *             s[i] = cal_func( array1[i], array2[i] )             # <<<<<<<<<<<<<<
 *         return s
 * 
 */
    __Pyx_TraceLine(652,0,__PYX_ERR(0, 652, __pyx_L1_error))
    __pyx_t_13 = __pyx_v_i;
    __pyx_t_6 = -1;
    if (__pyx_t_13 < 0) {
      __pyx_t_13 += __pyx_pybuffernd_array1.diminfo[0].shape;
      if (unlikely(__pyx_t_13 < 0)) __pyx_t_6 = 0;
    } else if (unlikely(__pyx_t_13 >= __pyx_pybuffernd_array1.diminfo[0].shape)) __pyx_t_6 = 0;
    if (unlikely(__pyx_t_6 != -1)) {
      __Pyx_RaiseBufferIndexError(__pyx_t_6);
      __PYX_ERR(0, 652, __pyx_L1_error)
    }
    __pyx_t_1 = PyFloat_FromDouble((*__Pyx_BufPtrStrided1d(__pyx_t_5numpy_float32_t *, __pyx_pybuffernd_array1.rcbuffer->pybuffer.buf, __pyx_t_13, __pyx_pybuffernd_array1.diminfo[0].strides))); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 652, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_14 = __pyx_v_i;
    __pyx_t_6 = -1;
    if (__pyx_t_14 < 0) {
      __pyx_t_14 += __pyx_pybuffernd_array2.diminfo[0].shape;
      if (unlikely(__pyx_t_14 < 0)) __pyx_t_6 = 0;
    } else if (unlikely(__pyx_t_14 >= __pyx_pybuffernd_array2.diminfo[0].shape)) __pyx_t_6 = 0;
    if (unlikely(__pyx_t_6 != -1)) {
      __Pyx_RaiseBufferIndexError(__pyx_t_6);
      __PYX_ERR(0, 652, __pyx_L1_error)
    }
    __pyx_t_3 = PyFloat_FromDouble((*__Pyx_BufPtrStrided1d(__pyx_t_5numpy_float32_t *, __pyx_pybuffernd_array2.rcbuffer->pybuffer.buf, __pyx_t_14, __pyx_pybuffernd_array2.diminfo[0].strides))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 652, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_INCREF(__pyx_v_cal_func);
    __pyx_t_2 = __pyx_v_cal_func; __pyx_t_15 = NULL;
    __pyx_t_6 = 0;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_15 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_15)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_15);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_6 = 1;
      }
    }
    #if CYTHON_FAST_PYCALL
    if (PyFunction_Check(__pyx_t_2)) {
      PyObject *__pyx_temp[3] = {__pyx_t_15, __pyx_t_1, __pyx_t_3};
      __pyx_t_4 = __Pyx_PyFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_6, 2+__pyx_t_6); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 652, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_15); __pyx_t_15 = 0;
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    } else
    #endif
    #if CYTHON_FAST_PYCCALL
    if (__Pyx_PyFastCFunction_Check(__pyx_t_2)) {
      PyObject *__pyx_temp[3] = {__pyx_t_15, __pyx_t_1, __pyx_t_3};
      __pyx_t_4 = __Pyx_PyCFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_6, 2+__pyx_t_6); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 652, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_15); __pyx_t_15 = 0;
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    } else
    #endif
    {
      __pyx_t_16 = PyTuple_New(2+__pyx_t_6); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 652, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_16);
      if (__pyx_t_15) {
        __Pyx_GIVEREF(__pyx_t_15); PyTuple_SET_ITEM(__pyx_t_16, 0, __pyx_t_15); __pyx_t_15 = NULL;
      }
      __Pyx_GIVEREF(__pyx_t_1);
      PyTuple_SET_ITEM(__pyx_t_16, 0+__pyx_t_6, __pyx_t_1);
      __Pyx_GIVEREF(__pyx_t_3);
      PyTuple_SET_ITEM(__pyx_t_16, 1+__pyx_t_6, __pyx_t_3);
      __pyx_t_1 = 0;
      __pyx_t_3 = 0;
      __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_16, NULL); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 652, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    }
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_17 = __pyx_PyFloat_AsFloat(__pyx_t_4); if (unlikely((__pyx_t_17 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 652, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_18 = __pyx_v_i;
    __pyx_t_6 = -1;
    if (__pyx_t_18 < 0) {
      __pyx_t_18 += __pyx_pybuffernd_s.diminfo[0].shape;
      if (unlikely(__pyx_t_18 < 0)) __pyx_t_6 = 0;
    } else if (unlikely(__pyx_t_18 >= __pyx_pybuffernd_s.diminfo[0].shape)) __pyx_t_6 = 0;
    if (unlikely(__pyx_t_6 != -1)) {
      __Pyx_RaiseBufferIndexError(__pyx_t_6);
      __PYX_ERR(0, 652, __pyx_L1_error)
    }
    *__Pyx_BufPtrStrided1d(__pyx_t_5numpy_float32_t *, __pyx_pybuffernd_s.rcbuffer->pybuffer.buf, __pyx_t_18, __pyx_pybuffernd_s.diminfo[0].strides) = __pyx_t_17;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":653
 *         for i in range(array1.shape[0]):
 *             s[i] = cal_func( array1[i], array2[i] )
 *         return s             # <<<<<<<<<<<<<<
 * 
 *     cdef void __cal_pvalue_qvalue_table ( self ):
 */
  __Pyx_TraceLine(653,0,__PYX_ERR(0, 653, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_s));
  __pyx_r = ((PyArrayObject *)__pyx_v_s);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":645
 *         return [ret_p, ret_t, ret_c]
 * 
 *     cdef np.ndarray __cal_score ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2, cal_func ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_15);
  __Pyx_XDECREF(__pyx_t_16);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_score", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_s);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":655
 *         return s
 * 
 *     cdef void __cal_pvalue_qvalue_table ( self ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.pqtable is built. All
 *         chromosomes will be iterated. So it will take some time.
 */

static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_pvalue_qvalue_table(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self) {
  PyObject *__pyx_v_chrom = 0;
  PyArrayObject *__pyx_v_pos_array = 0;
  PyArrayObject *__pyx_v_treat_array = 0;
  PyArrayObject *__pyx_v_ctrl_array = 0;
  PyObject *__pyx_v_pvalue_stat = 0;
  __pyx_t_5numpy_int64_t __pyx_v_pre_p;
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_j;
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_pre_l;
  __pyx_t_5numpy_int64_t __pyx_v_l;
  __pyx_t_5numpy_int64_t __pyx_v_i;
  __pyx_t_5numpy_float32_t __pyx_v_this_v;
  CYTHON_UNUSED __pyx_t_5numpy_float32_t __pyx_v_pre_v;
  __pyx_t_5numpy_float32_t __pyx_v_v;
  __pyx_t_5numpy_float32_t __pyx_v_q;
  __pyx_t_5numpy_float32_t __pyx_v_pre_q;
  __pyx_t_5numpy_int64_t __pyx_v_N;
  __pyx_t_5numpy_int64_t __pyx_v_k;
  __pyx_t_5numpy_int64_t __pyx_v_this_l;
  __pyx_t_5numpy_float32_t __pyx_v_f;
  __pyx_t_5numpy_int64_t __pyx_v_nhcal;
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_npcal;
  PyObject *__pyx_v_unique_values = 0;
  __pyx_t_5numpy_int32_t *__pyx_v_pos_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_treat_value_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_ctrl_value_ptr;
  CYTHON_UNUSED long __pyx_v_nhval;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  Py_ssize_t __pyx_t_4;
  Py_ssize_t __pyx_t_5;
  __pyx_t_5numpy_int64_t __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  npy_intp __pyx_t_8;
  npy_intp __pyx_t_9;
  __pyx_t_5numpy_int64_t __pyx_t_10;
  int __pyx_t_11;
  int __pyx_t_12;
  __pyx_t_5numpy_float32_t __pyx_t_13;
  __pyx_t_5numpy_float32_t __pyx_t_14;
  __pyx_t_5numpy_float32_t __pyx_t_15;
  long __pyx_t_16;
  __Pyx_RefNannySetupContext("__cal_pvalue_qvalue_table", 0);
  __Pyx_TraceCall("__cal_pvalue_qvalue_table", __pyx_f[0], 655, 0, __PYX_ERR(0, 655, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":668
 *             int64_t N, k, this_l
 *             float32_t f
 *             int64_t nhcal = 0             # <<<<<<<<<<<<<<
 *             int64_t npcal = 0
 *             list unique_values
 */
  __Pyx_TraceLine(668,0,__PYX_ERR(0, 668, __pyx_L1_error))
  __pyx_v_nhcal = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":669
 *             float32_t f
 *             int64_t nhcal = 0
 *             int64_t npcal = 0             # <<<<<<<<<<<<<<
 *             list unique_values
 *             float64_t t0, t1, t2, t
 */
  __Pyx_TraceLine(669,0,__PYX_ERR(0, 669, __pyx_L1_error))
  __pyx_v_npcal = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":676
 *             float32_t * ctrl_value_ptr
 * 
 *         logging.debug ( "Start to calculate pvalue stat..." )             # <<<<<<<<<<<<<<
 * 
 *         pvalue_stat = dict()
 */
  __Pyx_TraceLine(676,0,__PYX_ERR(0, 676, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 676, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_debug); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 676, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
    }
  }
  __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_2, __pyx_kp_u_Start_to_calculate_pvalue_stat) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_kp_u_Start_to_calculate_pvalue_stat);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 676, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":678
 *         logging.debug ( "Start to calculate pvalue stat..." )
 * 
 *         pvalue_stat = dict()             # <<<<<<<<<<<<<<
 *         for i in range( len( self.chromosomes ) ):
 *             chrom = self.chromosomes[ i ]
 */
  __Pyx_TraceLine(678,0,__PYX_ERR(0, 678, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 678, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_pvalue_stat = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":679
 * 
 *         pvalue_stat = dict()
 *         for i in range( len( self.chromosomes ) ):             # <<<<<<<<<<<<<<
 *             chrom = self.chromosomes[ i ]
 *             pre_p = 0
 */
  __Pyx_TraceLine(679,0,__PYX_ERR(0, 679, __pyx_L1_error))
  __pyx_t_1 = __pyx_v_self->chromosomes;
  __Pyx_INCREF(__pyx_t_1);
  if (unlikely(__pyx_t_1 == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 679, __pyx_L1_error)
  }
  __pyx_t_4 = PyList_GET_SIZE(__pyx_t_1); if (unlikely(__pyx_t_4 == ((Py_ssize_t)-1))) __PYX_ERR(0, 679, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_5 = __pyx_t_4;
  for (__pyx_t_6 = 0; __pyx_t_6 < __pyx_t_5; __pyx_t_6+=1) {
    __pyx_v_i = __pyx_t_6;

    /* "MACS2/IO/CallPeakUnit.pyx":680
 *         pvalue_stat = dict()
 *         for i in range( len( self.chromosomes ) ):
 *             chrom = self.chromosomes[ i ]             # <<<<<<<<<<<<<<
 *             pre_p = 0
 * 
 */
    __Pyx_TraceLine(680,0,__PYX_ERR(0, 680, __pyx_L1_error))
    if (unlikely(__pyx_v_self->chromosomes == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 680, __pyx_L1_error)
    }
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_self->chromosomes, __pyx_v_i, __pyx_t_5numpy_int64_t, 1, __Pyx_PyInt_From_npy_int64, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 680, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (!(likely(PyBytes_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 680, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_chrom, ((PyObject*)__pyx_t_1));
    __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":681
 *         for i in range( len( self.chromosomes ) ):
 *             chrom = self.chromosomes[ i ]
 *             pre_p = 0             # <<<<<<<<<<<<<<
 * 
 *             self.__pileup_treat_ctrl_a_chromosome( chrom )
 */
    __Pyx_TraceLine(681,0,__PYX_ERR(0, 681, __pyx_L1_error))
    __pyx_v_pre_p = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":683
 *             pre_p = 0
 * 
 *             self.__pileup_treat_ctrl_a_chromosome( chrom )             # <<<<<<<<<<<<<<
 *             [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 * 
 */
    __Pyx_TraceLine(683,0,__PYX_ERR(0, 683, __pyx_L1_error))
    __pyx_t_1 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___pileup_treat_ctrl_a_chromosome(__pyx_v_self, __pyx_v_chrom); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 683, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":684
 * 
 *             self.__pileup_treat_ctrl_a_chromosome( chrom )
 *             [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl             # <<<<<<<<<<<<<<
 * 
 *             pos_ptr = <int32_t *> pos_array.data
 */
    __Pyx_TraceLine(684,0,__PYX_ERR(0, 684, __pyx_L1_error))
    __pyx_t_1 = __pyx_v_self->chr_pos_treat_ctrl;
    __Pyx_INCREF(__pyx_t_1);
    if (likely(__pyx_t_1 != Py_None)) {
      PyObject* sequence = __pyx_t_1;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 3)) {
        if (size > 3) __Pyx_RaiseTooManyValuesError(3);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 684, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      __pyx_t_3 = PyList_GET_ITEM(sequence, 0); 
      __pyx_t_2 = PyList_GET_ITEM(sequence, 1); 
      __pyx_t_7 = PyList_GET_ITEM(sequence, 2); 
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_7);
      #else
      __pyx_t_3 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 684, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_2 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 684, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_7 = PySequence_ITEM(sequence, 2); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 684, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_7);
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    } else {
      __Pyx_RaiseNoneNotIterableError(); __PYX_ERR(0, 684, __pyx_L1_error)
    }
    if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 684, __pyx_L1_error)
    if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 684, __pyx_L1_error)
    if (!(likely(((__pyx_t_7) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_7, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 684, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_pos_array, ((PyArrayObject *)__pyx_t_3));
    __pyx_t_3 = 0;
    __Pyx_XDECREF_SET(__pyx_v_treat_array, ((PyArrayObject *)__pyx_t_2));
    __pyx_t_2 = 0;
    __Pyx_XDECREF_SET(__pyx_v_ctrl_array, ((PyArrayObject *)__pyx_t_7));
    __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":686
 *             [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 * 
 *             pos_ptr = <int32_t *> pos_array.data             # <<<<<<<<<<<<<<
 *             treat_value_ptr = <float32_t *> treat_array.data
 *             ctrl_value_ptr = <float32_t *> ctrl_array.data
 */
    __Pyx_TraceLine(686,0,__PYX_ERR(0, 686, __pyx_L1_error))
    __pyx_v_pos_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_pos_array->data);

    /* "MACS2/IO/CallPeakUnit.pyx":687
 * 
 *             pos_ptr = <int32_t *> pos_array.data
 *             treat_value_ptr = <float32_t *> treat_array.data             # <<<<<<<<<<<<<<
 *             ctrl_value_ptr = <float32_t *> ctrl_array.data
 * 
 */
    __Pyx_TraceLine(687,0,__PYX_ERR(0, 687, __pyx_L1_error))
    __pyx_v_treat_value_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_treat_array->data);

    /* "MACS2/IO/CallPeakUnit.pyx":688
 *             pos_ptr = <int32_t *> pos_array.data
 *             treat_value_ptr = <float32_t *> treat_array.data
 *             ctrl_value_ptr = <float32_t *> ctrl_array.data             # <<<<<<<<<<<<<<
 * 
 *             for j in range(pos_array.shape[0]):
 */
    __Pyx_TraceLine(688,0,__PYX_ERR(0, 688, __pyx_L1_error))
    __pyx_v_ctrl_value_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_ctrl_array->data);

    /* "MACS2/IO/CallPeakUnit.pyx":690
 *             ctrl_value_ptr = <float32_t *> ctrl_array.data
 * 
 *             for j in range(pos_array.shape[0]):             # <<<<<<<<<<<<<<
 *                 #this_v = get_pscore( int(treat_value_ptr[0]), ctrl_value_ptr[0] )
 *                 this_v = get_pscore( (<int32_t>(treat_value_ptr[0]), ctrl_value_ptr[0] ) )
 */
    __Pyx_TraceLine(690,0,__PYX_ERR(0, 690, __pyx_L1_error))
    __pyx_t_8 = (__pyx_v_pos_array->dimensions[0]);
    __pyx_t_9 = __pyx_t_8;
    for (__pyx_t_10 = 0; __pyx_t_10 < __pyx_t_9; __pyx_t_10+=1) {
      __pyx_v_j = __pyx_t_10;

      /* "MACS2/IO/CallPeakUnit.pyx":692
 *             for j in range(pos_array.shape[0]):
 *                 #this_v = get_pscore( int(treat_value_ptr[0]), ctrl_value_ptr[0] )
 *                 this_v = get_pscore( (<int32_t>(treat_value_ptr[0]), ctrl_value_ptr[0] ) )             # <<<<<<<<<<<<<<
 *                 this_l = pos_ptr[0] - pre_p
 * 
 */
      __Pyx_TraceLine(692,0,__PYX_ERR(0, 692, __pyx_L1_error))
      __pyx_t_1 = __Pyx_PyInt_From_npy_int32(((__pyx_t_5numpy_int32_t)(__pyx_v_treat_value_ptr[0]))); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 692, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_7 = PyFloat_FromDouble((__pyx_v_ctrl_value_ptr[0])); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 692, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_7);
      __pyx_t_2 = PyTuple_New(2); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 692, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_GIVEREF(__pyx_t_1);
      PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_t_1);
      __Pyx_GIVEREF(__pyx_t_7);
      PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_t_7);
      __pyx_t_1 = 0;
      __pyx_t_7 = 0;
      __pyx_v_this_v = __pyx_f_5MACS2_2IO_12CallPeakUnit_get_pscore(((PyObject*)__pyx_t_2));
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":693
 *                 #this_v = get_pscore( int(treat_value_ptr[0]), ctrl_value_ptr[0] )
 *                 this_v = get_pscore( (<int32_t>(treat_value_ptr[0]), ctrl_value_ptr[0] ) )
 *                 this_l = pos_ptr[0] - pre_p             # <<<<<<<<<<<<<<
 * 
 *                 if this_v in pvalue_stat:
 */
      __Pyx_TraceLine(693,0,__PYX_ERR(0, 693, __pyx_L1_error))
      __pyx_v_this_l = ((__pyx_v_pos_ptr[0]) - __pyx_v_pre_p);

      /* "MACS2/IO/CallPeakUnit.pyx":695
 *                 this_l = pos_ptr[0] - pre_p
 * 
 *                 if this_v in pvalue_stat:             # <<<<<<<<<<<<<<
 *                     pvalue_stat[ this_v ] += this_l
 *                 else:
 */
      __Pyx_TraceLine(695,0,__PYX_ERR(0, 695, __pyx_L1_error))
      __pyx_t_2 = PyFloat_FromDouble(__pyx_v_this_v); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 695, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_11 = (__Pyx_PyDict_ContainsTF(__pyx_t_2, __pyx_v_pvalue_stat, Py_EQ)); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 695, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_12 = (__pyx_t_11 != 0);
      if (__pyx_t_12) {

        /* "MACS2/IO/CallPeakUnit.pyx":696
 * 
 *                 if this_v in pvalue_stat:
 *                     pvalue_stat[ this_v ] += this_l             # <<<<<<<<<<<<<<
 *                 else:
 *                     pvalue_stat[ this_v ] = this_l
 */
        __Pyx_TraceLine(696,0,__PYX_ERR(0, 696, __pyx_L1_error))
        __pyx_t_2 = PyFloat_FromDouble(__pyx_v_this_v); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 696, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_7 = __Pyx_PyDict_GetItem(__pyx_v_pvalue_stat, __pyx_t_2); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 696, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_7);
        __pyx_t_1 = __Pyx_PyInt_From_npy_int64(__pyx_v_this_l); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 696, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_3 = PyNumber_InPlaceAdd(__pyx_t_7, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 696, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        if (unlikely(PyDict_SetItem(__pyx_v_pvalue_stat, __pyx_t_2, __pyx_t_3) < 0)) __PYX_ERR(0, 696, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":695
 *                 this_l = pos_ptr[0] - pre_p
 * 
 *                 if this_v in pvalue_stat:             # <<<<<<<<<<<<<<
 *                     pvalue_stat[ this_v ] += this_l
 *                 else:
 */
        goto __pyx_L7;
      }

      /* "MACS2/IO/CallPeakUnit.pyx":698
 *                     pvalue_stat[ this_v ] += this_l
 *                 else:
 *                     pvalue_stat[ this_v ] = this_l             # <<<<<<<<<<<<<<
 *                 pre_p = pos_ptr[0]
 *                 pos_ptr += 1
 */
      __Pyx_TraceLine(698,0,__PYX_ERR(0, 698, __pyx_L1_error))
      /*else*/ {
        __pyx_t_2 = __Pyx_PyInt_From_npy_int64(__pyx_v_this_l); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 698, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_3 = PyFloat_FromDouble(__pyx_v_this_v); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 698, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        if (unlikely(PyDict_SetItem(__pyx_v_pvalue_stat, __pyx_t_3, __pyx_t_2) < 0)) __PYX_ERR(0, 698, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      }
      __pyx_L7:;

      /* "MACS2/IO/CallPeakUnit.pyx":699
 *                 else:
 *                     pvalue_stat[ this_v ] = this_l
 *                 pre_p = pos_ptr[0]             # <<<<<<<<<<<<<<
 *                 pos_ptr += 1
 *                 treat_value_ptr += 1
 */
      __Pyx_TraceLine(699,0,__PYX_ERR(0, 699, __pyx_L1_error))
      __pyx_v_pre_p = (__pyx_v_pos_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":700
 *                     pvalue_stat[ this_v ] = this_l
 *                 pre_p = pos_ptr[0]
 *                 pos_ptr += 1             # <<<<<<<<<<<<<<
 *                 treat_value_ptr += 1
 *                 ctrl_value_ptr += 1
 */
      __Pyx_TraceLine(700,0,__PYX_ERR(0, 700, __pyx_L1_error))
      __pyx_v_pos_ptr = (__pyx_v_pos_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":701
 *                 pre_p = pos_ptr[0]
 *                 pos_ptr += 1
 *                 treat_value_ptr += 1             # <<<<<<<<<<<<<<
 *                 ctrl_value_ptr += 1
 * 
 */
      __Pyx_TraceLine(701,0,__PYX_ERR(0, 701, __pyx_L1_error))
      __pyx_v_treat_value_ptr = (__pyx_v_treat_value_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":702
 *                 pos_ptr += 1
 *                 treat_value_ptr += 1
 *                 ctrl_value_ptr += 1             # <<<<<<<<<<<<<<
 * 
 *             nhcal += pos_array.shape[0]
 */
      __Pyx_TraceLine(702,0,__PYX_ERR(0, 702, __pyx_L1_error))
      __pyx_v_ctrl_value_ptr = (__pyx_v_ctrl_value_ptr + 1);
    }

    /* "MACS2/IO/CallPeakUnit.pyx":704
 *                 ctrl_value_ptr += 1
 * 
 *             nhcal += pos_array.shape[0]             # <<<<<<<<<<<<<<
 * 
 *         #logging.debug ( "make pvalue_stat cost %.5f seconds" % t )
 */
    __Pyx_TraceLine(704,0,__PYX_ERR(0, 704, __pyx_L1_error))
    __pyx_v_nhcal = (__pyx_v_nhcal + (__pyx_v_pos_array->dimensions[0]));
  }

  /* "MACS2/IO/CallPeakUnit.pyx":709
 *         #logging.debug ( "calculate pvalue/access hash for %d times" % nhcal )
 *         #logging.debug ( "access hash for %d times" % nhcal )
 *         nhval = 0             # <<<<<<<<<<<<<<
 * 
 *         N = sum(pvalue_stat.values()) # total length
 */
  __Pyx_TraceLine(709,0,__PYX_ERR(0, 709, __pyx_L1_error))
  __pyx_v_nhval = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":711
 *         nhval = 0
 * 
 *         N = sum(pvalue_stat.values()) # total length             # <<<<<<<<<<<<<<
 *         k = 1                           # rank
 *         f = -log10(N)
 */
  __Pyx_TraceLine(711,0,__PYX_ERR(0, 711, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyDict_Values(__pyx_v_pvalue_stat); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 711, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_sum, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 711, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_6 = __Pyx_PyInt_As_npy_int64(__pyx_t_3); if (unlikely((__pyx_t_6 == ((npy_int64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 711, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_N = __pyx_t_6;

  /* "MACS2/IO/CallPeakUnit.pyx":712
 * 
 *         N = sum(pvalue_stat.values()) # total length
 *         k = 1                           # rank             # <<<<<<<<<<<<<<
 *         f = -log10(N)
 *         pre_v = -2147483647
 */
  __Pyx_TraceLine(712,0,__PYX_ERR(0, 712, __pyx_L1_error))
  __pyx_v_k = 1;

  /* "MACS2/IO/CallPeakUnit.pyx":713
 *         N = sum(pvalue_stat.values()) # total length
 *         k = 1                           # rank
 *         f = -log10(N)             # <<<<<<<<<<<<<<
 *         pre_v = -2147483647
 *         pre_l = 0
 */
  __Pyx_TraceLine(713,0,__PYX_ERR(0, 713, __pyx_L1_error))
  __pyx_v_f = (-log10(__pyx_v_N));

  /* "MACS2/IO/CallPeakUnit.pyx":714
 *         k = 1                           # rank
 *         f = -log10(N)
 *         pre_v = -2147483647             # <<<<<<<<<<<<<<
 *         pre_l = 0
 *         pre_q = 2147483647              # save the previous q-value
 */
  __Pyx_TraceLine(714,0,__PYX_ERR(0, 714, __pyx_L1_error))
  __pyx_v_pre_v = -2147483647.0;

  /* "MACS2/IO/CallPeakUnit.pyx":715
 *         f = -log10(N)
 *         pre_v = -2147483647
 *         pre_l = 0             # <<<<<<<<<<<<<<
 *         pre_q = 2147483647              # save the previous q-value
 * 
 */
  __Pyx_TraceLine(715,0,__PYX_ERR(0, 715, __pyx_L1_error))
  __pyx_v_pre_l = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":716
 *         pre_v = -2147483647
 *         pre_l = 0
 *         pre_q = 2147483647              # save the previous q-value             # <<<<<<<<<<<<<<
 * 
 *         self.pqtable = {}
 */
  __Pyx_TraceLine(716,0,__PYX_ERR(0, 716, __pyx_L1_error))
  __pyx_v_pre_q = 2147483647.0;

  /* "MACS2/IO/CallPeakUnit.pyx":718
 *         pre_q = 2147483647              # save the previous q-value
 * 
 *         self.pqtable = {}             # <<<<<<<<<<<<<<
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)
 *         for i in range(len(unique_values)):
 */
  __Pyx_TraceLine(718,0,__PYX_ERR(0, 718, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 718, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_3);
  __Pyx_GOTREF(__pyx_v_self->pqtable);
  __Pyx_DECREF(__pyx_v_self->pqtable);
  __pyx_v_self->pqtable = ((PyObject*)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":719
 * 
 *         self.pqtable = {}
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)             # <<<<<<<<<<<<<<
 *         for i in range(len(unique_values)):
 *             v = unique_values[i]
 */
  __Pyx_TraceLine(719,0,__PYX_ERR(0, 719, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyDict_Keys(__pyx_v_pvalue_stat); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 719, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_2 = PySequence_List(__pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 719, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 719, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_2);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 719, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_reverse, Py_True) < 0) __PYX_ERR(0, 719, __pyx_L1_error)
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_sorted, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 719, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (!(likely(PyList_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 719, __pyx_L1_error)
  __pyx_v_unique_values = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":720
 *         self.pqtable = {}
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)
 *         for i in range(len(unique_values)):             # <<<<<<<<<<<<<<
 *             v = unique_values[i]
 *             l = pvalue_stat[v]
 */
  __Pyx_TraceLine(720,0,__PYX_ERR(0, 720, __pyx_L1_error))
  if (unlikely(__pyx_v_unique_values == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 720, __pyx_L1_error)
  }
  __pyx_t_4 = PyList_GET_SIZE(__pyx_v_unique_values); if (unlikely(__pyx_t_4 == ((Py_ssize_t)-1))) __PYX_ERR(0, 720, __pyx_L1_error)
  __pyx_t_5 = __pyx_t_4;
  for (__pyx_t_6 = 0; __pyx_t_6 < __pyx_t_5; __pyx_t_6+=1) {
    __pyx_v_i = __pyx_t_6;

    /* "MACS2/IO/CallPeakUnit.pyx":721
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)
 *         for i in range(len(unique_values)):
 *             v = unique_values[i]             # <<<<<<<<<<<<<<
 *             l = pvalue_stat[v]
 *             q = v + (log10(k) + f)
 */
    __Pyx_TraceLine(721,0,__PYX_ERR(0, 721, __pyx_L1_error))
    if (unlikely(__pyx_v_unique_values == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 721, __pyx_L1_error)
    }
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_unique_values, __pyx_v_i, __pyx_t_5numpy_int64_t, 1, __Pyx_PyInt_From_npy_int64, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 721, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_13 = __pyx_PyFloat_AsFloat(__pyx_t_1); if (unlikely((__pyx_t_13 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 721, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_v = __pyx_t_13;

    /* "MACS2/IO/CallPeakUnit.pyx":722
 *         for i in range(len(unique_values)):
 *             v = unique_values[i]
 *             l = pvalue_stat[v]             # <<<<<<<<<<<<<<
 *             q = v + (log10(k) + f)
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 */
    __Pyx_TraceLine(722,0,__PYX_ERR(0, 722, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_v); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 722, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_2 = __Pyx_PyDict_GetItem(__pyx_v_pvalue_stat, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 722, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_10 = __Pyx_PyInt_As_npy_int64(__pyx_t_2); if (unlikely((__pyx_t_10 == ((npy_int64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 722, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_v_l = __pyx_t_10;

    /* "MACS2/IO/CallPeakUnit.pyx":723
 *             v = unique_values[i]
 *             l = pvalue_stat[v]
 *             q = v + (log10(k) + f)             # <<<<<<<<<<<<<<
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 *             self.pqtable[ v ] = q
 */
    __Pyx_TraceLine(723,0,__PYX_ERR(0, 723, __pyx_L1_error))
    __pyx_v_q = (__pyx_v_v + (log10(__pyx_v_k) + __pyx_v_f));

    /* "MACS2/IO/CallPeakUnit.pyx":724
 *             l = pvalue_stat[v]
 *             q = v + (log10(k) + f)
 *             q = max(0,min(pre_q,q))           # make q-score monotonic             # <<<<<<<<<<<<<<
 *             self.pqtable[ v ] = q
 *             pre_v = v
 */
    __Pyx_TraceLine(724,0,__PYX_ERR(0, 724, __pyx_L1_error))
    __pyx_t_13 = __pyx_v_q;
    __pyx_t_14 = __pyx_v_pre_q;
    if (((__pyx_t_13 < __pyx_t_14) != 0)) {
      __pyx_t_15 = __pyx_t_13;
    } else {
      __pyx_t_15 = __pyx_t_14;
    }
    __pyx_t_13 = __pyx_t_15;
    __pyx_t_16 = 0;
    if (((__pyx_t_13 > __pyx_t_16) != 0)) {
      __pyx_t_15 = __pyx_t_13;
    } else {
      __pyx_t_15 = __pyx_t_16;
    }
    __pyx_v_q = __pyx_t_15;

    /* "MACS2/IO/CallPeakUnit.pyx":725
 *             q = v + (log10(k) + f)
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 *             self.pqtable[ v ] = q             # <<<<<<<<<<<<<<
 *             pre_v = v
 *             pre_q = q
 */
    __Pyx_TraceLine(725,0,__PYX_ERR(0, 725, __pyx_L1_error))
    __pyx_t_2 = PyFloat_FromDouble(__pyx_v_q); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 725, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    if (unlikely(__pyx_v_self->pqtable == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 725, __pyx_L1_error)
    }
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_v); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 725, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (unlikely(PyDict_SetItem(__pyx_v_self->pqtable, __pyx_t_1, __pyx_t_2) < 0)) __PYX_ERR(0, 725, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":726
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 *             self.pqtable[ v ] = q
 *             pre_v = v             # <<<<<<<<<<<<<<
 *             pre_q = q
 *             k += l
 */
    __Pyx_TraceLine(726,0,__PYX_ERR(0, 726, __pyx_L1_error))
    __pyx_v_pre_v = __pyx_v_v;

    /* "MACS2/IO/CallPeakUnit.pyx":727
 *             self.pqtable[ v ] = q
 *             pre_v = v
 *             pre_q = q             # <<<<<<<<<<<<<<
 *             k += l
 *             nhcal += 1
 */
    __Pyx_TraceLine(727,0,__PYX_ERR(0, 727, __pyx_L1_error))
    __pyx_v_pre_q = __pyx_v_q;

    /* "MACS2/IO/CallPeakUnit.pyx":728
 *             pre_v = v
 *             pre_q = q
 *             k += l             # <<<<<<<<<<<<<<
 *             nhcal += 1
 * 
 */
    __Pyx_TraceLine(728,0,__PYX_ERR(0, 728, __pyx_L1_error))
    __pyx_v_k = (__pyx_v_k + __pyx_v_l);

    /* "MACS2/IO/CallPeakUnit.pyx":729
 *             pre_q = q
 *             k += l
 *             nhcal += 1             # <<<<<<<<<<<<<<
 * 
 *         logging.debug( "access pq hash for %d times" % nhcal )
 */
    __Pyx_TraceLine(729,0,__PYX_ERR(0, 729, __pyx_L1_error))
    __pyx_v_nhcal = (__pyx_v_nhcal + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":731
 *             nhcal += 1
 * 
 *         logging.debug( "access pq hash for %d times" % nhcal )             # <<<<<<<<<<<<<<
 * 
 *         return
 */
  __Pyx_TraceLine(731,0,__PYX_ERR(0, 731, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_logging); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 731, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_debug); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 731, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_npy_int64(__pyx_v_nhcal); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 731, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_7 = PyUnicode_Format(__pyx_kp_u_access_pq_hash_for_d_times, __pyx_t_1); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 731, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_1 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_1)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_1);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
    }
  }
  __pyx_t_2 = (__pyx_t_1) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_1, __pyx_t_7) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_t_7);
  __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 731, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":733
 *         logging.debug( "access pq hash for %d times" % nhcal )
 * 
 *         return             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_TraceLine(733,0,__PYX_ERR(0, 733, __pyx_L1_error))
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":655
 *         return s
 * 
 *     cdef void __cal_pvalue_qvalue_table ( self ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.pqtable is built. All
 *         chromosomes will be iterated. So it will take some time.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_pvalue_qvalue_table", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_chrom);
  __Pyx_XDECREF((PyObject *)__pyx_v_pos_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_treat_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_ctrl_array);
  __Pyx_XDECREF(__pyx_v_pvalue_stat);
  __Pyx_XDECREF(__pyx_v_unique_values);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "MACS2/IO/CallPeakUnit.pyx":736
 * 
 * 
 *     cdef void __pre_computes ( self, int32_t max_gap = 50, int32_t min_length = 200 ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.pqtable and self.pvalue_length is built. All
 *         chromosomes will be iterated. So it will take some time.
 */

static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes *__pyx_optional_args) {
  __pyx_t_5numpy_int32_t __pyx_v_max_gap = ((__pyx_t_5numpy_int32_t)50);
  __pyx_t_5numpy_int32_t __pyx_v_min_length = ((__pyx_t_5numpy_int32_t)0xC8);
  PyObject *__pyx_v_chrom = 0;
  PyArrayObject *__pyx_v_pos_array = 0;
  PyArrayObject *__pyx_v_treat_array = 0;
  PyArrayObject *__pyx_v_ctrl_array = 0;
  PyArrayObject *__pyx_v_score_array = 0;
  PyObject *__pyx_v_pvalue_stat = 0;
  __pyx_t_5numpy_int64_t __pyx_v_n;
  __pyx_t_5numpy_int64_t __pyx_v_pre_p;
  __pyx_t_5numpy_int64_t __pyx_v_this_p;
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_pre_l;
  __pyx_t_5numpy_int64_t __pyx_v_l;
  __pyx_t_5numpy_int64_t __pyx_v_i;
  __pyx_t_5numpy_float32_t __pyx_v_q;
  __pyx_t_5numpy_float32_t __pyx_v_pre_q;
  __pyx_t_5numpy_float32_t __pyx_v_this_v;
  CYTHON_UNUSED __pyx_t_5numpy_float32_t __pyx_v_pre_v;
  __pyx_t_5numpy_float32_t __pyx_v_v;
  __pyx_t_5numpy_float32_t __pyx_v_cutoff;
  __pyx_t_5numpy_int64_t __pyx_v_N;
  __pyx_t_5numpy_int64_t __pyx_v_k;
  __pyx_t_5numpy_int64_t __pyx_v_this_l;
  __pyx_t_5numpy_float32_t __pyx_v_f;
  __pyx_t_5numpy_int64_t __pyx_v_nhcal;
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_npcal;
  PyObject *__pyx_v_unique_values = 0;
  PyArrayObject *__pyx_v_above_cutoff = 0;
  PyArrayObject *__pyx_v_above_cutoff_endpos = 0;
  PyArrayObject *__pyx_v_above_cutoff_startpos = 0;
  PyObject *__pyx_v_peak_content = 0;
  __pyx_t_5numpy_int64_t __pyx_v_peak_length;
  __pyx_t_5numpy_int64_t __pyx_v_total_l;
  __pyx_t_5numpy_int64_t __pyx_v_total_p;
  PyObject *__pyx_v_tmplist = 0;
  __pyx_t_5numpy_int32_t *__pyx_v_acs_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_ace_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_pos_array_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_score_array_ptr;
  PyObject *__pyx_v_lastp = NULL;
  PyObject *__pyx_v_tl = NULL;
  CYTHON_UNUSED long __pyx_v_nhval;
  PyObject *__pyx_v_fhd = NULL;
  PyObject *__pyx_v_x = NULL;
  PyObject *__pyx_v_y = NULL;
  PyObject *__pyx_8genexpr3__pyx_v_x = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  Py_ssize_t __pyx_t_5;
  PyObject *(*__pyx_t_6)(PyObject *);
  Py_ssize_t __pyx_t_7;
  __pyx_t_5numpy_int64_t __pyx_t_8;
  Py_ssize_t __pyx_t_9;
  Py_ssize_t __pyx_t_10;
  __pyx_t_5numpy_int64_t __pyx_t_11;
  __pyx_t_5numpy_float32_t __pyx_t_12;
  int __pyx_t_13;
  long __pyx_t_14;
  long __pyx_t_15;
  __pyx_t_5numpy_int64_t __pyx_t_16;
  int __pyx_t_17;
  __pyx_t_5numpy_int64_t __pyx_t_18;
  npy_intp __pyx_t_19;
  npy_intp __pyx_t_20;
  int __pyx_t_21;
  __pyx_t_5numpy_float32_t __pyx_t_22;
  __pyx_t_5numpy_float32_t __pyx_t_23;
  Py_UCS4 __pyx_t_24;
  PyObject *__pyx_t_25 = NULL;
  PyObject *__pyx_t_26 = NULL;
  PyObject *__pyx_t_27 = NULL;
  __Pyx_RefNannySetupContext("__pre_computes", 0);
  __Pyx_TraceCall("__pre_computes", __pyx_f[0], 736, 0, __PYX_ERR(0, 736, __pyx_L1_error));
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_max_gap = __pyx_optional_args->max_gap;
      if (__pyx_optional_args->__pyx_n > 1) {
        __pyx_v_min_length = __pyx_optional_args->min_length;
      }
    }
  }

  /* "MACS2/IO/CallPeakUnit.pyx":750
 *             int64_t N, k, this_l
 *             float32_t f
 *             int64_t nhcal = 0             # <<<<<<<<<<<<<<
 *             int64_t npcal = 0
 *             list unique_values
 */
  __Pyx_TraceLine(750,0,__PYX_ERR(0, 750, __pyx_L1_error))
  __pyx_v_nhcal = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":751
 *             float32_t f
 *             int64_t nhcal = 0
 *             int64_t npcal = 0             # <<<<<<<<<<<<<<
 *             list unique_values
 *             float64_t t0, t1, t
 */
  __Pyx_TraceLine(751,0,__PYX_ERR(0, 751, __pyx_L1_error))
  __pyx_v_npcal = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":766
 *             float32_t * score_array_ptr # score array pointer
 * 
 *         logging.debug ( "Start to calculate pvalue stat..." )             # <<<<<<<<<<<<<<
 * 
 *         # tmplist contains a list of log pvalue cutoffs from 0.3 to 10
 */
  __Pyx_TraceLine(766,0,__PYX_ERR(0, 766, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 766, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_debug); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 766, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
    }
  }
  __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_2, __pyx_kp_u_Start_to_calculate_pvalue_stat) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_kp_u_Start_to_calculate_pvalue_stat);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 766, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":769
 * 
 *         # tmplist contains a list of log pvalue cutoffs from 0.3 to 10
 *         tmplist = [round(x,5) for x in sorted( list(np.arange(0.3, 10.0, 0.3)), reverse = True )]             # <<<<<<<<<<<<<<
 * 
 *         pvalue_stat = dict()
 */
  __Pyx_TraceLine(769,0,__PYX_ERR(0, 769, __pyx_L1_error))
  { /* enter inner scope */
    __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_np); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_arange); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_tuple__8, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = PySequence_List(__pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_2);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_2);
    __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_2);
    if (PyDict_SetItem(__pyx_t_2, __pyx_n_s_reverse, Py_True) < 0) __PYX_ERR(0, 769, __pyx_L5_error)
    __pyx_t_4 = __Pyx_PyObject_Call(__pyx_builtin_sorted, __pyx_t_3, __pyx_t_2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 769, __pyx_L5_error)
    __Pyx_GOTREF(__pyx_t_4);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (likely(PyList_CheckExact(__pyx_t_4)) || PyTuple_CheckExact(__pyx_t_4)) {
      __pyx_t_2 = __pyx_t_4; __Pyx_INCREF(__pyx_t_2); __pyx_t_5 = 0;
      __pyx_t_6 = NULL;
    } else {
      __pyx_t_5 = -1; __pyx_t_2 = PyObject_GetIter(__pyx_t_4); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 769, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_6 = Py_TYPE(__pyx_t_2)->tp_iternext; if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 769, __pyx_L5_error)
    }
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    for (;;) {
      if (likely(!__pyx_t_6)) {
        if (likely(PyList_CheckExact(__pyx_t_2))) {
          if (__pyx_t_5 >= PyList_GET_SIZE(__pyx_t_2)) break;
          #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
          __pyx_t_4 = PyList_GET_ITEM(__pyx_t_2, __pyx_t_5); __Pyx_INCREF(__pyx_t_4); __pyx_t_5++; if (unlikely(0 < 0)) __PYX_ERR(0, 769, __pyx_L5_error)
          #else
          __pyx_t_4 = PySequence_ITEM(__pyx_t_2, __pyx_t_5); __pyx_t_5++; if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 769, __pyx_L5_error)
          __Pyx_GOTREF(__pyx_t_4);
          #endif
        } else {
          if (__pyx_t_5 >= PyTuple_GET_SIZE(__pyx_t_2)) break;
          #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
          __pyx_t_4 = PyTuple_GET_ITEM(__pyx_t_2, __pyx_t_5); __Pyx_INCREF(__pyx_t_4); __pyx_t_5++; if (unlikely(0 < 0)) __PYX_ERR(0, 769, __pyx_L5_error)
          #else
          __pyx_t_4 = PySequence_ITEM(__pyx_t_2, __pyx_t_5); __pyx_t_5++; if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 769, __pyx_L5_error)
          __Pyx_GOTREF(__pyx_t_4);
          #endif
        }
      } else {
        __pyx_t_4 = __pyx_t_6(__pyx_t_2);
        if (unlikely(!__pyx_t_4)) {
          PyObject* exc_type = PyErr_Occurred();
          if (exc_type) {
            if (likely(__Pyx_PyErr_GivenExceptionMatches(exc_type, PyExc_StopIteration))) PyErr_Clear();
            else __PYX_ERR(0, 769, __pyx_L5_error)
          }
          break;
        }
        __Pyx_GOTREF(__pyx_t_4);
      }
      __Pyx_XDECREF_SET(__pyx_8genexpr3__pyx_v_x, __pyx_t_4);
      __pyx_t_4 = 0;
      __pyx_t_4 = PyTuple_New(2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 769, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_INCREF(__pyx_8genexpr3__pyx_v_x);
      __Pyx_GIVEREF(__pyx_8genexpr3__pyx_v_x);
      PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_8genexpr3__pyx_v_x);
      __Pyx_INCREF(__pyx_int_5);
      __Pyx_GIVEREF(__pyx_int_5);
      PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_int_5);
      __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_round, __pyx_t_4, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 769, __pyx_L5_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (unlikely(__Pyx_ListComp_Append(__pyx_t_1, (PyObject*)__pyx_t_3))) __PYX_ERR(0, 769, __pyx_L5_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    }
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_8genexpr3__pyx_v_x); __pyx_8genexpr3__pyx_v_x = 0;
    goto __pyx_L8_exit_scope;
    __pyx_L5_error:;
    __Pyx_XDECREF(__pyx_8genexpr3__pyx_v_x); __pyx_8genexpr3__pyx_v_x = 0;
    goto __pyx_L1_error;
    __pyx_L8_exit_scope:;
  } /* exit inner scope */
  __pyx_v_tmplist = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":771
 *         tmplist = [round(x,5) for x in sorted( list(np.arange(0.3, 10.0, 0.3)), reverse = True )]
 * 
 *         pvalue_stat = dict()             # <<<<<<<<<<<<<<
 *         #print (list(pvalue_stat.keys()))
 *         #print (list(self.pvalue_length.keys()))
 */
  __Pyx_TraceLine(771,0,__PYX_ERR(0, 771, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 771, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_pvalue_stat = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":775
 *         #print (list(self.pvalue_length.keys()))
 *         #print (list(self.pvalue_npeaks.keys()))
 *         for i in range( len( self.chromosomes ) ):             # <<<<<<<<<<<<<<
 *             chrom = self.chromosomes[ i ]
 *             self.__pileup_treat_ctrl_a_chromosome( chrom )
 */
  __Pyx_TraceLine(775,0,__PYX_ERR(0, 775, __pyx_L1_error))
  __pyx_t_1 = __pyx_v_self->chromosomes;
  __Pyx_INCREF(__pyx_t_1);
  if (unlikely(__pyx_t_1 == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 775, __pyx_L1_error)
  }
  __pyx_t_5 = PyList_GET_SIZE(__pyx_t_1); if (unlikely(__pyx_t_5 == ((Py_ssize_t)-1))) __PYX_ERR(0, 775, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_7 = __pyx_t_5;
  for (__pyx_t_8 = 0; __pyx_t_8 < __pyx_t_7; __pyx_t_8+=1) {
    __pyx_v_i = __pyx_t_8;

    /* "MACS2/IO/CallPeakUnit.pyx":776
 *         #print (list(self.pvalue_npeaks.keys()))
 *         for i in range( len( self.chromosomes ) ):
 *             chrom = self.chromosomes[ i ]             # <<<<<<<<<<<<<<
 *             self.__pileup_treat_ctrl_a_chromosome( chrom )
 *             [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 */
    __Pyx_TraceLine(776,0,__PYX_ERR(0, 776, __pyx_L1_error))
    if (unlikely(__pyx_v_self->chromosomes == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 776, __pyx_L1_error)
    }
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_self->chromosomes, __pyx_v_i, __pyx_t_5numpy_int64_t, 1, __Pyx_PyInt_From_npy_int64, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 776, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (!(likely(PyBytes_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 776, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_chrom, ((PyObject*)__pyx_t_1));
    __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":777
 *         for i in range( len( self.chromosomes ) ):
 *             chrom = self.chromosomes[ i ]
 *             self.__pileup_treat_ctrl_a_chromosome( chrom )             # <<<<<<<<<<<<<<
 *             [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 * 
 */
    __Pyx_TraceLine(777,0,__PYX_ERR(0, 777, __pyx_L1_error))
    __pyx_t_1 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___pileup_treat_ctrl_a_chromosome(__pyx_v_self, __pyx_v_chrom); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 777, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":778
 *             chrom = self.chromosomes[ i ]
 *             self.__pileup_treat_ctrl_a_chromosome( chrom )
 *             [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl             # <<<<<<<<<<<<<<
 * 
 *             score_array = self.__cal_pscore( treat_array, ctrl_array )
 */
    __Pyx_TraceLine(778,0,__PYX_ERR(0, 778, __pyx_L1_error))
    __pyx_t_1 = __pyx_v_self->chr_pos_treat_ctrl;
    __Pyx_INCREF(__pyx_t_1);
    if (likely(__pyx_t_1 != Py_None)) {
      PyObject* sequence = __pyx_t_1;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 3)) {
        if (size > 3) __Pyx_RaiseTooManyValuesError(3);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 778, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      __pyx_t_2 = PyList_GET_ITEM(sequence, 0); 
      __pyx_t_3 = PyList_GET_ITEM(sequence, 1); 
      __pyx_t_4 = PyList_GET_ITEM(sequence, 2); 
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      #else
      __pyx_t_2 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 778, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_3 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 778, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PySequence_ITEM(sequence, 2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 778, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    } else {
      __Pyx_RaiseNoneNotIterableError(); __PYX_ERR(0, 778, __pyx_L1_error)
    }
    if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 778, __pyx_L1_error)
    if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 778, __pyx_L1_error)
    if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 778, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_pos_array, ((PyArrayObject *)__pyx_t_2));
    __pyx_t_2 = 0;
    __Pyx_XDECREF_SET(__pyx_v_treat_array, ((PyArrayObject *)__pyx_t_3));
    __pyx_t_3 = 0;
    __Pyx_XDECREF_SET(__pyx_v_ctrl_array, ((PyArrayObject *)__pyx_t_4));
    __pyx_t_4 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":780
 *             [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 * 
 *             score_array = self.__cal_pscore( treat_array, ctrl_array )             # <<<<<<<<<<<<<<
 * 
 *             for n in range( len( tmplist ) ):
 */
    __Pyx_TraceLine(780,0,__PYX_ERR(0, 780, __pyx_L1_error))
    __pyx_t_1 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_pscore(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 780, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_XDECREF_SET(__pyx_v_score_array, ((PyArrayObject *)__pyx_t_1));
    __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":782
 *             score_array = self.__cal_pscore( treat_array, ctrl_array )
 * 
 *             for n in range( len( tmplist ) ):             # <<<<<<<<<<<<<<
 *                 cutoff = tmplist[ n ]
 *                 total_l = 0           # total length in potential peak
 */
    __Pyx_TraceLine(782,0,__PYX_ERR(0, 782, __pyx_L1_error))
    __pyx_t_9 = PyList_GET_SIZE(__pyx_v_tmplist); if (unlikely(__pyx_t_9 == ((Py_ssize_t)-1))) __PYX_ERR(0, 782, __pyx_L1_error)
    __pyx_t_10 = __pyx_t_9;
    for (__pyx_t_11 = 0; __pyx_t_11 < __pyx_t_10; __pyx_t_11+=1) {
      __pyx_v_n = __pyx_t_11;

      /* "MACS2/IO/CallPeakUnit.pyx":783
 * 
 *             for n in range( len( tmplist ) ):
 *                 cutoff = tmplist[ n ]             # <<<<<<<<<<<<<<
 *                 total_l = 0           # total length in potential peak
 *                 total_p = 0
 */
      __Pyx_TraceLine(783,0,__PYX_ERR(0, 783, __pyx_L1_error))
      __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_tmplist, __pyx_v_n, __pyx_t_5numpy_int64_t, 1, __Pyx_PyInt_From_npy_int64, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 783, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_12 = __pyx_PyFloat_AsFloat(__pyx_t_1); if (unlikely((__pyx_t_12 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 783, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_v_cutoff = __pyx_t_12;

      /* "MACS2/IO/CallPeakUnit.pyx":784
 *             for n in range( len( tmplist ) ):
 *                 cutoff = tmplist[ n ]
 *                 total_l = 0           # total length in potential peak             # <<<<<<<<<<<<<<
 *                 total_p = 0
 * 
 */
      __Pyx_TraceLine(784,0,__PYX_ERR(0, 784, __pyx_L1_error))
      __pyx_v_total_l = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":785
 *                 cutoff = tmplist[ n ]
 *                 total_l = 0           # total length in potential peak
 *                 total_p = 0             # <<<<<<<<<<<<<<
 * 
 *                 # get the regions with scores above cutoffs
 */
      __Pyx_TraceLine(785,0,__PYX_ERR(0, 785, __pyx_L1_error))
      __pyx_v_total_p = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":788
 * 
 *                 # get the regions with scores above cutoffs
 *                 above_cutoff = np.nonzero( score_array > cutoff )[0]# this is not an optimized method. It would be better to store score array in a 2-D ndarray?             # <<<<<<<<<<<<<<
 *                 above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *                 above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 */
      __Pyx_TraceLine(788,0,__PYX_ERR(0, 788, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_np); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 788, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_nonzero); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 788, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_4 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 788, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_2 = PyObject_RichCompare(((PyObject *)__pyx_v_score_array), __pyx_t_4, Py_GT); __Pyx_XGOTREF(__pyx_t_2); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 788, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_4 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
        __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_3);
        if (likely(__pyx_t_4)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
          __Pyx_INCREF(__pyx_t_4);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_3, function);
        }
      }
      __pyx_t_1 = (__pyx_t_4) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_4, __pyx_t_2) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_t_2);
      __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 788, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_3 = __Pyx_GetItemInt(__pyx_t_1, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 788, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 788, __pyx_L1_error)
      __Pyx_XDECREF_SET(__pyx_v_above_cutoff, ((PyArrayObject *)__pyx_t_3));
      __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":789
 *                 # get the regions with scores above cutoffs
 *                 above_cutoff = np.nonzero( score_array > cutoff )[0]# this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *                 above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 *                 above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 */
      __Pyx_TraceLine(789,0,__PYX_ERR(0, 789, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), ((PyObject *)__pyx_v_above_cutoff)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 789, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 789, __pyx_L1_error)
      __Pyx_XDECREF_SET(__pyx_v_above_cutoff_endpos, ((PyArrayObject *)__pyx_t_3));
      __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":790
 *                 above_cutoff = np.nonzero( score_array > cutoff )[0]# this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *                 above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *                 above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 * 
 *                 if above_cutoff_endpos.size == 0:
 */
      __Pyx_TraceLine(790,0,__PYX_ERR(0, 790, __pyx_L1_error))
      __pyx_t_3 = PyNumber_Subtract(((PyObject *)__pyx_v_above_cutoff), __pyx_int_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 790, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_1 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 790, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 790, __pyx_L1_error)
      __Pyx_XDECREF_SET(__pyx_v_above_cutoff_startpos, ((PyArrayObject *)__pyx_t_1));
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":792
 *                 above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *                 if above_cutoff_endpos.size == 0:             # <<<<<<<<<<<<<<
 *                     continue
 * 
 */
      __Pyx_TraceLine(792,0,__PYX_ERR(0, 792, __pyx_L1_error))
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_above_cutoff_endpos), __pyx_n_s_size); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 792, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_3 = __Pyx_PyInt_EqObjC(__pyx_t_1, __pyx_int_0, 0, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 792, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_13 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 792, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_13) {

        /* "MACS2/IO/CallPeakUnit.pyx":793
 * 
 *                 if above_cutoff_endpos.size == 0:
 *                     continue             # <<<<<<<<<<<<<<
 * 
 *                 # first bit of region above cutoff
 */
        __Pyx_TraceLine(793,0,__PYX_ERR(0, 793, __pyx_L1_error))
        goto __pyx_L11_continue;

        /* "MACS2/IO/CallPeakUnit.pyx":792
 *                 above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *                 if above_cutoff_endpos.size == 0:             # <<<<<<<<<<<<<<
 *                     continue
 * 
 */
      }

      /* "MACS2/IO/CallPeakUnit.pyx":796
 * 
 *                 # first bit of region above cutoff
 *                 acs_ptr = <int32_t *> above_cutoff_startpos.data             # <<<<<<<<<<<<<<
 *                 ace_ptr = <int32_t *> above_cutoff_endpos.data
 * 
 */
      __Pyx_TraceLine(796,0,__PYX_ERR(0, 796, __pyx_L1_error))
      __pyx_v_acs_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_startpos->data);

      /* "MACS2/IO/CallPeakUnit.pyx":797
 *                 # first bit of region above cutoff
 *                 acs_ptr = <int32_t *> above_cutoff_startpos.data
 *                 ace_ptr = <int32_t *> above_cutoff_endpos.data             # <<<<<<<<<<<<<<
 * 
 *                 peak_content = [( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]
 */
      __Pyx_TraceLine(797,0,__PYX_ERR(0, 797, __pyx_L1_error))
      __pyx_v_ace_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_endpos->data);

      /* "MACS2/IO/CallPeakUnit.pyx":799
 *                 ace_ptr = <int32_t *> above_cutoff_endpos.data
 * 
 *                 peak_content = [( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]             # <<<<<<<<<<<<<<
 *                 lastp = ace_ptr[ 0 ]
 *                 acs_ptr += 1
 */
      __Pyx_TraceLine(799,0,__PYX_ERR(0, 799, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 799, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_1 = __Pyx_PyInt_From_npy_int32((__pyx_v_ace_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 799, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_2 = PyTuple_New(2); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 799, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_GIVEREF(__pyx_t_3);
      PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_t_3);
      __Pyx_GIVEREF(__pyx_t_1);
      PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_t_1);
      __pyx_t_3 = 0;
      __pyx_t_1 = 0;
      __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 799, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_GIVEREF(__pyx_t_2);
      PyList_SET_ITEM(__pyx_t_1, 0, __pyx_t_2);
      __pyx_t_2 = 0;
      __Pyx_XDECREF_SET(__pyx_v_peak_content, ((PyObject*)__pyx_t_1));
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":800
 * 
 *                 peak_content = [( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]
 *                 lastp = ace_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *                 acs_ptr += 1
 *                 ace_ptr += 1
 */
      __Pyx_TraceLine(800,0,__PYX_ERR(0, 800, __pyx_L1_error))
      __pyx_t_1 = __Pyx_PyInt_From_npy_int32((__pyx_v_ace_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 800, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_XDECREF_SET(__pyx_v_lastp, __pyx_t_1);
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":801
 *                 peak_content = [( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]
 *                 lastp = ace_ptr[ 0 ]
 *                 acs_ptr += 1             # <<<<<<<<<<<<<<
 *                 ace_ptr += 1
 * 
 */
      __Pyx_TraceLine(801,0,__PYX_ERR(0, 801, __pyx_L1_error))
      __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":802
 *                 lastp = ace_ptr[ 0 ]
 *                 acs_ptr += 1
 *                 ace_ptr += 1             # <<<<<<<<<<<<<<
 * 
 *                 for i in range( 1, above_cutoff_startpos.size ):
 */
      __Pyx_TraceLine(802,0,__PYX_ERR(0, 802, __pyx_L1_error))
      __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":804
 *                 ace_ptr += 1
 * 
 *                 for i in range( 1, above_cutoff_startpos.size ):             # <<<<<<<<<<<<<<
 *                     tl = acs_ptr[ 0 ] - lastp
 *                     if tl <= max_gap:
 */
      __Pyx_TraceLine(804,0,__PYX_ERR(0, 804, __pyx_L1_error))
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_above_cutoff_startpos), __pyx_n_s_size); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 804, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_14 = __Pyx_PyInt_As_long(__pyx_t_1); if (unlikely((__pyx_t_14 == (long)-1) && PyErr_Occurred())) __PYX_ERR(0, 804, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_15 = __pyx_t_14;
      for (__pyx_t_16 = 1; __pyx_t_16 < __pyx_t_15; __pyx_t_16+=1) {
        __pyx_v_i = __pyx_t_16;

        /* "MACS2/IO/CallPeakUnit.pyx":805
 * 
 *                 for i in range( 1, above_cutoff_startpos.size ):
 *                     tl = acs_ptr[ 0 ] - lastp             # <<<<<<<<<<<<<<
 *                     if tl <= max_gap:
 *                         peak_content.append( ( acs_ptr[ 0 ], ace_ptr[ 0 ] ) )
 */
        __Pyx_TraceLine(805,0,__PYX_ERR(0, 805, __pyx_L1_error))
        __pyx_t_1 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 805, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_2 = PyNumber_Subtract(__pyx_t_1, __pyx_v_lastp); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 805, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __Pyx_XDECREF_SET(__pyx_v_tl, __pyx_t_2);
        __pyx_t_2 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":806
 *                 for i in range( 1, above_cutoff_startpos.size ):
 *                     tl = acs_ptr[ 0 ] - lastp
 *                     if tl <= max_gap:             # <<<<<<<<<<<<<<
 *                         peak_content.append( ( acs_ptr[ 0 ], ace_ptr[ 0 ] ) )
 *                     else:
 */
        __Pyx_TraceLine(806,0,__PYX_ERR(0, 806, __pyx_L1_error))
        __pyx_t_2 = __Pyx_PyInt_From_npy_int32(__pyx_v_max_gap); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 806, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_1 = PyObject_RichCompare(__pyx_v_tl, __pyx_t_2, Py_LE); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 806, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __pyx_t_13 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 806, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        if (__pyx_t_13) {

          /* "MACS2/IO/CallPeakUnit.pyx":807
 *                     tl = acs_ptr[ 0 ] - lastp
 *                     if tl <= max_gap:
 *                         peak_content.append( ( acs_ptr[ 0 ], ace_ptr[ 0 ] ) )             # <<<<<<<<<<<<<<
 *                     else:
 *                         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 */
          __Pyx_TraceLine(807,0,__PYX_ERR(0, 807, __pyx_L1_error))
          __pyx_t_1 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 807, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __pyx_t_2 = __Pyx_PyInt_From_npy_int32((__pyx_v_ace_ptr[0])); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 807, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_2);
          __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 807, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_3);
          __Pyx_GIVEREF(__pyx_t_1);
          PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
          __Pyx_GIVEREF(__pyx_t_2);
          PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_2);
          __pyx_t_1 = 0;
          __pyx_t_2 = 0;
          __pyx_t_17 = __Pyx_PyList_Append(__pyx_v_peak_content, __pyx_t_3); if (unlikely(__pyx_t_17 == ((int)-1))) __PYX_ERR(0, 807, __pyx_L1_error)
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

          /* "MACS2/IO/CallPeakUnit.pyx":806
 *                 for i in range( 1, above_cutoff_startpos.size ):
 *                     tl = acs_ptr[ 0 ] - lastp
 *                     if tl <= max_gap:             # <<<<<<<<<<<<<<
 *                         peak_content.append( ( acs_ptr[ 0 ], ace_ptr[ 0 ] ) )
 *                     else:
 */
          goto __pyx_L16;
        }

        /* "MACS2/IO/CallPeakUnit.pyx":809
 *                         peak_content.append( ( acs_ptr[ 0 ], ace_ptr[ 0 ] ) )
 *                     else:
 *                         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]             # <<<<<<<<<<<<<<
 *                         if peak_length >= min_length: # if the peak is too small, reject it
 *                             total_l +=  peak_length
 */
        __Pyx_TraceLine(809,0,__PYX_ERR(0, 809, __pyx_L1_error))
        /*else*/ {
          __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 809, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_3);
          __pyx_t_2 = __Pyx_GetItemInt(__pyx_t_3, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 809, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 809, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_3);
          __pyx_t_1 = __Pyx_GetItemInt(__pyx_t_3, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 809, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __pyx_t_3 = PyNumber_Subtract(__pyx_t_2, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 809, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_3);
          __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
          __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
          __pyx_t_18 = __Pyx_PyInt_As_npy_int64(__pyx_t_3); if (unlikely((__pyx_t_18 == ((npy_int64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 809, __pyx_L1_error)
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __pyx_v_peak_length = __pyx_t_18;

          /* "MACS2/IO/CallPeakUnit.pyx":810
 *                     else:
 *                         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                         if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *                             total_l +=  peak_length
 *                             total_p += 1
 */
          __Pyx_TraceLine(810,0,__PYX_ERR(0, 810, __pyx_L1_error))
          __pyx_t_13 = ((__pyx_v_peak_length >= __pyx_v_min_length) != 0);
          if (__pyx_t_13) {

            /* "MACS2/IO/CallPeakUnit.pyx":811
 *                         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                         if peak_length >= min_length: # if the peak is too small, reject it
 *                             total_l +=  peak_length             # <<<<<<<<<<<<<<
 *                             total_p += 1
 *                         peak_content = [ ( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]
 */
            __Pyx_TraceLine(811,0,__PYX_ERR(0, 811, __pyx_L1_error))
            __pyx_v_total_l = (__pyx_v_total_l + __pyx_v_peak_length);

            /* "MACS2/IO/CallPeakUnit.pyx":812
 *                         if peak_length >= min_length: # if the peak is too small, reject it
 *                             total_l +=  peak_length
 *                             total_p += 1             # <<<<<<<<<<<<<<
 *                         peak_content = [ ( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]
 *                     lastp = ace_ptr[ 0 ]
 */
            __Pyx_TraceLine(812,0,__PYX_ERR(0, 812, __pyx_L1_error))
            __pyx_v_total_p = (__pyx_v_total_p + 1);

            /* "MACS2/IO/CallPeakUnit.pyx":810
 *                     else:
 *                         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                         if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *                             total_l +=  peak_length
 *                             total_p += 1
 */
          }

          /* "MACS2/IO/CallPeakUnit.pyx":813
 *                             total_l +=  peak_length
 *                             total_p += 1
 *                         peak_content = [ ( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]             # <<<<<<<<<<<<<<
 *                     lastp = ace_ptr[ 0 ]
 *                     acs_ptr += 1
 */
          __Pyx_TraceLine(813,0,__PYX_ERR(0, 813, __pyx_L1_error))
          __pyx_t_3 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 813, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_3);
          __pyx_t_1 = __Pyx_PyInt_From_npy_int32((__pyx_v_ace_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 813, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __pyx_t_2 = PyTuple_New(2); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 813, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_GIVEREF(__pyx_t_3);
          PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_t_3);
          __Pyx_GIVEREF(__pyx_t_1);
          PyTuple_SET_ITEM(__pyx_t_2, 1, __pyx_t_1);
          __pyx_t_3 = 0;
          __pyx_t_1 = 0;
          __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 813, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __Pyx_GIVEREF(__pyx_t_2);
          PyList_SET_ITEM(__pyx_t_1, 0, __pyx_t_2);
          __pyx_t_2 = 0;
          __Pyx_DECREF_SET(__pyx_v_peak_content, ((PyObject*)__pyx_t_1));
          __pyx_t_1 = 0;
        }
        __pyx_L16:;

        /* "MACS2/IO/CallPeakUnit.pyx":814
 *                             total_p += 1
 *                         peak_content = [ ( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]
 *                     lastp = ace_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *                     acs_ptr += 1
 *                     ace_ptr += 1
 */
        __Pyx_TraceLine(814,0,__PYX_ERR(0, 814, __pyx_L1_error))
        __pyx_t_1 = __Pyx_PyInt_From_npy_int32((__pyx_v_ace_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 814, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_DECREF_SET(__pyx_v_lastp, __pyx_t_1);
        __pyx_t_1 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":815
 *                         peak_content = [ ( acs_ptr[ 0 ], ace_ptr[ 0 ] ), ]
 *                     lastp = ace_ptr[ 0 ]
 *                     acs_ptr += 1             # <<<<<<<<<<<<<<
 *                     ace_ptr += 1
 * 
 */
        __Pyx_TraceLine(815,0,__PYX_ERR(0, 815, __pyx_L1_error))
        __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

        /* "MACS2/IO/CallPeakUnit.pyx":816
 *                     lastp = ace_ptr[ 0 ]
 *                     acs_ptr += 1
 *                     ace_ptr += 1             # <<<<<<<<<<<<<<
 * 
 *                 if peak_content:
 */
        __Pyx_TraceLine(816,0,__PYX_ERR(0, 816, __pyx_L1_error))
        __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);
      }

      /* "MACS2/IO/CallPeakUnit.pyx":818
 *                     ace_ptr += 1
 * 
 *                 if peak_content:             # <<<<<<<<<<<<<<
 *                     peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                     if peak_length >= min_length: # if the peak is too small, reject it
 */
      __Pyx_TraceLine(818,0,__PYX_ERR(0, 818, __pyx_L1_error))
      __pyx_t_13 = (PyList_GET_SIZE(__pyx_v_peak_content) != 0);
      if (__pyx_t_13) {

        /* "MACS2/IO/CallPeakUnit.pyx":819
 * 
 *                 if peak_content:
 *                     peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]             # <<<<<<<<<<<<<<
 *                     if peak_length >= min_length: # if the peak is too small, reject it
 *                         total_l +=  peak_length
 */
        __Pyx_TraceLine(819,0,__PYX_ERR(0, 819, __pyx_L1_error))
        __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 819, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_2 = __Pyx_GetItemInt(__pyx_t_1, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 819, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 819, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_3 = __Pyx_GetItemInt(__pyx_t_1, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 819, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __pyx_t_1 = PyNumber_Subtract(__pyx_t_2, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 819, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __pyx_t_16 = __Pyx_PyInt_As_npy_int64(__pyx_t_1); if (unlikely((__pyx_t_16 == ((npy_int64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 819, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __pyx_v_peak_length = __pyx_t_16;

        /* "MACS2/IO/CallPeakUnit.pyx":820
 *                 if peak_content:
 *                     peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                     if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *                         total_l +=  peak_length
 *                         total_p += 1
 */
        __Pyx_TraceLine(820,0,__PYX_ERR(0, 820, __pyx_L1_error))
        __pyx_t_13 = ((__pyx_v_peak_length >= __pyx_v_min_length) != 0);
        if (__pyx_t_13) {

          /* "MACS2/IO/CallPeakUnit.pyx":821
 *                     peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                     if peak_length >= min_length: # if the peak is too small, reject it
 *                         total_l +=  peak_length             # <<<<<<<<<<<<<<
 *                         total_p += 1
 *                 self.pvalue_length[ cutoff ] = self.pvalue_length.get( cutoff, 0 ) + total_l
 */
          __Pyx_TraceLine(821,0,__PYX_ERR(0, 821, __pyx_L1_error))
          __pyx_v_total_l = (__pyx_v_total_l + __pyx_v_peak_length);

          /* "MACS2/IO/CallPeakUnit.pyx":822
 *                     if peak_length >= min_length: # if the peak is too small, reject it
 *                         total_l +=  peak_length
 *                         total_p += 1             # <<<<<<<<<<<<<<
 *                 self.pvalue_length[ cutoff ] = self.pvalue_length.get( cutoff, 0 ) + total_l
 *                 self.pvalue_npeaks[ cutoff ] = self.pvalue_npeaks.get( cutoff, 0 ) + total_p
 */
          __Pyx_TraceLine(822,0,__PYX_ERR(0, 822, __pyx_L1_error))
          __pyx_v_total_p = (__pyx_v_total_p + 1);

          /* "MACS2/IO/CallPeakUnit.pyx":820
 *                 if peak_content:
 *                     peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                     if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *                         total_l +=  peak_length
 *                         total_p += 1
 */
        }

        /* "MACS2/IO/CallPeakUnit.pyx":818
 *                     ace_ptr += 1
 * 
 *                 if peak_content:             # <<<<<<<<<<<<<<
 *                     peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *                     if peak_length >= min_length: # if the peak is too small, reject it
 */
      }

      /* "MACS2/IO/CallPeakUnit.pyx":823
 *                         total_l +=  peak_length
 *                         total_p += 1
 *                 self.pvalue_length[ cutoff ] = self.pvalue_length.get( cutoff, 0 ) + total_l             # <<<<<<<<<<<<<<
 *                 self.pvalue_npeaks[ cutoff ] = self.pvalue_npeaks.get( cutoff, 0 ) + total_p
 * 
 */
      __Pyx_TraceLine(823,0,__PYX_ERR(0, 823, __pyx_L1_error))
      if (unlikely(__pyx_v_self->pvalue_length == Py_None)) {
        PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "get");
        __PYX_ERR(0, 823, __pyx_L1_error)
      }
      __pyx_t_1 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 823, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_3 = __Pyx_PyDict_GetItemDefault(__pyx_v_self->pvalue_length, __pyx_t_1, __pyx_int_0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 823, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_1 = __Pyx_PyInt_From_npy_int64(__pyx_v_total_l); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 823, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_2 = PyNumber_Add(__pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 823, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      if (unlikely(__pyx_v_self->pvalue_length == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 823, __pyx_L1_error)
      }
      __pyx_t_1 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 823, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (unlikely(PyDict_SetItem(__pyx_v_self->pvalue_length, __pyx_t_1, __pyx_t_2) < 0)) __PYX_ERR(0, 823, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":824
 *                         total_p += 1
 *                 self.pvalue_length[ cutoff ] = self.pvalue_length.get( cutoff, 0 ) + total_l
 *                 self.pvalue_npeaks[ cutoff ] = self.pvalue_npeaks.get( cutoff, 0 ) + total_p             # <<<<<<<<<<<<<<
 * 
 *             pos_array_ptr = <int32_t *> pos_array.data
 */
      __Pyx_TraceLine(824,0,__PYX_ERR(0, 824, __pyx_L1_error))
      if (unlikely(__pyx_v_self->pvalue_npeaks == Py_None)) {
        PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "get");
        __PYX_ERR(0, 824, __pyx_L1_error)
      }
      __pyx_t_2 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 824, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_1 = __Pyx_PyDict_GetItemDefault(__pyx_v_self->pvalue_npeaks, __pyx_t_2, __pyx_int_0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 824, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_2 = __Pyx_PyInt_From_npy_int64(__pyx_v_total_p); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 824, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_3 = PyNumber_Add(__pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 824, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (unlikely(__pyx_v_self->pvalue_npeaks == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 824, __pyx_L1_error)
      }
      __pyx_t_2 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 824, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      if (unlikely(PyDict_SetItem(__pyx_v_self->pvalue_npeaks, __pyx_t_2, __pyx_t_3) < 0)) __PYX_ERR(0, 824, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_L11_continue:;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":826
 *                 self.pvalue_npeaks[ cutoff ] = self.pvalue_npeaks.get( cutoff, 0 ) + total_p
 * 
 *             pos_array_ptr = <int32_t *> pos_array.data             # <<<<<<<<<<<<<<
 *             score_array_ptr = <float32_t *> score_array.data
 * 
 */
    __Pyx_TraceLine(826,0,__PYX_ERR(0, 826, __pyx_L1_error))
    __pyx_v_pos_array_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_pos_array->data);

    /* "MACS2/IO/CallPeakUnit.pyx":827
 * 
 *             pos_array_ptr = <int32_t *> pos_array.data
 *             score_array_ptr = <float32_t *> score_array.data             # <<<<<<<<<<<<<<
 * 
 *             pre_p = 0
 */
    __Pyx_TraceLine(827,0,__PYX_ERR(0, 827, __pyx_L1_error))
    __pyx_v_score_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_score_array->data);

    /* "MACS2/IO/CallPeakUnit.pyx":829
 *             score_array_ptr = <float32_t *> score_array.data
 * 
 *             pre_p = 0             # <<<<<<<<<<<<<<
 *             for i in range(pos_array.shape[0]):
 *                 this_p = pos_array_ptr[ 0 ]
 */
    __Pyx_TraceLine(829,0,__PYX_ERR(0, 829, __pyx_L1_error))
    __pyx_v_pre_p = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":830
 * 
 *             pre_p = 0
 *             for i in range(pos_array.shape[0]):             # <<<<<<<<<<<<<<
 *                 this_p = pos_array_ptr[ 0 ]
 *                 this_l = this_p - pre_p
 */
    __Pyx_TraceLine(830,0,__PYX_ERR(0, 830, __pyx_L1_error))
    __pyx_t_19 = (__pyx_v_pos_array->dimensions[0]);
    __pyx_t_20 = __pyx_t_19;
    for (__pyx_t_11 = 0; __pyx_t_11 < __pyx_t_20; __pyx_t_11+=1) {
      __pyx_v_i = __pyx_t_11;

      /* "MACS2/IO/CallPeakUnit.pyx":831
 *             pre_p = 0
 *             for i in range(pos_array.shape[0]):
 *                 this_p = pos_array_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *                 this_l = this_p - pre_p
 *                 this_v = score_array_ptr[ 0 ]
 */
      __Pyx_TraceLine(831,0,__PYX_ERR(0, 831, __pyx_L1_error))
      __pyx_v_this_p = (__pyx_v_pos_array_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":832
 *             for i in range(pos_array.shape[0]):
 *                 this_p = pos_array_ptr[ 0 ]
 *                 this_l = this_p - pre_p             # <<<<<<<<<<<<<<
 *                 this_v = score_array_ptr[ 0 ]
 *                 if this_v in pvalue_stat:
 */
      __Pyx_TraceLine(832,0,__PYX_ERR(0, 832, __pyx_L1_error))
      __pyx_v_this_l = (__pyx_v_this_p - __pyx_v_pre_p);

      /* "MACS2/IO/CallPeakUnit.pyx":833
 *                 this_p = pos_array_ptr[ 0 ]
 *                 this_l = this_p - pre_p
 *                 this_v = score_array_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *                 if this_v in pvalue_stat:
 *                     pvalue_stat[ this_v ] += this_l
 */
      __Pyx_TraceLine(833,0,__PYX_ERR(0, 833, __pyx_L1_error))
      __pyx_v_this_v = (__pyx_v_score_array_ptr[0]);

      /* "MACS2/IO/CallPeakUnit.pyx":834
 *                 this_l = this_p - pre_p
 *                 this_v = score_array_ptr[ 0 ]
 *                 if this_v in pvalue_stat:             # <<<<<<<<<<<<<<
 *                     pvalue_stat[ this_v ] += this_l
 *                 else:
 */
      __Pyx_TraceLine(834,0,__PYX_ERR(0, 834, __pyx_L1_error))
      __pyx_t_3 = PyFloat_FromDouble(__pyx_v_this_v); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 834, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_13 = (__Pyx_PyDict_ContainsTF(__pyx_t_3, __pyx_v_pvalue_stat, Py_EQ)); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 834, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_21 = (__pyx_t_13 != 0);
      if (__pyx_t_21) {

        /* "MACS2/IO/CallPeakUnit.pyx":835
 *                 this_v = score_array_ptr[ 0 ]
 *                 if this_v in pvalue_stat:
 *                     pvalue_stat[ this_v ] += this_l             # <<<<<<<<<<<<<<
 *                 else:
 *                     pvalue_stat[ this_v ] = this_l
 */
        __Pyx_TraceLine(835,0,__PYX_ERR(0, 835, __pyx_L1_error))
        __pyx_t_3 = PyFloat_FromDouble(__pyx_v_this_v); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 835, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_2 = __Pyx_PyDict_GetItem(__pyx_v_pvalue_stat, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 835, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_1 = __Pyx_PyInt_From_npy_int64(__pyx_v_this_l); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 835, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_4 = PyNumber_InPlaceAdd(__pyx_t_2, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 835, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        if (unlikely(PyDict_SetItem(__pyx_v_pvalue_stat, __pyx_t_3, __pyx_t_4) < 0)) __PYX_ERR(0, 835, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":834
 *                 this_l = this_p - pre_p
 *                 this_v = score_array_ptr[ 0 ]
 *                 if this_v in pvalue_stat:             # <<<<<<<<<<<<<<
 *                     pvalue_stat[ this_v ] += this_l
 *                 else:
 */
        goto __pyx_L22;
      }

      /* "MACS2/IO/CallPeakUnit.pyx":837
 *                     pvalue_stat[ this_v ] += this_l
 *                 else:
 *                     pvalue_stat[ this_v ] = this_l             # <<<<<<<<<<<<<<
 *                 pre_p = this_p #pos_array[ i ]
 *                 pos_array_ptr += 1
 */
      __Pyx_TraceLine(837,0,__PYX_ERR(0, 837, __pyx_L1_error))
      /*else*/ {
        __pyx_t_3 = __Pyx_PyInt_From_npy_int64(__pyx_v_this_l); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 837, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_4 = PyFloat_FromDouble(__pyx_v_this_v); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 837, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        if (unlikely(PyDict_SetItem(__pyx_v_pvalue_stat, __pyx_t_4, __pyx_t_3) < 0)) __PYX_ERR(0, 837, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      }
      __pyx_L22:;

      /* "MACS2/IO/CallPeakUnit.pyx":838
 *                 else:
 *                     pvalue_stat[ this_v ] = this_l
 *                 pre_p = this_p #pos_array[ i ]             # <<<<<<<<<<<<<<
 *                 pos_array_ptr += 1
 *                 score_array_ptr += 1
 */
      __Pyx_TraceLine(838,0,__PYX_ERR(0, 838, __pyx_L1_error))
      __pyx_v_pre_p = __pyx_v_this_p;

      /* "MACS2/IO/CallPeakUnit.pyx":839
 *                     pvalue_stat[ this_v ] = this_l
 *                 pre_p = this_p #pos_array[ i ]
 *                 pos_array_ptr += 1             # <<<<<<<<<<<<<<
 *                 score_array_ptr += 1
 * 
 */
      __Pyx_TraceLine(839,0,__PYX_ERR(0, 839, __pyx_L1_error))
      __pyx_v_pos_array_ptr = (__pyx_v_pos_array_ptr + 1);

      /* "MACS2/IO/CallPeakUnit.pyx":840
 *                 pre_p = this_p #pos_array[ i ]
 *                 pos_array_ptr += 1
 *                 score_array_ptr += 1             # <<<<<<<<<<<<<<
 * 
 *             nhcal += pos_array.shape[0]
 */
      __Pyx_TraceLine(840,0,__PYX_ERR(0, 840, __pyx_L1_error))
      __pyx_v_score_array_ptr = (__pyx_v_score_array_ptr + 1);
    }

    /* "MACS2/IO/CallPeakUnit.pyx":842
 *                 score_array_ptr += 1
 * 
 *             nhcal += pos_array.shape[0]             # <<<<<<<<<<<<<<
 * 
 *         #logging.debug ( "make pvalue_stat cost %.5f seconds" % t )
 */
    __Pyx_TraceLine(842,0,__PYX_ERR(0, 842, __pyx_L1_error))
    __pyx_v_nhcal = (__pyx_v_nhcal + (__pyx_v_pos_array->dimensions[0]));
  }

  /* "MACS2/IO/CallPeakUnit.pyx":849
 *         # add all pvalue cutoffs from cutoff-analysis part. So that we
 *         # can get the corresponding qvalues for them.
 *         for cutoff in tmplist:             # <<<<<<<<<<<<<<
 *             if cutoff not in pvalue_stat:
 *                 pvalue_stat[ cutoff ] = 0
 */
  __Pyx_TraceLine(849,0,__PYX_ERR(0, 849, __pyx_L1_error))
  __pyx_t_3 = __pyx_v_tmplist; __Pyx_INCREF(__pyx_t_3); __pyx_t_5 = 0;
  for (;;) {
    if (__pyx_t_5 >= PyList_GET_SIZE(__pyx_t_3)) break;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_4 = PyList_GET_ITEM(__pyx_t_3, __pyx_t_5); __Pyx_INCREF(__pyx_t_4); __pyx_t_5++; if (unlikely(0 < 0)) __PYX_ERR(0, 849, __pyx_L1_error)
    #else
    __pyx_t_4 = PySequence_ITEM(__pyx_t_3, __pyx_t_5); __pyx_t_5++; if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 849, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    #endif
    __pyx_t_12 = __pyx_PyFloat_AsFloat(__pyx_t_4); if (unlikely((__pyx_t_12 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 849, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_v_cutoff = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":850
 *         # can get the corresponding qvalues for them.
 *         for cutoff in tmplist:
 *             if cutoff not in pvalue_stat:             # <<<<<<<<<<<<<<
 *                 pvalue_stat[ cutoff ] = 0
 * 
 */
    __Pyx_TraceLine(850,0,__PYX_ERR(0, 850, __pyx_L1_error))
    __pyx_t_4 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 850, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_21 = (__Pyx_PyDict_ContainsTF(__pyx_t_4, __pyx_v_pvalue_stat, Py_NE)); if (unlikely(__pyx_t_21 < 0)) __PYX_ERR(0, 850, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_13 = (__pyx_t_21 != 0);
    if (__pyx_t_13) {

      /* "MACS2/IO/CallPeakUnit.pyx":851
 *         for cutoff in tmplist:
 *             if cutoff not in pvalue_stat:
 *                 pvalue_stat[ cutoff ] = 0             # <<<<<<<<<<<<<<
 * 
 *         nhval = 0
 */
      __Pyx_TraceLine(851,0,__PYX_ERR(0, 851, __pyx_L1_error))
      __pyx_t_4 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 851, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      if (unlikely(PyDict_SetItem(__pyx_v_pvalue_stat, __pyx_t_4, __pyx_int_0) < 0)) __PYX_ERR(0, 851, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":850
 *         # can get the corresponding qvalues for them.
 *         for cutoff in tmplist:
 *             if cutoff not in pvalue_stat:             # <<<<<<<<<<<<<<
 *                 pvalue_stat[ cutoff ] = 0
 * 
 */
    }

    /* "MACS2/IO/CallPeakUnit.pyx":849
 *         # add all pvalue cutoffs from cutoff-analysis part. So that we
 *         # can get the corresponding qvalues for them.
 *         for cutoff in tmplist:             # <<<<<<<<<<<<<<
 *             if cutoff not in pvalue_stat:
 *                 pvalue_stat[ cutoff ] = 0
 */
    __Pyx_TraceLine(849,0,__PYX_ERR(0, 849, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":853
 *                 pvalue_stat[ cutoff ] = 0
 * 
 *         nhval = 0             # <<<<<<<<<<<<<<
 * 
 *         N = sum(pvalue_stat.values()) # total length
 */
  __Pyx_TraceLine(853,0,__PYX_ERR(0, 853, __pyx_L1_error))
  __pyx_v_nhval = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":855
 *         nhval = 0
 * 
 *         N = sum(pvalue_stat.values()) # total length             # <<<<<<<<<<<<<<
 *         k = 1                           # rank
 *         f = -log10(N)
 */
  __Pyx_TraceLine(855,0,__PYX_ERR(0, 855, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyDict_Values(__pyx_v_pvalue_stat); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 855, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = __Pyx_PyObject_CallOneArg(__pyx_builtin_sum, __pyx_t_3); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 855, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_8 = __Pyx_PyInt_As_npy_int64(__pyx_t_4); if (unlikely((__pyx_t_8 == ((npy_int64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 855, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_v_N = __pyx_t_8;

  /* "MACS2/IO/CallPeakUnit.pyx":856
 * 
 *         N = sum(pvalue_stat.values()) # total length
 *         k = 1                           # rank             # <<<<<<<<<<<<<<
 *         f = -log10(N)
 *         pre_v = -2147483647
 */
  __Pyx_TraceLine(856,0,__PYX_ERR(0, 856, __pyx_L1_error))
  __pyx_v_k = 1;

  /* "MACS2/IO/CallPeakUnit.pyx":857
 *         N = sum(pvalue_stat.values()) # total length
 *         k = 1                           # rank
 *         f = -log10(N)             # <<<<<<<<<<<<<<
 *         pre_v = -2147483647
 *         pre_l = 0
 */
  __Pyx_TraceLine(857,0,__PYX_ERR(0, 857, __pyx_L1_error))
  __pyx_v_f = (-log10(__pyx_v_N));

  /* "MACS2/IO/CallPeakUnit.pyx":858
 *         k = 1                           # rank
 *         f = -log10(N)
 *         pre_v = -2147483647             # <<<<<<<<<<<<<<
 *         pre_l = 0
 *         pre_q = 2147483647              # save the previous q-value
 */
  __Pyx_TraceLine(858,0,__PYX_ERR(0, 858, __pyx_L1_error))
  __pyx_v_pre_v = -2147483647.0;

  /* "MACS2/IO/CallPeakUnit.pyx":859
 *         f = -log10(N)
 *         pre_v = -2147483647
 *         pre_l = 0             # <<<<<<<<<<<<<<
 *         pre_q = 2147483647              # save the previous q-value
 * 
 */
  __Pyx_TraceLine(859,0,__PYX_ERR(0, 859, __pyx_L1_error))
  __pyx_v_pre_l = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":860
 *         pre_v = -2147483647
 *         pre_l = 0
 *         pre_q = 2147483647              # save the previous q-value             # <<<<<<<<<<<<<<
 * 
 *         self.pqtable = {}
 */
  __Pyx_TraceLine(860,0,__PYX_ERR(0, 860, __pyx_L1_error))
  __pyx_v_pre_q = 2147483647.0;

  /* "MACS2/IO/CallPeakUnit.pyx":862
 *         pre_q = 2147483647              # save the previous q-value
 * 
 *         self.pqtable = {}             # <<<<<<<<<<<<<<
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)
 *         for i in range(len(unique_values)):
 */
  __Pyx_TraceLine(862,0,__PYX_ERR(0, 862, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 862, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_GIVEREF(__pyx_t_4);
  __Pyx_GOTREF(__pyx_v_self->pqtable);
  __Pyx_DECREF(__pyx_v_self->pqtable);
  __pyx_v_self->pqtable = ((PyObject*)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":863
 * 
 *         self.pqtable = {}
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)             # <<<<<<<<<<<<<<
 *         for i in range(len(unique_values)):
 *             v = unique_values[i]
 */
  __Pyx_TraceLine(863,0,__PYX_ERR(0, 863, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyDict_Keys(__pyx_v_pvalue_stat); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 863, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_3 = PySequence_List(__pyx_t_4); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 863, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_4 = PyTuple_New(1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 863, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_GIVEREF(__pyx_t_3);
  PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_3);
  __pyx_t_3 = 0;
  __pyx_t_3 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 863, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_t_3, __pyx_n_s_reverse, Py_True) < 0) __PYX_ERR(0, 863, __pyx_L1_error)
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_sorted, __pyx_t_4, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 863, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(PyList_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 863, __pyx_L1_error)
  __pyx_v_unique_values = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":864
 *         self.pqtable = {}
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)
 *         for i in range(len(unique_values)):             # <<<<<<<<<<<<<<
 *             v = unique_values[i]
 *             l = pvalue_stat[v]
 */
  __Pyx_TraceLine(864,0,__PYX_ERR(0, 864, __pyx_L1_error))
  if (unlikely(__pyx_v_unique_values == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 864, __pyx_L1_error)
  }
  __pyx_t_5 = PyList_GET_SIZE(__pyx_v_unique_values); if (unlikely(__pyx_t_5 == ((Py_ssize_t)-1))) __PYX_ERR(0, 864, __pyx_L1_error)
  __pyx_t_7 = __pyx_t_5;
  for (__pyx_t_8 = 0; __pyx_t_8 < __pyx_t_7; __pyx_t_8+=1) {
    __pyx_v_i = __pyx_t_8;

    /* "MACS2/IO/CallPeakUnit.pyx":865
 *         unique_values = sorted(list(pvalue_stat.keys()), reverse=True) #sorted(unique_values,reverse=True)
 *         for i in range(len(unique_values)):
 *             v = unique_values[i]             # <<<<<<<<<<<<<<
 *             l = pvalue_stat[v]
 *             q = v + (log10(k) + f)
 */
    __Pyx_TraceLine(865,0,__PYX_ERR(0, 865, __pyx_L1_error))
    if (unlikely(__pyx_v_unique_values == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 865, __pyx_L1_error)
    }
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_unique_values, __pyx_v_i, __pyx_t_5numpy_int64_t, 1, __Pyx_PyInt_From_npy_int64, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 865, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_12 = __pyx_PyFloat_AsFloat(__pyx_t_1); if (unlikely((__pyx_t_12 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 865, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_v = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":866
 *         for i in range(len(unique_values)):
 *             v = unique_values[i]
 *             l = pvalue_stat[v]             # <<<<<<<<<<<<<<
 *             q = v + (log10(k) + f)
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 */
    __Pyx_TraceLine(866,0,__PYX_ERR(0, 866, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_v); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 866, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_3 = __Pyx_PyDict_GetItem(__pyx_v_pvalue_stat, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 866, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_11 = __Pyx_PyInt_As_npy_int64(__pyx_t_3); if (unlikely((__pyx_t_11 == ((npy_int64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 866, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_v_l = __pyx_t_11;

    /* "MACS2/IO/CallPeakUnit.pyx":867
 *             v = unique_values[i]
 *             l = pvalue_stat[v]
 *             q = v + (log10(k) + f)             # <<<<<<<<<<<<<<
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 *             self.pqtable[ v ] = q
 */
    __Pyx_TraceLine(867,0,__PYX_ERR(0, 867, __pyx_L1_error))
    __pyx_v_q = (__pyx_v_v + (log10(__pyx_v_k) + __pyx_v_f));

    /* "MACS2/IO/CallPeakUnit.pyx":868
 *             l = pvalue_stat[v]
 *             q = v + (log10(k) + f)
 *             q = max(0,min(pre_q,q))           # make q-score monotonic             # <<<<<<<<<<<<<<
 *             self.pqtable[ v ] = q
 *             pre_v = v
 */
    __Pyx_TraceLine(868,0,__PYX_ERR(0, 868, __pyx_L1_error))
    __pyx_t_12 = __pyx_v_q;
    __pyx_t_22 = __pyx_v_pre_q;
    if (((__pyx_t_12 < __pyx_t_22) != 0)) {
      __pyx_t_23 = __pyx_t_12;
    } else {
      __pyx_t_23 = __pyx_t_22;
    }
    __pyx_t_12 = __pyx_t_23;
    __pyx_t_14 = 0;
    if (((__pyx_t_12 > __pyx_t_14) != 0)) {
      __pyx_t_23 = __pyx_t_12;
    } else {
      __pyx_t_23 = __pyx_t_14;
    }
    __pyx_v_q = __pyx_t_23;

    /* "MACS2/IO/CallPeakUnit.pyx":869
 *             q = v + (log10(k) + f)
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 *             self.pqtable[ v ] = q             # <<<<<<<<<<<<<<
 *             pre_v = v
 *             pre_q = q
 */
    __Pyx_TraceLine(869,0,__PYX_ERR(0, 869, __pyx_L1_error))
    __pyx_t_3 = PyFloat_FromDouble(__pyx_v_q); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 869, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    if (unlikely(__pyx_v_self->pqtable == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 869, __pyx_L1_error)
    }
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_v); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 869, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (unlikely(PyDict_SetItem(__pyx_v_self->pqtable, __pyx_t_1, __pyx_t_3) < 0)) __PYX_ERR(0, 869, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":870
 *             q = max(0,min(pre_q,q))           # make q-score monotonic
 *             self.pqtable[ v ] = q
 *             pre_v = v             # <<<<<<<<<<<<<<
 *             pre_q = q
 *             k+=l
 */
    __Pyx_TraceLine(870,0,__PYX_ERR(0, 870, __pyx_L1_error))
    __pyx_v_pre_v = __pyx_v_v;

    /* "MACS2/IO/CallPeakUnit.pyx":871
 *             self.pqtable[ v ] = q
 *             pre_v = v
 *             pre_q = q             # <<<<<<<<<<<<<<
 *             k+=l
 *             nhcal += 1
 */
    __Pyx_TraceLine(871,0,__PYX_ERR(0, 871, __pyx_L1_error))
    __pyx_v_pre_q = __pyx_v_q;

    /* "MACS2/IO/CallPeakUnit.pyx":872
 *             pre_v = v
 *             pre_q = q
 *             k+=l             # <<<<<<<<<<<<<<
 *             nhcal += 1
 * 
 */
    __Pyx_TraceLine(872,0,__PYX_ERR(0, 872, __pyx_L1_error))
    __pyx_v_k = (__pyx_v_k + __pyx_v_l);

    /* "MACS2/IO/CallPeakUnit.pyx":873
 *             pre_q = q
 *             k+=l
 *             nhcal += 1             # <<<<<<<<<<<<<<
 * 
 *         logging.debug( "access pq hash for %d times" % nhcal )
 */
    __Pyx_TraceLine(873,0,__PYX_ERR(0, 873, __pyx_L1_error))
    __pyx_v_nhcal = (__pyx_v_nhcal + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":875
 *             nhcal += 1
 * 
 *         logging.debug( "access pq hash for %d times" % nhcal )             # <<<<<<<<<<<<<<
 * 
 *         # write pvalue and total length of predicted peaks
 */
  __Pyx_TraceLine(875,0,__PYX_ERR(0, 875, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_logging); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_debug); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_npy_int64(__pyx_v_nhcal); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = PyUnicode_Format(__pyx_kp_u_access_pq_hash_for_d_times, __pyx_t_1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_4))) {
    __pyx_t_1 = PyMethod_GET_SELF(__pyx_t_4);
    if (likely(__pyx_t_1)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
      __Pyx_INCREF(__pyx_t_1);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_4, function);
    }
  }
  __pyx_t_3 = (__pyx_t_1) ? __Pyx_PyObject_Call2Args(__pyx_t_4, __pyx_t_1, __pyx_t_2) : __Pyx_PyObject_CallOneArg(__pyx_t_4, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 875, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":878
 * 
 *         # write pvalue and total length of predicted peaks
 *         fhd = open( self.cutoff_analysis_filename, "w" )             # <<<<<<<<<<<<<<
 *         fhd.write( "pscore\tqscore\tnpeaks\tlpeaks\tavelpeak\n" )
 *         x = []
 */
  __Pyx_TraceLine(878,0,__PYX_ERR(0, 878, __pyx_L1_error))
  __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 878, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_INCREF(__pyx_v_self->cutoff_analysis_filename);
  __Pyx_GIVEREF(__pyx_v_self->cutoff_analysis_filename);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_self->cutoff_analysis_filename);
  __Pyx_INCREF(__pyx_n_u_w);
  __Pyx_GIVEREF(__pyx_n_u_w);
  PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_n_u_w);
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_builtin_open, __pyx_t_3, NULL); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 878, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_fhd = __pyx_t_4;
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":879
 *         # write pvalue and total length of predicted peaks
 *         fhd = open( self.cutoff_analysis_filename, "w" )
 *         fhd.write( "pscore\tqscore\tnpeaks\tlpeaks\tavelpeak\n" )             # <<<<<<<<<<<<<<
 *         x = []
 *         y = []
 */
  __Pyx_TraceLine(879,0,__PYX_ERR(0, 879, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_v_fhd, __pyx_n_s_write); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 879, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_2 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
    }
  }
  __pyx_t_4 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_2, __pyx_kp_u_pscore_qscore_npeaks_lpeaks_avel) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_kp_u_pscore_qscore_npeaks_lpeaks_avel);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 879, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":880
 *         fhd = open( self.cutoff_analysis_filename, "w" )
 *         fhd.write( "pscore\tqscore\tnpeaks\tlpeaks\tavelpeak\n" )
 *         x = []             # <<<<<<<<<<<<<<
 *         y = []
 *         for cutoff in tmplist:
 */
  __Pyx_TraceLine(880,0,__PYX_ERR(0, 880, __pyx_L1_error))
  __pyx_t_4 = PyList_New(0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 880, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_v_x = ((PyObject*)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":881
 *         fhd.write( "pscore\tqscore\tnpeaks\tlpeaks\tavelpeak\n" )
 *         x = []
 *         y = []             # <<<<<<<<<<<<<<
 *         for cutoff in tmplist:
 *             fhd.write( "%.2f\t%.2f\t%d\t%d\t%.2f\n" % ( cutoff, self.pqtable[ cutoff ], self.pvalue_npeaks[ cutoff ], self.pvalue_length[ cutoff ], self.pvalue_length[ cutoff ]/self.pvalue_npeaks[ cutoff ] ) )
 */
  __Pyx_TraceLine(881,0,__PYX_ERR(0, 881, __pyx_L1_error))
  __pyx_t_4 = PyList_New(0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 881, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_v_y = ((PyObject*)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":882
 *         x = []
 *         y = []
 *         for cutoff in tmplist:             # <<<<<<<<<<<<<<
 *             fhd.write( "%.2f\t%.2f\t%d\t%d\t%.2f\n" % ( cutoff, self.pqtable[ cutoff ], self.pvalue_npeaks[ cutoff ], self.pvalue_length[ cutoff ], self.pvalue_length[ cutoff ]/self.pvalue_npeaks[ cutoff ] ) )
 *             x.append( cutoff )
 */
  __Pyx_TraceLine(882,0,__PYX_ERR(0, 882, __pyx_L1_error))
  __pyx_t_4 = __pyx_v_tmplist; __Pyx_INCREF(__pyx_t_4); __pyx_t_5 = 0;
  for (;;) {
    if (__pyx_t_5 >= PyList_GET_SIZE(__pyx_t_4)) break;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_3 = PyList_GET_ITEM(__pyx_t_4, __pyx_t_5); __Pyx_INCREF(__pyx_t_3); __pyx_t_5++; if (unlikely(0 < 0)) __PYX_ERR(0, 882, __pyx_L1_error)
    #else
    __pyx_t_3 = PySequence_ITEM(__pyx_t_4, __pyx_t_5); __pyx_t_5++; if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 882, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    #endif
    __pyx_t_23 = __pyx_PyFloat_AsFloat(__pyx_t_3); if (unlikely((__pyx_t_23 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 882, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_v_cutoff = __pyx_t_23;

    /* "MACS2/IO/CallPeakUnit.pyx":883
 *         y = []
 *         for cutoff in tmplist:
 *             fhd.write( "%.2f\t%.2f\t%d\t%d\t%.2f\n" % ( cutoff, self.pqtable[ cutoff ], self.pvalue_npeaks[ cutoff ], self.pvalue_length[ cutoff ], self.pvalue_length[ cutoff ]/self.pvalue_npeaks[ cutoff ] ) )             # <<<<<<<<<<<<<<
 *             x.append( cutoff )
 *             y.append( self.pvalue_length[ cutoff ] )
 */
    __Pyx_TraceLine(883,0,__PYX_ERR(0, 883, __pyx_L1_error))
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_fhd, __pyx_n_s_write); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_1 = PyTuple_New(10); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_7 = 0;
    __pyx_t_24 = 127;
    __pyx_t_25 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_25)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_25);
    __pyx_t_26 = __Pyx_PyObject_Format(__pyx_t_25, __pyx_kp_u_2f); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __Pyx_DECREF(__pyx_t_25); __pyx_t_25 = 0;
    __pyx_t_24 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) > __pyx_t_24) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) : __pyx_t_24;
    __pyx_t_7 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_26);
    __Pyx_GIVEREF(__pyx_t_26);
    PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_t_26);
    __pyx_t_26 = 0;
    __Pyx_INCREF(__pyx_kp_u__9);
    __pyx_t_7 += 1;
    __Pyx_GIVEREF(__pyx_kp_u__9);
    PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_kp_u__9);
    if (unlikely(__pyx_v_self->pqtable == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 883, __pyx_L1_error)
    }
    __pyx_t_26 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __pyx_t_25 = __Pyx_PyDict_GetItem(__pyx_v_self->pqtable, __pyx_t_26); if (unlikely(!__pyx_t_25)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_25);
    __Pyx_DECREF(__pyx_t_26); __pyx_t_26 = 0;
    __pyx_t_26 = __Pyx_PyObject_Format(__pyx_t_25, __pyx_kp_u_2f); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __Pyx_DECREF(__pyx_t_25); __pyx_t_25 = 0;
    __pyx_t_24 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) > __pyx_t_24) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) : __pyx_t_24;
    __pyx_t_7 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_26);
    __Pyx_GIVEREF(__pyx_t_26);
    PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_t_26);
    __pyx_t_26 = 0;
    __Pyx_INCREF(__pyx_kp_u__9);
    __pyx_t_7 += 1;
    __Pyx_GIVEREF(__pyx_kp_u__9);
    PyTuple_SET_ITEM(__pyx_t_1, 3, __pyx_kp_u__9);
    if (unlikely(__pyx_v_self->pvalue_npeaks == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 883, __pyx_L1_error)
    }
    __pyx_t_26 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __pyx_t_25 = __Pyx_PyDict_GetItem(__pyx_v_self->pvalue_npeaks, __pyx_t_26); if (unlikely(!__pyx_t_25)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_25);
    __Pyx_DECREF(__pyx_t_26); __pyx_t_26 = 0;
    __pyx_t_26 = __Pyx_PyObject_Format(__pyx_t_25, __pyx_n_u_d); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __Pyx_DECREF(__pyx_t_25); __pyx_t_25 = 0;
    __pyx_t_24 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) > __pyx_t_24) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) : __pyx_t_24;
    __pyx_t_7 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_26);
    __Pyx_GIVEREF(__pyx_t_26);
    PyTuple_SET_ITEM(__pyx_t_1, 4, __pyx_t_26);
    __pyx_t_26 = 0;
    __Pyx_INCREF(__pyx_kp_u__9);
    __pyx_t_7 += 1;
    __Pyx_GIVEREF(__pyx_kp_u__9);
    PyTuple_SET_ITEM(__pyx_t_1, 5, __pyx_kp_u__9);
    if (unlikely(__pyx_v_self->pvalue_length == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 883, __pyx_L1_error)
    }
    __pyx_t_26 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __pyx_t_25 = __Pyx_PyDict_GetItem(__pyx_v_self->pvalue_length, __pyx_t_26); if (unlikely(!__pyx_t_25)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_25);
    __Pyx_DECREF(__pyx_t_26); __pyx_t_26 = 0;
    __pyx_t_26 = __Pyx_PyObject_Format(__pyx_t_25, __pyx_n_u_d); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __Pyx_DECREF(__pyx_t_25); __pyx_t_25 = 0;
    __pyx_t_24 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) > __pyx_t_24) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_26) : __pyx_t_24;
    __pyx_t_7 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_26);
    __Pyx_GIVEREF(__pyx_t_26);
    PyTuple_SET_ITEM(__pyx_t_1, 6, __pyx_t_26);
    __pyx_t_26 = 0;
    __Pyx_INCREF(__pyx_kp_u__9);
    __pyx_t_7 += 1;
    __Pyx_GIVEREF(__pyx_kp_u__9);
    PyTuple_SET_ITEM(__pyx_t_1, 7, __pyx_kp_u__9);
    if (unlikely(__pyx_v_self->pvalue_length == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 883, __pyx_L1_error)
    }
    __pyx_t_26 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __pyx_t_25 = __Pyx_PyDict_GetItem(__pyx_v_self->pvalue_length, __pyx_t_26); if (unlikely(!__pyx_t_25)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_25);
    __Pyx_DECREF(__pyx_t_26); __pyx_t_26 = 0;
    if (unlikely(__pyx_v_self->pvalue_npeaks == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 883, __pyx_L1_error)
    }
    __pyx_t_26 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __pyx_t_27 = __Pyx_PyDict_GetItem(__pyx_v_self->pvalue_npeaks, __pyx_t_26); if (unlikely(!__pyx_t_27)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_27);
    __Pyx_DECREF(__pyx_t_26); __pyx_t_26 = 0;
    __pyx_t_26 = __Pyx_PyNumber_Divide(__pyx_t_25, __pyx_t_27); if (unlikely(!__pyx_t_26)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_26);
    __Pyx_DECREF(__pyx_t_25); __pyx_t_25 = 0;
    __Pyx_DECREF(__pyx_t_27); __pyx_t_27 = 0;
    __pyx_t_27 = __Pyx_PyObject_Format(__pyx_t_26, __pyx_kp_u_2f); if (unlikely(!__pyx_t_27)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_27);
    __Pyx_DECREF(__pyx_t_26); __pyx_t_26 = 0;
    __pyx_t_24 = (__Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_27) > __pyx_t_24) ? __Pyx_PyUnicode_MAX_CHAR_VALUE(__pyx_t_27) : __pyx_t_24;
    __pyx_t_7 += __Pyx_PyUnicode_GET_LENGTH(__pyx_t_27);
    __Pyx_GIVEREF(__pyx_t_27);
    PyTuple_SET_ITEM(__pyx_t_1, 8, __pyx_t_27);
    __pyx_t_27 = 0;
    __Pyx_INCREF(__pyx_kp_u__10);
    __pyx_t_7 += 1;
    __Pyx_GIVEREF(__pyx_kp_u__10);
    PyTuple_SET_ITEM(__pyx_t_1, 9, __pyx_kp_u__10);
    __pyx_t_27 = __Pyx_PyUnicode_Join(__pyx_t_1, 10, __pyx_t_7, __pyx_t_24); if (unlikely(!__pyx_t_27)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_27);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_1 = NULL;
    if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_1 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_1)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_1);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
      }
    }
    __pyx_t_3 = (__pyx_t_1) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_1, __pyx_t_27) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_27);
    __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_27); __pyx_t_27 = 0;
    if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 883, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":884
 *         for cutoff in tmplist:
 *             fhd.write( "%.2f\t%.2f\t%d\t%d\t%.2f\n" % ( cutoff, self.pqtable[ cutoff ], self.pvalue_npeaks[ cutoff ], self.pvalue_length[ cutoff ], self.pvalue_length[ cutoff ]/self.pvalue_npeaks[ cutoff ] ) )
 *             x.append( cutoff )             # <<<<<<<<<<<<<<
 *             y.append( self.pvalue_length[ cutoff ] )
 *         fhd.close()
 */
    __Pyx_TraceLine(884,0,__PYX_ERR(0, 884, __pyx_L1_error))
    __pyx_t_3 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 884, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_17 = __Pyx_PyList_Append(__pyx_v_x, __pyx_t_3); if (unlikely(__pyx_t_17 == ((int)-1))) __PYX_ERR(0, 884, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":885
 *             fhd.write( "%.2f\t%.2f\t%d\t%d\t%.2f\n" % ( cutoff, self.pqtable[ cutoff ], self.pvalue_npeaks[ cutoff ], self.pvalue_length[ cutoff ], self.pvalue_length[ cutoff ]/self.pvalue_npeaks[ cutoff ] ) )
 *             x.append( cutoff )
 *             y.append( self.pvalue_length[ cutoff ] )             # <<<<<<<<<<<<<<
 *         fhd.close()
 *         logging.info( "#3 Analysis of cutoff vs num of peaks or total length has been saved in %s" % self.cutoff_analysis_filename )
 */
    __Pyx_TraceLine(885,0,__PYX_ERR(0, 885, __pyx_L1_error))
    if (unlikely(__pyx_v_self->pvalue_length == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 885, __pyx_L1_error)
    }
    __pyx_t_3 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 885, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_2 = __Pyx_PyDict_GetItem(__pyx_v_self->pvalue_length, __pyx_t_3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 885, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_17 = __Pyx_PyList_Append(__pyx_v_y, __pyx_t_2); if (unlikely(__pyx_t_17 == ((int)-1))) __PYX_ERR(0, 885, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":882
 *         x = []
 *         y = []
 *         for cutoff in tmplist:             # <<<<<<<<<<<<<<
 *             fhd.write( "%.2f\t%.2f\t%d\t%d\t%.2f\n" % ( cutoff, self.pqtable[ cutoff ], self.pvalue_npeaks[ cutoff ], self.pvalue_length[ cutoff ], self.pvalue_length[ cutoff ]/self.pvalue_npeaks[ cutoff ] ) )
 *             x.append( cutoff )
 */
    __Pyx_TraceLine(882,0,__PYX_ERR(0, 882, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":886
 *             x.append( cutoff )
 *             y.append( self.pvalue_length[ cutoff ] )
 *         fhd.close()             # <<<<<<<<<<<<<<
 *         logging.info( "#3 Analysis of cutoff vs num of peaks or total length has been saved in %s" % self.cutoff_analysis_filename )
 *         #logging.info( "#3 Suggest a cutoff..." )
 */
  __Pyx_TraceLine(886,0,__PYX_ERR(0, 886, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_fhd, __pyx_n_s_close); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 886, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_4 = (__pyx_t_3) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_3) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 886, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":887
 *             y.append( self.pvalue_length[ cutoff ] )
 *         fhd.close()
 *         logging.info( "#3 Analysis of cutoff vs num of peaks or total length has been saved in %s" % self.cutoff_analysis_filename )             # <<<<<<<<<<<<<<
 *         #logging.info( "#3 Suggest a cutoff..." )
 *         #optimal_cutoff, optimal_length = find_optimal_cutoff( x, y )
 */
  __Pyx_TraceLine(887,0,__PYX_ERR(0, 887, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 887, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 887, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = PyUnicode_Format(__pyx_kp_u_3_Analysis_of_cutoff_vs_num_of, __pyx_v_self->cutoff_analysis_filename); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 887, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_27 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
    __pyx_t_27 = PyMethod_GET_SELF(__pyx_t_3);
    if (likely(__pyx_t_27)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_27);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_3, function);
    }
  }
  __pyx_t_4 = (__pyx_t_27) ? __Pyx_PyObject_Call2Args(__pyx_t_3, __pyx_t_27, __pyx_t_2) : __Pyx_PyObject_CallOneArg(__pyx_t_3, __pyx_t_2);
  __Pyx_XDECREF(__pyx_t_27); __pyx_t_27 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 887, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":894
 *         #print (list(self.pvalue_length.keys()))
 *         #print (list(self.pvalue_npeaks.keys()))
 *         return             # <<<<<<<<<<<<<<
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,
 */
  __Pyx_TraceLine(894,0,__PYX_ERR(0, 894, __pyx_L1_error))
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":736
 * 
 * 
 *     cdef void __pre_computes ( self, int32_t max_gap = 50, int32_t min_length = 200 ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.pqtable and self.pvalue_length is built. All
 *         chromosomes will be iterated. So it will take some time.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_25);
  __Pyx_XDECREF(__pyx_t_26);
  __Pyx_XDECREF(__pyx_t_27);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.CallerFromAlignments.__pre_computes", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_chrom);
  __Pyx_XDECREF((PyObject *)__pyx_v_pos_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_treat_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_ctrl_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_score_array);
  __Pyx_XDECREF(__pyx_v_pvalue_stat);
  __Pyx_XDECREF(__pyx_v_unique_values);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_endpos);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_startpos);
  __Pyx_XDECREF(__pyx_v_peak_content);
  __Pyx_XDECREF(__pyx_v_tmplist);
  __Pyx_XDECREF(__pyx_v_lastp);
  __Pyx_XDECREF(__pyx_v_tl);
  __Pyx_XDECREF(__pyx_v_fhd);
  __Pyx_XDECREF(__pyx_v_x);
  __Pyx_XDECREF(__pyx_v_y);
  __Pyx_XDECREF(__pyx_8genexpr3__pyx_v_x);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "MACS2/IO/CallPeakUnit.pyx":896
 *         return
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,             # <<<<<<<<<<<<<<
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 */

static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_9call_peaks(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_score_cutoff_s, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks *__pyx_optional_args) {
  __pyx_t_5numpy_int32_t __pyx_v_min_length = ((__pyx_t_5numpy_int32_t)0xC8);
  __pyx_t_5numpy_int32_t __pyx_v_max_gap = ((__pyx_t_5numpy_int32_t)50);

  /* "MACS2/IO/CallPeakUnit.pyx":897
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):             # <<<<<<<<<<<<<<
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 * 
 */
  PyBoolObject *__pyx_v_call_summits = ((PyBoolObject *)Py_False);
  PyBoolObject *__pyx_v_cutoff_analysis = ((PyBoolObject *)Py_False);
  PyObject *__pyx_v_chrom = 0;
  PyObject *__pyx_v_tmp_bytes = 0;
  PyObject *__pyx_v_peaks = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  int __pyx_t_7;
  PyObject *__pyx_t_8 = NULL;
  int __pyx_t_9;
  int __pyx_t_10;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes __pyx_t_11;
  char const *__pyx_t_12;
  char const *__pyx_t_13;
  Py_ssize_t __pyx_t_14;
  __Pyx_RefNannySetupContext("call_peaks", 0);
  __Pyx_TraceCall("call_peaks", __pyx_f[0], 896, 0, __PYX_ERR(0, 896, __pyx_L1_error));
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_min_length = __pyx_optional_args->min_length;
      if (__pyx_optional_args->__pyx_n > 1) {
        __pyx_v_max_gap = __pyx_optional_args->max_gap;
        if (__pyx_optional_args->__pyx_n > 2) {
          __pyx_v_call_summits = __pyx_optional_args->call_summits;
          if (__pyx_optional_args->__pyx_n > 3) {
            __pyx_v_cutoff_analysis = __pyx_optional_args->cutoff_analysis;
          }
        }
      }
    }
  }

  /* "MACS2/IO/CallPeakUnit.pyx":896
 *         return
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,             # <<<<<<<<<<<<<<
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 */
  __Pyx_TraceLine(896,0,__PYX_ERR(0, 896, __pyx_L1_error))
  /* Check if called by wrapper */
  if (unlikely(__pyx_skip_dispatch)) ;
  /* Check if overridden in Python */
  else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || (Py_TYPE(((PyObject *)__pyx_v_self))->tp_flags & (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
    #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
    if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
      PY_UINT64_T __pyx_type_dict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      #endif
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_call_peaks); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 896, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (!PyCFunction_Check(__pyx_t_1) || (PyCFunction_GET_FUNCTION(__pyx_t_1) != (PyCFunction)(void*)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_9call_peaks)) {
        __Pyx_XDECREF(__pyx_r);
        __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_min_length); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 896, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_4 = __Pyx_PyInt_From_npy_int32(__pyx_v_max_gap); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 896, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __Pyx_INCREF(__pyx_t_1);
        __pyx_t_5 = __pyx_t_1; __pyx_t_6 = NULL;
        __pyx_t_7 = 0;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
          __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_5);
          if (likely(__pyx_t_6)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
            __Pyx_INCREF(__pyx_t_6);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_5, function);
            __pyx_t_7 = 1;
          }
        }
        #if CYTHON_FAST_PYCALL
        if (PyFunction_Check(__pyx_t_5)) {
          PyObject *__pyx_temp[7] = {__pyx_t_6, __pyx_v_scoring_function_symbols, __pyx_v_score_cutoff_s, __pyx_t_3, __pyx_t_4, ((PyObject *)__pyx_v_call_summits), ((PyObject *)__pyx_v_cutoff_analysis)};
          __pyx_t_2 = __Pyx_PyFunction_FastCall(__pyx_t_5, __pyx_temp+1-__pyx_t_7, 6+__pyx_t_7); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 896, __pyx_L1_error)
          __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        } else
        #endif
        #if CYTHON_FAST_PYCCALL
        if (__Pyx_PyFastCFunction_Check(__pyx_t_5)) {
          PyObject *__pyx_temp[7] = {__pyx_t_6, __pyx_v_scoring_function_symbols, __pyx_v_score_cutoff_s, __pyx_t_3, __pyx_t_4, ((PyObject *)__pyx_v_call_summits), ((PyObject *)__pyx_v_cutoff_analysis)};
          __pyx_t_2 = __Pyx_PyCFunction_FastCall(__pyx_t_5, __pyx_temp+1-__pyx_t_7, 6+__pyx_t_7); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 896, __pyx_L1_error)
          __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        } else
        #endif
        {
          __pyx_t_8 = PyTuple_New(6+__pyx_t_7); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 896, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_8);
          if (__pyx_t_6) {
            __Pyx_GIVEREF(__pyx_t_6); PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_t_6); __pyx_t_6 = NULL;
          }
          __Pyx_INCREF(__pyx_v_scoring_function_symbols);
          __Pyx_GIVEREF(__pyx_v_scoring_function_symbols);
          PyTuple_SET_ITEM(__pyx_t_8, 0+__pyx_t_7, __pyx_v_scoring_function_symbols);
          __Pyx_INCREF(__pyx_v_score_cutoff_s);
          __Pyx_GIVEREF(__pyx_v_score_cutoff_s);
          PyTuple_SET_ITEM(__pyx_t_8, 1+__pyx_t_7, __pyx_v_score_cutoff_s);
          __Pyx_GIVEREF(__pyx_t_3);
          PyTuple_SET_ITEM(__pyx_t_8, 2+__pyx_t_7, __pyx_t_3);
          __Pyx_GIVEREF(__pyx_t_4);
          PyTuple_SET_ITEM(__pyx_t_8, 3+__pyx_t_7, __pyx_t_4);
          __Pyx_INCREF(((PyObject *)__pyx_v_call_summits));
          __Pyx_GIVEREF(((PyObject *)__pyx_v_call_summits));
          PyTuple_SET_ITEM(__pyx_t_8, 4+__pyx_t_7, ((PyObject *)__pyx_v_call_summits));
          __Pyx_INCREF(((PyObject *)__pyx_v_cutoff_analysis));
          __Pyx_GIVEREF(((PyObject *)__pyx_v_cutoff_analysis));
          PyTuple_SET_ITEM(__pyx_t_8, 5+__pyx_t_7, ((PyObject *)__pyx_v_cutoff_analysis));
          __pyx_t_3 = 0;
          __pyx_t_4 = 0;
          __pyx_t_2 = __Pyx_PyObject_Call(__pyx_t_5, __pyx_t_8, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 896, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        }
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        __pyx_r = __pyx_t_2;
        __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        goto __pyx_L0;
      }
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
      __pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      __pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
      if (unlikely(__pyx_type_dict_guard != __pyx_tp_dict_version)) {
        __pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
      }
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    }
    #endif
  }

  /* "MACS2/IO/CallPeakUnit.pyx":911
 *             bytes tmp_bytes
 * 
 *         peaks = PeakIO()             # <<<<<<<<<<<<<<
 * 
 *         # prepare p-q table
 */
  __Pyx_TraceLine(911,0,__PYX_ERR(0, 911, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_PeakIO); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 911, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_5 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_5)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_5);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_1 = (__pyx_t_5) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_5) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 911, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_v_peaks = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":914
 * 
 *         # prepare p-q table
 *         if not self.pqtable:             # <<<<<<<<<<<<<<
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:
 */
  __Pyx_TraceLine(914,0,__PYX_ERR(0, 914, __pyx_L1_error))
  __pyx_t_9 = __Pyx_PyObject_IsTrue(__pyx_v_self->pqtable); if (unlikely(__pyx_t_9 < 0)) __PYX_ERR(0, 914, __pyx_L1_error)
  __pyx_t_10 = ((!__pyx_t_9) != 0);
  if (__pyx_t_10) {

    /* "MACS2/IO/CallPeakUnit.pyx":915
 *         # prepare p-q table
 *         if not self.pqtable:
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")             # <<<<<<<<<<<<<<
 *             if cutoff_analysis:
 *                 logging.info("#3 Cutoff vs peaks called will be analyzed!")
 */
    __Pyx_TraceLine(915,0,__PYX_ERR(0, 915, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 915, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 915, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_5, function);
      }
    }
    __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_2, __pyx_kp_u_3_Pre_compute_pvalue_qvalue_tab) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_kp_u_3_Pre_compute_pvalue_qvalue_tab);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 915, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":916
 *         if not self.pqtable:
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:             # <<<<<<<<<<<<<<
 *                 logging.info("#3 Cutoff vs peaks called will be analyzed!")
 *                 self.__pre_computes( max_gap = max_gap, min_length = min_length )
 */
    __Pyx_TraceLine(916,0,__PYX_ERR(0, 916, __pyx_L1_error))
    __pyx_t_10 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_cutoff_analysis)); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 916, __pyx_L1_error)
    if (__pyx_t_10) {

      /* "MACS2/IO/CallPeakUnit.pyx":917
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:
 *                 logging.info("#3 Cutoff vs peaks called will be analyzed!")             # <<<<<<<<<<<<<<
 *                 self.__pre_computes( max_gap = max_gap, min_length = min_length )
 *             else:
 */
      __Pyx_TraceLine(917,0,__PYX_ERR(0, 917, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_logging); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 917, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_info); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 917, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_5 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
        __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_2);
        if (likely(__pyx_t_5)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
          __Pyx_INCREF(__pyx_t_5);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_2, function);
        }
      }
      __pyx_t_1 = (__pyx_t_5) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_5, __pyx_kp_u_3_Cutoff_vs_peaks_called_will_b) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_kp_u_3_Cutoff_vs_peaks_called_will_b);
      __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 917, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":918
 *             if cutoff_analysis:
 *                 logging.info("#3 Cutoff vs peaks called will be analyzed!")
 *                 self.__pre_computes( max_gap = max_gap, min_length = min_length )             # <<<<<<<<<<<<<<
 *             else:
 *                 self.__cal_pvalue_qvalue_table()
 */
      __Pyx_TraceLine(918,0,__PYX_ERR(0, 918, __pyx_L1_error))
      __pyx_t_11.__pyx_n = 2;
      __pyx_t_11.max_gap = __pyx_v_max_gap;
      __pyx_t_11.min_length = __pyx_v_min_length;
      ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___pre_computes(__pyx_v_self, &__pyx_t_11); 

      /* "MACS2/IO/CallPeakUnit.pyx":916
 *         if not self.pqtable:
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:             # <<<<<<<<<<<<<<
 *                 logging.info("#3 Cutoff vs peaks called will be analyzed!")
 *                 self.__pre_computes( max_gap = max_gap, min_length = min_length )
 */
      goto __pyx_L4;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":920
 *                 self.__pre_computes( max_gap = max_gap, min_length = min_length )
 *             else:
 *                 self.__cal_pvalue_qvalue_table()             # <<<<<<<<<<<<<<
 * 
 * 
 */
    __Pyx_TraceLine(920,0,__PYX_ERR(0, 920, __pyx_L1_error))
    /*else*/ {
      ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_pvalue_qvalue_table(__pyx_v_self);
    }
    __pyx_L4:;

    /* "MACS2/IO/CallPeakUnit.pyx":914
 * 
 *         # prepare p-q table
 *         if not self.pqtable:             # <<<<<<<<<<<<<<
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":924
 * 
 *         # prepare bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )
 */
  __Pyx_TraceLine(924,0,__PYX_ERR(0, 924, __pyx_L1_error))
  __pyx_t_10 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->save_bedGraph)); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 924, __pyx_L1_error)
  if (__pyx_t_10) {

    /* "MACS2/IO/CallPeakUnit.pyx":925
 *         # prepare bedGraph file
 *         if self.save_bedGraph:
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )             # <<<<<<<<<<<<<<
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )
 * 
 */
    __Pyx_TraceLine(925,0,__PYX_ERR(0, 925, __pyx_L1_error))
    if (unlikely(__pyx_v_self->bedGraph_treat_filename == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 925, __pyx_L1_error)
    }
    __pyx_t_12 = __Pyx_PyBytes_AsString(__pyx_v_self->bedGraph_treat_filename); if (unlikely((!__pyx_t_12) && PyErr_Occurred())) __PYX_ERR(0, 925, __pyx_L1_error)
    __pyx_v_self->bedGraph_treat_f = fopen(__pyx_t_12, ((char const *)"w"));

    /* "MACS2/IO/CallPeakUnit.pyx":926
 *         if self.save_bedGraph:
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )             # <<<<<<<<<<<<<<
 * 
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")
 */
    __Pyx_TraceLine(926,0,__PYX_ERR(0, 926, __pyx_L1_error))
    if (unlikely(__pyx_v_self->bedGraph_control_filename == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 926, __pyx_L1_error)
    }
    __pyx_t_12 = __Pyx_PyBytes_AsString(__pyx_v_self->bedGraph_control_filename); if (unlikely((!__pyx_t_12) && PyErr_Occurred())) __PYX_ERR(0, 926, __pyx_L1_error)
    __pyx_v_self->bedGraph_ctrl_f = fopen(__pyx_t_12, ((char const *)"w"));

    /* "MACS2/IO/CallPeakUnit.pyx":928
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )
 * 
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")             # <<<<<<<<<<<<<<
 *             logging.info ("#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_treat_pileup.bdg")
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 */
    __Pyx_TraceLine(928,0,__PYX_ERR(0, 928, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 928, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 928, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_5, function);
      }
    }
    __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_2, __pyx_kp_u_3_In_the_peak_calling_step_the) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_kp_u_3_In_the_peak_calling_step_the);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 928, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":929
 * 
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")
 *             logging.info ("#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_treat_pileup.bdg")             # <<<<<<<<<<<<<<
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 * 
 */
    __Pyx_TraceLine(929,0,__PYX_ERR(0, 929, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_logging); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 929, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_info); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 929, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(__pyx_v_self->bedGraph_filename_prefix == Py_None)) {
      PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "decode");
      __PYX_ERR(0, 929, __pyx_L1_error)
    }
    __pyx_t_5 = __Pyx_decode_bytes(__pyx_v_self->bedGraph_filename_prefix, 0, PY_SSIZE_T_MAX, NULL, NULL, NULL); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 929, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_8 = PyUnicode_Format(__pyx_kp_u_3_Write_bedGraph_files_for_trea, __pyx_t_5); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 929, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __pyx_t_5 = __Pyx_PyUnicode_Concat(__pyx_t_8, __pyx_kp_u_treat_pileup_bdg); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 929, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_8 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_8 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_8)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_8);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
      }
    }
    __pyx_t_1 = (__pyx_t_8) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_8, __pyx_t_5) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_5);
    __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 929, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":930
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")
 *             logging.info ("#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_treat_pileup.bdg")
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")             # <<<<<<<<<<<<<<
 * 
 *             if self.save_SPMR:
 */
    __Pyx_TraceLine(930,0,__PYX_ERR(0, 930, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 930, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 930, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(__pyx_v_self->bedGraph_filename_prefix == Py_None)) {
      PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "decode");
      __PYX_ERR(0, 930, __pyx_L1_error)
    }
    __pyx_t_2 = __Pyx_decode_bytes(__pyx_v_self->bedGraph_filename_prefix, 0, PY_SSIZE_T_MAX, NULL, NULL, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 930, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_8 = PyUnicode_Format(__pyx_kp_u_3_Write_bedGraph_files_for_cont, __pyx_t_2); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 930, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyUnicode_Concat(__pyx_t_8, __pyx_kp_u_control_lambda_bdg); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 930, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_8 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
      __pyx_t_8 = PyMethod_GET_SELF(__pyx_t_5);
      if (likely(__pyx_t_8)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
        __Pyx_INCREF(__pyx_t_8);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_5, function);
      }
    }
    __pyx_t_1 = (__pyx_t_8) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_8, __pyx_t_2) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_2);
    __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 930, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":932
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 * 
 *             if self.save_SPMR:             # <<<<<<<<<<<<<<
 *                 logging.info ( "#3   --SPMR is requested, so pileup will be normalized by sequencing depth in million reads." )
 *             elif self.treat_scaling_factor == 1:
 */
    __Pyx_TraceLine(932,0,__PYX_ERR(0, 932, __pyx_L1_error))
    __pyx_t_10 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->save_SPMR)); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 932, __pyx_L1_error)
    if (__pyx_t_10) {

      /* "MACS2/IO/CallPeakUnit.pyx":933
 * 
 *             if self.save_SPMR:
 *                 logging.info ( "#3   --SPMR is requested, so pileup will be normalized by sequencing depth in million reads." )             # <<<<<<<<<<<<<<
 *             elif self.treat_scaling_factor == 1:
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in treatment." )
 */
      __Pyx_TraceLine(933,0,__PYX_ERR(0, 933, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_logging); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 933, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_info); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 933, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_5 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
        __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_2);
        if (likely(__pyx_t_5)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
          __Pyx_INCREF(__pyx_t_5);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_2, function);
        }
      }
      __pyx_t_1 = (__pyx_t_5) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_5, __pyx_kp_u_3_SPMR_is_requested_so_pileup_w) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_kp_u_3_SPMR_is_requested_so_pileup_w);
      __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 933, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":932
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 * 
 *             if self.save_SPMR:             # <<<<<<<<<<<<<<
 *                 logging.info ( "#3   --SPMR is requested, so pileup will be normalized by sequencing depth in million reads." )
 *             elif self.treat_scaling_factor == 1:
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":934
 *             if self.save_SPMR:
 *                 logging.info ( "#3   --SPMR is requested, so pileup will be normalized by sequencing depth in million reads." )
 *             elif self.treat_scaling_factor == 1:             # <<<<<<<<<<<<<<
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in treatment." )
 *             else:
 */
    __Pyx_TraceLine(934,0,__PYX_ERR(0, 934, __pyx_L1_error))
    __pyx_t_10 = ((__pyx_v_self->treat_scaling_factor == 1.0) != 0);
    if (__pyx_t_10) {

      /* "MACS2/IO/CallPeakUnit.pyx":935
 *                 logging.info ( "#3   --SPMR is requested, so pileup will be normalized by sequencing depth in million reads." )
 *             elif self.treat_scaling_factor == 1:
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in treatment." )             # <<<<<<<<<<<<<<
 *             else:
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in control." )
 */
      __Pyx_TraceLine(935,0,__PYX_ERR(0, 935, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 935, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 935, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_2 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
        __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
        if (likely(__pyx_t_2)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
          __Pyx_INCREF(__pyx_t_2);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_5, function);
        }
      }
      __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_2, __pyx_kp_u_3_Pileup_will_be_based_on_seque) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_kp_u_3_Pileup_will_be_based_on_seque);
      __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 935, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":934
 *             if self.save_SPMR:
 *                 logging.info ( "#3   --SPMR is requested, so pileup will be normalized by sequencing depth in million reads." )
 *             elif self.treat_scaling_factor == 1:             # <<<<<<<<<<<<<<
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in treatment." )
 *             else:
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":937
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in treatment." )
 *             else:
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in control." )             # <<<<<<<<<<<<<<
 * 
 *             if self.trackline:
 */
    __Pyx_TraceLine(937,0,__PYX_ERR(0, 937, __pyx_L1_error))
    /*else*/ {
      __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_logging); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 937, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_info); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 937, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_5 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
        __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_2);
        if (likely(__pyx_t_5)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
          __Pyx_INCREF(__pyx_t_5);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_2, function);
        }
      }
      __pyx_t_1 = (__pyx_t_5) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_5, __pyx_kp_u_3_Pileup_will_be_based_on_seque_2) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_kp_u_3_Pileup_will_be_based_on_seque_2);
      __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 937, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    }
    __pyx_L6:;

    /* "MACS2/IO/CallPeakUnit.pyx":939
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in control." )
 * 
 *             if self.trackline:             # <<<<<<<<<<<<<<
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 */
    __Pyx_TraceLine(939,0,__PYX_ERR(0, 939, __pyx_L1_error))
    __pyx_t_10 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->trackline)); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 939, __pyx_L1_error)
    if (__pyx_t_10) {

      /* "MACS2/IO/CallPeakUnit.pyx":941
 *             if self.trackline:
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()             # <<<<<<<<<<<<<<
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 */
      __Pyx_TraceLine(941,0,__PYX_ERR(0, 941, __pyx_L1_error))
      __pyx_t_1 = PyUnicode_Format(__pyx_kp_u_track_type_bedGraph_name_treatme, __pyx_v_self->bedGraph_filename_prefix); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 941, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_2 = PyUnicode_AsEncodedString(((PyObject*)__pyx_t_1), NULL, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 941, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_v_tmp_bytes = ((PyObject*)__pyx_t_2);
      __pyx_t_2 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":942
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )             # <<<<<<<<<<<<<<
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_ctrl_f, tmp_bytes )
 */
      __Pyx_TraceLine(942,0,__PYX_ERR(0, 942, __pyx_L1_error))
      if (unlikely(__pyx_v_tmp_bytes == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
        __PYX_ERR(0, 942, __pyx_L1_error)
      }
      __pyx_t_13 = __Pyx_PyBytes_AsString(__pyx_v_tmp_bytes); if (unlikely((!__pyx_t_13) && PyErr_Occurred())) __PYX_ERR(0, 942, __pyx_L1_error)
      (void)(fprintf(__pyx_v_self->bedGraph_treat_f, __pyx_t_13));

      /* "MACS2/IO/CallPeakUnit.pyx":943
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()             # <<<<<<<<<<<<<<
 *                 fprintf( self.bedGraph_ctrl_f, tmp_bytes )
 * 
 */
      __Pyx_TraceLine(943,0,__PYX_ERR(0, 943, __pyx_L1_error))
      __pyx_t_2 = PyUnicode_Format(__pyx_kp_u_track_type_bedGraph_name_control, __pyx_v_self->bedGraph_filename_prefix); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 943, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_1 = PyUnicode_AsEncodedString(((PyObject*)__pyx_t_2), NULL, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 943, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_DECREF_SET(__pyx_v_tmp_bytes, ((PyObject*)__pyx_t_1));
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":944
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_ctrl_f, tmp_bytes )             # <<<<<<<<<<<<<<
 * 
 *         logging.info("#3 Call peaks for each chromosome...")
 */
      __Pyx_TraceLine(944,0,__PYX_ERR(0, 944, __pyx_L1_error))
      if (unlikely(__pyx_v_tmp_bytes == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
        __PYX_ERR(0, 944, __pyx_L1_error)
      }
      __pyx_t_13 = __Pyx_PyBytes_AsString(__pyx_v_tmp_bytes); if (unlikely((!__pyx_t_13) && PyErr_Occurred())) __PYX_ERR(0, 944, __pyx_L1_error)
      (void)(fprintf(__pyx_v_self->bedGraph_ctrl_f, __pyx_t_13));

      /* "MACS2/IO/CallPeakUnit.pyx":939
 *                 logging.info ( "#3   Pileup will be based on sequencing depth in control." )
 * 
 *             if self.trackline:             # <<<<<<<<<<<<<<
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 */
    }

    /* "MACS2/IO/CallPeakUnit.pyx":924
 * 
 *         # prepare bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":946
 *                 fprintf( self.bedGraph_ctrl_f, tmp_bytes )
 * 
 *         logging.info("#3 Call peaks for each chromosome...")             # <<<<<<<<<<<<<<
 *         for chrom in self.chromosomes:
 *             # treat/control bedGraph will be saved if requested by user.
 */
  __Pyx_TraceLine(946,0,__PYX_ERR(0, 946, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 946, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 946, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_2, __pyx_kp_u_3_Call_peaks_for_each_chromosom) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_kp_u_3_Call_peaks_for_each_chromosom);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 946, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":947
 * 
 *         logging.info("#3 Call peaks for each chromosome...")
 *         for chrom in self.chromosomes:             # <<<<<<<<<<<<<<
 *             # treat/control bedGraph will be saved if requested by user.
 *             self.__chrom_call_peak_using_certain_criteria ( peaks, chrom, scoring_function_symbols, score_cutoff_s, min_length, max_gap, call_summits, self.save_bedGraph )
 */
  __Pyx_TraceLine(947,0,__PYX_ERR(0, 947, __pyx_L1_error))
  if (unlikely(__pyx_v_self->chromosomes == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
    __PYX_ERR(0, 947, __pyx_L1_error)
  }
  __pyx_t_1 = __pyx_v_self->chromosomes; __Pyx_INCREF(__pyx_t_1); __pyx_t_14 = 0;
  for (;;) {
    if (__pyx_t_14 >= PyList_GET_SIZE(__pyx_t_1)) break;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_5 = PyList_GET_ITEM(__pyx_t_1, __pyx_t_14); __Pyx_INCREF(__pyx_t_5); __pyx_t_14++; if (unlikely(0 < 0)) __PYX_ERR(0, 947, __pyx_L1_error)
    #else
    __pyx_t_5 = PySequence_ITEM(__pyx_t_1, __pyx_t_14); __pyx_t_14++; if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 947, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    #endif
    if (!(likely(PyBytes_CheckExact(__pyx_t_5))||((__pyx_t_5) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_5)->tp_name), 0))) __PYX_ERR(0, 947, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_chrom, ((PyObject*)__pyx_t_5));
    __pyx_t_5 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":949
 *         for chrom in self.chromosomes:
 *             # treat/control bedGraph will be saved if requested by user.
 *             self.__chrom_call_peak_using_certain_criteria ( peaks, chrom, scoring_function_symbols, score_cutoff_s, min_length, max_gap, call_summits, self.save_bedGraph )             # <<<<<<<<<<<<<<
 *             #print chrom, ":", ttime() - t0
 * 
 */
    __Pyx_TraceLine(949,0,__PYX_ERR(0, 949, __pyx_L1_error))
    __pyx_t_5 = ((PyObject *)__pyx_v_self->save_bedGraph);
    __Pyx_INCREF(__pyx_t_5);
    ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___chrom_call_peak_using_certain_criteria(__pyx_v_self, __pyx_v_peaks, __pyx_v_chrom, __pyx_v_scoring_function_symbols, __pyx_v_score_cutoff_s, __pyx_v_min_length, __pyx_v_max_gap, __pyx_v_call_summits, ((PyBoolObject *)__pyx_t_5));
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":947
 * 
 *         logging.info("#3 Call peaks for each chromosome...")
 *         for chrom in self.chromosomes:             # <<<<<<<<<<<<<<
 *             # treat/control bedGraph will be saved if requested by user.
 *             self.__chrom_call_peak_using_certain_criteria ( peaks, chrom, scoring_function_symbols, score_cutoff_s, min_length, max_gap, call_summits, self.save_bedGraph )
 */
    __Pyx_TraceLine(947,0,__PYX_ERR(0, 947, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":953
 * 
 *         # close bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 *             fclose(self.bedGraph_treat_f)
 *             fclose(self.bedGraph_ctrl_f)
 */
  __Pyx_TraceLine(953,0,__PYX_ERR(0, 953, __pyx_L1_error))
  __pyx_t_10 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->save_bedGraph)); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 953, __pyx_L1_error)
  if (__pyx_t_10) {

    /* "MACS2/IO/CallPeakUnit.pyx":954
 *         # close bedGraph file
 *         if self.save_bedGraph:
 *             fclose(self.bedGraph_treat_f)             # <<<<<<<<<<<<<<
 *             fclose(self.bedGraph_ctrl_f)
 *             self.save_bedGraph = False
 */
    __Pyx_TraceLine(954,0,__PYX_ERR(0, 954, __pyx_L1_error))
    (void)(fclose(__pyx_v_self->bedGraph_treat_f));

    /* "MACS2/IO/CallPeakUnit.pyx":955
 *         if self.save_bedGraph:
 *             fclose(self.bedGraph_treat_f)
 *             fclose(self.bedGraph_ctrl_f)             # <<<<<<<<<<<<<<
 *             self.save_bedGraph = False
 * 
 */
    __Pyx_TraceLine(955,0,__PYX_ERR(0, 955, __pyx_L1_error))
    (void)(fclose(__pyx_v_self->bedGraph_ctrl_f));

    /* "MACS2/IO/CallPeakUnit.pyx":956
 *             fclose(self.bedGraph_treat_f)
 *             fclose(self.bedGraph_ctrl_f)
 *             self.save_bedGraph = False             # <<<<<<<<<<<<<<
 * 
 *         #print "time to build peak regions: %f" % self.test_time
 */
    __Pyx_TraceLine(956,0,__PYX_ERR(0, 956, __pyx_L1_error))
    __Pyx_INCREF(Py_False);
    __Pyx_GIVEREF(Py_False);
    __Pyx_GOTREF(__pyx_v_self->save_bedGraph);
    __Pyx_DECREF(((PyObject *)__pyx_v_self->save_bedGraph));
    __pyx_v_self->save_bedGraph = ((PyBoolObject *)Py_False);

    /* "MACS2/IO/CallPeakUnit.pyx":953
 * 
 *         # close bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 *             fclose(self.bedGraph_treat_f)
 *             fclose(self.bedGraph_ctrl_f)
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":960
 *         #print "time to build peak regions: %f" % self.test_time
 * 
 *         return peaks             # <<<<<<<<<<<<<<
 * 
 *     cdef void __chrom_call_peak_using_certain_criteria ( self, peaks, bytes chrom, list scoring_function_s, list score_cutoff_s, int32_t min_length,
 */
  __Pyx_TraceLine(960,0,__PYX_ERR(0, 960, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_peaks);
  __pyx_r = __pyx_v_peaks;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":896
 *         return
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,             # <<<<<<<<<<<<<<
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.call_peaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_chrom);
  __Pyx_XDECREF(__pyx_v_tmp_bytes);
  __Pyx_XDECREF(__pyx_v_peaks);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_9call_peaks(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static char __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_8call_peaks[] = "Call peaks for all chromosomes. Return a PeakIO object.\n        \n        scoring_function_s: symbols of functions to calculate score. 'p' for pscore, 'q' for qscore, 'f' for fold change, 's' for subtraction. for example: ['p', 'q']\n        score_cutoff_s    : cutoff values corresponding to scoring functions\n        min_length        : minimum length of peak\n        max_gap           : maximum gap of 'insignificant' regions within a peak. Note, for PE_mode, max_gap and max_length are both set as fragment length.\n        call_summits      : boolean. Whether or not call sub-peaks.\n        save_bedGraph     : whether or not to save pileup and control into a bedGraph file\n        ";
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_9call_peaks(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_scoring_function_symbols = 0;
  PyObject *__pyx_v_score_cutoff_s = 0;
  __pyx_t_5numpy_int32_t __pyx_v_min_length;
  __pyx_t_5numpy_int32_t __pyx_v_max_gap;
  PyBoolObject *__pyx_v_call_summits = 0;
  PyBoolObject *__pyx_v_cutoff_analysis = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("call_peaks (wrapper)", 0);
  {
    static PyObject **__pyx_pyargnames[] = {&__pyx_n_s_scoring_function_symbols,&__pyx_n_s_score_cutoff_s,&__pyx_n_s_min_length,&__pyx_n_s_max_gap,&__pyx_n_s_call_summits,&__pyx_n_s_cutoff_analysis,0};
    PyObject* values[6] = {0,0,0,0,0,0};

    /* "MACS2/IO/CallPeakUnit.pyx":897
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):             # <<<<<<<<<<<<<<
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 * 
 */
    values[4] = (PyObject *)((PyBoolObject *)Py_False);
    values[5] = (PyObject *)((PyBoolObject *)Py_False);
    if (unlikely(__pyx_kwds)) {
      Py_ssize_t kw_args;
      const Py_ssize_t pos_args = PyTuple_GET_SIZE(__pyx_args);
      switch (pos_args) {
        case  6: values[5] = PyTuple_GET_ITEM(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = PyTuple_GET_ITEM(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = PyDict_Size(__pyx_kwds);
      switch (pos_args) {
        case  0:
        if (likely((values[0] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_scoring_function_symbols)) != 0)) kw_args--;
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_score_cutoff_s)) != 0)) kw_args--;
        else {
          __Pyx_RaiseArgtupleInvalid("call_peaks", 0, 2, 6, 1); __PYX_ERR(0, 896, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_min_length);
          if (value) { values[2] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  3:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_max_gap);
          if (value) { values[3] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  4:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_call_summits);
          if (value) { values[4] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  5:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_cutoff_analysis);
          if (value) { values[5] = value; kw_args--; }
        }
      }
      if (unlikely(kw_args > 0)) {
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_pyargnames, 0, values, pos_args, "call_peaks") < 0)) __PYX_ERR(0, 896, __pyx_L3_error)
      }
    } else {
      switch (PyTuple_GET_SIZE(__pyx_args)) {
        case  6: values[5] = PyTuple_GET_ITEM(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = PyTuple_GET_ITEM(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_scoring_function_symbols = ((PyObject*)values[0]);
    __pyx_v_score_cutoff_s = ((PyObject*)values[1]);
    if (values[2]) {
      __pyx_v_min_length = __Pyx_PyInt_As_npy_int32(values[2]); if (unlikely((__pyx_v_min_length == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 896, __pyx_L3_error)
    } else {
      __pyx_v_min_length = ((__pyx_t_5numpy_int32_t)0xC8);
    }
    if (values[3]) {
      __pyx_v_max_gap = __Pyx_PyInt_As_npy_int32(values[3]); if (unlikely((__pyx_v_max_gap == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 897, __pyx_L3_error)
    } else {
      __pyx_v_max_gap = ((__pyx_t_5numpy_int32_t)50);
    }
    __pyx_v_call_summits = ((PyBoolObject *)values[4]);
    __pyx_v_cutoff_analysis = ((PyBoolObject *)values[5]);
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("call_peaks", 0, 2, 6, PyTuple_GET_SIZE(__pyx_args)); __PYX_ERR(0, 896, __pyx_L3_error)
  __pyx_L3_error:;
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.call_peaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_scoring_function_symbols), (&PyList_Type), 1, "scoring_function_symbols", 1))) __PYX_ERR(0, 896, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_score_cutoff_s), (&PyList_Type), 1, "score_cutoff_s", 1))) __PYX_ERR(0, 896, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_call_summits), __pyx_ptype_7cpython_4bool_bool, 1, "call_summits", 0))) __PYX_ERR(0, 897, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_cutoff_analysis), __pyx_ptype_7cpython_4bool_bool, 1, "cutoff_analysis", 0))) __PYX_ERR(0, 897, __pyx_L1_error)
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_8call_peaks(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self), __pyx_v_scoring_function_symbols, __pyx_v_score_cutoff_s, __pyx_v_min_length, __pyx_v_max_gap, __pyx_v_call_summits, __pyx_v_cutoff_analysis);

  /* "MACS2/IO/CallPeakUnit.pyx":896
 *         return
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,             # <<<<<<<<<<<<<<
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_8call_peaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_score_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_max_gap, PyBoolObject *__pyx_v_call_summits, PyBoolObject *__pyx_v_cutoff_analysis) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks __pyx_t_2;
  __Pyx_RefNannySetupContext("call_peaks", 0);
  __Pyx_TraceCall("call_peaks (wrapper)", __pyx_f[0], 896, 0, __PYX_ERR(0, 896, __pyx_L1_error));
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_2.__pyx_n = 4;
  __pyx_t_2.min_length = __pyx_v_min_length;
  __pyx_t_2.max_gap = __pyx_v_max_gap;
  __pyx_t_2.call_summits = __pyx_v_call_summits;
  __pyx_t_2.cutoff_analysis = __pyx_v_cutoff_analysis;
  __pyx_t_1 = __pyx_vtabptr_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments->call_peaks(__pyx_v_self, __pyx_v_scoring_function_symbols, __pyx_v_score_cutoff_s, 1, &__pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 896, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.call_peaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":962
 *         return peaks
 * 
 *     cdef void __chrom_call_peak_using_certain_criteria ( self, peaks, bytes chrom, list scoring_function_s, list score_cutoff_s, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                                    int32_t max_gap, bool call_summits, bool save_bedGraph ):
 *         """ Call peaks for a chromosome.
 */

static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_call_peak_using_certain_criteria(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peaks, PyObject *__pyx_v_chrom, PyObject *__pyx_v_scoring_function_s, PyObject *__pyx_v_score_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_max_gap, PyBoolObject *__pyx_v_call_summits, PyBoolObject *__pyx_v_save_bedGraph) {
  __pyx_t_5numpy_int32_t __pyx_v_i;
  PyObject *__pyx_v_s = 0;
  PyArrayObject *__pyx_v_above_cutoff = 0;
  PyArrayObject *__pyx_v_above_cutoff_endpos = 0;
  PyArrayObject *__pyx_v_above_cutoff_startpos = 0;
  PyArrayObject *__pyx_v_pos_array = 0;
  PyArrayObject *__pyx_v_above_cutoff_index_array = 0;
  PyArrayObject *__pyx_v_treat_array = 0;
  PyArrayObject *__pyx_v_ctrl_array = 0;
  PyObject *__pyx_v_score_array_s = 0;
  PyObject *__pyx_v_peak_content = 0;
  __pyx_t_5numpy_int64_t __pyx_v_tl;
  __pyx_t_5numpy_int64_t __pyx_v_lastp;
  __pyx_t_5numpy_int64_t __pyx_v_ts;
  __pyx_t_5numpy_int64_t __pyx_v_te;
  __pyx_t_5numpy_int64_t __pyx_v_ti;
  __pyx_t_5numpy_float32_t __pyx_v_tp;
  __pyx_t_5numpy_float32_t __pyx_v_cp;
  __pyx_t_5numpy_int32_t *__pyx_v_acs_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_ace_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_acia_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_treat_array_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_ctrl_array_ptr;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_above_cutoff_endpos;
  __Pyx_Buffer __pyx_pybuffer_above_cutoff_endpos;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_above_cutoff_index_array;
  __Pyx_Buffer __pyx_pybuffer_above_cutoff_index_array;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_above_cutoff_startpos;
  __Pyx_Buffer __pyx_pybuffer_above_cutoff_startpos;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_ctrl_array;
  __Pyx_Buffer __pyx_pybuffer_ctrl_array;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_pos_array;
  __Pyx_Buffer __pyx_pybuffer_pos_array;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_treat_array;
  __Pyx_Buffer __pyx_pybuffer_treat_array;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  Py_ssize_t __pyx_t_1;
  Py_ssize_t __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyArrayObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  PyObject *__pyx_t_9 = NULL;
  PyObject *__pyx_t_10 = NULL;
  PyObject *__pyx_t_11 = NULL;
  PyArrayObject *__pyx_t_12 = NULL;
  int __pyx_t_13;
  __pyx_t_5numpy_int32_t __pyx_t_14;
  int __pyx_t_15;
  int __pyx_t_16;
  Py_ssize_t __pyx_t_17;
  PyObject *__pyx_t_18 = NULL;
  PyObject *__pyx_t_19 = NULL;
  npy_intp __pyx_t_20;
  npy_intp __pyx_t_21;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks __pyx_t_22;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks __pyx_t_23;
  __Pyx_RefNannySetupContext("__chrom_call_peak_using_certain_criteria", 0);
  __Pyx_TraceCall("__chrom_call_peak_using_certain_criteria", __pyx_f[0], 962, 0, __PYX_ERR(0, 962, __pyx_L1_error));
  __pyx_pybuffer_above_cutoff_endpos.pybuffer.buf = NULL;
  __pyx_pybuffer_above_cutoff_endpos.refcount = 0;
  __pyx_pybuffernd_above_cutoff_endpos.data = NULL;
  __pyx_pybuffernd_above_cutoff_endpos.rcbuffer = &__pyx_pybuffer_above_cutoff_endpos;
  __pyx_pybuffer_above_cutoff_startpos.pybuffer.buf = NULL;
  __pyx_pybuffer_above_cutoff_startpos.refcount = 0;
  __pyx_pybuffernd_above_cutoff_startpos.data = NULL;
  __pyx_pybuffernd_above_cutoff_startpos.rcbuffer = &__pyx_pybuffer_above_cutoff_startpos;
  __pyx_pybuffer_pos_array.pybuffer.buf = NULL;
  __pyx_pybuffer_pos_array.refcount = 0;
  __pyx_pybuffernd_pos_array.data = NULL;
  __pyx_pybuffernd_pos_array.rcbuffer = &__pyx_pybuffer_pos_array;
  __pyx_pybuffer_above_cutoff_index_array.pybuffer.buf = NULL;
  __pyx_pybuffer_above_cutoff_index_array.refcount = 0;
  __pyx_pybuffernd_above_cutoff_index_array.data = NULL;
  __pyx_pybuffernd_above_cutoff_index_array.rcbuffer = &__pyx_pybuffer_above_cutoff_index_array;
  __pyx_pybuffer_treat_array.pybuffer.buf = NULL;
  __pyx_pybuffer_treat_array.refcount = 0;
  __pyx_pybuffernd_treat_array.data = NULL;
  __pyx_pybuffernd_treat_array.rcbuffer = &__pyx_pybuffer_treat_array;
  __pyx_pybuffer_ctrl_array.pybuffer.buf = NULL;
  __pyx_pybuffer_ctrl_array.refcount = 0;
  __pyx_pybuffernd_ctrl_array.data = NULL;
  __pyx_pybuffernd_ctrl_array.rcbuffer = &__pyx_pybuffer_ctrl_array;

  /* "MACS2/IO/CallPeakUnit.pyx":998
 * 
 * 
 *         assert len(scoring_function_s) == len(score_cutoff_s), "number of functions and cutoffs should be the same!"             # <<<<<<<<<<<<<<
 * 
 *         peak_content = []           # to store points above cutoff
 */
  __Pyx_TraceLine(998,0,__PYX_ERR(0, 998, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(__pyx_v_scoring_function_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 998, __pyx_L1_error)
    }
    __pyx_t_1 = PyList_GET_SIZE(__pyx_v_scoring_function_s); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 998, __pyx_L1_error)
    if (unlikely(__pyx_v_score_cutoff_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 998, __pyx_L1_error)
    }
    __pyx_t_2 = PyList_GET_SIZE(__pyx_v_score_cutoff_s); if (unlikely(__pyx_t_2 == ((Py_ssize_t)-1))) __PYX_ERR(0, 998, __pyx_L1_error)
    if (unlikely(!((__pyx_t_1 == __pyx_t_2) != 0))) {
      PyErr_SetObject(PyExc_AssertionError, __pyx_kp_u_number_of_functions_and_cutoffs);
      __PYX_ERR(0, 998, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1000
 *         assert len(scoring_function_s) == len(score_cutoff_s), "number of functions and cutoffs should be the same!"
 * 
 *         peak_content = []           # to store points above cutoff             # <<<<<<<<<<<<<<
 * 
 *         # first, build pileup, self.chr_pos_treat_ctrl
 */
  __Pyx_TraceLine(1000,0,__PYX_ERR(0, 1000, __pyx_L1_error))
  __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1000, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_v_peak_content = ((PyObject*)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1004
 *         # first, build pileup, self.chr_pos_treat_ctrl
 *         # this step will be speeped up if pqtable is pre-computed.
 *         self.__pileup_treat_ctrl_a_chromosome( chrom )             # <<<<<<<<<<<<<<
 *         [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 * 
 */
  __Pyx_TraceLine(1004,0,__PYX_ERR(0, 1004, __pyx_L1_error))
  __pyx_t_3 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___pileup_treat_ctrl_a_chromosome(__pyx_v_self, __pyx_v_chrom); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1004, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1005
 *         # this step will be speeped up if pqtable is pre-computed.
 *         self.__pileup_treat_ctrl_a_chromosome( chrom )
 *         [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl             # <<<<<<<<<<<<<<
 * 
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 */
  __Pyx_TraceLine(1005,0,__PYX_ERR(0, 1005, __pyx_L1_error))
  __pyx_t_3 = __pyx_v_self->chr_pos_treat_ctrl;
  __Pyx_INCREF(__pyx_t_3);
  if (likely(__pyx_t_3 != Py_None)) {
    PyObject* sequence = __pyx_t_3;
    Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
    if (unlikely(size != 3)) {
      if (size > 3) __Pyx_RaiseTooManyValuesError(3);
      else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
      __PYX_ERR(0, 1005, __pyx_L1_error)
    }
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_4 = PyList_GET_ITEM(sequence, 0); 
    __pyx_t_5 = PyList_GET_ITEM(sequence, 1); 
    __pyx_t_6 = PyList_GET_ITEM(sequence, 2); 
    __Pyx_INCREF(__pyx_t_4);
    __Pyx_INCREF(__pyx_t_5);
    __Pyx_INCREF(__pyx_t_6);
    #else
    __pyx_t_4 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1005, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_5 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1005, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = PySequence_ITEM(sequence, 2); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1005, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    #endif
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else {
    __Pyx_RaiseNoneNotIterableError(); __PYX_ERR(0, 1005, __pyx_L1_error)
  }
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1005, __pyx_L1_error)
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1005, __pyx_L1_error)
  if (!(likely(((__pyx_t_6) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_6, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1005, __pyx_L1_error)
  __pyx_t_7 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer, (PyObject*)__pyx_t_7, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_10, &__pyx_t_11);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer, (PyObject*)__pyx_v_pos_array, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_11);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_10, __pyx_t_11);
      }
      __pyx_t_9 = __pyx_t_10 = __pyx_t_11 = 0;
    }
    __pyx_pybuffernd_pos_array.diminfo[0].strides = __pyx_pybuffernd_pos_array.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_pos_array.diminfo[0].shape = __pyx_pybuffernd_pos_array.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1005, __pyx_L1_error)
  }
  __pyx_t_7 = 0;
  __pyx_v_pos_array = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;
  __pyx_t_12 = ((PyArrayObject *)__pyx_t_5);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer, (PyObject*)__pyx_t_12, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_11, &__pyx_t_10, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer, (PyObject*)__pyx_v_treat_array, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_11); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_11, __pyx_t_10, __pyx_t_9);
      }
      __pyx_t_11 = __pyx_t_10 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_treat_array.diminfo[0].strides = __pyx_pybuffernd_treat_array.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_treat_array.diminfo[0].shape = __pyx_pybuffernd_treat_array.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1005, __pyx_L1_error)
  }
  __pyx_t_12 = 0;
  __pyx_v_treat_array = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;
  __pyx_t_12 = ((PyArrayObject *)__pyx_t_6);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer, (PyObject*)__pyx_t_12, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_10, &__pyx_t_11);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer, (PyObject*)__pyx_v_ctrl_array, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_11);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_10, __pyx_t_11);
      }
      __pyx_t_9 = __pyx_t_10 = __pyx_t_11 = 0;
    }
    __pyx_pybuffernd_ctrl_array.diminfo[0].strides = __pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_ctrl_array.diminfo[0].shape = __pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1005, __pyx_L1_error)
  }
  __pyx_t_12 = 0;
  __pyx_v_ctrl_array = ((PyArrayObject *)__pyx_t_6);
  __pyx_t_6 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1008
 * 
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 *         if save_bedGraph:             # <<<<<<<<<<<<<<
 *             self.__write_bedGraph_for_a_chromosome ( chrom )
 * 
 */
  __Pyx_TraceLine(1008,0,__PYX_ERR(0, 1008, __pyx_L1_error))
  __pyx_t_13 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_save_bedGraph)); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 1008, __pyx_L1_error)
  if (__pyx_t_13) {

    /* "MACS2/IO/CallPeakUnit.pyx":1009
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 *         if save_bedGraph:
 *             self.__write_bedGraph_for_a_chromosome ( chrom )             # <<<<<<<<<<<<<<
 * 
 *         # keep all types of scores needed
 */
    __Pyx_TraceLine(1009,0,__PYX_ERR(0, 1009, __pyx_L1_error))
    __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___write_bedGraph_for_a_chromosome(__pyx_v_self, __pyx_v_chrom)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1009, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1008
 * 
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 *         if save_bedGraph:             # <<<<<<<<<<<<<<
 *             self.__write_bedGraph_for_a_chromosome ( chrom )
 * 
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1013
 *         # keep all types of scores needed
 *         #t0 = ttime()
 *         score_array_s = []             # <<<<<<<<<<<<<<
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]
 */
  __Pyx_TraceLine(1013,0,__PYX_ERR(0, 1013, __pyx_L1_error))
  __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1013, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_v_score_array_s = ((PyObject*)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1014
 *         #t0 = ttime()
 *         score_array_s = []
 *         for i in range(len(scoring_function_s)):             # <<<<<<<<<<<<<<
 *             s = scoring_function_s[i]
 *             if s == 'p':
 */
  __Pyx_TraceLine(1014,0,__PYX_ERR(0, 1014, __pyx_L1_error))
  if (unlikely(__pyx_v_scoring_function_s == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 1014, __pyx_L1_error)
  }
  __pyx_t_2 = PyList_GET_SIZE(__pyx_v_scoring_function_s); if (unlikely(__pyx_t_2 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1014, __pyx_L1_error)
  __pyx_t_1 = __pyx_t_2;
  for (__pyx_t_14 = 0; __pyx_t_14 < __pyx_t_1; __pyx_t_14+=1) {
    __pyx_v_i = __pyx_t_14;

    /* "MACS2/IO/CallPeakUnit.pyx":1015
 *         score_array_s = []
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]             # <<<<<<<<<<<<<<
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 */
    __Pyx_TraceLine(1015,0,__PYX_ERR(0, 1015, __pyx_L1_error))
    if (unlikely(__pyx_v_scoring_function_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1015, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_scoring_function_s, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1015, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    if (!(likely(PyUnicode_CheckExact(__pyx_t_3))||((__pyx_t_3) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "unicode", Py_TYPE(__pyx_t_3)->tp_name), 0))) __PYX_ERR(0, 1015, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_s, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1016
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]
 *             if s == 'p':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':
 */
    __Pyx_TraceLine(1016,0,__PYX_ERR(0, 1016, __pyx_L1_error))
    __pyx_t_13 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_p, Py_EQ)); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 1016, __pyx_L1_error)
    __pyx_t_15 = (__pyx_t_13 != 0);
    if (__pyx_t_15) {

      /* "MACS2/IO/CallPeakUnit.pyx":1017
 *             s = scoring_function_s[i]
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 */
      __Pyx_TraceLine(1017,0,__PYX_ERR(0, 1017, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_pscore(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1017, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_16 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_16 == ((int)-1))) __PYX_ERR(0, 1017, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1016
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]
 *             if s == 'p':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1018
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':
 */
    __Pyx_TraceLine(1018,0,__PYX_ERR(0, 1018, __pyx_L1_error))
    __pyx_t_15 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_q, Py_EQ)); if (unlikely(__pyx_t_15 < 0)) __PYX_ERR(0, 1018, __pyx_L1_error)
    __pyx_t_13 = (__pyx_t_15 != 0);
    if (__pyx_t_13) {

      /* "MACS2/IO/CallPeakUnit.pyx":1019
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 */
      __Pyx_TraceLine(1019,0,__PYX_ERR(0, 1019, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_qscore(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1019, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_16 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_16 == ((int)-1))) __PYX_ERR(0, 1019, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1018
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1020
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':
 */
    __Pyx_TraceLine(1020,0,__PYX_ERR(0, 1020, __pyx_L1_error))
    __pyx_t_13 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_f, Py_EQ)); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 1020, __pyx_L1_error)
    __pyx_t_15 = (__pyx_t_13 != 0);
    if (__pyx_t_15) {

      /* "MACS2/IO/CallPeakUnit.pyx":1021
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 *             elif s == 's':
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )
 */
      __Pyx_TraceLine(1021,0,__PYX_ERR(0, 1021, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_FE(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1021, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_16 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_16 == ((int)-1))) __PYX_ERR(0, 1021, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1020
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1022
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )
 * 
 */
    __Pyx_TraceLine(1022,0,__PYX_ERR(0, 1022, __pyx_L1_error))
    __pyx_t_15 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_s, Py_EQ)); if (unlikely(__pyx_t_15 < 0)) __PYX_ERR(0, 1022, __pyx_L1_error)
    __pyx_t_13 = (__pyx_t_15 != 0);
    if (__pyx_t_13) {

      /* "MACS2/IO/CallPeakUnit.pyx":1023
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 * 
 *         #self.test_time += ttime() - t0
 */
      __Pyx_TraceLine(1023,0,__PYX_ERR(0, 1023, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_subtraction(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1023, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_16 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_16 == ((int)-1))) __PYX_ERR(0, 1023, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1022
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )
 * 
 */
    }
    __pyx_L6:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1030
 *         #t0 = ttime()
 *         # get the regions with scores above cutoffs
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,score_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?             # <<<<<<<<<<<<<<
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 */
  __Pyx_TraceLine(1030,0,__PYX_ERR(0, 1030, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_np); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1030, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_nonzero); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1030, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = ((PyObject *)__pyx_f_5MACS2_2IO_12CallPeakUnit_apply_multiple_cutoffs(__pyx_v_score_array_s, __pyx_v_score_cutoff_s)); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1030, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_4 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_3 = (__pyx_t_4) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_4, __pyx_t_6) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_6);
  __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1030, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_GetItemInt(__pyx_t_3, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1030, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1030, __pyx_L1_error)
  __pyx_v_above_cutoff = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1031
 *         # get the regions with scores above cutoffs
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,score_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices             # <<<<<<<<<<<<<<
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 */
  __Pyx_TraceLine(1031,0,__PYX_ERR(0, 1031, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_np); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1031, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_arange); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1031, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_pos_array->dimensions[0])); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1031, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = PyTuple_New(1); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1031, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_GIVEREF(__pyx_t_5);
  PyTuple_SET_ITEM(__pyx_t_6, 0, __pyx_t_5);
  __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1031, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  if (PyDict_SetItem(__pyx_t_5, __pyx_n_s_dtype, __pyx_n_u_int32) < 0) __PYX_ERR(0, 1031, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_3, __pyx_t_6, __pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1031, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_PyObject_GetItem(__pyx_t_4, ((PyObject *)__pyx_v_above_cutoff)); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1031, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1031, __pyx_L1_error)
  __pyx_t_7 = ((PyArrayObject *)__pyx_t_5);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_index_array.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_above_cutoff_index_array.rcbuffer->pybuffer, (PyObject*)__pyx_t_7, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_11, &__pyx_t_10, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_above_cutoff_index_array.rcbuffer->pybuffer, (PyObject*)__pyx_v_above_cutoff_index_array, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_11); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_11, __pyx_t_10, __pyx_t_9);
      }
      __pyx_t_11 = __pyx_t_10 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_above_cutoff_index_array.diminfo[0].strides = __pyx_pybuffernd_above_cutoff_index_array.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_above_cutoff_index_array.diminfo[0].shape = __pyx_pybuffernd_above_cutoff_index_array.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1031, __pyx_L1_error)
  }
  __pyx_t_7 = 0;
  __pyx_v_above_cutoff_index_array = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1032
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,score_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 */
  __Pyx_TraceLine(1032,0,__PYX_ERR(0, 1032, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), ((PyObject *)__pyx_v_above_cutoff)); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1032, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1032, __pyx_L1_error)
  __pyx_t_7 = ((PyArrayObject *)__pyx_t_5);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_endpos.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_above_cutoff_endpos.rcbuffer->pybuffer, (PyObject*)__pyx_t_7, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_10, &__pyx_t_11);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_above_cutoff_endpos.rcbuffer->pybuffer, (PyObject*)__pyx_v_above_cutoff_endpos, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_11);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_10, __pyx_t_11);
      }
      __pyx_t_9 = __pyx_t_10 = __pyx_t_11 = 0;
    }
    __pyx_pybuffernd_above_cutoff_endpos.diminfo[0].strides = __pyx_pybuffernd_above_cutoff_endpos.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_above_cutoff_endpos.diminfo[0].shape = __pyx_pybuffernd_above_cutoff_endpos.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1032, __pyx_L1_error)
  }
  __pyx_t_7 = 0;
  __pyx_v_above_cutoff_endpos = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1033
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 * 
 *         if above_cutoff.size == 0:
 */
  __Pyx_TraceLine(1033,0,__PYX_ERR(0, 1033, __pyx_L1_error))
  __pyx_t_5 = PyNumber_Subtract(((PyObject *)__pyx_v_above_cutoff), __pyx_int_1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1033, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_4 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), __pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1033, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1033, __pyx_L1_error)
  __pyx_t_7 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer, (PyObject*)__pyx_t_7, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES| PyBUF_WRITABLE, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_11, &__pyx_t_10, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer, (PyObject*)__pyx_v_above_cutoff_startpos, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES| PyBUF_WRITABLE, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_11); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_11, __pyx_t_10, __pyx_t_9);
      }
      __pyx_t_11 = __pyx_t_10 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_above_cutoff_startpos.diminfo[0].strides = __pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_above_cutoff_startpos.diminfo[0].shape = __pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1033, __pyx_L1_error)
  }
  __pyx_t_7 = 0;
  __pyx_v_above_cutoff_startpos = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1035
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *         if above_cutoff.size == 0:             # <<<<<<<<<<<<<<
 *             # nothing above cutoff
 *             return
 */
  __Pyx_TraceLine(1035,0,__PYX_ERR(0, 1035, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_above_cutoff), __pyx_n_s_size); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1035, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_5 = __Pyx_PyInt_EqObjC(__pyx_t_4, __pyx_int_0, 0, 0); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1035, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_13 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 1035, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (__pyx_t_13) {

    /* "MACS2/IO/CallPeakUnit.pyx":1037
 *         if above_cutoff.size == 0:
 *             # nothing above cutoff
 *             return             # <<<<<<<<<<<<<<
 * 
 *         if above_cutoff[0] == 0:
 */
    __Pyx_TraceLine(1037,0,__PYX_ERR(0, 1037, __pyx_L1_error))
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1035
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *         if above_cutoff.size == 0:             # <<<<<<<<<<<<<<
 *             # nothing above cutoff
 *             return
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1039
 *             return
 * 
 *         if above_cutoff[0] == 0:             # <<<<<<<<<<<<<<
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0
 */
  __Pyx_TraceLine(1039,0,__PYX_ERR(0, 1039, __pyx_L1_error))
  __pyx_t_5 = __Pyx_GetItemInt(((PyObject *)__pyx_v_above_cutoff), 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1039, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_4 = __Pyx_PyInt_EqObjC(__pyx_t_5, __pyx_int_0, 0, 0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1039, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_13 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 1039, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (__pyx_t_13) {

    /* "MACS2/IO/CallPeakUnit.pyx":1041
 *         if above_cutoff[0] == 0:
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0             # <<<<<<<<<<<<<<
 * 
 *         #print "apply cutoff -- chrom:",chrom,"  time:", ttime() - t0
 */
    __Pyx_TraceLine(1041,0,__PYX_ERR(0, 1041, __pyx_L1_error))
    __pyx_t_17 = 0;
    __pyx_t_8 = -1;
    if (__pyx_t_17 < 0) {
      __pyx_t_17 += __pyx_pybuffernd_above_cutoff_startpos.diminfo[0].shape;
      if (unlikely(__pyx_t_17 < 0)) __pyx_t_8 = 0;
    } else if (unlikely(__pyx_t_17 >= __pyx_pybuffernd_above_cutoff_startpos.diminfo[0].shape)) __pyx_t_8 = 0;
    if (unlikely(__pyx_t_8 != -1)) {
      __Pyx_RaiseBufferIndexError(__pyx_t_8);
      __PYX_ERR(0, 1041, __pyx_L1_error)
    }
    *__Pyx_BufPtrStrided1d(__pyx_t_5numpy_int32_t *, __pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer.buf, __pyx_t_17, __pyx_pybuffernd_above_cutoff_startpos.diminfo[0].strides) = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1039
 *             return
 * 
 *         if above_cutoff[0] == 0:             # <<<<<<<<<<<<<<
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1048
 * 
 *         # first bit of region above cutoff
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data             # <<<<<<<<<<<<<<
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 */
  __Pyx_TraceLine(1048,0,__PYX_ERR(0, 1048, __pyx_L1_error))
  __pyx_v_acs_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_startpos->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1049
 *         # first bit of region above cutoff
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data             # <<<<<<<<<<<<<<
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 */
  __Pyx_TraceLine(1049,0,__PYX_ERR(0, 1049, __pyx_L1_error))
  __pyx_v_ace_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_endpos->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1050
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data             # <<<<<<<<<<<<<<
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 */
  __Pyx_TraceLine(1050,0,__PYX_ERR(0, 1050, __pyx_L1_error))
  __pyx_v_acia_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_index_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1051
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data             # <<<<<<<<<<<<<<
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 */
  __Pyx_TraceLine(1051,0,__PYX_ERR(0, 1051, __pyx_L1_error))
  __pyx_v_treat_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_treat_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1052
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data             # <<<<<<<<<<<<<<
 * 
 *         ts = acs_ptr[ 0 ]
 */
  __Pyx_TraceLine(1052,0,__PYX_ERR(0, 1052, __pyx_L1_error))
  __pyx_v_ctrl_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_ctrl_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1054
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 *         ts = acs_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]
 */
  __Pyx_TraceLine(1054,0,__PYX_ERR(0, 1054, __pyx_L1_error))
  __pyx_v_ts = (__pyx_v_acs_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1055
 * 
 *         ts = acs_ptr[ 0 ]
 *         te = ace_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]
 */
  __Pyx_TraceLine(1055,0,__PYX_ERR(0, 1055, __pyx_L1_error))
  __pyx_v_te = (__pyx_v_ace_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1056
 *         ts = acs_ptr[ 0 ]
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         tp = treat_array_ptr[ ti ]
 *         cp = ctrl_array_ptr[ ti ]
 */
  __Pyx_TraceLine(1056,0,__PYX_ERR(0, 1056, __pyx_L1_error))
  __pyx_v_ti = (__pyx_v_acia_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1057
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *         cp = ctrl_array_ptr[ ti ]
 * 
 */
  __Pyx_TraceLine(1057,0,__PYX_ERR(0, 1057, __pyx_L1_error))
  __pyx_v_tp = (__pyx_v_treat_array_ptr[__pyx_v_ti]);

  /* "MACS2/IO/CallPeakUnit.pyx":1058
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]
 *         cp = ctrl_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 * 
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 */
  __Pyx_TraceLine(1058,0,__PYX_ERR(0, 1058, __pyx_L1_error))
  __pyx_v_cp = (__pyx_v_ctrl_array_ptr[__pyx_v_ti]);

  /* "MACS2/IO/CallPeakUnit.pyx":1060
 *         cp = ctrl_array_ptr[ ti ]
 * 
 *         peak_content.append( ( ts, te, tp, cp, ti ) )             # <<<<<<<<<<<<<<
 *         lastp = te
 *         acs_ptr += 1
 */
  __Pyx_TraceLine(1060,0,__PYX_ERR(0, 1060, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyInt_From_npy_int64(__pyx_v_ts); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1060, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_5 = __Pyx_PyInt_From_npy_int64(__pyx_v_te); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1060, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = PyFloat_FromDouble(__pyx_v_tp); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1060, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_3 = PyFloat_FromDouble(__pyx_v_cp); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1060, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_18 = __Pyx_PyInt_From_npy_int64(__pyx_v_ti); if (unlikely(!__pyx_t_18)) __PYX_ERR(0, 1060, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_18);
  __pyx_t_19 = PyTuple_New(5); if (unlikely(!__pyx_t_19)) __PYX_ERR(0, 1060, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_19);
  __Pyx_GIVEREF(__pyx_t_4);
  PyTuple_SET_ITEM(__pyx_t_19, 0, __pyx_t_4);
  __Pyx_GIVEREF(__pyx_t_5);
  PyTuple_SET_ITEM(__pyx_t_19, 1, __pyx_t_5);
  __Pyx_GIVEREF(__pyx_t_6);
  PyTuple_SET_ITEM(__pyx_t_19, 2, __pyx_t_6);
  __Pyx_GIVEREF(__pyx_t_3);
  PyTuple_SET_ITEM(__pyx_t_19, 3, __pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_18);
  PyTuple_SET_ITEM(__pyx_t_19, 4, __pyx_t_18);
  __pyx_t_4 = 0;
  __pyx_t_5 = 0;
  __pyx_t_6 = 0;
  __pyx_t_3 = 0;
  __pyx_t_18 = 0;
  __pyx_t_16 = __Pyx_PyList_Append(__pyx_v_peak_content, __pyx_t_19); if (unlikely(__pyx_t_16 == ((int)-1))) __PYX_ERR(0, 1060, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_19); __pyx_t_19 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1061
 * 
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 *         lastp = te             # <<<<<<<<<<<<<<
 *         acs_ptr += 1
 *         ace_ptr += 1
 */
  __Pyx_TraceLine(1061,0,__PYX_ERR(0, 1061, __pyx_L1_error))
  __pyx_v_lastp = __pyx_v_te;

  /* "MACS2/IO/CallPeakUnit.pyx":1062
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 *         lastp = te
 *         acs_ptr += 1             # <<<<<<<<<<<<<<
 *         ace_ptr += 1
 *         acia_ptr+= 1
 */
  __Pyx_TraceLine(1062,0,__PYX_ERR(0, 1062, __pyx_L1_error))
  __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1063
 *         lastp = te
 *         acs_ptr += 1
 *         ace_ptr += 1             # <<<<<<<<<<<<<<
 *         acia_ptr+= 1
 * 
 */
  __Pyx_TraceLine(1063,0,__PYX_ERR(0, 1063, __pyx_L1_error))
  __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1064
 *         acs_ptr += 1
 *         ace_ptr += 1
 *         acia_ptr+= 1             # <<<<<<<<<<<<<<
 * 
 *         for i in range( 1, above_cutoff_startpos.shape[0] ):
 */
  __Pyx_TraceLine(1064,0,__PYX_ERR(0, 1064, __pyx_L1_error))
  __pyx_v_acia_ptr = (__pyx_v_acia_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1066
 *         acia_ptr+= 1
 * 
 *         for i in range( 1, above_cutoff_startpos.shape[0] ):             # <<<<<<<<<<<<<<
 *             ts = acs_ptr[ 0 ]
 *             te = ace_ptr[ 0 ]
 */
  __Pyx_TraceLine(1066,0,__PYX_ERR(0, 1066, __pyx_L1_error))
  __pyx_t_20 = (__pyx_v_above_cutoff_startpos->dimensions[0]);
  __pyx_t_21 = __pyx_t_20;
  for (__pyx_t_14 = 1; __pyx_t_14 < __pyx_t_21; __pyx_t_14+=1) {
    __pyx_v_i = __pyx_t_14;

    /* "MACS2/IO/CallPeakUnit.pyx":1067
 * 
 *         for i in range( 1, above_cutoff_startpos.shape[0] ):
 *             ts = acs_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *             te = ace_ptr[ 0 ]
 *             ti = acia_ptr[ 0 ]
 */
    __Pyx_TraceLine(1067,0,__PYX_ERR(0, 1067, __pyx_L1_error))
    __pyx_v_ts = (__pyx_v_acs_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1068
 *         for i in range( 1, above_cutoff_startpos.shape[0] ):
 *             ts = acs_ptr[ 0 ]
 *             te = ace_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *             ti = acia_ptr[ 0 ]
 *             acs_ptr += 1
 */
    __Pyx_TraceLine(1068,0,__PYX_ERR(0, 1068, __pyx_L1_error))
    __pyx_v_te = (__pyx_v_ace_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1069
 *             ts = acs_ptr[ 0 ]
 *             te = ace_ptr[ 0 ]
 *             ti = acia_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *             acs_ptr += 1
 *             ace_ptr += 1
 */
    __Pyx_TraceLine(1069,0,__PYX_ERR(0, 1069, __pyx_L1_error))
    __pyx_v_ti = (__pyx_v_acia_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1070
 *             te = ace_ptr[ 0 ]
 *             ti = acia_ptr[ 0 ]
 *             acs_ptr += 1             # <<<<<<<<<<<<<<
 *             ace_ptr += 1
 *             acia_ptr+= 1
 */
    __Pyx_TraceLine(1070,0,__PYX_ERR(0, 1070, __pyx_L1_error))
    __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1071
 *             ti = acia_ptr[ 0 ]
 *             acs_ptr += 1
 *             ace_ptr += 1             # <<<<<<<<<<<<<<
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ]
 */
    __Pyx_TraceLine(1071,0,__PYX_ERR(0, 1071, __pyx_L1_error))
    __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1072
 *             acs_ptr += 1
 *             ace_ptr += 1
 *             acia_ptr+= 1             # <<<<<<<<<<<<<<
 *             tp = treat_array_ptr[ ti ]
 *             cp = ctrl_array_ptr[ ti ]
 */
    __Pyx_TraceLine(1072,0,__PYX_ERR(0, 1072, __pyx_L1_error))
    __pyx_v_acia_ptr = (__pyx_v_acia_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1073
 *             ace_ptr += 1
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp
 */
    __Pyx_TraceLine(1073,0,__PYX_ERR(0, 1073, __pyx_L1_error))
    __pyx_v_tp = (__pyx_v_treat_array_ptr[__pyx_v_ti]);

    /* "MACS2/IO/CallPeakUnit.pyx":1074
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ]
 *             cp = ctrl_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *             tl = ts - lastp
 *             if tl <= max_gap:
 */
    __Pyx_TraceLine(1074,0,__PYX_ERR(0, 1074, __pyx_L1_error))
    __pyx_v_cp = (__pyx_v_ctrl_array_ptr[__pyx_v_ti]);

    /* "MACS2/IO/CallPeakUnit.pyx":1075
 *             tp = treat_array_ptr[ ti ]
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp             # <<<<<<<<<<<<<<
 *             if tl <= max_gap:
 *                 # append.
 */
    __Pyx_TraceLine(1075,0,__PYX_ERR(0, 1075, __pyx_L1_error))
    __pyx_v_tl = (__pyx_v_ts - __pyx_v_lastp);

    /* "MACS2/IO/CallPeakUnit.pyx":1076
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp
 *             if tl <= max_gap:             # <<<<<<<<<<<<<<
 *                 # append.
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )
 */
    __Pyx_TraceLine(1076,0,__PYX_ERR(0, 1076, __pyx_L1_error))
    __pyx_t_13 = ((__pyx_v_tl <= __pyx_v_max_gap) != 0);
    if (__pyx_t_13) {

      /* "MACS2/IO/CallPeakUnit.pyx":1078
 *             if tl <= max_gap:
 *                 # append.
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )             # <<<<<<<<<<<<<<
 *                 lastp = te #above_cutoff_endpos[i]
 *             else:
 */
      __Pyx_TraceLine(1078,0,__PYX_ERR(0, 1078, __pyx_L1_error))
      __pyx_t_19 = __Pyx_PyInt_From_npy_int64(__pyx_v_ts); if (unlikely(!__pyx_t_19)) __PYX_ERR(0, 1078, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_19);
      __pyx_t_18 = __Pyx_PyInt_From_npy_int64(__pyx_v_te); if (unlikely(!__pyx_t_18)) __PYX_ERR(0, 1078, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_18);
      __pyx_t_3 = PyFloat_FromDouble(__pyx_v_tp); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1078, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_6 = PyFloat_FromDouble(__pyx_v_cp); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1078, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __pyx_t_5 = __Pyx_PyInt_From_npy_int64(__pyx_v_ti); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1078, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_4 = PyTuple_New(5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1078, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_GIVEREF(__pyx_t_19);
      PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_t_19);
      __Pyx_GIVEREF(__pyx_t_18);
      PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_18);
      __Pyx_GIVEREF(__pyx_t_3);
      PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_t_3);
      __Pyx_GIVEREF(__pyx_t_6);
      PyTuple_SET_ITEM(__pyx_t_4, 3, __pyx_t_6);
      __Pyx_GIVEREF(__pyx_t_5);
      PyTuple_SET_ITEM(__pyx_t_4, 4, __pyx_t_5);
      __pyx_t_19 = 0;
      __pyx_t_18 = 0;
      __pyx_t_3 = 0;
      __pyx_t_6 = 0;
      __pyx_t_5 = 0;
      __pyx_t_16 = __Pyx_PyList_Append(__pyx_v_peak_content, __pyx_t_4); if (unlikely(__pyx_t_16 == ((int)-1))) __PYX_ERR(0, 1078, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1079
 *                 # append.
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )
 *                 lastp = te #above_cutoff_endpos[i]             # <<<<<<<<<<<<<<
 *             else:
 *                 # close
 */
      __Pyx_TraceLine(1079,0,__PYX_ERR(0, 1079, __pyx_L1_error))
      __pyx_v_lastp = __pyx_v_te;

      /* "MACS2/IO/CallPeakUnit.pyx":1076
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp
 *             if tl <= max_gap:             # <<<<<<<<<<<<<<
 *                 # append.
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )
 */
      goto __pyx_L11;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1082
 *             else:
 *                 # close
 *                 if call_summits:             # <<<<<<<<<<<<<<
 *                     self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *                 else:
 */
    __Pyx_TraceLine(1082,0,__PYX_ERR(0, 1082, __pyx_L1_error))
    /*else*/ {
      __pyx_t_13 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_call_summits)); if (unlikely(__pyx_t_13 < 0)) __PYX_ERR(0, 1082, __pyx_L1_error)
      if (__pyx_t_13) {

        /* "MACS2/IO/CallPeakUnit.pyx":1083
 *                 # close
 *                 if call_summits:
 *                     self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'             # <<<<<<<<<<<<<<
 *                 else:
 *                     self.__close_peak_wo_subpeaks   (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 */
        __Pyx_TraceLine(1083,0,__PYX_ERR(0, 1083, __pyx_L1_error))
        __pyx_t_22.__pyx_n = 1;
        __pyx_t_22.score_cutoff_s = __pyx_v_score_cutoff_s;
        __pyx_t_4 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_with_subpeaks(__pyx_v_self, __pyx_v_peak_content, __pyx_v_peaks, __pyx_v_min_length, __pyx_v_chrom, __pyx_v_min_length, __pyx_v_score_array_s, &__pyx_t_22)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1083, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1082
 *             else:
 *                 # close
 *                 if call_summits:             # <<<<<<<<<<<<<<
 *                     self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *                 else:
 */
        goto __pyx_L12;
      }

      /* "MACS2/IO/CallPeakUnit.pyx":1085
 *                     self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *                 else:
 *                     self.__close_peak_wo_subpeaks   (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'             # <<<<<<<<<<<<<<
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]
 *                 lastp = te #above_cutoff_endpos[i]
 */
      __Pyx_TraceLine(1085,0,__PYX_ERR(0, 1085, __pyx_L1_error))
      /*else*/ {
        __pyx_t_23.__pyx_n = 1;
        __pyx_t_23.score_cutoff_s = __pyx_v_score_cutoff_s;
        __pyx_t_4 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_wo_subpeaks(__pyx_v_self, __pyx_v_peak_content, __pyx_v_peaks, __pyx_v_min_length, __pyx_v_chrom, __pyx_v_min_length, __pyx_v_score_array_s, &__pyx_t_23)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1085, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      }
      __pyx_L12:;

      /* "MACS2/IO/CallPeakUnit.pyx":1086
 *                 else:
 *                     self.__close_peak_wo_subpeaks   (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]             # <<<<<<<<<<<<<<
 *                 lastp = te #above_cutoff_endpos[i]
 *         # save the last peak
 */
      __Pyx_TraceLine(1086,0,__PYX_ERR(0, 1086, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_npy_int64(__pyx_v_ts); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1086, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_5 = __Pyx_PyInt_From_npy_int64(__pyx_v_te); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1086, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_6 = PyFloat_FromDouble(__pyx_v_tp); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1086, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __pyx_t_3 = PyFloat_FromDouble(__pyx_v_cp); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1086, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_18 = __Pyx_PyInt_From_npy_int64(__pyx_v_ti); if (unlikely(!__pyx_t_18)) __PYX_ERR(0, 1086, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_18);
      __pyx_t_19 = PyTuple_New(5); if (unlikely(!__pyx_t_19)) __PYX_ERR(0, 1086, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_19);
      __Pyx_GIVEREF(__pyx_t_4);
      PyTuple_SET_ITEM(__pyx_t_19, 0, __pyx_t_4);
      __Pyx_GIVEREF(__pyx_t_5);
      PyTuple_SET_ITEM(__pyx_t_19, 1, __pyx_t_5);
      __Pyx_GIVEREF(__pyx_t_6);
      PyTuple_SET_ITEM(__pyx_t_19, 2, __pyx_t_6);
      __Pyx_GIVEREF(__pyx_t_3);
      PyTuple_SET_ITEM(__pyx_t_19, 3, __pyx_t_3);
      __Pyx_GIVEREF(__pyx_t_18);
      PyTuple_SET_ITEM(__pyx_t_19, 4, __pyx_t_18);
      __pyx_t_4 = 0;
      __pyx_t_5 = 0;
      __pyx_t_6 = 0;
      __pyx_t_3 = 0;
      __pyx_t_18 = 0;
      __pyx_t_18 = PyList_New(1); if (unlikely(!__pyx_t_18)) __PYX_ERR(0, 1086, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_18);
      __Pyx_GIVEREF(__pyx_t_19);
      PyList_SET_ITEM(__pyx_t_18, 0, __pyx_t_19);
      __pyx_t_19 = 0;
      __Pyx_DECREF_SET(__pyx_v_peak_content, ((PyObject*)__pyx_t_18));
      __pyx_t_18 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1087
 *                     self.__close_peak_wo_subpeaks   (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]
 *                 lastp = te #above_cutoff_endpos[i]             # <<<<<<<<<<<<<<
 *         # save the last peak
 *         if not peak_content:
 */
      __Pyx_TraceLine(1087,0,__PYX_ERR(0, 1087, __pyx_L1_error))
      __pyx_v_lastp = __pyx_v_te;
    }
    __pyx_L11:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1089
 *                 lastp = te #above_cutoff_endpos[i]
 *         # save the last peak
 *         if not peak_content:             # <<<<<<<<<<<<<<
 *             return
 *         else:
 */
  __Pyx_TraceLine(1089,0,__PYX_ERR(0, 1089, __pyx_L1_error))
  __pyx_t_13 = (PyList_GET_SIZE(__pyx_v_peak_content) != 0);
  __pyx_t_15 = ((!__pyx_t_13) != 0);
  if (__pyx_t_15) {

    /* "MACS2/IO/CallPeakUnit.pyx":1090
 *         # save the last peak
 *         if not peak_content:
 *             return             # <<<<<<<<<<<<<<
 *         else:
 *             if call_summits:
 */
    __Pyx_TraceLine(1090,0,__PYX_ERR(0, 1090, __pyx_L1_error))
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1089
 *                 lastp = te #above_cutoff_endpos[i]
 *         # save the last peak
 *         if not peak_content:             # <<<<<<<<<<<<<<
 *             return
 *         else:
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1092
 *             return
 *         else:
 *             if call_summits:             # <<<<<<<<<<<<<<
 *                 self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *             else:
 */
  __Pyx_TraceLine(1092,0,__PYX_ERR(0, 1092, __pyx_L1_error))
  /*else*/ {
    __pyx_t_15 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_call_summits)); if (unlikely(__pyx_t_15 < 0)) __PYX_ERR(0, 1092, __pyx_L1_error)
    if (__pyx_t_15) {

      /* "MACS2/IO/CallPeakUnit.pyx":1093
 *         else:
 *             if call_summits:
 *                 self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'             # <<<<<<<<<<<<<<
 *             else:
 *                 self.__close_peak_wo_subpeaks   (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 */
      __Pyx_TraceLine(1093,0,__PYX_ERR(0, 1093, __pyx_L1_error))
      __pyx_t_22.__pyx_n = 1;
      __pyx_t_22.score_cutoff_s = __pyx_v_score_cutoff_s;
      __pyx_t_18 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_with_subpeaks(__pyx_v_self, __pyx_v_peak_content, __pyx_v_peaks, __pyx_v_min_length, __pyx_v_chrom, __pyx_v_min_length, __pyx_v_score_array_s, &__pyx_t_22)); if (unlikely(!__pyx_t_18)) __PYX_ERR(0, 1093, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_18);
      __Pyx_DECREF(__pyx_t_18); __pyx_t_18 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1092
 *             return
 *         else:
 *             if call_summits:             # <<<<<<<<<<<<<<
 *                 self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *             else:
 */
      goto __pyx_L14;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1095
 *                 self.__close_peak_with_subpeaks (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'
 *             else:
 *                 self.__close_peak_wo_subpeaks   (peak_content, peaks, min_length, chrom, min_length, score_array_s, score_cutoff_s = score_cutoff_s ) # smooth length is min_length, i.e. fragment size 'd'             # <<<<<<<<<<<<<<
 * 
 *         #print "close peaks -- chrom:",chrom,"  time:", ttime() - t0
 */
    __Pyx_TraceLine(1095,0,__PYX_ERR(0, 1095, __pyx_L1_error))
    /*else*/ {
      __pyx_t_23.__pyx_n = 1;
      __pyx_t_23.score_cutoff_s = __pyx_v_score_cutoff_s;
      __pyx_t_18 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_wo_subpeaks(__pyx_v_self, __pyx_v_peak_content, __pyx_v_peaks, __pyx_v_min_length, __pyx_v_chrom, __pyx_v_min_length, __pyx_v_score_array_s, &__pyx_t_23)); if (unlikely(!__pyx_t_18)) __PYX_ERR(0, 1095, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_18);
      __Pyx_DECREF(__pyx_t_18); __pyx_t_18 = 0;
    }
    __pyx_L14:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1098
 * 
 *         #print "close peaks -- chrom:",chrom,"  time:", ttime() - t0
 *         return             # <<<<<<<<<<<<<<
 * 
 *     cdef bool __close_peak_wo_subpeaks (self, list peak_content, peaks, int32_t min_length,
 */
  __Pyx_TraceLine(1098,0,__PYX_ERR(0, 1098, __pyx_L1_error))
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":962
 *         return peaks
 * 
 *     cdef void __chrom_call_peak_using_certain_criteria ( self, peaks, bytes chrom, list scoring_function_s, list score_cutoff_s, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                                    int32_t max_gap, bool call_summits, bool save_bedGraph ):
 *         """ Call peaks for a chromosome.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_18);
  __Pyx_XDECREF(__pyx_t_19);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_endpos.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_index_array.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.CallerFromAlignments.__chrom_call_peak_using_certain_criteria", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_endpos.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_index_array.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_above_cutoff_startpos.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF(__pyx_v_s);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_endpos);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_startpos);
  __Pyx_XDECREF((PyObject *)__pyx_v_pos_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_index_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_treat_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_ctrl_array);
  __Pyx_XDECREF(__pyx_v_score_array_s);
  __Pyx_XDECREF(__pyx_v_peak_content);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "MACS2/IO/CallPeakUnit.pyx":1100
 *         return
 * 
 *     cdef bool __close_peak_wo_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                           bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the peak region, output peak boundaries, peak summit
 */

static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peak_content, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_min_length, PyObject *__pyx_v_chrom, CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_smoothlen, PyObject *__pyx_v_score_array_s, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks *__pyx_optional_args) {
  PyObject *__pyx_v_score_cutoff_s = __pyx_k__11;
  __pyx_t_5numpy_int32_t __pyx_v_summit_pos;
  __pyx_t_5numpy_int32_t __pyx_v_tstart;
  __pyx_t_5numpy_int32_t __pyx_v_tend;
  __pyx_t_5numpy_int32_t __pyx_v_summit_index;
  __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_int32_t __pyx_v_midindex;
  __pyx_t_5numpy_float64_t __pyx_v_ttreat_p;
  CYTHON_UNUSED __pyx_t_5numpy_float64_t __pyx_v_tctrl_p;
  __pyx_t_5numpy_float64_t __pyx_v_tscore;
  __pyx_t_5numpy_float64_t __pyx_v_summit_treat;
  __pyx_t_5numpy_float64_t __pyx_v_summit_ctrl;
  __pyx_t_5numpy_float64_t __pyx_v_summit_p_score;
  __pyx_t_5numpy_float64_t __pyx_v_summit_q_score;
  CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_tlist_scores_p;
  PyObject *__pyx_v_peak_length = NULL;
  PyObject *__pyx_v_tsummit = NULL;
  PyObject *__pyx_v_summit_value = NULL;
  PyObject *__pyx_v_tsummit_index = NULL;
  PyBoolObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  Py_ssize_t __pyx_t_5;
  Py_ssize_t __pyx_t_6;
  __pyx_t_5numpy_int32_t __pyx_t_7;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  PyObject *__pyx_t_10 = NULL;
  PyObject *__pyx_t_11 = NULL;
  PyObject *(*__pyx_t_12)(PyObject *);
  __pyx_t_5numpy_int32_t __pyx_t_13;
  __pyx_t_5numpy_int32_t __pyx_t_14;
  __pyx_t_5numpy_float64_t __pyx_t_15;
  __pyx_t_5numpy_float64_t __pyx_t_16;
  __pyx_t_5numpy_int32_t __pyx_t_17;
  int __pyx_t_18;
  int __pyx_t_19;
  int __pyx_t_20;
  __Pyx_RefNannySetupContext("__close_peak_wo_subpeaks", 0);
  __Pyx_TraceCall("__close_peak_wo_subpeaks", __pyx_f[0], 1100, 0, __PYX_ERR(0, 1100, __pyx_L1_error));
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_score_cutoff_s = __pyx_optional_args->score_cutoff_s;
    }
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1115
 *             int32_t tlist_scores_p
 * 
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]             # <<<<<<<<<<<<<<
 *         if peak_length >= min_length: # if the peak is too small, reject it
 *             tsummit = []
 */
  __Pyx_TraceLine(1115,0,__PYX_ERR(0, 1115, __pyx_L1_error))
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1115, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1115, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_GetItemInt(__pyx_t_1, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1115, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1115, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1115, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = __Pyx_GetItemInt(__pyx_t_1, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1115, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyNumber_Subtract(__pyx_t_2, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1115, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_peak_length = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1116
 * 
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *         if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *             tsummit = []
 *             summit_pos   = 0
 */
  __Pyx_TraceLine(1116,0,__PYX_ERR(0, 1116, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_min_length); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1116, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyObject_RichCompare(__pyx_v_peak_length, __pyx_t_1, Py_GE); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1116, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1116, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1117
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *         if peak_length >= min_length: # if the peak is too small, reject it
 *             tsummit = []             # <<<<<<<<<<<<<<
 *             summit_pos   = 0
 *             summit_value = 0
 */
    __Pyx_TraceLine(1117,0,__PYX_ERR(0, 1117, __pyx_L1_error))
    __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1117, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_v_tsummit = ((PyObject*)__pyx_t_3);
    __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1118
 *         if peak_length >= min_length: # if the peak is too small, reject it
 *             tsummit = []
 *             summit_pos   = 0             # <<<<<<<<<<<<<<
 *             summit_value = 0
 *             for i in range(len(peak_content)):
 */
    __Pyx_TraceLine(1118,0,__PYX_ERR(0, 1118, __pyx_L1_error))
    __pyx_v_summit_pos = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1119
 *             tsummit = []
 *             summit_pos   = 0
 *             summit_value = 0             # <<<<<<<<<<<<<<
 *             for i in range(len(peak_content)):
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 */
    __Pyx_TraceLine(1119,0,__PYX_ERR(0, 1119, __pyx_L1_error))
    __Pyx_INCREF(__pyx_int_0);
    __pyx_v_summit_value = __pyx_int_0;

    /* "MACS2/IO/CallPeakUnit.pyx":1120
 *             summit_pos   = 0
 *             summit_value = 0
 *             for i in range(len(peak_content)):             # <<<<<<<<<<<<<<
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *                 tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 */
    __Pyx_TraceLine(1120,0,__PYX_ERR(0, 1120, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1120, __pyx_L1_error)
    }
    __pyx_t_5 = PyList_GET_SIZE(__pyx_v_peak_content); if (unlikely(__pyx_t_5 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1120, __pyx_L1_error)
    __pyx_t_6 = __pyx_t_5;
    for (__pyx_t_7 = 0; __pyx_t_7 < __pyx_t_6; __pyx_t_7+=1) {
      __pyx_v_i = __pyx_t_7;

      /* "MACS2/IO/CallPeakUnit.pyx":1121
 *             summit_value = 0
 *             for i in range(len(peak_content)):
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]             # <<<<<<<<<<<<<<
 *                 tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *                 if not summit_value or summit_value < tscore:
 */
      __Pyx_TraceLine(1121,0,__PYX_ERR(0, 1121, __pyx_L1_error))
      if (unlikely(__pyx_v_peak_content == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1121, __pyx_L1_error)
      }
      __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1121, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      if ((likely(PyTuple_CheckExact(__pyx_t_3))) || (PyList_CheckExact(__pyx_t_3))) {
        PyObject* sequence = __pyx_t_3;
        Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
        if (unlikely(size != 5)) {
          if (size > 5) __Pyx_RaiseTooManyValuesError(5);
          else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
          __PYX_ERR(0, 1121, __pyx_L1_error)
        }
        #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
        if (likely(PyTuple_CheckExact(sequence))) {
          __pyx_t_1 = PyTuple_GET_ITEM(sequence, 0); 
          __pyx_t_2 = PyTuple_GET_ITEM(sequence, 1); 
          __pyx_t_8 = PyTuple_GET_ITEM(sequence, 2); 
          __pyx_t_9 = PyTuple_GET_ITEM(sequence, 3); 
          __pyx_t_10 = PyTuple_GET_ITEM(sequence, 4); 
        } else {
          __pyx_t_1 = PyList_GET_ITEM(sequence, 0); 
          __pyx_t_2 = PyList_GET_ITEM(sequence, 1); 
          __pyx_t_8 = PyList_GET_ITEM(sequence, 2); 
          __pyx_t_9 = PyList_GET_ITEM(sequence, 3); 
          __pyx_t_10 = PyList_GET_ITEM(sequence, 4); 
        }
        __Pyx_INCREF(__pyx_t_1);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_8);
        __Pyx_INCREF(__pyx_t_9);
        __Pyx_INCREF(__pyx_t_10);
        #else
        {
          Py_ssize_t i;
          PyObject** temps[5] = {&__pyx_t_1,&__pyx_t_2,&__pyx_t_8,&__pyx_t_9,&__pyx_t_10};
          for (i=0; i < 5; i++) {
            PyObject* item = PySequence_ITEM(sequence, i); if (unlikely(!item)) __PYX_ERR(0, 1121, __pyx_L1_error)
            __Pyx_GOTREF(item);
            *(temps[i]) = item;
          }
        }
        #endif
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      } else {
        Py_ssize_t index = -1;
        PyObject** temps[5] = {&__pyx_t_1,&__pyx_t_2,&__pyx_t_8,&__pyx_t_9,&__pyx_t_10};
        __pyx_t_11 = PyObject_GetIter(__pyx_t_3); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 1121, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_11);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __pyx_t_12 = Py_TYPE(__pyx_t_11)->tp_iternext;
        for (index=0; index < 5; index++) {
          PyObject* item = __pyx_t_12(__pyx_t_11); if (unlikely(!item)) goto __pyx_L6_unpacking_failed;
          __Pyx_GOTREF(item);
          *(temps[index]) = item;
        }
        if (__Pyx_IternextUnpackEndCheck(__pyx_t_12(__pyx_t_11), 5) < 0) __PYX_ERR(0, 1121, __pyx_L1_error)
        __pyx_t_12 = NULL;
        __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
        goto __pyx_L7_unpacking_done;
        __pyx_L6_unpacking_failed:;
        __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
        __pyx_t_12 = NULL;
        if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
        __PYX_ERR(0, 1121, __pyx_L1_error)
        __pyx_L7_unpacking_done:;
      }
      __pyx_t_13 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_13 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1121, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_14 = __Pyx_PyInt_As_npy_int32(__pyx_t_2); if (unlikely((__pyx_t_14 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1121, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_15 = __pyx_PyFloat_AsDouble(__pyx_t_8); if (unlikely((__pyx_t_15 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1121, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __pyx_t_16 = __pyx_PyFloat_AsDouble(__pyx_t_9); if (unlikely((__pyx_t_16 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1121, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __pyx_t_17 = __Pyx_PyInt_As_npy_int32(__pyx_t_10); if (unlikely((__pyx_t_17 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1121, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __pyx_v_tstart = __pyx_t_13;
      __pyx_v_tend = __pyx_t_14;
      __pyx_v_ttreat_p = __pyx_t_15;
      __pyx_v_tctrl_p = __pyx_t_16;
      __pyx_v_tlist_scores_p = __pyx_t_17;

      /* "MACS2/IO/CallPeakUnit.pyx":1122
 *             for i in range(len(peak_content)):
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *                 tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit             # <<<<<<<<<<<<<<
 *                 if not summit_value or summit_value < tscore:
 *                     tsummit = [(tend + tstart) // 2, ]
 */
      __Pyx_TraceLine(1122,0,__PYX_ERR(0, 1122, __pyx_L1_error))
      __pyx_v_tscore = __pyx_v_ttreat_p;

      /* "MACS2/IO/CallPeakUnit.pyx":1123
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *                 tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *                 if not summit_value or summit_value < tscore:             # <<<<<<<<<<<<<<
 *                     tsummit = [(tend + tstart) // 2, ]
 *                     tsummit_index = [ i, ]
 */
      __Pyx_TraceLine(1123,0,__PYX_ERR(0, 1123, __pyx_L1_error))
      __pyx_t_18 = __Pyx_PyObject_IsTrue(__pyx_v_summit_value); if (unlikely(__pyx_t_18 < 0)) __PYX_ERR(0, 1123, __pyx_L1_error)
      __pyx_t_19 = ((!__pyx_t_18) != 0);
      if (!__pyx_t_19) {
      } else {
        __pyx_t_4 = __pyx_t_19;
        goto __pyx_L9_bool_binop_done;
      }
      __pyx_t_3 = PyFloat_FromDouble(__pyx_v_tscore); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1123, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_10 = PyObject_RichCompare(__pyx_v_summit_value, __pyx_t_3, Py_LT); __Pyx_XGOTREF(__pyx_t_10); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1123, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_19 = __Pyx_PyObject_IsTrue(__pyx_t_10); if (unlikely(__pyx_t_19 < 0)) __PYX_ERR(0, 1123, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __pyx_t_4 = __pyx_t_19;
      __pyx_L9_bool_binop_done:;
      if (__pyx_t_4) {

        /* "MACS2/IO/CallPeakUnit.pyx":1124
 *                 tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *                 if not summit_value or summit_value < tscore:
 *                     tsummit = [(tend + tstart) // 2, ]             # <<<<<<<<<<<<<<
 *                     tsummit_index = [ i, ]
 *                     summit_value = tscore
 */
        __Pyx_TraceLine(1124,0,__PYX_ERR(0, 1124, __pyx_L1_error))
        __pyx_t_10 = __Pyx_PyInt_From_long(__Pyx_div_long((__pyx_v_tend + __pyx_v_tstart), 2)); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1124, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_10);
        __pyx_t_3 = PyList_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1124, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __Pyx_GIVEREF(__pyx_t_10);
        PyList_SET_ITEM(__pyx_t_3, 0, __pyx_t_10);
        __pyx_t_10 = 0;
        __Pyx_DECREF_SET(__pyx_v_tsummit, ((PyObject*)__pyx_t_3));
        __pyx_t_3 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1125
 *                 if not summit_value or summit_value < tscore:
 *                     tsummit = [(tend + tstart) // 2, ]
 *                     tsummit_index = [ i, ]             # <<<<<<<<<<<<<<
 *                     summit_value = tscore
 *                 elif summit_value == tscore:
 */
        __Pyx_TraceLine(1125,0,__PYX_ERR(0, 1125, __pyx_L1_error))
        __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_i); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1125, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_10 = PyList_New(1); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1125, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_10);
        __Pyx_GIVEREF(__pyx_t_3);
        PyList_SET_ITEM(__pyx_t_10, 0, __pyx_t_3);
        __pyx_t_3 = 0;
        __Pyx_XDECREF_SET(__pyx_v_tsummit_index, ((PyObject*)__pyx_t_10));
        __pyx_t_10 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1126
 *                     tsummit = [(tend + tstart) // 2, ]
 *                     tsummit_index = [ i, ]
 *                     summit_value = tscore             # <<<<<<<<<<<<<<
 *                 elif summit_value == tscore:
 *                     # remember continuous summit values
 */
        __Pyx_TraceLine(1126,0,__PYX_ERR(0, 1126, __pyx_L1_error))
        __pyx_t_10 = PyFloat_FromDouble(__pyx_v_tscore); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1126, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_10);
        __Pyx_DECREF_SET(__pyx_v_summit_value, __pyx_t_10);
        __pyx_t_10 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1123
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *                 tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *                 if not summit_value or summit_value < tscore:             # <<<<<<<<<<<<<<
 *                     tsummit = [(tend + tstart) // 2, ]
 *                     tsummit_index = [ i, ]
 */
        goto __pyx_L8;
      }

      /* "MACS2/IO/CallPeakUnit.pyx":1127
 *                     tsummit_index = [ i, ]
 *                     summit_value = tscore
 *                 elif summit_value == tscore:             # <<<<<<<<<<<<<<
 *                     # remember continuous summit values
 *                     tsummit.append((tend + tstart) // 2)
 */
      __Pyx_TraceLine(1127,0,__PYX_ERR(0, 1127, __pyx_L1_error))
      __pyx_t_10 = PyFloat_FromDouble(__pyx_v_tscore); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1127, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_10);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_summit_value, __pyx_t_10, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1127, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1127, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_4) {

        /* "MACS2/IO/CallPeakUnit.pyx":1129
 *                 elif summit_value == tscore:
 *                     # remember continuous summit values
 *                     tsummit.append((tend + tstart) // 2)             # <<<<<<<<<<<<<<
 *                     tsummit_index.append( i )
 *             # the middle of all highest points in peak region is defined as summit
 */
        __Pyx_TraceLine(1129,0,__PYX_ERR(0, 1129, __pyx_L1_error))
        __pyx_t_3 = __Pyx_PyInt_From_long(__Pyx_div_long((__pyx_v_tend + __pyx_v_tstart), 2)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1129, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_20 = __Pyx_PyList_Append(__pyx_v_tsummit, __pyx_t_3); if (unlikely(__pyx_t_20 == ((int)-1))) __PYX_ERR(0, 1129, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1130
 *                     # remember continuous summit values
 *                     tsummit.append((tend + tstart) // 2)
 *                     tsummit_index.append( i )             # <<<<<<<<<<<<<<
 *             # the middle of all highest points in peak region is defined as summit
 *             midindex = (len(tsummit) + 1) // 2 - 1
 */
        __Pyx_TraceLine(1130,0,__PYX_ERR(0, 1130, __pyx_L1_error))
        if (unlikely(!__pyx_v_tsummit_index)) { __Pyx_RaiseUnboundLocalError("tsummit_index"); __PYX_ERR(0, 1130, __pyx_L1_error) }
        __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_i); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1130, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_20 = __Pyx_PyList_Append(__pyx_v_tsummit_index, __pyx_t_3); if (unlikely(__pyx_t_20 == ((int)-1))) __PYX_ERR(0, 1130, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1127
 *                     tsummit_index = [ i, ]
 *                     summit_value = tscore
 *                 elif summit_value == tscore:             # <<<<<<<<<<<<<<
 *                     # remember continuous summit values
 *                     tsummit.append((tend + tstart) // 2)
 */
      }
      __pyx_L8:;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1132
 *                     tsummit_index.append( i )
 *             # the middle of all highest points in peak region is defined as summit
 *             midindex = (len(tsummit) + 1) // 2 - 1             # <<<<<<<<<<<<<<
 *             summit_pos    = tsummit[ midindex ]
 *             summit_index  = tsummit_index[ midindex ]
 */
    __Pyx_TraceLine(1132,0,__PYX_ERR(0, 1132, __pyx_L1_error))
    __pyx_t_5 = PyList_GET_SIZE(__pyx_v_tsummit); if (unlikely(__pyx_t_5 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1132, __pyx_L1_error)
    __pyx_v_midindex = (__Pyx_div_Py_ssize_t((__pyx_t_5 + 1), 2) - 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1133
 *             # the middle of all highest points in peak region is defined as summit
 *             midindex = (len(tsummit) + 1) // 2 - 1
 *             summit_pos    = tsummit[ midindex ]             # <<<<<<<<<<<<<<
 *             summit_index  = tsummit_index[ midindex ]
 * 
 */
    __Pyx_TraceLine(1133,0,__PYX_ERR(0, 1133, __pyx_L1_error))
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_tsummit, __pyx_v_midindex, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1133, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_7 = __Pyx_PyInt_As_npy_int32(__pyx_t_3); if (unlikely((__pyx_t_7 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1133, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_v_summit_pos = __pyx_t_7;

    /* "MACS2/IO/CallPeakUnit.pyx":1134
 *             midindex = (len(tsummit) + 1) // 2 - 1
 *             summit_pos    = tsummit[ midindex ]
 *             summit_index  = tsummit_index[ midindex ]             # <<<<<<<<<<<<<<
 * 
 *             summit_treat = peak_content[ summit_index ][ 2 ]
 */
    __Pyx_TraceLine(1134,0,__PYX_ERR(0, 1134, __pyx_L1_error))
    if (unlikely(!__pyx_v_tsummit_index)) { __Pyx_RaiseUnboundLocalError("tsummit_index"); __PYX_ERR(0, 1134, __pyx_L1_error) }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_tsummit_index, __pyx_v_midindex, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1134, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_7 = __Pyx_PyInt_As_npy_int32(__pyx_t_3); if (unlikely((__pyx_t_7 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1134, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_v_summit_index = __pyx_t_7;

    /* "MACS2/IO/CallPeakUnit.pyx":1136
 *             summit_index  = tsummit_index[ midindex ]
 * 
 *             summit_treat = peak_content[ summit_index ][ 2 ]             # <<<<<<<<<<<<<<
 *             summit_ctrl = peak_content[ summit_index ][ 3 ]
 * 
 */
    __Pyx_TraceLine(1136,0,__PYX_ERR(0, 1136, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1136, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_summit_index, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1136, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_10 = __Pyx_GetItemInt(__pyx_t_3, 2, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1136, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_16 = __pyx_PyFloat_AsDouble(__pyx_t_10); if (unlikely((__pyx_t_16 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1136, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
    __pyx_v_summit_treat = __pyx_t_16;

    /* "MACS2/IO/CallPeakUnit.pyx":1137
 * 
 *             summit_treat = peak_content[ summit_index ][ 2 ]
 *             summit_ctrl = peak_content[ summit_index ][ 3 ]             # <<<<<<<<<<<<<<
 * 
 *             # this is a double-check to see if the summit can pass cutoff values.
 */
    __Pyx_TraceLine(1137,0,__PYX_ERR(0, 1137, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1137, __pyx_L1_error)
    }
    __pyx_t_10 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_summit_index, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1137, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __pyx_t_3 = __Pyx_GetItemInt(__pyx_t_10, 3, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1137, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
    __pyx_t_16 = __pyx_PyFloat_AsDouble(__pyx_t_3); if (unlikely((__pyx_t_16 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1137, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_v_summit_ctrl = __pyx_t_16;

    /* "MACS2/IO/CallPeakUnit.pyx":1140
 * 
 *             # this is a double-check to see if the summit can pass cutoff values.
 *             for i in range(len(score_cutoff_s)):             # <<<<<<<<<<<<<<
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:
 *                     return False # not passed, then disgard this peak.
 */
    __Pyx_TraceLine(1140,0,__PYX_ERR(0, 1140, __pyx_L1_error))
    if (unlikely(__pyx_v_score_cutoff_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1140, __pyx_L1_error)
    }
    __pyx_t_5 = PyList_GET_SIZE(__pyx_v_score_cutoff_s); if (unlikely(__pyx_t_5 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1140, __pyx_L1_error)
    __pyx_t_6 = __pyx_t_5;
    for (__pyx_t_7 = 0; __pyx_t_7 < __pyx_t_6; __pyx_t_7+=1) {
      __pyx_v_i = __pyx_t_7;

      /* "MACS2/IO/CallPeakUnit.pyx":1141
 *             # this is a double-check to see if the summit can pass cutoff values.
 *             for i in range(len(score_cutoff_s)):
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:             # <<<<<<<<<<<<<<
 *                     return False # not passed, then disgard this peak.
 * 
 */
      __Pyx_TraceLine(1141,0,__PYX_ERR(0, 1141, __pyx_L1_error))
      if (unlikely(__pyx_v_score_cutoff_s == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1141, __pyx_L1_error)
      }
      __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_score_cutoff_s, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1141, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      if (unlikely(__pyx_v_score_array_s == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1141, __pyx_L1_error)
      }
      __pyx_t_10 = __Pyx_GetItemInt_List(__pyx_v_score_array_s, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1141, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_10);
      if (unlikely(__pyx_v_peak_content == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1141, __pyx_L1_error)
      }
      __pyx_t_9 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_summit_index, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1141, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_9);
      __pyx_t_8 = __Pyx_GetItemInt(__pyx_t_9, 4, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1141, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __pyx_t_9 = __Pyx_PyObject_GetItem(__pyx_t_10, __pyx_t_8); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1141, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_9);
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __pyx_t_8 = PyObject_RichCompare(__pyx_t_3, __pyx_t_9, Py_GT); __Pyx_XGOTREF(__pyx_t_8); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1141, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_8); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1141, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      if (__pyx_t_4) {

        /* "MACS2/IO/CallPeakUnit.pyx":1142
 *             for i in range(len(score_cutoff_s)):
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:
 *                     return False # not passed, then disgard this peak.             # <<<<<<<<<<<<<<
 * 
 *             #summit_p_score = get_pscore( int(summit_treat), summit_ctrl )
 */
        __Pyx_TraceLine(1142,0,__PYX_ERR(0, 1142, __pyx_L1_error))
        __Pyx_XDECREF(((PyObject *)__pyx_r));
        __Pyx_INCREF(Py_False);
        __pyx_r = ((PyBoolObject *)Py_False);
        goto __pyx_L0;

        /* "MACS2/IO/CallPeakUnit.pyx":1141
 *             # this is a double-check to see if the summit can pass cutoff values.
 *             for i in range(len(score_cutoff_s)):
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:             # <<<<<<<<<<<<<<
 *                     return False # not passed, then disgard this peak.
 * 
 */
      }
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1145
 * 
 *             #summit_p_score = get_pscore( int(summit_treat), summit_ctrl )
 *             summit_p_score = get_pscore(( <int32_t>(summit_treat), summit_ctrl ) )             # <<<<<<<<<<<<<<
 *             summit_q_score = self.pqtable[ summit_p_score ]
 * 
 */
    __Pyx_TraceLine(1145,0,__PYX_ERR(0, 1145, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyInt_From_npy_int32(((__pyx_t_5numpy_int32_t)__pyx_v_summit_treat)); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1145, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_9 = PyFloat_FromDouble(__pyx_v_summit_ctrl); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1145, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1145, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_8);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_8);
    __Pyx_GIVEREF(__pyx_t_9);
    PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_9);
    __pyx_t_8 = 0;
    __pyx_t_9 = 0;
    __pyx_v_summit_p_score = __pyx_f_5MACS2_2IO_12CallPeakUnit_get_pscore(((PyObject*)__pyx_t_3));
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1146
 *             #summit_p_score = get_pscore( int(summit_treat), summit_ctrl )
 *             summit_p_score = get_pscore(( <int32_t>(summit_treat), summit_ctrl ) )
 *             summit_q_score = self.pqtable[ summit_p_score ]             # <<<<<<<<<<<<<<
 * 
 *             peaks.add( chrom,           # chromosome
 */
    __Pyx_TraceLine(1146,0,__PYX_ERR(0, 1146, __pyx_L1_error))
    if (unlikely(__pyx_v_self->pqtable == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1146, __pyx_L1_error)
    }
    __pyx_t_3 = PyFloat_FromDouble(__pyx_v_summit_p_score); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1146, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_9 = __Pyx_PyDict_GetItem(__pyx_v_self->pqtable, __pyx_t_3); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1146, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_16 = __pyx_PyFloat_AsDouble(__pyx_t_9); if (unlikely((__pyx_t_16 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1146, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __pyx_v_summit_q_score = __pyx_t_16;

    /* "MACS2/IO/CallPeakUnit.pyx":1148
 *             summit_q_score = self.pqtable[ summit_p_score ]
 * 
 *             peaks.add( chrom,           # chromosome             # <<<<<<<<<<<<<<
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 */
    __Pyx_TraceLine(1148,0,__PYX_ERR(0, 1148, __pyx_L1_error))
    __pyx_t_9 = __Pyx_PyObject_GetAttrStr(__pyx_v_peaks, __pyx_n_s_add); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1148, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);

    /* "MACS2/IO/CallPeakUnit.pyx":1149
 * 
 *             peaks.add( chrom,           # chromosome
 *                        peak_content[0][0], # start             # <<<<<<<<<<<<<<
 *                        peak_content[-1][1], # end
 *                        summit      = summit_pos, # summit position
 */
    __Pyx_TraceLine(1149,0,__PYX_ERR(0, 1149, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1149, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1149, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_8 = __Pyx_GetItemInt(__pyx_t_3, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1149, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1150
 *             peaks.add( chrom,           # chromosome
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end             # <<<<<<<<<<<<<<
 *                        summit      = summit_pos, # summit position
 *                        peak_score  = summit_q_score, # score at summit
 */
    __Pyx_TraceLine(1150,0,__PYX_ERR(0, 1150, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1150, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1150, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_10 = __Pyx_GetItemInt(__pyx_t_3, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1150, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1148
 *             summit_q_score = self.pqtable[ summit_p_score ]
 * 
 *             peaks.add( chrom,           # chromosome             # <<<<<<<<<<<<<<
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 */
    __Pyx_TraceLine(1148,0,__PYX_ERR(0, 1148, __pyx_L1_error))
    __pyx_t_3 = PyTuple_New(3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1148, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_INCREF(__pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_v_chrom);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_t_8);
    PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_8);
    __Pyx_GIVEREF(__pyx_t_10);
    PyTuple_SET_ITEM(__pyx_t_3, 2, __pyx_t_10);
    __pyx_t_8 = 0;
    __pyx_t_10 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1151
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 *                        summit      = summit_pos, # summit position             # <<<<<<<<<<<<<<
 *                        peak_score  = summit_q_score, # score at summit
 *                        pileup      = summit_treat, # pileup
 */
    __Pyx_TraceLine(1151,0,__PYX_ERR(0, 1151, __pyx_L1_error))
    __pyx_t_10 = __Pyx_PyDict_NewPresized(6); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __pyx_t_8 = __Pyx_PyInt_From_npy_int32(__pyx_v_summit_pos); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_10, __pyx_n_s_summit, __pyx_t_8) < 0) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1152
 *                        peak_content[-1][1], # end
 *                        summit      = summit_pos, # summit position
 *                        peak_score  = summit_q_score, # score at summit             # <<<<<<<<<<<<<<
 *                        pileup      = summit_treat, # pileup
 *                        pscore      = summit_p_score, # pvalue
 */
    __Pyx_TraceLine(1152,0,__PYX_ERR(0, 1152, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_v_summit_q_score); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1152, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_10, __pyx_n_s_peak_score, __pyx_t_8) < 0) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1153
 *                        summit      = summit_pos, # summit position
 *                        peak_score  = summit_q_score, # score at summit
 *                        pileup      = summit_treat, # pileup             # <<<<<<<<<<<<<<
 *                        pscore      = summit_p_score, # pvalue
 *                        fold_change = ( summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change
 */
    __Pyx_TraceLine(1153,0,__PYX_ERR(0, 1153, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_v_summit_treat); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1153, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_10, __pyx_n_s_pileup, __pyx_t_8) < 0) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1154
 *                        peak_score  = summit_q_score, # score at summit
 *                        pileup      = summit_treat, # pileup
 *                        pscore      = summit_p_score, # pvalue             # <<<<<<<<<<<<<<
 *                        fold_change = ( summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change
 *                        qscore      = summit_q_score # qvalue
 */
    __Pyx_TraceLine(1154,0,__PYX_ERR(0, 1154, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_v_summit_p_score); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1154, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_10, __pyx_n_s_pscore, __pyx_t_8) < 0) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1155
 *                        pileup      = summit_treat, # pileup
 *                        pscore      = summit_p_score, # pvalue
 *                        fold_change = ( summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change             # <<<<<<<<<<<<<<
 *                        qscore      = summit_q_score # qvalue
 *                        )
 */
    __Pyx_TraceLine(1155,0,__PYX_ERR(0, 1155, __pyx_L1_error))
    __pyx_t_16 = (__pyx_v_summit_treat + __pyx_v_self->pseudocount);
    __pyx_t_15 = (__pyx_v_summit_ctrl + __pyx_v_self->pseudocount);
    if (unlikely(__pyx_t_15 == 0)) {
      PyErr_SetString(PyExc_ZeroDivisionError, "float division");
      __PYX_ERR(0, 1155, __pyx_L1_error)
    }
    __pyx_t_8 = PyFloat_FromDouble((__pyx_t_16 / __pyx_t_15)); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1155, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_10, __pyx_n_s_fold_change, __pyx_t_8) < 0) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1156
 *                        pscore      = summit_p_score, # pvalue
 *                        fold_change = ( summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change
 *                        qscore      = summit_q_score # qvalue             # <<<<<<<<<<<<<<
 *                        )
 *             # start a new peak
 */
    __Pyx_TraceLine(1156,0,__PYX_ERR(0, 1156, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_v_summit_q_score); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1156, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_10, __pyx_n_s_qscore, __pyx_t_8) < 0) __PYX_ERR(0, 1151, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1148
 *             summit_q_score = self.pqtable[ summit_p_score ]
 * 
 *             peaks.add( chrom,           # chromosome             # <<<<<<<<<<<<<<
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 */
    __Pyx_TraceLine(1148,0,__PYX_ERR(0, 1148, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyObject_Call(__pyx_t_9, __pyx_t_3, __pyx_t_10); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1148, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1159
 *                        )
 *             # start a new peak
 *             return True             # <<<<<<<<<<<<<<
 * 
 *     cdef bool __close_peak_with_subpeaks (self, list peak_content, peaks, int32_t min_length,
 */
    __Pyx_TraceLine(1159,0,__PYX_ERR(0, 1159, __pyx_L1_error))
    __Pyx_XDECREF(((PyObject *)__pyx_r));
    __Pyx_INCREF(Py_True);
    __pyx_r = ((PyBoolObject *)Py_True);
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1116
 * 
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *         if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *             tsummit = []
 *             summit_pos   = 0
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1100
 *         return
 * 
 *     cdef bool __close_peak_wo_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                           bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the peak region, output peak boundaries, peak summit
 */

  /* function exit code */
  __pyx_r = ((PyBoolObject *)Py_None); __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_XDECREF(__pyx_t_9);
  __Pyx_XDECREF(__pyx_t_10);
  __Pyx_XDECREF(__pyx_t_11);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__close_peak_wo_subpeaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_peak_length);
  __Pyx_XDECREF(__pyx_v_tsummit);
  __Pyx_XDECREF(__pyx_v_summit_value);
  __Pyx_XDECREF(__pyx_v_tsummit_index);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1161
 *             return True
 * 
 *     cdef bool __close_peak_with_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                          bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[],
 *                                          float32_t min_valley = 0.9 ):
 */

static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peak_content, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_min_length, PyObject *__pyx_v_chrom, __pyx_t_5numpy_int32_t __pyx_v_smoothlen, PyObject *__pyx_v_score_array_s, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks *__pyx_optional_args) {
  PyObject *__pyx_v_score_cutoff_s = __pyx_k__12;
  __pyx_t_5numpy_int32_t __pyx_v_tstart;
  __pyx_t_5numpy_int32_t __pyx_v_tend;
  __pyx_t_5numpy_int32_t __pyx_v_summit_index;
  __pyx_t_5numpy_int32_t __pyx_v_summit_offset;
  __pyx_t_5numpy_int32_t __pyx_v_start;
  __pyx_t_5numpy_int32_t __pyx_v_end;
  __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_int32_t __pyx_v_start_boundary;
  __pyx_t_5numpy_int32_t __pyx_v_m;
  __pyx_t_5numpy_int32_t __pyx_v_n;
  __pyx_t_5numpy_float64_t __pyx_v_ttreat_p;
  CYTHON_UNUSED __pyx_t_5numpy_float64_t __pyx_v_tctrl_p;
  __pyx_t_5numpy_float64_t __pyx_v_tscore;
  __pyx_t_5numpy_float64_t __pyx_v_summit_treat;
  __pyx_t_5numpy_float64_t __pyx_v_summit_ctrl;
  __pyx_t_5numpy_float64_t __pyx_v_summit_p_score;
  __pyx_t_5numpy_float64_t __pyx_v_summit_q_score;
  PyArrayObject *__pyx_v_peakdata = 0;
  PyArrayObject *__pyx_v_peakindices = 0;
  PyArrayObject *__pyx_v_summit_offsets = 0;
  CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_tlist_scores_p;
  PyObject *__pyx_v_peak_length = NULL;
  PyObject *__pyx_v_summit_indices = NULL;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_peakdata;
  __Pyx_Buffer __pyx_pybuffer_peakdata;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_peakindices;
  __Pyx_Buffer __pyx_pybuffer_peakindices;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_summit_offsets;
  __Pyx_Buffer __pyx_pybuffer_summit_offsets;
  PyBoolObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  __pyx_t_5numpy_int32_t __pyx_t_5;
  PyObject *__pyx_t_6 = NULL;
  PyArrayObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  PyObject *__pyx_t_9 = NULL;
  PyObject *__pyx_t_10 = NULL;
  PyObject *__pyx_t_11 = NULL;
  PyArrayObject *__pyx_t_12 = NULL;
  Py_ssize_t __pyx_t_13;
  Py_ssize_t __pyx_t_14;
  PyObject *__pyx_t_15 = NULL;
  PyObject *__pyx_t_16 = NULL;
  PyObject *__pyx_t_17 = NULL;
  PyObject *(*__pyx_t_18)(PyObject *);
  __pyx_t_5numpy_int32_t __pyx_t_19;
  __pyx_t_5numpy_int32_t __pyx_t_20;
  __pyx_t_5numpy_float64_t __pyx_t_21;
  __pyx_t_5numpy_float64_t __pyx_t_22;
  __pyx_t_5numpy_int32_t __pyx_t_23;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks __pyx_t_24;
  Py_ssize_t __pyx_t_25;
  __Pyx_RefNannySetupContext("__close_peak_with_subpeaks", 0);
  __Pyx_TraceCall("__close_peak_with_subpeaks", __pyx_f[0], 1161, 0, __PYX_ERR(0, 1161, __pyx_L1_error));
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_score_cutoff_s = __pyx_optional_args->score_cutoff_s;
    }
  }
  __pyx_pybuffer_peakdata.pybuffer.buf = NULL;
  __pyx_pybuffer_peakdata.refcount = 0;
  __pyx_pybuffernd_peakdata.data = NULL;
  __pyx_pybuffernd_peakdata.rcbuffer = &__pyx_pybuffer_peakdata;
  __pyx_pybuffer_peakindices.pybuffer.buf = NULL;
  __pyx_pybuffer_peakindices.refcount = 0;
  __pyx_pybuffernd_peakindices.data = NULL;
  __pyx_pybuffernd_peakindices.rcbuffer = &__pyx_pybuffer_peakindices;
  __pyx_pybuffer_summit_offsets.pybuffer.buf = NULL;
  __pyx_pybuffer_summit_offsets.refcount = 0;
  __pyx_pybuffernd_summit_offsets.data = NULL;
  __pyx_pybuffernd_summit_offsets.rcbuffer = &__pyx_pybuffer_summit_offsets;

  /* "MACS2/IO/CallPeakUnit.pyx":1177
 *             int32_t tlist_scores_p
 * 
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]             # <<<<<<<<<<<<<<
 * 
 *         if peak_length < min_length: return  # if the region is too small, reject it
 */
  __Pyx_TraceLine(1177,0,__PYX_ERR(0, 1177, __pyx_L1_error))
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1177, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_GetItemInt(__pyx_t_1, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1177, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = __Pyx_GetItemInt(__pyx_t_1, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyNumber_Subtract(__pyx_t_2, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1177, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_peak_length = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1179
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 * 
 *         if peak_length < min_length: return  # if the region is too small, reject it             # <<<<<<<<<<<<<<
 * 
 *         # Add 10 bp padding to peak region so that we can get true minima
 */
  __Pyx_TraceLine(1179,0,__PYX_ERR(0, 1179, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_min_length); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1179, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyObject_RichCompare(__pyx_v_peak_length, __pyx_t_1, Py_LT); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1179, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1179, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (__pyx_t_4) {
    __Pyx_XDECREF(((PyObject *)__pyx_r));
    __pyx_r = ((PyBoolObject *)Py_None); __Pyx_INCREF(Py_None);
    goto __pyx_L0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1182
 * 
 *         # Add 10 bp padding to peak region so that we can get true minima
 *         end = peak_content[ -1 ][ 1 ] + 10             # <<<<<<<<<<<<<<
 *         start = peak_content[ 0 ][ 0 ] - 10
 *         if start < 0:
 */
  __Pyx_TraceLine(1182,0,__PYX_ERR(0, 1182, __pyx_L1_error))
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1182, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1182, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_1 = __Pyx_GetItemInt(__pyx_t_3, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1182, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = __Pyx_PyInt_AddObjC(__pyx_t_1, __pyx_int_10, 10, 0, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1182, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_5 = __Pyx_PyInt_As_npy_int32(__pyx_t_3); if (unlikely((__pyx_t_5 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1182, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_end = __pyx_t_5;

  /* "MACS2/IO/CallPeakUnit.pyx":1183
 *         # Add 10 bp padding to peak region so that we can get true minima
 *         end = peak_content[ -1 ][ 1 ] + 10
 *         start = peak_content[ 0 ][ 0 ] - 10             # <<<<<<<<<<<<<<
 *         if start < 0:
 *             start_boundary = 10 + start # this is the offset of original peak boundary in peakdata list.
 */
  __Pyx_TraceLine(1183,0,__PYX_ERR(0, 1183, __pyx_L1_error))
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1183, __pyx_L1_error)
  }
  __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1183, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_1 = __Pyx_GetItemInt(__pyx_t_3, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1183, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = __Pyx_PyInt_SubtractObjC(__pyx_t_1, __pyx_int_10, 10, 0, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1183, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_5 = __Pyx_PyInt_As_npy_int32(__pyx_t_3); if (unlikely((__pyx_t_5 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1183, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_start = __pyx_t_5;

  /* "MACS2/IO/CallPeakUnit.pyx":1184
 *         end = peak_content[ -1 ][ 1 ] + 10
 *         start = peak_content[ 0 ][ 0 ] - 10
 *         if start < 0:             # <<<<<<<<<<<<<<
 *             start_boundary = 10 + start # this is the offset of original peak boundary in peakdata list.
 *             start = 0
 */
  __Pyx_TraceLine(1184,0,__PYX_ERR(0, 1184, __pyx_L1_error))
  __pyx_t_4 = ((__pyx_v_start < 0) != 0);
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1185
 *         start = peak_content[ 0 ][ 0 ] - 10
 *         if start < 0:
 *             start_boundary = 10 + start # this is the offset of original peak boundary in peakdata list.             # <<<<<<<<<<<<<<
 *             start = 0
 *         else:
 */
    __Pyx_TraceLine(1185,0,__PYX_ERR(0, 1185, __pyx_L1_error))
    __pyx_v_start_boundary = (10 + __pyx_v_start);

    /* "MACS2/IO/CallPeakUnit.pyx":1186
 *         if start < 0:
 *             start_boundary = 10 + start # this is the offset of original peak boundary in peakdata list.
 *             start = 0             # <<<<<<<<<<<<<<
 *         else:
 *             start_boundary = 10 # this is the offset of original peak boundary in peakdata list.
 */
    __Pyx_TraceLine(1186,0,__PYX_ERR(0, 1186, __pyx_L1_error))
    __pyx_v_start = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1184
 *         end = peak_content[ -1 ][ 1 ] + 10
 *         start = peak_content[ 0 ][ 0 ] - 10
 *         if start < 0:             # <<<<<<<<<<<<<<
 *             start_boundary = 10 + start # this is the offset of original peak boundary in peakdata list.
 *             start = 0
 */
    goto __pyx_L4;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1188
 *             start = 0
 *         else:
 *             start_boundary = 10 # this is the offset of original peak boundary in peakdata list.             # <<<<<<<<<<<<<<
 * 
 *         peakdata = np.zeros(end - start, dtype='float32') # save the scores (qscore) for each position in this region
 */
  __Pyx_TraceLine(1188,0,__PYX_ERR(0, 1188, __pyx_L1_error))
  /*else*/ {
    __pyx_v_start_boundary = 10;
  }
  __pyx_L4:;

  /* "MACS2/IO/CallPeakUnit.pyx":1190
 *             start_boundary = 10 # this is the offset of original peak boundary in peakdata list.
 * 
 *         peakdata = np.zeros(end - start, dtype='float32') # save the scores (qscore) for each position in this region             # <<<<<<<<<<<<<<
 *         peakindices = np.zeros(end - start, dtype='int32') # save the indices for each position in this region
 *         for i in range(len(peak_content)):
 */
  __Pyx_TraceLine(1190,0,__PYX_ERR(0, 1190, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_np); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1190, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_zeros); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1190, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32((__pyx_v_end - __pyx_v_start)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1190, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1190, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_GIVEREF(__pyx_t_3);
  PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_t_3);
  __pyx_t_3 = 0;
  __pyx_t_3 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1190, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  if (PyDict_SetItem(__pyx_t_3, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1190, __pyx_L1_error)
  __pyx_t_6 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_2, __pyx_t_3); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1190, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_6) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_6, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1190, __pyx_L1_error)
  __pyx_t_7 = ((PyArrayObject *)__pyx_t_6);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_peakdata.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_peakdata.rcbuffer->pybuffer, (PyObject*)__pyx_t_7, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_10, &__pyx_t_11);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_peakdata.rcbuffer->pybuffer, (PyObject*)__pyx_v_peakdata, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_11);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_10, __pyx_t_11);
      }
      __pyx_t_9 = __pyx_t_10 = __pyx_t_11 = 0;
    }
    __pyx_pybuffernd_peakdata.diminfo[0].strides = __pyx_pybuffernd_peakdata.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_peakdata.diminfo[0].shape = __pyx_pybuffernd_peakdata.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1190, __pyx_L1_error)
  }
  __pyx_t_7 = 0;
  __pyx_v_peakdata = ((PyArrayObject *)__pyx_t_6);
  __pyx_t_6 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1191
 * 
 *         peakdata = np.zeros(end - start, dtype='float32') # save the scores (qscore) for each position in this region
 *         peakindices = np.zeros(end - start, dtype='int32') # save the indices for each position in this region             # <<<<<<<<<<<<<<
 *         for i in range(len(peak_content)):
 *             (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 */
  __Pyx_TraceLine(1191,0,__PYX_ERR(0, 1191, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_np); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_zeros); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = __Pyx_PyInt_From_npy_int32((__pyx_v_end - __pyx_v_start)); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_2 = PyTuple_New(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_GIVEREF(__pyx_t_6);
  PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_t_6);
  __pyx_t_6 = 0;
  __pyx_t_6 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_dtype, __pyx_n_u_int32) < 0) __PYX_ERR(0, 1191, __pyx_L1_error)
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_3, __pyx_t_2, __pyx_t_6); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1191, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1191, __pyx_L1_error)
  __pyx_t_12 = ((PyArrayObject *)__pyx_t_1);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_peakindices.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_peakindices.rcbuffer->pybuffer, (PyObject*)__pyx_t_12, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_11, &__pyx_t_10, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_peakindices.rcbuffer->pybuffer, (PyObject*)__pyx_v_peakindices, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_11); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_11, __pyx_t_10, __pyx_t_9);
      }
      __pyx_t_11 = __pyx_t_10 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_peakindices.diminfo[0].strides = __pyx_pybuffernd_peakindices.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_peakindices.diminfo[0].shape = __pyx_pybuffernd_peakindices.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1191, __pyx_L1_error)
  }
  __pyx_t_12 = 0;
  __pyx_v_peakindices = ((PyArrayObject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1192
 *         peakdata = np.zeros(end - start, dtype='float32') # save the scores (qscore) for each position in this region
 *         peakindices = np.zeros(end - start, dtype='int32') # save the indices for each position in this region
 *         for i in range(len(peak_content)):             # <<<<<<<<<<<<<<
 *             (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *             #tscore = self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 */
  __Pyx_TraceLine(1192,0,__PYX_ERR(0, 1192, __pyx_L1_error))
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 1192, __pyx_L1_error)
  }
  __pyx_t_13 = PyList_GET_SIZE(__pyx_v_peak_content); if (unlikely(__pyx_t_13 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1192, __pyx_L1_error)
  __pyx_t_14 = __pyx_t_13;
  for (__pyx_t_5 = 0; __pyx_t_5 < __pyx_t_14; __pyx_t_5+=1) {
    __pyx_v_i = __pyx_t_5;

    /* "MACS2/IO/CallPeakUnit.pyx":1193
 *         peakindices = np.zeros(end - start, dtype='int32') # save the indices for each position in this region
 *         for i in range(len(peak_content)):
 *             (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]             # <<<<<<<<<<<<<<
 *             #tscore = self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *             tscore = ttreat_p # use pileup as general score to find summit
 */
    __Pyx_TraceLine(1193,0,__PYX_ERR(0, 1193, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1193, __pyx_L1_error)
    }
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1193, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if ((likely(PyTuple_CheckExact(__pyx_t_1))) || (PyList_CheckExact(__pyx_t_1))) {
      PyObject* sequence = __pyx_t_1;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 5)) {
        if (size > 5) __Pyx_RaiseTooManyValuesError(5);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 1193, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      if (likely(PyTuple_CheckExact(sequence))) {
        __pyx_t_6 = PyTuple_GET_ITEM(sequence, 0); 
        __pyx_t_2 = PyTuple_GET_ITEM(sequence, 1); 
        __pyx_t_3 = PyTuple_GET_ITEM(sequence, 2); 
        __pyx_t_15 = PyTuple_GET_ITEM(sequence, 3); 
        __pyx_t_16 = PyTuple_GET_ITEM(sequence, 4); 
      } else {
        __pyx_t_6 = PyList_GET_ITEM(sequence, 0); 
        __pyx_t_2 = PyList_GET_ITEM(sequence, 1); 
        __pyx_t_3 = PyList_GET_ITEM(sequence, 2); 
        __pyx_t_15 = PyList_GET_ITEM(sequence, 3); 
        __pyx_t_16 = PyList_GET_ITEM(sequence, 4); 
      }
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_15);
      __Pyx_INCREF(__pyx_t_16);
      #else
      {
        Py_ssize_t i;
        PyObject** temps[5] = {&__pyx_t_6,&__pyx_t_2,&__pyx_t_3,&__pyx_t_15,&__pyx_t_16};
        for (i=0; i < 5; i++) {
          PyObject* item = PySequence_ITEM(sequence, i); if (unlikely(!item)) __PYX_ERR(0, 1193, __pyx_L1_error)
          __Pyx_GOTREF(item);
          *(temps[i]) = item;
        }
      }
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    } else {
      Py_ssize_t index = -1;
      PyObject** temps[5] = {&__pyx_t_6,&__pyx_t_2,&__pyx_t_3,&__pyx_t_15,&__pyx_t_16};
      __pyx_t_17 = PyObject_GetIter(__pyx_t_1); if (unlikely(!__pyx_t_17)) __PYX_ERR(0, 1193, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_17);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_18 = Py_TYPE(__pyx_t_17)->tp_iternext;
      for (index=0; index < 5; index++) {
        PyObject* item = __pyx_t_18(__pyx_t_17); if (unlikely(!item)) goto __pyx_L7_unpacking_failed;
        __Pyx_GOTREF(item);
        *(temps[index]) = item;
      }
      if (__Pyx_IternextUnpackEndCheck(__pyx_t_18(__pyx_t_17), 5) < 0) __PYX_ERR(0, 1193, __pyx_L1_error)
      __pyx_t_18 = NULL;
      __Pyx_DECREF(__pyx_t_17); __pyx_t_17 = 0;
      goto __pyx_L8_unpacking_done;
      __pyx_L7_unpacking_failed:;
      __Pyx_DECREF(__pyx_t_17); __pyx_t_17 = 0;
      __pyx_t_18 = NULL;
      if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
      __PYX_ERR(0, 1193, __pyx_L1_error)
      __pyx_L8_unpacking_done:;
    }
    __pyx_t_19 = __Pyx_PyInt_As_npy_int32(__pyx_t_6); if (unlikely((__pyx_t_19 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1193, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __pyx_t_20 = __Pyx_PyInt_As_npy_int32(__pyx_t_2); if (unlikely((__pyx_t_20 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1193, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_21 = __pyx_PyFloat_AsDouble(__pyx_t_3); if (unlikely((__pyx_t_21 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1193, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_22 = __pyx_PyFloat_AsDouble(__pyx_t_15); if (unlikely((__pyx_t_22 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1193, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    __pyx_t_23 = __Pyx_PyInt_As_npy_int32(__pyx_t_16); if (unlikely((__pyx_t_23 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1193, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    __pyx_v_tstart = __pyx_t_19;
    __pyx_v_tend = __pyx_t_20;
    __pyx_v_ttreat_p = __pyx_t_21;
    __pyx_v_tctrl_p = __pyx_t_22;
    __pyx_v_tlist_scores_p = __pyx_t_23;

    /* "MACS2/IO/CallPeakUnit.pyx":1195
 *             (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *             #tscore = self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *             tscore = ttreat_p # use pileup as general score to find summit             # <<<<<<<<<<<<<<
 *             m = tstart - start + start_boundary
 *             n = tend - start + start_boundary
 */
    __Pyx_TraceLine(1195,0,__PYX_ERR(0, 1195, __pyx_L1_error))
    __pyx_v_tscore = __pyx_v_ttreat_p;

    /* "MACS2/IO/CallPeakUnit.pyx":1196
 *             #tscore = self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *             tscore = ttreat_p # use pileup as general score to find summit
 *             m = tstart - start + start_boundary             # <<<<<<<<<<<<<<
 *             n = tend - start + start_boundary
 *             peakdata[m:n] = tscore
 */
    __Pyx_TraceLine(1196,0,__PYX_ERR(0, 1196, __pyx_L1_error))
    __pyx_v_m = ((__pyx_v_tstart - __pyx_v_start) + __pyx_v_start_boundary);

    /* "MACS2/IO/CallPeakUnit.pyx":1197
 *             tscore = ttreat_p # use pileup as general score to find summit
 *             m = tstart - start + start_boundary
 *             n = tend - start + start_boundary             # <<<<<<<<<<<<<<
 *             peakdata[m:n] = tscore
 *             peakindices[m:n] = i
 */
    __Pyx_TraceLine(1197,0,__PYX_ERR(0, 1197, __pyx_L1_error))
    __pyx_v_n = ((__pyx_v_tend - __pyx_v_start) + __pyx_v_start_boundary);

    /* "MACS2/IO/CallPeakUnit.pyx":1198
 *             m = tstart - start + start_boundary
 *             n = tend - start + start_boundary
 *             peakdata[m:n] = tscore             # <<<<<<<<<<<<<<
 *             peakindices[m:n] = i
 * 
 */
    __Pyx_TraceLine(1198,0,__PYX_ERR(0, 1198, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_tscore); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1198, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_16 = __Pyx_PyInt_From_npy_int32(__pyx_v_m); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1198, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __pyx_t_15 = __Pyx_PyInt_From_npy_int32(__pyx_v_n); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1198, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __pyx_t_3 = PySlice_New(__pyx_t_16, __pyx_t_15, Py_None); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1198, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    if (unlikely(PyObject_SetItem(((PyObject *)__pyx_v_peakdata), __pyx_t_3, __pyx_t_1) < 0)) __PYX_ERR(0, 1198, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1199
 *             n = tend - start + start_boundary
 *             peakdata[m:n] = tscore
 *             peakindices[m:n] = i             # <<<<<<<<<<<<<<
 * 
 *         summit_offsets = maxima(peakdata, smoothlen) # offsets are the indices for summits in peakdata/peakindices array.
 */
    __Pyx_TraceLine(1199,0,__PYX_ERR(0, 1199, __pyx_L1_error))
    __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_i); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1199, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_m); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1199, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_15 = __Pyx_PyInt_From_npy_int32(__pyx_v_n); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1199, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __pyx_t_16 = PySlice_New(__pyx_t_3, __pyx_t_15, Py_None); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1199, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    if (unlikely(PyObject_SetItem(((PyObject *)__pyx_v_peakindices), __pyx_t_16, __pyx_t_1) < 0)) __PYX_ERR(0, 1199, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1201
 *             peakindices[m:n] = i
 * 
 *         summit_offsets = maxima(peakdata, smoothlen) # offsets are the indices for summits in peakdata/peakindices array.             # <<<<<<<<<<<<<<
 * 
 *         if summit_offsets.shape[0] == 0:
 */
  __Pyx_TraceLine(1201,0,__PYX_ERR(0, 1201, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_16, __pyx_n_s_maxima); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1201, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_16);
  __pyx_t_15 = __Pyx_PyInt_From_npy_int32(__pyx_v_smoothlen); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1201, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_15);
  __pyx_t_3 = NULL;
  __pyx_t_8 = 0;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_16))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_16);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_16);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_16, function);
      __pyx_t_8 = 1;
    }
  }
  #if CYTHON_FAST_PYCALL
  if (PyFunction_Check(__pyx_t_16)) {
    PyObject *__pyx_temp[3] = {__pyx_t_3, ((PyObject *)__pyx_v_peakdata), __pyx_t_15};
    __pyx_t_1 = __Pyx_PyFunction_FastCall(__pyx_t_16, __pyx_temp+1-__pyx_t_8, 2+__pyx_t_8); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1201, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
  } else
  #endif
  #if CYTHON_FAST_PYCCALL
  if (__Pyx_PyFastCFunction_Check(__pyx_t_16)) {
    PyObject *__pyx_temp[3] = {__pyx_t_3, ((PyObject *)__pyx_v_peakdata), __pyx_t_15};
    __pyx_t_1 = __Pyx_PyCFunction_FastCall(__pyx_t_16, __pyx_temp+1-__pyx_t_8, 2+__pyx_t_8); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1201, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
  } else
  #endif
  {
    __pyx_t_2 = PyTuple_New(2+__pyx_t_8); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1201, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    if (__pyx_t_3) {
      __Pyx_GIVEREF(__pyx_t_3); PyTuple_SET_ITEM(__pyx_t_2, 0, __pyx_t_3); __pyx_t_3 = NULL;
    }
    __Pyx_INCREF(((PyObject *)__pyx_v_peakdata));
    __Pyx_GIVEREF(((PyObject *)__pyx_v_peakdata));
    PyTuple_SET_ITEM(__pyx_t_2, 0+__pyx_t_8, ((PyObject *)__pyx_v_peakdata));
    __Pyx_GIVEREF(__pyx_t_15);
    PyTuple_SET_ITEM(__pyx_t_2, 1+__pyx_t_8, __pyx_t_15);
    __pyx_t_15 = 0;
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_16, __pyx_t_2, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1201, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  }
  __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
  if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1201, __pyx_L1_error)
  __pyx_t_12 = ((PyArrayObject *)__pyx_t_1);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_t_12, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_10, &__pyx_t_11);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_v_summit_offsets, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_11);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_10, __pyx_t_11);
      }
      __pyx_t_9 = __pyx_t_10 = __pyx_t_11 = 0;
    }
    __pyx_pybuffernd_summit_offsets.diminfo[0].strides = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_summit_offsets.diminfo[0].shape = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1201, __pyx_L1_error)
  }
  __pyx_t_12 = 0;
  __pyx_v_summit_offsets = ((PyArrayObject *)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1203
 *         summit_offsets = maxima(peakdata, smoothlen) # offsets are the indices for summits in peakdata/peakindices array.
 * 
 *         if summit_offsets.shape[0] == 0:             # <<<<<<<<<<<<<<
 *             # **failsafe** if no summits, fall back on old approach #
 *             return self.__close_peak_wo_subpeaks(peak_content, peaks, min_length, chrom, smoothlen, score_array_s, score_cutoff_s)
 */
  __Pyx_TraceLine(1203,0,__PYX_ERR(0, 1203, __pyx_L1_error))
  __pyx_t_4 = (((__pyx_v_summit_offsets->dimensions[0]) == 0) != 0);
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1205
 *         if summit_offsets.shape[0] == 0:
 *             # **failsafe** if no summits, fall back on old approach #
 *             return self.__close_peak_wo_subpeaks(peak_content, peaks, min_length, chrom, smoothlen, score_array_s, score_cutoff_s)             # <<<<<<<<<<<<<<
 *         else:
 *             # remove maxima that occurred in padding
 */
    __Pyx_TraceLine(1205,0,__PYX_ERR(0, 1205, __pyx_L1_error))
    __Pyx_XDECREF(((PyObject *)__pyx_r));
    __pyx_t_24.__pyx_n = 1;
    __pyx_t_24.score_cutoff_s = __pyx_v_score_cutoff_s;
    __pyx_t_1 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_wo_subpeaks(__pyx_v_self, __pyx_v_peak_content, __pyx_v_peaks, __pyx_v_min_length, __pyx_v_chrom, __pyx_v_smoothlen, __pyx_v_score_array_s, &__pyx_t_24)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1205, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_r = ((PyBoolObject *)__pyx_t_1);
    __pyx_t_1 = 0;
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1203
 *         summit_offsets = maxima(peakdata, smoothlen) # offsets are the indices for summits in peakdata/peakindices array.
 * 
 *         if summit_offsets.shape[0] == 0:             # <<<<<<<<<<<<<<
 *             # **failsafe** if no summits, fall back on old approach #
 *             return self.__close_peak_wo_subpeaks(peak_content, peaks, min_length, chrom, smoothlen, score_array_s, score_cutoff_s)
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1208
 *         else:
 *             # remove maxima that occurred in padding
 *             m = np.searchsorted(summit_offsets, start_boundary)             # <<<<<<<<<<<<<<
 *             n = np.searchsorted(summit_offsets, peak_length + start_boundary, 'right')
 *             summit_offsets = summit_offsets[m:n]
 */
  __Pyx_TraceLine(1208,0,__PYX_ERR(0, 1208, __pyx_L1_error))
  /*else*/ {
    __Pyx_GetModuleGlobalName(__pyx_t_16, __pyx_n_s_np); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1208, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_16, __pyx_n_s_searchsorted); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1208, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    __pyx_t_16 = __Pyx_PyInt_From_npy_int32(__pyx_v_start_boundary); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1208, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __pyx_t_15 = NULL;
    __pyx_t_8 = 0;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_15 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_15)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_15);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
        __pyx_t_8 = 1;
      }
    }
    #if CYTHON_FAST_PYCALL
    if (PyFunction_Check(__pyx_t_2)) {
      PyObject *__pyx_temp[3] = {__pyx_t_15, ((PyObject *)__pyx_v_summit_offsets), __pyx_t_16};
      __pyx_t_1 = __Pyx_PyFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_8, 2+__pyx_t_8); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1208, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_15); __pyx_t_15 = 0;
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    } else
    #endif
    #if CYTHON_FAST_PYCCALL
    if (__Pyx_PyFastCFunction_Check(__pyx_t_2)) {
      PyObject *__pyx_temp[3] = {__pyx_t_15, ((PyObject *)__pyx_v_summit_offsets), __pyx_t_16};
      __pyx_t_1 = __Pyx_PyCFunction_FastCall(__pyx_t_2, __pyx_temp+1-__pyx_t_8, 2+__pyx_t_8); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1208, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_15); __pyx_t_15 = 0;
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    } else
    #endif
    {
      __pyx_t_3 = PyTuple_New(2+__pyx_t_8); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1208, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      if (__pyx_t_15) {
        __Pyx_GIVEREF(__pyx_t_15); PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_15); __pyx_t_15 = NULL;
      }
      __Pyx_INCREF(((PyObject *)__pyx_v_summit_offsets));
      __Pyx_GIVEREF(((PyObject *)__pyx_v_summit_offsets));
      PyTuple_SET_ITEM(__pyx_t_3, 0+__pyx_t_8, ((PyObject *)__pyx_v_summit_offsets));
      __Pyx_GIVEREF(__pyx_t_16);
      PyTuple_SET_ITEM(__pyx_t_3, 1+__pyx_t_8, __pyx_t_16);
      __pyx_t_16 = 0;
      __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1208, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    }
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_5 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_5 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1208, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_m = __pyx_t_5;

    /* "MACS2/IO/CallPeakUnit.pyx":1209
 *             # remove maxima that occurred in padding
 *             m = np.searchsorted(summit_offsets, start_boundary)
 *             n = np.searchsorted(summit_offsets, peak_length + start_boundary, 'right')             # <<<<<<<<<<<<<<
 *             summit_offsets = summit_offsets[m:n]
 * 
 */
    __Pyx_TraceLine(1209,0,__PYX_ERR(0, 1209, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_np); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1209, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_searchsorted); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1209, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyInt_From_npy_int32(__pyx_v_start_boundary); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1209, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_16 = PyNumber_Add(__pyx_v_peak_length, __pyx_t_2); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1209, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = NULL;
    __pyx_t_8 = 0;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_3))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_3);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_3);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_3, function);
        __pyx_t_8 = 1;
      }
    }
    #if CYTHON_FAST_PYCALL
    if (PyFunction_Check(__pyx_t_3)) {
      PyObject *__pyx_temp[4] = {__pyx_t_2, ((PyObject *)__pyx_v_summit_offsets), __pyx_t_16, __pyx_n_u_right};
      __pyx_t_1 = __Pyx_PyFunction_FastCall(__pyx_t_3, __pyx_temp+1-__pyx_t_8, 3+__pyx_t_8); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1209, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    } else
    #endif
    #if CYTHON_FAST_PYCCALL
    if (__Pyx_PyFastCFunction_Check(__pyx_t_3)) {
      PyObject *__pyx_temp[4] = {__pyx_t_2, ((PyObject *)__pyx_v_summit_offsets), __pyx_t_16, __pyx_n_u_right};
      __pyx_t_1 = __Pyx_PyCFunction_FastCall(__pyx_t_3, __pyx_temp+1-__pyx_t_8, 3+__pyx_t_8); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1209, __pyx_L1_error)
      __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    } else
    #endif
    {
      __pyx_t_15 = PyTuple_New(3+__pyx_t_8); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1209, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_15);
      if (__pyx_t_2) {
        __Pyx_GIVEREF(__pyx_t_2); PyTuple_SET_ITEM(__pyx_t_15, 0, __pyx_t_2); __pyx_t_2 = NULL;
      }
      __Pyx_INCREF(((PyObject *)__pyx_v_summit_offsets));
      __Pyx_GIVEREF(((PyObject *)__pyx_v_summit_offsets));
      PyTuple_SET_ITEM(__pyx_t_15, 0+__pyx_t_8, ((PyObject *)__pyx_v_summit_offsets));
      __Pyx_GIVEREF(__pyx_t_16);
      PyTuple_SET_ITEM(__pyx_t_15, 1+__pyx_t_8, __pyx_t_16);
      __Pyx_INCREF(__pyx_n_u_right);
      __Pyx_GIVEREF(__pyx_n_u_right);
      PyTuple_SET_ITEM(__pyx_t_15, 2+__pyx_t_8, __pyx_n_u_right);
      __pyx_t_16 = 0;
      __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_3, __pyx_t_15, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1209, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    }
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_5 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_5 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1209, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_n = __pyx_t_5;

    /* "MACS2/IO/CallPeakUnit.pyx":1210
 *             m = np.searchsorted(summit_offsets, start_boundary)
 *             n = np.searchsorted(summit_offsets, peak_length + start_boundary, 'right')
 *             summit_offsets = summit_offsets[m:n]             # <<<<<<<<<<<<<<
 * 
 *         summit_offsets = enforce_peakyness(peakdata, summit_offsets)
 */
    __Pyx_TraceLine(1210,0,__PYX_ERR(0, 1210, __pyx_L1_error))
    __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_m); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1210, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_n); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1210, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_15 = PySlice_New(__pyx_t_1, __pyx_t_3, Py_None); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1210, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_summit_offsets), __pyx_t_15); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1210, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1210, __pyx_L1_error)
    __pyx_t_12 = ((PyArrayObject *)__pyx_t_3);
    {
      __Pyx_BufFmt_StackElem __pyx_stack[1];
      __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer);
      __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_t_12, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
      if (unlikely(__pyx_t_8 < 0)) {
        PyErr_Fetch(&__pyx_t_11, &__pyx_t_10, &__pyx_t_9);
        if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_v_summit_offsets, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
          Py_XDECREF(__pyx_t_11); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_9);
          __Pyx_RaiseBufferFallbackError();
        } else {
          PyErr_Restore(__pyx_t_11, __pyx_t_10, __pyx_t_9);
        }
        __pyx_t_11 = __pyx_t_10 = __pyx_t_9 = 0;
      }
      __pyx_pybuffernd_summit_offsets.diminfo[0].strides = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_summit_offsets.diminfo[0].shape = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.shape[0];
      if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1210, __pyx_L1_error)
    }
    __pyx_t_12 = 0;
    __Pyx_DECREF_SET(__pyx_v_summit_offsets, ((PyArrayObject *)__pyx_t_3));
    __pyx_t_3 = 0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1212
 *             summit_offsets = summit_offsets[m:n]
 * 
 *         summit_offsets = enforce_peakyness(peakdata, summit_offsets)             # <<<<<<<<<<<<<<
 * 
 *         #print "enforced:",summit_offsets
 */
  __Pyx_TraceLine(1212,0,__PYX_ERR(0, 1212, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_15, __pyx_n_s_enforce_peakyness); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1212, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_15);
  __pyx_t_1 = NULL;
  __pyx_t_8 = 0;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_15))) {
    __pyx_t_1 = PyMethod_GET_SELF(__pyx_t_15);
    if (likely(__pyx_t_1)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_15);
      __Pyx_INCREF(__pyx_t_1);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_15, function);
      __pyx_t_8 = 1;
    }
  }
  #if CYTHON_FAST_PYCALL
  if (PyFunction_Check(__pyx_t_15)) {
    PyObject *__pyx_temp[3] = {__pyx_t_1, ((PyObject *)__pyx_v_peakdata), ((PyObject *)__pyx_v_summit_offsets)};
    __pyx_t_3 = __Pyx_PyFunction_FastCall(__pyx_t_15, __pyx_temp+1-__pyx_t_8, 2+__pyx_t_8); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1212, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_GOTREF(__pyx_t_3);
  } else
  #endif
  #if CYTHON_FAST_PYCCALL
  if (__Pyx_PyFastCFunction_Check(__pyx_t_15)) {
    PyObject *__pyx_temp[3] = {__pyx_t_1, ((PyObject *)__pyx_v_peakdata), ((PyObject *)__pyx_v_summit_offsets)};
    __pyx_t_3 = __Pyx_PyCFunction_FastCall(__pyx_t_15, __pyx_temp+1-__pyx_t_8, 2+__pyx_t_8); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1212, __pyx_L1_error)
    __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_GOTREF(__pyx_t_3);
  } else
  #endif
  {
    __pyx_t_16 = PyTuple_New(2+__pyx_t_8); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1212, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    if (__pyx_t_1) {
      __Pyx_GIVEREF(__pyx_t_1); PyTuple_SET_ITEM(__pyx_t_16, 0, __pyx_t_1); __pyx_t_1 = NULL;
    }
    __Pyx_INCREF(((PyObject *)__pyx_v_peakdata));
    __Pyx_GIVEREF(((PyObject *)__pyx_v_peakdata));
    PyTuple_SET_ITEM(__pyx_t_16, 0+__pyx_t_8, ((PyObject *)__pyx_v_peakdata));
    __Pyx_INCREF(((PyObject *)__pyx_v_summit_offsets));
    __Pyx_GIVEREF(((PyObject *)__pyx_v_summit_offsets));
    PyTuple_SET_ITEM(__pyx_t_16, 1+__pyx_t_8, ((PyObject *)__pyx_v_summit_offsets));
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_t_15, __pyx_t_16, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1212, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
  }
  __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
  if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1212, __pyx_L1_error)
  __pyx_t_12 = ((PyArrayObject *)__pyx_t_3);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_t_12, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_10, &__pyx_t_11);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_v_summit_offsets, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_11);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_10, __pyx_t_11);
      }
      __pyx_t_9 = __pyx_t_10 = __pyx_t_11 = 0;
    }
    __pyx_pybuffernd_summit_offsets.diminfo[0].strides = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_summit_offsets.diminfo[0].shape = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1212, __pyx_L1_error)
  }
  __pyx_t_12 = 0;
  __Pyx_DECREF_SET(__pyx_v_summit_offsets, ((PyArrayObject *)__pyx_t_3));
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1215
 * 
 *         #print "enforced:",summit_offsets
 *         if summit_offsets.shape[0] == 0:             # <<<<<<<<<<<<<<
 *             # **failsafe** if no summits, fall back on old approach #
 *             return self.__close_peak_wo_subpeaks(peak_content, peaks, min_length, chrom, smoothlen, score_array_s, score_cutoff_s)
 */
  __Pyx_TraceLine(1215,0,__PYX_ERR(0, 1215, __pyx_L1_error))
  __pyx_t_4 = (((__pyx_v_summit_offsets->dimensions[0]) == 0) != 0);
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1217
 *         if summit_offsets.shape[0] == 0:
 *             # **failsafe** if no summits, fall back on old approach #
 *             return self.__close_peak_wo_subpeaks(peak_content, peaks, min_length, chrom, smoothlen, score_array_s, score_cutoff_s)             # <<<<<<<<<<<<<<
 * 
 *         summit_indices = peakindices[summit_offsets] # indices are those point to peak_content
 */
    __Pyx_TraceLine(1217,0,__PYX_ERR(0, 1217, __pyx_L1_error))
    __Pyx_XDECREF(((PyObject *)__pyx_r));
    __pyx_t_24.__pyx_n = 1;
    __pyx_t_24.score_cutoff_s = __pyx_v_score_cutoff_s;
    __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_wo_subpeaks(__pyx_v_self, __pyx_v_peak_content, __pyx_v_peaks, __pyx_v_min_length, __pyx_v_chrom, __pyx_v_smoothlen, __pyx_v_score_array_s, &__pyx_t_24)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1217, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_r = ((PyBoolObject *)__pyx_t_3);
    __pyx_t_3 = 0;
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1215
 * 
 *         #print "enforced:",summit_offsets
 *         if summit_offsets.shape[0] == 0:             # <<<<<<<<<<<<<<
 *             # **failsafe** if no summits, fall back on old approach #
 *             return self.__close_peak_wo_subpeaks(peak_content, peaks, min_length, chrom, smoothlen, score_array_s, score_cutoff_s)
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1219
 *             return self.__close_peak_wo_subpeaks(peak_content, peaks, min_length, chrom, smoothlen, score_array_s, score_cutoff_s)
 * 
 *         summit_indices = peakindices[summit_offsets] # indices are those point to peak_content             # <<<<<<<<<<<<<<
 *         summit_offsets -= start_boundary
 * 
 */
  __Pyx_TraceLine(1219,0,__PYX_ERR(0, 1219, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_peakindices), ((PyObject *)__pyx_v_summit_offsets)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1219, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_v_summit_indices = __pyx_t_3;
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1220
 * 
 *         summit_indices = peakindices[summit_offsets] # indices are those point to peak_content
 *         summit_offsets -= start_boundary             # <<<<<<<<<<<<<<
 * 
 *         for summit_offset, summit_index in list(zip(summit_offsets, summit_indices)):
 */
  __Pyx_TraceLine(1220,0,__PYX_ERR(0, 1220, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_start_boundary); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1220, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_15 = PyNumber_InPlaceSubtract(((PyObject *)__pyx_v_summit_offsets), __pyx_t_3); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1220, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_15);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_15) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_15, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1220, __pyx_L1_error)
  __pyx_t_12 = ((PyArrayObject *)__pyx_t_15);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer);
    __pyx_t_8 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_t_12, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_8 < 0)) {
      PyErr_Fetch(&__pyx_t_11, &__pyx_t_10, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer, (PyObject*)__pyx_v_summit_offsets, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_11); Py_XDECREF(__pyx_t_10); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_11, __pyx_t_10, __pyx_t_9);
      }
      __pyx_t_11 = __pyx_t_10 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_summit_offsets.diminfo[0].strides = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_summit_offsets.diminfo[0].shape = __pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_8 < 0)) __PYX_ERR(0, 1220, __pyx_L1_error)
  }
  __pyx_t_12 = 0;
  __Pyx_DECREF_SET(__pyx_v_summit_offsets, ((PyArrayObject *)__pyx_t_15));
  __pyx_t_15 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1222
 *         summit_offsets -= start_boundary
 * 
 *         for summit_offset, summit_index in list(zip(summit_offsets, summit_indices)):             # <<<<<<<<<<<<<<
 * 
 *             summit_treat = peak_content[ summit_index ][ 2 ]
 */
  __Pyx_TraceLine(1222,0,__PYX_ERR(0, 1222, __pyx_L1_error))
  __pyx_t_15 = PyTuple_New(2); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1222, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_15);
  __Pyx_INCREF(((PyObject *)__pyx_v_summit_offsets));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_summit_offsets));
  PyTuple_SET_ITEM(__pyx_t_15, 0, ((PyObject *)__pyx_v_summit_offsets));
  __Pyx_INCREF(__pyx_v_summit_indices);
  __Pyx_GIVEREF(__pyx_v_summit_indices);
  PyTuple_SET_ITEM(__pyx_t_15, 1, __pyx_v_summit_indices);
  __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_zip, __pyx_t_15, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1222, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
  __pyx_t_15 = PySequence_List(__pyx_t_3); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1222, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_15);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_3 = __pyx_t_15; __Pyx_INCREF(__pyx_t_3); __pyx_t_13 = 0;
  __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
  for (;;) {
    if (__pyx_t_13 >= PyList_GET_SIZE(__pyx_t_3)) break;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_15 = PyList_GET_ITEM(__pyx_t_3, __pyx_t_13); __Pyx_INCREF(__pyx_t_15); __pyx_t_13++; if (unlikely(0 < 0)) __PYX_ERR(0, 1222, __pyx_L1_error)
    #else
    __pyx_t_15 = PySequence_ITEM(__pyx_t_3, __pyx_t_13); __pyx_t_13++; if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1222, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    #endif
    if ((likely(PyTuple_CheckExact(__pyx_t_15))) || (PyList_CheckExact(__pyx_t_15))) {
      PyObject* sequence = __pyx_t_15;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 2)) {
        if (size > 2) __Pyx_RaiseTooManyValuesError(2);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 1222, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      if (likely(PyTuple_CheckExact(sequence))) {
        __pyx_t_16 = PyTuple_GET_ITEM(sequence, 0); 
        __pyx_t_1 = PyTuple_GET_ITEM(sequence, 1); 
      } else {
        __pyx_t_16 = PyList_GET_ITEM(sequence, 0); 
        __pyx_t_1 = PyList_GET_ITEM(sequence, 1); 
      }
      __Pyx_INCREF(__pyx_t_16);
      __Pyx_INCREF(__pyx_t_1);
      #else
      __pyx_t_16 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1222, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_16);
      __pyx_t_1 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1222, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      #endif
      __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    } else {
      Py_ssize_t index = -1;
      __pyx_t_2 = PyObject_GetIter(__pyx_t_15); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1222, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
      __pyx_t_18 = Py_TYPE(__pyx_t_2)->tp_iternext;
      index = 0; __pyx_t_16 = __pyx_t_18(__pyx_t_2); if (unlikely(!__pyx_t_16)) goto __pyx_L13_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_16);
      index = 1; __pyx_t_1 = __pyx_t_18(__pyx_t_2); if (unlikely(!__pyx_t_1)) goto __pyx_L13_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_1);
      if (__Pyx_IternextUnpackEndCheck(__pyx_t_18(__pyx_t_2), 2) < 0) __PYX_ERR(0, 1222, __pyx_L1_error)
      __pyx_t_18 = NULL;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      goto __pyx_L14_unpacking_done;
      __pyx_L13_unpacking_failed:;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_18 = NULL;
      if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
      __PYX_ERR(0, 1222, __pyx_L1_error)
      __pyx_L14_unpacking_done:;
    }
    __pyx_t_5 = __Pyx_PyInt_As_npy_int32(__pyx_t_16); if (unlikely((__pyx_t_5 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1222, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    __pyx_t_23 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_23 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1222, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_summit_offset = __pyx_t_5;
    __pyx_v_summit_index = __pyx_t_23;

    /* "MACS2/IO/CallPeakUnit.pyx":1224
 *         for summit_offset, summit_index in list(zip(summit_offsets, summit_indices)):
 * 
 *             summit_treat = peak_content[ summit_index ][ 2 ]             # <<<<<<<<<<<<<<
 *             summit_ctrl = peak_content[ summit_index ][ 3 ]
 * 
 */
    __Pyx_TraceLine(1224,0,__PYX_ERR(0, 1224, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1224, __pyx_L1_error)
    }
    __pyx_t_15 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_summit_index, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1224, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __pyx_t_1 = __Pyx_GetItemInt(__pyx_t_15, 2, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1224, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    __pyx_t_22 = __pyx_PyFloat_AsDouble(__pyx_t_1); if (unlikely((__pyx_t_22 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1224, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_summit_treat = __pyx_t_22;

    /* "MACS2/IO/CallPeakUnit.pyx":1225
 * 
 *             summit_treat = peak_content[ summit_index ][ 2 ]
 *             summit_ctrl = peak_content[ summit_index ][ 3 ]             # <<<<<<<<<<<<<<
 * 
 *             #summit_p_score = get_pscore( int(summit_treat), summit_ctrl )
 */
    __Pyx_TraceLine(1225,0,__PYX_ERR(0, 1225, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1225, __pyx_L1_error)
    }
    __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_summit_index, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1225, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_15 = __Pyx_GetItemInt(__pyx_t_1, 3, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1225, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_22 = __pyx_PyFloat_AsDouble(__pyx_t_15); if (unlikely((__pyx_t_22 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1225, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    __pyx_v_summit_ctrl = __pyx_t_22;

    /* "MACS2/IO/CallPeakUnit.pyx":1228
 * 
 *             #summit_p_score = get_pscore( int(summit_treat), summit_ctrl )
 *             summit_p_score = get_pscore(( <int32_t>(summit_treat), summit_ctrl ) )             # <<<<<<<<<<<<<<
 *             summit_q_score = self.pqtable[ summit_p_score ]
 * 
 */
    __Pyx_TraceLine(1228,0,__PYX_ERR(0, 1228, __pyx_L1_error))
    __pyx_t_15 = __Pyx_PyInt_From_npy_int32(((__pyx_t_5numpy_int32_t)__pyx_v_summit_treat)); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1228, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_summit_ctrl); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1228, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_16 = PyTuple_New(2); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1228, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __Pyx_GIVEREF(__pyx_t_15);
    PyTuple_SET_ITEM(__pyx_t_16, 0, __pyx_t_15);
    __Pyx_GIVEREF(__pyx_t_1);
    PyTuple_SET_ITEM(__pyx_t_16, 1, __pyx_t_1);
    __pyx_t_15 = 0;
    __pyx_t_1 = 0;
    __pyx_v_summit_p_score = __pyx_f_5MACS2_2IO_12CallPeakUnit_get_pscore(((PyObject*)__pyx_t_16));
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1229
 *             #summit_p_score = get_pscore( int(summit_treat), summit_ctrl )
 *             summit_p_score = get_pscore(( <int32_t>(summit_treat), summit_ctrl ) )
 *             summit_q_score = self.pqtable[ summit_p_score ]             # <<<<<<<<<<<<<<
 * 
 *             for i in range(len(score_cutoff_s)):
 */
    __Pyx_TraceLine(1229,0,__PYX_ERR(0, 1229, __pyx_L1_error))
    if (unlikely(__pyx_v_self->pqtable == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1229, __pyx_L1_error)
    }
    __pyx_t_16 = PyFloat_FromDouble(__pyx_v_summit_p_score); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1229, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __pyx_t_1 = __Pyx_PyDict_GetItem(__pyx_v_self->pqtable, __pyx_t_16); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1229, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    __pyx_t_22 = __pyx_PyFloat_AsDouble(__pyx_t_1); if (unlikely((__pyx_t_22 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1229, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_v_summit_q_score = __pyx_t_22;

    /* "MACS2/IO/CallPeakUnit.pyx":1231
 *             summit_q_score = self.pqtable[ summit_p_score ]
 * 
 *             for i in range(len(score_cutoff_s)):             # <<<<<<<<<<<<<<
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:
 *                     return False # not passed, then disgard this summit.
 */
    __Pyx_TraceLine(1231,0,__PYX_ERR(0, 1231, __pyx_L1_error))
    if (unlikely(__pyx_v_score_cutoff_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1231, __pyx_L1_error)
    }
    __pyx_t_14 = PyList_GET_SIZE(__pyx_v_score_cutoff_s); if (unlikely(__pyx_t_14 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1231, __pyx_L1_error)
    __pyx_t_25 = __pyx_t_14;
    for (__pyx_t_23 = 0; __pyx_t_23 < __pyx_t_25; __pyx_t_23+=1) {
      __pyx_v_i = __pyx_t_23;

      /* "MACS2/IO/CallPeakUnit.pyx":1232
 * 
 *             for i in range(len(score_cutoff_s)):
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:             # <<<<<<<<<<<<<<
 *                     return False # not passed, then disgard this summit.
 * 
 */
      __Pyx_TraceLine(1232,0,__PYX_ERR(0, 1232, __pyx_L1_error))
      if (unlikely(__pyx_v_score_cutoff_s == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1232, __pyx_L1_error)
      }
      __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_score_cutoff_s, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1232, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (unlikely(__pyx_v_score_array_s == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1232, __pyx_L1_error)
      }
      __pyx_t_16 = __Pyx_GetItemInt_List(__pyx_v_score_array_s, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1232, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_16);
      if (unlikely(__pyx_v_peak_content == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1232, __pyx_L1_error)
      }
      __pyx_t_15 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_summit_index, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1232, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_15);
      __pyx_t_2 = __Pyx_GetItemInt(__pyx_t_15, 4, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1232, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
      __pyx_t_15 = __Pyx_PyObject_GetItem(__pyx_t_16, __pyx_t_2); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1232, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_15);
      __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_2 = PyObject_RichCompare(__pyx_t_1, __pyx_t_15, Py_GT); __Pyx_XGOTREF(__pyx_t_2); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1232, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
      __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_2); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1232, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (__pyx_t_4) {

        /* "MACS2/IO/CallPeakUnit.pyx":1233
 *             for i in range(len(score_cutoff_s)):
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:
 *                     return False # not passed, then disgard this summit.             # <<<<<<<<<<<<<<
 * 
 *             peaks.add( chrom,
 */
        __Pyx_TraceLine(1233,0,__PYX_ERR(0, 1233, __pyx_L1_error))
        __Pyx_XDECREF(((PyObject *)__pyx_r));
        __Pyx_INCREF(Py_False);
        __pyx_r = ((PyBoolObject *)Py_False);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        goto __pyx_L0;

        /* "MACS2/IO/CallPeakUnit.pyx":1232
 * 
 *             for i in range(len(score_cutoff_s)):
 *                 if score_cutoff_s[i] > score_array_s[ i ][ peak_content[ summit_index ][ 4 ] ]:             # <<<<<<<<<<<<<<
 *                     return False # not passed, then disgard this summit.
 * 
 */
      }
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1235
 *                     return False # not passed, then disgard this summit.
 * 
 *             peaks.add( chrom,             # <<<<<<<<<<<<<<
 *                        peak_content[ 0 ][ 0 ],
 *                        peak_content[ -1 ][ 1 ],
 */
    __Pyx_TraceLine(1235,0,__PYX_ERR(0, 1235, __pyx_L1_error))
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_peaks, __pyx_n_s_add); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1235, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);

    /* "MACS2/IO/CallPeakUnit.pyx":1236
 * 
 *             peaks.add( chrom,
 *                        peak_content[ 0 ][ 0 ],             # <<<<<<<<<<<<<<
 *                        peak_content[ -1 ][ 1 ],
 *                        summit      = start + summit_offset,
 */
    __Pyx_TraceLine(1236,0,__PYX_ERR(0, 1236, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1236, __pyx_L1_error)
    }
    __pyx_t_15 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1236, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __pyx_t_1 = __Pyx_GetItemInt(__pyx_t_15, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1236, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1237
 *             peaks.add( chrom,
 *                        peak_content[ 0 ][ 0 ],
 *                        peak_content[ -1 ][ 1 ],             # <<<<<<<<<<<<<<
 *                        summit      = start + summit_offset,
 *                        peak_score  = summit_q_score,
 */
    __Pyx_TraceLine(1237,0,__PYX_ERR(0, 1237, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1237, __pyx_L1_error)
    }
    __pyx_t_15 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1237, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __pyx_t_16 = __Pyx_GetItemInt(__pyx_t_15, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1237, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1235
 *                     return False # not passed, then disgard this summit.
 * 
 *             peaks.add( chrom,             # <<<<<<<<<<<<<<
 *                        peak_content[ 0 ][ 0 ],
 *                        peak_content[ -1 ][ 1 ],
 */
    __Pyx_TraceLine(1235,0,__PYX_ERR(0, 1235, __pyx_L1_error))
    __pyx_t_15 = PyTuple_New(3); if (unlikely(!__pyx_t_15)) __PYX_ERR(0, 1235, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_15);
    __Pyx_INCREF(__pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_v_chrom);
    PyTuple_SET_ITEM(__pyx_t_15, 0, __pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_t_1);
    PyTuple_SET_ITEM(__pyx_t_15, 1, __pyx_t_1);
    __Pyx_GIVEREF(__pyx_t_16);
    PyTuple_SET_ITEM(__pyx_t_15, 2, __pyx_t_16);
    __pyx_t_1 = 0;
    __pyx_t_16 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1238
 *                        peak_content[ 0 ][ 0 ],
 *                        peak_content[ -1 ][ 1 ],
 *                        summit      = start + summit_offset,             # <<<<<<<<<<<<<<
 *                        peak_score  = summit_q_score,
 *                        pileup      = summit_treat,
 */
    __Pyx_TraceLine(1238,0,__PYX_ERR(0, 1238, __pyx_L1_error))
    __pyx_t_16 = __Pyx_PyDict_NewPresized(6); if (unlikely(!__pyx_t_16)) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_16);
    __pyx_t_1 = __Pyx_PyInt_From_npy_int32((__pyx_v_start + __pyx_v_summit_offset)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (PyDict_SetItem(__pyx_t_16, __pyx_n_s_summit, __pyx_t_1) < 0) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1239
 *                        peak_content[ -1 ][ 1 ],
 *                        summit      = start + summit_offset,
 *                        peak_score  = summit_q_score,             # <<<<<<<<<<<<<<
 *                        pileup      = summit_treat,
 *                        pscore      = summit_p_score,
 */
    __Pyx_TraceLine(1239,0,__PYX_ERR(0, 1239, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_summit_q_score); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1239, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (PyDict_SetItem(__pyx_t_16, __pyx_n_s_peak_score, __pyx_t_1) < 0) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1240
 *                        summit      = start + summit_offset,
 *                        peak_score  = summit_q_score,
 *                        pileup      = summit_treat,             # <<<<<<<<<<<<<<
 *                        pscore      = summit_p_score,
 *                        fold_change = (summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change
 */
    __Pyx_TraceLine(1240,0,__PYX_ERR(0, 1240, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_summit_treat); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1240, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (PyDict_SetItem(__pyx_t_16, __pyx_n_s_pileup, __pyx_t_1) < 0) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1241
 *                        peak_score  = summit_q_score,
 *                        pileup      = summit_treat,
 *                        pscore      = summit_p_score,             # <<<<<<<<<<<<<<
 *                        fold_change = (summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change
 *                        qscore      = summit_q_score
 */
    __Pyx_TraceLine(1241,0,__PYX_ERR(0, 1241, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_summit_p_score); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1241, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (PyDict_SetItem(__pyx_t_16, __pyx_n_s_pscore, __pyx_t_1) < 0) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1242
 *                        pileup      = summit_treat,
 *                        pscore      = summit_p_score,
 *                        fold_change = (summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change             # <<<<<<<<<<<<<<
 *                        qscore      = summit_q_score
 *                        )
 */
    __Pyx_TraceLine(1242,0,__PYX_ERR(0, 1242, __pyx_L1_error))
    __pyx_t_22 = (__pyx_v_summit_treat + __pyx_v_self->pseudocount);
    __pyx_t_21 = (__pyx_v_summit_ctrl + __pyx_v_self->pseudocount);
    if (unlikely(__pyx_t_21 == 0)) {
      PyErr_SetString(PyExc_ZeroDivisionError, "float division");
      __PYX_ERR(0, 1242, __pyx_L1_error)
    }
    __pyx_t_1 = PyFloat_FromDouble((__pyx_t_22 / __pyx_t_21)); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1242, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (PyDict_SetItem(__pyx_t_16, __pyx_n_s_fold_change, __pyx_t_1) < 0) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1243
 *                        pscore      = summit_p_score,
 *                        fold_change = (summit_treat + self.pseudocount ) / ( summit_ctrl + self.pseudocount ), # fold change
 *                        qscore      = summit_q_score             # <<<<<<<<<<<<<<
 *                        )
 *         # start a new peak
 */
    __Pyx_TraceLine(1243,0,__PYX_ERR(0, 1243, __pyx_L1_error))
    __pyx_t_1 = PyFloat_FromDouble(__pyx_v_summit_q_score); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1243, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (PyDict_SetItem(__pyx_t_16, __pyx_n_s_qscore, __pyx_t_1) < 0) __PYX_ERR(0, 1238, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1235
 *                     return False # not passed, then disgard this summit.
 * 
 *             peaks.add( chrom,             # <<<<<<<<<<<<<<
 *                        peak_content[ 0 ][ 0 ],
 *                        peak_content[ -1 ][ 1 ],
 */
    __Pyx_TraceLine(1235,0,__PYX_ERR(0, 1235, __pyx_L1_error))
    __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_15, __pyx_t_16); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1235, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_15); __pyx_t_15 = 0;
    __Pyx_DECREF(__pyx_t_16); __pyx_t_16 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1222
 *         summit_offsets -= start_boundary
 * 
 *         for summit_offset, summit_index in list(zip(summit_offsets, summit_indices)):             # <<<<<<<<<<<<<<
 * 
 *             summit_treat = peak_content[ summit_index ][ 2 ]
 */
    __Pyx_TraceLine(1222,0,__PYX_ERR(0, 1222, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1246
 *                        )
 *         # start a new peak
 *         return True             # <<<<<<<<<<<<<<
 * 
 *     cdef np.ndarray __cal_pscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):
 */
  __Pyx_TraceLine(1246,0,__PYX_ERR(0, 1246, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(Py_True);
  __pyx_r = ((PyBoolObject *)Py_True);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1161
 *             return True
 * 
 *     cdef bool __close_peak_with_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                          bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[],
 *                                          float32_t min_valley = 0.9 ):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_15);
  __Pyx_XDECREF(__pyx_t_16);
  __Pyx_XDECREF(__pyx_t_17);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_peakdata.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_peakindices.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__close_peak_with_subpeaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_peakdata.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_peakindices.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_summit_offsets.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_peakdata);
  __Pyx_XDECREF((PyObject *)__pyx_v_peakindices);
  __Pyx_XDECREF((PyObject *)__pyx_v_summit_offsets);
  __Pyx_XDECREF(__pyx_v_peak_length);
  __Pyx_XDECREF(__pyx_v_summit_indices);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1248
 *         return True
 * 
 *     cdef np.ndarray __cal_pscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_pscore(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2) {
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_i;
  __pyx_t_5numpy_int64_t __pyx_v_array1_size;
  PyArrayObject *__pyx_v_s = 0;
  __pyx_t_5numpy_float32_t *__pyx_v_a1_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_a2_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_s_ptr;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array1;
  __Pyx_Buffer __pyx_pybuffer_array1;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array2;
  __Pyx_Buffer __pyx_pybuffer_array2;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_s;
  __Pyx_Buffer __pyx_pybuffer_s;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  __pyx_t_5numpy_int64_t __pyx_t_10;
  __pyx_t_5numpy_int64_t __pyx_t_11;
  __pyx_t_5numpy_int64_t __pyx_t_12;
  __Pyx_RefNannySetupContext("__cal_pscore", 0);
  __Pyx_TraceCall("__cal_pscore", __pyx_f[0], 1248, 0, __PYX_ERR(0, 1248, __pyx_L1_error));
  __pyx_pybuffer_s.pybuffer.buf = NULL;
  __pyx_pybuffer_s.refcount = 0;
  __pyx_pybuffernd_s.data = NULL;
  __pyx_pybuffernd_s.rcbuffer = &__pyx_pybuffer_s;
  __pyx_pybuffer_array1.pybuffer.buf = NULL;
  __pyx_pybuffer_array1.refcount = 0;
  __pyx_pybuffernd_array1.data = NULL;
  __pyx_pybuffernd_array1.rcbuffer = &__pyx_pybuffer_array1;
  __pyx_pybuffer_array2.pybuffer.buf = NULL;
  __pyx_pybuffer_array2.refcount = 0;
  __pyx_pybuffernd_array2.data = NULL;
  __pyx_pybuffernd_array2.rcbuffer = &__pyx_pybuffer_array2;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array1.rcbuffer->pybuffer, (PyObject*)__pyx_v_array1, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1248, __pyx_L1_error)
  }
  __pyx_pybuffernd_array1.diminfo[0].strides = __pyx_pybuffernd_array1.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array1.diminfo[0].shape = __pyx_pybuffernd_array1.rcbuffer->pybuffer.shape[0];
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array2.rcbuffer->pybuffer, (PyObject*)__pyx_v_array2, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1248, __pyx_L1_error)
  }
  __pyx_pybuffernd_array2.diminfo[0].strides = __pyx_pybuffernd_array2.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array2.diminfo[0].shape = __pyx_pybuffernd_array2.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":1256
 *             float32_t * s_ptr
 * 
 *         assert array1.shape[0] == array2.shape[0]             # <<<<<<<<<<<<<<
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 */
  __Pyx_TraceLine(1256,0,__PYX_ERR(0, 1256, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(!(((__pyx_v_array1->dimensions[0]) == (__pyx_v_array2->dimensions[0])) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 1256, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1257
 * 
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")             # <<<<<<<<<<<<<<
 * 
 *         a1_ptr = <float32_t *> array1.data
 */
  __Pyx_TraceLine(1257,0,__PYX_ERR(0, 1257, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1257, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1257, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_array1->dimensions[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1257, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1257, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1257, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1257, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1257, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1257, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_v_s, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_s.diminfo[0].strides = __pyx_pybuffernd_s.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_s.diminfo[0].shape = __pyx_pybuffernd_s.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1257, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_s = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1259
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 *         a1_ptr = <float32_t *> array1.data             # <<<<<<<<<<<<<<
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data
 */
  __Pyx_TraceLine(1259,0,__PYX_ERR(0, 1259, __pyx_L1_error))
  __pyx_v_a1_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array1->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1260
 * 
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data             # <<<<<<<<<<<<<<
 *         s_ptr = <float32_t *> s.data
 * 
 */
  __Pyx_TraceLine(1260,0,__PYX_ERR(0, 1260, __pyx_L1_error))
  __pyx_v_a2_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array2->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1261
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data             # <<<<<<<<<<<<<<
 * 
 *         array1_size = array1.shape[0]
 */
  __Pyx_TraceLine(1261,0,__PYX_ERR(0, 1261, __pyx_L1_error))
  __pyx_v_s_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_s->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1263
 *         s_ptr = <float32_t *> s.data
 * 
 *         array1_size = array1.shape[0]             # <<<<<<<<<<<<<<
 * 
 *         for i in range(array1_size):
 */
  __Pyx_TraceLine(1263,0,__PYX_ERR(0, 1263, __pyx_L1_error))
  __pyx_v_array1_size = (__pyx_v_array1->dimensions[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1265
 *         array1_size = array1.shape[0]
 * 
 *         for i in range(array1_size):             # <<<<<<<<<<<<<<
 *             #s_ptr[0] = get_pscore( int(a1_ptr[0]), a2_ptr[0] )
 *             s_ptr[0] = get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] ))
 */
  __Pyx_TraceLine(1265,0,__PYX_ERR(0, 1265, __pyx_L1_error))
  __pyx_t_10 = __pyx_v_array1_size;
  __pyx_t_11 = __pyx_t_10;
  for (__pyx_t_12 = 0; __pyx_t_12 < __pyx_t_11; __pyx_t_12+=1) {
    __pyx_v_i = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":1267
 *         for i in range(array1_size):
 *             #s_ptr[0] = get_pscore( int(a1_ptr[0]), a2_ptr[0] )
 *             s_ptr[0] = get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] ))             # <<<<<<<<<<<<<<
 *             s_ptr += 1
 *             a1_ptr += 1
 */
    __Pyx_TraceLine(1267,0,__PYX_ERR(0, 1267, __pyx_L1_error))
    __pyx_t_4 = __Pyx_PyInt_From_npy_int32(((__pyx_t_5numpy_int32_t)(__pyx_v_a1_ptr[0]))); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1267, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyFloat_FromDouble((__pyx_v_a2_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1267, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1267, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_1);
    PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    (__pyx_v_s_ptr[0]) = __pyx_f_5MACS2_2IO_12CallPeakUnit_get_pscore(((PyObject*)__pyx_t_3));
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1268
 *             #s_ptr[0] = get_pscore( int(a1_ptr[0]), a2_ptr[0] )
 *             s_ptr[0] = get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] ))
 *             s_ptr += 1             # <<<<<<<<<<<<<<
 *             a1_ptr += 1
 *             a2_ptr += 1
 */
    __Pyx_TraceLine(1268,0,__PYX_ERR(0, 1268, __pyx_L1_error))
    __pyx_v_s_ptr = (__pyx_v_s_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1269
 *             s_ptr[0] = get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] ))
 *             s_ptr += 1
 *             a1_ptr += 1             # <<<<<<<<<<<<<<
 *             a2_ptr += 1
 *         return s
 */
    __Pyx_TraceLine(1269,0,__PYX_ERR(0, 1269, __pyx_L1_error))
    __pyx_v_a1_ptr = (__pyx_v_a1_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1270
 *             s_ptr += 1
 *             a1_ptr += 1
 *             a2_ptr += 1             # <<<<<<<<<<<<<<
 *         return s
 * 
 */
    __Pyx_TraceLine(1270,0,__PYX_ERR(0, 1270, __pyx_L1_error))
    __pyx_v_a2_ptr = (__pyx_v_a2_ptr + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1271
 *             a1_ptr += 1
 *             a2_ptr += 1
 *         return s             # <<<<<<<<<<<<<<
 * 
 *     cdef np.ndarray __cal_qscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):
 */
  __Pyx_TraceLine(1271,0,__PYX_ERR(0, 1271, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_s));
  __pyx_r = ((PyArrayObject *)__pyx_v_s);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1248
 *         return True
 * 
 *     cdef np.ndarray __cal_pscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_pscore", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_s);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1273
 *         return s
 * 
 *     cdef np.ndarray __cal_qscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_qscore(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2) {
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_i;
  PyArrayObject *__pyx_v_s = 0;
  __pyx_t_5numpy_float32_t *__pyx_v_a1_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_a2_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_s_ptr;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array1;
  __Pyx_Buffer __pyx_pybuffer_array1;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array2;
  __Pyx_Buffer __pyx_pybuffer_array2;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_s;
  __Pyx_Buffer __pyx_pybuffer_s;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  npy_intp __pyx_t_10;
  npy_intp __pyx_t_11;
  __pyx_t_5numpy_int64_t __pyx_t_12;
  __pyx_t_5numpy_float32_t __pyx_t_13;
  __Pyx_RefNannySetupContext("__cal_qscore", 0);
  __Pyx_TraceCall("__cal_qscore", __pyx_f[0], 1273, 0, __PYX_ERR(0, 1273, __pyx_L1_error));
  __pyx_pybuffer_s.pybuffer.buf = NULL;
  __pyx_pybuffer_s.refcount = 0;
  __pyx_pybuffernd_s.data = NULL;
  __pyx_pybuffernd_s.rcbuffer = &__pyx_pybuffer_s;
  __pyx_pybuffer_array1.pybuffer.buf = NULL;
  __pyx_pybuffer_array1.refcount = 0;
  __pyx_pybuffernd_array1.data = NULL;
  __pyx_pybuffernd_array1.rcbuffer = &__pyx_pybuffer_array1;
  __pyx_pybuffer_array2.pybuffer.buf = NULL;
  __pyx_pybuffer_array2.refcount = 0;
  __pyx_pybuffernd_array2.data = NULL;
  __pyx_pybuffernd_array2.rcbuffer = &__pyx_pybuffer_array2;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array1.rcbuffer->pybuffer, (PyObject*)__pyx_v_array1, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1273, __pyx_L1_error)
  }
  __pyx_pybuffernd_array1.diminfo[0].strides = __pyx_pybuffernd_array1.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array1.diminfo[0].shape = __pyx_pybuffernd_array1.rcbuffer->pybuffer.shape[0];
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array2.rcbuffer->pybuffer, (PyObject*)__pyx_v_array2, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1273, __pyx_L1_error)
  }
  __pyx_pybuffernd_array2.diminfo[0].strides = __pyx_pybuffernd_array2.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array2.diminfo[0].shape = __pyx_pybuffernd_array2.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":1281
 *             float32_t * s_ptr
 * 
 *         assert array1.shape[0] == array2.shape[0]             # <<<<<<<<<<<<<<
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 */
  __Pyx_TraceLine(1281,0,__PYX_ERR(0, 1281, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(!(((__pyx_v_array1->dimensions[0]) == (__pyx_v_array2->dimensions[0])) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 1281, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1282
 * 
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")             # <<<<<<<<<<<<<<
 * 
 *         a1_ptr = <float32_t *> array1.data
 */
  __Pyx_TraceLine(1282,0,__PYX_ERR(0, 1282, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1282, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1282, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_array1->dimensions[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1282, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1282, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1282, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1282, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1282, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1282, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_v_s, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_s.diminfo[0].strides = __pyx_pybuffernd_s.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_s.diminfo[0].shape = __pyx_pybuffernd_s.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1282, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_s = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1284
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 *         a1_ptr = <float32_t *> array1.data             # <<<<<<<<<<<<<<
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data
 */
  __Pyx_TraceLine(1284,0,__PYX_ERR(0, 1284, __pyx_L1_error))
  __pyx_v_a1_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array1->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1285
 * 
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data             # <<<<<<<<<<<<<<
 *         s_ptr = <float32_t *> s.data
 * 
 */
  __Pyx_TraceLine(1285,0,__PYX_ERR(0, 1285, __pyx_L1_error))
  __pyx_v_a2_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array2->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1286
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data             # <<<<<<<<<<<<<<
 * 
 *         for i in range(array1.shape[0]):
 */
  __Pyx_TraceLine(1286,0,__PYX_ERR(0, 1286, __pyx_L1_error))
  __pyx_v_s_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_s->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1288
 *         s_ptr = <float32_t *> s.data
 * 
 *         for i in range(array1.shape[0]):             # <<<<<<<<<<<<<<
 *             #s_ptr[0] = self.pqtable[ get_pscore( int(a1_ptr[0]), a2_ptr[0] ) ]
 *             s_ptr[0] = self.pqtable[ get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] )) ]
 */
  __Pyx_TraceLine(1288,0,__PYX_ERR(0, 1288, __pyx_L1_error))
  __pyx_t_10 = (__pyx_v_array1->dimensions[0]);
  __pyx_t_11 = __pyx_t_10;
  for (__pyx_t_12 = 0; __pyx_t_12 < __pyx_t_11; __pyx_t_12+=1) {
    __pyx_v_i = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":1290
 *         for i in range(array1.shape[0]):
 *             #s_ptr[0] = self.pqtable[ get_pscore( int(a1_ptr[0]), a2_ptr[0] ) ]
 *             s_ptr[0] = self.pqtable[ get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] )) ]             # <<<<<<<<<<<<<<
 *             s_ptr += 1
 *             a1_ptr += 1
 */
    __Pyx_TraceLine(1290,0,__PYX_ERR(0, 1290, __pyx_L1_error))
    if (unlikely(__pyx_v_self->pqtable == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1290, __pyx_L1_error)
    }
    __pyx_t_4 = __Pyx_PyInt_From_npy_int32(((__pyx_t_5numpy_int32_t)(__pyx_v_a1_ptr[0]))); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1290, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_1 = PyFloat_FromDouble((__pyx_v_a2_ptr[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1290, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_3 = PyTuple_New(2); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1290, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_GIVEREF(__pyx_t_4);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_4);
    __Pyx_GIVEREF(__pyx_t_1);
    PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_1);
    __pyx_t_4 = 0;
    __pyx_t_1 = 0;
    __pyx_t_1 = PyFloat_FromDouble(__pyx_f_5MACS2_2IO_12CallPeakUnit_get_pscore(((PyObject*)__pyx_t_3))); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1290, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = __Pyx_PyDict_GetItem(__pyx_v_self->pqtable, __pyx_t_1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1290, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __pyx_t_13 = __pyx_PyFloat_AsFloat(__pyx_t_3); if (unlikely((__pyx_t_13 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1290, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    (__pyx_v_s_ptr[0]) = __pyx_t_13;

    /* "MACS2/IO/CallPeakUnit.pyx":1291
 *             #s_ptr[0] = self.pqtable[ get_pscore( int(a1_ptr[0]), a2_ptr[0] ) ]
 *             s_ptr[0] = self.pqtable[ get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] )) ]
 *             s_ptr += 1             # <<<<<<<<<<<<<<
 *             a1_ptr += 1
 *             a2_ptr += 1
 */
    __Pyx_TraceLine(1291,0,__PYX_ERR(0, 1291, __pyx_L1_error))
    __pyx_v_s_ptr = (__pyx_v_s_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1292
 *             s_ptr[0] = self.pqtable[ get_pscore(( <int32_t>(a1_ptr[0]), a2_ptr[0] )) ]
 *             s_ptr += 1
 *             a1_ptr += 1             # <<<<<<<<<<<<<<
 *             a2_ptr += 1
 *         return s
 */
    __Pyx_TraceLine(1292,0,__PYX_ERR(0, 1292, __pyx_L1_error))
    __pyx_v_a1_ptr = (__pyx_v_a1_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1293
 *             s_ptr += 1
 *             a1_ptr += 1
 *             a2_ptr += 1             # <<<<<<<<<<<<<<
 *         return s
 * 
 */
    __Pyx_TraceLine(1293,0,__PYX_ERR(0, 1293, __pyx_L1_error))
    __pyx_v_a2_ptr = (__pyx_v_a2_ptr + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1294
 *             a1_ptr += 1
 *             a2_ptr += 1
 *         return s             # <<<<<<<<<<<<<<
 * 
 *     cdef np.ndarray __cal_logLR ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):
 */
  __Pyx_TraceLine(1294,0,__PYX_ERR(0, 1294, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_s));
  __pyx_r = ((PyArrayObject *)__pyx_v_s);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1273
 *         return s
 * 
 *     cdef np.ndarray __cal_qscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_qscore", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_s);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1296
 *         return s
 * 
 *     cdef np.ndarray __cal_logLR ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_logLR(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2) {
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_i;
  PyArrayObject *__pyx_v_s = 0;
  __pyx_t_5numpy_float32_t *__pyx_v_a1_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_a2_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_s_ptr;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array1;
  __Pyx_Buffer __pyx_pybuffer_array1;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array2;
  __Pyx_Buffer __pyx_pybuffer_array2;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_s;
  __Pyx_Buffer __pyx_pybuffer_s;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  npy_intp __pyx_t_10;
  npy_intp __pyx_t_11;
  __pyx_t_5numpy_int64_t __pyx_t_12;
  __Pyx_RefNannySetupContext("__cal_logLR", 0);
  __Pyx_TraceCall("__cal_logLR", __pyx_f[0], 1296, 0, __PYX_ERR(0, 1296, __pyx_L1_error));
  __pyx_pybuffer_s.pybuffer.buf = NULL;
  __pyx_pybuffer_s.refcount = 0;
  __pyx_pybuffernd_s.data = NULL;
  __pyx_pybuffernd_s.rcbuffer = &__pyx_pybuffer_s;
  __pyx_pybuffer_array1.pybuffer.buf = NULL;
  __pyx_pybuffer_array1.refcount = 0;
  __pyx_pybuffernd_array1.data = NULL;
  __pyx_pybuffernd_array1.rcbuffer = &__pyx_pybuffer_array1;
  __pyx_pybuffer_array2.pybuffer.buf = NULL;
  __pyx_pybuffer_array2.refcount = 0;
  __pyx_pybuffernd_array2.data = NULL;
  __pyx_pybuffernd_array2.rcbuffer = &__pyx_pybuffer_array2;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array1.rcbuffer->pybuffer, (PyObject*)__pyx_v_array1, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1296, __pyx_L1_error)
  }
  __pyx_pybuffernd_array1.diminfo[0].strides = __pyx_pybuffernd_array1.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array1.diminfo[0].shape = __pyx_pybuffernd_array1.rcbuffer->pybuffer.shape[0];
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array2.rcbuffer->pybuffer, (PyObject*)__pyx_v_array2, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1296, __pyx_L1_error)
  }
  __pyx_pybuffernd_array2.diminfo[0].strides = __pyx_pybuffernd_array2.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array2.diminfo[0].shape = __pyx_pybuffernd_array2.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":1304
 *             float32_t * s_ptr
 * 
 *         assert array1.shape[0] == array2.shape[0]             # <<<<<<<<<<<<<<
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 */
  __Pyx_TraceLine(1304,0,__PYX_ERR(0, 1304, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(!(((__pyx_v_array1->dimensions[0]) == (__pyx_v_array2->dimensions[0])) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 1304, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1305
 * 
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")             # <<<<<<<<<<<<<<
 * 
 *         a1_ptr = <float32_t *> array1.data
 */
  __Pyx_TraceLine(1305,0,__PYX_ERR(0, 1305, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1305, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1305, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_array1->dimensions[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1305, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1305, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1305, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1305, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1305, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1305, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_v_s, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_s.diminfo[0].strides = __pyx_pybuffernd_s.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_s.diminfo[0].shape = __pyx_pybuffernd_s.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1305, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_s = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1307
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 *         a1_ptr = <float32_t *> array1.data             # <<<<<<<<<<<<<<
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data
 */
  __Pyx_TraceLine(1307,0,__PYX_ERR(0, 1307, __pyx_L1_error))
  __pyx_v_a1_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array1->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1308
 * 
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data             # <<<<<<<<<<<<<<
 *         s_ptr = <float32_t *> s.data
 * 
 */
  __Pyx_TraceLine(1308,0,__PYX_ERR(0, 1308, __pyx_L1_error))
  __pyx_v_a2_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array2->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1309
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data             # <<<<<<<<<<<<<<
 * 
 *         for i in range(array1.shape[0]):
 */
  __Pyx_TraceLine(1309,0,__PYX_ERR(0, 1309, __pyx_L1_error))
  __pyx_v_s_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_s->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1311
 *         s_ptr = <float32_t *> s.data
 * 
 *         for i in range(array1.shape[0]):             # <<<<<<<<<<<<<<
 *             s_ptr[0] = get_logLR_asym( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1
 */
  __Pyx_TraceLine(1311,0,__PYX_ERR(0, 1311, __pyx_L1_error))
  __pyx_t_10 = (__pyx_v_array1->dimensions[0]);
  __pyx_t_11 = __pyx_t_10;
  for (__pyx_t_12 = 0; __pyx_t_12 < __pyx_t_11; __pyx_t_12+=1) {
    __pyx_v_i = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":1312
 * 
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = get_logLR_asym( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )             # <<<<<<<<<<<<<<
 *             s_ptr += 1
 *             a1_ptr += 1
 */
    __Pyx_TraceLine(1312,0,__PYX_ERR(0, 1312, __pyx_L1_error))
    (__pyx_v_s_ptr[0]) = __pyx_f_5MACS2_2IO_12CallPeakUnit_get_logLR_asym(((__pyx_v_a1_ptr[0]) + __pyx_v_self->pseudocount), ((__pyx_v_a2_ptr[0]) + __pyx_v_self->pseudocount));

    /* "MACS2/IO/CallPeakUnit.pyx":1313
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = get_logLR_asym( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1             # <<<<<<<<<<<<<<
 *             a1_ptr += 1
 *             a2_ptr += 1
 */
    __Pyx_TraceLine(1313,0,__PYX_ERR(0, 1313, __pyx_L1_error))
    __pyx_v_s_ptr = (__pyx_v_s_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1314
 *             s_ptr[0] = get_logLR_asym( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1
 *             a1_ptr += 1             # <<<<<<<<<<<<<<
 *             a2_ptr += 1
 *         return s
 */
    __Pyx_TraceLine(1314,0,__PYX_ERR(0, 1314, __pyx_L1_error))
    __pyx_v_a1_ptr = (__pyx_v_a1_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1315
 *             s_ptr += 1
 *             a1_ptr += 1
 *             a2_ptr += 1             # <<<<<<<<<<<<<<
 *         return s
 * 
 */
    __Pyx_TraceLine(1315,0,__PYX_ERR(0, 1315, __pyx_L1_error))
    __pyx_v_a2_ptr = (__pyx_v_a2_ptr + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1316
 *             a1_ptr += 1
 *             a2_ptr += 1
 *         return s             # <<<<<<<<<<<<<<
 * 
 *     cdef np.ndarray __cal_logFE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):
 */
  __Pyx_TraceLine(1316,0,__PYX_ERR(0, 1316, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_s));
  __pyx_r = ((PyArrayObject *)__pyx_v_s);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1296
 *         return s
 * 
 *     cdef np.ndarray __cal_logLR ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_logLR", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_s);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1318
 *         return s
 * 
 *     cdef np.ndarray __cal_logFE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_logFE(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2) {
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_i;
  PyArrayObject *__pyx_v_s = 0;
  __pyx_t_5numpy_float32_t *__pyx_v_a1_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_a2_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_s_ptr;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array1;
  __Pyx_Buffer __pyx_pybuffer_array1;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array2;
  __Pyx_Buffer __pyx_pybuffer_array2;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_s;
  __Pyx_Buffer __pyx_pybuffer_s;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  npy_intp __pyx_t_10;
  npy_intp __pyx_t_11;
  __pyx_t_5numpy_int64_t __pyx_t_12;
  __Pyx_RefNannySetupContext("__cal_logFE", 0);
  __Pyx_TraceCall("__cal_logFE", __pyx_f[0], 1318, 0, __PYX_ERR(0, 1318, __pyx_L1_error));
  __pyx_pybuffer_s.pybuffer.buf = NULL;
  __pyx_pybuffer_s.refcount = 0;
  __pyx_pybuffernd_s.data = NULL;
  __pyx_pybuffernd_s.rcbuffer = &__pyx_pybuffer_s;
  __pyx_pybuffer_array1.pybuffer.buf = NULL;
  __pyx_pybuffer_array1.refcount = 0;
  __pyx_pybuffernd_array1.data = NULL;
  __pyx_pybuffernd_array1.rcbuffer = &__pyx_pybuffer_array1;
  __pyx_pybuffer_array2.pybuffer.buf = NULL;
  __pyx_pybuffer_array2.refcount = 0;
  __pyx_pybuffernd_array2.data = NULL;
  __pyx_pybuffernd_array2.rcbuffer = &__pyx_pybuffer_array2;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array1.rcbuffer->pybuffer, (PyObject*)__pyx_v_array1, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1318, __pyx_L1_error)
  }
  __pyx_pybuffernd_array1.diminfo[0].strides = __pyx_pybuffernd_array1.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array1.diminfo[0].shape = __pyx_pybuffernd_array1.rcbuffer->pybuffer.shape[0];
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array2.rcbuffer->pybuffer, (PyObject*)__pyx_v_array2, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1318, __pyx_L1_error)
  }
  __pyx_pybuffernd_array2.diminfo[0].strides = __pyx_pybuffernd_array2.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array2.diminfo[0].shape = __pyx_pybuffernd_array2.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":1326
 *             float32_t * s_ptr
 * 
 *         assert array1.shape[0] == array2.shape[0]             # <<<<<<<<<<<<<<
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 */
  __Pyx_TraceLine(1326,0,__PYX_ERR(0, 1326, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(!(((__pyx_v_array1->dimensions[0]) == (__pyx_v_array2->dimensions[0])) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 1326, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1327
 * 
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")             # <<<<<<<<<<<<<<
 * 
 *         a1_ptr = <float32_t *> array1.data
 */
  __Pyx_TraceLine(1327,0,__PYX_ERR(0, 1327, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1327, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1327, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_array1->dimensions[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1327, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1327, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1327, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1327, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1327, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1327, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_v_s, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_s.diminfo[0].strides = __pyx_pybuffernd_s.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_s.diminfo[0].shape = __pyx_pybuffernd_s.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1327, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_s = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1329
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 *         a1_ptr = <float32_t *> array1.data             # <<<<<<<<<<<<<<
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data
 */
  __Pyx_TraceLine(1329,0,__PYX_ERR(0, 1329, __pyx_L1_error))
  __pyx_v_a1_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array1->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1330
 * 
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data             # <<<<<<<<<<<<<<
 *         s_ptr = <float32_t *> s.data
 * 
 */
  __Pyx_TraceLine(1330,0,__PYX_ERR(0, 1330, __pyx_L1_error))
  __pyx_v_a2_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array2->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1331
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data             # <<<<<<<<<<<<<<
 * 
 *         for i in range(array1.shape[0]):
 */
  __Pyx_TraceLine(1331,0,__PYX_ERR(0, 1331, __pyx_L1_error))
  __pyx_v_s_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_s->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1333
 *         s_ptr = <float32_t *> s.data
 * 
 *         for i in range(array1.shape[0]):             # <<<<<<<<<<<<<<
 *             s_ptr[0] = get_logFE( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1
 */
  __Pyx_TraceLine(1333,0,__PYX_ERR(0, 1333, __pyx_L1_error))
  __pyx_t_10 = (__pyx_v_array1->dimensions[0]);
  __pyx_t_11 = __pyx_t_10;
  for (__pyx_t_12 = 0; __pyx_t_12 < __pyx_t_11; __pyx_t_12+=1) {
    __pyx_v_i = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":1334
 * 
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = get_logFE( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )             # <<<<<<<<<<<<<<
 *             s_ptr += 1
 *             a1_ptr += 1
 */
    __Pyx_TraceLine(1334,0,__PYX_ERR(0, 1334, __pyx_L1_error))
    (__pyx_v_s_ptr[0]) = __pyx_f_5MACS2_2IO_12CallPeakUnit_get_logFE(((__pyx_v_a1_ptr[0]) + __pyx_v_self->pseudocount), ((__pyx_v_a2_ptr[0]) + __pyx_v_self->pseudocount));

    /* "MACS2/IO/CallPeakUnit.pyx":1335
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = get_logFE( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1             # <<<<<<<<<<<<<<
 *             a1_ptr += 1
 *             a2_ptr += 1
 */
    __Pyx_TraceLine(1335,0,__PYX_ERR(0, 1335, __pyx_L1_error))
    __pyx_v_s_ptr = (__pyx_v_s_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1336
 *             s_ptr[0] = get_logFE( a1_ptr[0] + self.pseudocount, a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1
 *             a1_ptr += 1             # <<<<<<<<<<<<<<
 *             a2_ptr += 1
 *         return s
 */
    __Pyx_TraceLine(1336,0,__PYX_ERR(0, 1336, __pyx_L1_error))
    __pyx_v_a1_ptr = (__pyx_v_a1_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1337
 *             s_ptr += 1
 *             a1_ptr += 1
 *             a2_ptr += 1             # <<<<<<<<<<<<<<
 *         return s
 * 
 */
    __Pyx_TraceLine(1337,0,__PYX_ERR(0, 1337, __pyx_L1_error))
    __pyx_v_a2_ptr = (__pyx_v_a2_ptr + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1338
 *             a1_ptr += 1
 *             a2_ptr += 1
 *         return s             # <<<<<<<<<<<<<<
 * 
 *     cdef np.ndarray __cal_FE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):
 */
  __Pyx_TraceLine(1338,0,__PYX_ERR(0, 1338, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_s));
  __pyx_r = ((PyArrayObject *)__pyx_v_s);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1318
 *         return s
 * 
 *     cdef np.ndarray __cal_logFE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_logFE", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_s);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1340
 *         return s
 * 
 *     cdef np.ndarray __cal_FE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_FE(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2) {
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_i;
  PyArrayObject *__pyx_v_s = 0;
  __pyx_t_5numpy_float32_t *__pyx_v_a1_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_a2_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_s_ptr;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array1;
  __Pyx_Buffer __pyx_pybuffer_array1;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array2;
  __Pyx_Buffer __pyx_pybuffer_array2;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_s;
  __Pyx_Buffer __pyx_pybuffer_s;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  npy_intp __pyx_t_10;
  npy_intp __pyx_t_11;
  __pyx_t_5numpy_int64_t __pyx_t_12;
  __pyx_t_5numpy_float64_t __pyx_t_13;
  __pyx_t_5numpy_float64_t __pyx_t_14;
  __Pyx_RefNannySetupContext("__cal_FE", 0);
  __Pyx_TraceCall("__cal_FE", __pyx_f[0], 1340, 0, __PYX_ERR(0, 1340, __pyx_L1_error));
  __pyx_pybuffer_s.pybuffer.buf = NULL;
  __pyx_pybuffer_s.refcount = 0;
  __pyx_pybuffernd_s.data = NULL;
  __pyx_pybuffernd_s.rcbuffer = &__pyx_pybuffer_s;
  __pyx_pybuffer_array1.pybuffer.buf = NULL;
  __pyx_pybuffer_array1.refcount = 0;
  __pyx_pybuffernd_array1.data = NULL;
  __pyx_pybuffernd_array1.rcbuffer = &__pyx_pybuffer_array1;
  __pyx_pybuffer_array2.pybuffer.buf = NULL;
  __pyx_pybuffer_array2.refcount = 0;
  __pyx_pybuffernd_array2.data = NULL;
  __pyx_pybuffernd_array2.rcbuffer = &__pyx_pybuffer_array2;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array1.rcbuffer->pybuffer, (PyObject*)__pyx_v_array1, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1340, __pyx_L1_error)
  }
  __pyx_pybuffernd_array1.diminfo[0].strides = __pyx_pybuffernd_array1.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array1.diminfo[0].shape = __pyx_pybuffernd_array1.rcbuffer->pybuffer.shape[0];
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array2.rcbuffer->pybuffer, (PyObject*)__pyx_v_array2, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1340, __pyx_L1_error)
  }
  __pyx_pybuffernd_array2.diminfo[0].strides = __pyx_pybuffernd_array2.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array2.diminfo[0].shape = __pyx_pybuffernd_array2.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":1348
 *             float32_t * s_ptr
 * 
 *         assert array1.shape[0] == array2.shape[0]             # <<<<<<<<<<<<<<
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 */
  __Pyx_TraceLine(1348,0,__PYX_ERR(0, 1348, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(!(((__pyx_v_array1->dimensions[0]) == (__pyx_v_array2->dimensions[0])) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 1348, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1349
 * 
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")             # <<<<<<<<<<<<<<
 * 
 *         a1_ptr = <float32_t *> array1.data
 */
  __Pyx_TraceLine(1349,0,__PYX_ERR(0, 1349, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_array1->dimensions[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1349, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1349, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1349, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_v_s, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_s.diminfo[0].strides = __pyx_pybuffernd_s.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_s.diminfo[0].shape = __pyx_pybuffernd_s.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1349, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_s = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1351
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 *         a1_ptr = <float32_t *> array1.data             # <<<<<<<<<<<<<<
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data
 */
  __Pyx_TraceLine(1351,0,__PYX_ERR(0, 1351, __pyx_L1_error))
  __pyx_v_a1_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array1->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1352
 * 
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data             # <<<<<<<<<<<<<<
 *         s_ptr = <float32_t *> s.data
 * 
 */
  __Pyx_TraceLine(1352,0,__PYX_ERR(0, 1352, __pyx_L1_error))
  __pyx_v_a2_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array2->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1353
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data             # <<<<<<<<<<<<<<
 * 
 *         for i in range(array1.shape[0]):
 */
  __Pyx_TraceLine(1353,0,__PYX_ERR(0, 1353, __pyx_L1_error))
  __pyx_v_s_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_s->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1355
 *         s_ptr = <float32_t *> s.data
 * 
 *         for i in range(array1.shape[0]):             # <<<<<<<<<<<<<<
 *             s_ptr[0] = (a1_ptr[0] + self.pseudocount) / ( a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1
 */
  __Pyx_TraceLine(1355,0,__PYX_ERR(0, 1355, __pyx_L1_error))
  __pyx_t_10 = (__pyx_v_array1->dimensions[0]);
  __pyx_t_11 = __pyx_t_10;
  for (__pyx_t_12 = 0; __pyx_t_12 < __pyx_t_11; __pyx_t_12+=1) {
    __pyx_v_i = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":1356
 * 
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = (a1_ptr[0] + self.pseudocount) / ( a2_ptr[0] + self.pseudocount )             # <<<<<<<<<<<<<<
 *             s_ptr += 1
 *             a1_ptr += 1
 */
    __Pyx_TraceLine(1356,0,__PYX_ERR(0, 1356, __pyx_L1_error))
    __pyx_t_13 = ((__pyx_v_a1_ptr[0]) + __pyx_v_self->pseudocount);
    __pyx_t_14 = ((__pyx_v_a2_ptr[0]) + __pyx_v_self->pseudocount);
    if (unlikely(__pyx_t_14 == 0)) {
      PyErr_SetString(PyExc_ZeroDivisionError, "float division");
      __PYX_ERR(0, 1356, __pyx_L1_error)
    }
    (__pyx_v_s_ptr[0]) = (__pyx_t_13 / __pyx_t_14);

    /* "MACS2/IO/CallPeakUnit.pyx":1357
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = (a1_ptr[0] + self.pseudocount) / ( a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1             # <<<<<<<<<<<<<<
 *             a1_ptr += 1
 *             a2_ptr += 1
 */
    __Pyx_TraceLine(1357,0,__PYX_ERR(0, 1357, __pyx_L1_error))
    __pyx_v_s_ptr = (__pyx_v_s_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1358
 *             s_ptr[0] = (a1_ptr[0] + self.pseudocount) / ( a2_ptr[0] + self.pseudocount )
 *             s_ptr += 1
 *             a1_ptr += 1             # <<<<<<<<<<<<<<
 *             a2_ptr += 1
 *         return s
 */
    __Pyx_TraceLine(1358,0,__PYX_ERR(0, 1358, __pyx_L1_error))
    __pyx_v_a1_ptr = (__pyx_v_a1_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1359
 *             s_ptr += 1
 *             a1_ptr += 1
 *             a2_ptr += 1             # <<<<<<<<<<<<<<
 *         return s
 * 
 */
    __Pyx_TraceLine(1359,0,__PYX_ERR(0, 1359, __pyx_L1_error))
    __pyx_v_a2_ptr = (__pyx_v_a2_ptr + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1360
 *             a1_ptr += 1
 *             a2_ptr += 1
 *         return s             # <<<<<<<<<<<<<<
 * 
 *     cdef np.ndarray __cal_subtraction ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):
 */
  __Pyx_TraceLine(1360,0,__PYX_ERR(0, 1360, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_s));
  __pyx_r = ((PyArrayObject *)__pyx_v_s);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1340
 *         return s
 * 
 *     cdef np.ndarray __cal_FE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_FE", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_s);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1362
 *         return s
 * 
 *     cdef np.ndarray __cal_subtraction ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

static PyArrayObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_subtraction(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyArrayObject *__pyx_v_array1, PyArrayObject *__pyx_v_array2) {
  CYTHON_UNUSED __pyx_t_5numpy_int64_t __pyx_v_i;
  PyArrayObject *__pyx_v_s = 0;
  __pyx_t_5numpy_float32_t *__pyx_v_a1_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_a2_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_s_ptr;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array1;
  __Pyx_Buffer __pyx_pybuffer_array1;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_array2;
  __Pyx_Buffer __pyx_pybuffer_array2;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_s;
  __Pyx_Buffer __pyx_pybuffer_s;
  PyArrayObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  npy_intp __pyx_t_10;
  npy_intp __pyx_t_11;
  __pyx_t_5numpy_int64_t __pyx_t_12;
  __Pyx_RefNannySetupContext("__cal_subtraction", 0);
  __Pyx_TraceCall("__cal_subtraction", __pyx_f[0], 1362, 0, __PYX_ERR(0, 1362, __pyx_L1_error));
  __pyx_pybuffer_s.pybuffer.buf = NULL;
  __pyx_pybuffer_s.refcount = 0;
  __pyx_pybuffernd_s.data = NULL;
  __pyx_pybuffernd_s.rcbuffer = &__pyx_pybuffer_s;
  __pyx_pybuffer_array1.pybuffer.buf = NULL;
  __pyx_pybuffer_array1.refcount = 0;
  __pyx_pybuffernd_array1.data = NULL;
  __pyx_pybuffernd_array1.rcbuffer = &__pyx_pybuffer_array1;
  __pyx_pybuffer_array2.pybuffer.buf = NULL;
  __pyx_pybuffer_array2.refcount = 0;
  __pyx_pybuffernd_array2.data = NULL;
  __pyx_pybuffernd_array2.rcbuffer = &__pyx_pybuffer_array2;
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array1.rcbuffer->pybuffer, (PyObject*)__pyx_v_array1, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1362, __pyx_L1_error)
  }
  __pyx_pybuffernd_array1.diminfo[0].strides = __pyx_pybuffernd_array1.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array1.diminfo[0].shape = __pyx_pybuffernd_array1.rcbuffer->pybuffer.shape[0];
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_array2.rcbuffer->pybuffer, (PyObject*)__pyx_v_array2, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) __PYX_ERR(0, 1362, __pyx_L1_error)
  }
  __pyx_pybuffernd_array2.diminfo[0].strides = __pyx_pybuffernd_array2.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_array2.diminfo[0].shape = __pyx_pybuffernd_array2.rcbuffer->pybuffer.shape[0];

  /* "MACS2/IO/CallPeakUnit.pyx":1370
 *             float32_t * s_ptr
 * 
 *         assert array1.shape[0] == array2.shape[0]             # <<<<<<<<<<<<<<
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 */
  __Pyx_TraceLine(1370,0,__PYX_ERR(0, 1370, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(!(((__pyx_v_array1->dimensions[0]) == (__pyx_v_array2->dimensions[0])) != 0))) {
      PyErr_SetNone(PyExc_AssertionError);
      __PYX_ERR(0, 1370, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1371
 * 
 *         assert array1.shape[0] == array2.shape[0]
 *         s = np.zeros(array1.shape[0], dtype="float32")             # <<<<<<<<<<<<<<
 * 
 *         a1_ptr = <float32_t *> array1.data
 */
  __Pyx_TraceLine(1371,0,__PYX_ERR(0, 1371, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_1, __pyx_n_s_np); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1371, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_1, __pyx_n_s_zeros); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1371, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_array1->dimensions[0])); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1371, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1371, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_GIVEREF(__pyx_t_1);
  PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_t_1);
  __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1371, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_t_1, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1371, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_2, __pyx_t_3, __pyx_t_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1371, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1371, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_s.rcbuffer->pybuffer, (PyObject*)__pyx_v_s, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_s.diminfo[0].strides = __pyx_pybuffernd_s.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_s.diminfo[0].shape = __pyx_pybuffernd_s.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1371, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_s = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1373
 *         s = np.zeros(array1.shape[0], dtype="float32")
 * 
 *         a1_ptr = <float32_t *> array1.data             # <<<<<<<<<<<<<<
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data
 */
  __Pyx_TraceLine(1373,0,__PYX_ERR(0, 1373, __pyx_L1_error))
  __pyx_v_a1_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array1->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1374
 * 
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data             # <<<<<<<<<<<<<<
 *         s_ptr = <float32_t *> s.data
 * 
 */
  __Pyx_TraceLine(1374,0,__PYX_ERR(0, 1374, __pyx_L1_error))
  __pyx_v_a2_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_array2->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1375
 *         a1_ptr = <float32_t *> array1.data
 *         a2_ptr = <float32_t *> array2.data
 *         s_ptr = <float32_t *> s.data             # <<<<<<<<<<<<<<
 * 
 *         for i in range(array1.shape[0]):
 */
  __Pyx_TraceLine(1375,0,__PYX_ERR(0, 1375, __pyx_L1_error))
  __pyx_v_s_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_s->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1377
 *         s_ptr = <float32_t *> s.data
 * 
 *         for i in range(array1.shape[0]):             # <<<<<<<<<<<<<<
 *             s_ptr[0] = a1_ptr[0] - a2_ptr[0]
 *             s_ptr += 1
 */
  __Pyx_TraceLine(1377,0,__PYX_ERR(0, 1377, __pyx_L1_error))
  __pyx_t_10 = (__pyx_v_array1->dimensions[0]);
  __pyx_t_11 = __pyx_t_10;
  for (__pyx_t_12 = 0; __pyx_t_12 < __pyx_t_11; __pyx_t_12+=1) {
    __pyx_v_i = __pyx_t_12;

    /* "MACS2/IO/CallPeakUnit.pyx":1378
 * 
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = a1_ptr[0] - a2_ptr[0]             # <<<<<<<<<<<<<<
 *             s_ptr += 1
 *             a1_ptr += 1
 */
    __Pyx_TraceLine(1378,0,__PYX_ERR(0, 1378, __pyx_L1_error))
    (__pyx_v_s_ptr[0]) = ((__pyx_v_a1_ptr[0]) - (__pyx_v_a2_ptr[0]));

    /* "MACS2/IO/CallPeakUnit.pyx":1379
 *         for i in range(array1.shape[0]):
 *             s_ptr[0] = a1_ptr[0] - a2_ptr[0]
 *             s_ptr += 1             # <<<<<<<<<<<<<<
 *             a1_ptr += 1
 *             a2_ptr += 1
 */
    __Pyx_TraceLine(1379,0,__PYX_ERR(0, 1379, __pyx_L1_error))
    __pyx_v_s_ptr = (__pyx_v_s_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1380
 *             s_ptr[0] = a1_ptr[0] - a2_ptr[0]
 *             s_ptr += 1
 *             a1_ptr += 1             # <<<<<<<<<<<<<<
 *             a2_ptr += 1
 *         return s
 */
    __Pyx_TraceLine(1380,0,__PYX_ERR(0, 1380, __pyx_L1_error))
    __pyx_v_a1_ptr = (__pyx_v_a1_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1381
 *             s_ptr += 1
 *             a1_ptr += 1
 *             a2_ptr += 1             # <<<<<<<<<<<<<<
 *         return s
 * 
 */
    __Pyx_TraceLine(1381,0,__PYX_ERR(0, 1381, __pyx_L1_error))
    __pyx_v_a2_ptr = (__pyx_v_a2_ptr + 1);
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1382
 *             a1_ptr += 1
 *             a2_ptr += 1
 *         return s             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_TraceLine(1382,0,__PYX_ERR(0, 1382, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(((PyObject *)__pyx_v_s));
  __pyx_r = ((PyArrayObject *)__pyx_v_s);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1362
 *         return s
 * 
 *     cdef np.ndarray __cal_subtraction ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__cal_subtraction", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array1.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_array2.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_s.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_s);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1385
 * 
 * 
 *     cdef bool __write_bedGraph_for_a_chromosome ( self, bytes chrom ):             # <<<<<<<<<<<<<<
 *         """Write treat/control values for a certain chromosome into a
 *         specified file handler.
 */

static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___write_bedGraph_for_a_chromosome(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_chrom) {
  PyArrayObject *__pyx_v_pos_array = 0;
  PyArrayObject *__pyx_v_treat_array = 0;
  PyArrayObject *__pyx_v_ctrl_array = 0;
  __pyx_t_5numpy_int32_t *__pyx_v_pos_array_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_treat_array_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_ctrl_array_ptr;
  __pyx_t_5numpy_int32_t __pyx_v_l;
  CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_int32_t __pyx_v_p;
  __pyx_t_5numpy_int32_t __pyx_v_pre_p_t;
  __pyx_t_5numpy_int32_t __pyx_v_pre_p_c;
  __pyx_t_5numpy_float32_t __pyx_v_pre_v_t;
  __pyx_t_5numpy_float32_t __pyx_v_pre_v_c;
  __pyx_t_5numpy_float32_t __pyx_v_v_t;
  __pyx_t_5numpy_float32_t __pyx_v_v_c;
  __pyx_t_5numpy_float32_t __pyx_v_denominator;
  FILE *__pyx_v_ft;
  FILE *__pyx_v_fc;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_ctrl_array;
  __Pyx_Buffer __pyx_pybuffer_ctrl_array;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_pos_array;
  __Pyx_Buffer __pyx_pybuffer_pos_array;
  __Pyx_LocalBuf_ND __pyx_pybuffernd_treat_array;
  __Pyx_Buffer __pyx_pybuffer_treat_array;
  PyBoolObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyArrayObject *__pyx_t_5 = NULL;
  int __pyx_t_6;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  PyArrayObject *__pyx_t_10 = NULL;
  int __pyx_t_11;
  __pyx_t_5numpy_float32_t __pyx_t_12;
  FILE *__pyx_t_13;
  __pyx_t_5numpy_int32_t __pyx_t_14;
  __pyx_t_5numpy_int32_t __pyx_t_15;
  __pyx_t_5numpy_int32_t __pyx_t_16;
  char *__pyx_t_17;
  __Pyx_RefNannySetupContext("__write_bedGraph_for_a_chromosome", 0);
  __Pyx_TraceCall("__write_bedGraph_for_a_chromosome", __pyx_f[0], 1385, 0, __PYX_ERR(0, 1385, __pyx_L1_error));
  __pyx_pybuffer_pos_array.pybuffer.buf = NULL;
  __pyx_pybuffer_pos_array.refcount = 0;
  __pyx_pybuffernd_pos_array.data = NULL;
  __pyx_pybuffernd_pos_array.rcbuffer = &__pyx_pybuffer_pos_array;
  __pyx_pybuffer_treat_array.pybuffer.buf = NULL;
  __pyx_pybuffer_treat_array.refcount = 0;
  __pyx_pybuffernd_treat_array.data = NULL;
  __pyx_pybuffernd_treat_array.rcbuffer = &__pyx_pybuffer_treat_array;
  __pyx_pybuffer_ctrl_array.pybuffer.buf = NULL;
  __pyx_pybuffer_ctrl_array.refcount = 0;
  __pyx_pybuffernd_ctrl_array.data = NULL;
  __pyx_pybuffernd_ctrl_array.rcbuffer = &__pyx_pybuffer_ctrl_array;

  /* "MACS2/IO/CallPeakUnit.pyx":1404
 *             basestring tmp_bytes
 * 
 *         [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl             # <<<<<<<<<<<<<<
 *         pos_array_ptr = <int32_t *> pos_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 */
  __Pyx_TraceLine(1404,0,__PYX_ERR(0, 1404, __pyx_L1_error))
  __pyx_t_1 = __pyx_v_self->chr_pos_treat_ctrl;
  __Pyx_INCREF(__pyx_t_1);
  if (likely(__pyx_t_1 != Py_None)) {
    PyObject* sequence = __pyx_t_1;
    Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
    if (unlikely(size != 3)) {
      if (size > 3) __Pyx_RaiseTooManyValuesError(3);
      else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
      __PYX_ERR(0, 1404, __pyx_L1_error)
    }
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_2 = PyList_GET_ITEM(sequence, 0); 
    __pyx_t_3 = PyList_GET_ITEM(sequence, 1); 
    __pyx_t_4 = PyList_GET_ITEM(sequence, 2); 
    __Pyx_INCREF(__pyx_t_2);
    __Pyx_INCREF(__pyx_t_3);
    __Pyx_INCREF(__pyx_t_4);
    #else
    __pyx_t_2 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1404, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_3 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1404, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_4 = PySequence_ITEM(sequence, 2); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1404, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    #endif
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  } else {
    __Pyx_RaiseNoneNotIterableError(); __PYX_ERR(0, 1404, __pyx_L1_error)
  }
  if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1404, __pyx_L1_error)
  if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1404, __pyx_L1_error)
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1404, __pyx_L1_error)
  __pyx_t_5 = ((PyArrayObject *)__pyx_t_2);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer, (PyObject*)__pyx_t_5, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer, (PyObject*)__pyx_v_pos_array, &__Pyx_TypeInfo_nn___pyx_t_5numpy_int32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_pos_array.diminfo[0].strides = __pyx_pybuffernd_pos_array.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_pos_array.diminfo[0].shape = __pyx_pybuffernd_pos_array.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1404, __pyx_L1_error)
  }
  __pyx_t_5 = 0;
  __pyx_v_pos_array = ((PyArrayObject *)__pyx_t_2);
  __pyx_t_2 = 0;
  __pyx_t_10 = ((PyArrayObject *)__pyx_t_3);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer, (PyObject*)__pyx_t_10, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_9, &__pyx_t_8, &__pyx_t_7);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer, (PyObject*)__pyx_v_treat_array, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_9); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_7);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_9, __pyx_t_8, __pyx_t_7);
      }
      __pyx_t_9 = __pyx_t_8 = __pyx_t_7 = 0;
    }
    __pyx_pybuffernd_treat_array.diminfo[0].strides = __pyx_pybuffernd_treat_array.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_treat_array.diminfo[0].shape = __pyx_pybuffernd_treat_array.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1404, __pyx_L1_error)
  }
  __pyx_t_10 = 0;
  __pyx_v_treat_array = ((PyArrayObject *)__pyx_t_3);
  __pyx_t_3 = 0;
  __pyx_t_10 = ((PyArrayObject *)__pyx_t_4);
  {
    __Pyx_BufFmt_StackElem __pyx_stack[1];
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer);
    __pyx_t_6 = __Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer, (PyObject*)__pyx_t_10, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack);
    if (unlikely(__pyx_t_6 < 0)) {
      PyErr_Fetch(&__pyx_t_7, &__pyx_t_8, &__pyx_t_9);
      if (unlikely(__Pyx_GetBufferAndValidate(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer, (PyObject*)__pyx_v_ctrl_array, &__Pyx_TypeInfo_nn___pyx_t_5numpy_float32_t, PyBUF_FORMAT| PyBUF_STRIDES, 1, 0, __pyx_stack) == -1)) {
        Py_XDECREF(__pyx_t_7); Py_XDECREF(__pyx_t_8); Py_XDECREF(__pyx_t_9);
        __Pyx_RaiseBufferFallbackError();
      } else {
        PyErr_Restore(__pyx_t_7, __pyx_t_8, __pyx_t_9);
      }
      __pyx_t_7 = __pyx_t_8 = __pyx_t_9 = 0;
    }
    __pyx_pybuffernd_ctrl_array.diminfo[0].strides = __pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer.strides[0]; __pyx_pybuffernd_ctrl_array.diminfo[0].shape = __pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer.shape[0];
    if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(0, 1404, __pyx_L1_error)
  }
  __pyx_t_10 = 0;
  __pyx_v_ctrl_array = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1405
 * 
 *         [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 *         pos_array_ptr = <int32_t *> pos_array.data             # <<<<<<<<<<<<<<
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 */
  __Pyx_TraceLine(1405,0,__PYX_ERR(0, 1405, __pyx_L1_error))
  __pyx_v_pos_array_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_pos_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1406
 *         [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 *         pos_array_ptr = <int32_t *> pos_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data             # <<<<<<<<<<<<<<
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 */
  __Pyx_TraceLine(1406,0,__PYX_ERR(0, 1406, __pyx_L1_error))
  __pyx_v_treat_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_treat_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1407
 *         pos_array_ptr = <int32_t *> pos_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data             # <<<<<<<<<<<<<<
 * 
 *         if self.save_SPMR:
 */
  __Pyx_TraceLine(1407,0,__PYX_ERR(0, 1407, __pyx_L1_error))
  __pyx_v_ctrl_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_ctrl_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1409
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 *         if self.save_SPMR:             # <<<<<<<<<<<<<<
 *             if self.treat_scaling_factor == 1:
 *                 # in this case, control has been asked to be scaled to depth of treatment
 */
  __Pyx_TraceLine(1409,0,__PYX_ERR(0, 1409, __pyx_L1_error))
  __pyx_t_11 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->save_SPMR)); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1409, __pyx_L1_error)
  if (__pyx_t_11) {

    /* "MACS2/IO/CallPeakUnit.pyx":1410
 * 
 *         if self.save_SPMR:
 *             if self.treat_scaling_factor == 1:             # <<<<<<<<<<<<<<
 *                 # in this case, control has been asked to be scaled to depth of treatment
 *                 denominator  = self.treat.total/1e6
 */
    __Pyx_TraceLine(1410,0,__PYX_ERR(0, 1410, __pyx_L1_error))
    __pyx_t_11 = ((__pyx_v_self->treat_scaling_factor == 1.0) != 0);
    if (__pyx_t_11) {

      /* "MACS2/IO/CallPeakUnit.pyx":1412
 *             if self.treat_scaling_factor == 1:
 *                 # in this case, control has been asked to be scaled to depth of treatment
 *                 denominator  = self.treat.total/1e6             # <<<<<<<<<<<<<<
 *             else:
 *                 # in this case, treatment has been asked to be scaled to depth of control
 */
      __Pyx_TraceLine(1412,0,__PYX_ERR(0, 1412, __pyx_L1_error))
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_total); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1412, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_4 = __Pyx_PyFloat_TrueDivideObjC(__pyx_t_1, __pyx_float_1e6, 1e6, 0, 0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1412, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_12 = __pyx_PyFloat_AsFloat(__pyx_t_4); if (unlikely((__pyx_t_12 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1412, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_v_denominator = __pyx_t_12;

      /* "MACS2/IO/CallPeakUnit.pyx":1410
 * 
 *         if self.save_SPMR:
 *             if self.treat_scaling_factor == 1:             # <<<<<<<<<<<<<<
 *                 # in this case, control has been asked to be scaled to depth of treatment
 *                 denominator  = self.treat.total/1e6
 */
      goto __pyx_L4;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1415
 *             else:
 *                 # in this case, treatment has been asked to be scaled to depth of control
 *                 denominator  = self.ctrl.total/1e6             # <<<<<<<<<<<<<<
 *         else:
 *             denominator = 1.0
 */
    __Pyx_TraceLine(1415,0,__PYX_ERR(0, 1415, __pyx_L1_error))
    /*else*/ {
      __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->ctrl, __pyx_n_s_total); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1415, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_1 = __Pyx_PyFloat_TrueDivideObjC(__pyx_t_4, __pyx_float_1e6, 1e6, 0, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1415, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_12 = __pyx_PyFloat_AsFloat(__pyx_t_1); if (unlikely((__pyx_t_12 == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1415, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_v_denominator = __pyx_t_12;
    }
    __pyx_L4:;

    /* "MACS2/IO/CallPeakUnit.pyx":1409
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 *         if self.save_SPMR:             # <<<<<<<<<<<<<<
 *             if self.treat_scaling_factor == 1:
 *                 # in this case, control has been asked to be scaled to depth of treatment
 */
    goto __pyx_L3;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1417
 *                 denominator  = self.ctrl.total/1e6
 *         else:
 *             denominator = 1.0             # <<<<<<<<<<<<<<
 * 
 *         l = pos_array.shape[ 0 ]
 */
  __Pyx_TraceLine(1417,0,__PYX_ERR(0, 1417, __pyx_L1_error))
  /*else*/ {
    __pyx_v_denominator = 1.0;
  }
  __pyx_L3:;

  /* "MACS2/IO/CallPeakUnit.pyx":1419
 *             denominator = 1.0
 * 
 *         l = pos_array.shape[ 0 ]             # <<<<<<<<<<<<<<
 * 
 *         if l == 0:              # if there is no data, return
 */
  __Pyx_TraceLine(1419,0,__PYX_ERR(0, 1419, __pyx_L1_error))
  __pyx_v_l = (__pyx_v_pos_array->dimensions[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1421
 *         l = pos_array.shape[ 0 ]
 * 
 *         if l == 0:              # if there is no data, return             # <<<<<<<<<<<<<<
 *             return False
 * 
 */
  __Pyx_TraceLine(1421,0,__PYX_ERR(0, 1421, __pyx_L1_error))
  __pyx_t_11 = ((__pyx_v_l == 0) != 0);
  if (__pyx_t_11) {

    /* "MACS2/IO/CallPeakUnit.pyx":1422
 * 
 *         if l == 0:              # if there is no data, return
 *             return False             # <<<<<<<<<<<<<<
 * 
 *         ft = self.bedGraph_treat_f
 */
    __Pyx_TraceLine(1422,0,__PYX_ERR(0, 1422, __pyx_L1_error))
    __Pyx_XDECREF(((PyObject *)__pyx_r));
    __Pyx_INCREF(Py_False);
    __pyx_r = ((PyBoolObject *)Py_False);
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1421
 *         l = pos_array.shape[ 0 ]
 * 
 *         if l == 0:              # if there is no data, return             # <<<<<<<<<<<<<<
 *             return False
 * 
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1424
 *             return False
 * 
 *         ft = self.bedGraph_treat_f             # <<<<<<<<<<<<<<
 *         fc = self.bedGraph_ctrl_f
 *         #t_write_func = self.bedGraph_treat.write
 */
  __Pyx_TraceLine(1424,0,__PYX_ERR(0, 1424, __pyx_L1_error))
  __pyx_t_13 = __pyx_v_self->bedGraph_treat_f;
  __pyx_v_ft = __pyx_t_13;

  /* "MACS2/IO/CallPeakUnit.pyx":1425
 * 
 *         ft = self.bedGraph_treat_f
 *         fc = self.bedGraph_ctrl_f             # <<<<<<<<<<<<<<
 *         #t_write_func = self.bedGraph_treat.write
 *         #c_write_func = self.bedGraph_ctrl.write
 */
  __Pyx_TraceLine(1425,0,__PYX_ERR(0, 1425, __pyx_L1_error))
  __pyx_t_13 = __pyx_v_self->bedGraph_ctrl_f;
  __pyx_v_fc = __pyx_t_13;

  /* "MACS2/IO/CallPeakUnit.pyx":1429
 *         #c_write_func = self.bedGraph_ctrl.write
 * 
 *         pre_p_t = 0             # <<<<<<<<<<<<<<
 *         pre_p_c = 0
 *         pre_v_t = treat_array_ptr[ 0 ]/denominator
 */
  __Pyx_TraceLine(1429,0,__PYX_ERR(0, 1429, __pyx_L1_error))
  __pyx_v_pre_p_t = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1430
 * 
 *         pre_p_t = 0
 *         pre_p_c = 0             # <<<<<<<<<<<<<<
 *         pre_v_t = treat_array_ptr[ 0 ]/denominator
 *         pre_v_c = ctrl_array_ptr [ 0 ]/denominator
 */
  __Pyx_TraceLine(1430,0,__PYX_ERR(0, 1430, __pyx_L1_error))
  __pyx_v_pre_p_c = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1431
 *         pre_p_t = 0
 *         pre_p_c = 0
 *         pre_v_t = treat_array_ptr[ 0 ]/denominator             # <<<<<<<<<<<<<<
 *         pre_v_c = ctrl_array_ptr [ 0 ]/denominator
 *         treat_array_ptr += 1
 */
  __Pyx_TraceLine(1431,0,__PYX_ERR(0, 1431, __pyx_L1_error))
  if (unlikely(__pyx_v_denominator == 0)) {
    PyErr_SetString(PyExc_ZeroDivisionError, "float division");
    __PYX_ERR(0, 1431, __pyx_L1_error)
  }
  __pyx_v_pre_v_t = ((__pyx_v_treat_array_ptr[0]) / __pyx_v_denominator);

  /* "MACS2/IO/CallPeakUnit.pyx":1432
 *         pre_p_c = 0
 *         pre_v_t = treat_array_ptr[ 0 ]/denominator
 *         pre_v_c = ctrl_array_ptr [ 0 ]/denominator             # <<<<<<<<<<<<<<
 *         treat_array_ptr += 1
 *         ctrl_array_ptr += 1
 */
  __Pyx_TraceLine(1432,0,__PYX_ERR(0, 1432, __pyx_L1_error))
  if (unlikely(__pyx_v_denominator == 0)) {
    PyErr_SetString(PyExc_ZeroDivisionError, "float division");
    __PYX_ERR(0, 1432, __pyx_L1_error)
  }
  __pyx_v_pre_v_c = ((__pyx_v_ctrl_array_ptr[0]) / __pyx_v_denominator);

  /* "MACS2/IO/CallPeakUnit.pyx":1433
 *         pre_v_t = treat_array_ptr[ 0 ]/denominator
 *         pre_v_c = ctrl_array_ptr [ 0 ]/denominator
 *         treat_array_ptr += 1             # <<<<<<<<<<<<<<
 *         ctrl_array_ptr += 1
 * 
 */
  __Pyx_TraceLine(1433,0,__PYX_ERR(0, 1433, __pyx_L1_error))
  __pyx_v_treat_array_ptr = (__pyx_v_treat_array_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1434
 *         pre_v_c = ctrl_array_ptr [ 0 ]/denominator
 *         treat_array_ptr += 1
 *         ctrl_array_ptr += 1             # <<<<<<<<<<<<<<
 * 
 *         for i in range( 1, l ):
 */
  __Pyx_TraceLine(1434,0,__PYX_ERR(0, 1434, __pyx_L1_error))
  __pyx_v_ctrl_array_ptr = (__pyx_v_ctrl_array_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1436
 *         ctrl_array_ptr += 1
 * 
 *         for i in range( 1, l ):             # <<<<<<<<<<<<<<
 *             v_t = treat_array_ptr[ 0 ]/denominator
 *             v_c = ctrl_array_ptr [ 0 ]/denominator
 */
  __Pyx_TraceLine(1436,0,__PYX_ERR(0, 1436, __pyx_L1_error))
  __pyx_t_14 = __pyx_v_l;
  __pyx_t_15 = __pyx_t_14;
  for (__pyx_t_16 = 1; __pyx_t_16 < __pyx_t_15; __pyx_t_16+=1) {
    __pyx_v_i = __pyx_t_16;

    /* "MACS2/IO/CallPeakUnit.pyx":1437
 * 
 *         for i in range( 1, l ):
 *             v_t = treat_array_ptr[ 0 ]/denominator             # <<<<<<<<<<<<<<
 *             v_c = ctrl_array_ptr [ 0 ]/denominator
 *             p   = pos_array_ptr  [ 0 ]
 */
    __Pyx_TraceLine(1437,0,__PYX_ERR(0, 1437, __pyx_L1_error))
    if (unlikely(__pyx_v_denominator == 0)) {
      PyErr_SetString(PyExc_ZeroDivisionError, "float division");
      __PYX_ERR(0, 1437, __pyx_L1_error)
    }
    __pyx_v_v_t = ((__pyx_v_treat_array_ptr[0]) / __pyx_v_denominator);

    /* "MACS2/IO/CallPeakUnit.pyx":1438
 *         for i in range( 1, l ):
 *             v_t = treat_array_ptr[ 0 ]/denominator
 *             v_c = ctrl_array_ptr [ 0 ]/denominator             # <<<<<<<<<<<<<<
 *             p   = pos_array_ptr  [ 0 ]
 *             pos_array_ptr += 1
 */
    __Pyx_TraceLine(1438,0,__PYX_ERR(0, 1438, __pyx_L1_error))
    if (unlikely(__pyx_v_denominator == 0)) {
      PyErr_SetString(PyExc_ZeroDivisionError, "float division");
      __PYX_ERR(0, 1438, __pyx_L1_error)
    }
    __pyx_v_v_c = ((__pyx_v_ctrl_array_ptr[0]) / __pyx_v_denominator);

    /* "MACS2/IO/CallPeakUnit.pyx":1439
 *             v_t = treat_array_ptr[ 0 ]/denominator
 *             v_c = ctrl_array_ptr [ 0 ]/denominator
 *             p   = pos_array_ptr  [ 0 ]             # <<<<<<<<<<<<<<
 *             pos_array_ptr += 1
 *             treat_array_ptr += 1
 */
    __Pyx_TraceLine(1439,0,__PYX_ERR(0, 1439, __pyx_L1_error))
    __pyx_v_p = (__pyx_v_pos_array_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1440
 *             v_c = ctrl_array_ptr [ 0 ]/denominator
 *             p   = pos_array_ptr  [ 0 ]
 *             pos_array_ptr += 1             # <<<<<<<<<<<<<<
 *             treat_array_ptr += 1
 *             ctrl_array_ptr += 1
 */
    __Pyx_TraceLine(1440,0,__PYX_ERR(0, 1440, __pyx_L1_error))
    __pyx_v_pos_array_ptr = (__pyx_v_pos_array_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1441
 *             p   = pos_array_ptr  [ 0 ]
 *             pos_array_ptr += 1
 *             treat_array_ptr += 1             # <<<<<<<<<<<<<<
 *             ctrl_array_ptr += 1
 * 
 */
    __Pyx_TraceLine(1441,0,__PYX_ERR(0, 1441, __pyx_L1_error))
    __pyx_v_treat_array_ptr = (__pyx_v_treat_array_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1442
 *             pos_array_ptr += 1
 *             treat_array_ptr += 1
 *             ctrl_array_ptr += 1             # <<<<<<<<<<<<<<
 * 
 *             if abs(pre_v_t - v_t) > 1e-5: # precision is 5 digits
 */
    __Pyx_TraceLine(1442,0,__PYX_ERR(0, 1442, __pyx_L1_error))
    __pyx_v_ctrl_array_ptr = (__pyx_v_ctrl_array_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1444
 *             ctrl_array_ptr += 1
 * 
 *             if abs(pre_v_t - v_t) > 1e-5: # precision is 5 digits             # <<<<<<<<<<<<<<
 *                 fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )
 *                 pre_v_t = v_t
 */
    __Pyx_TraceLine(1444,0,__PYX_ERR(0, 1444, __pyx_L1_error))
    __pyx_t_11 = ((fabsf((__pyx_v_pre_v_t - __pyx_v_v_t)) > 1e-5) != 0);
    if (__pyx_t_11) {

      /* "MACS2/IO/CallPeakUnit.pyx":1445
 * 
 *             if abs(pre_v_t - v_t) > 1e-5: # precision is 5 digits
 *                 fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )             # <<<<<<<<<<<<<<
 *                 pre_v_t = v_t
 *                 pre_p_t = p
 */
      __Pyx_TraceLine(1445,0,__PYX_ERR(0, 1445, __pyx_L1_error))
      if (unlikely(__pyx_v_chrom == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
        __PYX_ERR(0, 1445, __pyx_L1_error)
      }
      __pyx_t_17 = __Pyx_PyBytes_AsWritableString(__pyx_v_chrom); if (unlikely((!__pyx_t_17) && PyErr_Occurred())) __PYX_ERR(0, 1445, __pyx_L1_error)
      (void)(fprintf(__pyx_v_ft, ((char const *)"%s\t%d\t%d\t%.5f\n"), __pyx_t_17, __pyx_v_pre_p_t, __pyx_v_p, __pyx_v_pre_v_t));

      /* "MACS2/IO/CallPeakUnit.pyx":1446
 *             if abs(pre_v_t - v_t) > 1e-5: # precision is 5 digits
 *                 fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )
 *                 pre_v_t = v_t             # <<<<<<<<<<<<<<
 *                 pre_p_t = p
 * 
 */
      __Pyx_TraceLine(1446,0,__PYX_ERR(0, 1446, __pyx_L1_error))
      __pyx_v_pre_v_t = __pyx_v_v_t;

      /* "MACS2/IO/CallPeakUnit.pyx":1447
 *                 fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )
 *                 pre_v_t = v_t
 *                 pre_p_t = p             # <<<<<<<<<<<<<<
 * 
 *             if abs(pre_v_c - v_c) > 1e-5: # precision is 5 digits
 */
      __Pyx_TraceLine(1447,0,__PYX_ERR(0, 1447, __pyx_L1_error))
      __pyx_v_pre_p_t = __pyx_v_p;

      /* "MACS2/IO/CallPeakUnit.pyx":1444
 *             ctrl_array_ptr += 1
 * 
 *             if abs(pre_v_t - v_t) > 1e-5: # precision is 5 digits             # <<<<<<<<<<<<<<
 *                 fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )
 *                 pre_v_t = v_t
 */
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1449
 *                 pre_p_t = p
 * 
 *             if abs(pre_v_c - v_c) > 1e-5: # precision is 5 digits             # <<<<<<<<<<<<<<
 *                 fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )
 *                 pre_v_c = v_c
 */
    __Pyx_TraceLine(1449,0,__PYX_ERR(0, 1449, __pyx_L1_error))
    __pyx_t_11 = ((fabsf((__pyx_v_pre_v_c - __pyx_v_v_c)) > 1e-5) != 0);
    if (__pyx_t_11) {

      /* "MACS2/IO/CallPeakUnit.pyx":1450
 * 
 *             if abs(pre_v_c - v_c) > 1e-5: # precision is 5 digits
 *                 fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )             # <<<<<<<<<<<<<<
 *                 pre_v_c = v_c
 *                 pre_p_c = p
 */
      __Pyx_TraceLine(1450,0,__PYX_ERR(0, 1450, __pyx_L1_error))
      if (unlikely(__pyx_v_chrom == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
        __PYX_ERR(0, 1450, __pyx_L1_error)
      }
      __pyx_t_17 = __Pyx_PyBytes_AsWritableString(__pyx_v_chrom); if (unlikely((!__pyx_t_17) && PyErr_Occurred())) __PYX_ERR(0, 1450, __pyx_L1_error)
      (void)(fprintf(__pyx_v_fc, ((char const *)"%s\t%d\t%d\t%.5f\n"), __pyx_t_17, __pyx_v_pre_p_c, __pyx_v_p, __pyx_v_pre_v_c));

      /* "MACS2/IO/CallPeakUnit.pyx":1451
 *             if abs(pre_v_c - v_c) > 1e-5: # precision is 5 digits
 *                 fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )
 *                 pre_v_c = v_c             # <<<<<<<<<<<<<<
 *                 pre_p_c = p
 * 
 */
      __Pyx_TraceLine(1451,0,__PYX_ERR(0, 1451, __pyx_L1_error))
      __pyx_v_pre_v_c = __pyx_v_v_c;

      /* "MACS2/IO/CallPeakUnit.pyx":1452
 *                 fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )
 *                 pre_v_c = v_c
 *                 pre_p_c = p             # <<<<<<<<<<<<<<
 * 
 *         p = pos_array_ptr[ 0 ]
 */
      __Pyx_TraceLine(1452,0,__PYX_ERR(0, 1452, __pyx_L1_error))
      __pyx_v_pre_p_c = __pyx_v_p;

      /* "MACS2/IO/CallPeakUnit.pyx":1449
 *                 pre_p_t = p
 * 
 *             if abs(pre_v_c - v_c) > 1e-5: # precision is 5 digits             # <<<<<<<<<<<<<<
 *                 fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )
 *                 pre_v_c = v_c
 */
    }
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1454
 *                 pre_p_c = p
 * 
 *         p = pos_array_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         # last one
 *         fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )
 */
  __Pyx_TraceLine(1454,0,__PYX_ERR(0, 1454, __pyx_L1_error))
  __pyx_v_p = (__pyx_v_pos_array_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1456
 *         p = pos_array_ptr[ 0 ]
 *         # last one
 *         fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )             # <<<<<<<<<<<<<<
 *         fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )
 * 
 */
  __Pyx_TraceLine(1456,0,__PYX_ERR(0, 1456, __pyx_L1_error))
  if (unlikely(__pyx_v_chrom == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
    __PYX_ERR(0, 1456, __pyx_L1_error)
  }
  __pyx_t_17 = __Pyx_PyBytes_AsWritableString(__pyx_v_chrom); if (unlikely((!__pyx_t_17) && PyErr_Occurred())) __PYX_ERR(0, 1456, __pyx_L1_error)
  (void)(fprintf(__pyx_v_ft, ((char const *)"%s\t%d\t%d\t%.5f\n"), __pyx_t_17, __pyx_v_pre_p_t, __pyx_v_p, __pyx_v_pre_v_t));

  /* "MACS2/IO/CallPeakUnit.pyx":1457
 *         # last one
 *         fprintf( ft, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_t, p, pre_v_t )
 *         fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )             # <<<<<<<<<<<<<<
 * 
 *         return True
 */
  __Pyx_TraceLine(1457,0,__PYX_ERR(0, 1457, __pyx_L1_error))
  if (unlikely(__pyx_v_chrom == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
    __PYX_ERR(0, 1457, __pyx_L1_error)
  }
  __pyx_t_17 = __Pyx_PyBytes_AsWritableString(__pyx_v_chrom); if (unlikely((!__pyx_t_17) && PyErr_Occurred())) __PYX_ERR(0, 1457, __pyx_L1_error)
  (void)(fprintf(__pyx_v_fc, ((char const *)"%s\t%d\t%d\t%.5f\n"), __pyx_t_17, __pyx_v_pre_p_c, __pyx_v_p, __pyx_v_pre_v_c));

  /* "MACS2/IO/CallPeakUnit.pyx":1459
 *         fprintf( fc, b"%s\t%d\t%d\t%.5f\n", chrom, pre_p_c, p, pre_v_c )
 * 
 *         return True             # <<<<<<<<<<<<<<
 * 
 *     cpdef call_broadpeaks (self, list scoring_function_symbols, list lvl1_cutoff_s, list lvl2_cutoff_s, int32_t min_length=200, int32_t lvl1_max_gap=50, int32_t lvl2_max_gap=400, bool cutoff_analysis = False):
 */
  __Pyx_TraceLine(1459,0,__PYX_ERR(0, 1459, __pyx_L1_error))
  __Pyx_XDECREF(((PyObject *)__pyx_r));
  __Pyx_INCREF(Py_True);
  __pyx_r = ((PyBoolObject *)Py_True);
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1385
 * 
 * 
 *     cdef bool __write_bedGraph_for_a_chromosome ( self, bytes chrom ):             # <<<<<<<<<<<<<<
 *         """Write treat/control values for a certain chromosome into a
 *         specified file handler.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  { PyObject *__pyx_type, *__pyx_value, *__pyx_tb;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&__pyx_type, &__pyx_value, &__pyx_tb);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer);
    __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer);
  __Pyx_ErrRestore(__pyx_type, __pyx_value, __pyx_tb);}
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__write_bedGraph_for_a_chromosome", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  goto __pyx_L2;
  __pyx_L0:;
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_ctrl_array.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_pos_array.rcbuffer->pybuffer);
  __Pyx_SafeReleaseBuffer(&__pyx_pybuffernd_treat_array.rcbuffer->pybuffer);
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_pos_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_treat_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_ctrl_array);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1461
 *         return True
 * 
 *     cpdef call_broadpeaks (self, list scoring_function_symbols, list lvl1_cutoff_s, list lvl2_cutoff_s, int32_t min_length=200, int32_t lvl1_max_gap=50, int32_t lvl2_max_gap=400, bool cutoff_analysis = False):             # <<<<<<<<<<<<<<
 *         """This function try to find enriched regions within which,
 *         scores are continuously higher than a given cutoff for level
 */

static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_11call_broadpeaks(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_lvl1_cutoff_s, PyObject *__pyx_v_lvl2_cutoff_s, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks *__pyx_optional_args) {
  __pyx_t_5numpy_int32_t __pyx_v_min_length = ((__pyx_t_5numpy_int32_t)0xC8);
  __pyx_t_5numpy_int32_t __pyx_v_lvl1_max_gap = ((__pyx_t_5numpy_int32_t)50);
  __pyx_t_5numpy_int32_t __pyx_v_lvl2_max_gap = ((__pyx_t_5numpy_int32_t)0x190);
  PyBoolObject *__pyx_v_cutoff_analysis = ((PyBoolObject *)Py_False);
  __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_int32_t __pyx_v_j;
  PyObject *__pyx_v_chrom = 0;
  PyObject *__pyx_v_lvl1peaks = 0;
  PyObject *__pyx_v_lvl1peakschrom = 0;
  PyObject *__pyx_v_lvl1 = 0;
  PyObject *__pyx_v_lvl2peaks = 0;
  PyObject *__pyx_v_lvl2peakschrom = 0;
  PyObject *__pyx_v_lvl2 = 0;
  PyObject *__pyx_v_broadpeaks = 0;
  PyObject *__pyx_v_chrs = 0;
  PyObject *__pyx_v_tmppeakset = 0;
  PyObject *__pyx_v_tmp_bytes = NULL;
  PyObject *__pyx_v_lvl1peakschrom_next = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  int __pyx_t_8;
  PyObject *__pyx_t_9 = NULL;
  int __pyx_t_10;
  int __pyx_t_11;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes __pyx_t_12;
  char const *__pyx_t_13;
  char const *__pyx_t_14;
  Py_ssize_t __pyx_t_15;
  Py_ssize_t __pyx_t_16;
  int __pyx_t_17;
  PyObject *__pyx_t_18 = NULL;
  PyObject *__pyx_t_19 = NULL;
  PyObject *__pyx_t_20 = NULL;
  Py_ssize_t __pyx_t_21;
  Py_ssize_t __pyx_t_22;
  __pyx_t_5numpy_int32_t __pyx_t_23;
  int __pyx_t_24;
  __Pyx_RefNannySetupContext("call_broadpeaks", 0);
  __Pyx_TraceCall("call_broadpeaks", __pyx_f[0], 1461, 0, __PYX_ERR(0, 1461, __pyx_L1_error));
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_min_length = __pyx_optional_args->min_length;
      if (__pyx_optional_args->__pyx_n > 1) {
        __pyx_v_lvl1_max_gap = __pyx_optional_args->lvl1_max_gap;
        if (__pyx_optional_args->__pyx_n > 2) {
          __pyx_v_lvl2_max_gap = __pyx_optional_args->lvl2_max_gap;
          if (__pyx_optional_args->__pyx_n > 3) {
            __pyx_v_cutoff_analysis = __pyx_optional_args->cutoff_analysis;
          }
        }
      }
    }
  }
  /* Check if called by wrapper */
  if (unlikely(__pyx_skip_dispatch)) ;
  /* Check if overridden in Python */
  else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || (Py_TYPE(((PyObject *)__pyx_v_self))->tp_flags & (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
    #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
    if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
      PY_UINT64_T __pyx_type_dict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      #endif
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_call_broadpeaks); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1461, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (!PyCFunction_Check(__pyx_t_1) || (PyCFunction_GET_FUNCTION(__pyx_t_1) != (PyCFunction)(void*)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_11call_broadpeaks)) {
        __Pyx_XDECREF(__pyx_r);
        __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_min_length); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1461, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_4 = __Pyx_PyInt_From_npy_int32(__pyx_v_lvl1_max_gap); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1461, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_lvl2_max_gap); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1461, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_5);
        __Pyx_INCREF(__pyx_t_1);
        __pyx_t_6 = __pyx_t_1; __pyx_t_7 = NULL;
        __pyx_t_8 = 0;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_6))) {
          __pyx_t_7 = PyMethod_GET_SELF(__pyx_t_6);
          if (likely(__pyx_t_7)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
            __Pyx_INCREF(__pyx_t_7);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_6, function);
            __pyx_t_8 = 1;
          }
        }
        #if CYTHON_FAST_PYCALL
        if (PyFunction_Check(__pyx_t_6)) {
          PyObject *__pyx_temp[8] = {__pyx_t_7, __pyx_v_scoring_function_symbols, __pyx_v_lvl1_cutoff_s, __pyx_v_lvl2_cutoff_s, __pyx_t_3, __pyx_t_4, __pyx_t_5, ((PyObject *)__pyx_v_cutoff_analysis)};
          __pyx_t_2 = __Pyx_PyFunction_FastCall(__pyx_t_6, __pyx_temp+1-__pyx_t_8, 7+__pyx_t_8); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1461, __pyx_L1_error)
          __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        } else
        #endif
        #if CYTHON_FAST_PYCCALL
        if (__Pyx_PyFastCFunction_Check(__pyx_t_6)) {
          PyObject *__pyx_temp[8] = {__pyx_t_7, __pyx_v_scoring_function_symbols, __pyx_v_lvl1_cutoff_s, __pyx_v_lvl2_cutoff_s, __pyx_t_3, __pyx_t_4, __pyx_t_5, ((PyObject *)__pyx_v_cutoff_analysis)};
          __pyx_t_2 = __Pyx_PyCFunction_FastCall(__pyx_t_6, __pyx_temp+1-__pyx_t_8, 7+__pyx_t_8); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1461, __pyx_L1_error)
          __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        } else
        #endif
        {
          __pyx_t_9 = PyTuple_New(7+__pyx_t_8); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1461, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_9);
          if (__pyx_t_7) {
            __Pyx_GIVEREF(__pyx_t_7); PyTuple_SET_ITEM(__pyx_t_9, 0, __pyx_t_7); __pyx_t_7 = NULL;
          }
          __Pyx_INCREF(__pyx_v_scoring_function_symbols);
          __Pyx_GIVEREF(__pyx_v_scoring_function_symbols);
          PyTuple_SET_ITEM(__pyx_t_9, 0+__pyx_t_8, __pyx_v_scoring_function_symbols);
          __Pyx_INCREF(__pyx_v_lvl1_cutoff_s);
          __Pyx_GIVEREF(__pyx_v_lvl1_cutoff_s);
          PyTuple_SET_ITEM(__pyx_t_9, 1+__pyx_t_8, __pyx_v_lvl1_cutoff_s);
          __Pyx_INCREF(__pyx_v_lvl2_cutoff_s);
          __Pyx_GIVEREF(__pyx_v_lvl2_cutoff_s);
          PyTuple_SET_ITEM(__pyx_t_9, 2+__pyx_t_8, __pyx_v_lvl2_cutoff_s);
          __Pyx_GIVEREF(__pyx_t_3);
          PyTuple_SET_ITEM(__pyx_t_9, 3+__pyx_t_8, __pyx_t_3);
          __Pyx_GIVEREF(__pyx_t_4);
          PyTuple_SET_ITEM(__pyx_t_9, 4+__pyx_t_8, __pyx_t_4);
          __Pyx_GIVEREF(__pyx_t_5);
          PyTuple_SET_ITEM(__pyx_t_9, 5+__pyx_t_8, __pyx_t_5);
          __Pyx_INCREF(((PyObject *)__pyx_v_cutoff_analysis));
          __Pyx_GIVEREF(((PyObject *)__pyx_v_cutoff_analysis));
          PyTuple_SET_ITEM(__pyx_t_9, 6+__pyx_t_8, ((PyObject *)__pyx_v_cutoff_analysis));
          __pyx_t_3 = 0;
          __pyx_t_4 = 0;
          __pyx_t_5 = 0;
          __pyx_t_2 = __Pyx_PyObject_Call(__pyx_t_6, __pyx_t_9, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1461, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
        }
        __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
        __pyx_r = __pyx_t_2;
        __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        goto __pyx_L0;
      }
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
      __pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      __pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
      if (unlikely(__pyx_type_dict_guard != __pyx_tp_dict_version)) {
        __pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
      }
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    }
    #endif
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1487
 *             list tmppeakset
 * 
 *         lvl1peaks = PeakIO()             # <<<<<<<<<<<<<<
 *         lvl2peaks = PeakIO()
 * 
 */
  __Pyx_TraceLine(1487,0,__PYX_ERR(0, 1487, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_PeakIO); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1487, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_1 = (__pyx_t_6) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_6) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1487, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_v_lvl1peaks = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1488
 * 
 *         lvl1peaks = PeakIO()
 *         lvl2peaks = PeakIO()             # <<<<<<<<<<<<<<
 * 
 *         # prepare p-q table
 */
  __Pyx_TraceLine(1488,0,__PYX_ERR(0, 1488, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_PeakIO); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1488, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_1 = (__pyx_t_6) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_6) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1488, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_v_lvl2peaks = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1491
 * 
 *         # prepare p-q table
 *         if not self.pqtable:             # <<<<<<<<<<<<<<
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:
 */
  __Pyx_TraceLine(1491,0,__PYX_ERR(0, 1491, __pyx_L1_error))
  __pyx_t_10 = __Pyx_PyObject_IsTrue(__pyx_v_self->pqtable); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 1491, __pyx_L1_error)
  __pyx_t_11 = ((!__pyx_t_10) != 0);
  if (__pyx_t_11) {

    /* "MACS2/IO/CallPeakUnit.pyx":1492
 *         # prepare p-q table
 *         if not self.pqtable:
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")             # <<<<<<<<<<<<<<
 *             if cutoff_analysis:
 *                 logging.info("#3 Cutoff value vs broad region calls will be analyzed!")
 */
    __Pyx_TraceLine(1492,0,__PYX_ERR(0, 1492, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1492, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1492, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
      }
    }
    __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_6, __pyx_t_2, __pyx_kp_u_3_Pre_compute_pvalue_qvalue_tab) : __Pyx_PyObject_CallOneArg(__pyx_t_6, __pyx_kp_u_3_Pre_compute_pvalue_qvalue_tab);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1492, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1493
 *         if not self.pqtable:
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:             # <<<<<<<<<<<<<<
 *                 logging.info("#3 Cutoff value vs broad region calls will be analyzed!")
 *                 self.__pre_computes( max_gap = lvl2_max_gap, min_length = min_length )
 */
    __Pyx_TraceLine(1493,0,__PYX_ERR(0, 1493, __pyx_L1_error))
    __pyx_t_11 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_cutoff_analysis)); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1493, __pyx_L1_error)
    if (__pyx_t_11) {

      /* "MACS2/IO/CallPeakUnit.pyx":1494
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:
 *                 logging.info("#3 Cutoff value vs broad region calls will be analyzed!")             # <<<<<<<<<<<<<<
 *                 self.__pre_computes( max_gap = lvl2_max_gap, min_length = min_length )
 *             else:
 */
      __Pyx_TraceLine(1494,0,__PYX_ERR(0, 1494, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_logging); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1494, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_info); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1494, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
      __pyx_t_6 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
        __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_2);
        if (likely(__pyx_t_6)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
          __Pyx_INCREF(__pyx_t_6);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_2, function);
        }
      }
      __pyx_t_1 = (__pyx_t_6) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_6, __pyx_kp_u_3_Cutoff_value_vs_broad_region) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_kp_u_3_Cutoff_value_vs_broad_region);
      __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1494, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1495
 *             if cutoff_analysis:
 *                 logging.info("#3 Cutoff value vs broad region calls will be analyzed!")
 *                 self.__pre_computes( max_gap = lvl2_max_gap, min_length = min_length )             # <<<<<<<<<<<<<<
 *             else:
 *                 self.__cal_pvalue_qvalue_table()
 */
      __Pyx_TraceLine(1495,0,__PYX_ERR(0, 1495, __pyx_L1_error))
      __pyx_t_12.__pyx_n = 2;
      __pyx_t_12.max_gap = __pyx_v_lvl2_max_gap;
      __pyx_t_12.min_length = __pyx_v_min_length;
      ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___pre_computes(__pyx_v_self, &__pyx_t_12); 

      /* "MACS2/IO/CallPeakUnit.pyx":1493
 *         if not self.pqtable:
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:             # <<<<<<<<<<<<<<
 *                 logging.info("#3 Cutoff value vs broad region calls will be analyzed!")
 *                 self.__pre_computes( max_gap = lvl2_max_gap, min_length = min_length )
 */
      goto __pyx_L4;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1497
 *                 self.__pre_computes( max_gap = lvl2_max_gap, min_length = min_length )
 *             else:
 *                 self.__cal_pvalue_qvalue_table()             # <<<<<<<<<<<<<<
 * 
 *         # prepare bedGraph file
 */
    __Pyx_TraceLine(1497,0,__PYX_ERR(0, 1497, __pyx_L1_error))
    /*else*/ {
      ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_pvalue_qvalue_table(__pyx_v_self);
    }
    __pyx_L4:;

    /* "MACS2/IO/CallPeakUnit.pyx":1491
 * 
 *         # prepare p-q table
 *         if not self.pqtable:             # <<<<<<<<<<<<<<
 *             logging.info("#3 Pre-compute pvalue-qvalue table...")
 *             if cutoff_analysis:
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1500
 * 
 *         # prepare bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 * 
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )
 */
  __Pyx_TraceLine(1500,0,__PYX_ERR(0, 1500, __pyx_L1_error))
  __pyx_t_11 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->save_bedGraph)); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1500, __pyx_L1_error)
  if (__pyx_t_11) {

    /* "MACS2/IO/CallPeakUnit.pyx":1502
 *         if self.save_bedGraph:
 * 
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )             # <<<<<<<<<<<<<<
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")
 */
    __Pyx_TraceLine(1502,0,__PYX_ERR(0, 1502, __pyx_L1_error))
    if (unlikely(__pyx_v_self->bedGraph_treat_filename == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 1502, __pyx_L1_error)
    }
    __pyx_t_13 = __Pyx_PyBytes_AsString(__pyx_v_self->bedGraph_treat_filename); if (unlikely((!__pyx_t_13) && PyErr_Occurred())) __PYX_ERR(0, 1502, __pyx_L1_error)
    __pyx_v_self->bedGraph_treat_f = fopen(__pyx_t_13, ((char const *)"w"));

    /* "MACS2/IO/CallPeakUnit.pyx":1503
 * 
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )             # <<<<<<<<<<<<<<
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")
 *             logging.info ("#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_treat_pileup.bdg")
 */
    __Pyx_TraceLine(1503,0,__PYX_ERR(0, 1503, __pyx_L1_error))
    if (unlikely(__pyx_v_self->bedGraph_control_filename == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "expected bytes, NoneType found");
      __PYX_ERR(0, 1503, __pyx_L1_error)
    }
    __pyx_t_13 = __Pyx_PyBytes_AsString(__pyx_v_self->bedGraph_control_filename); if (unlikely((!__pyx_t_13) && PyErr_Occurred())) __PYX_ERR(0, 1503, __pyx_L1_error)
    __pyx_v_self->bedGraph_ctrl_f = fopen(__pyx_t_13, ((char const *)"w"));

    /* "MACS2/IO/CallPeakUnit.pyx":1504
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")             # <<<<<<<<<<<<<<
 *             logging.info ("#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_treat_pileup.bdg")
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 */
    __Pyx_TraceLine(1504,0,__PYX_ERR(0, 1504, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1504, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1504, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
      }
    }
    __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_6, __pyx_t_2, __pyx_kp_u_3_In_the_peak_calling_step_the) : __Pyx_PyObject_CallOneArg(__pyx_t_6, __pyx_kp_u_3_In_the_peak_calling_step_the);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1504, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1505
 *             self.bedGraph_ctrl_f = fopen( self.bedGraph_control_filename, "w" )
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")
 *             logging.info ("#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_treat_pileup.bdg")             # <<<<<<<<<<<<<<
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 * 
 */
    __Pyx_TraceLine(1505,0,__PYX_ERR(0, 1505, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_logging); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1505, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_info); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1505, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    if (unlikely(__pyx_v_self->bedGraph_filename_prefix == Py_None)) {
      PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "decode");
      __PYX_ERR(0, 1505, __pyx_L1_error)
    }
    __pyx_t_6 = __Pyx_decode_bytes(__pyx_v_self->bedGraph_filename_prefix, 0, PY_SSIZE_T_MAX, NULL, NULL, NULL); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1505, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_9 = PyUnicode_Format(__pyx_kp_u_3_Write_bedGraph_files_for_trea, __pyx_t_6); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1505, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __pyx_t_6 = __Pyx_PyUnicode_Concat(__pyx_t_9, __pyx_kp_u_treat_pileup_bdg); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1505, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __pyx_t_9 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_9)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_9);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
      }
    }
    __pyx_t_1 = (__pyx_t_9) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_9, __pyx_t_6) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_6);
    __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1505, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1506
 *             logging.info ("#3 In the peak calling step, the following will be performed simultaneously:")
 *             logging.info ("#3   Write bedGraph files for treatment pileup (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_treat_pileup.bdg")
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")             # <<<<<<<<<<<<<<
 * 
 *             if self.trackline:
 */
    __Pyx_TraceLine(1506,0,__PYX_ERR(0, 1506, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_logging); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1506, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_info); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1506, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(__pyx_v_self->bedGraph_filename_prefix == Py_None)) {
      PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "decode");
      __PYX_ERR(0, 1506, __pyx_L1_error)
    }
    __pyx_t_2 = __Pyx_decode_bytes(__pyx_v_self->bedGraph_filename_prefix, 0, PY_SSIZE_T_MAX, NULL, NULL, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1506, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_9 = PyUnicode_Format(__pyx_kp_u_3_Write_bedGraph_files_for_cont, __pyx_t_2); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1506, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __pyx_t_2 = __Pyx_PyUnicode_Concat(__pyx_t_9, __pyx_kp_u_control_lambda_bdg); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1506, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __pyx_t_9 = NULL;
    if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_9)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_9);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
      }
    }
    __pyx_t_1 = (__pyx_t_9) ? __Pyx_PyObject_Call2Args(__pyx_t_6, __pyx_t_9, __pyx_t_2) : __Pyx_PyObject_CallOneArg(__pyx_t_6, __pyx_t_2);
    __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1506, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1508
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 * 
 *             if self.trackline:             # <<<<<<<<<<<<<<
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 */
    __Pyx_TraceLine(1508,0,__PYX_ERR(0, 1508, __pyx_L1_error))
    __pyx_t_11 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->trackline)); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1508, __pyx_L1_error)
    if (__pyx_t_11) {

      /* "MACS2/IO/CallPeakUnit.pyx":1510
 *             if self.trackline:
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()             # <<<<<<<<<<<<<<
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 */
      __Pyx_TraceLine(1510,0,__PYX_ERR(0, 1510, __pyx_L1_error))
      __pyx_t_1 = PyUnicode_Format(__pyx_kp_u_track_type_bedGraph_name_treatme, __pyx_v_self->bedGraph_filename_prefix); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1510, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_6 = PyUnicode_AsEncodedString(((PyObject*)__pyx_t_1), NULL, NULL); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1510, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_v_tmp_bytes = __pyx_t_6;
      __pyx_t_6 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1511
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )             # <<<<<<<<<<<<<<
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_ctrl_f, tmp_bytes )
 */
      __Pyx_TraceLine(1511,0,__PYX_ERR(0, 1511, __pyx_L1_error))
      __pyx_t_14 = __Pyx_PyObject_AsString(__pyx_v_tmp_bytes); if (unlikely((!__pyx_t_14) && PyErr_Occurred())) __PYX_ERR(0, 1511, __pyx_L1_error)
      (void)(fprintf(__pyx_v_self->bedGraph_treat_f, __pyx_t_14));

      /* "MACS2/IO/CallPeakUnit.pyx":1512
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()             # <<<<<<<<<<<<<<
 *                 fprintf( self.bedGraph_ctrl_f, tmp_bytes )
 * 
 */
      __Pyx_TraceLine(1512,0,__PYX_ERR(0, 1512, __pyx_L1_error))
      __pyx_t_6 = PyUnicode_Format(__pyx_kp_u_track_type_bedGraph_name_control, __pyx_v_self->bedGraph_filename_prefix); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1512, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __pyx_t_1 = PyUnicode_AsEncodedString(((PyObject*)__pyx_t_6), NULL, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1512, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
      __Pyx_DECREF_SET(__pyx_v_tmp_bytes, __pyx_t_1);
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1513
 *                 fprintf( self.bedGraph_treat_f, tmp_bytes )
 *                 tmp_bytes = ("track type=bedGraph name=\"control lambda\" description=\"control lambda after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 *                 fprintf( self.bedGraph_ctrl_f, tmp_bytes )             # <<<<<<<<<<<<<<
 * 
 * 
 */
      __Pyx_TraceLine(1513,0,__PYX_ERR(0, 1513, __pyx_L1_error))
      __pyx_t_14 = __Pyx_PyObject_AsString(__pyx_v_tmp_bytes); if (unlikely((!__pyx_t_14) && PyErr_Occurred())) __PYX_ERR(0, 1513, __pyx_L1_error)
      (void)(fprintf(__pyx_v_self->bedGraph_ctrl_f, __pyx_t_14));

      /* "MACS2/IO/CallPeakUnit.pyx":1508
 *             logging.info ("#3   Write bedGraph files for control lambda (after scaling if necessary)... %s" % self.bedGraph_filename_prefix.decode() + "_control_lambda.bdg")
 * 
 *             if self.trackline:             # <<<<<<<<<<<<<<
 *                 # this line is REQUIRED by the wiggle format for UCSC browser
 *                 tmp_bytes = ("track type=bedGraph name=\"treatment pileup\" description=\"treatment pileup after possible scaling for \'%s\'\"\n" % self.bedGraph_filename_prefix).encode()
 */
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1500
 * 
 *         # prepare bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 * 
 *             self.bedGraph_treat_f = fopen( self.bedGraph_treat_filename, "w" )
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1516
 * 
 * 
 *         logging.info("#3 Call peaks for each chromosome...")             # <<<<<<<<<<<<<<
 *         for chrom in self.chromosomes:
 *             self.__chrom_call_broadpeak_using_certain_criteria ( lvl1peaks, lvl2peaks, chrom, scoring_function_symbols, lvl1_cutoff_s, lvl2_cutoff_s, min_length, lvl1_max_gap, lvl2_max_gap, self.save_bedGraph )
 */
  __Pyx_TraceLine(1516,0,__PYX_ERR(0, 1516, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_logging); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1516, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_info); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1516, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_1 = (__pyx_t_6) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_6, __pyx_kp_u_3_Call_peaks_for_each_chromosom) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_kp_u_3_Call_peaks_for_each_chromosom);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1516, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1517
 * 
 *         logging.info("#3 Call peaks for each chromosome...")
 *         for chrom in self.chromosomes:             # <<<<<<<<<<<<<<
 *             self.__chrom_call_broadpeak_using_certain_criteria ( lvl1peaks, lvl2peaks, chrom, scoring_function_symbols, lvl1_cutoff_s, lvl2_cutoff_s, min_length, lvl1_max_gap, lvl2_max_gap, self.save_bedGraph )
 * 
 */
  __Pyx_TraceLine(1517,0,__PYX_ERR(0, 1517, __pyx_L1_error))
  if (unlikely(__pyx_v_self->chromosomes == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
    __PYX_ERR(0, 1517, __pyx_L1_error)
  }
  __pyx_t_1 = __pyx_v_self->chromosomes; __Pyx_INCREF(__pyx_t_1); __pyx_t_15 = 0;
  for (;;) {
    if (__pyx_t_15 >= PyList_GET_SIZE(__pyx_t_1)) break;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_2 = PyList_GET_ITEM(__pyx_t_1, __pyx_t_15); __Pyx_INCREF(__pyx_t_2); __pyx_t_15++; if (unlikely(0 < 0)) __PYX_ERR(0, 1517, __pyx_L1_error)
    #else
    __pyx_t_2 = PySequence_ITEM(__pyx_t_1, __pyx_t_15); __pyx_t_15++; if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1517, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    #endif
    if (!(likely(PyBytes_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_2)->tp_name), 0))) __PYX_ERR(0, 1517, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_chrom, ((PyObject*)__pyx_t_2));
    __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1518
 *         logging.info("#3 Call peaks for each chromosome...")
 *         for chrom in self.chromosomes:
 *             self.__chrom_call_broadpeak_using_certain_criteria ( lvl1peaks, lvl2peaks, chrom, scoring_function_symbols, lvl1_cutoff_s, lvl2_cutoff_s, min_length, lvl1_max_gap, lvl2_max_gap, self.save_bedGraph )             # <<<<<<<<<<<<<<
 * 
 *         # close bedGraph file
 */
    __Pyx_TraceLine(1518,0,__PYX_ERR(0, 1518, __pyx_L1_error))
    __pyx_t_2 = ((PyObject *)__pyx_v_self->save_bedGraph);
    __Pyx_INCREF(__pyx_t_2);
    ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___chrom_call_broadpeak_using_certain_criteria(__pyx_v_self, __pyx_v_lvl1peaks, __pyx_v_lvl2peaks, __pyx_v_chrom, __pyx_v_scoring_function_symbols, __pyx_v_lvl1_cutoff_s, __pyx_v_lvl2_cutoff_s, __pyx_v_min_length, __pyx_v_lvl1_max_gap, __pyx_v_lvl2_max_gap, ((PyBoolObject *)__pyx_t_2));
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1517
 * 
 *         logging.info("#3 Call peaks for each chromosome...")
 *         for chrom in self.chromosomes:             # <<<<<<<<<<<<<<
 *             self.__chrom_call_broadpeak_using_certain_criteria ( lvl1peaks, lvl2peaks, chrom, scoring_function_symbols, lvl1_cutoff_s, lvl2_cutoff_s, min_length, lvl1_max_gap, lvl2_max_gap, self.save_bedGraph )
 * 
 */
    __Pyx_TraceLine(1517,0,__PYX_ERR(0, 1517, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1521
 * 
 *         # close bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 *             fclose( self.bedGraph_treat_f )
 *             fclose( self.bedGraph_ctrl_f )
 */
  __Pyx_TraceLine(1521,0,__PYX_ERR(0, 1521, __pyx_L1_error))
  __pyx_t_11 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->save_bedGraph)); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1521, __pyx_L1_error)
  if (__pyx_t_11) {

    /* "MACS2/IO/CallPeakUnit.pyx":1522
 *         # close bedGraph file
 *         if self.save_bedGraph:
 *             fclose( self.bedGraph_treat_f )             # <<<<<<<<<<<<<<
 *             fclose( self.bedGraph_ctrl_f )
 *             #self.bedGraph_ctrl.close()
 */
    __Pyx_TraceLine(1522,0,__PYX_ERR(0, 1522, __pyx_L1_error))
    (void)(fclose(__pyx_v_self->bedGraph_treat_f));

    /* "MACS2/IO/CallPeakUnit.pyx":1523
 *         if self.save_bedGraph:
 *             fclose( self.bedGraph_treat_f )
 *             fclose( self.bedGraph_ctrl_f )             # <<<<<<<<<<<<<<
 *             #self.bedGraph_ctrl.close()
 *             self.save_bedGraph = False
 */
    __Pyx_TraceLine(1523,0,__PYX_ERR(0, 1523, __pyx_L1_error))
    (void)(fclose(__pyx_v_self->bedGraph_ctrl_f));

    /* "MACS2/IO/CallPeakUnit.pyx":1525
 *             fclose( self.bedGraph_ctrl_f )
 *             #self.bedGraph_ctrl.close()
 *             self.save_bedGraph = False             # <<<<<<<<<<<<<<
 * 
 *         # now combine lvl1 and lvl2 peaks
 */
    __Pyx_TraceLine(1525,0,__PYX_ERR(0, 1525, __pyx_L1_error))
    __Pyx_INCREF(Py_False);
    __Pyx_GIVEREF(Py_False);
    __Pyx_GOTREF(__pyx_v_self->save_bedGraph);
    __Pyx_DECREF(((PyObject *)__pyx_v_self->save_bedGraph));
    __pyx_v_self->save_bedGraph = ((PyBoolObject *)Py_False);

    /* "MACS2/IO/CallPeakUnit.pyx":1521
 * 
 *         # close bedGraph file
 *         if self.save_bedGraph:             # <<<<<<<<<<<<<<
 *             fclose( self.bedGraph_treat_f )
 *             fclose( self.bedGraph_ctrl_f )
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1528
 * 
 *         # now combine lvl1 and lvl2 peaks
 *         chrs = lvl1peaks.get_chr_names()             # <<<<<<<<<<<<<<
 *         broadpeaks = BroadPeakIO()
 *         # use lvl2_peaks as linking regions between lvl1_peaks
 */
  __Pyx_TraceLine(1528,0,__PYX_ERR(0, 1528, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_lvl1peaks, __pyx_n_s_get_chr_names); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1528, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_1 = (__pyx_t_6) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_6) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1528, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (!(likely(PySet_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "set", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 1528, __pyx_L1_error)
  __pyx_v_chrs = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1529
 *         # now combine lvl1 and lvl2 peaks
 *         chrs = lvl1peaks.get_chr_names()
 *         broadpeaks = BroadPeakIO()             # <<<<<<<<<<<<<<
 *         # use lvl2_peaks as linking regions between lvl1_peaks
 *         for chrom in chrs:
 */
  __Pyx_TraceLine(1529,0,__PYX_ERR(0, 1529, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_BroadPeakIO); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1529, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_t_6 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
    __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_2);
    if (likely(__pyx_t_6)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
      __Pyx_INCREF(__pyx_t_6);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_2, function);
    }
  }
  __pyx_t_1 = (__pyx_t_6) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_6) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1529, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_v_broadpeaks = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1531
 *         broadpeaks = BroadPeakIO()
 *         # use lvl2_peaks as linking regions between lvl1_peaks
 *         for chrom in chrs:             # <<<<<<<<<<<<<<
 *             lvl1peakschrom = lvl1peaks.get_data_from_chrom(chrom)
 *             lvl2peakschrom = lvl2peaks.get_data_from_chrom(chrom)
 */
  __Pyx_TraceLine(1531,0,__PYX_ERR(0, 1531, __pyx_L1_error))
  __pyx_t_15 = 0;
  __pyx_t_2 = __Pyx_set_iterator(__pyx_v_chrs, 1, (&__pyx_t_16), (&__pyx_t_8)); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1531, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_1);
  __pyx_t_1 = __pyx_t_2;
  __pyx_t_2 = 0;
  while (1) {
    __pyx_t_17 = __Pyx_set_iter_next(__pyx_t_1, __pyx_t_16, &__pyx_t_15, &__pyx_t_2, __pyx_t_8);
    if (unlikely(__pyx_t_17 == 0)) break;
    if (unlikely(__pyx_t_17 == -1)) __PYX_ERR(0, 1531, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    if (!(likely(PyBytes_CheckExact(__pyx_t_2))||((__pyx_t_2) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_2)->tp_name), 0))) __PYX_ERR(0, 1531, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_chrom, ((PyObject*)__pyx_t_2));
    __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1532
 *         # use lvl2_peaks as linking regions between lvl1_peaks
 *         for chrom in chrs:
 *             lvl1peakschrom = lvl1peaks.get_data_from_chrom(chrom)             # <<<<<<<<<<<<<<
 *             lvl2peakschrom = lvl2peaks.get_data_from_chrom(chrom)
 *             lvl1peakschrom_next = iter(lvl1peakschrom).__next__
 */
    __Pyx_TraceLine(1532,0,__PYX_ERR(0, 1532, __pyx_L1_error))
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_v_lvl1peaks, __pyx_n_s_get_data_from_chrom); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1532, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_9 = NULL;
    if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_9)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_9);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
      }
    }
    __pyx_t_2 = (__pyx_t_9) ? __Pyx_PyObject_Call2Args(__pyx_t_6, __pyx_t_9, __pyx_v_chrom) : __Pyx_PyObject_CallOneArg(__pyx_t_6, __pyx_v_chrom);
    __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
    if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1532, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_XDECREF_SET(__pyx_v_lvl1peakschrom, __pyx_t_2);
    __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1533
 *         for chrom in chrs:
 *             lvl1peakschrom = lvl1peaks.get_data_from_chrom(chrom)
 *             lvl2peakschrom = lvl2peaks.get_data_from_chrom(chrom)             # <<<<<<<<<<<<<<
 *             lvl1peakschrom_next = iter(lvl1peakschrom).__next__
 *             tmppeakset = []             # to temporarily store lvl1 region inside a lvl2 region
 */
    __Pyx_TraceLine(1533,0,__PYX_ERR(0, 1533, __pyx_L1_error))
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_v_lvl2peaks, __pyx_n_s_get_data_from_chrom); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1533, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_9 = NULL;
    if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_6))) {
      __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_6);
      if (likely(__pyx_t_9)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_6);
        __Pyx_INCREF(__pyx_t_9);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_6, function);
      }
    }
    __pyx_t_2 = (__pyx_t_9) ? __Pyx_PyObject_Call2Args(__pyx_t_6, __pyx_t_9, __pyx_v_chrom) : __Pyx_PyObject_CallOneArg(__pyx_t_6, __pyx_v_chrom);
    __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
    if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1533, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_XDECREF_SET(__pyx_v_lvl2peakschrom, __pyx_t_2);
    __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1534
 *             lvl1peakschrom = lvl1peaks.get_data_from_chrom(chrom)
 *             lvl2peakschrom = lvl2peaks.get_data_from_chrom(chrom)
 *             lvl1peakschrom_next = iter(lvl1peakschrom).__next__             # <<<<<<<<<<<<<<
 *             tmppeakset = []             # to temporarily store lvl1 region inside a lvl2 region
 *             # our assumption is lvl1 regions should be included in lvl2 regions
 */
    __Pyx_TraceLine(1534,0,__PYX_ERR(0, 1534, __pyx_L1_error))
    __pyx_t_2 = PyObject_GetIter(__pyx_v_lvl1peakschrom); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1534, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_next); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1534, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF_SET(__pyx_v_lvl1peakschrom_next, __pyx_t_6);
    __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1535
 *             lvl2peakschrom = lvl2peaks.get_data_from_chrom(chrom)
 *             lvl1peakschrom_next = iter(lvl1peakschrom).__next__
 *             tmppeakset = []             # to temporarily store lvl1 region inside a lvl2 region             # <<<<<<<<<<<<<<
 *             # our assumption is lvl1 regions should be included in lvl2 regions
 *             try:
 */
    __Pyx_TraceLine(1535,0,__PYX_ERR(0, 1535, __pyx_L1_error))
    __pyx_t_6 = PyList_New(0); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1535, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_XDECREF_SET(__pyx_v_tmppeakset, ((PyObject*)__pyx_t_6));
    __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1537
 *             tmppeakset = []             # to temporarily store lvl1 region inside a lvl2 region
 *             # our assumption is lvl1 regions should be included in lvl2 regions
 *             try:             # <<<<<<<<<<<<<<
 *                 lvl1 = lvl1peakschrom_next()
 *                 for i in range( len(lvl2peakschrom) ):
 */
    __Pyx_TraceLine(1537,0,__PYX_ERR(0, 1537, __pyx_L1_error))
    {
      __Pyx_PyThreadState_declare
      __Pyx_PyThreadState_assign
      __Pyx_ExceptionSave(&__pyx_t_18, &__pyx_t_19, &__pyx_t_20);
      __Pyx_XGOTREF(__pyx_t_18);
      __Pyx_XGOTREF(__pyx_t_19);
      __Pyx_XGOTREF(__pyx_t_20);
      /*try:*/ {

        /* "MACS2/IO/CallPeakUnit.pyx":1538
 *             # our assumption is lvl1 regions should be included in lvl2 regions
 *             try:
 *                 lvl1 = lvl1peakschrom_next()             # <<<<<<<<<<<<<<
 *                 for i in range( len(lvl2peakschrom) ):
 *                     # for each lvl2 peak, find all lvl1 peaks inside
 */
        __Pyx_TraceLine(1538,0,__PYX_ERR(0, 1538, __pyx_L12_error))
        __Pyx_INCREF(__pyx_v_lvl1peakschrom_next);
        __pyx_t_2 = __pyx_v_lvl1peakschrom_next; __pyx_t_9 = NULL;
        if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
          __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_2);
          if (likely(__pyx_t_9)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
            __Pyx_INCREF(__pyx_t_9);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_2, function);
          }
        }
        __pyx_t_6 = (__pyx_t_9) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_9) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
        __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
        if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1538, __pyx_L12_error)
        __Pyx_GOTREF(__pyx_t_6);
        __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_XDECREF_SET(__pyx_v_lvl1, __pyx_t_6);
        __pyx_t_6 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1539
 *             try:
 *                 lvl1 = lvl1peakschrom_next()
 *                 for i in range( len(lvl2peakschrom) ):             # <<<<<<<<<<<<<<
 *                     # for each lvl2 peak, find all lvl1 peaks inside
 *                     # I assume lvl1 peaks can be ALL covered by lvl2 peaks.
 */
        __Pyx_TraceLine(1539,0,__PYX_ERR(0, 1539, __pyx_L12_error))
        __pyx_t_21 = PyObject_Length(__pyx_v_lvl2peakschrom); if (unlikely(__pyx_t_21 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1539, __pyx_L12_error)
        __pyx_t_22 = __pyx_t_21;
        for (__pyx_t_23 = 0; __pyx_t_23 < __pyx_t_22; __pyx_t_23+=1) {
          __pyx_v_i = __pyx_t_23;

          /* "MACS2/IO/CallPeakUnit.pyx":1542
 *                     # for each lvl2 peak, find all lvl1 peaks inside
 *                     # I assume lvl1 peaks can be ALL covered by lvl2 peaks.
 *                     lvl2 = lvl2peakschrom[i]             # <<<<<<<<<<<<<<
 * 
 *                     while True:
 */
          __Pyx_TraceLine(1542,0,__PYX_ERR(0, 1542, __pyx_L12_error))
          __pyx_t_6 = __Pyx_GetItemInt(__pyx_v_lvl2peakschrom, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1542, __pyx_L12_error)
          __Pyx_GOTREF(__pyx_t_6);
          __Pyx_XDECREF_SET(__pyx_v_lvl2, __pyx_t_6);
          __pyx_t_6 = 0;

          /* "MACS2/IO/CallPeakUnit.pyx":1544
 *                     lvl2 = lvl2peakschrom[i]
 * 
 *                     while True:             # <<<<<<<<<<<<<<
 *                         if lvl2["start"] <= lvl1["start"]  and lvl1["end"] <= lvl2["end"]:
 *                             tmppeakset.append(lvl1)
 */
          __Pyx_TraceLine(1544,0,__PYX_ERR(0, 1544, __pyx_L12_error))
          while (1) {

            /* "MACS2/IO/CallPeakUnit.pyx":1545
 * 
 *                     while True:
 *                         if lvl2["start"] <= lvl1["start"]  and lvl1["end"] <= lvl2["end"]:             # <<<<<<<<<<<<<<
 *                             tmppeakset.append(lvl1)
 *                             lvl1 = lvl1peakschrom_next()
 */
            __Pyx_TraceLine(1545,0,__PYX_ERR(0, 1545, __pyx_L12_error))
            __pyx_t_6 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2, __pyx_n_u_start); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_GOTREF(__pyx_t_6);
            __pyx_t_2 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl1, __pyx_n_u_start); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_GOTREF(__pyx_t_2);
            __pyx_t_9 = PyObject_RichCompare(__pyx_t_6, __pyx_t_2, Py_LE); __Pyx_XGOTREF(__pyx_t_9); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
            __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
            __pyx_t_10 = __Pyx_PyObject_IsTrue(__pyx_t_9); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
            if (__pyx_t_10) {
            } else {
              __pyx_t_11 = __pyx_t_10;
              goto __pyx_L25_bool_binop_done;
            }
            __pyx_t_9 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl1, __pyx_n_u_end); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_GOTREF(__pyx_t_9);
            __pyx_t_2 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2, __pyx_n_u_end); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_GOTREF(__pyx_t_2);
            __pyx_t_6 = PyObject_RichCompare(__pyx_t_9, __pyx_t_2, Py_LE); __Pyx_XGOTREF(__pyx_t_6); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
            __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
            __pyx_t_10 = __Pyx_PyObject_IsTrue(__pyx_t_6); if (unlikely(__pyx_t_10 < 0)) __PYX_ERR(0, 1545, __pyx_L12_error)
            __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
            __pyx_t_11 = __pyx_t_10;
            __pyx_L25_bool_binop_done:;
            if (__pyx_t_11) {

              /* "MACS2/IO/CallPeakUnit.pyx":1546
 *                     while True:
 *                         if lvl2["start"] <= lvl1["start"]  and lvl1["end"] <= lvl2["end"]:
 *                             tmppeakset.append(lvl1)             # <<<<<<<<<<<<<<
 *                             lvl1 = lvl1peakschrom_next()
 *                         else:
 */
              __Pyx_TraceLine(1546,0,__PYX_ERR(0, 1546, __pyx_L12_error))
              __pyx_t_24 = __Pyx_PyList_Append(__pyx_v_tmppeakset, __pyx_v_lvl1); if (unlikely(__pyx_t_24 == ((int)-1))) __PYX_ERR(0, 1546, __pyx_L12_error)

              /* "MACS2/IO/CallPeakUnit.pyx":1547
 *                         if lvl2["start"] <= lvl1["start"]  and lvl1["end"] <= lvl2["end"]:
 *                             tmppeakset.append(lvl1)
 *                             lvl1 = lvl1peakschrom_next()             # <<<<<<<<<<<<<<
 *                         else:
 *                             # make a hierarchical broad peak
 */
              __Pyx_TraceLine(1547,0,__PYX_ERR(0, 1547, __pyx_L12_error))
              __Pyx_INCREF(__pyx_v_lvl1peakschrom_next);
              __pyx_t_2 = __pyx_v_lvl1peakschrom_next; __pyx_t_9 = NULL;
              if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
                __pyx_t_9 = PyMethod_GET_SELF(__pyx_t_2);
                if (likely(__pyx_t_9)) {
                  PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
                  __Pyx_INCREF(__pyx_t_9);
                  __Pyx_INCREF(function);
                  __Pyx_DECREF_SET(__pyx_t_2, function);
                }
              }
              __pyx_t_6 = (__pyx_t_9) ? __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_t_9) : __Pyx_PyObject_CallNoArg(__pyx_t_2);
              __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
              if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1547, __pyx_L12_error)
              __Pyx_GOTREF(__pyx_t_6);
              __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
              __Pyx_DECREF_SET(__pyx_v_lvl1, __pyx_t_6);
              __pyx_t_6 = 0;

              /* "MACS2/IO/CallPeakUnit.pyx":1545
 * 
 *                     while True:
 *                         if lvl2["start"] <= lvl1["start"]  and lvl1["end"] <= lvl2["end"]:             # <<<<<<<<<<<<<<
 *                             tmppeakset.append(lvl1)
 *                             lvl1 = lvl1peakschrom_next()
 */
              goto __pyx_L24;
            }

            /* "MACS2/IO/CallPeakUnit.pyx":1551
 *                             # make a hierarchical broad peak
 *                             #print lvl2["start"], lvl2["end"], lvl2["score"]
 *                             self.__add_broadpeak ( broadpeaks, chrom, lvl2, tmppeakset)             # <<<<<<<<<<<<<<
 *                             tmppeakset = []
 *                             break
 */
            __Pyx_TraceLine(1551,0,__PYX_ERR(0, 1551, __pyx_L12_error))
            /*else*/ {
              __pyx_t_6 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___add_broadpeak(__pyx_v_self, __pyx_v_broadpeaks, __pyx_v_chrom, __pyx_v_lvl2, __pyx_v_tmppeakset); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1551, __pyx_L12_error)
              __Pyx_GOTREF(__pyx_t_6);
              __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;

              /* "MACS2/IO/CallPeakUnit.pyx":1552
 *                             #print lvl2["start"], lvl2["end"], lvl2["score"]
 *                             self.__add_broadpeak ( broadpeaks, chrom, lvl2, tmppeakset)
 *                             tmppeakset = []             # <<<<<<<<<<<<<<
 *                             break
 *             except StopIteration:
 */
              __Pyx_TraceLine(1552,0,__PYX_ERR(0, 1552, __pyx_L12_error))
              __pyx_t_6 = PyList_New(0); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1552, __pyx_L12_error)
              __Pyx_GOTREF(__pyx_t_6);
              __Pyx_DECREF_SET(__pyx_v_tmppeakset, ((PyObject*)__pyx_t_6));
              __pyx_t_6 = 0;

              /* "MACS2/IO/CallPeakUnit.pyx":1553
 *                             self.__add_broadpeak ( broadpeaks, chrom, lvl2, tmppeakset)
 *                             tmppeakset = []
 *                             break             # <<<<<<<<<<<<<<
 *             except StopIteration:
 *                 # no more strong (aka lvl1) peaks left
 */
              __Pyx_TraceLine(1553,0,__PYX_ERR(0, 1553, __pyx_L12_error))
              goto __pyx_L23_break;
            }
            __pyx_L24:;
          }
          __pyx_L23_break:;
        }

        /* "MACS2/IO/CallPeakUnit.pyx":1537
 *             tmppeakset = []             # to temporarily store lvl1 region inside a lvl2 region
 *             # our assumption is lvl1 regions should be included in lvl2 regions
 *             try:             # <<<<<<<<<<<<<<
 *                 lvl1 = lvl1peakschrom_next()
 *                 for i in range( len(lvl2peakschrom) ):
 */
      }
      __Pyx_XDECREF(__pyx_t_18); __pyx_t_18 = 0;
      __Pyx_XDECREF(__pyx_t_19); __pyx_t_19 = 0;
      __Pyx_XDECREF(__pyx_t_20); __pyx_t_20 = 0;
      goto __pyx_L19_try_end;
      __pyx_L12_error:;
      __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
      __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
      __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
      __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
      __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
      __Pyx_XDECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1554
 *                             tmppeakset = []
 *                             break
 *             except StopIteration:             # <<<<<<<<<<<<<<
 *                 # no more strong (aka lvl1) peaks left
 *                 self.__add_broadpeak ( broadpeaks, chrom, lvl2, tmppeakset)
 */
      __Pyx_TraceLine(1554,0,__PYX_ERR(0, 1554, __pyx_L14_except_error))
      __pyx_t_17 = __Pyx_PyErr_ExceptionMatches(__pyx_builtin_StopIteration);
      if (__pyx_t_17) {
        __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.call_broadpeaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
        if (__Pyx_GetException(&__pyx_t_6, &__pyx_t_2, &__pyx_t_9) < 0) __PYX_ERR(0, 1554, __pyx_L14_except_error)
        __Pyx_GOTREF(__pyx_t_6);
        __Pyx_GOTREF(__pyx_t_2);
        __Pyx_GOTREF(__pyx_t_9);

        /* "MACS2/IO/CallPeakUnit.pyx":1556
 *             except StopIteration:
 *                 # no more strong (aka lvl1) peaks left
 *                 self.__add_broadpeak ( broadpeaks, chrom, lvl2, tmppeakset)             # <<<<<<<<<<<<<<
 *                 tmppeakset = []
 *                 # add the rest lvl2 peaks
 */
        __Pyx_TraceLine(1556,0,__PYX_ERR(0, 1556, __pyx_L14_except_error))
        if (unlikely(!__pyx_v_lvl2)) { __Pyx_RaiseUnboundLocalError("lvl2"); __PYX_ERR(0, 1556, __pyx_L14_except_error) }
        __pyx_t_5 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___add_broadpeak(__pyx_v_self, __pyx_v_broadpeaks, __pyx_v_chrom, __pyx_v_lvl2, __pyx_v_tmppeakset); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1556, __pyx_L14_except_error)
        __Pyx_GOTREF(__pyx_t_5);
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1557
 *                 # no more strong (aka lvl1) peaks left
 *                 self.__add_broadpeak ( broadpeaks, chrom, lvl2, tmppeakset)
 *                 tmppeakset = []             # <<<<<<<<<<<<<<
 *                 # add the rest lvl2 peaks
 *                 for j in range( i+1, len(lvl2peakschrom) ):
 */
        __Pyx_TraceLine(1557,0,__PYX_ERR(0, 1557, __pyx_L14_except_error))
        __pyx_t_5 = PyList_New(0); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1557, __pyx_L14_except_error)
        __Pyx_GOTREF(__pyx_t_5);
        __Pyx_DECREF_SET(__pyx_v_tmppeakset, ((PyObject*)__pyx_t_5));
        __pyx_t_5 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1559
 *                 tmppeakset = []
 *                 # add the rest lvl2 peaks
 *                 for j in range( i+1, len(lvl2peakschrom) ):             # <<<<<<<<<<<<<<
 *                     self.__add_broadpeak( broadpeaks, chrom, lvl2peakschrom[j], tmppeakset )
 * 
 */
        __Pyx_TraceLine(1559,0,__PYX_ERR(0, 1559, __pyx_L14_except_error))
        __pyx_t_21 = PyObject_Length(__pyx_v_lvl2peakschrom); if (unlikely(__pyx_t_21 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1559, __pyx_L14_except_error)
        __pyx_t_22 = __pyx_t_21;
        for (__pyx_t_23 = (__pyx_v_i + 1); __pyx_t_23 < __pyx_t_22; __pyx_t_23+=1) {
          __pyx_v_j = __pyx_t_23;

          /* "MACS2/IO/CallPeakUnit.pyx":1560
 *                 # add the rest lvl2 peaks
 *                 for j in range( i+1, len(lvl2peakschrom) ):
 *                     self.__add_broadpeak( broadpeaks, chrom, lvl2peakschrom[j], tmppeakset )             # <<<<<<<<<<<<<<
 * 
 *         return broadpeaks
 */
          __Pyx_TraceLine(1560,0,__PYX_ERR(0, 1560, __pyx_L14_except_error))
          __pyx_t_5 = __Pyx_GetItemInt(__pyx_v_lvl2peakschrom, __pyx_v_j, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1560, __pyx_L14_except_error)
          __Pyx_GOTREF(__pyx_t_5);
          __pyx_t_4 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___add_broadpeak(__pyx_v_self, __pyx_v_broadpeaks, __pyx_v_chrom, __pyx_t_5, __pyx_v_tmppeakset); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1560, __pyx_L14_except_error)
          __Pyx_GOTREF(__pyx_t_4);
          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        }
        __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
        __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
        __Pyx_XDECREF(__pyx_t_9); __pyx_t_9 = 0;
        goto __pyx_L13_exception_handled;
      }
      goto __pyx_L14_except_error;
      __pyx_L14_except_error:;

      /* "MACS2/IO/CallPeakUnit.pyx":1537
 *             tmppeakset = []             # to temporarily store lvl1 region inside a lvl2 region
 *             # our assumption is lvl1 regions should be included in lvl2 regions
 *             try:             # <<<<<<<<<<<<<<
 *                 lvl1 = lvl1peakschrom_next()
 *                 for i in range( len(lvl2peakschrom) ):
 */
      __Pyx_XGIVEREF(__pyx_t_18);
      __Pyx_XGIVEREF(__pyx_t_19);
      __Pyx_XGIVEREF(__pyx_t_20);
      __Pyx_ExceptionReset(__pyx_t_18, __pyx_t_19, __pyx_t_20);
      goto __pyx_L1_error;
      __pyx_L13_exception_handled:;
      __Pyx_XGIVEREF(__pyx_t_18);
      __Pyx_XGIVEREF(__pyx_t_19);
      __Pyx_XGIVEREF(__pyx_t_20);
      __Pyx_ExceptionReset(__pyx_t_18, __pyx_t_19, __pyx_t_20);
      __pyx_L19_try_end:;
    }
  }
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1562
 *                     self.__add_broadpeak( broadpeaks, chrom, lvl2peakschrom[j], tmppeakset )
 * 
 *         return broadpeaks             # <<<<<<<<<<<<<<
 * 
 *     cdef void  __chrom_call_broadpeak_using_certain_criteria ( self, lvl1peaks, lvl2peaks, bytes chrom, list scoring_function_s, list lvl1_cutoff_s, list lvl2_cutoff_s,
 */
  __Pyx_TraceLine(1562,0,__PYX_ERR(0, 1562, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_broadpeaks);
  __pyx_r = __pyx_v_broadpeaks;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1461
 *         return True
 * 
 *     cpdef call_broadpeaks (self, list scoring_function_symbols, list lvl1_cutoff_s, list lvl2_cutoff_s, int32_t min_length=200, int32_t lvl1_max_gap=50, int32_t lvl2_max_gap=400, bool cutoff_analysis = False):             # <<<<<<<<<<<<<<
 *         """This function try to find enriched regions within which,
 *         scores are continuously higher than a given cutoff for level
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_9);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.call_broadpeaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_chrom);
  __Pyx_XDECREF(__pyx_v_lvl1peaks);
  __Pyx_XDECREF(__pyx_v_lvl1peakschrom);
  __Pyx_XDECREF(__pyx_v_lvl1);
  __Pyx_XDECREF(__pyx_v_lvl2peaks);
  __Pyx_XDECREF(__pyx_v_lvl2peakschrom);
  __Pyx_XDECREF(__pyx_v_lvl2);
  __Pyx_XDECREF(__pyx_v_broadpeaks);
  __Pyx_XDECREF(__pyx_v_chrs);
  __Pyx_XDECREF(__pyx_v_tmppeakset);
  __Pyx_XDECREF(__pyx_v_tmp_bytes);
  __Pyx_XDECREF(__pyx_v_lvl1peakschrom_next);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_11call_broadpeaks(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static char __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_10call_broadpeaks[] = "This function try to find enriched regions within which,\n        scores are continuously higher than a given cutoff for level\n        1, and link them using the gap above level 2 cutoff with a\n        maximum length of lvl2_max_gap.\n\n        scoring_function_s: symbols of functions to calculate score. 'p' for pscore, 'q' for qscore, 'f' for fold change, 's' for subtraction. for example: ['p', 'q']\n\n        lvl1_cutoff_s:  list of cutoffs at highly enriched regions, corresponding to scoring functions.\n        lvl2_cutoff_s:  list of cutoffs at less enriched regions, corresponding to scoring functions.\n        min_length :    minimum peak length, default 200.\n        lvl1_max_gap   :  maximum gap to merge nearby enriched peaks, default 50.\n        lvl2_max_gap   :  maximum length of linkage regions, default 400.        \n\n        Return both general PeakIO object for highly enriched regions\n        and gapped broad regions in BroadPeakIO.\n        ";
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_11call_broadpeaks(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_scoring_function_symbols = 0;
  PyObject *__pyx_v_lvl1_cutoff_s = 0;
  PyObject *__pyx_v_lvl2_cutoff_s = 0;
  __pyx_t_5numpy_int32_t __pyx_v_min_length;
  __pyx_t_5numpy_int32_t __pyx_v_lvl1_max_gap;
  __pyx_t_5numpy_int32_t __pyx_v_lvl2_max_gap;
  PyBoolObject *__pyx_v_cutoff_analysis = 0;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("call_broadpeaks (wrapper)", 0);
  {
    static PyObject **__pyx_pyargnames[] = {&__pyx_n_s_scoring_function_symbols,&__pyx_n_s_lvl1_cutoff_s,&__pyx_n_s_lvl2_cutoff_s,&__pyx_n_s_min_length,&__pyx_n_s_lvl1_max_gap,&__pyx_n_s_lvl2_max_gap,&__pyx_n_s_cutoff_analysis,0};
    PyObject* values[7] = {0,0,0,0,0,0,0};
    values[6] = (PyObject *)((PyBoolObject *)Py_False);
    if (unlikely(__pyx_kwds)) {
      Py_ssize_t kw_args;
      const Py_ssize_t pos_args = PyTuple_GET_SIZE(__pyx_args);
      switch (pos_args) {
        case  7: values[6] = PyTuple_GET_ITEM(__pyx_args, 6);
        CYTHON_FALLTHROUGH;
        case  6: values[5] = PyTuple_GET_ITEM(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = PyTuple_GET_ITEM(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = PyDict_Size(__pyx_kwds);
      switch (pos_args) {
        case  0:
        if (likely((values[0] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_scoring_function_symbols)) != 0)) kw_args--;
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (likely((values[1] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_lvl1_cutoff_s)) != 0)) kw_args--;
        else {
          __Pyx_RaiseArgtupleInvalid("call_broadpeaks", 0, 3, 7, 1); __PYX_ERR(0, 1461, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (likely((values[2] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_lvl2_cutoff_s)) != 0)) kw_args--;
        else {
          __Pyx_RaiseArgtupleInvalid("call_broadpeaks", 0, 3, 7, 2); __PYX_ERR(0, 1461, __pyx_L3_error)
        }
        CYTHON_FALLTHROUGH;
        case  3:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_min_length);
          if (value) { values[3] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  4:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_lvl1_max_gap);
          if (value) { values[4] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  5:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_lvl2_max_gap);
          if (value) { values[5] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  6:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_cutoff_analysis);
          if (value) { values[6] = value; kw_args--; }
        }
      }
      if (unlikely(kw_args > 0)) {
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_pyargnames, 0, values, pos_args, "call_broadpeaks") < 0)) __PYX_ERR(0, 1461, __pyx_L3_error)
      }
    } else {
      switch (PyTuple_GET_SIZE(__pyx_args)) {
        case  7: values[6] = PyTuple_GET_ITEM(__pyx_args, 6);
        CYTHON_FALLTHROUGH;
        case  6: values[5] = PyTuple_GET_ITEM(__pyx_args, 5);
        CYTHON_FALLTHROUGH;
        case  5: values[4] = PyTuple_GET_ITEM(__pyx_args, 4);
        CYTHON_FALLTHROUGH;
        case  4: values[3] = PyTuple_GET_ITEM(__pyx_args, 3);
        CYTHON_FALLTHROUGH;
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_scoring_function_symbols = ((PyObject*)values[0]);
    __pyx_v_lvl1_cutoff_s = ((PyObject*)values[1]);
    __pyx_v_lvl2_cutoff_s = ((PyObject*)values[2]);
    if (values[3]) {
      __pyx_v_min_length = __Pyx_PyInt_As_npy_int32(values[3]); if (unlikely((__pyx_v_min_length == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1461, __pyx_L3_error)
    } else {
      __pyx_v_min_length = ((__pyx_t_5numpy_int32_t)0xC8);
    }
    if (values[4]) {
      __pyx_v_lvl1_max_gap = __Pyx_PyInt_As_npy_int32(values[4]); if (unlikely((__pyx_v_lvl1_max_gap == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1461, __pyx_L3_error)
    } else {
      __pyx_v_lvl1_max_gap = ((__pyx_t_5numpy_int32_t)50);
    }
    if (values[5]) {
      __pyx_v_lvl2_max_gap = __Pyx_PyInt_As_npy_int32(values[5]); if (unlikely((__pyx_v_lvl2_max_gap == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1461, __pyx_L3_error)
    } else {
      __pyx_v_lvl2_max_gap = ((__pyx_t_5numpy_int32_t)0x190);
    }
    __pyx_v_cutoff_analysis = ((PyBoolObject *)values[6]);
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("call_broadpeaks", 0, 3, 7, PyTuple_GET_SIZE(__pyx_args)); __PYX_ERR(0, 1461, __pyx_L3_error)
  __pyx_L3_error:;
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.call_broadpeaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_scoring_function_symbols), (&PyList_Type), 1, "scoring_function_symbols", 1))) __PYX_ERR(0, 1461, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_lvl1_cutoff_s), (&PyList_Type), 1, "lvl1_cutoff_s", 1))) __PYX_ERR(0, 1461, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_lvl2_cutoff_s), (&PyList_Type), 1, "lvl2_cutoff_s", 1))) __PYX_ERR(0, 1461, __pyx_L1_error)
  if (unlikely(!__Pyx_ArgTypeTest(((PyObject *)__pyx_v_cutoff_analysis), __pyx_ptype_7cpython_4bool_bool, 1, "cutoff_analysis", 0))) __PYX_ERR(0, 1461, __pyx_L1_error)
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_10call_broadpeaks(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self), __pyx_v_scoring_function_symbols, __pyx_v_lvl1_cutoff_s, __pyx_v_lvl2_cutoff_s, __pyx_v_min_length, __pyx_v_lvl1_max_gap, __pyx_v_lvl2_max_gap, __pyx_v_cutoff_analysis);

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_10call_broadpeaks(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_scoring_function_symbols, PyObject *__pyx_v_lvl1_cutoff_s, PyObject *__pyx_v_lvl2_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_lvl1_max_gap, __pyx_t_5numpy_int32_t __pyx_v_lvl2_max_gap, PyBoolObject *__pyx_v_cutoff_analysis) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks __pyx_t_2;
  __Pyx_RefNannySetupContext("call_broadpeaks", 0);
  __Pyx_TraceCall("call_broadpeaks (wrapper)", __pyx_f[0], 1461, 0, __PYX_ERR(0, 1461, __pyx_L1_error));
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_2.__pyx_n = 4;
  __pyx_t_2.min_length = __pyx_v_min_length;
  __pyx_t_2.lvl1_max_gap = __pyx_v_lvl1_max_gap;
  __pyx_t_2.lvl2_max_gap = __pyx_v_lvl2_max_gap;
  __pyx_t_2.cutoff_analysis = __pyx_v_cutoff_analysis;
  __pyx_t_1 = __pyx_vtabptr_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments->call_broadpeaks(__pyx_v_self, __pyx_v_scoring_function_symbols, __pyx_v_lvl1_cutoff_s, __pyx_v_lvl2_cutoff_s, 1, &__pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1461, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.call_broadpeaks", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1564
 *         return broadpeaks
 * 
 *     cdef void  __chrom_call_broadpeak_using_certain_criteria ( self, lvl1peaks, lvl2peaks, bytes chrom, list scoring_function_s, list lvl1_cutoff_s, list lvl2_cutoff_s,             # <<<<<<<<<<<<<<
 *                                                          int32_t min_length, int32_t lvl1_max_gap, int32_t lvl2_max_gap, bool save_bedGraph):
 *         """ Call peaks for a chromosome.
 */

static void __pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_call_broadpeak_using_certain_criteria(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_lvl1peaks, PyObject *__pyx_v_lvl2peaks, PyObject *__pyx_v_chrom, PyObject *__pyx_v_scoring_function_s, PyObject *__pyx_v_lvl1_cutoff_s, PyObject *__pyx_v_lvl2_cutoff_s, __pyx_t_5numpy_int32_t __pyx_v_min_length, __pyx_t_5numpy_int32_t __pyx_v_lvl1_max_gap, __pyx_t_5numpy_int32_t __pyx_v_lvl2_max_gap, PyBoolObject *__pyx_v_save_bedGraph) {
  __pyx_t_5numpy_int32_t __pyx_v_i;
  PyObject *__pyx_v_s = 0;
  PyArrayObject *__pyx_v_above_cutoff = 0;
  PyArrayObject *__pyx_v_above_cutoff_endpos = 0;
  PyArrayObject *__pyx_v_above_cutoff_startpos = 0;
  PyArrayObject *__pyx_v_pos_array = 0;
  PyArrayObject *__pyx_v_treat_array = 0;
  PyArrayObject *__pyx_v_ctrl_array = 0;
  PyArrayObject *__pyx_v_above_cutoff_index_array = 0;
  PyObject *__pyx_v_score_array_s = 0;
  PyObject *__pyx_v_peak_content = 0;
  __pyx_t_5numpy_int32_t *__pyx_v_acs_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_ace_ptr;
  __pyx_t_5numpy_int32_t *__pyx_v_acia_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_treat_array_ptr;
  __pyx_t_5numpy_float32_t *__pyx_v_ctrl_array_ptr;
  PyObject *__pyx_v_ts = NULL;
  __pyx_t_5numpy_int32_t __pyx_v_te;
  __pyx_t_5numpy_int32_t __pyx_v_ti;
  PyObject *__pyx_v_tp = NULL;
  PyObject *__pyx_v_cp = NULL;
  PyObject *__pyx_v_lastp = NULL;
  PyObject *__pyx_v_tl = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  Py_ssize_t __pyx_t_1;
  Py_ssize_t __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  int __pyx_t_7;
  __pyx_t_5numpy_int32_t __pyx_t_8;
  int __pyx_t_9;
  int __pyx_t_10;
  long __pyx_t_11;
  long __pyx_t_12;
  __Pyx_RefNannySetupContext("__chrom_call_broadpeak_using_certain_criteria", 0);
  __Pyx_TraceCall("__chrom_call_broadpeak_using_certain_criteria", __pyx_f[0], 1564, 0, __PYX_ERR(0, 1564, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":1588
 *             float32_t * ctrl_array_ptr
 * 
 *         assert len(scoring_function_s) == len(lvl1_cutoff_s), "number of functions and cutoffs should be the same!"             # <<<<<<<<<<<<<<
 *         assert len(scoring_function_s) == len(lvl2_cutoff_s), "number of functions and cutoffs should be the same!"
 * 
 */
  __Pyx_TraceLine(1588,0,__PYX_ERR(0, 1588, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(__pyx_v_scoring_function_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1588, __pyx_L1_error)
    }
    __pyx_t_1 = PyList_GET_SIZE(__pyx_v_scoring_function_s); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1588, __pyx_L1_error)
    if (unlikely(__pyx_v_lvl1_cutoff_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1588, __pyx_L1_error)
    }
    __pyx_t_2 = PyList_GET_SIZE(__pyx_v_lvl1_cutoff_s); if (unlikely(__pyx_t_2 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1588, __pyx_L1_error)
    if (unlikely(!((__pyx_t_1 == __pyx_t_2) != 0))) {
      PyErr_SetObject(PyExc_AssertionError, __pyx_kp_u_number_of_functions_and_cutoffs);
      __PYX_ERR(0, 1588, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1589
 * 
 *         assert len(scoring_function_s) == len(lvl1_cutoff_s), "number of functions and cutoffs should be the same!"
 *         assert len(scoring_function_s) == len(lvl2_cutoff_s), "number of functions and cutoffs should be the same!"             # <<<<<<<<<<<<<<
 * 
 *         # first, build pileup, self.chr_pos_treat_ctrl
 */
  __Pyx_TraceLine(1589,0,__PYX_ERR(0, 1589, __pyx_L1_error))
  #ifndef CYTHON_WITHOUT_ASSERTIONS
  if (unlikely(!Py_OptimizeFlag)) {
    if (unlikely(__pyx_v_scoring_function_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1589, __pyx_L1_error)
    }
    __pyx_t_2 = PyList_GET_SIZE(__pyx_v_scoring_function_s); if (unlikely(__pyx_t_2 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1589, __pyx_L1_error)
    if (unlikely(__pyx_v_lvl2_cutoff_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1589, __pyx_L1_error)
    }
    __pyx_t_1 = PyList_GET_SIZE(__pyx_v_lvl2_cutoff_s); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1589, __pyx_L1_error)
    if (unlikely(!((__pyx_t_2 == __pyx_t_1) != 0))) {
      PyErr_SetObject(PyExc_AssertionError, __pyx_kp_u_number_of_functions_and_cutoffs);
      __PYX_ERR(0, 1589, __pyx_L1_error)
    }
  }
  #endif

  /* "MACS2/IO/CallPeakUnit.pyx":1592
 * 
 *         # first, build pileup, self.chr_pos_treat_ctrl
 *         self.__pileup_treat_ctrl_a_chromosome( chrom )             # <<<<<<<<<<<<<<
 *         [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl
 * 
 */
  __Pyx_TraceLine(1592,0,__PYX_ERR(0, 1592, __pyx_L1_error))
  __pyx_t_3 = ((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___pileup_treat_ctrl_a_chromosome(__pyx_v_self, __pyx_v_chrom); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1592, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1593
 *         # first, build pileup, self.chr_pos_treat_ctrl
 *         self.__pileup_treat_ctrl_a_chromosome( chrom )
 *         [pos_array, treat_array, ctrl_array] = self.chr_pos_treat_ctrl             # <<<<<<<<<<<<<<
 * 
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 */
  __Pyx_TraceLine(1593,0,__PYX_ERR(0, 1593, __pyx_L1_error))
  __pyx_t_3 = __pyx_v_self->chr_pos_treat_ctrl;
  __Pyx_INCREF(__pyx_t_3);
  if (likely(__pyx_t_3 != Py_None)) {
    PyObject* sequence = __pyx_t_3;
    Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
    if (unlikely(size != 3)) {
      if (size > 3) __Pyx_RaiseTooManyValuesError(3);
      else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
      __PYX_ERR(0, 1593, __pyx_L1_error)
    }
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_4 = PyList_GET_ITEM(sequence, 0); 
    __pyx_t_5 = PyList_GET_ITEM(sequence, 1); 
    __pyx_t_6 = PyList_GET_ITEM(sequence, 2); 
    __Pyx_INCREF(__pyx_t_4);
    __Pyx_INCREF(__pyx_t_5);
    __Pyx_INCREF(__pyx_t_6);
    #else
    __pyx_t_4 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1593, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_5 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1593, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = PySequence_ITEM(sequence, 2); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1593, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    #endif
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  } else {
    __Pyx_RaiseNoneNotIterableError(); __PYX_ERR(0, 1593, __pyx_L1_error)
  }
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1593, __pyx_L1_error)
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1593, __pyx_L1_error)
  if (!(likely(((__pyx_t_6) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_6, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1593, __pyx_L1_error)
  __pyx_v_pos_array = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;
  __pyx_v_treat_array = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;
  __pyx_v_ctrl_array = ((PyArrayObject *)__pyx_t_6);
  __pyx_t_6 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1596
 * 
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 *         if save_bedGraph:             # <<<<<<<<<<<<<<
 *             self.__write_bedGraph_for_a_chromosome ( chrom )
 * 
 */
  __Pyx_TraceLine(1596,0,__PYX_ERR(0, 1596, __pyx_L1_error))
  __pyx_t_7 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_save_bedGraph)); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1596, __pyx_L1_error)
  if (__pyx_t_7) {

    /* "MACS2/IO/CallPeakUnit.pyx":1597
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 *         if save_bedGraph:
 *             self.__write_bedGraph_for_a_chromosome ( chrom )             # <<<<<<<<<<<<<<
 * 
 *         # keep all types of scores needed
 */
    __Pyx_TraceLine(1597,0,__PYX_ERR(0, 1597, __pyx_L1_error))
    __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___write_bedGraph_for_a_chromosome(__pyx_v_self, __pyx_v_chrom)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1597, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1596
 * 
 *         # while save_bedGraph is true, invoke __write_bedGraph_for_a_chromosome
 *         if save_bedGraph:             # <<<<<<<<<<<<<<
 *             self.__write_bedGraph_for_a_chromosome ( chrom )
 * 
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1600
 * 
 *         # keep all types of scores needed
 *         score_array_s = []             # <<<<<<<<<<<<<<
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]
 */
  __Pyx_TraceLine(1600,0,__PYX_ERR(0, 1600, __pyx_L1_error))
  __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1600, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_v_score_array_s = ((PyObject*)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1601
 *         # keep all types of scores needed
 *         score_array_s = []
 *         for i in range(len(scoring_function_s)):             # <<<<<<<<<<<<<<
 *             s = scoring_function_s[i]
 *             if s == 'p':
 */
  __Pyx_TraceLine(1601,0,__PYX_ERR(0, 1601, __pyx_L1_error))
  if (unlikely(__pyx_v_scoring_function_s == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 1601, __pyx_L1_error)
  }
  __pyx_t_1 = PyList_GET_SIZE(__pyx_v_scoring_function_s); if (unlikely(__pyx_t_1 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1601, __pyx_L1_error)
  __pyx_t_2 = __pyx_t_1;
  for (__pyx_t_8 = 0; __pyx_t_8 < __pyx_t_2; __pyx_t_8+=1) {
    __pyx_v_i = __pyx_t_8;

    /* "MACS2/IO/CallPeakUnit.pyx":1602
 *         score_array_s = []
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]             # <<<<<<<<<<<<<<
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 */
    __Pyx_TraceLine(1602,0,__PYX_ERR(0, 1602, __pyx_L1_error))
    if (unlikely(__pyx_v_scoring_function_s == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1602, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_scoring_function_s, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1602, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    if (!(likely(PyUnicode_CheckExact(__pyx_t_3))||((__pyx_t_3) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "unicode", Py_TYPE(__pyx_t_3)->tp_name), 0))) __PYX_ERR(0, 1602, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_s, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1603
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]
 *             if s == 'p':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':
 */
    __Pyx_TraceLine(1603,0,__PYX_ERR(0, 1603, __pyx_L1_error))
    __pyx_t_7 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_p, Py_EQ)); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1603, __pyx_L1_error)
    __pyx_t_9 = (__pyx_t_7 != 0);
    if (__pyx_t_9) {

      /* "MACS2/IO/CallPeakUnit.pyx":1604
 *             s = scoring_function_s[i]
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 */
      __Pyx_TraceLine(1604,0,__PYX_ERR(0, 1604, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_pscore(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1604, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1604, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1603
 *         for i in range(len(scoring_function_s)):
 *             s = scoring_function_s[i]
 *             if s == 'p':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1605
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':
 */
    __Pyx_TraceLine(1605,0,__PYX_ERR(0, 1605, __pyx_L1_error))
    __pyx_t_9 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_q, Py_EQ)); if (unlikely(__pyx_t_9 < 0)) __PYX_ERR(0, 1605, __pyx_L1_error)
    __pyx_t_7 = (__pyx_t_9 != 0);
    if (__pyx_t_7) {

      /* "MACS2/IO/CallPeakUnit.pyx":1606
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 */
      __Pyx_TraceLine(1606,0,__PYX_ERR(0, 1606, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_qscore(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1606, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1606, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1605
 *             if s == 'p':
 *                 score_array_s.append( self.__cal_pscore( treat_array, ctrl_array ) )
 *             elif s == 'q':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1607
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':
 */
    __Pyx_TraceLine(1607,0,__PYX_ERR(0, 1607, __pyx_L1_error))
    __pyx_t_7 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_f, Py_EQ)); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1607, __pyx_L1_error)
    __pyx_t_9 = (__pyx_t_7 != 0);
    if (__pyx_t_9) {

      /* "MACS2/IO/CallPeakUnit.pyx":1608
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 *             elif s == 's':
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )
 */
      __Pyx_TraceLine(1608,0,__PYX_ERR(0, 1608, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_FE(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1608, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1608, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1607
 *             elif s == 'q':
 *                 score_array_s.append( self.__cal_qscore( treat_array, ctrl_array ) )
 *             elif s == 'f':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':
 */
      goto __pyx_L6;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1609
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )
 * 
 */
    __Pyx_TraceLine(1609,0,__PYX_ERR(0, 1609, __pyx_L1_error))
    __pyx_t_9 = (__Pyx_PyUnicode_Equals(__pyx_v_s, __pyx_n_u_s, Py_EQ)); if (unlikely(__pyx_t_9 < 0)) __PYX_ERR(0, 1609, __pyx_L1_error)
    __pyx_t_7 = (__pyx_t_9 != 0);
    if (__pyx_t_7) {

      /* "MACS2/IO/CallPeakUnit.pyx":1610
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )             # <<<<<<<<<<<<<<
 * 
 *         # lvl1 : strong peaks
 */
      __Pyx_TraceLine(1610,0,__PYX_ERR(0, 1610, __pyx_L1_error))
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_subtraction(__pyx_v_self, ((PyArrayObject *)__pyx_v_treat_array), ((PyArrayObject *)__pyx_v_ctrl_array))); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1610, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_score_array_s, __pyx_t_3); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1610, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1609
 *             elif s == 'f':
 *                 score_array_s.append( self.__cal_FE( treat_array, ctrl_array ) )
 *             elif s == 's':             # <<<<<<<<<<<<<<
 *                 score_array_s.append( self.__cal_subtraction( treat_array, ctrl_array ) )
 * 
 */
    }
    __pyx_L6:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1613
 * 
 *         # lvl1 : strong peaks
 *         peak_content = []           # to store points above cutoff             # <<<<<<<<<<<<<<
 * 
 *         # get the regions with scores above cutoffs
 */
  __Pyx_TraceLine(1613,0,__PYX_ERR(0, 1613, __pyx_L1_error))
  __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1613, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_v_peak_content = ((PyObject*)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1616
 * 
 *         # get the regions with scores above cutoffs
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,lvl1_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?             # <<<<<<<<<<<<<<
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 */
  __Pyx_TraceLine(1616,0,__PYX_ERR(0, 1616, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_6, __pyx_n_s_np); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1616, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_6, __pyx_n_s_nonzero); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1616, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_6 = ((PyObject *)__pyx_f_5MACS2_2IO_12CallPeakUnit_apply_multiple_cutoffs(__pyx_v_score_array_s, __pyx_v_lvl1_cutoff_s)); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1616, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_4 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_4 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_4)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_4);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_3 = (__pyx_t_4) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_4, __pyx_t_6) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_6);
  __Pyx_XDECREF(__pyx_t_4); __pyx_t_4 = 0;
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1616, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_GetItemInt(__pyx_t_3, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1616, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1616, __pyx_L1_error)
  __pyx_v_above_cutoff = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1617
 *         # get the regions with scores above cutoffs
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,lvl1_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices             # <<<<<<<<<<<<<<
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 */
  __Pyx_TraceLine(1617,0,__PYX_ERR(0, 1617, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_np); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1617, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_arange); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1617, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_pos_array->dimensions[0])); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1617, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = PyTuple_New(1); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1617, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_GIVEREF(__pyx_t_5);
  PyTuple_SET_ITEM(__pyx_t_6, 0, __pyx_t_5);
  __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1617, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  if (PyDict_SetItem(__pyx_t_5, __pyx_n_s_dtype, __pyx_n_u_int32) < 0) __PYX_ERR(0, 1617, __pyx_L1_error)
  __pyx_t_4 = __Pyx_PyObject_Call(__pyx_t_3, __pyx_t_6, __pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1617, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = __Pyx_PyObject_GetItem(__pyx_t_4, ((PyObject *)__pyx_v_above_cutoff)); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1617, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1617, __pyx_L1_error)
  __pyx_v_above_cutoff_index_array = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1618
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,lvl1_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 */
  __Pyx_TraceLine(1618,0,__PYX_ERR(0, 1618, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), ((PyObject *)__pyx_v_above_cutoff)); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1618, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1618, __pyx_L1_error)
  __pyx_v_above_cutoff_endpos = ((PyArrayObject *)__pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1619
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 * 
 *         if above_cutoff.size == 0:
 */
  __Pyx_TraceLine(1619,0,__PYX_ERR(0, 1619, __pyx_L1_error))
  __pyx_t_5 = PyNumber_Subtract(((PyObject *)__pyx_v_above_cutoff), __pyx_int_1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1619, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_4 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), __pyx_t_5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1619, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1619, __pyx_L1_error)
  __pyx_v_above_cutoff_startpos = ((PyArrayObject *)__pyx_t_4);
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1621
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *         if above_cutoff.size == 0:             # <<<<<<<<<<<<<<
 *             # nothing above cutoff
 *             return
 */
  __Pyx_TraceLine(1621,0,__PYX_ERR(0, 1621, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_above_cutoff), __pyx_n_s_size); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1621, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_5 = __Pyx_PyInt_EqObjC(__pyx_t_4, __pyx_int_0, 0, 0); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1621, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1621, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (__pyx_t_7) {

    /* "MACS2/IO/CallPeakUnit.pyx":1623
 *         if above_cutoff.size == 0:
 *             # nothing above cutoff
 *             return             # <<<<<<<<<<<<<<
 * 
 *         if above_cutoff[0] == 0:
 */
    __Pyx_TraceLine(1623,0,__PYX_ERR(0, 1623, __pyx_L1_error))
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1621
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *         if above_cutoff.size == 0:             # <<<<<<<<<<<<<<
 *             # nothing above cutoff
 *             return
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1625
 *             return
 * 
 *         if above_cutoff[0] == 0:             # <<<<<<<<<<<<<<
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0
 */
  __Pyx_TraceLine(1625,0,__PYX_ERR(0, 1625, __pyx_L1_error))
  __pyx_t_5 = __Pyx_GetItemInt(((PyObject *)__pyx_v_above_cutoff), 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1625, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_4 = __Pyx_PyInt_EqObjC(__pyx_t_5, __pyx_int_0, 0, 0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1625, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1625, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (__pyx_t_7) {

    /* "MACS2/IO/CallPeakUnit.pyx":1627
 *         if above_cutoff[0] == 0:
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0             # <<<<<<<<<<<<<<
 * 
 *         # first bit of region above cutoff
 */
    __Pyx_TraceLine(1627,0,__PYX_ERR(0, 1627, __pyx_L1_error))
    if (unlikely(__Pyx_SetItemInt(((PyObject *)__pyx_v_above_cutoff_startpos), 0, __pyx_int_0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1) < 0)) __PYX_ERR(0, 1627, __pyx_L1_error)

    /* "MACS2/IO/CallPeakUnit.pyx":1625
 *             return
 * 
 *         if above_cutoff[0] == 0:             # <<<<<<<<<<<<<<
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1630
 * 
 *         # first bit of region above cutoff
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data             # <<<<<<<<<<<<<<
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 */
  __Pyx_TraceLine(1630,0,__PYX_ERR(0, 1630, __pyx_L1_error))
  __pyx_v_acs_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_startpos->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1631
 *         # first bit of region above cutoff
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data             # <<<<<<<<<<<<<<
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 */
  __Pyx_TraceLine(1631,0,__PYX_ERR(0, 1631, __pyx_L1_error))
  __pyx_v_ace_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_endpos->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1632
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data             # <<<<<<<<<<<<<<
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 */
  __Pyx_TraceLine(1632,0,__PYX_ERR(0, 1632, __pyx_L1_error))
  __pyx_v_acia_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_index_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1633
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data             # <<<<<<<<<<<<<<
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 */
  __Pyx_TraceLine(1633,0,__PYX_ERR(0, 1633, __pyx_L1_error))
  __pyx_v_treat_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_treat_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1634
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data             # <<<<<<<<<<<<<<
 * 
 *         ts = acs_ptr[ 0 ]
 */
  __Pyx_TraceLine(1634,0,__PYX_ERR(0, 1634, __pyx_L1_error))
  __pyx_v_ctrl_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_ctrl_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1636
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 *         ts = acs_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]
 */
  __Pyx_TraceLine(1636,0,__PYX_ERR(0, 1636, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1636, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_v_ts = __pyx_t_4;
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1637
 * 
 *         ts = acs_ptr[ 0 ]
 *         te = ace_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]
 */
  __Pyx_TraceLine(1637,0,__PYX_ERR(0, 1637, __pyx_L1_error))
  __pyx_v_te = (__pyx_v_ace_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1638
 *         ts = acs_ptr[ 0 ]
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         tp = treat_array_ptr[ ti ]
 *         cp = ctrl_array_ptr[ ti ]
 */
  __Pyx_TraceLine(1638,0,__PYX_ERR(0, 1638, __pyx_L1_error))
  __pyx_v_ti = (__pyx_v_acia_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1639
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *         cp = ctrl_array_ptr[ ti ]
 * 
 */
  __Pyx_TraceLine(1639,0,__PYX_ERR(0, 1639, __pyx_L1_error))
  __pyx_t_4 = PyFloat_FromDouble((__pyx_v_treat_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1639, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_v_tp = __pyx_t_4;
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1640
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]
 *         cp = ctrl_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 * 
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 */
  __Pyx_TraceLine(1640,0,__PYX_ERR(0, 1640, __pyx_L1_error))
  __pyx_t_4 = PyFloat_FromDouble((__pyx_v_ctrl_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1640, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_v_cp = __pyx_t_4;
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1642
 *         cp = ctrl_array_ptr[ ti ]
 * 
 *         peak_content.append( ( ts, te, tp, cp, ti ) )             # <<<<<<<<<<<<<<
 *         acs_ptr += 1 # move ptr
 *         ace_ptr += 1
 */
  __Pyx_TraceLine(1642,0,__PYX_ERR(0, 1642, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_ti); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_6 = PyTuple_New(5); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1642, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_INCREF(__pyx_v_ts);
  __Pyx_GIVEREF(__pyx_v_ts);
  PyTuple_SET_ITEM(__pyx_t_6, 0, __pyx_v_ts);
  __Pyx_GIVEREF(__pyx_t_4);
  PyTuple_SET_ITEM(__pyx_t_6, 1, __pyx_t_4);
  __Pyx_INCREF(__pyx_v_tp);
  __Pyx_GIVEREF(__pyx_v_tp);
  PyTuple_SET_ITEM(__pyx_t_6, 2, __pyx_v_tp);
  __Pyx_INCREF(__pyx_v_cp);
  __Pyx_GIVEREF(__pyx_v_cp);
  PyTuple_SET_ITEM(__pyx_t_6, 3, __pyx_v_cp);
  __Pyx_GIVEREF(__pyx_t_5);
  PyTuple_SET_ITEM(__pyx_t_6, 4, __pyx_t_5);
  __pyx_t_4 = 0;
  __pyx_t_5 = 0;
  __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_peak_content, __pyx_t_6); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1642, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1643
 * 
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 *         acs_ptr += 1 # move ptr             # <<<<<<<<<<<<<<
 *         ace_ptr += 1
 *         acia_ptr+= 1
 */
  __Pyx_TraceLine(1643,0,__PYX_ERR(0, 1643, __pyx_L1_error))
  __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1644
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 *         acs_ptr += 1 # move ptr
 *         ace_ptr += 1             # <<<<<<<<<<<<<<
 *         acia_ptr+= 1
 *         lastp = te
 */
  __Pyx_TraceLine(1644,0,__PYX_ERR(0, 1644, __pyx_L1_error))
  __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1645
 *         acs_ptr += 1 # move ptr
 *         ace_ptr += 1
 *         acia_ptr+= 1             # <<<<<<<<<<<<<<
 *         lastp = te
 * 
 */
  __Pyx_TraceLine(1645,0,__PYX_ERR(0, 1645, __pyx_L1_error))
  __pyx_v_acia_ptr = (__pyx_v_acia_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1646
 *         ace_ptr += 1
 *         acia_ptr+= 1
 *         lastp = te             # <<<<<<<<<<<<<<
 * 
 *         #peak_content.append( (above_cutoff_startpos[0], above_cutoff_endpos[0], treat_array[above_cutoff_index_array[0]], ctrl_array[above_cutoff_index_array[0]], score_array_s, above_cutoff_index_array[0] ) )
 */
  __Pyx_TraceLine(1646,0,__PYX_ERR(0, 1646, __pyx_L1_error))
  __pyx_t_6 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1646, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_v_lastp = __pyx_t_6;
  __pyx_t_6 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1649
 * 
 *         #peak_content.append( (above_cutoff_startpos[0], above_cutoff_endpos[0], treat_array[above_cutoff_index_array[0]], ctrl_array[above_cutoff_index_array[0]], score_array_s, above_cutoff_index_array[0] ) )
 *         for i in range( 1, above_cutoff_startpos.size ):             # <<<<<<<<<<<<<<
 *             ts = acs_ptr[ 0 ]
 *             te = ace_ptr[ 0 ]
 */
  __Pyx_TraceLine(1649,0,__PYX_ERR(0, 1649, __pyx_L1_error))
  __pyx_t_6 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_above_cutoff_startpos), __pyx_n_s_size); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1649, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_11 = __Pyx_PyInt_As_long(__pyx_t_6); if (unlikely((__pyx_t_11 == (long)-1) && PyErr_Occurred())) __PYX_ERR(0, 1649, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_t_12 = __pyx_t_11;
  for (__pyx_t_8 = 1; __pyx_t_8 < __pyx_t_12; __pyx_t_8+=1) {
    __pyx_v_i = __pyx_t_8;

    /* "MACS2/IO/CallPeakUnit.pyx":1650
 *         #peak_content.append( (above_cutoff_startpos[0], above_cutoff_endpos[0], treat_array[above_cutoff_index_array[0]], ctrl_array[above_cutoff_index_array[0]], score_array_s, above_cutoff_index_array[0] ) )
 *         for i in range( 1, above_cutoff_startpos.size ):
 *             ts = acs_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *             te = ace_ptr[ 0 ]
 *             ti = acia_ptr[ 0 ]
 */
    __Pyx_TraceLine(1650,0,__PYX_ERR(0, 1650, __pyx_L1_error))
    __pyx_t_6 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1650, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF_SET(__pyx_v_ts, __pyx_t_6);
    __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1651
 *         for i in range( 1, above_cutoff_startpos.size ):
 *             ts = acs_ptr[ 0 ]
 *             te = ace_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *             ti = acia_ptr[ 0 ]
 *             acs_ptr += 1
 */
    __Pyx_TraceLine(1651,0,__PYX_ERR(0, 1651, __pyx_L1_error))
    __pyx_v_te = (__pyx_v_ace_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1652
 *             ts = acs_ptr[ 0 ]
 *             te = ace_ptr[ 0 ]
 *             ti = acia_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *             acs_ptr += 1
 *             ace_ptr += 1
 */
    __Pyx_TraceLine(1652,0,__PYX_ERR(0, 1652, __pyx_L1_error))
    __pyx_v_ti = (__pyx_v_acia_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1653
 *             te = ace_ptr[ 0 ]
 *             ti = acia_ptr[ 0 ]
 *             acs_ptr += 1             # <<<<<<<<<<<<<<
 *             ace_ptr += 1
 *             acia_ptr+= 1
 */
    __Pyx_TraceLine(1653,0,__PYX_ERR(0, 1653, __pyx_L1_error))
    __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1654
 *             ti = acia_ptr[ 0 ]
 *             acs_ptr += 1
 *             ace_ptr += 1             # <<<<<<<<<<<<<<
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ]
 */
    __Pyx_TraceLine(1654,0,__PYX_ERR(0, 1654, __pyx_L1_error))
    __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1655
 *             acs_ptr += 1
 *             ace_ptr += 1
 *             acia_ptr+= 1             # <<<<<<<<<<<<<<
 *             tp = treat_array_ptr[ ti ]
 *             cp = ctrl_array_ptr[ ti ]
 */
    __Pyx_TraceLine(1655,0,__PYX_ERR(0, 1655, __pyx_L1_error))
    __pyx_v_acia_ptr = (__pyx_v_acia_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1656
 *             ace_ptr += 1
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp
 */
    __Pyx_TraceLine(1656,0,__PYX_ERR(0, 1656, __pyx_L1_error))
    __pyx_t_6 = PyFloat_FromDouble((__pyx_v_treat_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1656, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF_SET(__pyx_v_tp, __pyx_t_6);
    __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1657
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ]
 *             cp = ctrl_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *             tl = ts - lastp
 *             if tl <= lvl1_max_gap:
 */
    __Pyx_TraceLine(1657,0,__PYX_ERR(0, 1657, __pyx_L1_error))
    __pyx_t_6 = PyFloat_FromDouble((__pyx_v_ctrl_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1657, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF_SET(__pyx_v_cp, __pyx_t_6);
    __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1658
 *             tp = treat_array_ptr[ ti ]
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp             # <<<<<<<<<<<<<<
 *             if tl <= lvl1_max_gap:
 *                 # append
 */
    __Pyx_TraceLine(1658,0,__PYX_ERR(0, 1658, __pyx_L1_error))
    __pyx_t_6 = PyNumber_Subtract(__pyx_v_ts, __pyx_v_lastp); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1658, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_XDECREF_SET(__pyx_v_tl, __pyx_t_6);
    __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1659
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp
 *             if tl <= lvl1_max_gap:             # <<<<<<<<<<<<<<
 *                 # append
 *                 #peak_content.append( (above_cutoff_startpos[i], above_cutoff_endpos[i], treat_array[above_cutoff_index_array[i]], ctrl_array[above_cutoff_index_array[i]], score_array_s, above_cutoff_index_array[i] ) )
 */
    __Pyx_TraceLine(1659,0,__PYX_ERR(0, 1659, __pyx_L1_error))
    __pyx_t_6 = __Pyx_PyInt_From_npy_int32(__pyx_v_lvl1_max_gap); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1659, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_5 = PyObject_RichCompare(__pyx_v_tl, __pyx_t_6, Py_LE); __Pyx_XGOTREF(__pyx_t_5); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1659, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_5); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1659, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (__pyx_t_7) {

      /* "MACS2/IO/CallPeakUnit.pyx":1662
 *                 # append
 *                 #peak_content.append( (above_cutoff_startpos[i], above_cutoff_endpos[i], treat_array[above_cutoff_index_array[i]], ctrl_array[above_cutoff_index_array[i]], score_array_s, above_cutoff_index_array[i] ) )
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )             # <<<<<<<<<<<<<<
 *                 lastp = te
 *             else:
 */
      __Pyx_TraceLine(1662,0,__PYX_ERR(0, 1662, __pyx_L1_error))
      __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1662, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_6 = __Pyx_PyInt_From_npy_int32(__pyx_v_ti); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1662, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __pyx_t_4 = PyTuple_New(5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1662, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_INCREF(__pyx_v_ts);
      __Pyx_GIVEREF(__pyx_v_ts);
      PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_v_ts);
      __Pyx_GIVEREF(__pyx_t_5);
      PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_5);
      __Pyx_INCREF(__pyx_v_tp);
      __Pyx_GIVEREF(__pyx_v_tp);
      PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_tp);
      __Pyx_INCREF(__pyx_v_cp);
      __Pyx_GIVEREF(__pyx_v_cp);
      PyTuple_SET_ITEM(__pyx_t_4, 3, __pyx_v_cp);
      __Pyx_GIVEREF(__pyx_t_6);
      PyTuple_SET_ITEM(__pyx_t_4, 4, __pyx_t_6);
      __pyx_t_5 = 0;
      __pyx_t_6 = 0;
      __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_peak_content, __pyx_t_4); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1662, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1663
 *                 #peak_content.append( (above_cutoff_startpos[i], above_cutoff_endpos[i], treat_array[above_cutoff_index_array[i]], ctrl_array[above_cutoff_index_array[i]], score_array_s, above_cutoff_index_array[i] ) )
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )
 *                 lastp = te             # <<<<<<<<<<<<<<
 *             else:
 *                 # close
 */
      __Pyx_TraceLine(1663,0,__PYX_ERR(0, 1663, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1663, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF_SET(__pyx_v_lastp, __pyx_t_4);
      __pyx_t_4 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1659
 *             cp = ctrl_array_ptr[ ti ]
 *             tl = ts - lastp
 *             if tl <= lvl1_max_gap:             # <<<<<<<<<<<<<<
 *                 # append
 *                 #peak_content.append( (above_cutoff_startpos[i], above_cutoff_endpos[i], treat_array[above_cutoff_index_array[i]], ctrl_array[above_cutoff_index_array[i]], score_array_s, above_cutoff_index_array[i] ) )
 */
      goto __pyx_L11;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1666
 *             else:
 *                 # close
 *                 self.__close_peak_for_broad_region (peak_content, lvl1peaks, min_length, chrom, lvl1_max_gap//2, score_array_s )             # <<<<<<<<<<<<<<
 *                 #peak_content = [ (above_cutoff_startpos[i], above_cutoff_endpos[i], treat_array[above_cutoff_index_array[i]], ctrl_array[above_cutoff_index_array[i]], score_array_s, above_cutoff_index_array[i]) , ]
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]
 */
    __Pyx_TraceLine(1666,0,__PYX_ERR(0, 1666, __pyx_L1_error))
    /*else*/ {
      __pyx_t_4 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_for_broad_region(__pyx_v_self, __pyx_v_peak_content, __pyx_v_lvl1peaks, __pyx_v_min_length, __pyx_v_chrom, __Pyx_div_long(__pyx_v_lvl1_max_gap, 2), __pyx_v_score_array_s, NULL)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1666, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1668
 *                 self.__close_peak_for_broad_region (peak_content, lvl1peaks, min_length, chrom, lvl1_max_gap//2, score_array_s )
 *                 #peak_content = [ (above_cutoff_startpos[i], above_cutoff_endpos[i], treat_array[above_cutoff_index_array[i]], ctrl_array[above_cutoff_index_array[i]], score_array_s, above_cutoff_index_array[i]) , ]
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]             # <<<<<<<<<<<<<<
 *                 lastp = te #above_cutoff_endpos[i]
 * 
 */
      __Pyx_TraceLine(1668,0,__PYX_ERR(0, 1668, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1668, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_6 = __Pyx_PyInt_From_npy_int32(__pyx_v_ti); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1668, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __pyx_t_5 = PyTuple_New(5); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1668, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_INCREF(__pyx_v_ts);
      __Pyx_GIVEREF(__pyx_v_ts);
      PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_v_ts);
      __Pyx_GIVEREF(__pyx_t_4);
      PyTuple_SET_ITEM(__pyx_t_5, 1, __pyx_t_4);
      __Pyx_INCREF(__pyx_v_tp);
      __Pyx_GIVEREF(__pyx_v_tp);
      PyTuple_SET_ITEM(__pyx_t_5, 2, __pyx_v_tp);
      __Pyx_INCREF(__pyx_v_cp);
      __Pyx_GIVEREF(__pyx_v_cp);
      PyTuple_SET_ITEM(__pyx_t_5, 3, __pyx_v_cp);
      __Pyx_GIVEREF(__pyx_t_6);
      PyTuple_SET_ITEM(__pyx_t_5, 4, __pyx_t_6);
      __pyx_t_4 = 0;
      __pyx_t_6 = 0;
      __pyx_t_6 = PyList_New(1); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1668, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __Pyx_GIVEREF(__pyx_t_5);
      PyList_SET_ITEM(__pyx_t_6, 0, __pyx_t_5);
      __pyx_t_5 = 0;
      __Pyx_DECREF_SET(__pyx_v_peak_content, ((PyObject*)__pyx_t_6));
      __pyx_t_6 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1669
 *                 #peak_content = [ (above_cutoff_startpos[i], above_cutoff_endpos[i], treat_array[above_cutoff_index_array[i]], ctrl_array[above_cutoff_index_array[i]], score_array_s, above_cutoff_index_array[i]) , ]
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]
 *                 lastp = te #above_cutoff_endpos[i]             # <<<<<<<<<<<<<<
 * 
 *         # save the last peak
 */
      __Pyx_TraceLine(1669,0,__PYX_ERR(0, 1669, __pyx_L1_error))
      __pyx_t_6 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1669, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_6);
      __Pyx_DECREF_SET(__pyx_v_lastp, __pyx_t_6);
      __pyx_t_6 = 0;
    }
    __pyx_L11:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1672
 * 
 *         # save the last peak
 *         if peak_content:             # <<<<<<<<<<<<<<
 *             self.__close_peak_for_broad_region (peak_content, lvl1peaks, min_length, chrom, lvl1_max_gap//2, score_array_s )
 * 
 */
  __Pyx_TraceLine(1672,0,__PYX_ERR(0, 1672, __pyx_L1_error))
  __pyx_t_7 = (PyList_GET_SIZE(__pyx_v_peak_content) != 0);
  if (__pyx_t_7) {

    /* "MACS2/IO/CallPeakUnit.pyx":1673
 *         # save the last peak
 *         if peak_content:
 *             self.__close_peak_for_broad_region (peak_content, lvl1peaks, min_length, chrom, lvl1_max_gap//2, score_array_s )             # <<<<<<<<<<<<<<
 * 
 *         # lvl2 : weak peaks
 */
    __Pyx_TraceLine(1673,0,__PYX_ERR(0, 1673, __pyx_L1_error))
    __pyx_t_6 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_for_broad_region(__pyx_v_self, __pyx_v_peak_content, __pyx_v_lvl1peaks, __pyx_v_min_length, __pyx_v_chrom, __Pyx_div_long(__pyx_v_lvl1_max_gap, 2), __pyx_v_score_array_s, NULL)); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1673, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1672
 * 
 *         # save the last peak
 *         if peak_content:             # <<<<<<<<<<<<<<
 *             self.__close_peak_for_broad_region (peak_content, lvl1peaks, min_length, chrom, lvl1_max_gap//2, score_array_s )
 * 
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1676
 * 
 *         # lvl2 : weak peaks
 *         peak_content = []           # to store points above cutoff             # <<<<<<<<<<<<<<
 * 
 *         # get the regions with scores above cutoffs
 */
  __Pyx_TraceLine(1676,0,__PYX_ERR(0, 1676, __pyx_L1_error))
  __pyx_t_6 = PyList_New(0); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1676, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF_SET(__pyx_v_peak_content, ((PyObject*)__pyx_t_6));
  __pyx_t_6 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1679
 * 
 *         # get the regions with scores above cutoffs
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,lvl2_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?             # <<<<<<<<<<<<<<
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 */
  __Pyx_TraceLine(1679,0,__PYX_ERR(0, 1679, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_np); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1679, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_4 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_nonzero); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1679, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = ((PyObject *)__pyx_f_5MACS2_2IO_12CallPeakUnit_apply_multiple_cutoffs(__pyx_v_score_array_s, __pyx_v_lvl2_cutoff_s)); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1679, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_3 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_4))) {
    __pyx_t_3 = PyMethod_GET_SELF(__pyx_t_4);
    if (likely(__pyx_t_3)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_4);
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_4, function);
    }
  }
  __pyx_t_6 = (__pyx_t_3) ? __Pyx_PyObject_Call2Args(__pyx_t_4, __pyx_t_3, __pyx_t_5) : __Pyx_PyObject_CallOneArg(__pyx_t_4, __pyx_t_5);
  __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1679, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_4 = __Pyx_GetItemInt(__pyx_t_6, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1679, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1679, __pyx_L1_error)
  __Pyx_DECREF_SET(__pyx_v_above_cutoff, ((PyArrayObject *)__pyx_t_4));
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1680
 *         # get the regions with scores above cutoffs
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,lvl2_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices             # <<<<<<<<<<<<<<
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 */
  __Pyx_TraceLine(1680,0,__PYX_ERR(0, 1680, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_4, __pyx_n_s_np); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_t_4, __pyx_n_s_arange); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_4 = __Pyx_PyInt_From_Py_intptr_t((__pyx_v_pos_array->dimensions[0])); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_5 = PyTuple_New(1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_GIVEREF(__pyx_t_4);
  PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_t_4);
  __pyx_t_4 = 0;
  __pyx_t_4 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  if (PyDict_SetItem(__pyx_t_4, __pyx_n_s_dtype, __pyx_n_u_int32) < 0) __PYX_ERR(0, 1680, __pyx_L1_error)
  __pyx_t_3 = __Pyx_PyObject_Call(__pyx_t_6, __pyx_t_5, __pyx_t_4); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_4 = __Pyx_PyObject_GetItem(__pyx_t_3, ((PyObject *)__pyx_v_above_cutoff)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1680, __pyx_L1_error)
  __Pyx_DECREF_SET(__pyx_v_above_cutoff_index_array, ((PyArrayObject *)__pyx_t_4));
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1681
 *         above_cutoff = np.nonzero( apply_multiple_cutoffs(score_array_s,lvl2_cutoff_s) )[0] # this is not an optimized method. It would be better to store score array in a 2-D ndarray?
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 */
  __Pyx_TraceLine(1681,0,__PYX_ERR(0, 1681, __pyx_L1_error))
  __pyx_t_4 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), ((PyObject *)__pyx_v_above_cutoff)); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1681, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  if (!(likely(((__pyx_t_4) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_4, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1681, __pyx_L1_error)
  __Pyx_DECREF_SET(__pyx_v_above_cutoff_endpos, ((PyArrayObject *)__pyx_t_4));
  __pyx_t_4 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1682
 *         above_cutoff_index_array = np.arange(pos_array.shape[0],dtype="int32")[above_cutoff] # indices
 *         above_cutoff_endpos = pos_array[above_cutoff] # end positions of regions where score is above cutoff
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff             # <<<<<<<<<<<<<<
 * 
 *         if above_cutoff.size == 0:
 */
  __Pyx_TraceLine(1682,0,__PYX_ERR(0, 1682, __pyx_L1_error))
  __pyx_t_4 = PyNumber_Subtract(((PyObject *)__pyx_v_above_cutoff), __pyx_int_1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1682, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_3 = __Pyx_PyObject_GetItem(((PyObject *)__pyx_v_pos_array), __pyx_t_4); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1682, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1682, __pyx_L1_error)
  __Pyx_DECREF_SET(__pyx_v_above_cutoff_startpos, ((PyArrayObject *)__pyx_t_3));
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1684
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *         if above_cutoff.size == 0:             # <<<<<<<<<<<<<<
 *             # nothing above cutoff
 *             return
 */
  __Pyx_TraceLine(1684,0,__PYX_ERR(0, 1684, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_above_cutoff), __pyx_n_s_size); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1684, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = __Pyx_PyInt_EqObjC(__pyx_t_3, __pyx_int_0, 0, 0); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1684, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1684, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  if (__pyx_t_7) {

    /* "MACS2/IO/CallPeakUnit.pyx":1686
 *         if above_cutoff.size == 0:
 *             # nothing above cutoff
 *             return             # <<<<<<<<<<<<<<
 * 
 *         if above_cutoff[0] == 0:
 */
    __Pyx_TraceLine(1686,0,__PYX_ERR(0, 1686, __pyx_L1_error))
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1684
 *         above_cutoff_startpos = pos_array[above_cutoff-1] # start positions of regions where score is above cutoff
 * 
 *         if above_cutoff.size == 0:             # <<<<<<<<<<<<<<
 *             # nothing above cutoff
 *             return
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1688
 *             return
 * 
 *         if above_cutoff[0] == 0:             # <<<<<<<<<<<<<<
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0
 */
  __Pyx_TraceLine(1688,0,__PYX_ERR(0, 1688, __pyx_L1_error))
  __pyx_t_4 = __Pyx_GetItemInt(((PyObject *)__pyx_v_above_cutoff), 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1688, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_3 = __Pyx_PyInt_EqObjC(__pyx_t_4, __pyx_int_0, 0, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1688, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
  __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1688, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (__pyx_t_7) {

    /* "MACS2/IO/CallPeakUnit.pyx":1690
 *         if above_cutoff[0] == 0:
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0             # <<<<<<<<<<<<<<
 * 
 *         # first bit of region above cutoff
 */
    __Pyx_TraceLine(1690,0,__PYX_ERR(0, 1690, __pyx_L1_error))
    if (unlikely(__Pyx_SetItemInt(((PyObject *)__pyx_v_above_cutoff_startpos), 0, __pyx_int_0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1) < 0)) __PYX_ERR(0, 1690, __pyx_L1_error)

    /* "MACS2/IO/CallPeakUnit.pyx":1688
 *             return
 * 
 *         if above_cutoff[0] == 0:             # <<<<<<<<<<<<<<
 *             # first element > cutoff, fix the first point as 0. otherwise it would be the last item in data[chrom]['pos']
 *             above_cutoff_startpos[0] = 0
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1693
 * 
 *         # first bit of region above cutoff
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data             # <<<<<<<<<<<<<<
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 */
  __Pyx_TraceLine(1693,0,__PYX_ERR(0, 1693, __pyx_L1_error))
  __pyx_v_acs_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_startpos->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1694
 *         # first bit of region above cutoff
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data             # <<<<<<<<<<<<<<
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 */
  __Pyx_TraceLine(1694,0,__PYX_ERR(0, 1694, __pyx_L1_error))
  __pyx_v_ace_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_endpos->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1695
 *         acs_ptr = <int32_t *>above_cutoff_startpos.data
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data             # <<<<<<<<<<<<<<
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 */
  __Pyx_TraceLine(1695,0,__PYX_ERR(0, 1695, __pyx_L1_error))
  __pyx_v_acia_ptr = ((__pyx_t_5numpy_int32_t *)__pyx_v_above_cutoff_index_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1696
 *         ace_ptr = <int32_t *>above_cutoff_endpos.data
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data             # <<<<<<<<<<<<<<
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 */
  __Pyx_TraceLine(1696,0,__PYX_ERR(0, 1696, __pyx_L1_error))
  __pyx_v_treat_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_treat_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1697
 *         acia_ptr= <int32_t *>above_cutoff_index_array.data
 *         treat_array_ptr = <float32_t *> treat_array.data
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data             # <<<<<<<<<<<<<<
 * 
 *         ts = acs_ptr[ 0 ]
 */
  __Pyx_TraceLine(1697,0,__PYX_ERR(0, 1697, __pyx_L1_error))
  __pyx_v_ctrl_array_ptr = ((__pyx_t_5numpy_float32_t *)__pyx_v_ctrl_array->data);

  /* "MACS2/IO/CallPeakUnit.pyx":1699
 *         ctrl_array_ptr = <float32_t *> ctrl_array.data
 * 
 *         ts = acs_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]
 */
  __Pyx_TraceLine(1699,0,__PYX_ERR(0, 1699, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1699, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF_SET(__pyx_v_ts, __pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1700
 * 
 *         ts = acs_ptr[ 0 ]
 *         te = ace_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]
 */
  __Pyx_TraceLine(1700,0,__PYX_ERR(0, 1700, __pyx_L1_error))
  __pyx_v_te = (__pyx_v_ace_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1701
 *         ts = acs_ptr[ 0 ]
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]             # <<<<<<<<<<<<<<
 *         tp = treat_array_ptr[ ti ]
 *         cp = ctrl_array_ptr[ ti ]
 */
  __Pyx_TraceLine(1701,0,__PYX_ERR(0, 1701, __pyx_L1_error))
  __pyx_v_ti = (__pyx_v_acia_ptr[0]);

  /* "MACS2/IO/CallPeakUnit.pyx":1702
 *         te = ace_ptr[ 0 ]
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *         cp = ctrl_array_ptr[ ti ]
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 */
  __Pyx_TraceLine(1702,0,__PYX_ERR(0, 1702, __pyx_L1_error))
  __pyx_t_3 = PyFloat_FromDouble((__pyx_v_treat_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1702, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF_SET(__pyx_v_tp, __pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1703
 *         ti = acia_ptr[ 0 ]
 *         tp = treat_array_ptr[ ti ]
 *         cp = ctrl_array_ptr[ ti ]             # <<<<<<<<<<<<<<
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 *         acs_ptr += 1 # move ptr
 */
  __Pyx_TraceLine(1703,0,__PYX_ERR(0, 1703, __pyx_L1_error))
  __pyx_t_3 = PyFloat_FromDouble((__pyx_v_ctrl_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1703, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF_SET(__pyx_v_cp, __pyx_t_3);
  __pyx_t_3 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1704
 *         tp = treat_array_ptr[ ti ]
 *         cp = ctrl_array_ptr[ ti ]
 *         peak_content.append( ( ts, te, tp, cp, ti ) )             # <<<<<<<<<<<<<<
 *         acs_ptr += 1 # move ptr
 *         ace_ptr += 1
 */
  __Pyx_TraceLine(1704,0,__PYX_ERR(0, 1704, __pyx_L1_error))
  __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1704, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __pyx_t_4 = __Pyx_PyInt_From_npy_int32(__pyx_v_ti); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1704, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_4);
  __pyx_t_5 = PyTuple_New(5); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1704, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_INCREF(__pyx_v_ts);
  __Pyx_GIVEREF(__pyx_v_ts);
  PyTuple_SET_ITEM(__pyx_t_5, 0, __pyx_v_ts);
  __Pyx_GIVEREF(__pyx_t_3);
  PyTuple_SET_ITEM(__pyx_t_5, 1, __pyx_t_3);
  __Pyx_INCREF(__pyx_v_tp);
  __Pyx_GIVEREF(__pyx_v_tp);
  PyTuple_SET_ITEM(__pyx_t_5, 2, __pyx_v_tp);
  __Pyx_INCREF(__pyx_v_cp);
  __Pyx_GIVEREF(__pyx_v_cp);
  PyTuple_SET_ITEM(__pyx_t_5, 3, __pyx_v_cp);
  __Pyx_GIVEREF(__pyx_t_4);
  PyTuple_SET_ITEM(__pyx_t_5, 4, __pyx_t_4);
  __pyx_t_3 = 0;
  __pyx_t_4 = 0;
  __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_peak_content, __pyx_t_5); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1704, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1705
 *         cp = ctrl_array_ptr[ ti ]
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 *         acs_ptr += 1 # move ptr             # <<<<<<<<<<<<<<
 *         ace_ptr += 1
 *         acia_ptr+= 1
 */
  __Pyx_TraceLine(1705,0,__PYX_ERR(0, 1705, __pyx_L1_error))
  __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1706
 *         peak_content.append( ( ts, te, tp, cp, ti ) )
 *         acs_ptr += 1 # move ptr
 *         ace_ptr += 1             # <<<<<<<<<<<<<<
 *         acia_ptr+= 1
 * 
 */
  __Pyx_TraceLine(1706,0,__PYX_ERR(0, 1706, __pyx_L1_error))
  __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1707
 *         acs_ptr += 1 # move ptr
 *         ace_ptr += 1
 *         acia_ptr+= 1             # <<<<<<<<<<<<<<
 * 
 *         lastp = te
 */
  __Pyx_TraceLine(1707,0,__PYX_ERR(0, 1707, __pyx_L1_error))
  __pyx_v_acia_ptr = (__pyx_v_acia_ptr + 1);

  /* "MACS2/IO/CallPeakUnit.pyx":1709
 *         acia_ptr+= 1
 * 
 *         lastp = te             # <<<<<<<<<<<<<<
 *         for i in range( 1, above_cutoff_startpos.size ):
 *             # for everything above cutoff
 */
  __Pyx_TraceLine(1709,0,__PYX_ERR(0, 1709, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1709, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF_SET(__pyx_v_lastp, __pyx_t_5);
  __pyx_t_5 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1710
 * 
 *         lastp = te
 *         for i in range( 1, above_cutoff_startpos.size ):             # <<<<<<<<<<<<<<
 *             # for everything above cutoff
 *             ts = acs_ptr[ 0 ] # get the start
 */
  __Pyx_TraceLine(1710,0,__PYX_ERR(0, 1710, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_above_cutoff_startpos), __pyx_n_s_size); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1710, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_11 = __Pyx_PyInt_As_long(__pyx_t_5); if (unlikely((__pyx_t_11 == (long)-1) && PyErr_Occurred())) __PYX_ERR(0, 1710, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_12 = __pyx_t_11;
  for (__pyx_t_8 = 1; __pyx_t_8 < __pyx_t_12; __pyx_t_8+=1) {
    __pyx_v_i = __pyx_t_8;

    /* "MACS2/IO/CallPeakUnit.pyx":1712
 *         for i in range( 1, above_cutoff_startpos.size ):
 *             # for everything above cutoff
 *             ts = acs_ptr[ 0 ] # get the start             # <<<<<<<<<<<<<<
 *             te = ace_ptr[ 0 ] # get the end
 *             ti = acia_ptr[ 0 ]# get the index
 */
    __Pyx_TraceLine(1712,0,__PYX_ERR(0, 1712, __pyx_L1_error))
    __pyx_t_5 = __Pyx_PyInt_From_npy_int32((__pyx_v_acs_ptr[0])); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1712, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF_SET(__pyx_v_ts, __pyx_t_5);
    __pyx_t_5 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1713
 *             # for everything above cutoff
 *             ts = acs_ptr[ 0 ] # get the start
 *             te = ace_ptr[ 0 ] # get the end             # <<<<<<<<<<<<<<
 *             ti = acia_ptr[ 0 ]# get the index
 * 
 */
    __Pyx_TraceLine(1713,0,__PYX_ERR(0, 1713, __pyx_L1_error))
    __pyx_v_te = (__pyx_v_ace_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1714
 *             ts = acs_ptr[ 0 ] # get the start
 *             te = ace_ptr[ 0 ] # get the end
 *             ti = acia_ptr[ 0 ]# get the index             # <<<<<<<<<<<<<<
 * 
 *             acs_ptr += 1 # move ptr
 */
    __Pyx_TraceLine(1714,0,__PYX_ERR(0, 1714, __pyx_L1_error))
    __pyx_v_ti = (__pyx_v_acia_ptr[0]);

    /* "MACS2/IO/CallPeakUnit.pyx":1716
 *             ti = acia_ptr[ 0 ]# get the index
 * 
 *             acs_ptr += 1 # move ptr             # <<<<<<<<<<<<<<
 *             ace_ptr += 1
 *             acia_ptr+= 1
 */
    __Pyx_TraceLine(1716,0,__PYX_ERR(0, 1716, __pyx_L1_error))
    __pyx_v_acs_ptr = (__pyx_v_acs_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1717
 * 
 *             acs_ptr += 1 # move ptr
 *             ace_ptr += 1             # <<<<<<<<<<<<<<
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ] # get the treatment pileup
 */
    __Pyx_TraceLine(1717,0,__PYX_ERR(0, 1717, __pyx_L1_error))
    __pyx_v_ace_ptr = (__pyx_v_ace_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1718
 *             acs_ptr += 1 # move ptr
 *             ace_ptr += 1
 *             acia_ptr+= 1             # <<<<<<<<<<<<<<
 *             tp = treat_array_ptr[ ti ] # get the treatment pileup
 *             cp = ctrl_array_ptr[ ti ]  # get the control pileup
 */
    __Pyx_TraceLine(1718,0,__PYX_ERR(0, 1718, __pyx_L1_error))
    __pyx_v_acia_ptr = (__pyx_v_acia_ptr + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1719
 *             ace_ptr += 1
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ] # get the treatment pileup             # <<<<<<<<<<<<<<
 *             cp = ctrl_array_ptr[ ti ]  # get the control pileup
 *             tl = ts - lastp # get the distance from the current point to last position of existing peak_content
 */
    __Pyx_TraceLine(1719,0,__PYX_ERR(0, 1719, __pyx_L1_error))
    __pyx_t_5 = PyFloat_FromDouble((__pyx_v_treat_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1719, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF_SET(__pyx_v_tp, __pyx_t_5);
    __pyx_t_5 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1720
 *             acia_ptr+= 1
 *             tp = treat_array_ptr[ ti ] # get the treatment pileup
 *             cp = ctrl_array_ptr[ ti ]  # get the control pileup             # <<<<<<<<<<<<<<
 *             tl = ts - lastp # get the distance from the current point to last position of existing peak_content
 * 
 */
    __Pyx_TraceLine(1720,0,__PYX_ERR(0, 1720, __pyx_L1_error))
    __pyx_t_5 = PyFloat_FromDouble((__pyx_v_ctrl_array_ptr[__pyx_v_ti])); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1720, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF_SET(__pyx_v_cp, __pyx_t_5);
    __pyx_t_5 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1721
 *             tp = treat_array_ptr[ ti ] # get the treatment pileup
 *             cp = ctrl_array_ptr[ ti ]  # get the control pileup
 *             tl = ts - lastp # get the distance from the current point to last position of existing peak_content             # <<<<<<<<<<<<<<
 * 
 *             if tl <= lvl2_max_gap:
 */
    __Pyx_TraceLine(1721,0,__PYX_ERR(0, 1721, __pyx_L1_error))
    __pyx_t_5 = PyNumber_Subtract(__pyx_v_ts, __pyx_v_lastp); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1721, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_XDECREF_SET(__pyx_v_tl, __pyx_t_5);
    __pyx_t_5 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1723
 *             tl = ts - lastp # get the distance from the current point to last position of existing peak_content
 * 
 *             if tl <= lvl2_max_gap:             # <<<<<<<<<<<<<<
 *                 # append
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )
 */
    __Pyx_TraceLine(1723,0,__PYX_ERR(0, 1723, __pyx_L1_error))
    __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_lvl2_max_gap); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1723, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_4 = PyObject_RichCompare(__pyx_v_tl, __pyx_t_5, Py_LE); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1723, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __pyx_t_7 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_7 < 0)) __PYX_ERR(0, 1723, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    if (__pyx_t_7) {

      /* "MACS2/IO/CallPeakUnit.pyx":1725
 *             if tl <= lvl2_max_gap:
 *                 # append
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )             # <<<<<<<<<<<<<<
 *                 lastp = te
 *             else:
 */
      __Pyx_TraceLine(1725,0,__PYX_ERR(0, 1725, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1725, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_ti); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1725, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_3 = PyTuple_New(5); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1725, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_INCREF(__pyx_v_ts);
      __Pyx_GIVEREF(__pyx_v_ts);
      PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_ts);
      __Pyx_GIVEREF(__pyx_t_4);
      PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_4);
      __Pyx_INCREF(__pyx_v_tp);
      __Pyx_GIVEREF(__pyx_v_tp);
      PyTuple_SET_ITEM(__pyx_t_3, 2, __pyx_v_tp);
      __Pyx_INCREF(__pyx_v_cp);
      __Pyx_GIVEREF(__pyx_v_cp);
      PyTuple_SET_ITEM(__pyx_t_3, 3, __pyx_v_cp);
      __Pyx_GIVEREF(__pyx_t_5);
      PyTuple_SET_ITEM(__pyx_t_3, 4, __pyx_t_5);
      __pyx_t_4 = 0;
      __pyx_t_5 = 0;
      __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_peak_content, __pyx_t_3); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1725, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1726
 *                 # append
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )
 *                 lastp = te             # <<<<<<<<<<<<<<
 *             else:
 *                 # close
 */
      __Pyx_TraceLine(1726,0,__PYX_ERR(0, 1726, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1726, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF_SET(__pyx_v_lastp, __pyx_t_3);
      __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1723
 *             tl = ts - lastp # get the distance from the current point to last position of existing peak_content
 * 
 *             if tl <= lvl2_max_gap:             # <<<<<<<<<<<<<<
 *                 # append
 *                 peak_content.append( ( ts, te, tp, cp, ti ) )
 */
      goto __pyx_L17;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1729
 *             else:
 *                 # close
 *                 self.__close_peak_for_broad_region (peak_content, lvl2peaks, min_length, chrom, lvl2_max_gap//2, score_array_s )             # <<<<<<<<<<<<<<
 * 
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]
 */
    __Pyx_TraceLine(1729,0,__PYX_ERR(0, 1729, __pyx_L1_error))
    /*else*/ {
      __pyx_t_3 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_for_broad_region(__pyx_v_self, __pyx_v_peak_content, __pyx_v_lvl2peaks, __pyx_v_min_length, __pyx_v_chrom, __Pyx_div_long(__pyx_v_lvl2_max_gap, 2), __pyx_v_score_array_s, NULL)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1729, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1731
 *                 self.__close_peak_for_broad_region (peak_content, lvl2peaks, min_length, chrom, lvl2_max_gap//2, score_array_s )
 * 
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]             # <<<<<<<<<<<<<<
 *                 lastp = te
 * 
 */
      __Pyx_TraceLine(1731,0,__PYX_ERR(0, 1731, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1731, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_ti); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1731, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_4 = PyTuple_New(5); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1731, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_INCREF(__pyx_v_ts);
      __Pyx_GIVEREF(__pyx_v_ts);
      PyTuple_SET_ITEM(__pyx_t_4, 0, __pyx_v_ts);
      __Pyx_GIVEREF(__pyx_t_3);
      PyTuple_SET_ITEM(__pyx_t_4, 1, __pyx_t_3);
      __Pyx_INCREF(__pyx_v_tp);
      __Pyx_GIVEREF(__pyx_v_tp);
      PyTuple_SET_ITEM(__pyx_t_4, 2, __pyx_v_tp);
      __Pyx_INCREF(__pyx_v_cp);
      __Pyx_GIVEREF(__pyx_v_cp);
      PyTuple_SET_ITEM(__pyx_t_4, 3, __pyx_v_cp);
      __Pyx_GIVEREF(__pyx_t_5);
      PyTuple_SET_ITEM(__pyx_t_4, 4, __pyx_t_5);
      __pyx_t_3 = 0;
      __pyx_t_5 = 0;
      __pyx_t_5 = PyList_New(1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1731, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_GIVEREF(__pyx_t_4);
      PyList_SET_ITEM(__pyx_t_5, 0, __pyx_t_4);
      __pyx_t_4 = 0;
      __Pyx_DECREF_SET(__pyx_v_peak_content, ((PyObject*)__pyx_t_5));
      __pyx_t_5 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1732
 * 
 *                 peak_content = [ ( ts, te, tp, cp, ti ), ]
 *                 lastp = te             # <<<<<<<<<<<<<<
 * 
 *         # save the last peak
 */
      __Pyx_TraceLine(1732,0,__PYX_ERR(0, 1732, __pyx_L1_error))
      __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_te); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1732, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_DECREF_SET(__pyx_v_lastp, __pyx_t_5);
      __pyx_t_5 = 0;
    }
    __pyx_L17:;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1735
 * 
 *         # save the last peak
 *         if peak_content:             # <<<<<<<<<<<<<<
 *             self.__close_peak_for_broad_region (peak_content, lvl2peaks, min_length, chrom, lvl2_max_gap//2, score_array_s )
 * 
 */
  __Pyx_TraceLine(1735,0,__PYX_ERR(0, 1735, __pyx_L1_error))
  __pyx_t_7 = (PyList_GET_SIZE(__pyx_v_peak_content) != 0);
  if (__pyx_t_7) {

    /* "MACS2/IO/CallPeakUnit.pyx":1736
 *         # save the last peak
 *         if peak_content:
 *             self.__close_peak_for_broad_region (peak_content, lvl2peaks, min_length, chrom, lvl2_max_gap//2, score_array_s )             # <<<<<<<<<<<<<<
 * 
 *         return
 */
    __Pyx_TraceLine(1736,0,__PYX_ERR(0, 1736, __pyx_L1_error))
    __pyx_t_5 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___close_peak_for_broad_region(__pyx_v_self, __pyx_v_peak_content, __pyx_v_lvl2peaks, __pyx_v_min_length, __pyx_v_chrom, __Pyx_div_long(__pyx_v_lvl2_max_gap, 2), __pyx_v_score_array_s, NULL)); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1736, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1735
 * 
 *         # save the last peak
 *         if peak_content:             # <<<<<<<<<<<<<<
 *             self.__close_peak_for_broad_region (peak_content, lvl2peaks, min_length, chrom, lvl2_max_gap//2, score_array_s )
 * 
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1738
 *             self.__close_peak_for_broad_region (peak_content, lvl2peaks, min_length, chrom, lvl2_max_gap//2, score_array_s )
 * 
 *         return             # <<<<<<<<<<<<<<
 * 
 *     cdef bool __close_peak_for_broad_region (self, list peak_content, peaks, int32_t min_length,
 */
  __Pyx_TraceLine(1738,0,__PYX_ERR(0, 1738, __pyx_L1_error))
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1564
 *         return broadpeaks
 * 
 *     cdef void  __chrom_call_broadpeak_using_certain_criteria ( self, lvl1peaks, lvl2peaks, bytes chrom, list scoring_function_s, list lvl1_cutoff_s, list lvl2_cutoff_s,             # <<<<<<<<<<<<<<
 *                                                          int32_t min_length, int32_t lvl1_max_gap, int32_t lvl2_max_gap, bool save_bedGraph):
 *         """ Call peaks for a chromosome.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_WriteUnraisable("MACS2.IO.CallPeakUnit.CallerFromAlignments.__chrom_call_broadpeak_using_certain_criteria", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_s);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_endpos);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_startpos);
  __Pyx_XDECREF((PyObject *)__pyx_v_pos_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_treat_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_ctrl_array);
  __Pyx_XDECREF((PyObject *)__pyx_v_above_cutoff_index_array);
  __Pyx_XDECREF(__pyx_v_score_array_s);
  __Pyx_XDECREF(__pyx_v_peak_content);
  __Pyx_XDECREF(__pyx_v_ts);
  __Pyx_XDECREF(__pyx_v_tp);
  __Pyx_XDECREF(__pyx_v_cp);
  __Pyx_XDECREF(__pyx_v_lastp);
  __Pyx_XDECREF(__pyx_v_tl);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "MACS2/IO/CallPeakUnit.pyx":1740
 *         return
 * 
 *     cdef bool __close_peak_for_broad_region (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                              bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the broad peak region, output peak boundaries, peak summit
 */

static PyBoolObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peak_content, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_min_length, PyObject *__pyx_v_chrom, CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_smoothlen, CYTHON_UNUSED PyObject *__pyx_v_score_array_s, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region *__pyx_optional_args) {
  __pyx_t_5numpy_int32_t __pyx_v_tstart;
  __pyx_t_5numpy_int32_t __pyx_v_tend;
  __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_float64_t __pyx_v_ttreat_p;
  __pyx_t_5numpy_float64_t __pyx_v_tctrl_p;
  PyObject *__pyx_v_tlist_pileup = 0;
  PyObject *__pyx_v_tlist_control = 0;
  PyObject *__pyx_v_tlist_length = 0;
  CYTHON_UNUSED __pyx_t_5numpy_int32_t __pyx_v_tlist_scores_p;
  PyArrayObject *__pyx_v_tarray_pileup = 0;
  PyArrayObject *__pyx_v_tarray_control = 0;
  PyArrayObject *__pyx_v_tarray_pscore = 0;
  PyArrayObject *__pyx_v_tarray_qscore = 0;
  PyArrayObject *__pyx_v_tarray_fc = 0;
  PyObject *__pyx_v_peak_length = NULL;
  PyBoolObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  Py_ssize_t __pyx_t_5;
  Py_ssize_t __pyx_t_6;
  __pyx_t_5numpy_int32_t __pyx_t_7;
  PyObject *__pyx_t_8 = NULL;
  PyObject *__pyx_t_9 = NULL;
  PyObject *__pyx_t_10 = NULL;
  PyObject *__pyx_t_11 = NULL;
  PyObject *(*__pyx_t_12)(PyObject *);
  __pyx_t_5numpy_int32_t __pyx_t_13;
  __pyx_t_5numpy_int32_t __pyx_t_14;
  __pyx_t_5numpy_float64_t __pyx_t_15;
  __pyx_t_5numpy_float64_t __pyx_t_16;
  __pyx_t_5numpy_int32_t __pyx_t_17;
  int __pyx_t_18;
  __Pyx_RefNannySetupContext("__close_peak_for_broad_region", 0);
  __Pyx_TraceCall("__close_peak_for_broad_region", __pyx_f[0], 1740, 0, __PYX_ERR(0, 1740, __pyx_L1_error));
  if (__pyx_optional_args) {
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1757
 *             np.ndarray tarray_pileup, tarray_control, tarray_pscore, tarray_qscore, tarray_fc
 * 
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]             # <<<<<<<<<<<<<<
 *         if peak_length >= min_length: # if the peak is too small, reject it
 *             tlist_pileup = []
 */
  __Pyx_TraceLine(1757,0,__PYX_ERR(0, 1757, __pyx_L1_error))
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1757, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1757, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_GetItemInt(__pyx_t_1, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1757, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  if (unlikely(__pyx_v_peak_content == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1757, __pyx_L1_error)
  }
  __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1757, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = __Pyx_GetItemInt(__pyx_t_1, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1757, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_3);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyNumber_Subtract(__pyx_t_2, __pyx_t_3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1757, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  __pyx_v_peak_length = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1758
 * 
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *         if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *             tlist_pileup = []
 *             tlist_control= []
 */
  __Pyx_TraceLine(1758,0,__PYX_ERR(0, 1758, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_min_length); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1758, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_3 = PyObject_RichCompare(__pyx_v_peak_length, __pyx_t_1, Py_GE); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1758, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1758, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1759
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *         if peak_length >= min_length: # if the peak is too small, reject it
 *             tlist_pileup = []             # <<<<<<<<<<<<<<
 *             tlist_control= []
 *             tlist_length = []
 */
    __Pyx_TraceLine(1759,0,__PYX_ERR(0, 1759, __pyx_L1_error))
    __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1759, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_v_tlist_pileup = ((PyObject*)__pyx_t_3);
    __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1760
 *         if peak_length >= min_length: # if the peak is too small, reject it
 *             tlist_pileup = []
 *             tlist_control= []             # <<<<<<<<<<<<<<
 *             tlist_length = []
 *             for i in range(len(peak_content)): # each position in broad peak
 */
    __Pyx_TraceLine(1760,0,__PYX_ERR(0, 1760, __pyx_L1_error))
    __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1760, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_v_tlist_control = ((PyObject*)__pyx_t_3);
    __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1761
 *             tlist_pileup = []
 *             tlist_control= []
 *             tlist_length = []             # <<<<<<<<<<<<<<
 *             for i in range(len(peak_content)): # each position in broad peak
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 */
    __Pyx_TraceLine(1761,0,__PYX_ERR(0, 1761, __pyx_L1_error))
    __pyx_t_3 = PyList_New(0); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1761, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_v_tlist_length = ((PyObject*)__pyx_t_3);
    __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1762
 *             tlist_control= []
 *             tlist_length = []
 *             for i in range(len(peak_content)): # each position in broad peak             # <<<<<<<<<<<<<<
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *                 #tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 */
    __Pyx_TraceLine(1762,0,__PYX_ERR(0, 1762, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1762, __pyx_L1_error)
    }
    __pyx_t_5 = PyList_GET_SIZE(__pyx_v_peak_content); if (unlikely(__pyx_t_5 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1762, __pyx_L1_error)
    __pyx_t_6 = __pyx_t_5;
    for (__pyx_t_7 = 0; __pyx_t_7 < __pyx_t_6; __pyx_t_7+=1) {
      __pyx_v_i = __pyx_t_7;

      /* "MACS2/IO/CallPeakUnit.pyx":1763
 *             tlist_length = []
 *             for i in range(len(peak_content)): # each position in broad peak
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]             # <<<<<<<<<<<<<<
 *                 #tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *                 tlist_pileup.append( ttreat_p )
 */
      __Pyx_TraceLine(1763,0,__PYX_ERR(0, 1763, __pyx_L1_error))
      if (unlikely(__pyx_v_peak_content == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1763, __pyx_L1_error)
      }
      __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1763, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      if ((likely(PyTuple_CheckExact(__pyx_t_3))) || (PyList_CheckExact(__pyx_t_3))) {
        PyObject* sequence = __pyx_t_3;
        Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
        if (unlikely(size != 5)) {
          if (size > 5) __Pyx_RaiseTooManyValuesError(5);
          else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
          __PYX_ERR(0, 1763, __pyx_L1_error)
        }
        #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
        if (likely(PyTuple_CheckExact(sequence))) {
          __pyx_t_1 = PyTuple_GET_ITEM(sequence, 0); 
          __pyx_t_2 = PyTuple_GET_ITEM(sequence, 1); 
          __pyx_t_8 = PyTuple_GET_ITEM(sequence, 2); 
          __pyx_t_9 = PyTuple_GET_ITEM(sequence, 3); 
          __pyx_t_10 = PyTuple_GET_ITEM(sequence, 4); 
        } else {
          __pyx_t_1 = PyList_GET_ITEM(sequence, 0); 
          __pyx_t_2 = PyList_GET_ITEM(sequence, 1); 
          __pyx_t_8 = PyList_GET_ITEM(sequence, 2); 
          __pyx_t_9 = PyList_GET_ITEM(sequence, 3); 
          __pyx_t_10 = PyList_GET_ITEM(sequence, 4); 
        }
        __Pyx_INCREF(__pyx_t_1);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_8);
        __Pyx_INCREF(__pyx_t_9);
        __Pyx_INCREF(__pyx_t_10);
        #else
        {
          Py_ssize_t i;
          PyObject** temps[5] = {&__pyx_t_1,&__pyx_t_2,&__pyx_t_8,&__pyx_t_9,&__pyx_t_10};
          for (i=0; i < 5; i++) {
            PyObject* item = PySequence_ITEM(sequence, i); if (unlikely(!item)) __PYX_ERR(0, 1763, __pyx_L1_error)
            __Pyx_GOTREF(item);
            *(temps[i]) = item;
          }
        }
        #endif
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      } else {
        Py_ssize_t index = -1;
        PyObject** temps[5] = {&__pyx_t_1,&__pyx_t_2,&__pyx_t_8,&__pyx_t_9,&__pyx_t_10};
        __pyx_t_11 = PyObject_GetIter(__pyx_t_3); if (unlikely(!__pyx_t_11)) __PYX_ERR(0, 1763, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_11);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __pyx_t_12 = Py_TYPE(__pyx_t_11)->tp_iternext;
        for (index=0; index < 5; index++) {
          PyObject* item = __pyx_t_12(__pyx_t_11); if (unlikely(!item)) goto __pyx_L6_unpacking_failed;
          __Pyx_GOTREF(item);
          *(temps[index]) = item;
        }
        if (__Pyx_IternextUnpackEndCheck(__pyx_t_12(__pyx_t_11), 5) < 0) __PYX_ERR(0, 1763, __pyx_L1_error)
        __pyx_t_12 = NULL;
        __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
        goto __pyx_L7_unpacking_done;
        __pyx_L6_unpacking_failed:;
        __Pyx_DECREF(__pyx_t_11); __pyx_t_11 = 0;
        __pyx_t_12 = NULL;
        if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
        __PYX_ERR(0, 1763, __pyx_L1_error)
        __pyx_L7_unpacking_done:;
      }
      __pyx_t_13 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_13 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1763, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_14 = __Pyx_PyInt_As_npy_int32(__pyx_t_2); if (unlikely((__pyx_t_14 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1763, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_15 = __pyx_PyFloat_AsDouble(__pyx_t_8); if (unlikely((__pyx_t_15 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1763, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __pyx_t_16 = __pyx_PyFloat_AsDouble(__pyx_t_9); if (unlikely((__pyx_t_16 == ((npy_float64)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1763, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
      __pyx_t_17 = __Pyx_PyInt_As_npy_int32(__pyx_t_10); if (unlikely((__pyx_t_17 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1763, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
      __pyx_v_tstart = __pyx_t_13;
      __pyx_v_tend = __pyx_t_14;
      __pyx_v_ttreat_p = __pyx_t_15;
      __pyx_v_tctrl_p = __pyx_t_16;
      __pyx_v_tlist_scores_p = __pyx_t_17;

      /* "MACS2/IO/CallPeakUnit.pyx":1765
 *                 (tstart, tend, ttreat_p, tctrl_p, tlist_scores_p) = peak_content[i]
 *                 #tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *                 tlist_pileup.append( ttreat_p )             # <<<<<<<<<<<<<<
 *                 tlist_control.append( tctrl_p )
 *                 tlist_length.append( tend - tstart )
 */
      __Pyx_TraceLine(1765,0,__PYX_ERR(0, 1765, __pyx_L1_error))
      __pyx_t_3 = PyFloat_FromDouble(__pyx_v_ttreat_p); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1765, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_18 = __Pyx_PyList_Append(__pyx_v_tlist_pileup, __pyx_t_3); if (unlikely(__pyx_t_18 == ((int)-1))) __PYX_ERR(0, 1765, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1766
 *                 #tscore = ttreat_p #self.pqtable[ get_pscore(int(ttreat_p), tctrl_p) ] # use qscore as general score to find summit
 *                 tlist_pileup.append( ttreat_p )
 *                 tlist_control.append( tctrl_p )             # <<<<<<<<<<<<<<
 *                 tlist_length.append( tend - tstart )
 * 
 */
      __Pyx_TraceLine(1766,0,__PYX_ERR(0, 1766, __pyx_L1_error))
      __pyx_t_3 = PyFloat_FromDouble(__pyx_v_tctrl_p); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1766, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_18 = __Pyx_PyList_Append(__pyx_v_tlist_control, __pyx_t_3); if (unlikely(__pyx_t_18 == ((int)-1))) __PYX_ERR(0, 1766, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1767
 *                 tlist_pileup.append( ttreat_p )
 *                 tlist_control.append( tctrl_p )
 *                 tlist_length.append( tend - tstart )             # <<<<<<<<<<<<<<
 * 
 *             tarray_pileup = np.array( tlist_pileup, dtype="float32")
 */
      __Pyx_TraceLine(1767,0,__PYX_ERR(0, 1767, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_npy_int32((__pyx_v_tend - __pyx_v_tstart)); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1767, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_18 = __Pyx_PyList_Append(__pyx_v_tlist_length, __pyx_t_3); if (unlikely(__pyx_t_18 == ((int)-1))) __PYX_ERR(0, 1767, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    }

    /* "MACS2/IO/CallPeakUnit.pyx":1769
 *                 tlist_length.append( tend - tstart )
 * 
 *             tarray_pileup = np.array( tlist_pileup, dtype="float32")             # <<<<<<<<<<<<<<
 *             tarray_control = np.array( tlist_control, dtype="float32")
 *             tarray_pscore = self.__cal_pscore( tarray_pileup, tarray_control )
 */
    __Pyx_TraceLine(1769,0,__PYX_ERR(0, 1769, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_3, __pyx_n_s_np); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1769, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_10 = __Pyx_PyObject_GetAttrStr(__pyx_t_3, __pyx_n_s_array); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1769, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_3 = PyTuple_New(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1769, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_INCREF(__pyx_v_tlist_pileup);
    __Pyx_GIVEREF(__pyx_v_tlist_pileup);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_tlist_pileup);
    __pyx_t_9 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1769, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1769, __pyx_L1_error)
    __pyx_t_8 = __Pyx_PyObject_Call(__pyx_t_10, __pyx_t_3, __pyx_t_9); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1769, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    if (!(likely(((__pyx_t_8) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_8, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1769, __pyx_L1_error)
    __pyx_v_tarray_pileup = ((PyArrayObject *)__pyx_t_8);
    __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1770
 * 
 *             tarray_pileup = np.array( tlist_pileup, dtype="float32")
 *             tarray_control = np.array( tlist_control, dtype="float32")             # <<<<<<<<<<<<<<
 *             tarray_pscore = self.__cal_pscore( tarray_pileup, tarray_control )
 *             tarray_qscore = self.__cal_qscore( tarray_pileup, tarray_control )
 */
    __Pyx_TraceLine(1770,0,__PYX_ERR(0, 1770, __pyx_L1_error))
    __Pyx_GetModuleGlobalName(__pyx_t_8, __pyx_n_s_np); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1770, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_9 = __Pyx_PyObject_GetAttrStr(__pyx_t_8, __pyx_n_s_array); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1770, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_8 = PyTuple_New(1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1770, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_INCREF(__pyx_v_tlist_control);
    __Pyx_GIVEREF(__pyx_v_tlist_control);
    PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_v_tlist_control);
    __pyx_t_3 = __Pyx_PyDict_NewPresized(1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1770, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    if (PyDict_SetItem(__pyx_t_3, __pyx_n_s_dtype, __pyx_n_u_float32) < 0) __PYX_ERR(0, 1770, __pyx_L1_error)
    __pyx_t_10 = __Pyx_PyObject_Call(__pyx_t_9, __pyx_t_8, __pyx_t_3); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1770, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    if (!(likely(((__pyx_t_10) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_10, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1770, __pyx_L1_error)
    __pyx_v_tarray_control = ((PyArrayObject *)__pyx_t_10);
    __pyx_t_10 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1771
 *             tarray_pileup = np.array( tlist_pileup, dtype="float32")
 *             tarray_control = np.array( tlist_control, dtype="float32")
 *             tarray_pscore = self.__cal_pscore( tarray_pileup, tarray_control )             # <<<<<<<<<<<<<<
 *             tarray_qscore = self.__cal_qscore( tarray_pileup, tarray_control )
 *             tarray_fc     = self.__cal_FE    ( tarray_pileup, tarray_control )
 */
    __Pyx_TraceLine(1771,0,__PYX_ERR(0, 1771, __pyx_L1_error))
    __pyx_t_10 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_pscore(__pyx_v_self, ((PyArrayObject *)__pyx_v_tarray_pileup), ((PyArrayObject *)__pyx_v_tarray_control))); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1771, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __pyx_v_tarray_pscore = ((PyArrayObject *)__pyx_t_10);
    __pyx_t_10 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1772
 *             tarray_control = np.array( tlist_control, dtype="float32")
 *             tarray_pscore = self.__cal_pscore( tarray_pileup, tarray_control )
 *             tarray_qscore = self.__cal_qscore( tarray_pileup, tarray_control )             # <<<<<<<<<<<<<<
 *             tarray_fc     = self.__cal_FE    ( tarray_pileup, tarray_control )
 * 
 */
    __Pyx_TraceLine(1772,0,__PYX_ERR(0, 1772, __pyx_L1_error))
    __pyx_t_10 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_qscore(__pyx_v_self, ((PyArrayObject *)__pyx_v_tarray_pileup), ((PyArrayObject *)__pyx_v_tarray_control))); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1772, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __pyx_v_tarray_qscore = ((PyArrayObject *)__pyx_t_10);
    __pyx_t_10 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1773
 *             tarray_pscore = self.__cal_pscore( tarray_pileup, tarray_control )
 *             tarray_qscore = self.__cal_qscore( tarray_pileup, tarray_control )
 *             tarray_fc     = self.__cal_FE    ( tarray_pileup, tarray_control )             # <<<<<<<<<<<<<<
 * 
 *             peaks.add( chrom,           # chromosome
 */
    __Pyx_TraceLine(1773,0,__PYX_ERR(0, 1773, __pyx_L1_error))
    __pyx_t_10 = ((PyObject *)((struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self->__pyx_vtab)->__pyx___cal_FE(__pyx_v_self, ((PyArrayObject *)__pyx_v_tarray_pileup), ((PyArrayObject *)__pyx_v_tarray_control))); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1773, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);
    __pyx_v_tarray_fc = ((PyArrayObject *)__pyx_t_10);
    __pyx_t_10 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1775
 *             tarray_fc     = self.__cal_FE    ( tarray_pileup, tarray_control )
 * 
 *             peaks.add( chrom,           # chromosome             # <<<<<<<<<<<<<<
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 */
    __Pyx_TraceLine(1775,0,__PYX_ERR(0, 1775, __pyx_L1_error))
    __pyx_t_10 = __Pyx_PyObject_GetAttrStr(__pyx_v_peaks, __pyx_n_s_add); if (unlikely(!__pyx_t_10)) __PYX_ERR(0, 1775, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_10);

    /* "MACS2/IO/CallPeakUnit.pyx":1776
 * 
 *             peaks.add( chrom,           # chromosome
 *                        peak_content[0][0], # start             # <<<<<<<<<<<<<<
 *                        peak_content[-1][1], # end
 *                        summit = 0,
 */
    __Pyx_TraceLine(1776,0,__PYX_ERR(0, 1776, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1776, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1776, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_8 = __Pyx_GetItemInt(__pyx_t_3, 0, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1776, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1777
 *             peaks.add( chrom,           # chromosome
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end             # <<<<<<<<<<<<<<
 *                        summit = 0,
 *                        peak_score  = mean_from_value_length( tarray_qscore, tlist_length ),
 */
    __Pyx_TraceLine(1777,0,__PYX_ERR(0, 1777, __pyx_L1_error))
    if (unlikely(__pyx_v_peak_content == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(0, 1777, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_GetItemInt_List(__pyx_v_peak_content, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1777, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __pyx_t_9 = __Pyx_GetItemInt(__pyx_t_3, 1, long, 1, __Pyx_PyInt_From_long, 0, 0, 1); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1777, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1775
 *             tarray_fc     = self.__cal_FE    ( tarray_pileup, tarray_control )
 * 
 *             peaks.add( chrom,           # chromosome             # <<<<<<<<<<<<<<
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 */
    __Pyx_TraceLine(1775,0,__PYX_ERR(0, 1775, __pyx_L1_error))
    __pyx_t_3 = PyTuple_New(3); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1775, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_INCREF(__pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_v_chrom);
    PyTuple_SET_ITEM(__pyx_t_3, 0, __pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_t_8);
    PyTuple_SET_ITEM(__pyx_t_3, 1, __pyx_t_8);
    __Pyx_GIVEREF(__pyx_t_9);
    PyTuple_SET_ITEM(__pyx_t_3, 2, __pyx_t_9);
    __pyx_t_8 = 0;
    __pyx_t_9 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1778
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 *                        summit = 0,             # <<<<<<<<<<<<<<
 *                        peak_score  = mean_from_value_length( tarray_qscore, tlist_length ),
 *                        pileup      = mean_from_value_length( tarray_pileup, tlist_length ),
 */
    __Pyx_TraceLine(1778,0,__PYX_ERR(0, 1778, __pyx_L1_error))
    __pyx_t_9 = __Pyx_PyDict_NewPresized(6); if (unlikely(!__pyx_t_9)) __PYX_ERR(0, 1778, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_9);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_summit, __pyx_int_0) < 0) __PYX_ERR(0, 1778, __pyx_L1_error)

    /* "MACS2/IO/CallPeakUnit.pyx":1779
 *                        peak_content[-1][1], # end
 *                        summit = 0,
 *                        peak_score  = mean_from_value_length( tarray_qscore, tlist_length ),             # <<<<<<<<<<<<<<
 *                        pileup      = mean_from_value_length( tarray_pileup, tlist_length ),
 *                        pscore      = mean_from_value_length( tarray_pscore, tlist_length ),
 */
    __Pyx_TraceLine(1779,0,__PYX_ERR(0, 1779, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_f_5MACS2_2IO_12CallPeakUnit_mean_from_value_length(((PyArrayObject *)__pyx_v_tarray_qscore), __pyx_v_tlist_length)); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1779, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_peak_score, __pyx_t_8) < 0) __PYX_ERR(0, 1778, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1780
 *                        summit = 0,
 *                        peak_score  = mean_from_value_length( tarray_qscore, tlist_length ),
 *                        pileup      = mean_from_value_length( tarray_pileup, tlist_length ),             # <<<<<<<<<<<<<<
 *                        pscore      = mean_from_value_length( tarray_pscore, tlist_length ),
 *                        fold_change = mean_from_value_length( tarray_fc, tlist_length ),
 */
    __Pyx_TraceLine(1780,0,__PYX_ERR(0, 1780, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_f_5MACS2_2IO_12CallPeakUnit_mean_from_value_length(((PyArrayObject *)__pyx_v_tarray_pileup), __pyx_v_tlist_length)); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1780, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_pileup, __pyx_t_8) < 0) __PYX_ERR(0, 1778, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1781
 *                        peak_score  = mean_from_value_length( tarray_qscore, tlist_length ),
 *                        pileup      = mean_from_value_length( tarray_pileup, tlist_length ),
 *                        pscore      = mean_from_value_length( tarray_pscore, tlist_length ),             # <<<<<<<<<<<<<<
 *                        fold_change = mean_from_value_length( tarray_fc, tlist_length ),
 *                        qscore      = mean_from_value_length( tarray_qscore, tlist_length ),
 */
    __Pyx_TraceLine(1781,0,__PYX_ERR(0, 1781, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_f_5MACS2_2IO_12CallPeakUnit_mean_from_value_length(((PyArrayObject *)__pyx_v_tarray_pscore), __pyx_v_tlist_length)); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1781, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_pscore, __pyx_t_8) < 0) __PYX_ERR(0, 1778, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1782
 *                        pileup      = mean_from_value_length( tarray_pileup, tlist_length ),
 *                        pscore      = mean_from_value_length( tarray_pscore, tlist_length ),
 *                        fold_change = mean_from_value_length( tarray_fc, tlist_length ),             # <<<<<<<<<<<<<<
 *                        qscore      = mean_from_value_length( tarray_qscore, tlist_length ),
 *                        )
 */
    __Pyx_TraceLine(1782,0,__PYX_ERR(0, 1782, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_f_5MACS2_2IO_12CallPeakUnit_mean_from_value_length(((PyArrayObject *)__pyx_v_tarray_fc), __pyx_v_tlist_length)); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1782, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_fold_change, __pyx_t_8) < 0) __PYX_ERR(0, 1778, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1783
 *                        pscore      = mean_from_value_length( tarray_pscore, tlist_length ),
 *                        fold_change = mean_from_value_length( tarray_fc, tlist_length ),
 *                        qscore      = mean_from_value_length( tarray_qscore, tlist_length ),             # <<<<<<<<<<<<<<
 *                        )
 *             #if chrom == "chr1" and  peak_content[0][0] == 237643 and peak_content[-1][1] == 237935:
 */
    __Pyx_TraceLine(1783,0,__PYX_ERR(0, 1783, __pyx_L1_error))
    __pyx_t_8 = PyFloat_FromDouble(__pyx_f_5MACS2_2IO_12CallPeakUnit_mean_from_value_length(((PyArrayObject *)__pyx_v_tarray_qscore), __pyx_v_tlist_length)); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1783, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_9, __pyx_n_s_qscore, __pyx_t_8) < 0) __PYX_ERR(0, 1778, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1775
 *             tarray_fc     = self.__cal_FE    ( tarray_pileup, tarray_control )
 * 
 *             peaks.add( chrom,           # chromosome             # <<<<<<<<<<<<<<
 *                        peak_content[0][0], # start
 *                        peak_content[-1][1], # end
 */
    __Pyx_TraceLine(1775,0,__PYX_ERR(0, 1775, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyObject_Call(__pyx_t_10, __pyx_t_3, __pyx_t_9); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1775, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_10); __pyx_t_10 = 0;
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __Pyx_DECREF(__pyx_t_9); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1788
 *             #    print tarray_qscore, tlist_length
 *             # start a new peak
 *             return True             # <<<<<<<<<<<<<<
 * 
 *     cdef __add_broadpeak (self, bpeaks, bytes chrom, object lvl2peak, list lvl1peakset):
 */
    __Pyx_TraceLine(1788,0,__PYX_ERR(0, 1788, __pyx_L1_error))
    __Pyx_XDECREF(((PyObject *)__pyx_r));
    __Pyx_INCREF(Py_True);
    __pyx_r = ((PyBoolObject *)Py_True);
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1758
 * 
 *         peak_length = peak_content[ -1 ][ 1 ] - peak_content[ 0 ][ 0 ]
 *         if peak_length >= min_length: # if the peak is too small, reject it             # <<<<<<<<<<<<<<
 *             tlist_pileup = []
 *             tlist_control= []
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1740
 *         return
 * 
 *     cdef bool __close_peak_for_broad_region (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                              bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the broad peak region, output peak boundaries, peak summit
 */

  /* function exit code */
  __pyx_r = ((PyBoolObject *)Py_None); __Pyx_INCREF(Py_None);
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_XDECREF(__pyx_t_9);
  __Pyx_XDECREF(__pyx_t_10);
  __Pyx_XDECREF(__pyx_t_11);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__close_peak_for_broad_region", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_tlist_pileup);
  __Pyx_XDECREF(__pyx_v_tlist_control);
  __Pyx_XDECREF(__pyx_v_tlist_length);
  __Pyx_XDECREF((PyObject *)__pyx_v_tarray_pileup);
  __Pyx_XDECREF((PyObject *)__pyx_v_tarray_control);
  __Pyx_XDECREF((PyObject *)__pyx_v_tarray_pscore);
  __Pyx_XDECREF((PyObject *)__pyx_v_tarray_qscore);
  __Pyx_XDECREF((PyObject *)__pyx_v_tarray_fc);
  __Pyx_XDECREF(__pyx_v_peak_length);
  __Pyx_XGIVEREF((PyObject *)__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1790
 *             return True
 * 
 *     cdef __add_broadpeak (self, bpeaks, bytes chrom, object lvl2peak, list lvl1peakset):             # <<<<<<<<<<<<<<
 *         """Internal function to create broad peak.
 * 
 */

static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___add_broadpeak(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_bpeaks, PyObject *__pyx_v_chrom, PyObject *__pyx_v_lvl2peak, PyObject *__pyx_v_lvl1peakset) {
  __pyx_t_5numpy_int32_t __pyx_v_blockNum;
  __pyx_t_5numpy_int32_t __pyx_v_start;
  __pyx_t_5numpy_int32_t __pyx_v_end;
  PyObject *__pyx_v_blockSizes = 0;
  PyObject *__pyx_v_blockStarts = 0;
  PyObject *__pyx_v_thickStart = 0;
  PyObject *__pyx_v_thickEnd = 0;
  PyObject *__pyx_8genexpr4__pyx_v_y = NULL;
  PyObject *__pyx_8genexpr5__pyx_v_x = NULL;
  PyObject *__pyx_8genexpr6__pyx_v_x = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __pyx_t_5numpy_int32_t __pyx_t_2;
  int __pyx_t_3;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  Py_ssize_t __pyx_t_9;
  __Pyx_RefNannySetupContext("__add_broadpeak", 0);
  __Pyx_TraceCall("__add_broadpeak", __pyx_f[0], 1790, 0, __PYX_ERR(0, 1790, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":1800
 *             bytes blockSizes, blockStarts, thickStart, thickEnd,
 * 
 *         start      = lvl2peak["start"]             # <<<<<<<<<<<<<<
 *         end        = lvl2peak["end"]
 * 
 */
  __Pyx_TraceLine(1800,0,__PYX_ERR(0, 1800, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_start); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1800, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_2 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1800, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_v_start = __pyx_t_2;

  /* "MACS2/IO/CallPeakUnit.pyx":1801
 * 
 *         start      = lvl2peak["start"]
 *         end        = lvl2peak["end"]             # <<<<<<<<<<<<<<
 * 
 *         if not lvl1peakset:
 */
  __Pyx_TraceLine(1801,0,__PYX_ERR(0, 1801, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_end); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1801, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_2 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_2 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1801, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_v_end = __pyx_t_2;

  /* "MACS2/IO/CallPeakUnit.pyx":1803
 *         end        = lvl2peak["end"]
 * 
 *         if not lvl1peakset:             # <<<<<<<<<<<<<<
 *             # will complement by adding 1bps start and end to this region
 *             # may change in the future if gappedPeak format was improved.
 */
  __Pyx_TraceLine(1803,0,__PYX_ERR(0, 1803, __pyx_L1_error))
  __pyx_t_3 = (__pyx_v_lvl1peakset != Py_None)&&(PyList_GET_SIZE(__pyx_v_lvl1peakset) != 0);
  __pyx_t_4 = ((!__pyx_t_3) != 0);
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1806
 *             # will complement by adding 1bps start and end to this region
 *             # may change in the future if gappedPeak format was improved.
 *             bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=(b"%d" % start), thickEnd=(b"%d" % end),             # <<<<<<<<<<<<<<
 *                        blockNum = 2, blockSizes = b"1,1", blockStarts = (b"0,%d" % (end-start-1)), pileup = lvl2peak["pileup"],
 *                        pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 */
    __Pyx_TraceLine(1806,0,__PYX_ERR(0, 1806, __pyx_L1_error))
    __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_bpeaks, __pyx_n_s_add); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_start); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_6 = __Pyx_PyInt_From_npy_int32(__pyx_v_end); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_7 = PyTuple_New(3); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_INCREF(__pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_v_chrom);
    PyTuple_SET_ITEM(__pyx_t_7, 0, __pyx_v_chrom);
    __Pyx_GIVEREF(__pyx_t_5);
    PyTuple_SET_ITEM(__pyx_t_7, 1, __pyx_t_5);
    __Pyx_GIVEREF(__pyx_t_6);
    PyTuple_SET_ITEM(__pyx_t_7, 2, __pyx_t_6);
    __pyx_t_5 = 0;
    __pyx_t_6 = 0;
    __pyx_t_6 = __Pyx_PyDict_NewPresized(10); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_5 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_score); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_score, __pyx_t_5) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_start); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_8 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_t_5); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_thickStart, __pyx_t_8) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_8 = __Pyx_PyInt_From_npy_int32(__pyx_v_end); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_5 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_t_8); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_thickEnd, __pyx_t_5) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_blockNum, __pyx_int_2) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_blockSizes, __pyx_kp_b_1_1) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)

    /* "MACS2/IO/CallPeakUnit.pyx":1807
 *             # may change in the future if gappedPeak format was improved.
 *             bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=(b"%d" % start), thickEnd=(b"%d" % end),
 *                        blockNum = 2, blockSizes = b"1,1", blockStarts = (b"0,%d" % (end-start-1)), pileup = lvl2peak["pileup"],             # <<<<<<<<<<<<<<
 *                        pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 *                        qscore = lvl2peak["qscore"] )
 */
    __Pyx_TraceLine(1807,0,__PYX_ERR(0, 1807, __pyx_L1_error))
    __pyx_t_5 = __Pyx_PyInt_From_long(((__pyx_v_end - __pyx_v_start) - 1)); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1807, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_8 = PyNumber_Remainder(__pyx_kp_b_0_d, __pyx_t_5); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1807, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_blockStarts, __pyx_t_8) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_8 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_pileup); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1807, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_pileup, __pyx_t_8) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1808
 *             bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=(b"%d" % start), thickEnd=(b"%d" % end),
 *                        blockNum = 2, blockSizes = b"1,1", blockStarts = (b"0,%d" % (end-start-1)), pileup = lvl2peak["pileup"],
 *                        pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],             # <<<<<<<<<<<<<<
 *                        qscore = lvl2peak["qscore"] )
 *             return bpeaks
 */
    __Pyx_TraceLine(1808,0,__PYX_ERR(0, 1808, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_pscore); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1808, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_pscore, __pyx_t_8) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __pyx_t_8 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_fc); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1808, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_fold_change, __pyx_t_8) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1809
 *                        blockNum = 2, blockSizes = b"1,1", blockStarts = (b"0,%d" % (end-start-1)), pileup = lvl2peak["pileup"],
 *                        pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 *                        qscore = lvl2peak["qscore"] )             # <<<<<<<<<<<<<<
 *             return bpeaks
 * 
 */
    __Pyx_TraceLine(1809,0,__PYX_ERR(0, 1809, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_qscore); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1809, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (PyDict_SetItem(__pyx_t_6, __pyx_n_s_qscore, __pyx_t_8) < 0) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1806
 *             # will complement by adding 1bps start and end to this region
 *             # may change in the future if gappedPeak format was improved.
 *             bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=(b"%d" % start), thickEnd=(b"%d" % end),             # <<<<<<<<<<<<<<
 *                        blockNum = 2, blockSizes = b"1,1", blockStarts = (b"0,%d" % (end-start-1)), pileup = lvl2peak["pileup"],
 *                        pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 */
    __Pyx_TraceLine(1806,0,__PYX_ERR(0, 1806, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyObject_Call(__pyx_t_1, __pyx_t_7, __pyx_t_6); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1806, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1810
 *                        pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 *                        qscore = lvl2peak["qscore"] )
 *             return bpeaks             # <<<<<<<<<<<<<<
 * 
 *         thickStart = b"%d" % (lvl1peakset[0]["start"])
 */
    __Pyx_TraceLine(1810,0,__PYX_ERR(0, 1810, __pyx_L1_error))
    __Pyx_XDECREF(__pyx_r);
    __Pyx_INCREF(__pyx_v_bpeaks);
    __pyx_r = __pyx_v_bpeaks;
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1803
 *         end        = lvl2peak["end"]
 * 
 *         if not lvl1peakset:             # <<<<<<<<<<<<<<
 *             # will complement by adding 1bps start and end to this region
 *             # may change in the future if gappedPeak format was improved.
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1812
 *             return bpeaks
 * 
 *         thickStart = b"%d" % (lvl1peakset[0]["start"])             # <<<<<<<<<<<<<<
 *         thickEnd   = b"%d" % (lvl1peakset[-1]["end"])
 *         blockNum   = len(lvl1peakset)
 */
  __Pyx_TraceLine(1812,0,__PYX_ERR(0, 1812, __pyx_L1_error))
  if (unlikely(__pyx_v_lvl1peakset == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1812, __pyx_L1_error)
  }
  __pyx_t_8 = __Pyx_GetItemInt_List(__pyx_v_lvl1peakset, 0, long, 1, __Pyx_PyInt_From_long, 1, 0, 1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1812, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_6 = __Pyx_PyObject_Dict_GetItem(__pyx_t_8, __pyx_n_u_start); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1812, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  __pyx_t_8 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_t_6); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1812, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_v_thickStart = ((PyObject*)__pyx_t_8);
  __pyx_t_8 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1813
 * 
 *         thickStart = b"%d" % (lvl1peakset[0]["start"])
 *         thickEnd   = b"%d" % (lvl1peakset[-1]["end"])             # <<<<<<<<<<<<<<
 *         blockNum   = len(lvl1peakset)
 *         blockSizes = b",".join([b"%d" % y for y in [x["length"] for x in lvl1peakset]])
 */
  __Pyx_TraceLine(1813,0,__PYX_ERR(0, 1813, __pyx_L1_error))
  if (unlikely(__pyx_v_lvl1peakset == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
    __PYX_ERR(0, 1813, __pyx_L1_error)
  }
  __pyx_t_8 = __Pyx_GetItemInt_List(__pyx_v_lvl1peakset, -1L, long, 1, __Pyx_PyInt_From_long, 1, 1, 1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1813, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_6 = __Pyx_PyObject_Dict_GetItem(__pyx_t_8, __pyx_n_u_end); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1813, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  __pyx_t_8 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_t_6); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1813, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __pyx_v_thickEnd = ((PyObject*)__pyx_t_8);
  __pyx_t_8 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1814
 *         thickStart = b"%d" % (lvl1peakset[0]["start"])
 *         thickEnd   = b"%d" % (lvl1peakset[-1]["end"])
 *         blockNum   = len(lvl1peakset)             # <<<<<<<<<<<<<<
 *         blockSizes = b",".join([b"%d" % y for y in [x["length"] for x in lvl1peakset]])
 *         blockStarts = b",".join([b"%d" % x for x in getitem_then_subtract(lvl1peakset, start)])
 */
  __Pyx_TraceLine(1814,0,__PYX_ERR(0, 1814, __pyx_L1_error))
  if (unlikely(__pyx_v_lvl1peakset == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 1814, __pyx_L1_error)
  }
  __pyx_t_9 = PyList_GET_SIZE(__pyx_v_lvl1peakset); if (unlikely(__pyx_t_9 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1814, __pyx_L1_error)
  __pyx_v_blockNum = __pyx_t_9;

  /* "MACS2/IO/CallPeakUnit.pyx":1815
 *         thickEnd   = b"%d" % (lvl1peakset[-1]["end"])
 *         blockNum   = len(lvl1peakset)
 *         blockSizes = b",".join([b"%d" % y for y in [x["length"] for x in lvl1peakset]])             # <<<<<<<<<<<<<<
 *         blockStarts = b",".join([b"%d" % x for x in getitem_then_subtract(lvl1peakset, start)])
 * 
 */
  __Pyx_TraceLine(1815,0,__PYX_ERR(0, 1815, __pyx_L1_error))
  { /* enter inner scope */
    __pyx_t_8 = PyList_New(0); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1815, __pyx_L6_error)
    __Pyx_GOTREF(__pyx_t_8);
    { /* enter inner scope */
      __pyx_t_6 = PyList_New(0); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1815, __pyx_L11_error)
      __Pyx_GOTREF(__pyx_t_6);
      if (unlikely(__pyx_v_lvl1peakset == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
        __PYX_ERR(0, 1815, __pyx_L11_error)
      }
      __pyx_t_7 = __pyx_v_lvl1peakset; __Pyx_INCREF(__pyx_t_7); __pyx_t_9 = 0;
      for (;;) {
        if (__pyx_t_9 >= PyList_GET_SIZE(__pyx_t_7)) break;
        #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
        __pyx_t_1 = PyList_GET_ITEM(__pyx_t_7, __pyx_t_9); __Pyx_INCREF(__pyx_t_1); __pyx_t_9++; if (unlikely(0 < 0)) __PYX_ERR(0, 1815, __pyx_L11_error)
        #else
        __pyx_t_1 = PySequence_ITEM(__pyx_t_7, __pyx_t_9); __pyx_t_9++; if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1815, __pyx_L11_error)
        __Pyx_GOTREF(__pyx_t_1);
        #endif
        __Pyx_XDECREF_SET(__pyx_8genexpr5__pyx_v_x, __pyx_t_1);
        __pyx_t_1 = 0;
        __pyx_t_1 = __Pyx_PyObject_Dict_GetItem(__pyx_8genexpr5__pyx_v_x, __pyx_n_u_length); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1815, __pyx_L11_error)
        __Pyx_GOTREF(__pyx_t_1);
        if (unlikely(__Pyx_ListComp_Append(__pyx_t_6, (PyObject*)__pyx_t_1))) __PYX_ERR(0, 1815, __pyx_L11_error)
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      }
      __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
      __Pyx_XDECREF(__pyx_8genexpr5__pyx_v_x); __pyx_8genexpr5__pyx_v_x = 0;
      goto __pyx_L14_exit_scope;
      __pyx_L11_error:;
      __Pyx_XDECREF(__pyx_8genexpr5__pyx_v_x); __pyx_8genexpr5__pyx_v_x = 0;
      goto __pyx_L6_error;
      __pyx_L14_exit_scope:;
    } /* exit inner scope */
    __pyx_t_7 = __pyx_t_6; __Pyx_INCREF(__pyx_t_7); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    for (;;) {
      if (__pyx_t_9 >= PyList_GET_SIZE(__pyx_t_7)) break;
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      __pyx_t_6 = PyList_GET_ITEM(__pyx_t_7, __pyx_t_9); __Pyx_INCREF(__pyx_t_6); __pyx_t_9++; if (unlikely(0 < 0)) __PYX_ERR(0, 1815, __pyx_L6_error)
      #else
      __pyx_t_6 = PySequence_ITEM(__pyx_t_7, __pyx_t_9); __pyx_t_9++; if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1815, __pyx_L6_error)
      __Pyx_GOTREF(__pyx_t_6);
      #endif
      __Pyx_XDECREF_SET(__pyx_8genexpr4__pyx_v_y, __pyx_t_6);
      __pyx_t_6 = 0;
      __pyx_t_6 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_8genexpr4__pyx_v_y); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1815, __pyx_L6_error)
      __Pyx_GOTREF(__pyx_t_6);
      if (unlikely(__Pyx_ListComp_Append(__pyx_t_8, (PyObject*)__pyx_t_6))) __PYX_ERR(0, 1815, __pyx_L6_error)
      __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    }
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_XDECREF(__pyx_8genexpr4__pyx_v_y); __pyx_8genexpr4__pyx_v_y = 0;
    goto __pyx_L15_exit_scope;
    __pyx_L6_error:;
    __Pyx_XDECREF(__pyx_8genexpr4__pyx_v_y); __pyx_8genexpr4__pyx_v_y = 0;
    goto __pyx_L1_error;
    __pyx_L15_exit_scope:;
  } /* exit inner scope */
  __pyx_t_7 = __Pyx_PyBytes_Join(__pyx_kp_b__13, __pyx_t_8); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1815, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  if (!(likely(PyBytes_CheckExact(__pyx_t_7))||((__pyx_t_7) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_7)->tp_name), 0))) __PYX_ERR(0, 1815, __pyx_L1_error)
  __pyx_v_blockSizes = ((PyObject*)__pyx_t_7);
  __pyx_t_7 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1816
 *         blockNum   = len(lvl1peakset)
 *         blockSizes = b",".join([b"%d" % y for y in [x["length"] for x in lvl1peakset]])
 *         blockStarts = b",".join([b"%d" % x for x in getitem_then_subtract(lvl1peakset, start)])             # <<<<<<<<<<<<<<
 * 
 *         # add 1bp left and/or right block if necessary
 */
  __Pyx_TraceLine(1816,0,__PYX_ERR(0, 1816, __pyx_L1_error))
  { /* enter inner scope */
    __pyx_t_7 = PyList_New(0); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1816, __pyx_L18_error)
    __Pyx_GOTREF(__pyx_t_7);
    __pyx_t_8 = __pyx_f_5MACS2_2IO_12CallPeakUnit_getitem_then_subtract(__pyx_v_lvl1peakset, __pyx_v_start); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1816, __pyx_L18_error)
    __Pyx_GOTREF(__pyx_t_8);
    if (unlikely(__pyx_t_8 == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
      __PYX_ERR(0, 1816, __pyx_L18_error)
    }
    __pyx_t_6 = __pyx_t_8; __Pyx_INCREF(__pyx_t_6); __pyx_t_9 = 0;
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    for (;;) {
      if (__pyx_t_9 >= PyList_GET_SIZE(__pyx_t_6)) break;
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      __pyx_t_8 = PyList_GET_ITEM(__pyx_t_6, __pyx_t_9); __Pyx_INCREF(__pyx_t_8); __pyx_t_9++; if (unlikely(0 < 0)) __PYX_ERR(0, 1816, __pyx_L18_error)
      #else
      __pyx_t_8 = PySequence_ITEM(__pyx_t_6, __pyx_t_9); __pyx_t_9++; if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1816, __pyx_L18_error)
      __Pyx_GOTREF(__pyx_t_8);
      #endif
      __Pyx_XDECREF_SET(__pyx_8genexpr6__pyx_v_x, __pyx_t_8);
      __pyx_t_8 = 0;
      __pyx_t_8 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_8genexpr6__pyx_v_x); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1816, __pyx_L18_error)
      __Pyx_GOTREF(__pyx_t_8);
      if (unlikely(__Pyx_ListComp_Append(__pyx_t_7, (PyObject*)__pyx_t_8))) __PYX_ERR(0, 1816, __pyx_L18_error)
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    }
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_XDECREF(__pyx_8genexpr6__pyx_v_x); __pyx_8genexpr6__pyx_v_x = 0;
    goto __pyx_L21_exit_scope;
    __pyx_L18_error:;
    __Pyx_XDECREF(__pyx_8genexpr6__pyx_v_x); __pyx_8genexpr6__pyx_v_x = 0;
    goto __pyx_L1_error;
    __pyx_L21_exit_scope:;
  } /* exit inner scope */
  __pyx_t_6 = __Pyx_PyBytes_Join(__pyx_kp_b__13, __pyx_t_7); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1816, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  if (!(likely(PyBytes_CheckExact(__pyx_t_6))||((__pyx_t_6) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_6)->tp_name), 0))) __PYX_ERR(0, 1816, __pyx_L1_error)
  __pyx_v_blockStarts = ((PyObject*)__pyx_t_6);
  __pyx_t_6 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1819
 * 
 *         # add 1bp left and/or right block if necessary
 *         if int(thickStart) != start:             # <<<<<<<<<<<<<<
 *             # add 1bp left block
 *             thickStart = b"%d" % start
 */
  __Pyx_TraceLine(1819,0,__PYX_ERR(0, 1819, __pyx_L1_error))
  __pyx_t_6 = __Pyx_PyNumber_Int(__pyx_v_thickStart); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1819, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_7 = __Pyx_PyInt_From_npy_int32(__pyx_v_start); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1819, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __pyx_t_8 = PyObject_RichCompare(__pyx_t_6, __pyx_t_7, Py_NE); __Pyx_XGOTREF(__pyx_t_8); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1819, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_8); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1819, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1821
 *         if int(thickStart) != start:
 *             # add 1bp left block
 *             thickStart = b"%d" % start             # <<<<<<<<<<<<<<
 *             blockNum += 1
 *             blockSizes = b"1,"+blockSizes
 */
    __Pyx_TraceLine(1821,0,__PYX_ERR(0, 1821, __pyx_L1_error))
    __pyx_t_8 = __Pyx_PyInt_From_npy_int32(__pyx_v_start); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1821, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_7 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_t_8); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1821, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF_SET(__pyx_v_thickStart, ((PyObject*)__pyx_t_7));
    __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1822
 *             # add 1bp left block
 *             thickStart = b"%d" % start
 *             blockNum += 1             # <<<<<<<<<<<<<<
 *             blockSizes = b"1,"+blockSizes
 *             blockStarts = b"0,"+blockStarts
 */
    __Pyx_TraceLine(1822,0,__PYX_ERR(0, 1822, __pyx_L1_error))
    __pyx_v_blockNum = (__pyx_v_blockNum + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1823
 *             thickStart = b"%d" % start
 *             blockNum += 1
 *             blockSizes = b"1,"+blockSizes             # <<<<<<<<<<<<<<
 *             blockStarts = b"0,"+blockStarts
 *         if int(thickEnd) != end:
 */
    __Pyx_TraceLine(1823,0,__PYX_ERR(0, 1823, __pyx_L1_error))
    __pyx_t_7 = PyNumber_Add(__pyx_kp_b_1, __pyx_v_blockSizes); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1823, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF_SET(__pyx_v_blockSizes, ((PyObject*)__pyx_t_7));
    __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1824
 *             blockNum += 1
 *             blockSizes = b"1,"+blockSizes
 *             blockStarts = b"0,"+blockStarts             # <<<<<<<<<<<<<<
 *         if int(thickEnd) != end:
 *             # add 1bp right block
 */
    __Pyx_TraceLine(1824,0,__PYX_ERR(0, 1824, __pyx_L1_error))
    __pyx_t_7 = PyNumber_Add(__pyx_kp_b_0, __pyx_v_blockStarts); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1824, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF_SET(__pyx_v_blockStarts, ((PyObject*)__pyx_t_7));
    __pyx_t_7 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1819
 * 
 *         # add 1bp left and/or right block if necessary
 *         if int(thickStart) != start:             # <<<<<<<<<<<<<<
 *             # add 1bp left block
 *             thickStart = b"%d" % start
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1825
 *             blockSizes = b"1,"+blockSizes
 *             blockStarts = b"0,"+blockStarts
 *         if int(thickEnd) != end:             # <<<<<<<<<<<<<<
 *             # add 1bp right block
 *             thickEnd = b"%d" % end
 */
  __Pyx_TraceLine(1825,0,__PYX_ERR(0, 1825, __pyx_L1_error))
  __pyx_t_7 = __Pyx_PyNumber_Int(__pyx_v_thickEnd); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1825, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __pyx_t_8 = __Pyx_PyInt_From_npy_int32(__pyx_v_end); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1825, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_6 = PyObject_RichCompare(__pyx_t_7, __pyx_t_8, Py_NE); __Pyx_XGOTREF(__pyx_t_6); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1825, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  __pyx_t_4 = __Pyx_PyObject_IsTrue(__pyx_t_6); if (unlikely(__pyx_t_4 < 0)) __PYX_ERR(0, 1825, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  if (__pyx_t_4) {

    /* "MACS2/IO/CallPeakUnit.pyx":1827
 *         if int(thickEnd) != end:
 *             # add 1bp right block
 *             thickEnd = b"%d" % end             # <<<<<<<<<<<<<<
 *             blockNum += 1
 *             blockSizes = blockSizes + b",1"
 */
    __Pyx_TraceLine(1827,0,__PYX_ERR(0, 1827, __pyx_L1_error))
    __pyx_t_6 = __Pyx_PyInt_From_npy_int32(__pyx_v_end); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1827, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_8 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_t_6); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1827, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __Pyx_DECREF_SET(__pyx_v_thickEnd, ((PyObject*)__pyx_t_8));
    __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1828
 *             # add 1bp right block
 *             thickEnd = b"%d" % end
 *             blockNum += 1             # <<<<<<<<<<<<<<
 *             blockSizes = blockSizes + b",1"
 *             blockStarts = blockStarts + b"," + (b"%d" % (end-start-1))
 */
    __Pyx_TraceLine(1828,0,__PYX_ERR(0, 1828, __pyx_L1_error))
    __pyx_v_blockNum = (__pyx_v_blockNum + 1);

    /* "MACS2/IO/CallPeakUnit.pyx":1829
 *             thickEnd = b"%d" % end
 *             blockNum += 1
 *             blockSizes = blockSizes + b",1"             # <<<<<<<<<<<<<<
 *             blockStarts = blockStarts + b"," + (b"%d" % (end-start-1))
 * 
 */
    __Pyx_TraceLine(1829,0,__PYX_ERR(0, 1829, __pyx_L1_error))
    __pyx_t_8 = PyNumber_Add(__pyx_v_blockSizes, __pyx_kp_b_1_2); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1829, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __Pyx_DECREF_SET(__pyx_v_blockSizes, ((PyObject*)__pyx_t_8));
    __pyx_t_8 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1830
 *             blockNum += 1
 *             blockSizes = blockSizes + b",1"
 *             blockStarts = blockStarts + b"," + (b"%d" % (end-start-1))             # <<<<<<<<<<<<<<
 * 
 *         bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=thickStart, thickEnd=thickEnd,
 */
    __Pyx_TraceLine(1830,0,__PYX_ERR(0, 1830, __pyx_L1_error))
    __pyx_t_8 = PyNumber_Add(__pyx_v_blockStarts, __pyx_kp_b__13); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1830, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_8);
    __pyx_t_6 = __Pyx_PyInt_From_long(((__pyx_v_end - __pyx_v_start) - 1)); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1830, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __pyx_t_7 = PyNumber_Remainder(__pyx_kp_b_d_2, __pyx_t_6); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1830, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_7);
    __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
    __pyx_t_6 = PyNumber_Add(__pyx_t_8, __pyx_t_7); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1830, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_6);
    __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
    __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
    __Pyx_DECREF_SET(__pyx_v_blockStarts, ((PyObject*)__pyx_t_6));
    __pyx_t_6 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1825
 *             blockSizes = b"1,"+blockSizes
 *             blockStarts = b"0,"+blockStarts
 *         if int(thickEnd) != end:             # <<<<<<<<<<<<<<
 *             # add 1bp right block
 *             thickEnd = b"%d" % end
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1832
 *             blockStarts = blockStarts + b"," + (b"%d" % (end-start-1))
 * 
 *         bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=thickStart, thickEnd=thickEnd,             # <<<<<<<<<<<<<<
 *                    blockNum = blockNum, blockSizes = blockSizes, blockStarts = blockStarts, pileup = lvl2peak["pileup"],
 *                    pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 */
  __Pyx_TraceLine(1832,0,__PYX_ERR(0, 1832, __pyx_L1_error))
  __pyx_t_6 = __Pyx_PyObject_GetAttrStr(__pyx_v_bpeaks, __pyx_n_s_add); if (unlikely(!__pyx_t_6)) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_6);
  __pyx_t_7 = __Pyx_PyInt_From_npy_int32(__pyx_v_start); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __pyx_t_8 = __Pyx_PyInt_From_npy_int32(__pyx_v_end); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_1 = PyTuple_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_v_chrom);
  __Pyx_GIVEREF(__pyx_v_chrom);
  PyTuple_SET_ITEM(__pyx_t_1, 0, __pyx_v_chrom);
  __Pyx_GIVEREF(__pyx_t_7);
  PyTuple_SET_ITEM(__pyx_t_1, 1, __pyx_t_7);
  __Pyx_GIVEREF(__pyx_t_8);
  PyTuple_SET_ITEM(__pyx_t_1, 2, __pyx_t_8);
  __pyx_t_7 = 0;
  __pyx_t_8 = 0;
  __pyx_t_8 = __Pyx_PyDict_NewPresized(10); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_8);
  __pyx_t_7 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_score); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_score, __pyx_t_7) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_thickStart, __pyx_v_thickStart) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_thickEnd, __pyx_v_thickEnd) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)

  /* "MACS2/IO/CallPeakUnit.pyx":1833
 * 
 *         bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=thickStart, thickEnd=thickEnd,
 *                    blockNum = blockNum, blockSizes = blockSizes, blockStarts = blockStarts, pileup = lvl2peak["pileup"],             # <<<<<<<<<<<<<<
 *                    pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 *                    qscore = lvl2peak["qscore"] )
 */
  __Pyx_TraceLine(1833,0,__PYX_ERR(0, 1833, __pyx_L1_error))
  __pyx_t_7 = __Pyx_PyInt_From_npy_int32(__pyx_v_blockNum); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1833, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_blockNum, __pyx_t_7) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_blockSizes, __pyx_v_blockSizes) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_blockStarts, __pyx_v_blockStarts) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  __pyx_t_7 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_pileup); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1833, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_pileup, __pyx_t_7) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1834
 *         bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=thickStart, thickEnd=thickEnd,
 *                    blockNum = blockNum, blockSizes = blockSizes, blockStarts = blockStarts, pileup = lvl2peak["pileup"],
 *                    pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],             # <<<<<<<<<<<<<<
 *                    qscore = lvl2peak["qscore"] )
 *         return bpeaks
 */
  __Pyx_TraceLine(1834,0,__PYX_ERR(0, 1834, __pyx_L1_error))
  __pyx_t_7 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_pscore); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1834, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_pscore, __pyx_t_7) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;
  __pyx_t_7 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_fc); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1834, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_fold_change, __pyx_t_7) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1835
 *                    blockNum = blockNum, blockSizes = blockSizes, blockStarts = blockStarts, pileup = lvl2peak["pileup"],
 *                    pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 *                    qscore = lvl2peak["qscore"] )             # <<<<<<<<<<<<<<
 *         return bpeaks
 * 
 */
  __Pyx_TraceLine(1835,0,__PYX_ERR(0, 1835, __pyx_L1_error))
  __pyx_t_7 = __Pyx_PyObject_Dict_GetItem(__pyx_v_lvl2peak, __pyx_n_u_qscore); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1835, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  if (PyDict_SetItem(__pyx_t_8, __pyx_n_s_qscore, __pyx_t_7) < 0) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1832
 *             blockStarts = blockStarts + b"," + (b"%d" % (end-start-1))
 * 
 *         bpeaks.add(chrom, start, end, score=lvl2peak["score"], thickStart=thickStart, thickEnd=thickEnd,             # <<<<<<<<<<<<<<
 *                    blockNum = blockNum, blockSizes = blockSizes, blockStarts = blockStarts, pileup = lvl2peak["pileup"],
 *                    pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 */
  __Pyx_TraceLine(1832,0,__PYX_ERR(0, 1832, __pyx_L1_error))
  __pyx_t_7 = __Pyx_PyObject_Call(__pyx_t_6, __pyx_t_1, __pyx_t_8); if (unlikely(!__pyx_t_7)) __PYX_ERR(0, 1832, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_7);
  __Pyx_DECREF(__pyx_t_6); __pyx_t_6 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
  __Pyx_DECREF(__pyx_t_7); __pyx_t_7 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1836
 *                    pscore = lvl2peak["pscore"], fold_change = lvl2peak["fc"],
 *                    qscore = lvl2peak["qscore"] )
 *         return bpeaks             # <<<<<<<<<<<<<<
 * 
 *     cpdef refine_peak_from_tags_distribution ( self, peaks, int32_t window_size = 100, float32_t cutoff = 5 ):
 */
  __Pyx_TraceLine(1836,0,__PYX_ERR(0, 1836, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_bpeaks);
  __pyx_r = __pyx_v_bpeaks;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1790
 *             return True
 * 
 *     cdef __add_broadpeak (self, bpeaks, bytes chrom, object lvl2peak, list lvl1peakset):             # <<<<<<<<<<<<<<
 *         """Internal function to create broad peak.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__add_broadpeak", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF(__pyx_v_blockSizes);
  __Pyx_XDECREF(__pyx_v_blockStarts);
  __Pyx_XDECREF(__pyx_v_thickStart);
  __Pyx_XDECREF(__pyx_v_thickEnd);
  __Pyx_XDECREF(__pyx_8genexpr4__pyx_v_y);
  __Pyx_XDECREF(__pyx_8genexpr5__pyx_v_x);
  __Pyx_XDECREF(__pyx_8genexpr6__pyx_v_x);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "MACS2/IO/CallPeakUnit.pyx":1838
 *         return bpeaks
 * 
 *     cpdef refine_peak_from_tags_distribution ( self, peaks, int32_t window_size = 100, float32_t cutoff = 5 ):             # <<<<<<<<<<<<<<
 *         """Extract tags in peak, then apply func on extracted tags.
 * 
 */

static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_13refine_peak_from_tags_distribution(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static PyObject *__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peaks, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution *__pyx_optional_args) {
  __pyx_t_5numpy_int32_t __pyx_v_window_size = ((__pyx_t_5numpy_int32_t)0x64);
  __pyx_t_5numpy_float32_t __pyx_v_cutoff = ((__pyx_t_5numpy_float32_t)5.0);
  __pyx_t_5numpy_int32_t __pyx_v_c;
  __pyx_t_5numpy_int32_t __pyx_v_m;
  __pyx_t_5numpy_int32_t __pyx_v_i;
  __pyx_t_5numpy_int32_t __pyx_v_j;
  __pyx_t_5numpy_int32_t __pyx_v_pos;
  __pyx_t_5numpy_int32_t __pyx_v_startpos;
  __pyx_t_5numpy_int32_t __pyx_v_endpos;
  PyArrayObject *__pyx_v_plus = 0;
  PyArrayObject *__pyx_v_minus = 0;
  PyArrayObject *__pyx_v_rt_plus = 0;
  PyArrayObject *__pyx_v_rt_minus = 0;
  PyObject *__pyx_v_chrom = 0;
  PyObject *__pyx_v_pchrnames = 0;
  PyObject *__pyx_v_chrnames = 0;
  PyObject *__pyx_v_temp = 0;
  CYTHON_UNUSED PyObject *__pyx_v_retval = 0;
  PyObject *__pyx_v_cpeaks = 0;
  PyArrayObject *__pyx_v_adjusted_summits = 0;
  PyArrayObject *__pyx_v_passflags = 0;
  PyObject *__pyx_v_ret_peaks = NULL;
  long __pyx_v_prev_i;
  long __pyx_v_prev_j;
  PyObject *__pyx_v_thispeak = NULL;
  PyObject *__pyx_v_adjusted_summit = NULL;
  PyObject *__pyx_v_passflag = NULL;
  PyObject *__pyx_v_tmppeak = NULL;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  int __pyx_t_7;
  PyObject *__pyx_t_8 = NULL;
  int __pyx_t_9;
  int __pyx_t_10;
  int __pyx_t_11;
  Py_ssize_t __pyx_t_12;
  Py_ssize_t __pyx_t_13;
  __pyx_t_5numpy_int32_t __pyx_t_14;
  PyObject *(*__pyx_t_15)(PyObject *);
  Py_ssize_t __pyx_t_16;
  Py_ssize_t __pyx_t_17;
  __pyx_t_5numpy_int32_t __pyx_t_18;
  __pyx_t_5numpy_int32_t __pyx_t_19;
  npy_intp __pyx_t_20;
  npy_intp __pyx_t_21;
  __pyx_t_5numpy_int32_t __pyx_t_22;
  Py_ssize_t __pyx_t_23;
  Py_ssize_t __pyx_t_24;
  __Pyx_RefNannySetupContext("refine_peak_from_tags_distribution", 0);
  __Pyx_TraceCall("refine_peak_from_tags_distribution", __pyx_f[0], 1838, 0, __PYX_ERR(0, 1838, __pyx_L1_error));
  if (__pyx_optional_args) {
    if (__pyx_optional_args->__pyx_n > 0) {
      __pyx_v_window_size = __pyx_optional_args->window_size;
      if (__pyx_optional_args->__pyx_n > 1) {
        __pyx_v_cutoff = __pyx_optional_args->cutoff;
      }
    }
  }
  /* Check if called by wrapper */
  if (unlikely(__pyx_skip_dispatch)) ;
  /* Check if overridden in Python */
  else if (unlikely((Py_TYPE(((PyObject *)__pyx_v_self))->tp_dictoffset != 0) || (Py_TYPE(((PyObject *)__pyx_v_self))->tp_flags & (Py_TPFLAGS_IS_ABSTRACT | Py_TPFLAGS_HEAPTYPE)))) {
    #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    static PY_UINT64_T __pyx_tp_dict_version = __PYX_DICT_VERSION_INIT, __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
    if (unlikely(!__Pyx_object_dict_version_matches(((PyObject *)__pyx_v_self), __pyx_tp_dict_version, __pyx_obj_dict_version))) {
      PY_UINT64_T __pyx_type_dict_guard = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      #endif
      __pyx_t_1 = __Pyx_PyObject_GetAttrStr(((PyObject *)__pyx_v_self), __pyx_n_s_refine_peak_from_tags_distributi); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1838, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if (!PyCFunction_Check(__pyx_t_1) || (PyCFunction_GET_FUNCTION(__pyx_t_1) != (PyCFunction)(void*)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_13refine_peak_from_tags_distribution)) {
        __Pyx_XDECREF(__pyx_r);
        __pyx_t_3 = __Pyx_PyInt_From_npy_int32(__pyx_v_window_size); if (unlikely(!__pyx_t_3)) __PYX_ERR(0, 1838, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_4 = PyFloat_FromDouble(__pyx_v_cutoff); if (unlikely(!__pyx_t_4)) __PYX_ERR(0, 1838, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __Pyx_INCREF(__pyx_t_1);
        __pyx_t_5 = __pyx_t_1; __pyx_t_6 = NULL;
        __pyx_t_7 = 0;
        if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
          __pyx_t_6 = PyMethod_GET_SELF(__pyx_t_5);
          if (likely(__pyx_t_6)) {
            PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
            __Pyx_INCREF(__pyx_t_6);
            __Pyx_INCREF(function);
            __Pyx_DECREF_SET(__pyx_t_5, function);
            __pyx_t_7 = 1;
          }
        }
        #if CYTHON_FAST_PYCALL
        if (PyFunction_Check(__pyx_t_5)) {
          PyObject *__pyx_temp[4] = {__pyx_t_6, __pyx_v_peaks, __pyx_t_3, __pyx_t_4};
          __pyx_t_2 = __Pyx_PyFunction_FastCall(__pyx_t_5, __pyx_temp+1-__pyx_t_7, 3+__pyx_t_7); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1838, __pyx_L1_error)
          __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        } else
        #endif
        #if CYTHON_FAST_PYCCALL
        if (__Pyx_PyFastCFunction_Check(__pyx_t_5)) {
          PyObject *__pyx_temp[4] = {__pyx_t_6, __pyx_v_peaks, __pyx_t_3, __pyx_t_4};
          __pyx_t_2 = __Pyx_PyCFunction_FastCall(__pyx_t_5, __pyx_temp+1-__pyx_t_7, 3+__pyx_t_7); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1838, __pyx_L1_error)
          __Pyx_XDECREF(__pyx_t_6); __pyx_t_6 = 0;
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
          __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        } else
        #endif
        {
          __pyx_t_8 = PyTuple_New(3+__pyx_t_7); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1838, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_8);
          if (__pyx_t_6) {
            __Pyx_GIVEREF(__pyx_t_6); PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_t_6); __pyx_t_6 = NULL;
          }
          __Pyx_INCREF(__pyx_v_peaks);
          __Pyx_GIVEREF(__pyx_v_peaks);
          PyTuple_SET_ITEM(__pyx_t_8, 0+__pyx_t_7, __pyx_v_peaks);
          __Pyx_GIVEREF(__pyx_t_3);
          PyTuple_SET_ITEM(__pyx_t_8, 1+__pyx_t_7, __pyx_t_3);
          __Pyx_GIVEREF(__pyx_t_4);
          PyTuple_SET_ITEM(__pyx_t_8, 2+__pyx_t_7, __pyx_t_4);
          __pyx_t_3 = 0;
          __pyx_t_4 = 0;
          __pyx_t_2 = __Pyx_PyObject_Call(__pyx_t_5, __pyx_t_8, NULL); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1838, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_2);
          __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        }
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        __pyx_r = __pyx_t_2;
        __pyx_t_2 = 0;
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        goto __pyx_L0;
      }
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
      __pyx_tp_dict_version = __Pyx_get_tp_dict_version(((PyObject *)__pyx_v_self));
      __pyx_obj_dict_version = __Pyx_get_object_dict_version(((PyObject *)__pyx_v_self));
      if (unlikely(__pyx_type_dict_guard != __pyx_tp_dict_version)) {
        __pyx_tp_dict_version = __pyx_obj_dict_version = __PYX_DICT_VERSION_INIT;
      }
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      #if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_PYTYPE_LOOKUP && CYTHON_USE_TYPE_SLOTS
    }
    #endif
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1861
 *             np.ndarray adjusted_summits, passflags
 * 
 *         if self.PE_mode:             # <<<<<<<<<<<<<<
 *             return None
 * 
 */
  __Pyx_TraceLine(1861,0,__PYX_ERR(0, 1861, __pyx_L1_error))
  __pyx_t_9 = __Pyx_PyObject_IsTrue(((PyObject *)__pyx_v_self->PE_mode)); if (unlikely(__pyx_t_9 < 0)) __PYX_ERR(0, 1861, __pyx_L1_error)
  if (__pyx_t_9) {

    /* "MACS2/IO/CallPeakUnit.pyx":1862
 * 
 *         if self.PE_mode:
 *             return None             # <<<<<<<<<<<<<<
 * 
 *         pchrnames = sorted(peaks.get_chr_names())
 */
    __Pyx_TraceLine(1862,0,__PYX_ERR(0, 1862, __pyx_L1_error))
    __Pyx_XDECREF(__pyx_r);
    __pyx_r = Py_None; __Pyx_INCREF(Py_None);
    goto __pyx_L0;

    /* "MACS2/IO/CallPeakUnit.pyx":1861
 *             np.ndarray adjusted_summits, passflags
 * 
 *         if self.PE_mode:             # <<<<<<<<<<<<<<
 *             return None
 * 
 */
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1864
 *             return None
 * 
 *         pchrnames = sorted(peaks.get_chr_names())             # <<<<<<<<<<<<<<
 *         retval = []
 * 
 */
  __Pyx_TraceLine(1864,0,__PYX_ERR(0, 1864, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_v_peaks, __pyx_n_s_get_chr_names); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1864, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_8 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_8 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_8)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_8);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_2 = (__pyx_t_8) ? __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_8) : __Pyx_PyObject_CallNoArg(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_8); __pyx_t_8 = 0;
  if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1864, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_t_5 = PySequence_List(__pyx_t_2); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1864, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_1 = ((PyObject*)__pyx_t_5);
  __pyx_t_5 = 0;
  __pyx_t_10 = PyList_Sort(__pyx_t_1); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1864, __pyx_L1_error)
  if (!(likely(PySet_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "set", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 1864, __pyx_L1_error)
  __pyx_v_pchrnames = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1865
 * 
 *         pchrnames = sorted(peaks.get_chr_names())
 *         retval = []             # <<<<<<<<<<<<<<
 * 
 *         # this object should be sorted
 */
  __Pyx_TraceLine(1865,0,__PYX_ERR(0, 1865, __pyx_L1_error))
  __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1865, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_v_retval = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1868
 * 
 *         # this object should be sorted
 *         if not self.treat.__sorted: self.treat.sort()             # <<<<<<<<<<<<<<
 *         # PeakIO object should be sorted
 *         peaks.sort()
 */
  __Pyx_TraceLine(1868,0,__PYX_ERR(0, 1868, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_sorted_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1868, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_t_9 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely(__pyx_t_9 < 0)) __PYX_ERR(0, 1868, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_11 = ((!__pyx_t_9) != 0);
  if (__pyx_t_11) {
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_sort); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1868, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_2 = NULL;
    if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_5))) {
      __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
      if (likely(__pyx_t_2)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_5, function);
      }
    }
    __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_2) : __Pyx_PyObject_CallNoArg(__pyx_t_5);
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1868, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1870
 *         if not self.treat.__sorted: self.treat.sort()
 *         # PeakIO object should be sorted
 *         peaks.sort()             # <<<<<<<<<<<<<<
 * 
 *         chrnames = self.treat.get_chr_names()
 */
  __Pyx_TraceLine(1870,0,__PYX_ERR(0, 1870, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_v_peaks, __pyx_n_s_sort); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1870, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_2 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_2) : __Pyx_PyObject_CallNoArg(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1870, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1872
 *         peaks.sort()
 * 
 *         chrnames = self.treat.get_chr_names()             # <<<<<<<<<<<<<<
 * 
 *         ret_peaks = PeakIO()
 */
  __Pyx_TraceLine(1872,0,__PYX_ERR(0, 1872, __pyx_L1_error))
  __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_get_chr_names); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1872, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_2 = NULL;
  if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_2) : __Pyx_PyObject_CallNoArg(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1872, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  if (!(likely(PySet_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "set", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 1872, __pyx_L1_error)
  __pyx_v_chrnames = ((PyObject*)__pyx_t_1);
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1874
 *         chrnames = self.treat.get_chr_names()
 * 
 *         ret_peaks = PeakIO()             # <<<<<<<<<<<<<<
 * 
 *         for c in range(len(pchrnames)):
 */
  __Pyx_TraceLine(1874,0,__PYX_ERR(0, 1874, __pyx_L1_error))
  __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_PeakIO); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1874, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_5);
  __pyx_t_2 = NULL;
  if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
    __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
    if (likely(__pyx_t_2)) {
      PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_2);
      __Pyx_INCREF(function);
      __Pyx_DECREF_SET(__pyx_t_5, function);
    }
  }
  __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_t_2) : __Pyx_PyObject_CallNoArg(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
  if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1874, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
  __pyx_v_ret_peaks = __pyx_t_1;
  __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1876
 *         ret_peaks = PeakIO()
 * 
 *         for c in range(len(pchrnames)):             # <<<<<<<<<<<<<<
 *             chrom = pchrnames[c]
 *             assert chrom in chrnames, "chromosome %s can't be found in the FWTrack object." % (chrom.decode())
 */
  __Pyx_TraceLine(1876,0,__PYX_ERR(0, 1876, __pyx_L1_error))
  if (unlikely(__pyx_v_pchrnames == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
    __PYX_ERR(0, 1876, __pyx_L1_error)
  }
  __pyx_t_12 = PySet_GET_SIZE(__pyx_v_pchrnames); if (unlikely(__pyx_t_12 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1876, __pyx_L1_error)
  __pyx_t_13 = __pyx_t_12;
  for (__pyx_t_14 = 0; __pyx_t_14 < __pyx_t_13; __pyx_t_14+=1) {
    __pyx_v_c = __pyx_t_14;

    /* "MACS2/IO/CallPeakUnit.pyx":1877
 * 
 *         for c in range(len(pchrnames)):
 *             chrom = pchrnames[c]             # <<<<<<<<<<<<<<
 *             assert chrom in chrnames, "chromosome %s can't be found in the FWTrack object." % (chrom.decode())
 *             (plus, minus) = self.treat.__locations[chrom]
 */
    __Pyx_TraceLine(1877,0,__PYX_ERR(0, 1877, __pyx_L1_error))
    __pyx_t_1 = __Pyx_GetItemInt(__pyx_v_pchrnames, __pyx_v_c, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1877, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    if (!(likely(PyBytes_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "bytes", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 1877, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_chrom, ((PyObject*)__pyx_t_1));
    __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1878
 *         for c in range(len(pchrnames)):
 *             chrom = pchrnames[c]
 *             assert chrom in chrnames, "chromosome %s can't be found in the FWTrack object." % (chrom.decode())             # <<<<<<<<<<<<<<
 *             (plus, minus) = self.treat.__locations[chrom]
 *             cpeaks = peaks.get_data_from_chrom(chrom)
 */
    __Pyx_TraceLine(1878,0,__PYX_ERR(0, 1878, __pyx_L1_error))
    #ifndef CYTHON_WITHOUT_ASSERTIONS
    if (unlikely(!Py_OptimizeFlag)) {
      if (unlikely(__pyx_v_chrnames == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
        __PYX_ERR(0, 1878, __pyx_L1_error)
      }
      __pyx_t_11 = (__Pyx_PySet_ContainsTF(__pyx_v_chrom, __pyx_v_chrnames, Py_EQ)); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1878, __pyx_L1_error)
      if (unlikely(!(__pyx_t_11 != 0))) {
        if (unlikely(__pyx_v_chrom == Py_None)) {
          PyErr_Format(PyExc_AttributeError, "'NoneType' object has no attribute '%.30s'", "decode");
          __PYX_ERR(0, 1878, __pyx_L1_error)
        }
        __pyx_t_1 = __Pyx_decode_bytes(__pyx_v_chrom, 0, PY_SSIZE_T_MAX, NULL, NULL, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1878, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_5 = PyUnicode_Format(__pyx_kp_u_chromosome_s_can_t_be_found_in_t, __pyx_t_1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1878, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_5);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        PyErr_SetObject(PyExc_AssertionError, __pyx_t_5);
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        __PYX_ERR(0, 1878, __pyx_L1_error)
      }
    }
    #endif

    /* "MACS2/IO/CallPeakUnit.pyx":1879
 *             chrom = pchrnames[c]
 *             assert chrom in chrnames, "chromosome %s can't be found in the FWTrack object." % (chrom.decode())
 *             (plus, minus) = self.treat.__locations[chrom]             # <<<<<<<<<<<<<<
 *             cpeaks = peaks.get_data_from_chrom(chrom)
 * 
 */
    __Pyx_TraceLine(1879,0,__PYX_ERR(0, 1879, __pyx_L1_error))
    __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_v_self->treat, __pyx_n_s_locations); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1879, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_5);
    __pyx_t_1 = __Pyx_PyObject_GetItem(__pyx_t_5, __pyx_v_chrom); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1879, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
    if ((likely(PyTuple_CheckExact(__pyx_t_1))) || (PyList_CheckExact(__pyx_t_1))) {
      PyObject* sequence = __pyx_t_1;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 2)) {
        if (size > 2) __Pyx_RaiseTooManyValuesError(2);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(0, 1879, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      if (likely(PyTuple_CheckExact(sequence))) {
        __pyx_t_5 = PyTuple_GET_ITEM(sequence, 0); 
        __pyx_t_2 = PyTuple_GET_ITEM(sequence, 1); 
      } else {
        __pyx_t_5 = PyList_GET_ITEM(sequence, 0); 
        __pyx_t_2 = PyList_GET_ITEM(sequence, 1); 
      }
      __Pyx_INCREF(__pyx_t_5);
      __Pyx_INCREF(__pyx_t_2);
      #else
      __pyx_t_5 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1879, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_2 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1879, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      #endif
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
    } else {
      Py_ssize_t index = -1;
      __pyx_t_8 = PyObject_GetIter(__pyx_t_1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1879, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_t_15 = Py_TYPE(__pyx_t_8)->tp_iternext;
      index = 0; __pyx_t_5 = __pyx_t_15(__pyx_t_8); if (unlikely(!__pyx_t_5)) goto __pyx_L7_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_5);
      index = 1; __pyx_t_2 = __pyx_t_15(__pyx_t_8); if (unlikely(!__pyx_t_2)) goto __pyx_L7_unpacking_failed;
      __Pyx_GOTREF(__pyx_t_2);
      if (__Pyx_IternextUnpackEndCheck(__pyx_t_15(__pyx_t_8), 2) < 0) __PYX_ERR(0, 1879, __pyx_L1_error)
      __pyx_t_15 = NULL;
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      goto __pyx_L8_unpacking_done;
      __pyx_L7_unpacking_failed:;
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __pyx_t_15 = NULL;
      if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
      __PYX_ERR(0, 1879, __pyx_L1_error)
      __pyx_L8_unpacking_done:;
    }
    if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1879, __pyx_L1_error)
    if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1879, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_plus, ((PyArrayObject *)__pyx_t_5));
    __pyx_t_5 = 0;
    __Pyx_XDECREF_SET(__pyx_v_minus, ((PyArrayObject *)__pyx_t_2));
    __pyx_t_2 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1880
 *             assert chrom in chrnames, "chromosome %s can't be found in the FWTrack object." % (chrom.decode())
 *             (plus, minus) = self.treat.__locations[chrom]
 *             cpeaks = peaks.get_data_from_chrom(chrom)             # <<<<<<<<<<<<<<
 * 
 *             prev_i = 0
 */
    __Pyx_TraceLine(1880,0,__PYX_ERR(0, 1880, __pyx_L1_error))
    __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_v_peaks, __pyx_n_s_get_data_from_chrom); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1880, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_2);
    __pyx_t_5 = NULL;
    if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_2))) {
      __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_2);
      if (likely(__pyx_t_5)) {
        PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_5);
        __Pyx_INCREF(function);
        __Pyx_DECREF_SET(__pyx_t_2, function);
      }
    }
    __pyx_t_1 = (__pyx_t_5) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_5, __pyx_v_chrom) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_v_chrom);
    __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
    if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1880, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_1);
    __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
    if (!(likely(PyList_CheckExact(__pyx_t_1))||((__pyx_t_1) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "list", Py_TYPE(__pyx_t_1)->tp_name), 0))) __PYX_ERR(0, 1880, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_cpeaks, ((PyObject*)__pyx_t_1));
    __pyx_t_1 = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1882
 *             cpeaks = peaks.get_data_from_chrom(chrom)
 * 
 *             prev_i = 0             # <<<<<<<<<<<<<<
 *             prev_j = 0
 *             for m in range(len(cpeaks)):
 */
    __Pyx_TraceLine(1882,0,__PYX_ERR(0, 1882, __pyx_L1_error))
    __pyx_v_prev_i = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1883
 * 
 *             prev_i = 0
 *             prev_j = 0             # <<<<<<<<<<<<<<
 *             for m in range(len(cpeaks)):
 *                 thispeak = cpeaks[m]
 */
    __Pyx_TraceLine(1883,0,__PYX_ERR(0, 1883, __pyx_L1_error))
    __pyx_v_prev_j = 0;

    /* "MACS2/IO/CallPeakUnit.pyx":1884
 *             prev_i = 0
 *             prev_j = 0
 *             for m in range(len(cpeaks)):             # <<<<<<<<<<<<<<
 *                 thispeak = cpeaks[m]
 *                 startpos = thispeak["start"] - window_size
 */
    __Pyx_TraceLine(1884,0,__PYX_ERR(0, 1884, __pyx_L1_error))
    if (unlikely(__pyx_v_cpeaks == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "object of type 'NoneType' has no len()");
      __PYX_ERR(0, 1884, __pyx_L1_error)
    }
    __pyx_t_16 = PyList_GET_SIZE(__pyx_v_cpeaks); if (unlikely(__pyx_t_16 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1884, __pyx_L1_error)
    __pyx_t_17 = __pyx_t_16;
    for (__pyx_t_18 = 0; __pyx_t_18 < __pyx_t_17; __pyx_t_18+=1) {
      __pyx_v_m = __pyx_t_18;

      /* "MACS2/IO/CallPeakUnit.pyx":1885
 *             prev_j = 0
 *             for m in range(len(cpeaks)):
 *                 thispeak = cpeaks[m]             # <<<<<<<<<<<<<<
 *                 startpos = thispeak["start"] - window_size
 *                 endpos   = thispeak["end"] + window_size
 */
      __Pyx_TraceLine(1885,0,__PYX_ERR(0, 1885, __pyx_L1_error))
      if (unlikely(__pyx_v_cpeaks == Py_None)) {
        PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
        __PYX_ERR(0, 1885, __pyx_L1_error)
      }
      __pyx_t_1 = __Pyx_GetItemInt_List(__pyx_v_cpeaks, __pyx_v_m, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 1, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1885, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_XDECREF_SET(__pyx_v_thispeak, __pyx_t_1);
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1886
 *             for m in range(len(cpeaks)):
 *                 thispeak = cpeaks[m]
 *                 startpos = thispeak["start"] - window_size             # <<<<<<<<<<<<<<
 *                 endpos   = thispeak["end"] + window_size
 *                 temp = []
 */
      __Pyx_TraceLine(1886,0,__PYX_ERR(0, 1886, __pyx_L1_error))
      __pyx_t_1 = __Pyx_PyObject_Dict_GetItem(__pyx_v_thispeak, __pyx_n_u_start); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1886, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __pyx_t_2 = __Pyx_PyInt_From_npy_int32(__pyx_v_window_size); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1886, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_5 = PyNumber_Subtract(__pyx_t_1, __pyx_t_2); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1886, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_19 = __Pyx_PyInt_As_npy_int32(__pyx_t_5); if (unlikely((__pyx_t_19 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1886, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_v_startpos = __pyx_t_19;

      /* "MACS2/IO/CallPeakUnit.pyx":1887
 *                 thispeak = cpeaks[m]
 *                 startpos = thispeak["start"] - window_size
 *                 endpos   = thispeak["end"] + window_size             # <<<<<<<<<<<<<<
 *                 temp = []
 *                 for i in range(prev_i,plus.shape[0]):
 */
      __Pyx_TraceLine(1887,0,__PYX_ERR(0, 1887, __pyx_L1_error))
      __pyx_t_5 = __Pyx_PyObject_Dict_GetItem(__pyx_v_thispeak, __pyx_n_u_end); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1887, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_2 = __Pyx_PyInt_From_npy_int32(__pyx_v_window_size); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1887, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_1 = PyNumber_Add(__pyx_t_5, __pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1887, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_19 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_19 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1887, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      __pyx_v_endpos = __pyx_t_19;

      /* "MACS2/IO/CallPeakUnit.pyx":1888
 *                 startpos = thispeak["start"] - window_size
 *                 endpos   = thispeak["end"] + window_size
 *                 temp = []             # <<<<<<<<<<<<<<
 *                 for i in range(prev_i,plus.shape[0]):
 *                     pos = plus[i]
 */
      __Pyx_TraceLine(1888,0,__PYX_ERR(0, 1888, __pyx_L1_error))
      __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1888, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_XDECREF_SET(__pyx_v_temp, ((PyObject*)__pyx_t_1));
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1889
 *                 endpos   = thispeak["end"] + window_size
 *                 temp = []
 *                 for i in range(prev_i,plus.shape[0]):             # <<<<<<<<<<<<<<
 *                     pos = plus[i]
 *                     if pos < startpos:
 */
      __Pyx_TraceLine(1889,0,__PYX_ERR(0, 1889, __pyx_L1_error))
      __pyx_t_20 = (__pyx_v_plus->dimensions[0]);
      __pyx_t_21 = __pyx_t_20;
      for (__pyx_t_19 = __pyx_v_prev_i; __pyx_t_19 < __pyx_t_21; __pyx_t_19+=1) {
        __pyx_v_i = __pyx_t_19;

        /* "MACS2/IO/CallPeakUnit.pyx":1890
 *                 temp = []
 *                 for i in range(prev_i,plus.shape[0]):
 *                     pos = plus[i]             # <<<<<<<<<<<<<<
 *                     if pos < startpos:
 *                         continue
 */
        __Pyx_TraceLine(1890,0,__PYX_ERR(0, 1890, __pyx_L1_error))
        __pyx_t_1 = __Pyx_GetItemInt(((PyObject *)__pyx_v_plus), __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1890, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_22 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_22 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1890, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __pyx_v_pos = __pyx_t_22;

        /* "MACS2/IO/CallPeakUnit.pyx":1891
 *                 for i in range(prev_i,plus.shape[0]):
 *                     pos = plus[i]
 *                     if pos < startpos:             # <<<<<<<<<<<<<<
 *                         continue
 *                     elif pos > endpos:
 */
        __Pyx_TraceLine(1891,0,__PYX_ERR(0, 1891, __pyx_L1_error))
        __pyx_t_11 = ((__pyx_v_pos < __pyx_v_startpos) != 0);
        if (__pyx_t_11) {

          /* "MACS2/IO/CallPeakUnit.pyx":1892
 *                     pos = plus[i]
 *                     if pos < startpos:
 *                         continue             # <<<<<<<<<<<<<<
 *                     elif pos > endpos:
 *                         prev_i = i
 */
          __Pyx_TraceLine(1892,0,__PYX_ERR(0, 1892, __pyx_L1_error))
          goto __pyx_L11_continue;

          /* "MACS2/IO/CallPeakUnit.pyx":1891
 *                 for i in range(prev_i,plus.shape[0]):
 *                     pos = plus[i]
 *                     if pos < startpos:             # <<<<<<<<<<<<<<
 *                         continue
 *                     elif pos > endpos:
 */
        }

        /* "MACS2/IO/CallPeakUnit.pyx":1893
 *                     if pos < startpos:
 *                         continue
 *                     elif pos > endpos:             # <<<<<<<<<<<<<<
 *                         prev_i = i
 *                         break
 */
        __Pyx_TraceLine(1893,0,__PYX_ERR(0, 1893, __pyx_L1_error))
        __pyx_t_11 = ((__pyx_v_pos > __pyx_v_endpos) != 0);
        if (__pyx_t_11) {

          /* "MACS2/IO/CallPeakUnit.pyx":1894
 *                         continue
 *                     elif pos > endpos:
 *                         prev_i = i             # <<<<<<<<<<<<<<
 *                         break
 *                     else:
 */
          __Pyx_TraceLine(1894,0,__PYX_ERR(0, 1894, __pyx_L1_error))
          __pyx_v_prev_i = __pyx_v_i;

          /* "MACS2/IO/CallPeakUnit.pyx":1895
 *                     elif pos > endpos:
 *                         prev_i = i
 *                         break             # <<<<<<<<<<<<<<
 *                     else:
 *                         temp.append(pos)
 */
          __Pyx_TraceLine(1895,0,__PYX_ERR(0, 1895, __pyx_L1_error))
          goto __pyx_L12_break;

          /* "MACS2/IO/CallPeakUnit.pyx":1893
 *                     if pos < startpos:
 *                         continue
 *                     elif pos > endpos:             # <<<<<<<<<<<<<<
 *                         prev_i = i
 *                         break
 */
        }

        /* "MACS2/IO/CallPeakUnit.pyx":1897
 *                         break
 *                     else:
 *                         temp.append(pos)             # <<<<<<<<<<<<<<
 *                 rt_plus = np.array(temp)
 * 
 */
        __Pyx_TraceLine(1897,0,__PYX_ERR(0, 1897, __pyx_L1_error))
        /*else*/ {
          __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_pos); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1897, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_temp, __pyx_t_1); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1897, __pyx_L1_error)
          __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        }
        __pyx_L11_continue:;
      }
      __pyx_L12_break:;

      /* "MACS2/IO/CallPeakUnit.pyx":1898
 *                     else:
 *                         temp.append(pos)
 *                 rt_plus = np.array(temp)             # <<<<<<<<<<<<<<
 * 
 *                 temp = []
 */
      __Pyx_TraceLine(1898,0,__PYX_ERR(0, 1898, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_2, __pyx_n_s_np); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1898, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_t_2, __pyx_n_s_array); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1898, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      __pyx_t_2 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
        __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
        if (likely(__pyx_t_2)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
          __Pyx_INCREF(__pyx_t_2);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_5, function);
        }
      }
      __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_2, __pyx_v_temp) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_v_temp);
      __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1898, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1898, __pyx_L1_error)
      __Pyx_XDECREF_SET(__pyx_v_rt_plus, ((PyArrayObject *)__pyx_t_1));
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1900
 *                 rt_plus = np.array(temp)
 * 
 *                 temp = []             # <<<<<<<<<<<<<<
 *                 for j in range(prev_j,minus.shape[0]):
 *                     pos = minus[j]
 */
      __Pyx_TraceLine(1900,0,__PYX_ERR(0, 1900, __pyx_L1_error))
      __pyx_t_1 = PyList_New(0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1900, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF_SET(__pyx_v_temp, ((PyObject*)__pyx_t_1));
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1901
 * 
 *                 temp = []
 *                 for j in range(prev_j,minus.shape[0]):             # <<<<<<<<<<<<<<
 *                     pos = minus[j]
 *                     if pos < startpos:
 */
      __Pyx_TraceLine(1901,0,__PYX_ERR(0, 1901, __pyx_L1_error))
      __pyx_t_20 = (__pyx_v_minus->dimensions[0]);
      __pyx_t_21 = __pyx_t_20;
      for (__pyx_t_19 = __pyx_v_prev_j; __pyx_t_19 < __pyx_t_21; __pyx_t_19+=1) {
        __pyx_v_j = __pyx_t_19;

        /* "MACS2/IO/CallPeakUnit.pyx":1902
 *                 temp = []
 *                 for j in range(prev_j,minus.shape[0]):
 *                     pos = minus[j]             # <<<<<<<<<<<<<<
 *                     if pos < startpos:
 *                         continue
 */
        __Pyx_TraceLine(1902,0,__PYX_ERR(0, 1902, __pyx_L1_error))
        __pyx_t_1 = __Pyx_GetItemInt(((PyObject *)__pyx_v_minus), __pyx_v_j, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1902, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_22 = __Pyx_PyInt_As_npy_int32(__pyx_t_1); if (unlikely((__pyx_t_22 == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1902, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __pyx_v_pos = __pyx_t_22;

        /* "MACS2/IO/CallPeakUnit.pyx":1903
 *                 for j in range(prev_j,minus.shape[0]):
 *                     pos = minus[j]
 *                     if pos < startpos:             # <<<<<<<<<<<<<<
 *                         continue
 *                     elif pos > endpos:
 */
        __Pyx_TraceLine(1903,0,__PYX_ERR(0, 1903, __pyx_L1_error))
        __pyx_t_11 = ((__pyx_v_pos < __pyx_v_startpos) != 0);
        if (__pyx_t_11) {

          /* "MACS2/IO/CallPeakUnit.pyx":1904
 *                     pos = minus[j]
 *                     if pos < startpos:
 *                         continue             # <<<<<<<<<<<<<<
 *                     elif pos > endpos:
 *                         prev_j = j
 */
          __Pyx_TraceLine(1904,0,__PYX_ERR(0, 1904, __pyx_L1_error))
          goto __pyx_L14_continue;

          /* "MACS2/IO/CallPeakUnit.pyx":1903
 *                 for j in range(prev_j,minus.shape[0]):
 *                     pos = minus[j]
 *                     if pos < startpos:             # <<<<<<<<<<<<<<
 *                         continue
 *                     elif pos > endpos:
 */
        }

        /* "MACS2/IO/CallPeakUnit.pyx":1905
 *                     if pos < startpos:
 *                         continue
 *                     elif pos > endpos:             # <<<<<<<<<<<<<<
 *                         prev_j = j
 *                         break
 */
        __Pyx_TraceLine(1905,0,__PYX_ERR(0, 1905, __pyx_L1_error))
        __pyx_t_11 = ((__pyx_v_pos > __pyx_v_endpos) != 0);
        if (__pyx_t_11) {

          /* "MACS2/IO/CallPeakUnit.pyx":1906
 *                         continue
 *                     elif pos > endpos:
 *                         prev_j = j             # <<<<<<<<<<<<<<
 *                         break
 *                     else:
 */
          __Pyx_TraceLine(1906,0,__PYX_ERR(0, 1906, __pyx_L1_error))
          __pyx_v_prev_j = __pyx_v_j;

          /* "MACS2/IO/CallPeakUnit.pyx":1907
 *                     elif pos > endpos:
 *                         prev_j = j
 *                         break             # <<<<<<<<<<<<<<
 *                     else:
 *                         temp.append(pos)
 */
          __Pyx_TraceLine(1907,0,__PYX_ERR(0, 1907, __pyx_L1_error))
          goto __pyx_L15_break;

          /* "MACS2/IO/CallPeakUnit.pyx":1905
 *                     if pos < startpos:
 *                         continue
 *                     elif pos > endpos:             # <<<<<<<<<<<<<<
 *                         prev_j = j
 *                         break
 */
        }

        /* "MACS2/IO/CallPeakUnit.pyx":1909
 *                         break
 *                     else:
 *                         temp.append(pos)             # <<<<<<<<<<<<<<
 *                 rt_minus = np.array(temp)
 * 
 */
        __Pyx_TraceLine(1909,0,__PYX_ERR(0, 1909, __pyx_L1_error))
        /*else*/ {
          __pyx_t_1 = __Pyx_PyInt_From_npy_int32(__pyx_v_pos); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1909, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __pyx_t_10 = __Pyx_PyList_Append(__pyx_v_temp, __pyx_t_1); if (unlikely(__pyx_t_10 == ((int)-1))) __PYX_ERR(0, 1909, __pyx_L1_error)
          __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        }
        __pyx_L14_continue:;
      }
      __pyx_L15_break:;

      /* "MACS2/IO/CallPeakUnit.pyx":1910
 *                     else:
 *                         temp.append(pos)
 *                 rt_minus = np.array(temp)             # <<<<<<<<<<<<<<
 * 
 *                 (adjusted_summits, passflags) = wtd_find_summit(chrom, rt_plus, rt_minus, startpos, endpos, window_size, cutoff)
 */
      __Pyx_TraceLine(1910,0,__PYX_ERR(0, 1910, __pyx_L1_error))
      __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_np); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1910, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_5);
      __pyx_t_2 = __Pyx_PyObject_GetAttrStr(__pyx_t_5, __pyx_n_s_array); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1910, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_2);
      __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
      __pyx_t_5 = NULL;
      if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_2))) {
        __pyx_t_5 = PyMethod_GET_SELF(__pyx_t_2);
        if (likely(__pyx_t_5)) {
          PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_2);
          __Pyx_INCREF(__pyx_t_5);
          __Pyx_INCREF(function);
          __Pyx_DECREF_SET(__pyx_t_2, function);
        }
      }
      __pyx_t_1 = (__pyx_t_5) ? __Pyx_PyObject_Call2Args(__pyx_t_2, __pyx_t_5, __pyx_v_temp) : __Pyx_PyObject_CallOneArg(__pyx_t_2, __pyx_v_temp);
      __Pyx_XDECREF(__pyx_t_5); __pyx_t_5 = 0;
      if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1910, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
      if (!(likely(((__pyx_t_1) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_1, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1910, __pyx_L1_error)
      __Pyx_XDECREF_SET(__pyx_v_rt_minus, ((PyArrayObject *)__pyx_t_1));
      __pyx_t_1 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1912
 *                 rt_minus = np.array(temp)
 * 
 *                 (adjusted_summits, passflags) = wtd_find_summit(chrom, rt_plus, rt_minus, startpos, endpos, window_size, cutoff)             # <<<<<<<<<<<<<<
 *                 # those local maxima above cutoff will be defined as good summits
 *                 for i in range(len(adjusted_summits)):
 */
      __Pyx_TraceLine(1912,0,__PYX_ERR(0, 1912, __pyx_L1_error))
      __pyx_t_1 = __pyx_f_5MACS2_2IO_12CallPeakUnit_wtd_find_summit(__pyx_v_chrom, __pyx_v_rt_plus, __pyx_v_rt_minus, __pyx_v_startpos, __pyx_v_endpos, __pyx_v_window_size, __pyx_v_cutoff); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1912, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_1);
      if ((likely(PyTuple_CheckExact(__pyx_t_1))) || (PyList_CheckExact(__pyx_t_1))) {
        PyObject* sequence = __pyx_t_1;
        Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
        if (unlikely(size != 2)) {
          if (size > 2) __Pyx_RaiseTooManyValuesError(2);
          else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
          __PYX_ERR(0, 1912, __pyx_L1_error)
        }
        #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
        if (likely(PyTuple_CheckExact(sequence))) {
          __pyx_t_2 = PyTuple_GET_ITEM(sequence, 0); 
          __pyx_t_5 = PyTuple_GET_ITEM(sequence, 1); 
        } else {
          __pyx_t_2 = PyList_GET_ITEM(sequence, 0); 
          __pyx_t_5 = PyList_GET_ITEM(sequence, 1); 
        }
        __Pyx_INCREF(__pyx_t_2);
        __Pyx_INCREF(__pyx_t_5);
        #else
        __pyx_t_2 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1912, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_2);
        __pyx_t_5 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1912, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_5);
        #endif
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
      } else {
        Py_ssize_t index = -1;
        __pyx_t_8 = PyObject_GetIter(__pyx_t_1); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1912, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_8);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __pyx_t_15 = Py_TYPE(__pyx_t_8)->tp_iternext;
        index = 0; __pyx_t_2 = __pyx_t_15(__pyx_t_8); if (unlikely(!__pyx_t_2)) goto __pyx_L17_unpacking_failed;
        __Pyx_GOTREF(__pyx_t_2);
        index = 1; __pyx_t_5 = __pyx_t_15(__pyx_t_8); if (unlikely(!__pyx_t_5)) goto __pyx_L17_unpacking_failed;
        __Pyx_GOTREF(__pyx_t_5);
        if (__Pyx_IternextUnpackEndCheck(__pyx_t_15(__pyx_t_8), 2) < 0) __PYX_ERR(0, 1912, __pyx_L1_error)
        __pyx_t_15 = NULL;
        __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        goto __pyx_L18_unpacking_done;
        __pyx_L17_unpacking_failed:;
        __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        __pyx_t_15 = NULL;
        if (__Pyx_IterFinish() == 0) __Pyx_RaiseNeedMoreValuesError(index);
        __PYX_ERR(0, 1912, __pyx_L1_error)
        __pyx_L18_unpacking_done:;
      }
      if (!(likely(((__pyx_t_2) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_2, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1912, __pyx_L1_error)
      if (!(likely(((__pyx_t_5) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_5, __pyx_ptype_5numpy_ndarray))))) __PYX_ERR(0, 1912, __pyx_L1_error)
      __Pyx_XDECREF_SET(__pyx_v_adjusted_summits, ((PyArrayObject *)__pyx_t_2));
      __pyx_t_2 = 0;
      __Pyx_XDECREF_SET(__pyx_v_passflags, ((PyArrayObject *)__pyx_t_5));
      __pyx_t_5 = 0;

      /* "MACS2/IO/CallPeakUnit.pyx":1914
 *                 (adjusted_summits, passflags) = wtd_find_summit(chrom, rt_plus, rt_minus, startpos, endpos, window_size, cutoff)
 *                 # those local maxima above cutoff will be defined as good summits
 *                 for i in range(len(adjusted_summits)):             # <<<<<<<<<<<<<<
 *                     adjusted_summit = adjusted_summits[i]
 *                     passflag = passflags[i]
 */
      __Pyx_TraceLine(1914,0,__PYX_ERR(0, 1914, __pyx_L1_error))
      __pyx_t_23 = PyObject_Length(((PyObject *)__pyx_v_adjusted_summits)); if (unlikely(__pyx_t_23 == ((Py_ssize_t)-1))) __PYX_ERR(0, 1914, __pyx_L1_error)
      __pyx_t_24 = __pyx_t_23;
      for (__pyx_t_19 = 0; __pyx_t_19 < __pyx_t_24; __pyx_t_19+=1) {
        __pyx_v_i = __pyx_t_19;

        /* "MACS2/IO/CallPeakUnit.pyx":1915
 *                 # those local maxima above cutoff will be defined as good summits
 *                 for i in range(len(adjusted_summits)):
 *                     adjusted_summit = adjusted_summits[i]             # <<<<<<<<<<<<<<
 *                     passflag = passflags[i]
 *                     if passflag:
 */
        __Pyx_TraceLine(1915,0,__PYX_ERR(0, 1915, __pyx_L1_error))
        __pyx_t_1 = __Pyx_GetItemInt(((PyObject *)__pyx_v_adjusted_summits), __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1915, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_XDECREF_SET(__pyx_v_adjusted_summit, __pyx_t_1);
        __pyx_t_1 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1916
 *                 for i in range(len(adjusted_summits)):
 *                     adjusted_summit = adjusted_summits[i]
 *                     passflag = passflags[i]             # <<<<<<<<<<<<<<
 *                     if passflag:
 *                         tmppeak = copy(thispeak)
 */
        __Pyx_TraceLine(1916,0,__PYX_ERR(0, 1916, __pyx_L1_error))
        __pyx_t_1 = __Pyx_GetItemInt(((PyObject *)__pyx_v_passflags), __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1916, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __Pyx_XDECREF_SET(__pyx_v_passflag, __pyx_t_1);
        __pyx_t_1 = 0;

        /* "MACS2/IO/CallPeakUnit.pyx":1917
 *                     adjusted_summit = adjusted_summits[i]
 *                     passflag = passflags[i]
 *                     if passflag:             # <<<<<<<<<<<<<<
 *                         tmppeak = copy(thispeak)
 *                         tmppeak["summit"] = adjusted_summit
 */
        __Pyx_TraceLine(1917,0,__PYX_ERR(0, 1917, __pyx_L1_error))
        __pyx_t_11 = __Pyx_PyObject_IsTrue(__pyx_v_passflag); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1917, __pyx_L1_error)
        if (__pyx_t_11) {

          /* "MACS2/IO/CallPeakUnit.pyx":1918
 *                     passflag = passflags[i]
 *                     if passflag:
 *                         tmppeak = copy(thispeak)             # <<<<<<<<<<<<<<
 *                         tmppeak["summit"] = adjusted_summit
 *                         ret_peaks.add_PeakContent(chrom, tmppeak)
 */
          __Pyx_TraceLine(1918,0,__PYX_ERR(0, 1918, __pyx_L1_error))
          __Pyx_GetModuleGlobalName(__pyx_t_5, __pyx_n_s_copy); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1918, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_5);
          __pyx_t_2 = NULL;
          if (CYTHON_UNPACK_METHODS && unlikely(PyMethod_Check(__pyx_t_5))) {
            __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
            if (likely(__pyx_t_2)) {
              PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
              __Pyx_INCREF(__pyx_t_2);
              __Pyx_INCREF(function);
              __Pyx_DECREF_SET(__pyx_t_5, function);
            }
          }
          __pyx_t_1 = (__pyx_t_2) ? __Pyx_PyObject_Call2Args(__pyx_t_5, __pyx_t_2, __pyx_v_thispeak) : __Pyx_PyObject_CallOneArg(__pyx_t_5, __pyx_v_thispeak);
          __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
          if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1918, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_1);
          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
          __Pyx_XDECREF_SET(__pyx_v_tmppeak, __pyx_t_1);
          __pyx_t_1 = 0;

          /* "MACS2/IO/CallPeakUnit.pyx":1919
 *                     if passflag:
 *                         tmppeak = copy(thispeak)
 *                         tmppeak["summit"] = adjusted_summit             # <<<<<<<<<<<<<<
 *                         ret_peaks.add_PeakContent(chrom, tmppeak)
 * 
 */
          __Pyx_TraceLine(1919,0,__PYX_ERR(0, 1919, __pyx_L1_error))
          if (unlikely(PyObject_SetItem(__pyx_v_tmppeak, __pyx_n_u_summit, __pyx_v_adjusted_summit) < 0)) __PYX_ERR(0, 1919, __pyx_L1_error)

          /* "MACS2/IO/CallPeakUnit.pyx":1920
 *                         tmppeak = copy(thispeak)
 *                         tmppeak["summit"] = adjusted_summit
 *                         ret_peaks.add_PeakContent(chrom, tmppeak)             # <<<<<<<<<<<<<<
 * 
 *                 # rewind window_size
 */
          __Pyx_TraceLine(1920,0,__PYX_ERR(0, 1920, __pyx_L1_error))
          __pyx_t_5 = __Pyx_PyObject_GetAttrStr(__pyx_v_ret_peaks, __pyx_n_s_add_PeakContent); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1920, __pyx_L1_error)
          __Pyx_GOTREF(__pyx_t_5);
          __pyx_t_2 = NULL;
          __pyx_t_7 = 0;
          if (CYTHON_UNPACK_METHODS && likely(PyMethod_Check(__pyx_t_5))) {
            __pyx_t_2 = PyMethod_GET_SELF(__pyx_t_5);
            if (likely(__pyx_t_2)) {
              PyObject* function = PyMethod_GET_FUNCTION(__pyx_t_5);
              __Pyx_INCREF(__pyx_t_2);
              __Pyx_INCREF(function);
              __Pyx_DECREF_SET(__pyx_t_5, function);
              __pyx_t_7 = 1;
            }
          }
          #if CYTHON_FAST_PYCALL
          if (PyFunction_Check(__pyx_t_5)) {
            PyObject *__pyx_temp[3] = {__pyx_t_2, __pyx_v_chrom, __pyx_v_tmppeak};
            __pyx_t_1 = __Pyx_PyFunction_FastCall(__pyx_t_5, __pyx_temp+1-__pyx_t_7, 2+__pyx_t_7); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1920, __pyx_L1_error)
            __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
            __Pyx_GOTREF(__pyx_t_1);
          } else
          #endif
          #if CYTHON_FAST_PYCCALL
          if (__Pyx_PyFastCFunction_Check(__pyx_t_5)) {
            PyObject *__pyx_temp[3] = {__pyx_t_2, __pyx_v_chrom, __pyx_v_tmppeak};
            __pyx_t_1 = __Pyx_PyCFunction_FastCall(__pyx_t_5, __pyx_temp+1-__pyx_t_7, 2+__pyx_t_7); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1920, __pyx_L1_error)
            __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
            __Pyx_GOTREF(__pyx_t_1);
          } else
          #endif
          {
            __pyx_t_8 = PyTuple_New(2+__pyx_t_7); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1920, __pyx_L1_error)
            __Pyx_GOTREF(__pyx_t_8);
            if (__pyx_t_2) {
              __Pyx_GIVEREF(__pyx_t_2); PyTuple_SET_ITEM(__pyx_t_8, 0, __pyx_t_2); __pyx_t_2 = NULL;
            }
            __Pyx_INCREF(__pyx_v_chrom);
            __Pyx_GIVEREF(__pyx_v_chrom);
            PyTuple_SET_ITEM(__pyx_t_8, 0+__pyx_t_7, __pyx_v_chrom);
            __Pyx_INCREF(__pyx_v_tmppeak);
            __Pyx_GIVEREF(__pyx_v_tmppeak);
            PyTuple_SET_ITEM(__pyx_t_8, 1+__pyx_t_7, __pyx_v_tmppeak);
            __pyx_t_1 = __Pyx_PyObject_Call(__pyx_t_5, __pyx_t_8, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1920, __pyx_L1_error)
            __Pyx_GOTREF(__pyx_t_1);
            __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
          }
          __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
          __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

          /* "MACS2/IO/CallPeakUnit.pyx":1917
 *                     adjusted_summit = adjusted_summits[i]
 *                     passflag = passflags[i]
 *                     if passflag:             # <<<<<<<<<<<<<<
 *                         tmppeak = copy(thispeak)
 *                         tmppeak["summit"] = adjusted_summit
 */
        }
      }

      /* "MACS2/IO/CallPeakUnit.pyx":1923
 * 
 *                 # rewind window_size
 *                 for i in range(prev_i, 0, -1):             # <<<<<<<<<<<<<<
 *                     if plus[prev_i] - plus[i] >= window_size:
 *                         break
 */
      __Pyx_TraceLine(1923,0,__PYX_ERR(0, 1923, __pyx_L1_error))
      for (__pyx_t_19 = __pyx_v_prev_i; __pyx_t_19 > 0; __pyx_t_19-=1) {
        __pyx_v_i = __pyx_t_19;

        /* "MACS2/IO/CallPeakUnit.pyx":1924
 *                 # rewind window_size
 *                 for i in range(prev_i, 0, -1):
 *                     if plus[prev_i] - plus[i] >= window_size:             # <<<<<<<<<<<<<<
 *                         break
 *                 prev_i = i
 */
        __Pyx_TraceLine(1924,0,__PYX_ERR(0, 1924, __pyx_L1_error))
        __pyx_t_1 = __Pyx_GetItemInt(((PyObject *)__pyx_v_plus), __pyx_v_prev_i, long, 1, __Pyx_PyInt_From_long, 0, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1924, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_5 = __Pyx_GetItemInt(((PyObject *)__pyx_v_plus), __pyx_v_i, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1924, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_5);
        __pyx_t_8 = PyNumber_Subtract(__pyx_t_1, __pyx_t_5); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1924, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_8);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_window_size); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1924, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_5);
        __pyx_t_1 = PyObject_RichCompare(__pyx_t_8, __pyx_t_5, Py_GE); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1924, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        __pyx_t_11 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1924, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        if (__pyx_t_11) {

          /* "MACS2/IO/CallPeakUnit.pyx":1925
 *                 for i in range(prev_i, 0, -1):
 *                     if plus[prev_i] - plus[i] >= window_size:
 *                         break             # <<<<<<<<<<<<<<
 *                 prev_i = i
 * 
 */
          __Pyx_TraceLine(1925,0,__PYX_ERR(0, 1925, __pyx_L1_error))
          goto __pyx_L23_break;

          /* "MACS2/IO/CallPeakUnit.pyx":1924
 *                 # rewind window_size
 *                 for i in range(prev_i, 0, -1):
 *                     if plus[prev_i] - plus[i] >= window_size:             # <<<<<<<<<<<<<<
 *                         break
 *                 prev_i = i
 */
        }
      }
      __pyx_L23_break:;

      /* "MACS2/IO/CallPeakUnit.pyx":1926
 *                     if plus[prev_i] - plus[i] >= window_size:
 *                         break
 *                 prev_i = i             # <<<<<<<<<<<<<<
 * 
 *                 for j in range(prev_j, 0, -1):
 */
      __Pyx_TraceLine(1926,0,__PYX_ERR(0, 1926, __pyx_L1_error))
      __pyx_v_prev_i = __pyx_v_i;

      /* "MACS2/IO/CallPeakUnit.pyx":1928
 *                 prev_i = i
 * 
 *                 for j in range(prev_j, 0, -1):             # <<<<<<<<<<<<<<
 *                     if minus[prev_j] - minus[j] >= window_size:
 *                         break
 */
      __Pyx_TraceLine(1928,0,__PYX_ERR(0, 1928, __pyx_L1_error))
      for (__pyx_t_19 = __pyx_v_prev_j; __pyx_t_19 > 0; __pyx_t_19-=1) {
        __pyx_v_j = __pyx_t_19;

        /* "MACS2/IO/CallPeakUnit.pyx":1929
 * 
 *                 for j in range(prev_j, 0, -1):
 *                     if minus[prev_j] - minus[j] >= window_size:             # <<<<<<<<<<<<<<
 *                         break
 *                 prev_j = j
 */
        __Pyx_TraceLine(1929,0,__PYX_ERR(0, 1929, __pyx_L1_error))
        __pyx_t_1 = __Pyx_GetItemInt(((PyObject *)__pyx_v_minus), __pyx_v_prev_j, long, 1, __Pyx_PyInt_From_long, 0, 1, 1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1929, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_1);
        __pyx_t_5 = __Pyx_GetItemInt(((PyObject *)__pyx_v_minus), __pyx_v_j, __pyx_t_5numpy_int32_t, 1, __Pyx_PyInt_From_npy_int32, 0, 1, 1); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1929, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_5);
        __pyx_t_8 = PyNumber_Subtract(__pyx_t_1, __pyx_t_5); if (unlikely(!__pyx_t_8)) __PYX_ERR(0, 1929, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_8);
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        __pyx_t_5 = __Pyx_PyInt_From_npy_int32(__pyx_v_window_size); if (unlikely(!__pyx_t_5)) __PYX_ERR(0, 1929, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_5);
        __pyx_t_1 = PyObject_RichCompare(__pyx_t_8, __pyx_t_5, Py_GE); __Pyx_XGOTREF(__pyx_t_1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1929, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
        __Pyx_DECREF(__pyx_t_5); __pyx_t_5 = 0;
        __pyx_t_11 = __Pyx_PyObject_IsTrue(__pyx_t_1); if (unlikely(__pyx_t_11 < 0)) __PYX_ERR(0, 1929, __pyx_L1_error)
        __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
        if (__pyx_t_11) {

          /* "MACS2/IO/CallPeakUnit.pyx":1930
 *                 for j in range(prev_j, 0, -1):
 *                     if minus[prev_j] - minus[j] >= window_size:
 *                         break             # <<<<<<<<<<<<<<
 *                 prev_j = j
 *                 # end of a loop
 */
          __Pyx_TraceLine(1930,0,__PYX_ERR(0, 1930, __pyx_L1_error))
          goto __pyx_L26_break;

          /* "MACS2/IO/CallPeakUnit.pyx":1929
 * 
 *                 for j in range(prev_j, 0, -1):
 *                     if minus[prev_j] - minus[j] >= window_size:             # <<<<<<<<<<<<<<
 *                         break
 *                 prev_j = j
 */
        }
      }
      __pyx_L26_break:;

      /* "MACS2/IO/CallPeakUnit.pyx":1931
 *                     if minus[prev_j] - minus[j] >= window_size:
 *                         break
 *                 prev_j = j             # <<<<<<<<<<<<<<
 *                 # end of a loop
 *         return ret_peaks
 */
      __Pyx_TraceLine(1931,0,__PYX_ERR(0, 1931, __pyx_L1_error))
      __pyx_v_prev_j = __pyx_v_j;
    }
  }

  /* "MACS2/IO/CallPeakUnit.pyx":1933
 *                 prev_j = j
 *                 # end of a loop
 *         return ret_peaks             # <<<<<<<<<<<<<<
 * 
 */
  __Pyx_TraceLine(1933,0,__PYX_ERR(0, 1933, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(__pyx_v_ret_peaks);
  __pyx_r = __pyx_v_ret_peaks;
  goto __pyx_L0;

  /* "MACS2/IO/CallPeakUnit.pyx":1838
 *         return bpeaks
 * 
 *     cpdef refine_peak_from_tags_distribution ( self, peaks, int32_t window_size = 100, float32_t cutoff = 5 ):             # <<<<<<<<<<<<<<
 *         """Extract tags in peak, then apply func on extracted tags.
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.refine_peak_from_tags_distribution", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_plus);
  __Pyx_XDECREF((PyObject *)__pyx_v_minus);
  __Pyx_XDECREF((PyObject *)__pyx_v_rt_plus);
  __Pyx_XDECREF((PyObject *)__pyx_v_rt_minus);
  __Pyx_XDECREF(__pyx_v_chrom);
  __Pyx_XDECREF(__pyx_v_pchrnames);
  __Pyx_XDECREF(__pyx_v_chrnames);
  __Pyx_XDECREF(__pyx_v_temp);
  __Pyx_XDECREF(__pyx_v_retval);
  __Pyx_XDECREF(__pyx_v_cpeaks);
  __Pyx_XDECREF((PyObject *)__pyx_v_adjusted_summits);
  __Pyx_XDECREF((PyObject *)__pyx_v_passflags);
  __Pyx_XDECREF(__pyx_v_ret_peaks);
  __Pyx_XDECREF(__pyx_v_thispeak);
  __Pyx_XDECREF(__pyx_v_adjusted_summit);
  __Pyx_XDECREF(__pyx_v_passflag);
  __Pyx_XDECREF(__pyx_v_tmppeak);
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_13refine_peak_from_tags_distribution(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds); /*proto*/
static char __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_12refine_peak_from_tags_distribution[] = "Extract tags in peak, then apply func on extracted tags.\n        \n        peaks: redefined regions to extract raw tags in PeakIO type: check cPeakIO.pyx.\n\n        window_size: this will be passed to func.\n\n        cutoff: this will be passed to func.\n\n        func needs the fixed number of parameters, so it's not flexible. Here is an example:\n\n        wtd_find_summit(chrom, plus, minus, peak_start, peak_end, name , window_size, cutoff):\n\n        ";
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_13refine_peak_from_tags_distribution(PyObject *__pyx_v_self, PyObject *__pyx_args, PyObject *__pyx_kwds) {
  PyObject *__pyx_v_peaks = 0;
  __pyx_t_5numpy_int32_t __pyx_v_window_size;
  __pyx_t_5numpy_float32_t __pyx_v_cutoff;
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("refine_peak_from_tags_distribution (wrapper)", 0);
  {
    static PyObject **__pyx_pyargnames[] = {&__pyx_n_s_peaks,&__pyx_n_s_window_size,&__pyx_n_s_cutoff,0};
    PyObject* values[3] = {0,0,0};
    if (unlikely(__pyx_kwds)) {
      Py_ssize_t kw_args;
      const Py_ssize_t pos_args = PyTuple_GET_SIZE(__pyx_args);
      switch (pos_args) {
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        CYTHON_FALLTHROUGH;
        case  0: break;
        default: goto __pyx_L5_argtuple_error;
      }
      kw_args = PyDict_Size(__pyx_kwds);
      switch (pos_args) {
        case  0:
        if (likely((values[0] = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_peaks)) != 0)) kw_args--;
        else goto __pyx_L5_argtuple_error;
        CYTHON_FALLTHROUGH;
        case  1:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_window_size);
          if (value) { values[1] = value; kw_args--; }
        }
        CYTHON_FALLTHROUGH;
        case  2:
        if (kw_args > 0) {
          PyObject* value = __Pyx_PyDict_GetItemStr(__pyx_kwds, __pyx_n_s_cutoff);
          if (value) { values[2] = value; kw_args--; }
        }
      }
      if (unlikely(kw_args > 0)) {
        if (unlikely(__Pyx_ParseOptionalKeywords(__pyx_kwds, __pyx_pyargnames, 0, values, pos_args, "refine_peak_from_tags_distribution") < 0)) __PYX_ERR(0, 1838, __pyx_L3_error)
      }
    } else {
      switch (PyTuple_GET_SIZE(__pyx_args)) {
        case  3: values[2] = PyTuple_GET_ITEM(__pyx_args, 2);
        CYTHON_FALLTHROUGH;
        case  2: values[1] = PyTuple_GET_ITEM(__pyx_args, 1);
        CYTHON_FALLTHROUGH;
        case  1: values[0] = PyTuple_GET_ITEM(__pyx_args, 0);
        break;
        default: goto __pyx_L5_argtuple_error;
      }
    }
    __pyx_v_peaks = values[0];
    if (values[1]) {
      __pyx_v_window_size = __Pyx_PyInt_As_npy_int32(values[1]); if (unlikely((__pyx_v_window_size == ((npy_int32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1838, __pyx_L3_error)
    } else {
      __pyx_v_window_size = ((__pyx_t_5numpy_int32_t)0x64);
    }
    if (values[2]) {
      __pyx_v_cutoff = __pyx_PyFloat_AsFloat(values[2]); if (unlikely((__pyx_v_cutoff == ((npy_float32)-1)) && PyErr_Occurred())) __PYX_ERR(0, 1838, __pyx_L3_error)
    } else {
      __pyx_v_cutoff = ((__pyx_t_5numpy_float32_t)5.0);
    }
  }
  goto __pyx_L4_argument_unpacking_done;
  __pyx_L5_argtuple_error:;
  __Pyx_RaiseArgtupleInvalid("refine_peak_from_tags_distribution", 0, 1, 3, PyTuple_GET_SIZE(__pyx_args)); __PYX_ERR(0, 1838, __pyx_L3_error)
  __pyx_L3_error:;
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.refine_peak_from_tags_distribution", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __Pyx_RefNannyFinishContext();
  return NULL;
  __pyx_L4_argument_unpacking_done:;
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_12refine_peak_from_tags_distribution(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self), __pyx_v_peaks, __pyx_v_window_size, __pyx_v_cutoff);

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_12refine_peak_from_tags_distribution(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, PyObject *__pyx_v_peaks, __pyx_t_5numpy_int32_t __pyx_v_window_size, __pyx_t_5numpy_float32_t __pyx_v_cutoff) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution __pyx_t_2;
  __Pyx_RefNannySetupContext("refine_peak_from_tags_distribution", 0);
  __Pyx_TraceCall("refine_peak_from_tags_distribution (wrapper)", __pyx_f[0], 1838, 0, __PYX_ERR(0, 1838, __pyx_L1_error));
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_2.__pyx_n = 2;
  __pyx_t_2.window_size = __pyx_v_window_size;
  __pyx_t_2.cutoff = __pyx_v_cutoff;
  __pyx_t_1 = __pyx_vtabptr_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments->refine_peak_from_tags_distribution(__pyx_v_self, __pyx_v_peaks, 1, &__pyx_t_2); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 1838, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.refine_peak_from_tags_distribution", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 * def __setstate_cython__(self, __pyx_state):
 */

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_15__reduce_cython__(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused); /*proto*/
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_15__reduce_cython__(PyObject *__pyx_v_self, CYTHON_UNUSED PyObject *unused) {
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__reduce_cython__ (wrapper)", 0);
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_14__reduce_cython__(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_14__reduce_cython__(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("__reduce_cython__", 0);
  __Pyx_TraceCall("__reduce_cython__", __pyx_f[1], 1, 0, __PYX_ERR(1, 1, __pyx_L1_error));

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 */
  __Pyx_TraceLine(2,0,__PYX_ERR(1, 2, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_TypeError, __pyx_tuple__14, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 2, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_Raise(__pyx_t_1, 0, 0, 0);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __PYX_ERR(1, 2, __pyx_L1_error)

  /* "(tree fragment)":1
 * def __reduce_cython__(self):             # <<<<<<<<<<<<<<
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 * def __setstate_cython__(self, __pyx_state):
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__reduce_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 */

/* Python wrapper */
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_17__setstate_cython__(PyObject *__pyx_v_self, PyObject *__pyx_v___pyx_state); /*proto*/
static PyObject *__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_17__setstate_cython__(PyObject *__pyx_v_self, PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = 0;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__setstate_cython__ (wrapper)", 0);
  __pyx_r = __pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_16__setstate_cython__(((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)__pyx_v_self), ((PyObject *)__pyx_v___pyx_state));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static PyObject *__pyx_pf_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_16__setstate_cython__(CYTHON_UNUSED struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *__pyx_v_self, CYTHON_UNUSED PyObject *__pyx_v___pyx_state) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("__setstate_cython__", 0);
  __Pyx_TraceCall("__setstate_cython__", __pyx_f[1], 3, 0, __PYX_ERR(1, 3, __pyx_L1_error));

  /* "(tree fragment)":4
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")             # <<<<<<<<<<<<<<
 */
  __Pyx_TraceLine(4,0,__PYX_ERR(1, 4, __pyx_L1_error))
  __pyx_t_1 = __Pyx_PyObject_Call(__pyx_builtin_TypeError, __pyx_tuple__15, NULL); if (unlikely(!__pyx_t_1)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_Raise(__pyx_t_1, 0, 0, 0);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __PYX_ERR(1, 4, __pyx_L1_error)

  /* "(tree fragment)":3
 * def __reduce_cython__(self):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 * def __setstate_cython__(self, __pyx_state):             # <<<<<<<<<<<<<<
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("MACS2.IO.CallPeakUnit.CallerFromAlignments.__setstate_cython__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":258
 *         # experimental exception made for __getbuffer__ and __releasebuffer__
 *         # -- the details of this may change.
 *         def __getbuffer__(ndarray self, Py_buffer* info, int flags):             # <<<<<<<<<<<<<<
 *             # This implementation of getbuffer is geared towards Cython
 *             # requirements, and does not yet fulfill the PEP.
 */

/* Python wrapper */
static CYTHON_UNUSED int __pyx_pw_5numpy_7ndarray_1__getbuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags); /*proto*/
static CYTHON_UNUSED int __pyx_pw_5numpy_7ndarray_1__getbuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags) {
  int __pyx_r;
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__getbuffer__ (wrapper)", 0);
  __pyx_r = __pyx_pf_5numpy_7ndarray___getbuffer__(((PyArrayObject *)__pyx_v_self), ((Py_buffer *)__pyx_v_info), ((int)__pyx_v_flags));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

static int __pyx_pf_5numpy_7ndarray___getbuffer__(PyArrayObject *__pyx_v_self, Py_buffer *__pyx_v_info, int __pyx_v_flags) {
  int __pyx_v_i;
  int __pyx_v_ndim;
  int __pyx_v_endian_detector;
  int __pyx_v_little_endian;
  int __pyx_v_t;
  char *__pyx_v_f;
  PyArray_Descr *__pyx_v_descr = 0;
  int __pyx_v_offset;
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  int __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  int __pyx_t_5;
  int __pyx_t_6;
  PyArray_Descr *__pyx_t_7;
  PyObject *__pyx_t_8 = NULL;
  char *__pyx_t_9;
  if (__pyx_v_info == NULL) {
    PyErr_SetString(PyExc_BufferError, "PyObject_GetBuffer: view==NULL argument is obsolete");
    return -1;
  }
  __Pyx_RefNannySetupContext("__getbuffer__", 0);
  __pyx_v_info->obj = Py_None; __Pyx_INCREF(Py_None);
  __Pyx_GIVEREF(__pyx_v_info->obj);
  __Pyx_TraceCall("__getbuffer__", __pyx_f[2], 258, 0, __PYX_ERR(2, 258, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":265
 * 
 *             cdef int i, ndim
 *             cdef int endian_detector = 1             # <<<<<<<<<<<<<<
 *             cdef bint little_endian = ((<char*>&endian_detector)[0] != 0)
 * 
 */
  __Pyx_TraceLine(265,0,__PYX_ERR(2, 265, __pyx_L1_error))
  __pyx_v_endian_detector = 1;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":266
 *             cdef int i, ndim
 *             cdef int endian_detector = 1
 *             cdef bint little_endian = ((<char*>&endian_detector)[0] != 0)             # <<<<<<<<<<<<<<
 * 
 *             ndim = PyArray_NDIM(self)
 */
  __Pyx_TraceLine(266,0,__PYX_ERR(2, 266, __pyx_L1_error))
  __pyx_v_little_endian = ((((char *)(&__pyx_v_endian_detector))[0]) != 0);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":268
 *             cdef bint little_endian = ((<char*>&endian_detector)[0] != 0)
 * 
 *             ndim = PyArray_NDIM(self)             # <<<<<<<<<<<<<<
 * 
 *             if ((flags & pybuf.PyBUF_C_CONTIGUOUS == pybuf.PyBUF_C_CONTIGUOUS)
 */
  __Pyx_TraceLine(268,0,__PYX_ERR(2, 268, __pyx_L1_error))
  __pyx_v_ndim = PyArray_NDIM(__pyx_v_self);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":270
 *             ndim = PyArray_NDIM(self)
 * 
 *             if ((flags & pybuf.PyBUF_C_CONTIGUOUS == pybuf.PyBUF_C_CONTIGUOUS)             # <<<<<<<<<<<<<<
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_C_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not C contiguous")
 */
  __Pyx_TraceLine(270,0,__PYX_ERR(2, 270, __pyx_L1_error))
  __pyx_t_2 = (((__pyx_v_flags & PyBUF_C_CONTIGUOUS) == PyBUF_C_CONTIGUOUS) != 0);
  if (__pyx_t_2) {
  } else {
    __pyx_t_1 = __pyx_t_2;
    goto __pyx_L4_bool_binop_done;
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":271
 * 
 *             if ((flags & pybuf.PyBUF_C_CONTIGUOUS == pybuf.PyBUF_C_CONTIGUOUS)
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_C_CONTIGUOUS)):             # <<<<<<<<<<<<<<
 *                 raise ValueError(u"ndarray is not C contiguous")
 * 
 */
  __Pyx_TraceLine(271,0,__PYX_ERR(2, 271, __pyx_L1_error))
  __pyx_t_2 = ((!(PyArray_CHKFLAGS(__pyx_v_self, NPY_ARRAY_C_CONTIGUOUS) != 0)) != 0);
  __pyx_t_1 = __pyx_t_2;
  __pyx_L4_bool_binop_done:;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":270
 *             ndim = PyArray_NDIM(self)
 * 
 *             if ((flags & pybuf.PyBUF_C_CONTIGUOUS == pybuf.PyBUF_C_CONTIGUOUS)             # <<<<<<<<<<<<<<
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_C_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not C contiguous")
 */
  __Pyx_TraceLine(270,0,__PYX_ERR(2, 270, __pyx_L1_error))
  if (unlikely(__pyx_t_1)) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":272
 *             if ((flags & pybuf.PyBUF_C_CONTIGUOUS == pybuf.PyBUF_C_CONTIGUOUS)
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_C_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not C contiguous")             # <<<<<<<<<<<<<<
 * 
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)
 */
    __Pyx_TraceLine(272,0,__PYX_ERR(2, 272, __pyx_L1_error))
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__16, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 272, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(2, 272, __pyx_L1_error)

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":270
 *             ndim = PyArray_NDIM(self)
 * 
 *             if ((flags & pybuf.PyBUF_C_CONTIGUOUS == pybuf.PyBUF_C_CONTIGUOUS)             # <<<<<<<<<<<<<<
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_C_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not C contiguous")
 */
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":274
 *                 raise ValueError(u"ndarray is not C contiguous")
 * 
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)             # <<<<<<<<<<<<<<
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_F_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not Fortran contiguous")
 */
  __Pyx_TraceLine(274,0,__PYX_ERR(2, 274, __pyx_L1_error))
  __pyx_t_2 = (((__pyx_v_flags & PyBUF_F_CONTIGUOUS) == PyBUF_F_CONTIGUOUS) != 0);
  if (__pyx_t_2) {
  } else {
    __pyx_t_1 = __pyx_t_2;
    goto __pyx_L7_bool_binop_done;
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":275
 * 
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_F_CONTIGUOUS)):             # <<<<<<<<<<<<<<
 *                 raise ValueError(u"ndarray is not Fortran contiguous")
 * 
 */
  __Pyx_TraceLine(275,0,__PYX_ERR(2, 275, __pyx_L1_error))
  __pyx_t_2 = ((!(PyArray_CHKFLAGS(__pyx_v_self, NPY_ARRAY_F_CONTIGUOUS) != 0)) != 0);
  __pyx_t_1 = __pyx_t_2;
  __pyx_L7_bool_binop_done:;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":274
 *                 raise ValueError(u"ndarray is not C contiguous")
 * 
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)             # <<<<<<<<<<<<<<
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_F_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not Fortran contiguous")
 */
  __Pyx_TraceLine(274,0,__PYX_ERR(2, 274, __pyx_L1_error))
  if (unlikely(__pyx_t_1)) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":276
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_F_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not Fortran contiguous")             # <<<<<<<<<<<<<<
 * 
 *             info.buf = PyArray_DATA(self)
 */
    __Pyx_TraceLine(276,0,__PYX_ERR(2, 276, __pyx_L1_error))
    __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__17, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 276, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_Raise(__pyx_t_3, 0, 0, 0);
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __PYX_ERR(2, 276, __pyx_L1_error)

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":274
 *                 raise ValueError(u"ndarray is not C contiguous")
 * 
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)             # <<<<<<<<<<<<<<
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_F_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not Fortran contiguous")
 */
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":278
 *                 raise ValueError(u"ndarray is not Fortran contiguous")
 * 
 *             info.buf = PyArray_DATA(self)             # <<<<<<<<<<<<<<
 *             info.ndim = ndim
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):
 */
  __Pyx_TraceLine(278,0,__PYX_ERR(2, 278, __pyx_L1_error))
  __pyx_v_info->buf = PyArray_DATA(__pyx_v_self);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":279
 * 
 *             info.buf = PyArray_DATA(self)
 *             info.ndim = ndim             # <<<<<<<<<<<<<<
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):
 *                 # Allocate new buffer for strides and shape info.
 */
  __Pyx_TraceLine(279,0,__PYX_ERR(2, 279, __pyx_L1_error))
  __pyx_v_info->ndim = __pyx_v_ndim;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":280
 *             info.buf = PyArray_DATA(self)
 *             info.ndim = ndim
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):             # <<<<<<<<<<<<<<
 *                 # Allocate new buffer for strides and shape info.
 *                 # This is allocated as one block, strides first.
 */
  __Pyx_TraceLine(280,0,__PYX_ERR(2, 280, __pyx_L1_error))
  __pyx_t_1 = (((sizeof(npy_intp)) != (sizeof(Py_ssize_t))) != 0);
  if (__pyx_t_1) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":283
 *                 # Allocate new buffer for strides and shape info.
 *                 # This is allocated as one block, strides first.
 *                 info.strides = <Py_ssize_t*>PyObject_Malloc(sizeof(Py_ssize_t) * 2 * <size_t>ndim)             # <<<<<<<<<<<<<<
 *                 info.shape = info.strides + ndim
 *                 for i in range(ndim):
 */
    __Pyx_TraceLine(283,0,__PYX_ERR(2, 283, __pyx_L1_error))
    __pyx_v_info->strides = ((Py_ssize_t *)PyObject_Malloc((((sizeof(Py_ssize_t)) * 2) * ((size_t)__pyx_v_ndim))));

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":284
 *                 # This is allocated as one block, strides first.
 *                 info.strides = <Py_ssize_t*>PyObject_Malloc(sizeof(Py_ssize_t) * 2 * <size_t>ndim)
 *                 info.shape = info.strides + ndim             # <<<<<<<<<<<<<<
 *                 for i in range(ndim):
 *                     info.strides[i] = PyArray_STRIDES(self)[i]
 */
    __Pyx_TraceLine(284,0,__PYX_ERR(2, 284, __pyx_L1_error))
    __pyx_v_info->shape = (__pyx_v_info->strides + __pyx_v_ndim);

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":285
 *                 info.strides = <Py_ssize_t*>PyObject_Malloc(sizeof(Py_ssize_t) * 2 * <size_t>ndim)
 *                 info.shape = info.strides + ndim
 *                 for i in range(ndim):             # <<<<<<<<<<<<<<
 *                     info.strides[i] = PyArray_STRIDES(self)[i]
 *                     info.shape[i] = PyArray_DIMS(self)[i]
 */
    __Pyx_TraceLine(285,0,__PYX_ERR(2, 285, __pyx_L1_error))
    __pyx_t_4 = __pyx_v_ndim;
    __pyx_t_5 = __pyx_t_4;
    for (__pyx_t_6 = 0; __pyx_t_6 < __pyx_t_5; __pyx_t_6+=1) {
      __pyx_v_i = __pyx_t_6;

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":286
 *                 info.shape = info.strides + ndim
 *                 for i in range(ndim):
 *                     info.strides[i] = PyArray_STRIDES(self)[i]             # <<<<<<<<<<<<<<
 *                     info.shape[i] = PyArray_DIMS(self)[i]
 *             else:
 */
      __Pyx_TraceLine(286,0,__PYX_ERR(2, 286, __pyx_L1_error))
      (__pyx_v_info->strides[__pyx_v_i]) = (PyArray_STRIDES(__pyx_v_self)[__pyx_v_i]);

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":287
 *                 for i in range(ndim):
 *                     info.strides[i] = PyArray_STRIDES(self)[i]
 *                     info.shape[i] = PyArray_DIMS(self)[i]             # <<<<<<<<<<<<<<
 *             else:
 *                 info.strides = <Py_ssize_t*>PyArray_STRIDES(self)
 */
      __Pyx_TraceLine(287,0,__PYX_ERR(2, 287, __pyx_L1_error))
      (__pyx_v_info->shape[__pyx_v_i]) = (PyArray_DIMS(__pyx_v_self)[__pyx_v_i]);
    }

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":280
 *             info.buf = PyArray_DATA(self)
 *             info.ndim = ndim
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):             # <<<<<<<<<<<<<<
 *                 # Allocate new buffer for strides and shape info.
 *                 # This is allocated as one block, strides first.
 */
    goto __pyx_L9;
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":289
 *                     info.shape[i] = PyArray_DIMS(self)[i]
 *             else:
 *                 info.strides = <Py_ssize_t*>PyArray_STRIDES(self)             # <<<<<<<<<<<<<<
 *                 info.shape = <Py_ssize_t*>PyArray_DIMS(self)
 *             info.suboffsets = NULL
 */
  __Pyx_TraceLine(289,0,__PYX_ERR(2, 289, __pyx_L1_error))
  /*else*/ {
    __pyx_v_info->strides = ((Py_ssize_t *)PyArray_STRIDES(__pyx_v_self));

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":290
 *             else:
 *                 info.strides = <Py_ssize_t*>PyArray_STRIDES(self)
 *                 info.shape = <Py_ssize_t*>PyArray_DIMS(self)             # <<<<<<<<<<<<<<
 *             info.suboffsets = NULL
 *             info.itemsize = PyArray_ITEMSIZE(self)
 */
    __Pyx_TraceLine(290,0,__PYX_ERR(2, 290, __pyx_L1_error))
    __pyx_v_info->shape = ((Py_ssize_t *)PyArray_DIMS(__pyx_v_self));
  }
  __pyx_L9:;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":291
 *                 info.strides = <Py_ssize_t*>PyArray_STRIDES(self)
 *                 info.shape = <Py_ssize_t*>PyArray_DIMS(self)
 *             info.suboffsets = NULL             # <<<<<<<<<<<<<<
 *             info.itemsize = PyArray_ITEMSIZE(self)
 *             info.readonly = not PyArray_ISWRITEABLE(self)
 */
  __Pyx_TraceLine(291,0,__PYX_ERR(2, 291, __pyx_L1_error))
  __pyx_v_info->suboffsets = NULL;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":292
 *                 info.shape = <Py_ssize_t*>PyArray_DIMS(self)
 *             info.suboffsets = NULL
 *             info.itemsize = PyArray_ITEMSIZE(self)             # <<<<<<<<<<<<<<
 *             info.readonly = not PyArray_ISWRITEABLE(self)
 * 
 */
  __Pyx_TraceLine(292,0,__PYX_ERR(2, 292, __pyx_L1_error))
  __pyx_v_info->itemsize = PyArray_ITEMSIZE(__pyx_v_self);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":293
 *             info.suboffsets = NULL
 *             info.itemsize = PyArray_ITEMSIZE(self)
 *             info.readonly = not PyArray_ISWRITEABLE(self)             # <<<<<<<<<<<<<<
 * 
 *             cdef int t
 */
  __Pyx_TraceLine(293,0,__PYX_ERR(2, 293, __pyx_L1_error))
  __pyx_v_info->readonly = (!(PyArray_ISWRITEABLE(__pyx_v_self) != 0));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":296
 * 
 *             cdef int t
 *             cdef char* f = NULL             # <<<<<<<<<<<<<<
 *             cdef dtype descr = <dtype>PyArray_DESCR(self)
 *             cdef int offset
 */
  __Pyx_TraceLine(296,0,__PYX_ERR(2, 296, __pyx_L1_error))
  __pyx_v_f = NULL;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":297
 *             cdef int t
 *             cdef char* f = NULL
 *             cdef dtype descr = <dtype>PyArray_DESCR(self)             # <<<<<<<<<<<<<<
 *             cdef int offset
 * 
 */
  __Pyx_TraceLine(297,0,__PYX_ERR(2, 297, __pyx_L1_error))
  __pyx_t_7 = PyArray_DESCR(__pyx_v_self);
  __pyx_t_3 = ((PyObject *)__pyx_t_7);
  __Pyx_INCREF(__pyx_t_3);
  __pyx_v_descr = ((PyArray_Descr *)__pyx_t_3);
  __pyx_t_3 = 0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":300
 *             cdef int offset
 * 
 *             info.obj = self             # <<<<<<<<<<<<<<
 * 
 *             if not PyDataType_HASFIELDS(descr):
 */
  __Pyx_TraceLine(300,0,__PYX_ERR(2, 300, __pyx_L1_error))
  __Pyx_INCREF(((PyObject *)__pyx_v_self));
  __Pyx_GIVEREF(((PyObject *)__pyx_v_self));
  __Pyx_GOTREF(__pyx_v_info->obj);
  __Pyx_DECREF(__pyx_v_info->obj);
  __pyx_v_info->obj = ((PyObject *)__pyx_v_self);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":302
 *             info.obj = self
 * 
 *             if not PyDataType_HASFIELDS(descr):             # <<<<<<<<<<<<<<
 *                 t = descr.type_num
 *                 if ((descr.byteorder == c'>' and little_endian) or
 */
  __Pyx_TraceLine(302,0,__PYX_ERR(2, 302, __pyx_L1_error))
  __pyx_t_1 = ((!(PyDataType_HASFIELDS(__pyx_v_descr) != 0)) != 0);
  if (__pyx_t_1) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":303
 * 
 *             if not PyDataType_HASFIELDS(descr):
 *                 t = descr.type_num             # <<<<<<<<<<<<<<
 *                 if ((descr.byteorder == c'>' and little_endian) or
 *                     (descr.byteorder == c'<' and not little_endian)):
 */
    __Pyx_TraceLine(303,0,__PYX_ERR(2, 303, __pyx_L1_error))
    __pyx_t_4 = __pyx_v_descr->type_num;
    __pyx_v_t = __pyx_t_4;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":304
 *             if not PyDataType_HASFIELDS(descr):
 *                 t = descr.type_num
 *                 if ((descr.byteorder == c'>' and little_endian) or             # <<<<<<<<<<<<<<
 *                     (descr.byteorder == c'<' and not little_endian)):
 *                     raise ValueError(u"Non-native byte order not supported")
 */
    __Pyx_TraceLine(304,0,__PYX_ERR(2, 304, __pyx_L1_error))
    __pyx_t_2 = ((__pyx_v_descr->byteorder == '>') != 0);
    if (!__pyx_t_2) {
      goto __pyx_L15_next_or;
    } else {
    }
    __pyx_t_2 = (__pyx_v_little_endian != 0);
    if (!__pyx_t_2) {
    } else {
      __pyx_t_1 = __pyx_t_2;
      goto __pyx_L14_bool_binop_done;
    }
    __pyx_L15_next_or:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":305
 *                 t = descr.type_num
 *                 if ((descr.byteorder == c'>' and little_endian) or
 *                     (descr.byteorder == c'<' and not little_endian)):             # <<<<<<<<<<<<<<
 *                     raise ValueError(u"Non-native byte order not supported")
 *                 if   t == NPY_BYTE:        f = "b"
 */
    __Pyx_TraceLine(305,0,__PYX_ERR(2, 305, __pyx_L1_error))
    __pyx_t_2 = ((__pyx_v_descr->byteorder == '<') != 0);
    if (__pyx_t_2) {
    } else {
      __pyx_t_1 = __pyx_t_2;
      goto __pyx_L14_bool_binop_done;
    }
    __pyx_t_2 = ((!(__pyx_v_little_endian != 0)) != 0);
    __pyx_t_1 = __pyx_t_2;
    __pyx_L14_bool_binop_done:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":304
 *             if not PyDataType_HASFIELDS(descr):
 *                 t = descr.type_num
 *                 if ((descr.byteorder == c'>' and little_endian) or             # <<<<<<<<<<<<<<
 *                     (descr.byteorder == c'<' and not little_endian)):
 *                     raise ValueError(u"Non-native byte order not supported")
 */
    __Pyx_TraceLine(304,0,__PYX_ERR(2, 304, __pyx_L1_error))
    if (unlikely(__pyx_t_1)) {

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":306
 *                 if ((descr.byteorder == c'>' and little_endian) or
 *                     (descr.byteorder == c'<' and not little_endian)):
 *                     raise ValueError(u"Non-native byte order not supported")             # <<<<<<<<<<<<<<
 *                 if   t == NPY_BYTE:        f = "b"
 *                 elif t == NPY_UBYTE:       f = "B"
 */
      __Pyx_TraceLine(306,0,__PYX_ERR(2, 306, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__18, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 306, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_Raise(__pyx_t_3, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __PYX_ERR(2, 306, __pyx_L1_error)

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":304
 *             if not PyDataType_HASFIELDS(descr):
 *                 t = descr.type_num
 *                 if ((descr.byteorder == c'>' and little_endian) or             # <<<<<<<<<<<<<<
 *                     (descr.byteorder == c'<' and not little_endian)):
 *                     raise ValueError(u"Non-native byte order not supported")
 */
    }

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":307
 *                     (descr.byteorder == c'<' and not little_endian)):
 *                     raise ValueError(u"Non-native byte order not supported")
 *                 if   t == NPY_BYTE:        f = "b"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_UBYTE:       f = "B"
 *                 elif t == NPY_SHORT:       f = "h"
 */
    __Pyx_TraceLine(307,0,__PYX_ERR(2, 307, __pyx_L1_error))
    switch (__pyx_v_t) {
      case NPY_BYTE:
      __pyx_v_f = ((char *)"b");
      break;
      case NPY_UBYTE:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":308
 *                     raise ValueError(u"Non-native byte order not supported")
 *                 if   t == NPY_BYTE:        f = "b"
 *                 elif t == NPY_UBYTE:       f = "B"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_SHORT:       f = "h"
 *                 elif t == NPY_USHORT:      f = "H"
 */
      __Pyx_TraceLine(308,0,__PYX_ERR(2, 308, __pyx_L1_error))
      __pyx_v_f = ((char *)"B");
      break;
      case NPY_SHORT:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":309
 *                 if   t == NPY_BYTE:        f = "b"
 *                 elif t == NPY_UBYTE:       f = "B"
 *                 elif t == NPY_SHORT:       f = "h"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_USHORT:      f = "H"
 *                 elif t == NPY_INT:         f = "i"
 */
      __Pyx_TraceLine(309,0,__PYX_ERR(2, 309, __pyx_L1_error))
      __pyx_v_f = ((char *)"h");
      break;
      case NPY_USHORT:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":310
 *                 elif t == NPY_UBYTE:       f = "B"
 *                 elif t == NPY_SHORT:       f = "h"
 *                 elif t == NPY_USHORT:      f = "H"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_INT:         f = "i"
 *                 elif t == NPY_UINT:        f = "I"
 */
      __Pyx_TraceLine(310,0,__PYX_ERR(2, 310, __pyx_L1_error))
      __pyx_v_f = ((char *)"H");
      break;
      case NPY_INT:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":311
 *                 elif t == NPY_SHORT:       f = "h"
 *                 elif t == NPY_USHORT:      f = "H"
 *                 elif t == NPY_INT:         f = "i"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_UINT:        f = "I"
 *                 elif t == NPY_LONG:        f = "l"
 */
      __Pyx_TraceLine(311,0,__PYX_ERR(2, 311, __pyx_L1_error))
      __pyx_v_f = ((char *)"i");
      break;
      case NPY_UINT:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":312
 *                 elif t == NPY_USHORT:      f = "H"
 *                 elif t == NPY_INT:         f = "i"
 *                 elif t == NPY_UINT:        f = "I"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_LONG:        f = "l"
 *                 elif t == NPY_ULONG:       f = "L"
 */
      __Pyx_TraceLine(312,0,__PYX_ERR(2, 312, __pyx_L1_error))
      __pyx_v_f = ((char *)"I");
      break;
      case NPY_LONG:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":313
 *                 elif t == NPY_INT:         f = "i"
 *                 elif t == NPY_UINT:        f = "I"
 *                 elif t == NPY_LONG:        f = "l"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_ULONG:       f = "L"
 *                 elif t == NPY_LONGLONG:    f = "q"
 */
      __Pyx_TraceLine(313,0,__PYX_ERR(2, 313, __pyx_L1_error))
      __pyx_v_f = ((char *)"l");
      break;
      case NPY_ULONG:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":314
 *                 elif t == NPY_UINT:        f = "I"
 *                 elif t == NPY_LONG:        f = "l"
 *                 elif t == NPY_ULONG:       f = "L"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_LONGLONG:    f = "q"
 *                 elif t == NPY_ULONGLONG:   f = "Q"
 */
      __Pyx_TraceLine(314,0,__PYX_ERR(2, 314, __pyx_L1_error))
      __pyx_v_f = ((char *)"L");
      break;
      case NPY_LONGLONG:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":315
 *                 elif t == NPY_LONG:        f = "l"
 *                 elif t == NPY_ULONG:       f = "L"
 *                 elif t == NPY_LONGLONG:    f = "q"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_ULONGLONG:   f = "Q"
 *                 elif t == NPY_FLOAT:       f = "f"
 */
      __Pyx_TraceLine(315,0,__PYX_ERR(2, 315, __pyx_L1_error))
      __pyx_v_f = ((char *)"q");
      break;
      case NPY_ULONGLONG:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":316
 *                 elif t == NPY_ULONG:       f = "L"
 *                 elif t == NPY_LONGLONG:    f = "q"
 *                 elif t == NPY_ULONGLONG:   f = "Q"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_FLOAT:       f = "f"
 *                 elif t == NPY_DOUBLE:      f = "d"
 */
      __Pyx_TraceLine(316,0,__PYX_ERR(2, 316, __pyx_L1_error))
      __pyx_v_f = ((char *)"Q");
      break;
      case NPY_FLOAT:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":317
 *                 elif t == NPY_LONGLONG:    f = "q"
 *                 elif t == NPY_ULONGLONG:   f = "Q"
 *                 elif t == NPY_FLOAT:       f = "f"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_DOUBLE:      f = "d"
 *                 elif t == NPY_LONGDOUBLE:  f = "g"
 */
      __Pyx_TraceLine(317,0,__PYX_ERR(2, 317, __pyx_L1_error))
      __pyx_v_f = ((char *)"f");
      break;
      case NPY_DOUBLE:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":318
 *                 elif t == NPY_ULONGLONG:   f = "Q"
 *                 elif t == NPY_FLOAT:       f = "f"
 *                 elif t == NPY_DOUBLE:      f = "d"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_LONGDOUBLE:  f = "g"
 *                 elif t == NPY_CFLOAT:      f = "Zf"
 */
      __Pyx_TraceLine(318,0,__PYX_ERR(2, 318, __pyx_L1_error))
      __pyx_v_f = ((char *)"d");
      break;
      case NPY_LONGDOUBLE:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":319
 *                 elif t == NPY_FLOAT:       f = "f"
 *                 elif t == NPY_DOUBLE:      f = "d"
 *                 elif t == NPY_LONGDOUBLE:  f = "g"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_CFLOAT:      f = "Zf"
 *                 elif t == NPY_CDOUBLE:     f = "Zd"
 */
      __Pyx_TraceLine(319,0,__PYX_ERR(2, 319, __pyx_L1_error))
      __pyx_v_f = ((char *)"g");
      break;
      case NPY_CFLOAT:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":320
 *                 elif t == NPY_DOUBLE:      f = "d"
 *                 elif t == NPY_LONGDOUBLE:  f = "g"
 *                 elif t == NPY_CFLOAT:      f = "Zf"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_CDOUBLE:     f = "Zd"
 *                 elif t == NPY_CLONGDOUBLE: f = "Zg"
 */
      __Pyx_TraceLine(320,0,__PYX_ERR(2, 320, __pyx_L1_error))
      __pyx_v_f = ((char *)"Zf");
      break;
      case NPY_CDOUBLE:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":321
 *                 elif t == NPY_LONGDOUBLE:  f = "g"
 *                 elif t == NPY_CFLOAT:      f = "Zf"
 *                 elif t == NPY_CDOUBLE:     f = "Zd"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_CLONGDOUBLE: f = "Zg"
 *                 elif t == NPY_OBJECT:      f = "O"
 */
      __Pyx_TraceLine(321,0,__PYX_ERR(2, 321, __pyx_L1_error))
      __pyx_v_f = ((char *)"Zd");
      break;
      case NPY_CLONGDOUBLE:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":322
 *                 elif t == NPY_CFLOAT:      f = "Zf"
 *                 elif t == NPY_CDOUBLE:     f = "Zd"
 *                 elif t == NPY_CLONGDOUBLE: f = "Zg"             # <<<<<<<<<<<<<<
 *                 elif t == NPY_OBJECT:      f = "O"
 *                 else:
 */
      __Pyx_TraceLine(322,0,__PYX_ERR(2, 322, __pyx_L1_error))
      __pyx_v_f = ((char *)"Zg");
      break;
      case NPY_OBJECT:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":323
 *                 elif t == NPY_CDOUBLE:     f = "Zd"
 *                 elif t == NPY_CLONGDOUBLE: f = "Zg"
 *                 elif t == NPY_OBJECT:      f = "O"             # <<<<<<<<<<<<<<
 *                 else:
 *                     raise ValueError(u"unknown dtype code in numpy.pxd (%d)" % t)
 */
      __Pyx_TraceLine(323,0,__PYX_ERR(2, 323, __pyx_L1_error))
      __pyx_v_f = ((char *)"O");
      break;
      default:

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":325
 *                 elif t == NPY_OBJECT:      f = "O"
 *                 else:
 *                     raise ValueError(u"unknown dtype code in numpy.pxd (%d)" % t)             # <<<<<<<<<<<<<<
 *                 info.format = f
 *                 return
 */
      __Pyx_TraceLine(325,0,__PYX_ERR(2, 325, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_int(__pyx_v_t); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 325, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_8 = PyUnicode_Format(__pyx_kp_u_unknown_dtype_code_in_numpy_pxd, __pyx_t_3); if (unlikely(!__pyx_t_8)) __PYX_ERR(2, 325, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_3 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_8); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 325, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __Pyx_Raise(__pyx_t_3, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __PYX_ERR(2, 325, __pyx_L1_error)
      break;
    }

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":326
 *                 else:
 *                     raise ValueError(u"unknown dtype code in numpy.pxd (%d)" % t)
 *                 info.format = f             # <<<<<<<<<<<<<<
 *                 return
 *             else:
 */
    __Pyx_TraceLine(326,0,__PYX_ERR(2, 326, __pyx_L1_error))
    __pyx_v_info->format = __pyx_v_f;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":327
 *                     raise ValueError(u"unknown dtype code in numpy.pxd (%d)" % t)
 *                 info.format = f
 *                 return             # <<<<<<<<<<<<<<
 *             else:
 *                 info.format = <char*>PyObject_Malloc(_buffer_format_string_len)
 */
    __Pyx_TraceLine(327,0,__PYX_ERR(2, 327, __pyx_L1_error))
    __pyx_r = 0;
    goto __pyx_L0;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":302
 *             info.obj = self
 * 
 *             if not PyDataType_HASFIELDS(descr):             # <<<<<<<<<<<<<<
 *                 t = descr.type_num
 *                 if ((descr.byteorder == c'>' and little_endian) or
 */
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":329
 *                 return
 *             else:
 *                 info.format = <char*>PyObject_Malloc(_buffer_format_string_len)             # <<<<<<<<<<<<<<
 *                 info.format[0] = c'^' # Native data types, manual alignment
 *                 offset = 0
 */
  __Pyx_TraceLine(329,0,__PYX_ERR(2, 329, __pyx_L1_error))
  /*else*/ {
    __pyx_v_info->format = ((char *)PyObject_Malloc(0xFF));

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":330
 *             else:
 *                 info.format = <char*>PyObject_Malloc(_buffer_format_string_len)
 *                 info.format[0] = c'^' # Native data types, manual alignment             # <<<<<<<<<<<<<<
 *                 offset = 0
 *                 f = _util_dtypestring(descr, info.format + 1,
 */
    __Pyx_TraceLine(330,0,__PYX_ERR(2, 330, __pyx_L1_error))
    (__pyx_v_info->format[0]) = '^';

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":331
 *                 info.format = <char*>PyObject_Malloc(_buffer_format_string_len)
 *                 info.format[0] = c'^' # Native data types, manual alignment
 *                 offset = 0             # <<<<<<<<<<<<<<
 *                 f = _util_dtypestring(descr, info.format + 1,
 *                                       info.format + _buffer_format_string_len,
 */
    __Pyx_TraceLine(331,0,__PYX_ERR(2, 331, __pyx_L1_error))
    __pyx_v_offset = 0;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":332
 *                 info.format[0] = c'^' # Native data types, manual alignment
 *                 offset = 0
 *                 f = _util_dtypestring(descr, info.format + 1,             # <<<<<<<<<<<<<<
 *                                       info.format + _buffer_format_string_len,
 *                                       &offset)
 */
    __Pyx_TraceLine(332,0,__PYX_ERR(2, 332, __pyx_L1_error))
    __pyx_t_9 = __pyx_f_5numpy__util_dtypestring(__pyx_v_descr, (__pyx_v_info->format + 1), (__pyx_v_info->format + 0xFF), (&__pyx_v_offset)); if (unlikely(__pyx_t_9 == ((char *)NULL))) __PYX_ERR(2, 332, __pyx_L1_error)
    __pyx_v_f = __pyx_t_9;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":335
 *                                       info.format + _buffer_format_string_len,
 *                                       &offset)
 *                 f[0] = c'\0' # Terminate format string             # <<<<<<<<<<<<<<
 * 
 *         def __releasebuffer__(ndarray self, Py_buffer* info):
 */
    __Pyx_TraceLine(335,0,__PYX_ERR(2, 335, __pyx_L1_error))
    (__pyx_v_f[0]) = '\x00';
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":258
 *         # experimental exception made for __getbuffer__ and __releasebuffer__
 *         # -- the details of this may change.
 *         def __getbuffer__(ndarray self, Py_buffer* info, int flags):             # <<<<<<<<<<<<<<
 *             # This implementation of getbuffer is geared towards Cython
 *             # requirements, and does not yet fulfill the PEP.
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_AddTraceback("numpy.ndarray.__getbuffer__", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  if (__pyx_v_info->obj != NULL) {
    __Pyx_GOTREF(__pyx_v_info->obj);
    __Pyx_DECREF(__pyx_v_info->obj); __pyx_v_info->obj = 0;
  }
  goto __pyx_L2;
  __pyx_L0:;
  if (__pyx_v_info->obj == Py_None) {
    __Pyx_GOTREF(__pyx_v_info->obj);
    __Pyx_DECREF(__pyx_v_info->obj); __pyx_v_info->obj = 0;
  }
  __pyx_L2:;
  __Pyx_XDECREF((PyObject *)__pyx_v_descr);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":337
 *                 f[0] = c'\0' # Terminate format string
 * 
 *         def __releasebuffer__(ndarray self, Py_buffer* info):             # <<<<<<<<<<<<<<
 *             if PyArray_HASFIELDS(self):
 *                 PyObject_Free(info.format)
 */

/* Python wrapper */
static CYTHON_UNUSED void __pyx_pw_5numpy_7ndarray_3__releasebuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info); /*proto*/
static CYTHON_UNUSED void __pyx_pw_5numpy_7ndarray_3__releasebuffer__(PyObject *__pyx_v_self, Py_buffer *__pyx_v_info) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__releasebuffer__ (wrapper)", 0);
  __pyx_pf_5numpy_7ndarray_2__releasebuffer__(((PyArrayObject *)__pyx_v_self), ((Py_buffer *)__pyx_v_info));

  /* function exit code */
  __Pyx_RefNannyFinishContext();
}

static void __pyx_pf_5numpy_7ndarray_2__releasebuffer__(PyArrayObject *__pyx_v_self, Py_buffer *__pyx_v_info) {
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  __Pyx_RefNannySetupContext("__releasebuffer__", 0);
  __Pyx_TraceCall("__releasebuffer__", __pyx_f[2], 337, 0, __PYX_ERR(2, 337, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":338
 * 
 *         def __releasebuffer__(ndarray self, Py_buffer* info):
 *             if PyArray_HASFIELDS(self):             # <<<<<<<<<<<<<<
 *                 PyObject_Free(info.format)
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):
 */
  __Pyx_TraceLine(338,0,__PYX_ERR(2, 338, __pyx_L1_error))
  __pyx_t_1 = (PyArray_HASFIELDS(__pyx_v_self) != 0);
  if (__pyx_t_1) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":339
 *         def __releasebuffer__(ndarray self, Py_buffer* info):
 *             if PyArray_HASFIELDS(self):
 *                 PyObject_Free(info.format)             # <<<<<<<<<<<<<<
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):
 *                 PyObject_Free(info.strides)
 */
    __Pyx_TraceLine(339,0,__PYX_ERR(2, 339, __pyx_L1_error))
    PyObject_Free(__pyx_v_info->format);

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":338
 * 
 *         def __releasebuffer__(ndarray self, Py_buffer* info):
 *             if PyArray_HASFIELDS(self):             # <<<<<<<<<<<<<<
 *                 PyObject_Free(info.format)
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):
 */
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":340
 *             if PyArray_HASFIELDS(self):
 *                 PyObject_Free(info.format)
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):             # <<<<<<<<<<<<<<
 *                 PyObject_Free(info.strides)
 *                 # info.shape was stored after info.strides in the same block
 */
  __Pyx_TraceLine(340,0,__PYX_ERR(2, 340, __pyx_L1_error))
  __pyx_t_1 = (((sizeof(npy_intp)) != (sizeof(Py_ssize_t))) != 0);
  if (__pyx_t_1) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":341
 *                 PyObject_Free(info.format)
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):
 *                 PyObject_Free(info.strides)             # <<<<<<<<<<<<<<
 *                 # info.shape was stored after info.strides in the same block
 * 
 */
    __Pyx_TraceLine(341,0,__PYX_ERR(2, 341, __pyx_L1_error))
    PyObject_Free(__pyx_v_info->strides);

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":340
 *             if PyArray_HASFIELDS(self):
 *                 PyObject_Free(info.format)
 *             if sizeof(npy_intp) != sizeof(Py_ssize_t):             # <<<<<<<<<<<<<<
 *                 PyObject_Free(info.strides)
 *                 # info.shape was stored after info.strides in the same block
 */
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":337
 *                 f[0] = c'\0' # Terminate format string
 * 
 *         def __releasebuffer__(ndarray self, Py_buffer* info):             # <<<<<<<<<<<<<<
 *             if PyArray_HASFIELDS(self):
 *                 PyObject_Free(info.format)
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("numpy.ndarray.__releasebuffer__", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":821
 * ctypedef npy_cdouble     complex_t
 * 
 * cdef inline object PyArray_MultiIterNew1(a):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(1, <void*>a)
 * 
 */

static CYTHON_INLINE PyObject *__pyx_f_5numpy_PyArray_MultiIterNew1(PyObject *__pyx_v_a) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("PyArray_MultiIterNew1", 0);
  __Pyx_TraceCall("PyArray_MultiIterNew1", __pyx_f[2], 821, 0, __PYX_ERR(2, 821, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":822
 * 
 * cdef inline object PyArray_MultiIterNew1(a):
 *     return PyArray_MultiIterNew(1, <void*>a)             # <<<<<<<<<<<<<<
 * 
 * cdef inline object PyArray_MultiIterNew2(a, b):
 */
  __Pyx_TraceLine(822,0,__PYX_ERR(2, 822, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = PyArray_MultiIterNew(1, ((void *)__pyx_v_a)); if (unlikely(!__pyx_t_1)) __PYX_ERR(2, 822, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":821
 * ctypedef npy_cdouble     complex_t
 * 
 * cdef inline object PyArray_MultiIterNew1(a):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(1, <void*>a)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("numpy.PyArray_MultiIterNew1", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":824
 *     return PyArray_MultiIterNew(1, <void*>a)
 * 
 * cdef inline object PyArray_MultiIterNew2(a, b):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(2, <void*>a, <void*>b)
 * 
 */

static CYTHON_INLINE PyObject *__pyx_f_5numpy_PyArray_MultiIterNew2(PyObject *__pyx_v_a, PyObject *__pyx_v_b) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("PyArray_MultiIterNew2", 0);
  __Pyx_TraceCall("PyArray_MultiIterNew2", __pyx_f[2], 824, 0, __PYX_ERR(2, 824, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":825
 * 
 * cdef inline object PyArray_MultiIterNew2(a, b):
 *     return PyArray_MultiIterNew(2, <void*>a, <void*>b)             # <<<<<<<<<<<<<<
 * 
 * cdef inline object PyArray_MultiIterNew3(a, b, c):
 */
  __Pyx_TraceLine(825,0,__PYX_ERR(2, 825, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = PyArray_MultiIterNew(2, ((void *)__pyx_v_a), ((void *)__pyx_v_b)); if (unlikely(!__pyx_t_1)) __PYX_ERR(2, 825, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":824
 *     return PyArray_MultiIterNew(1, <void*>a)
 * 
 * cdef inline object PyArray_MultiIterNew2(a, b):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(2, <void*>a, <void*>b)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("numpy.PyArray_MultiIterNew2", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":827
 *     return PyArray_MultiIterNew(2, <void*>a, <void*>b)
 * 
 * cdef inline object PyArray_MultiIterNew3(a, b, c):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(3, <void*>a, <void*>b, <void*> c)
 * 
 */

static CYTHON_INLINE PyObject *__pyx_f_5numpy_PyArray_MultiIterNew3(PyObject *__pyx_v_a, PyObject *__pyx_v_b, PyObject *__pyx_v_c) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("PyArray_MultiIterNew3", 0);
  __Pyx_TraceCall("PyArray_MultiIterNew3", __pyx_f[2], 827, 0, __PYX_ERR(2, 827, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":828
 * 
 * cdef inline object PyArray_MultiIterNew3(a, b, c):
 *     return PyArray_MultiIterNew(3, <void*>a, <void*>b, <void*> c)             # <<<<<<<<<<<<<<
 * 
 * cdef inline object PyArray_MultiIterNew4(a, b, c, d):
 */
  __Pyx_TraceLine(828,0,__PYX_ERR(2, 828, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = PyArray_MultiIterNew(3, ((void *)__pyx_v_a), ((void *)__pyx_v_b), ((void *)__pyx_v_c)); if (unlikely(!__pyx_t_1)) __PYX_ERR(2, 828, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":827
 *     return PyArray_MultiIterNew(2, <void*>a, <void*>b)
 * 
 * cdef inline object PyArray_MultiIterNew3(a, b, c):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(3, <void*>a, <void*>b, <void*> c)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("numpy.PyArray_MultiIterNew3", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":830
 *     return PyArray_MultiIterNew(3, <void*>a, <void*>b, <void*> c)
 * 
 * cdef inline object PyArray_MultiIterNew4(a, b, c, d):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(4, <void*>a, <void*>b, <void*>c, <void*> d)
 * 
 */

static CYTHON_INLINE PyObject *__pyx_f_5numpy_PyArray_MultiIterNew4(PyObject *__pyx_v_a, PyObject *__pyx_v_b, PyObject *__pyx_v_c, PyObject *__pyx_v_d) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("PyArray_MultiIterNew4", 0);
  __Pyx_TraceCall("PyArray_MultiIterNew4", __pyx_f[2], 830, 0, __PYX_ERR(2, 830, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":831
 * 
 * cdef inline object PyArray_MultiIterNew4(a, b, c, d):
 *     return PyArray_MultiIterNew(4, <void*>a, <void*>b, <void*>c, <void*> d)             # <<<<<<<<<<<<<<
 * 
 * cdef inline object PyArray_MultiIterNew5(a, b, c, d, e):
 */
  __Pyx_TraceLine(831,0,__PYX_ERR(2, 831, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = PyArray_MultiIterNew(4, ((void *)__pyx_v_a), ((void *)__pyx_v_b), ((void *)__pyx_v_c), ((void *)__pyx_v_d)); if (unlikely(!__pyx_t_1)) __PYX_ERR(2, 831, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":830
 *     return PyArray_MultiIterNew(3, <void*>a, <void*>b, <void*> c)
 * 
 * cdef inline object PyArray_MultiIterNew4(a, b, c, d):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(4, <void*>a, <void*>b, <void*>c, <void*> d)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("numpy.PyArray_MultiIterNew4", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":833
 *     return PyArray_MultiIterNew(4, <void*>a, <void*>b, <void*>c, <void*> d)
 * 
 * cdef inline object PyArray_MultiIterNew5(a, b, c, d, e):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(5, <void*>a, <void*>b, <void*>c, <void*> d, <void*> e)
 * 
 */

static CYTHON_INLINE PyObject *__pyx_f_5numpy_PyArray_MultiIterNew5(PyObject *__pyx_v_a, PyObject *__pyx_v_b, PyObject *__pyx_v_c, PyObject *__pyx_v_d, PyObject *__pyx_v_e) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("PyArray_MultiIterNew5", 0);
  __Pyx_TraceCall("PyArray_MultiIterNew5", __pyx_f[2], 833, 0, __PYX_ERR(2, 833, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":834
 * 
 * cdef inline object PyArray_MultiIterNew5(a, b, c, d, e):
 *     return PyArray_MultiIterNew(5, <void*>a, <void*>b, <void*>c, <void*> d, <void*> e)             # <<<<<<<<<<<<<<
 * 
 * cdef inline tuple PyDataType_SHAPE(dtype d):
 */
  __Pyx_TraceLine(834,0,__PYX_ERR(2, 834, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __pyx_t_1 = PyArray_MultiIterNew(5, ((void *)__pyx_v_a), ((void *)__pyx_v_b), ((void *)__pyx_v_c), ((void *)__pyx_v_d), ((void *)__pyx_v_e)); if (unlikely(!__pyx_t_1)) __PYX_ERR(2, 834, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_r = __pyx_t_1;
  __pyx_t_1 = 0;
  goto __pyx_L0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":833
 *     return PyArray_MultiIterNew(4, <void*>a, <void*>b, <void*>c, <void*> d)
 * 
 * cdef inline object PyArray_MultiIterNew5(a, b, c, d, e):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(5, <void*>a, <void*>b, <void*>c, <void*> d, <void*> e)
 * 
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_AddTraceback("numpy.PyArray_MultiIterNew5", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":836
 *     return PyArray_MultiIterNew(5, <void*>a, <void*>b, <void*>c, <void*> d, <void*> e)
 * 
 * cdef inline tuple PyDataType_SHAPE(dtype d):             # <<<<<<<<<<<<<<
 *     if PyDataType_HASSUBARRAY(d):
 *         return <tuple>d.subarray.shape
 */

static CYTHON_INLINE PyObject *__pyx_f_5numpy_PyDataType_SHAPE(PyArray_Descr *__pyx_v_d) {
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  __Pyx_RefNannySetupContext("PyDataType_SHAPE", 0);
  __Pyx_TraceCall("PyDataType_SHAPE", __pyx_f[2], 836, 0, __PYX_ERR(2, 836, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":837
 * 
 * cdef inline tuple PyDataType_SHAPE(dtype d):
 *     if PyDataType_HASSUBARRAY(d):             # <<<<<<<<<<<<<<
 *         return <tuple>d.subarray.shape
 *     else:
 */
  __Pyx_TraceLine(837,0,__PYX_ERR(2, 837, __pyx_L1_error))
  __pyx_t_1 = (PyDataType_HASSUBARRAY(__pyx_v_d) != 0);
  if (__pyx_t_1) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":838
 * cdef inline tuple PyDataType_SHAPE(dtype d):
 *     if PyDataType_HASSUBARRAY(d):
 *         return <tuple>d.subarray.shape             # <<<<<<<<<<<<<<
 *     else:
 *         return ()
 */
    __Pyx_TraceLine(838,0,__PYX_ERR(2, 838, __pyx_L1_error))
    __Pyx_XDECREF(__pyx_r);
    __Pyx_INCREF(((PyObject*)__pyx_v_d->subarray->shape));
    __pyx_r = ((PyObject*)__pyx_v_d->subarray->shape);
    goto __pyx_L0;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":837
 * 
 * cdef inline tuple PyDataType_SHAPE(dtype d):
 *     if PyDataType_HASSUBARRAY(d):             # <<<<<<<<<<<<<<
 *         return <tuple>d.subarray.shape
 *     else:
 */
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":840
 *         return <tuple>d.subarray.shape
 *     else:
 *         return ()             # <<<<<<<<<<<<<<
 * 
 * cdef inline char* _util_dtypestring(dtype descr, char* f, char* end, int* offset) except NULL:
 */
  __Pyx_TraceLine(840,0,__PYX_ERR(2, 840, __pyx_L1_error))
  /*else*/ {
    __Pyx_XDECREF(__pyx_r);
    __Pyx_INCREF(__pyx_empty_tuple);
    __pyx_r = __pyx_empty_tuple;
    goto __pyx_L0;
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":836
 *     return PyArray_MultiIterNew(5, <void*>a, <void*>b, <void*>c, <void*> d, <void*> e)
 * 
 * cdef inline tuple PyDataType_SHAPE(dtype d):             # <<<<<<<<<<<<<<
 *     if PyDataType_HASSUBARRAY(d):
 *         return <tuple>d.subarray.shape
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("numpy.PyDataType_SHAPE", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":842
 *         return ()
 * 
 * cdef inline char* _util_dtypestring(dtype descr, char* f, char* end, int* offset) except NULL:             # <<<<<<<<<<<<<<
 *     # Recursive utility function used in __getbuffer__ to get format
 *     # string. The new location in the format string is returned.
 */

static CYTHON_INLINE char *__pyx_f_5numpy__util_dtypestring(PyArray_Descr *__pyx_v_descr, char *__pyx_v_f, char *__pyx_v_end, int *__pyx_v_offset) {
  PyArray_Descr *__pyx_v_child = 0;
  int __pyx_v_endian_detector;
  int __pyx_v_little_endian;
  PyObject *__pyx_v_fields = 0;
  PyObject *__pyx_v_childname = NULL;
  PyObject *__pyx_v_new_offset = NULL;
  PyObject *__pyx_v_t = NULL;
  char *__pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  Py_ssize_t __pyx_t_2;
  PyObject *__pyx_t_3 = NULL;
  PyObject *__pyx_t_4 = NULL;
  int __pyx_t_5;
  int __pyx_t_6;
  int __pyx_t_7;
  long __pyx_t_8;
  char *__pyx_t_9;
  __Pyx_RefNannySetupContext("_util_dtypestring", 0);
  __Pyx_TraceCall("_util_dtypestring", __pyx_f[2], 842, 0, __PYX_ERR(2, 842, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":847
 * 
 *     cdef dtype child
 *     cdef int endian_detector = 1             # <<<<<<<<<<<<<<
 *     cdef bint little_endian = ((<char*>&endian_detector)[0] != 0)
 *     cdef tuple fields
 */
  __Pyx_TraceLine(847,0,__PYX_ERR(2, 847, __pyx_L1_error))
  __pyx_v_endian_detector = 1;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":848
 *     cdef dtype child
 *     cdef int endian_detector = 1
 *     cdef bint little_endian = ((<char*>&endian_detector)[0] != 0)             # <<<<<<<<<<<<<<
 *     cdef tuple fields
 * 
 */
  __Pyx_TraceLine(848,0,__PYX_ERR(2, 848, __pyx_L1_error))
  __pyx_v_little_endian = ((((char *)(&__pyx_v_endian_detector))[0]) != 0);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":851
 *     cdef tuple fields
 * 
 *     for childname in descr.names:             # <<<<<<<<<<<<<<
 *         fields = descr.fields[childname]
 *         child, new_offset = fields
 */
  __Pyx_TraceLine(851,0,__PYX_ERR(2, 851, __pyx_L1_error))
  if (unlikely(__pyx_v_descr->names == Py_None)) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
    __PYX_ERR(2, 851, __pyx_L1_error)
  }
  __pyx_t_1 = __pyx_v_descr->names; __Pyx_INCREF(__pyx_t_1); __pyx_t_2 = 0;
  for (;;) {
    if (__pyx_t_2 >= PyTuple_GET_SIZE(__pyx_t_1)) break;
    #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    __pyx_t_3 = PyTuple_GET_ITEM(__pyx_t_1, __pyx_t_2); __Pyx_INCREF(__pyx_t_3); __pyx_t_2++; if (unlikely(0 < 0)) __PYX_ERR(2, 851, __pyx_L1_error)
    #else
    __pyx_t_3 = PySequence_ITEM(__pyx_t_1, __pyx_t_2); __pyx_t_2++; if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 851, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    #endif
    __Pyx_XDECREF_SET(__pyx_v_childname, __pyx_t_3);
    __pyx_t_3 = 0;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":852
 * 
 *     for childname in descr.names:
 *         fields = descr.fields[childname]             # <<<<<<<<<<<<<<
 *         child, new_offset = fields
 * 
 */
    __Pyx_TraceLine(852,0,__PYX_ERR(2, 852, __pyx_L1_error))
    if (unlikely(__pyx_v_descr->fields == Py_None)) {
      PyErr_SetString(PyExc_TypeError, "'NoneType' object is not subscriptable");
      __PYX_ERR(2, 852, __pyx_L1_error)
    }
    __pyx_t_3 = __Pyx_PyDict_GetItem(__pyx_v_descr->fields, __pyx_v_childname); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 852, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    if (!(likely(PyTuple_CheckExact(__pyx_t_3))||((__pyx_t_3) == Py_None)||(PyErr_Format(PyExc_TypeError, "Expected %.16s, got %.200s", "tuple", Py_TYPE(__pyx_t_3)->tp_name), 0))) __PYX_ERR(2, 852, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_fields, ((PyObject*)__pyx_t_3));
    __pyx_t_3 = 0;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":853
 *     for childname in descr.names:
 *         fields = descr.fields[childname]
 *         child, new_offset = fields             # <<<<<<<<<<<<<<
 * 
 *         if (end - f) - <int>(new_offset - offset[0]) < 15:
 */
    __Pyx_TraceLine(853,0,__PYX_ERR(2, 853, __pyx_L1_error))
    if (likely(__pyx_v_fields != Py_None)) {
      PyObject* sequence = __pyx_v_fields;
      Py_ssize_t size = __Pyx_PySequence_SIZE(sequence);
      if (unlikely(size != 2)) {
        if (size > 2) __Pyx_RaiseTooManyValuesError(2);
        else if (size >= 0) __Pyx_RaiseNeedMoreValuesError(size);
        __PYX_ERR(2, 853, __pyx_L1_error)
      }
      #if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
      __pyx_t_3 = PyTuple_GET_ITEM(sequence, 0); 
      __pyx_t_4 = PyTuple_GET_ITEM(sequence, 1); 
      __Pyx_INCREF(__pyx_t_3);
      __Pyx_INCREF(__pyx_t_4);
      #else
      __pyx_t_3 = PySequence_ITEM(sequence, 0); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 853, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PySequence_ITEM(sequence, 1); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 853, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      #endif
    } else {
      __Pyx_RaiseNoneNotIterableError(); __PYX_ERR(2, 853, __pyx_L1_error)
    }
    if (!(likely(((__pyx_t_3) == Py_None) || likely(__Pyx_TypeTest(__pyx_t_3, __pyx_ptype_5numpy_dtype))))) __PYX_ERR(2, 853, __pyx_L1_error)
    __Pyx_XDECREF_SET(__pyx_v_child, ((PyArray_Descr *)__pyx_t_3));
    __pyx_t_3 = 0;
    __Pyx_XDECREF_SET(__pyx_v_new_offset, __pyx_t_4);
    __pyx_t_4 = 0;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":855
 *         child, new_offset = fields
 * 
 *         if (end - f) - <int>(new_offset - offset[0]) < 15:             # <<<<<<<<<<<<<<
 *             raise RuntimeError(u"Format string allocated too short, see comment in numpy.pxd")
 * 
 */
    __Pyx_TraceLine(855,0,__PYX_ERR(2, 855, __pyx_L1_error))
    __pyx_t_4 = __Pyx_PyInt_From_int((__pyx_v_offset[0])); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 855, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_4);
    __pyx_t_3 = PyNumber_Subtract(__pyx_v_new_offset, __pyx_t_4); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 855, __pyx_L1_error)
    __Pyx_GOTREF(__pyx_t_3);
    __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
    __pyx_t_5 = __Pyx_PyInt_As_int(__pyx_t_3); if (unlikely((__pyx_t_5 == (int)-1) && PyErr_Occurred())) __PYX_ERR(2, 855, __pyx_L1_error)
    __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
    __pyx_t_6 = ((((__pyx_v_end - __pyx_v_f) - ((int)__pyx_t_5)) < 15) != 0);
    if (unlikely(__pyx_t_6)) {

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":856
 * 
 *         if (end - f) - <int>(new_offset - offset[0]) < 15:
 *             raise RuntimeError(u"Format string allocated too short, see comment in numpy.pxd")             # <<<<<<<<<<<<<<
 * 
 *         if ((child.byteorder == c'>' and little_endian) or
 */
      __Pyx_TraceLine(856,0,__PYX_ERR(2, 856, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_RuntimeError, __pyx_tuple__19, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 856, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_Raise(__pyx_t_3, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __PYX_ERR(2, 856, __pyx_L1_error)

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":855
 *         child, new_offset = fields
 * 
 *         if (end - f) - <int>(new_offset - offset[0]) < 15:             # <<<<<<<<<<<<<<
 *             raise RuntimeError(u"Format string allocated too short, see comment in numpy.pxd")
 * 
 */
    }

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":858
 *             raise RuntimeError(u"Format string allocated too short, see comment in numpy.pxd")
 * 
 *         if ((child.byteorder == c'>' and little_endian) or             # <<<<<<<<<<<<<<
 *             (child.byteorder == c'<' and not little_endian)):
 *             raise ValueError(u"Non-native byte order not supported")
 */
    __Pyx_TraceLine(858,0,__PYX_ERR(2, 858, __pyx_L1_error))
    __pyx_t_7 = ((__pyx_v_child->byteorder == '>') != 0);
    if (!__pyx_t_7) {
      goto __pyx_L8_next_or;
    } else {
    }
    __pyx_t_7 = (__pyx_v_little_endian != 0);
    if (!__pyx_t_7) {
    } else {
      __pyx_t_6 = __pyx_t_7;
      goto __pyx_L7_bool_binop_done;
    }
    __pyx_L8_next_or:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":859
 * 
 *         if ((child.byteorder == c'>' and little_endian) or
 *             (child.byteorder == c'<' and not little_endian)):             # <<<<<<<<<<<<<<
 *             raise ValueError(u"Non-native byte order not supported")
 *             # One could encode it in the format string and have Cython
 */
    __Pyx_TraceLine(859,0,__PYX_ERR(2, 859, __pyx_L1_error))
    __pyx_t_7 = ((__pyx_v_child->byteorder == '<') != 0);
    if (__pyx_t_7) {
    } else {
      __pyx_t_6 = __pyx_t_7;
      goto __pyx_L7_bool_binop_done;
    }
    __pyx_t_7 = ((!(__pyx_v_little_endian != 0)) != 0);
    __pyx_t_6 = __pyx_t_7;
    __pyx_L7_bool_binop_done:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":858
 *             raise RuntimeError(u"Format string allocated too short, see comment in numpy.pxd")
 * 
 *         if ((child.byteorder == c'>' and little_endian) or             # <<<<<<<<<<<<<<
 *             (child.byteorder == c'<' and not little_endian)):
 *             raise ValueError(u"Non-native byte order not supported")
 */
    __Pyx_TraceLine(858,0,__PYX_ERR(2, 858, __pyx_L1_error))
    if (unlikely(__pyx_t_6)) {

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":860
 *         if ((child.byteorder == c'>' and little_endian) or
 *             (child.byteorder == c'<' and not little_endian)):
 *             raise ValueError(u"Non-native byte order not supported")             # <<<<<<<<<<<<<<
 *             # One could encode it in the format string and have Cython
 *             # complain instead, BUT: < and > in format strings also imply
 */
      __Pyx_TraceLine(860,0,__PYX_ERR(2, 860, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyObject_Call(__pyx_builtin_ValueError, __pyx_tuple__18, NULL); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 860, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __Pyx_Raise(__pyx_t_3, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __PYX_ERR(2, 860, __pyx_L1_error)

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":858
 *             raise RuntimeError(u"Format string allocated too short, see comment in numpy.pxd")
 * 
 *         if ((child.byteorder == c'>' and little_endian) or             # <<<<<<<<<<<<<<
 *             (child.byteorder == c'<' and not little_endian)):
 *             raise ValueError(u"Non-native byte order not supported")
 */
    }

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":870
 * 
 *         # Output padding bytes
 *         while offset[0] < new_offset:             # <<<<<<<<<<<<<<
 *             f[0] = 120 # "x"; pad byte
 *             f += 1
 */
    __Pyx_TraceLine(870,0,__PYX_ERR(2, 870, __pyx_L1_error))
    while (1) {
      __pyx_t_3 = __Pyx_PyInt_From_int((__pyx_v_offset[0])); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 870, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_t_3, __pyx_v_new_offset, Py_LT); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 870, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 870, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (!__pyx_t_6) break;

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":871
 *         # Output padding bytes
 *         while offset[0] < new_offset:
 *             f[0] = 120 # "x"; pad byte             # <<<<<<<<<<<<<<
 *             f += 1
 *             offset[0] += 1
 */
      __Pyx_TraceLine(871,0,__PYX_ERR(2, 871, __pyx_L1_error))
      (__pyx_v_f[0]) = 0x78;

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":872
 *         while offset[0] < new_offset:
 *             f[0] = 120 # "x"; pad byte
 *             f += 1             # <<<<<<<<<<<<<<
 *             offset[0] += 1
 * 
 */
      __Pyx_TraceLine(872,0,__PYX_ERR(2, 872, __pyx_L1_error))
      __pyx_v_f = (__pyx_v_f + 1);

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":873
 *             f[0] = 120 # "x"; pad byte
 *             f += 1
 *             offset[0] += 1             # <<<<<<<<<<<<<<
 * 
 *         offset[0] += child.itemsize
 */
      __Pyx_TraceLine(873,0,__PYX_ERR(2, 873, __pyx_L1_error))
      __pyx_t_8 = 0;
      (__pyx_v_offset[__pyx_t_8]) = ((__pyx_v_offset[__pyx_t_8]) + 1);
    }

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":875
 *             offset[0] += 1
 * 
 *         offset[0] += child.itemsize             # <<<<<<<<<<<<<<
 * 
 *         if not PyDataType_HASFIELDS(child):
 */
    __Pyx_TraceLine(875,0,__PYX_ERR(2, 875, __pyx_L1_error))
    __pyx_t_8 = 0;
    (__pyx_v_offset[__pyx_t_8]) = ((__pyx_v_offset[__pyx_t_8]) + __pyx_v_child->elsize);

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":877
 *         offset[0] += child.itemsize
 * 
 *         if not PyDataType_HASFIELDS(child):             # <<<<<<<<<<<<<<
 *             t = child.type_num
 *             if end - f < 5:
 */
    __Pyx_TraceLine(877,0,__PYX_ERR(2, 877, __pyx_L1_error))
    __pyx_t_6 = ((!(PyDataType_HASFIELDS(__pyx_v_child) != 0)) != 0);
    if (__pyx_t_6) {

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":878
 * 
 *         if not PyDataType_HASFIELDS(child):
 *             t = child.type_num             # <<<<<<<<<<<<<<
 *             if end - f < 5:
 *                 raise RuntimeError(u"Format string allocated too short.")
 */
      __Pyx_TraceLine(878,0,__PYX_ERR(2, 878, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_int(__pyx_v_child->type_num); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 878, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __Pyx_XDECREF_SET(__pyx_v_t, __pyx_t_4);
      __pyx_t_4 = 0;

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":879
 *         if not PyDataType_HASFIELDS(child):
 *             t = child.type_num
 *             if end - f < 5:             # <<<<<<<<<<<<<<
 *                 raise RuntimeError(u"Format string allocated too short.")
 * 
 */
      __Pyx_TraceLine(879,0,__PYX_ERR(2, 879, __pyx_L1_error))
      __pyx_t_6 = (((__pyx_v_end - __pyx_v_f) < 5) != 0);
      if (unlikely(__pyx_t_6)) {

        /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":880
 *             t = child.type_num
 *             if end - f < 5:
 *                 raise RuntimeError(u"Format string allocated too short.")             # <<<<<<<<<<<<<<
 * 
 *             # Until ticket #99 is fixed, use integers to avoid warnings
 */
        __Pyx_TraceLine(880,0,__PYX_ERR(2, 880, __pyx_L1_error))
        __pyx_t_4 = __Pyx_PyObject_Call(__pyx_builtin_RuntimeError, __pyx_tuple__20, NULL); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 880, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __Pyx_Raise(__pyx_t_4, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        __PYX_ERR(2, 880, __pyx_L1_error)

        /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":879
 *         if not PyDataType_HASFIELDS(child):
 *             t = child.type_num
 *             if end - f < 5:             # <<<<<<<<<<<<<<
 *                 raise RuntimeError(u"Format string allocated too short.")
 * 
 */
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":883
 * 
 *             # Until ticket #99 is fixed, use integers to avoid warnings
 *             if   t == NPY_BYTE:        f[0] =  98 #"b"             # <<<<<<<<<<<<<<
 *             elif t == NPY_UBYTE:       f[0] =  66 #"B"
 *             elif t == NPY_SHORT:       f[0] = 104 #"h"
 */
      __Pyx_TraceLine(883,0,__PYX_ERR(2, 883, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_BYTE); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 883, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 883, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 883, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 98;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":884
 *             # Until ticket #99 is fixed, use integers to avoid warnings
 *             if   t == NPY_BYTE:        f[0] =  98 #"b"
 *             elif t == NPY_UBYTE:       f[0] =  66 #"B"             # <<<<<<<<<<<<<<
 *             elif t == NPY_SHORT:       f[0] = 104 #"h"
 *             elif t == NPY_USHORT:      f[0] =  72 #"H"
 */
      __Pyx_TraceLine(884,0,__PYX_ERR(2, 884, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_UBYTE); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 884, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 884, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 884, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 66;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":885
 *             if   t == NPY_BYTE:        f[0] =  98 #"b"
 *             elif t == NPY_UBYTE:       f[0] =  66 #"B"
 *             elif t == NPY_SHORT:       f[0] = 104 #"h"             # <<<<<<<<<<<<<<
 *             elif t == NPY_USHORT:      f[0] =  72 #"H"
 *             elif t == NPY_INT:         f[0] = 105 #"i"
 */
      __Pyx_TraceLine(885,0,__PYX_ERR(2, 885, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_SHORT); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 885, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 885, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 885, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 0x68;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":886
 *             elif t == NPY_UBYTE:       f[0] =  66 #"B"
 *             elif t == NPY_SHORT:       f[0] = 104 #"h"
 *             elif t == NPY_USHORT:      f[0] =  72 #"H"             # <<<<<<<<<<<<<<
 *             elif t == NPY_INT:         f[0] = 105 #"i"
 *             elif t == NPY_UINT:        f[0] =  73 #"I"
 */
      __Pyx_TraceLine(886,0,__PYX_ERR(2, 886, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_USHORT); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 886, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 886, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 886, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 72;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":887
 *             elif t == NPY_SHORT:       f[0] = 104 #"h"
 *             elif t == NPY_USHORT:      f[0] =  72 #"H"
 *             elif t == NPY_INT:         f[0] = 105 #"i"             # <<<<<<<<<<<<<<
 *             elif t == NPY_UINT:        f[0] =  73 #"I"
 *             elif t == NPY_LONG:        f[0] = 108 #"l"
 */
      __Pyx_TraceLine(887,0,__PYX_ERR(2, 887, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_INT); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 887, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 887, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 887, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 0x69;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":888
 *             elif t == NPY_USHORT:      f[0] =  72 #"H"
 *             elif t == NPY_INT:         f[0] = 105 #"i"
 *             elif t == NPY_UINT:        f[0] =  73 #"I"             # <<<<<<<<<<<<<<
 *             elif t == NPY_LONG:        f[0] = 108 #"l"
 *             elif t == NPY_ULONG:       f[0] = 76  #"L"
 */
      __Pyx_TraceLine(888,0,__PYX_ERR(2, 888, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_UINT); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 888, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 888, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 888, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 73;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":889
 *             elif t == NPY_INT:         f[0] = 105 #"i"
 *             elif t == NPY_UINT:        f[0] =  73 #"I"
 *             elif t == NPY_LONG:        f[0] = 108 #"l"             # <<<<<<<<<<<<<<
 *             elif t == NPY_ULONG:       f[0] = 76  #"L"
 *             elif t == NPY_LONGLONG:    f[0] = 113 #"q"
 */
      __Pyx_TraceLine(889,0,__PYX_ERR(2, 889, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_LONG); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 889, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 889, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 889, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 0x6C;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":890
 *             elif t == NPY_UINT:        f[0] =  73 #"I"
 *             elif t == NPY_LONG:        f[0] = 108 #"l"
 *             elif t == NPY_ULONG:       f[0] = 76  #"L"             # <<<<<<<<<<<<<<
 *             elif t == NPY_LONGLONG:    f[0] = 113 #"q"
 *             elif t == NPY_ULONGLONG:   f[0] = 81  #"Q"
 */
      __Pyx_TraceLine(890,0,__PYX_ERR(2, 890, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_ULONG); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 890, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 890, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 890, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 76;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":891
 *             elif t == NPY_LONG:        f[0] = 108 #"l"
 *             elif t == NPY_ULONG:       f[0] = 76  #"L"
 *             elif t == NPY_LONGLONG:    f[0] = 113 #"q"             # <<<<<<<<<<<<<<
 *             elif t == NPY_ULONGLONG:   f[0] = 81  #"Q"
 *             elif t == NPY_FLOAT:       f[0] = 102 #"f"
 */
      __Pyx_TraceLine(891,0,__PYX_ERR(2, 891, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_LONGLONG); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 891, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 891, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 891, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 0x71;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":892
 *             elif t == NPY_ULONG:       f[0] = 76  #"L"
 *             elif t == NPY_LONGLONG:    f[0] = 113 #"q"
 *             elif t == NPY_ULONGLONG:   f[0] = 81  #"Q"             # <<<<<<<<<<<<<<
 *             elif t == NPY_FLOAT:       f[0] = 102 #"f"
 *             elif t == NPY_DOUBLE:      f[0] = 100 #"d"
 */
      __Pyx_TraceLine(892,0,__PYX_ERR(2, 892, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_ULONGLONG); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 892, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 892, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 892, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 81;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":893
 *             elif t == NPY_LONGLONG:    f[0] = 113 #"q"
 *             elif t == NPY_ULONGLONG:   f[0] = 81  #"Q"
 *             elif t == NPY_FLOAT:       f[0] = 102 #"f"             # <<<<<<<<<<<<<<
 *             elif t == NPY_DOUBLE:      f[0] = 100 #"d"
 *             elif t == NPY_LONGDOUBLE:  f[0] = 103 #"g"
 */
      __Pyx_TraceLine(893,0,__PYX_ERR(2, 893, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_FLOAT); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 893, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 893, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 893, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 0x66;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":894
 *             elif t == NPY_ULONGLONG:   f[0] = 81  #"Q"
 *             elif t == NPY_FLOAT:       f[0] = 102 #"f"
 *             elif t == NPY_DOUBLE:      f[0] = 100 #"d"             # <<<<<<<<<<<<<<
 *             elif t == NPY_LONGDOUBLE:  f[0] = 103 #"g"
 *             elif t == NPY_CFLOAT:      f[0] = 90; f[1] = 102; f += 1 # Zf
 */
      __Pyx_TraceLine(894,0,__PYX_ERR(2, 894, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_DOUBLE); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 894, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 894, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 894, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 0x64;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":895
 *             elif t == NPY_FLOAT:       f[0] = 102 #"f"
 *             elif t == NPY_DOUBLE:      f[0] = 100 #"d"
 *             elif t == NPY_LONGDOUBLE:  f[0] = 103 #"g"             # <<<<<<<<<<<<<<
 *             elif t == NPY_CFLOAT:      f[0] = 90; f[1] = 102; f += 1 # Zf
 *             elif t == NPY_CDOUBLE:     f[0] = 90; f[1] = 100; f += 1 # Zd
 */
      __Pyx_TraceLine(895,0,__PYX_ERR(2, 895, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_LONGDOUBLE); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 895, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 895, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 895, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 0x67;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":896
 *             elif t == NPY_DOUBLE:      f[0] = 100 #"d"
 *             elif t == NPY_LONGDOUBLE:  f[0] = 103 #"g"
 *             elif t == NPY_CFLOAT:      f[0] = 90; f[1] = 102; f += 1 # Zf             # <<<<<<<<<<<<<<
 *             elif t == NPY_CDOUBLE:     f[0] = 90; f[1] = 100; f += 1 # Zd
 *             elif t == NPY_CLONGDOUBLE: f[0] = 90; f[1] = 103; f += 1 # Zg
 */
      __Pyx_TraceLine(896,0,__PYX_ERR(2, 896, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_CFLOAT); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 896, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 896, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 896, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 90;
        (__pyx_v_f[1]) = 0x66;
        __pyx_v_f = (__pyx_v_f + 1);
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":897
 *             elif t == NPY_LONGDOUBLE:  f[0] = 103 #"g"
 *             elif t == NPY_CFLOAT:      f[0] = 90; f[1] = 102; f += 1 # Zf
 *             elif t == NPY_CDOUBLE:     f[0] = 90; f[1] = 100; f += 1 # Zd             # <<<<<<<<<<<<<<
 *             elif t == NPY_CLONGDOUBLE: f[0] = 90; f[1] = 103; f += 1 # Zg
 *             elif t == NPY_OBJECT:      f[0] = 79 #"O"
 */
      __Pyx_TraceLine(897,0,__PYX_ERR(2, 897, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_CDOUBLE); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 897, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 897, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 897, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 90;
        (__pyx_v_f[1]) = 0x64;
        __pyx_v_f = (__pyx_v_f + 1);
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":898
 *             elif t == NPY_CFLOAT:      f[0] = 90; f[1] = 102; f += 1 # Zf
 *             elif t == NPY_CDOUBLE:     f[0] = 90; f[1] = 100; f += 1 # Zd
 *             elif t == NPY_CLONGDOUBLE: f[0] = 90; f[1] = 103; f += 1 # Zg             # <<<<<<<<<<<<<<
 *             elif t == NPY_OBJECT:      f[0] = 79 #"O"
 *             else:
 */
      __Pyx_TraceLine(898,0,__PYX_ERR(2, 898, __pyx_L1_error))
      __pyx_t_3 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_CLONGDOUBLE); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 898, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_3);
      __pyx_t_4 = PyObject_RichCompare(__pyx_v_t, __pyx_t_3, Py_EQ); __Pyx_XGOTREF(__pyx_t_4); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 898, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_4); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 898, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      if (__pyx_t_6) {
        (__pyx_v_f[0]) = 90;
        (__pyx_v_f[1]) = 0x67;
        __pyx_v_f = (__pyx_v_f + 1);
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":899
 *             elif t == NPY_CDOUBLE:     f[0] = 90; f[1] = 100; f += 1 # Zd
 *             elif t == NPY_CLONGDOUBLE: f[0] = 90; f[1] = 103; f += 1 # Zg
 *             elif t == NPY_OBJECT:      f[0] = 79 #"O"             # <<<<<<<<<<<<<<
 *             else:
 *                 raise ValueError(u"unknown dtype code in numpy.pxd (%d)" % t)
 */
      __Pyx_TraceLine(899,0,__PYX_ERR(2, 899, __pyx_L1_error))
      __pyx_t_4 = __Pyx_PyInt_From_enum__NPY_TYPES(NPY_OBJECT); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 899, __pyx_L1_error)
      __Pyx_GOTREF(__pyx_t_4);
      __pyx_t_3 = PyObject_RichCompare(__pyx_v_t, __pyx_t_4, Py_EQ); __Pyx_XGOTREF(__pyx_t_3); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 899, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
      __pyx_t_6 = __Pyx_PyObject_IsTrue(__pyx_t_3); if (unlikely(__pyx_t_6 < 0)) __PYX_ERR(2, 899, __pyx_L1_error)
      __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
      if (likely(__pyx_t_6)) {
        (__pyx_v_f[0]) = 79;
        goto __pyx_L15;
      }

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":901
 *             elif t == NPY_OBJECT:      f[0] = 79 #"O"
 *             else:
 *                 raise ValueError(u"unknown dtype code in numpy.pxd (%d)" % t)             # <<<<<<<<<<<<<<
 *             f += 1
 *         else:
 */
      __Pyx_TraceLine(901,0,__PYX_ERR(2, 901, __pyx_L1_error))
      /*else*/ {
        __pyx_t_3 = __Pyx_PyUnicode_FormatSafe(__pyx_kp_u_unknown_dtype_code_in_numpy_pxd, __pyx_v_t); if (unlikely(!__pyx_t_3)) __PYX_ERR(2, 901, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_3);
        __pyx_t_4 = __Pyx_PyObject_CallOneArg(__pyx_builtin_ValueError, __pyx_t_3); if (unlikely(!__pyx_t_4)) __PYX_ERR(2, 901, __pyx_L1_error)
        __Pyx_GOTREF(__pyx_t_4);
        __Pyx_DECREF(__pyx_t_3); __pyx_t_3 = 0;
        __Pyx_Raise(__pyx_t_4, 0, 0, 0);
        __Pyx_DECREF(__pyx_t_4); __pyx_t_4 = 0;
        __PYX_ERR(2, 901, __pyx_L1_error)
      }
      __pyx_L15:;

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":902
 *             else:
 *                 raise ValueError(u"unknown dtype code in numpy.pxd (%d)" % t)
 *             f += 1             # <<<<<<<<<<<<<<
 *         else:
 *             # Cython ignores struct boundary information ("T{...}"),
 */
      __Pyx_TraceLine(902,0,__PYX_ERR(2, 902, __pyx_L1_error))
      __pyx_v_f = (__pyx_v_f + 1);

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":877
 *         offset[0] += child.itemsize
 * 
 *         if not PyDataType_HASFIELDS(child):             # <<<<<<<<<<<<<<
 *             t = child.type_num
 *             if end - f < 5:
 */
      goto __pyx_L13;
    }

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":906
 *             # Cython ignores struct boundary information ("T{...}"),
 *             # so don't output it
 *             f = _util_dtypestring(child, f, end, offset)             # <<<<<<<<<<<<<<
 *     return f
 * 
 */
    __Pyx_TraceLine(906,0,__PYX_ERR(2, 906, __pyx_L1_error))
    /*else*/ {
      __pyx_t_9 = __pyx_f_5numpy__util_dtypestring(__pyx_v_child, __pyx_v_f, __pyx_v_end, __pyx_v_offset); if (unlikely(__pyx_t_9 == ((char *)NULL))) __PYX_ERR(2, 906, __pyx_L1_error)
      __pyx_v_f = __pyx_t_9;
    }
    __pyx_L13:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":851
 *     cdef tuple fields
 * 
 *     for childname in descr.names:             # <<<<<<<<<<<<<<
 *         fields = descr.fields[childname]
 *         child, new_offset = fields
 */
    __Pyx_TraceLine(851,0,__PYX_ERR(2, 851, __pyx_L1_error))
  }
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":907
 *             # so don't output it
 *             f = _util_dtypestring(child, f, end, offset)
 *     return f             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __Pyx_TraceLine(907,0,__PYX_ERR(2, 907, __pyx_L1_error))
  __pyx_r = __pyx_v_f;
  goto __pyx_L0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":842
 *         return ()
 * 
 * cdef inline char* _util_dtypestring(dtype descr, char* f, char* end, int* offset) except NULL:             # <<<<<<<<<<<<<<
 *     # Recursive utility function used in __getbuffer__ to get format
 *     # string. The new location in the format string is returned.
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_3);
  __Pyx_XDECREF(__pyx_t_4);
  __Pyx_AddTraceback("numpy._util_dtypestring", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = NULL;
  __pyx_L0:;
  __Pyx_XDECREF((PyObject *)__pyx_v_child);
  __Pyx_XDECREF(__pyx_v_fields);
  __Pyx_XDECREF(__pyx_v_childname);
  __Pyx_XDECREF(__pyx_v_new_offset);
  __Pyx_XDECREF(__pyx_v_t);
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1022
 *     int _import_umath() except -1
 * 
 * cdef inline void set_array_base(ndarray arr, object base):             # <<<<<<<<<<<<<<
 *     Py_INCREF(base) # important to do this before stealing the reference below!
 *     PyArray_SetBaseObject(arr, base)
 */

static CYTHON_INLINE void __pyx_f_5numpy_set_array_base(PyArrayObject *__pyx_v_arr, PyObject *__pyx_v_base) {
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("set_array_base", 0);
  __Pyx_TraceCall("set_array_base", __pyx_f[2], 1022, 0, __PYX_ERR(2, 1022, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1023
 * 
 * cdef inline void set_array_base(ndarray arr, object base):
 *     Py_INCREF(base) # important to do this before stealing the reference below!             # <<<<<<<<<<<<<<
 *     PyArray_SetBaseObject(arr, base)
 * 
 */
  __Pyx_TraceLine(1023,0,__PYX_ERR(2, 1023, __pyx_L1_error))
  Py_INCREF(__pyx_v_base);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1024
 * cdef inline void set_array_base(ndarray arr, object base):
 *     Py_INCREF(base) # important to do this before stealing the reference below!
 *     PyArray_SetBaseObject(arr, base)             # <<<<<<<<<<<<<<
 * 
 * cdef inline object get_array_base(ndarray arr):
 */
  __Pyx_TraceLine(1024,0,__PYX_ERR(2, 1024, __pyx_L1_error))
  (void)(PyArray_SetBaseObject(__pyx_v_arr, __pyx_v_base));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1022
 *     int _import_umath() except -1
 * 
 * cdef inline void set_array_base(ndarray arr, object base):             # <<<<<<<<<<<<<<
 *     Py_INCREF(base) # important to do this before stealing the reference below!
 *     PyArray_SetBaseObject(arr, base)
 */

  /* function exit code */
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_WriteUnraisable("numpy.set_array_base", __pyx_clineno, __pyx_lineno, __pyx_filename, 1, 0);
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1026
 *     PyArray_SetBaseObject(arr, base)
 * 
 * cdef inline object get_array_base(ndarray arr):             # <<<<<<<<<<<<<<
 *     base = PyArray_BASE(arr)
 *     if base is NULL:
 */

static CYTHON_INLINE PyObject *__pyx_f_5numpy_get_array_base(PyArrayObject *__pyx_v_arr) {
  PyObject *__pyx_v_base;
  PyObject *__pyx_r = NULL;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  int __pyx_t_1;
  __Pyx_RefNannySetupContext("get_array_base", 0);
  __Pyx_TraceCall("get_array_base", __pyx_f[2], 1026, 0, __PYX_ERR(2, 1026, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1027
 * 
 * cdef inline object get_array_base(ndarray arr):
 *     base = PyArray_BASE(arr)             # <<<<<<<<<<<<<<
 *     if base is NULL:
 *         return None
 */
  __Pyx_TraceLine(1027,0,__PYX_ERR(2, 1027, __pyx_L1_error))
  __pyx_v_base = PyArray_BASE(__pyx_v_arr);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1028
 * cdef inline object get_array_base(ndarray arr):
 *     base = PyArray_BASE(arr)
 *     if base is NULL:             # <<<<<<<<<<<<<<
 *         return None
 *     return <object>base
 */
  __Pyx_TraceLine(1028,0,__PYX_ERR(2, 1028, __pyx_L1_error))
  __pyx_t_1 = ((__pyx_v_base == NULL) != 0);
  if (__pyx_t_1) {

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1029
 *     base = PyArray_BASE(arr)
 *     if base is NULL:
 *         return None             # <<<<<<<<<<<<<<
 *     return <object>base
 * 
 */
    __Pyx_TraceLine(1029,0,__PYX_ERR(2, 1029, __pyx_L1_error))
    __Pyx_XDECREF(__pyx_r);
    __pyx_r = Py_None; __Pyx_INCREF(Py_None);
    goto __pyx_L0;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1028
 * cdef inline object get_array_base(ndarray arr):
 *     base = PyArray_BASE(arr)
 *     if base is NULL:             # <<<<<<<<<<<<<<
 *         return None
 *     return <object>base
 */
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1030
 *     if base is NULL:
 *         return None
 *     return <object>base             # <<<<<<<<<<<<<<
 * 
 * # Versions of the import_* functions which are more suitable for
 */
  __Pyx_TraceLine(1030,0,__PYX_ERR(2, 1030, __pyx_L1_error))
  __Pyx_XDECREF(__pyx_r);
  __Pyx_INCREF(((PyObject *)__pyx_v_base));
  __pyx_r = ((PyObject *)__pyx_v_base);
  goto __pyx_L0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1026
 *     PyArray_SetBaseObject(arr, base)
 * 
 * cdef inline object get_array_base(ndarray arr):             # <<<<<<<<<<<<<<
 *     base = PyArray_BASE(arr)
 *     if base is NULL:
 */

  /* function exit code */
  __pyx_L1_error:;
  __Pyx_AddTraceback("numpy.get_array_base", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = 0;
  __pyx_L0:;
  __Pyx_XGIVEREF(__pyx_r);
  __Pyx_TraceReturn(__pyx_r, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1034
 * # Versions of the import_* functions which are more suitable for
 * # Cython code.
 * cdef inline int import_array() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_array()
 */

static CYTHON_INLINE int __pyx_f_5numpy_import_array(void) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  __Pyx_RefNannySetupContext("import_array", 0);
  __Pyx_TraceCall("import_array", __pyx_f[2], 1034, 0, __PYX_ERR(2, 1034, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1035
 * # Cython code.
 * cdef inline int import_array() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_array()
 *     except Exception:
 */
  __Pyx_TraceLine(1035,0,__PYX_ERR(2, 1035, __pyx_L1_error))
  {
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ExceptionSave(&__pyx_t_1, &__pyx_t_2, &__pyx_t_3);
    __Pyx_XGOTREF(__pyx_t_1);
    __Pyx_XGOTREF(__pyx_t_2);
    __Pyx_XGOTREF(__pyx_t_3);
    /*try:*/ {

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1036
 * cdef inline int import_array() except -1:
 *     try:
 *         _import_array()             # <<<<<<<<<<<<<<
 *     except Exception:
 *         raise ImportError("numpy.core.multiarray failed to import")
 */
      __Pyx_TraceLine(1036,0,__PYX_ERR(2, 1036, __pyx_L3_error))
      __pyx_t_4 = _import_array(); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(2, 1036, __pyx_L3_error)

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1035
 * # Cython code.
 * cdef inline int import_array() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_array()
 *     except Exception:
 */
    }
    __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    goto __pyx_L8_try_end;
    __pyx_L3_error:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1037
 *     try:
 *         _import_array()
 *     except Exception:             # <<<<<<<<<<<<<<
 *         raise ImportError("numpy.core.multiarray failed to import")
 * 
 */
    __Pyx_TraceLine(1037,0,__PYX_ERR(2, 1037, __pyx_L5_except_error))
    __pyx_t_4 = __Pyx_PyErr_ExceptionMatches(((PyObject *)(&((PyTypeObject*)PyExc_Exception)[0])));
    if (__pyx_t_4) {
      __Pyx_AddTraceback("numpy.import_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
      if (__Pyx_GetException(&__pyx_t_5, &__pyx_t_6, &__pyx_t_7) < 0) __PYX_ERR(2, 1037, __pyx_L5_except_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_GOTREF(__pyx_t_6);
      __Pyx_GOTREF(__pyx_t_7);

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1038
 *         _import_array()
 *     except Exception:
 *         raise ImportError("numpy.core.multiarray failed to import")             # <<<<<<<<<<<<<<
 * 
 * cdef inline int import_umath() except -1:
 */
      __Pyx_TraceLine(1038,0,__PYX_ERR(2, 1038, __pyx_L5_except_error))
      __pyx_t_8 = __Pyx_PyObject_Call(__pyx_builtin_ImportError, __pyx_tuple__21, NULL); if (unlikely(!__pyx_t_8)) __PYX_ERR(2, 1038, __pyx_L5_except_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_Raise(__pyx_t_8, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __PYX_ERR(2, 1038, __pyx_L5_except_error)
    }
    goto __pyx_L5_except_error;
    __pyx_L5_except_error:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1035
 * # Cython code.
 * cdef inline int import_array() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_array()
 *     except Exception:
 */
    __Pyx_XGIVEREF(__pyx_t_1);
    __Pyx_XGIVEREF(__pyx_t_2);
    __Pyx_XGIVEREF(__pyx_t_3);
    __Pyx_ExceptionReset(__pyx_t_1, __pyx_t_2, __pyx_t_3);
    goto __pyx_L1_error;
    __pyx_L8_try_end:;
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1034
 * # Versions of the import_* functions which are more suitable for
 * # Cython code.
 * cdef inline int import_array() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_array()
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_AddTraceback("numpy.import_array", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1040
 *         raise ImportError("numpy.core.multiarray failed to import")
 * 
 * cdef inline int import_umath() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_umath()
 */

static CYTHON_INLINE int __pyx_f_5numpy_import_umath(void) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  __Pyx_RefNannySetupContext("import_umath", 0);
  __Pyx_TraceCall("import_umath", __pyx_f[2], 1040, 0, __PYX_ERR(2, 1040, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1041
 * 
 * cdef inline int import_umath() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_umath()
 *     except Exception:
 */
  __Pyx_TraceLine(1041,0,__PYX_ERR(2, 1041, __pyx_L1_error))
  {
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ExceptionSave(&__pyx_t_1, &__pyx_t_2, &__pyx_t_3);
    __Pyx_XGOTREF(__pyx_t_1);
    __Pyx_XGOTREF(__pyx_t_2);
    __Pyx_XGOTREF(__pyx_t_3);
    /*try:*/ {

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1042
 * cdef inline int import_umath() except -1:
 *     try:
 *         _import_umath()             # <<<<<<<<<<<<<<
 *     except Exception:
 *         raise ImportError("numpy.core.umath failed to import")
 */
      __Pyx_TraceLine(1042,0,__PYX_ERR(2, 1042, __pyx_L3_error))
      __pyx_t_4 = _import_umath(); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(2, 1042, __pyx_L3_error)

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1041
 * 
 * cdef inline int import_umath() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_umath()
 *     except Exception:
 */
    }
    __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    goto __pyx_L8_try_end;
    __pyx_L3_error:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1043
 *     try:
 *         _import_umath()
 *     except Exception:             # <<<<<<<<<<<<<<
 *         raise ImportError("numpy.core.umath failed to import")
 * 
 */
    __Pyx_TraceLine(1043,0,__PYX_ERR(2, 1043, __pyx_L5_except_error))
    __pyx_t_4 = __Pyx_PyErr_ExceptionMatches(((PyObject *)(&((PyTypeObject*)PyExc_Exception)[0])));
    if (__pyx_t_4) {
      __Pyx_AddTraceback("numpy.import_umath", __pyx_clineno, __pyx_lineno, __pyx_filename);
      if (__Pyx_GetException(&__pyx_t_5, &__pyx_t_6, &__pyx_t_7) < 0) __PYX_ERR(2, 1043, __pyx_L5_except_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_GOTREF(__pyx_t_6);
      __Pyx_GOTREF(__pyx_t_7);

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1044
 *         _import_umath()
 *     except Exception:
 *         raise ImportError("numpy.core.umath failed to import")             # <<<<<<<<<<<<<<
 * 
 * cdef inline int import_ufunc() except -1:
 */
      __Pyx_TraceLine(1044,0,__PYX_ERR(2, 1044, __pyx_L5_except_error))
      __pyx_t_8 = __Pyx_PyObject_Call(__pyx_builtin_ImportError, __pyx_tuple__22, NULL); if (unlikely(!__pyx_t_8)) __PYX_ERR(2, 1044, __pyx_L5_except_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_Raise(__pyx_t_8, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __PYX_ERR(2, 1044, __pyx_L5_except_error)
    }
    goto __pyx_L5_except_error;
    __pyx_L5_except_error:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1041
 * 
 * cdef inline int import_umath() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_umath()
 *     except Exception:
 */
    __Pyx_XGIVEREF(__pyx_t_1);
    __Pyx_XGIVEREF(__pyx_t_2);
    __Pyx_XGIVEREF(__pyx_t_3);
    __Pyx_ExceptionReset(__pyx_t_1, __pyx_t_2, __pyx_t_3);
    goto __pyx_L1_error;
    __pyx_L8_try_end:;
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1040
 *         raise ImportError("numpy.core.multiarray failed to import")
 * 
 * cdef inline int import_umath() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_umath()
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_AddTraceback("numpy.import_umath", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}

/* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1046
 *         raise ImportError("numpy.core.umath failed to import")
 * 
 * cdef inline int import_ufunc() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_umath()
 */

static CYTHON_INLINE int __pyx_f_5numpy_import_ufunc(void) {
  int __pyx_r;
  __Pyx_TraceDeclarations
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  PyObject *__pyx_t_3 = NULL;
  int __pyx_t_4;
  PyObject *__pyx_t_5 = NULL;
  PyObject *__pyx_t_6 = NULL;
  PyObject *__pyx_t_7 = NULL;
  PyObject *__pyx_t_8 = NULL;
  __Pyx_RefNannySetupContext("import_ufunc", 0);
  __Pyx_TraceCall("import_ufunc", __pyx_f[2], 1046, 0, __PYX_ERR(2, 1046, __pyx_L1_error));

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1047
 * 
 * cdef inline int import_ufunc() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_umath()
 *     except Exception:
 */
  __Pyx_TraceLine(1047,0,__PYX_ERR(2, 1047, __pyx_L1_error))
  {
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ExceptionSave(&__pyx_t_1, &__pyx_t_2, &__pyx_t_3);
    __Pyx_XGOTREF(__pyx_t_1);
    __Pyx_XGOTREF(__pyx_t_2);
    __Pyx_XGOTREF(__pyx_t_3);
    /*try:*/ {

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1048
 * cdef inline int import_ufunc() except -1:
 *     try:
 *         _import_umath()             # <<<<<<<<<<<<<<
 *     except Exception:
 *         raise ImportError("numpy.core.umath failed to import")
 */
      __Pyx_TraceLine(1048,0,__PYX_ERR(2, 1048, __pyx_L3_error))
      __pyx_t_4 = _import_umath(); if (unlikely(__pyx_t_4 == ((int)-1))) __PYX_ERR(2, 1048, __pyx_L3_error)

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1047
 * 
 * cdef inline int import_ufunc() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_umath()
 *     except Exception:
 */
    }
    __Pyx_XDECREF(__pyx_t_1); __pyx_t_1 = 0;
    __Pyx_XDECREF(__pyx_t_2); __pyx_t_2 = 0;
    __Pyx_XDECREF(__pyx_t_3); __pyx_t_3 = 0;
    goto __pyx_L8_try_end;
    __pyx_L3_error:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1049
 *     try:
 *         _import_umath()
 *     except Exception:             # <<<<<<<<<<<<<<
 *         raise ImportError("numpy.core.umath failed to import")
 */
    __Pyx_TraceLine(1049,0,__PYX_ERR(2, 1049, __pyx_L5_except_error))
    __pyx_t_4 = __Pyx_PyErr_ExceptionMatches(((PyObject *)(&((PyTypeObject*)PyExc_Exception)[0])));
    if (__pyx_t_4) {
      __Pyx_AddTraceback("numpy.import_ufunc", __pyx_clineno, __pyx_lineno, __pyx_filename);
      if (__Pyx_GetException(&__pyx_t_5, &__pyx_t_6, &__pyx_t_7) < 0) __PYX_ERR(2, 1049, __pyx_L5_except_error)
      __Pyx_GOTREF(__pyx_t_5);
      __Pyx_GOTREF(__pyx_t_6);
      __Pyx_GOTREF(__pyx_t_7);

      /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1050
 *         _import_umath()
 *     except Exception:
 *         raise ImportError("numpy.core.umath failed to import")             # <<<<<<<<<<<<<<
 */
      __Pyx_TraceLine(1050,0,__PYX_ERR(2, 1050, __pyx_L5_except_error))
      __pyx_t_8 = __Pyx_PyObject_Call(__pyx_builtin_ImportError, __pyx_tuple__22, NULL); if (unlikely(!__pyx_t_8)) __PYX_ERR(2, 1050, __pyx_L5_except_error)
      __Pyx_GOTREF(__pyx_t_8);
      __Pyx_Raise(__pyx_t_8, 0, 0, 0);
      __Pyx_DECREF(__pyx_t_8); __pyx_t_8 = 0;
      __PYX_ERR(2, 1050, __pyx_L5_except_error)
    }
    goto __pyx_L5_except_error;
    __pyx_L5_except_error:;

    /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1047
 * 
 * cdef inline int import_ufunc() except -1:
 *     try:             # <<<<<<<<<<<<<<
 *         _import_umath()
 *     except Exception:
 */
    __Pyx_XGIVEREF(__pyx_t_1);
    __Pyx_XGIVEREF(__pyx_t_2);
    __Pyx_XGIVEREF(__pyx_t_3);
    __Pyx_ExceptionReset(__pyx_t_1, __pyx_t_2, __pyx_t_3);
    goto __pyx_L1_error;
    __pyx_L8_try_end:;
  }

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1046
 *         raise ImportError("numpy.core.umath failed to import")
 * 
 * cdef inline int import_ufunc() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_umath()
 */

  /* function exit code */
  __pyx_r = 0;
  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_5);
  __Pyx_XDECREF(__pyx_t_6);
  __Pyx_XDECREF(__pyx_t_7);
  __Pyx_XDECREF(__pyx_t_8);
  __Pyx_AddTraceback("numpy.import_ufunc", __pyx_clineno, __pyx_lineno, __pyx_filename);
  __pyx_r = -1;
  __pyx_L0:;
  __Pyx_TraceReturn(Py_None, 0);
  __Pyx_RefNannyFinishContext();
  return __pyx_r;
}
static struct __pyx_vtabstruct_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments;

static PyObject *__pyx_tp_new_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments(PyTypeObject *t, CYTHON_UNUSED PyObject *a, CYTHON_UNUSED PyObject *k) {
  struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *p;
  PyObject *o;
  if (likely((t->tp_flags & Py_TPFLAGS_IS_ABSTRACT) == 0)) {
    o = (*t->tp_alloc)(t, 0);
  } else {
    o = (PyObject *) PyBaseObject_Type.tp_new(t, __pyx_empty_tuple, 0);
  }
  if (unlikely(!o)) return 0;
  p = ((struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)o);
  p->__pyx_vtab = __pyx_vtabptr_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments;
  p->treat = Py_None; Py_INCREF(Py_None);
  p->ctrl = Py_None; Py_INCREF(Py_None);
  p->ctrl_d_s = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->ctrl_scaling_factor_s = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->chromosomes = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->bedGraph_filename_prefix = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->trackline = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  p->save_bedGraph = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  p->save_SPMR = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  p->no_lambda_flag = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  p->PE_mode = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  p->chr_pos_treat_ctrl = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->bedGraph_treat_filename = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->bedGraph_control_filename = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->pqtable = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->pvalue_all_done = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  p->pvalue_npeaks = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->pvalue_length = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->cutoff_analysis_filename = ((PyObject*)Py_None); Py_INCREF(Py_None);
  p->pileup_data_files = ((PyObject*)Py_None); Py_INCREF(Py_None);
  return o;
}

static void __pyx_tp_dealloc_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments(PyObject *o) {
  struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *p = (struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)o;
  #if CYTHON_USE_TP_FINALIZE
  if (unlikely(PyType_HasFeature(Py_TYPE(o), Py_TPFLAGS_HAVE_FINALIZE) && Py_TYPE(o)->tp_finalize) && !_PyGC_FINALIZED(o)) {
    if (PyObject_CallFinalizerFromDealloc(o)) return;
  }
  #endif
  PyObject_GC_UnTrack(o);
  Py_CLEAR(p->treat);
  Py_CLEAR(p->ctrl);
  Py_CLEAR(p->ctrl_d_s);
  Py_CLEAR(p->ctrl_scaling_factor_s);
  Py_CLEAR(p->chromosomes);
  Py_CLEAR(p->bedGraph_filename_prefix);
  Py_CLEAR(p->trackline);
  Py_CLEAR(p->save_bedGraph);
  Py_CLEAR(p->save_SPMR);
  Py_CLEAR(p->no_lambda_flag);
  Py_CLEAR(p->PE_mode);
  Py_CLEAR(p->chr_pos_treat_ctrl);
  Py_CLEAR(p->bedGraph_treat_filename);
  Py_CLEAR(p->bedGraph_control_filename);
  Py_CLEAR(p->pqtable);
  Py_CLEAR(p->pvalue_all_done);
  Py_CLEAR(p->pvalue_npeaks);
  Py_CLEAR(p->pvalue_length);
  Py_CLEAR(p->cutoff_analysis_filename);
  Py_CLEAR(p->pileup_data_files);
  (*Py_TYPE(o)->tp_free)(o);
}

static int __pyx_tp_traverse_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments(PyObject *o, visitproc v, void *a) {
  int e;
  struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *p = (struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)o;
  if (p->treat) {
    e = (*v)(p->treat, a); if (e) return e;
  }
  if (p->ctrl) {
    e = (*v)(p->ctrl, a); if (e) return e;
  }
  if (p->ctrl_d_s) {
    e = (*v)(p->ctrl_d_s, a); if (e) return e;
  }
  if (p->ctrl_scaling_factor_s) {
    e = (*v)(p->ctrl_scaling_factor_s, a); if (e) return e;
  }
  if (p->chromosomes) {
    e = (*v)(p->chromosomes, a); if (e) return e;
  }
  if (p->trackline) {
    e = (*v)(((PyObject *)p->trackline), a); if (e) return e;
  }
  if (p->save_bedGraph) {
    e = (*v)(((PyObject *)p->save_bedGraph), a); if (e) return e;
  }
  if (p->save_SPMR) {
    e = (*v)(((PyObject *)p->save_SPMR), a); if (e) return e;
  }
  if (p->no_lambda_flag) {
    e = (*v)(((PyObject *)p->no_lambda_flag), a); if (e) return e;
  }
  if (p->PE_mode) {
    e = (*v)(((PyObject *)p->PE_mode), a); if (e) return e;
  }
  if (p->chr_pos_treat_ctrl) {
    e = (*v)(p->chr_pos_treat_ctrl, a); if (e) return e;
  }
  if (p->pqtable) {
    e = (*v)(p->pqtable, a); if (e) return e;
  }
  if (p->pvalue_all_done) {
    e = (*v)(((PyObject *)p->pvalue_all_done), a); if (e) return e;
  }
  if (p->pvalue_npeaks) {
    e = (*v)(p->pvalue_npeaks, a); if (e) return e;
  }
  if (p->pvalue_length) {
    e = (*v)(p->pvalue_length, a); if (e) return e;
  }
  if (p->pileup_data_files) {
    e = (*v)(p->pileup_data_files, a); if (e) return e;
  }
  return 0;
}

static int __pyx_tp_clear_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments(PyObject *o) {
  PyObject* tmp;
  struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *p = (struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *)o;
  tmp = ((PyObject*)p->treat);
  p->treat = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->ctrl);
  p->ctrl = Py_None; Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->ctrl_d_s);
  p->ctrl_d_s = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->ctrl_scaling_factor_s);
  p->ctrl_scaling_factor_s = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->chromosomes);
  p->chromosomes = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->trackline);
  p->trackline = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->save_bedGraph);
  p->save_bedGraph = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->save_SPMR);
  p->save_SPMR = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->no_lambda_flag);
  p->no_lambda_flag = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->PE_mode);
  p->PE_mode = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->chr_pos_treat_ctrl);
  p->chr_pos_treat_ctrl = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->pqtable);
  p->pqtable = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->pvalue_all_done);
  p->pvalue_all_done = ((PyBoolObject *)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->pvalue_npeaks);
  p->pvalue_npeaks = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->pvalue_length);
  p->pvalue_length = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  tmp = ((PyObject*)p->pileup_data_files);
  p->pileup_data_files = ((PyObject*)Py_None); Py_INCREF(Py_None);
  Py_XDECREF(tmp);
  return 0;
}

static PyMethodDef __pyx_methods_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments[] = {
  {"destroy", (PyCFunction)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_3destroy, METH_NOARGS, __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_2destroy},
  {"set_pseudocount", (PyCFunction)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_5set_pseudocount, METH_O, 0},
  {"enable_trackline", (PyCFunction)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_7enable_trackline, METH_NOARGS, __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_6enable_trackline},
  {"call_peaks", (PyCFunction)(void*)(PyCFunctionWithKeywords)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_9call_peaks, METH_VARARGS|METH_KEYWORDS, __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_8call_peaks},
  {"call_broadpeaks", (PyCFunction)(void*)(PyCFunctionWithKeywords)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_11call_broadpeaks, METH_VARARGS|METH_KEYWORDS, __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_10call_broadpeaks},
  {"refine_peak_from_tags_distribution", (PyCFunction)(void*)(PyCFunctionWithKeywords)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_13refine_peak_from_tags_distribution, METH_VARARGS|METH_KEYWORDS, __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_12refine_peak_from_tags_distribution},
  {"__reduce_cython__", (PyCFunction)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_15__reduce_cython__, METH_NOARGS, 0},
  {"__setstate_cython__", (PyCFunction)__pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_17__setstate_cython__, METH_O, 0},
  {0, 0, 0, 0}
};

static PyTypeObject __pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments = {
  PyVarObject_HEAD_INIT(0, 0)
  "MACS2.IO.CallPeakUnit.CallerFromAlignments", /*tp_name*/
  sizeof(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments), /*tp_basicsize*/
  0, /*tp_itemsize*/
  __pyx_tp_dealloc_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments, /*tp_dealloc*/
  #if PY_VERSION_HEX < 0x030800b4
  0, /*tp_print*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4
  0, /*tp_vectorcall_offset*/
  #endif
  0, /*tp_getattr*/
  0, /*tp_setattr*/
  #if PY_MAJOR_VERSION < 3
  0, /*tp_compare*/
  #endif
  #if PY_MAJOR_VERSION >= 3
  0, /*tp_as_async*/
  #endif
  0, /*tp_repr*/
  0, /*tp_as_number*/
  0, /*tp_as_sequence*/
  0, /*tp_as_mapping*/
  0, /*tp_hash*/
  0, /*tp_call*/
  0, /*tp_str*/
  0, /*tp_getattro*/
  0, /*tp_setattro*/
  0, /*tp_as_buffer*/
  Py_TPFLAGS_DEFAULT|Py_TPFLAGS_HAVE_VERSION_TAG|Py_TPFLAGS_CHECKTYPES|Py_TPFLAGS_HAVE_NEWBUFFER|Py_TPFLAGS_BASETYPE|Py_TPFLAGS_HAVE_GC, /*tp_flags*/
  "A unit to calculate scores and call peaks from alignments --\n    FWTrack or PETrackI objects.\n\n    It will compute for each chromosome separately in order to save\n    memory usage.\n    ", /*tp_doc*/
  __pyx_tp_traverse_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments, /*tp_traverse*/
  __pyx_tp_clear_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments, /*tp_clear*/
  0, /*tp_richcompare*/
  0, /*tp_weaklistoffset*/
  0, /*tp_iter*/
  0, /*tp_iternext*/
  __pyx_methods_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments, /*tp_methods*/
  0, /*tp_members*/
  0, /*tp_getset*/
  0, /*tp_base*/
  0, /*tp_dict*/
  0, /*tp_descr_get*/
  0, /*tp_descr_set*/
  0, /*tp_dictoffset*/
  __pyx_pw_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_1__init__, /*tp_init*/
  0, /*tp_alloc*/
  __pyx_tp_new_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments, /*tp_new*/
  0, /*tp_free*/
  0, /*tp_is_gc*/
  0, /*tp_bases*/
  0, /*tp_mro*/
  0, /*tp_cache*/
  0, /*tp_subclasses*/
  0, /*tp_weaklist*/
  0, /*tp_del*/
  0, /*tp_version_tag*/
  #if PY_VERSION_HEX >= 0x030400a1
  0, /*tp_finalize*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b1
  0, /*tp_vectorcall*/
  #endif
  #if PY_VERSION_HEX >= 0x030800b4 && PY_VERSION_HEX < 0x03090000
  0, /*tp_print*/
  #endif
};

static PyMethodDef __pyx_methods[] = {
  {0, 0, 0, 0}
};

#if PY_MAJOR_VERSION >= 3
#if CYTHON_PEP489_MULTI_PHASE_INIT
static PyObject* __pyx_pymod_create(PyObject *spec, PyModuleDef *def); /*proto*/
static int __pyx_pymod_exec_CallPeakUnit(PyObject* module); /*proto*/
static PyModuleDef_Slot __pyx_moduledef_slots[] = {
  {Py_mod_create, (void*)__pyx_pymod_create},
  {Py_mod_exec, (void*)__pyx_pymod_exec_CallPeakUnit},
  {0, NULL}
};
#endif

static struct PyModuleDef __pyx_moduledef = {
    PyModuleDef_HEAD_INIT,
    "CallPeakUnit",
    __pyx_k_Module_for_Calculate_Scores_This, /* m_doc */
  #if CYTHON_PEP489_MULTI_PHASE_INIT
    0, /* m_size */
  #else
    -1, /* m_size */
  #endif
    __pyx_methods /* m_methods */,
  #if CYTHON_PEP489_MULTI_PHASE_INIT
    __pyx_moduledef_slots, /* m_slots */
  #else
    NULL, /* m_reload */
  #endif
    NULL, /* m_traverse */
    NULL, /* m_clear */
    NULL /* m_free */
};
#endif
#ifndef CYTHON_SMALL_CODE
#if defined(__clang__)
    #define CYTHON_SMALL_CODE
#elif defined(__GNUC__) && (__GNUC__ > 4 || (__GNUC__ == 4 && __GNUC_MINOR__ >= 3))
    #define CYTHON_SMALL_CODE __attribute__((cold))
#else
    #define CYTHON_SMALL_CODE
#endif
#endif

static __Pyx_StringTabEntry __pyx_string_tab[] = {
  {&__pyx_kp_b_0, __pyx_k_0, sizeof(__pyx_k_0), 0, 0, 0, 0},
  {&__pyx_kp_b_0_d, __pyx_k_0_d, sizeof(__pyx_k_0_d), 0, 0, 0, 0},
  {&__pyx_kp_b_1, __pyx_k_1, sizeof(__pyx_k_1), 0, 0, 0, 0},
  {&__pyx_kp_b_1_1, __pyx_k_1_1, sizeof(__pyx_k_1_1), 0, 0, 0, 0},
  {&__pyx_kp_b_1_2, __pyx_k_1_2, sizeof(__pyx_k_1_2), 0, 0, 0, 0},
  {&__pyx_kp_u_2f, __pyx_k_2f, sizeof(__pyx_k_2f), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Analysis_of_cutoff_vs_num_of, __pyx_k_3_Analysis_of_cutoff_vs_num_of, sizeof(__pyx_k_3_Analysis_of_cutoff_vs_num_of), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Call_peaks_for_each_chromosom, __pyx_k_3_Call_peaks_for_each_chromosom, sizeof(__pyx_k_3_Call_peaks_for_each_chromosom), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Cutoff_value_vs_broad_region, __pyx_k_3_Cutoff_value_vs_broad_region, sizeof(__pyx_k_3_Cutoff_value_vs_broad_region), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Cutoff_vs_peaks_called_will_b, __pyx_k_3_Cutoff_vs_peaks_called_will_b, sizeof(__pyx_k_3_Cutoff_vs_peaks_called_will_b), 0, 1, 0, 0},
  {&__pyx_kp_u_3_In_the_peak_calling_step_the, __pyx_k_3_In_the_peak_calling_step_the, sizeof(__pyx_k_3_In_the_peak_calling_step_the), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Pileup_will_be_based_on_seque, __pyx_k_3_Pileup_will_be_based_on_seque, sizeof(__pyx_k_3_Pileup_will_be_based_on_seque), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Pileup_will_be_based_on_seque_2, __pyx_k_3_Pileup_will_be_based_on_seque_2, sizeof(__pyx_k_3_Pileup_will_be_based_on_seque_2), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Pre_compute_pvalue_qvalue_tab, __pyx_k_3_Pre_compute_pvalue_qvalue_tab, sizeof(__pyx_k_3_Pre_compute_pvalue_qvalue_tab), 0, 1, 0, 0},
  {&__pyx_kp_u_3_SPMR_is_requested_so_pileup_w, __pyx_k_3_SPMR_is_requested_so_pileup_w, sizeof(__pyx_k_3_SPMR_is_requested_so_pileup_w), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Write_bedGraph_files_for_cont, __pyx_k_3_Write_bedGraph_files_for_cont, sizeof(__pyx_k_3_Write_bedGraph_files_for_cont), 0, 1, 0, 0},
  {&__pyx_kp_u_3_Write_bedGraph_files_for_trea, __pyx_k_3_Write_bedGraph_files_for_trea, sizeof(__pyx_k_3_Write_bedGraph_files_for_trea), 0, 1, 0, 0},
  {&__pyx_n_s_BroadPeakIO, __pyx_k_BroadPeakIO, sizeof(__pyx_k_BroadPeakIO), 0, 0, 1, 1},
  {&__pyx_kp_u_CTRL_bdg, __pyx_k_CTRL_bdg, sizeof(__pyx_k_CTRL_bdg), 0, 1, 0, 0},
  {&__pyx_n_u_CallPeakUnit, __pyx_k_CallPeakUnit, sizeof(__pyx_k_CallPeakUnit), 0, 1, 0, 1},
  {&__pyx_kp_u_CallPeakUnit_Revision, __pyx_k_CallPeakUnit_Revision, sizeof(__pyx_k_CallPeakUnit_Revision), 0, 1, 0, 0},
  {&__pyx_n_s_CallerFromAlignments, __pyx_k_CallerFromAlignments, sizeof(__pyx_k_CallerFromAlignments), 0, 0, 1, 1},
  {&__pyx_n_s_Counter, __pyx_k_Counter, sizeof(__pyx_k_Counter), 0, 0, 1, 1},
  {&__pyx_n_s_FWTrack, __pyx_k_FWTrack, sizeof(__pyx_k_FWTrack), 0, 0, 1, 1},
  {&__pyx_kp_u_Format_string_allocated_too_shor, __pyx_k_Format_string_allocated_too_shor, sizeof(__pyx_k_Format_string_allocated_too_shor), 0, 1, 0, 0},
  {&__pyx_kp_u_Format_string_allocated_too_shor_2, __pyx_k_Format_string_allocated_too_shor_2, sizeof(__pyx_k_Format_string_allocated_too_shor_2), 0, 1, 0, 0},
  {&__pyx_n_s_ImportError, __pyx_k_ImportError, sizeof(__pyx_k_ImportError), 0, 0, 1, 1},
  {&__pyx_n_s_LOG10_E, __pyx_k_LOG10_E, sizeof(__pyx_k_LOG10_E), 0, 0, 1, 1},
  {&__pyx_n_s_MACS2_IO_FixWidthTrack, __pyx_k_MACS2_IO_FixWidthTrack, sizeof(__pyx_k_MACS2_IO_FixWidthTrack), 0, 0, 1, 1},
  {&__pyx_n_s_MACS2_IO_PairedEndTrack, __pyx_k_MACS2_IO_PairedEndTrack, sizeof(__pyx_k_MACS2_IO_PairedEndTrack), 0, 0, 1, 1},
  {&__pyx_n_s_MACS2_IO_PeakIO, __pyx_k_MACS2_IO_PeakIO, sizeof(__pyx_k_MACS2_IO_PeakIO), 0, 0, 1, 1},
  {&__pyx_n_s_MACS2_Prob, __pyx_k_MACS2_Prob, sizeof(__pyx_k_MACS2_Prob), 0, 0, 1, 1},
  {&__pyx_n_s_MACS2_Signal, __pyx_k_MACS2_Signal, sizeof(__pyx_k_MACS2_Signal), 0, 0, 1, 1},
  {&__pyx_kp_u_Non_native_byte_order_not_suppor, __pyx_k_Non_native_byte_order_not_suppor, sizeof(__pyx_k_Non_native_byte_order_not_suppor), 0, 1, 0, 0},
  {&__pyx_n_s_PETrackI, __pyx_k_PETrackI, sizeof(__pyx_k_PETrackI), 0, 0, 1, 1},
  {&__pyx_n_u_PREFIX, __pyx_k_PREFIX, sizeof(__pyx_k_PREFIX), 0, 1, 0, 1},
  {&__pyx_n_s_PeakIO, __pyx_k_PeakIO, sizeof(__pyx_k_PeakIO), 0, 0, 1, 1},
  {&__pyx_n_s_RuntimeError, __pyx_k_RuntimeError, sizeof(__pyx_k_RuntimeError), 0, 0, 1, 1},
  {&__pyx_kp_u_Should_be_FWTrack_or_PETrackI_ob, __pyx_k_Should_be_FWTrack_or_PETrackI_ob, sizeof(__pyx_k_Should_be_FWTrack_or_PETrackI_ob), 0, 1, 0, 0},
  {&__pyx_kp_u_Start_to_calculate_pvalue_stat, __pyx_k_Start_to_calculate_pvalue_stat, sizeof(__pyx_k_Start_to_calculate_pvalue_stat), 0, 1, 0, 0},
  {&__pyx_n_s_StopIteration, __pyx_k_StopIteration, sizeof(__pyx_k_StopIteration), 0, 0, 1, 1},
  {&__pyx_n_s_T, __pyx_k_T, sizeof(__pyx_k_T), 0, 0, 1, 1},
  {&__pyx_kp_u_TMP_txt, __pyx_k_TMP_txt, sizeof(__pyx_k_TMP_txt), 0, 1, 0, 0},
  {&__pyx_kp_u_TREAT_bdg, __pyx_k_TREAT_bdg, sizeof(__pyx_k_TREAT_bdg), 0, 1, 0, 0},
  {&__pyx_kp_u_Tao_Liu_vladimir_liu_gmail_com, __pyx_k_Tao_Liu_vladimir_liu_gmail_com, sizeof(__pyx_k_Tao_Liu_vladimir_liu_gmail_com), 0, 1, 0, 0},
  {&__pyx_n_s_TypeError, __pyx_k_TypeError, sizeof(__pyx_k_TypeError), 0, 0, 1, 1},
  {&__pyx_n_s_ValueError, __pyx_k_ValueError, sizeof(__pyx_k_ValueError), 0, 0, 1, 1},
  {&__pyx_kp_u__10, __pyx_k__10, sizeof(__pyx_k__10), 0, 1, 0, 0},
  {&__pyx_kp_b__13, __pyx_k__13, sizeof(__pyx_k__13), 0, 0, 0, 0},
  {&__pyx_kp_u__9, __pyx_k__9, sizeof(__pyx_k__9), 0, 1, 0, 0},
  {&__pyx_kp_u_access_pq_hash_for_d_times, __pyx_k_access_pq_hash_for_d_times, sizeof(__pyx_k_access_pq_hash_for_d_times), 0, 1, 0, 0},
  {&__pyx_n_s_add, __pyx_k_add, sizeof(__pyx_k_add), 0, 0, 1, 1},
  {&__pyx_n_s_add_PeakContent, __pyx_k_add_PeakContent, sizeof(__pyx_k_add_PeakContent), 0, 0, 1, 1},
  {&__pyx_n_s_arange, __pyx_k_arange, sizeof(__pyx_k_arange), 0, 0, 1, 1},
  {&__pyx_n_s_array, __pyx_k_array, sizeof(__pyx_k_array), 0, 0, 1, 1},
  {&__pyx_n_s_author, __pyx_k_author, sizeof(__pyx_k_author), 0, 0, 1, 1},
  {&__pyx_n_s_baseline_value, __pyx_k_baseline_value, sizeof(__pyx_k_baseline_value), 0, 0, 1, 1},
  {&__pyx_n_s_bedGraph_control_filename, __pyx_k_bedGraph_control_filename, sizeof(__pyx_k_bedGraph_control_filename), 0, 0, 1, 1},
  {&__pyx_n_s_bedGraph_filename_prefix, __pyx_k_bedGraph_filename_prefix, sizeof(__pyx_k_bedGraph_filename_prefix), 0, 0, 1, 1},
  {&__pyx_n_s_bedGraph_treat_filename, __pyx_k_bedGraph_treat_filename, sizeof(__pyx_k_bedGraph_treat_filename), 0, 0, 1, 1},
  {&__pyx_n_s_blockNum, __pyx_k_blockNum, sizeof(__pyx_k_blockNum), 0, 0, 1, 1},
  {&__pyx_n_s_blockSizes, __pyx_k_blockSizes, sizeof(__pyx_k_blockSizes), 0, 0, 1, 1},
  {&__pyx_n_s_blockStarts, __pyx_k_blockStarts, sizeof(__pyx_k_blockStarts), 0, 0, 1, 1},
  {&__pyx_n_s_cPickle, __pyx_k_cPickle, sizeof(__pyx_k_cPickle), 0, 0, 1, 1},
  {&__pyx_n_s_call_broadpeaks, __pyx_k_call_broadpeaks, sizeof(__pyx_k_call_broadpeaks), 0, 0, 1, 1},
  {&__pyx_n_s_call_peaks, __pyx_k_call_peaks, sizeof(__pyx_k_call_peaks), 0, 0, 1, 1},
  {&__pyx_n_s_call_summits, __pyx_k_call_summits, sizeof(__pyx_k_call_summits), 0, 0, 1, 1},
  {&__pyx_kp_u_chromosome_s_can_t_be_found_in_t, __pyx_k_chromosome_s_can_t_be_found_in_t, sizeof(__pyx_k_chromosome_s_can_t_be_found_in_t), 0, 1, 0, 0},
  {&__pyx_kp_u_chromosome_s_is_not_valid, __pyx_k_chromosome_s_is_not_valid, sizeof(__pyx_k_chromosome_s_is_not_valid), 0, 1, 0, 0},
  {&__pyx_n_s_cline_in_traceback, __pyx_k_cline_in_traceback, sizeof(__pyx_k_cline_in_traceback), 0, 0, 1, 1},
  {&__pyx_n_s_close, __pyx_k_close, sizeof(__pyx_k_close), 0, 0, 1, 1},
  {&__pyx_n_s_collections, __pyx_k_collections, sizeof(__pyx_k_collections), 0, 0, 1, 1},
  {&__pyx_kp_u_control_lambda_bdg, __pyx_k_control_lambda_bdg, sizeof(__pyx_k_control_lambda_bdg), 0, 1, 0, 0},
  {&__pyx_n_s_copy, __pyx_k_copy, sizeof(__pyx_k_copy), 0, 0, 1, 1},
  {&__pyx_n_s_ctrl, __pyx_k_ctrl, sizeof(__pyx_k_ctrl), 0, 0, 1, 1},
  {&__pyx_n_s_ctrl_d_s, __pyx_k_ctrl_d_s, sizeof(__pyx_k_ctrl_d_s), 0, 0, 1, 1},
  {&__pyx_n_s_ctrl_scaling_factor_s, __pyx_k_ctrl_scaling_factor_s, sizeof(__pyx_k_ctrl_scaling_factor_s), 0, 0, 1, 1},
  {&__pyx_n_s_cutoff, __pyx_k_cutoff, sizeof(__pyx_k_cutoff), 0, 0, 1, 1},
  {&__pyx_n_s_cutoff_analysis, __pyx_k_cutoff_analysis, sizeof(__pyx_k_cutoff_analysis), 0, 0, 1, 1},
  {&__pyx_n_s_cutoff_analysis_filename, __pyx_k_cutoff_analysis_filename, sizeof(__pyx_k_cutoff_analysis_filename), 0, 0, 1, 1},
  {&__pyx_n_s_d, __pyx_k_d, sizeof(__pyx_k_d), 0, 0, 1, 1},
  {&__pyx_n_u_d, __pyx_k_d, sizeof(__pyx_k_d), 0, 1, 0, 1},
  {&__pyx_kp_b_d_2, __pyx_k_d_2, sizeof(__pyx_k_d_2), 0, 0, 0, 0},
  {&__pyx_n_s_debug, __pyx_k_debug, sizeof(__pyx_k_debug), 0, 0, 1, 1},
  {&__pyx_n_s_destroy, __pyx_k_destroy, sizeof(__pyx_k_destroy), 0, 0, 1, 1},
  {&__pyx_n_s_directional, __pyx_k_directional, sizeof(__pyx_k_directional), 0, 0, 1, 1},
  {&__pyx_n_s_doc, __pyx_k_doc, sizeof(__pyx_k_doc), 0, 0, 1, 1},
  {&__pyx_n_s_dtype, __pyx_k_dtype, sizeof(__pyx_k_dtype), 0, 0, 1, 1},
  {&__pyx_n_s_dump, __pyx_k_dump, sizeof(__pyx_k_dump), 0, 0, 1, 1},
  {&__pyx_n_s_enable_trackline, __pyx_k_enable_trackline, sizeof(__pyx_k_enable_trackline), 0, 0, 1, 1},
  {&__pyx_n_u_end, __pyx_k_end, sizeof(__pyx_k_end), 0, 1, 0, 1},
  {&__pyx_n_s_end_shift, __pyx_k_end_shift, sizeof(__pyx_k_end_shift), 0, 0, 1, 1},
  {&__pyx_n_s_enforce_peakyness, __pyx_k_enforce_peakyness, sizeof(__pyx_k_enforce_peakyness), 0, 0, 1, 1},
  {&__pyx_n_s_enforce_valleys, __pyx_k_enforce_valleys, sizeof(__pyx_k_enforce_valleys), 0, 0, 1, 1},
  {&__pyx_n_u_f, __pyx_k_f, sizeof(__pyx_k_f), 0, 1, 0, 1},
  {&__pyx_n_u_fc, __pyx_k_fc, sizeof(__pyx_k_fc), 0, 1, 0, 1},
  {&__pyx_n_u_float32, __pyx_k_float32, sizeof(__pyx_k_float32), 0, 1, 0, 1},
  {&__pyx_n_s_fold_change, __pyx_k_fold_change, sizeof(__pyx_k_fold_change), 0, 0, 1, 1},
  {&__pyx_n_s_get, __pyx_k_get, sizeof(__pyx_k_get), 0, 0, 1, 1},
  {&__pyx_n_s_get_chr_names, __pyx_k_get_chr_names, sizeof(__pyx_k_get_chr_names), 0, 0, 1, 1},
  {&__pyx_n_s_get_data_from_chrom, __pyx_k_get_data_from_chrom, sizeof(__pyx_k_get_data_from_chrom), 0, 0, 1, 1},
  {&__pyx_n_s_getstate, __pyx_k_getstate, sizeof(__pyx_k_getstate), 0, 0, 1, 1},
  {&__pyx_n_s_import, __pyx_k_import, sizeof(__pyx_k_import), 0, 0, 1, 1},
  {&__pyx_n_s_info, __pyx_k_info, sizeof(__pyx_k_info), 0, 0, 1, 1},
  {&__pyx_n_u_int32, __pyx_k_int32, sizeof(__pyx_k_int32), 0, 1, 0, 1},
  {&__pyx_n_s_intersection, __pyx_k_intersection, sizeof(__pyx_k_intersection), 0, 0, 1, 1},
  {&__pyx_n_s_isfile, __pyx_k_isfile, sizeof(__pyx_k_isfile), 0, 0, 1, 1},
  {&__pyx_n_s_join, __pyx_k_join, sizeof(__pyx_k_join), 0, 0, 1, 1},
  {&__pyx_n_s_keys, __pyx_k_keys, sizeof(__pyx_k_keys), 0, 0, 1, 1},
  {&__pyx_n_s_lambda_bg, __pyx_k_lambda_bg, sizeof(__pyx_k_lambda_bg), 0, 0, 1, 1},
  {&__pyx_n_u_length, __pyx_k_length, sizeof(__pyx_k_length), 0, 1, 0, 1},
  {&__pyx_n_s_linalg, __pyx_k_linalg, sizeof(__pyx_k_linalg), 0, 0, 1, 1},
  {&__pyx_n_s_load, __pyx_k_load, sizeof(__pyx_k_load), 0, 0, 1, 1},
  {&__pyx_n_s_locations, __pyx_k_locations, sizeof(__pyx_k_locations), 0, 0, 1, 1},
  {&__pyx_n_s_log10, __pyx_k_log10, sizeof(__pyx_k_log10), 0, 0, 1, 1},
  {&__pyx_n_s_logLR_dict, __pyx_k_logLR_dict, sizeof(__pyx_k_logLR_dict), 0, 0, 1, 1},
  {&__pyx_n_s_logging, __pyx_k_logging, sizeof(__pyx_k_logging), 0, 0, 1, 1},
  {&__pyx_n_s_lstsq, __pyx_k_lstsq, sizeof(__pyx_k_lstsq), 0, 0, 1, 1},
  {&__pyx_n_s_lvl1_cutoff_s, __pyx_k_lvl1_cutoff_s, sizeof(__pyx_k_lvl1_cutoff_s), 0, 0, 1, 1},
  {&__pyx_n_s_lvl1_max_gap, __pyx_k_lvl1_max_gap, sizeof(__pyx_k_lvl1_max_gap), 0, 0, 1, 1},
  {&__pyx_n_s_lvl2_cutoff_s, __pyx_k_lvl2_cutoff_s, sizeof(__pyx_k_lvl2_cutoff_s), 0, 0, 1, 1},
  {&__pyx_n_s_lvl2_max_gap, __pyx_k_lvl2_max_gap, sizeof(__pyx_k_lvl2_max_gap), 0, 0, 1, 1},
  {&__pyx_n_s_main, __pyx_k_main, sizeof(__pyx_k_main), 0, 0, 1, 1},
  {&__pyx_n_s_max_gap, __pyx_k_max_gap, sizeof(__pyx_k_max_gap), 0, 0, 1, 1},
  {&__pyx_n_s_maxima, __pyx_k_maxima, sizeof(__pyx_k_maxima), 0, 0, 1, 1},
  {&__pyx_n_s_mean, __pyx_k_mean, sizeof(__pyx_k_mean), 0, 0, 1, 1},
  {&__pyx_n_s_min_length, __pyx_k_min_length, sizeof(__pyx_k_min_length), 0, 0, 1, 1},
  {&__pyx_n_s_mkstemp, __pyx_k_mkstemp, sizeof(__pyx_k_mkstemp), 0, 0, 1, 1},
  {&__pyx_n_s_name, __pyx_k_name, sizeof(__pyx_k_name), 0, 0, 1, 1},
  {&__pyx_kp_u_ndarray_is_not_C_contiguous, __pyx_k_ndarray_is_not_C_contiguous, sizeof(__pyx_k_ndarray_is_not_C_contiguous), 0, 1, 0, 0},
  {&__pyx_kp_u_ndarray_is_not_Fortran_contiguou, __pyx_k_ndarray_is_not_Fortran_contiguou, sizeof(__pyx_k_ndarray_is_not_Fortran_contiguou), 0, 1, 0, 0},
  {&__pyx_n_s_next, __pyx_k_next, sizeof(__pyx_k_next), 0, 0, 1, 1},
  {&__pyx_n_s_nonzero, __pyx_k_nonzero, sizeof(__pyx_k_nonzero), 0, 0, 1, 1},
  {&__pyx_n_s_np, __pyx_k_np, sizeof(__pyx_k_np), 0, 0, 1, 1},
  {&__pyx_kp_u_number_of_functions_and_cutoffs, __pyx_k_number_of_functions_and_cutoffs, sizeof(__pyx_k_number_of_functions_and_cutoffs), 0, 1, 0, 0},
  {&__pyx_n_s_numpy, __pyx_k_numpy, sizeof(__pyx_k_numpy), 0, 0, 1, 1},
  {&__pyx_kp_u_numpy_core_multiarray_failed_to, __pyx_k_numpy_core_multiarray_failed_to, sizeof(__pyx_k_numpy_core_multiarray_failed_to), 0, 1, 0, 0},
  {&__pyx_kp_u_numpy_core_umath_failed_to_impor, __pyx_k_numpy_core_umath_failed_to_impor, sizeof(__pyx_k_numpy_core_umath_failed_to_impor), 0, 1, 0, 0},
  {&__pyx_n_s_ones, __pyx_k_ones, sizeof(__pyx_k_ones), 0, 0, 1, 1},
  {&__pyx_n_s_open, __pyx_k_open, sizeof(__pyx_k_open), 0, 0, 1, 1},
  {&__pyx_n_s_os, __pyx_k_os, sizeof(__pyx_k_os), 0, 0, 1, 1},
  {&__pyx_n_u_p, __pyx_k_p, sizeof(__pyx_k_p), 0, 1, 0, 1},
  {&__pyx_n_s_parse_peakname, __pyx_k_parse_peakname, sizeof(__pyx_k_parse_peakname), 0, 0, 1, 1},
  {&__pyx_n_s_path, __pyx_k_path, sizeof(__pyx_k_path), 0, 0, 1, 1},
  {&__pyx_n_s_peak_score, __pyx_k_peak_score, sizeof(__pyx_k_peak_score), 0, 0, 1, 1},
  {&__pyx_n_s_peaks, __pyx_k_peaks, sizeof(__pyx_k_peaks), 0, 0, 1, 1},
  {&__pyx_n_s_pickle, __pyx_k_pickle, sizeof(__pyx_k_pickle), 0, 0, 1, 1},
  {&__pyx_n_s_pileup, __pyx_k_pileup, sizeof(__pyx_k_pileup), 0, 0, 1, 1},
  {&__pyx_n_u_pileup, __pyx_k_pileup, sizeof(__pyx_k_pileup), 0, 1, 0, 1},
  {&__pyx_n_s_pileup_a_chromosome, __pyx_k_pileup_a_chromosome, sizeof(__pyx_k_pileup_a_chromosome), 0, 0, 1, 1},
  {&__pyx_n_s_pileup_a_chromosome_c, __pyx_k_pileup_a_chromosome_c, sizeof(__pyx_k_pileup_a_chromosome_c), 0, 0, 1, 1},
  {&__pyx_n_s_poisson_cdf, __pyx_k_poisson_cdf, sizeof(__pyx_k_poisson_cdf), 0, 0, 1, 1},
  {&__pyx_n_s_pop, __pyx_k_pop, sizeof(__pyx_k_pop), 0, 0, 1, 1},
  {&__pyx_n_s_protocol, __pyx_k_protocol, sizeof(__pyx_k_protocol), 0, 0, 1, 1},
  {&__pyx_n_s_pscore, __pyx_k_pscore, sizeof(__pyx_k_pscore), 0, 0, 1, 1},
  {&__pyx_n_u_pscore, __pyx_k_pscore, sizeof(__pyx_k_pscore), 0, 1, 0, 1},
  {&__pyx_n_s_pscore_dict, __pyx_k_pscore_dict, sizeof(__pyx_k_pscore_dict), 0, 0, 1, 1},
  {&__pyx_kp_u_pscore_qscore_npeaks_lpeaks_avel, __pyx_k_pscore_qscore_npeaks_lpeaks_avel, sizeof(__pyx_k_pscore_qscore_npeaks_lpeaks_avel), 0, 1, 0, 0},
  {&__pyx_n_s_pseudocount, __pyx_k_pseudocount, sizeof(__pyx_k_pseudocount), 0, 0, 1, 1},
  {&__pyx_n_s_pyx_vtable, __pyx_k_pyx_vtable, sizeof(__pyx_k_pyx_vtable), 0, 0, 1, 1},
  {&__pyx_n_u_q, __pyx_k_q, sizeof(__pyx_k_q), 0, 1, 0, 1},
  {&__pyx_n_s_qscore, __pyx_k_qscore, sizeof(__pyx_k_qscore), 0, 0, 1, 1},
  {&__pyx_n_u_qscore, __pyx_k_qscore, sizeof(__pyx_k_qscore), 0, 1, 0, 1},
  {&__pyx_n_s_range, __pyx_k_range, sizeof(__pyx_k_range), 0, 0, 1, 1},
  {&__pyx_n_u_rb, __pyx_k_rb, sizeof(__pyx_k_rb), 0, 1, 0, 1},
  {&__pyx_n_s_rcond, __pyx_k_rcond, sizeof(__pyx_k_rcond), 0, 0, 1, 1},
  {&__pyx_n_s_reduce, __pyx_k_reduce, sizeof(__pyx_k_reduce), 0, 0, 1, 1},
  {&__pyx_n_s_reduce_cython, __pyx_k_reduce_cython, sizeof(__pyx_k_reduce_cython), 0, 0, 1, 1},
  {&__pyx_n_s_reduce_ex, __pyx_k_reduce_ex, sizeof(__pyx_k_reduce_ex), 0, 0, 1, 1},
  {&__pyx_n_s_refcheck, __pyx_k_refcheck, sizeof(__pyx_k_refcheck), 0, 0, 1, 1},
  {&__pyx_n_s_refine_peak_from_tags_distributi, __pyx_k_refine_peak_from_tags_distributi, sizeof(__pyx_k_refine_peak_from_tags_distributi), 0, 0, 1, 1},
  {&__pyx_n_s_resize, __pyx_k_resize, sizeof(__pyx_k_resize), 0, 0, 1, 1},
  {&__pyx_n_s_reverse, __pyx_k_reverse, sizeof(__pyx_k_reverse), 0, 0, 1, 1},
  {&__pyx_n_u_right, __pyx_k_right, sizeof(__pyx_k_right), 0, 1, 0, 1},
  {&__pyx_n_s_round, __pyx_k_round, sizeof(__pyx_k_round), 0, 0, 1, 1},
  {&__pyx_n_u_s, __pyx_k_s, sizeof(__pyx_k_s), 0, 1, 0, 1},
  {&__pyx_n_s_save_SPMR, __pyx_k_save_SPMR, sizeof(__pyx_k_save_SPMR), 0, 0, 1, 1},
  {&__pyx_n_s_save_bedGraph, __pyx_k_save_bedGraph, sizeof(__pyx_k_save_bedGraph), 0, 0, 1, 1},
  {&__pyx_n_s_score, __pyx_k_score, sizeof(__pyx_k_score), 0, 0, 1, 1},
  {&__pyx_n_u_score, __pyx_k_score, sizeof(__pyx_k_score), 0, 1, 0, 1},
  {&__pyx_n_s_score_cutoff_s, __pyx_k_score_cutoff_s, sizeof(__pyx_k_score_cutoff_s), 0, 0, 1, 1},
  {&__pyx_n_s_scoring_function_symbols, __pyx_k_scoring_function_symbols, sizeof(__pyx_k_scoring_function_symbols), 0, 0, 1, 1},
  {&__pyx_n_s_searchsorted, __pyx_k_searchsorted, sizeof(__pyx_k_searchsorted), 0, 0, 1, 1},
  {&__pyx_kp_s_self_bedGraph_ctrl_f_self_bedGra, __pyx_k_self_bedGraph_ctrl_f_self_bedGra, sizeof(__pyx_k_self_bedGraph_ctrl_f_self_bedGra), 0, 0, 1, 0},
  {&__pyx_n_s_set_pseudocount, __pyx_k_set_pseudocount, sizeof(__pyx_k_set_pseudocount), 0, 0, 1, 1},
  {&__pyx_n_s_setstate, __pyx_k_setstate, sizeof(__pyx_k_setstate), 0, 0, 1, 1},
  {&__pyx_n_s_setstate_cython, __pyx_k_setstate_cython, sizeof(__pyx_k_setstate_cython), 0, 0, 1, 1},
  {&__pyx_n_s_size, __pyx_k_size, sizeof(__pyx_k_size), 0, 0, 1, 1},
  {&__pyx_n_s_sort, __pyx_k_sort, sizeof(__pyx_k_sort), 0, 0, 1, 1},
  {&__pyx_n_s_sorted, __pyx_k_sorted, sizeof(__pyx_k_sorted), 0, 0, 1, 1},
  {&__pyx_n_s_sorted_2, __pyx_k_sorted_2, sizeof(__pyx_k_sorted_2), 0, 0, 1, 1},
  {&__pyx_n_u_start, __pyx_k_start, sizeof(__pyx_k_start), 0, 1, 0, 1},
  {&__pyx_n_s_stderr_on, __pyx_k_stderr_on, sizeof(__pyx_k_stderr_on), 0, 0, 1, 1},
  {&__pyx_n_s_sum, __pyx_k_sum, sizeof(__pyx_k_sum), 0, 0, 1, 1},
  {&__pyx_n_s_summit, __pyx_k_summit, sizeof(__pyx_k_summit), 0, 0, 1, 1},
  {&__pyx_n_u_summit, __pyx_k_summit, sizeof(__pyx_k_summit), 0, 1, 0, 1},
  {&__pyx_n_s_tempfile, __pyx_k_tempfile, sizeof(__pyx_k_tempfile), 0, 0, 1, 1},
  {&__pyx_n_s_test, __pyx_k_test, sizeof(__pyx_k_test), 0, 0, 1, 1},
  {&__pyx_n_s_thickEnd, __pyx_k_thickEnd, sizeof(__pyx_k_thickEnd), 0, 0, 1, 1},
  {&__pyx_n_s_thickStart, __pyx_k_thickStart, sizeof(__pyx_k_thickStart), 0, 0, 1, 1},
  {&__pyx_n_s_time, __pyx_k_time, sizeof(__pyx_k_time), 0, 0, 1, 1},
  {&__pyx_n_s_total, __pyx_k_total, sizeof(__pyx_k_total), 0, 0, 1, 1},
  {&__pyx_kp_u_track_type_bedGraph_name_control, __pyx_k_track_type_bedGraph_name_control, sizeof(__pyx_k_track_type_bedGraph_name_control), 0, 1, 0, 0},
  {&__pyx_kp_u_track_type_bedGraph_name_treatme, __pyx_k_track_type_bedGraph_name_treatme, sizeof(__pyx_k_track_type_bedGraph_name_treatme), 0, 1, 0, 0},
  {&__pyx_n_s_treat, __pyx_k_treat, sizeof(__pyx_k_treat), 0, 0, 1, 1},
  {&__pyx_kp_u_treat_pileup_bdg, __pyx_k_treat_pileup_bdg, sizeof(__pyx_k_treat_pileup_bdg), 0, 1, 0, 0},
  {&__pyx_n_s_treat_scaling_factor, __pyx_k_treat_scaling_factor, sizeof(__pyx_k_treat_scaling_factor), 0, 0, 1, 1},
  {&__pyx_n_s_ttime, __pyx_k_ttime, sizeof(__pyx_k_ttime), 0, 0, 1, 1},
  {&__pyx_kp_u_unknown_dtype_code_in_numpy_pxd, __pyx_k_unknown_dtype_code_in_numpy_pxd, sizeof(__pyx_k_unknown_dtype_code_in_numpy_pxd), 0, 1, 0, 0},
  {&__pyx_n_s_unlink, __pyx_k_unlink, sizeof(__pyx_k_unlink), 0, 0, 1, 1},
  {&__pyx_n_s_values, __pyx_k_values, sizeof(__pyx_k_values), 0, 0, 1, 1},
  {&__pyx_n_s_version, __pyx_k_version, sizeof(__pyx_k_version), 0, 0, 1, 1},
  {&__pyx_n_s_vstack, __pyx_k_vstack, sizeof(__pyx_k_vstack), 0, 0, 1, 1},
  {&__pyx_n_u_w, __pyx_k_w, sizeof(__pyx_k_w), 0, 1, 0, 1},
  {&__pyx_n_u_wb, __pyx_k_wb, sizeof(__pyx_k_wb), 0, 1, 0, 1},
  {&__pyx_n_s_window_size, __pyx_k_window_size, sizeof(__pyx_k_window_size), 0, 0, 1, 1},
  {&__pyx_n_s_write, __pyx_k_write, sizeof(__pyx_k_write), 0, 0, 1, 1},
  {&__pyx_n_s_zeros, __pyx_k_zeros, sizeof(__pyx_k_zeros), 0, 0, 1, 1},
  {&__pyx_n_s_zip, __pyx_k_zip, sizeof(__pyx_k_zip), 0, 0, 1, 1},
  {0, 0, 0, 0, 0, 0, 0}
};
static CYTHON_SMALL_CODE int __Pyx_InitCachedBuiltins(void) {
  __pyx_builtin_range = __Pyx_GetBuiltinName(__pyx_n_s_range); if (!__pyx_builtin_range) __PYX_ERR(0, 132, __pyx_L1_error)
  __pyx_builtin_sum = __Pyx_GetBuiltinName(__pyx_n_s_sum); if (!__pyx_builtin_sum) __PYX_ERR(0, 169, __pyx_L1_error)
  __pyx_builtin_zip = __Pyx_GetBuiltinName(__pyx_n_s_zip); if (!__pyx_builtin_zip) __PYX_ERR(0, 223, __pyx_L1_error)
  __pyx_builtin_open = __Pyx_GetBuiltinName(__pyx_n_s_open); if (!__pyx_builtin_open) __PYX_ERR(0, 491, __pyx_L1_error)
  __pyx_builtin_sorted = __Pyx_GetBuiltinName(__pyx_n_s_sorted); if (!__pyx_builtin_sorted) __PYX_ERR(0, 719, __pyx_L1_error)
  __pyx_builtin_round = __Pyx_GetBuiltinName(__pyx_n_s_round); if (!__pyx_builtin_round) __PYX_ERR(0, 769, __pyx_L1_error)
  __pyx_builtin_StopIteration = __Pyx_GetBuiltinName(__pyx_n_s_StopIteration); if (!__pyx_builtin_StopIteration) __PYX_ERR(0, 1554, __pyx_L1_error)
  __pyx_builtin_TypeError = __Pyx_GetBuiltinName(__pyx_n_s_TypeError); if (!__pyx_builtin_TypeError) __PYX_ERR(1, 2, __pyx_L1_error)
  __pyx_builtin_ValueError = __Pyx_GetBuiltinName(__pyx_n_s_ValueError); if (!__pyx_builtin_ValueError) __PYX_ERR(2, 272, __pyx_L1_error)
  __pyx_builtin_RuntimeError = __Pyx_GetBuiltinName(__pyx_n_s_RuntimeError); if (!__pyx_builtin_RuntimeError) __PYX_ERR(2, 856, __pyx_L1_error)
  __pyx_builtin_ImportError = __Pyx_GetBuiltinName(__pyx_n_s_ImportError); if (!__pyx_builtin_ImportError) __PYX_ERR(2, 1038, __pyx_L1_error)
  return 0;
  __pyx_L1_error:;
  return -1;
}

static CYTHON_SMALL_CODE int __Pyx_InitCachedConstants(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_InitCachedConstants", 0);

  /* "MACS2/IO/CallPeakUnit.pyx":104
 *     i = x.shape[0] // 2
 *     x.resize( 100000 if i > 100000 else i, refcheck=False)
 *     x.resize( 0, refcheck=False)             # <<<<<<<<<<<<<<
 *     return
 * 
 */
  __pyx_tuple_ = PyTuple_Pack(1, __pyx_int_0); if (unlikely(!__pyx_tuple_)) __PYX_ERR(0, 104, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple_);
  __Pyx_GIVEREF(__pyx_tuple_);

  /* "MACS2/IO/CallPeakUnit.pyx":287
 *         rsq = 1 - sse/sst
 *         #print i, x[i], y[i], m, c, rsq
 *     return ( 1.0, 1.0 )             # <<<<<<<<<<<<<<
 * 
 * 
 */
  __pyx_tuple__2 = PyTuple_Pack(2, __pyx_float_1_0, __pyx_float_1_0); if (unlikely(!__pyx_tuple__2)) __PYX_ERR(0, 287, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__2);
  __Pyx_GIVEREF(__pyx_tuple__2);

  /* "MACS2/IO/CallPeakUnit.pyx":398
 *             self.PE_mode = True
 *         else:
 *             raise Exception("Should be FWTrack or PETrackI object!")             # <<<<<<<<<<<<<<
 * 
 *         self.treat = treat
 */
  __pyx_tuple__5 = PyTuple_Pack(1, __pyx_kp_u_Should_be_FWTrack_or_PETrackI_ob); if (unlikely(!__pyx_tuple__5)) __PYX_ERR(0, 398, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__5);
  __Pyx_GIVEREF(__pyx_tuple__5);

  /* "MACS2/IO/CallPeakUnit.pyx":442
 *         self.pvalue_length = {}
 *         self.pvalue_npeaks = {}
 *         for p in np.arange( 0.3, 10, 0.3 ): # step for optimal cutoff is 0.3 in -log10pvalue, we try from pvalue 1E-10 (-10logp=10) to 0.5 (-10logp=0.3)             # <<<<<<<<<<<<<<
 *             self.pvalue_length[ p ] = 0
 *             self.pvalue_npeaks[ p ] = 0
 */
  __pyx_tuple__6 = PyTuple_Pack(3, __pyx_float_0_3, __pyx_int_10, __pyx_float_0_3); if (unlikely(!__pyx_tuple__6)) __PYX_ERR(0, 442, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__6);
  __Pyx_GIVEREF(__pyx_tuple__6);

  /* "MACS2/IO/CallPeakUnit.pyx":528
 *                                                          directional = False )
 *         else:
 *             ctrl_pv = [treat_pv[0][-1:], np.array([self.lambda_bg,], dtype="float32")] # set a global lambda             # <<<<<<<<<<<<<<
 * 
 *         self.chr_pos_treat_ctrl = self.__chrom_pair_treat_ctrl( treat_pv, ctrl_pv)
 */
  __pyx_slice__7 = PySlice_New(__pyx_int_neg_1, Py_None, Py_None); if (unlikely(!__pyx_slice__7)) __PYX_ERR(0, 528, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_slice__7);
  __Pyx_GIVEREF(__pyx_slice__7);

  /* "MACS2/IO/CallPeakUnit.pyx":769
 * 
 *         # tmplist contains a list of log pvalue cutoffs from 0.3 to 10
 *         tmplist = [round(x,5) for x in sorted( list(np.arange(0.3, 10.0, 0.3)), reverse = True )]             # <<<<<<<<<<<<<<
 * 
 *         pvalue_stat = dict()
 */
  __pyx_tuple__8 = PyTuple_Pack(3, __pyx_float_0_3, __pyx_float_10_0, __pyx_float_0_3); if (unlikely(!__pyx_tuple__8)) __PYX_ERR(0, 769, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__8);
  __Pyx_GIVEREF(__pyx_tuple__8);

  /* "(tree fragment)":2
 * def __reduce_cython__(self):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")             # <<<<<<<<<<<<<<
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 */
  __pyx_tuple__14 = PyTuple_Pack(1, __pyx_kp_s_self_bedGraph_ctrl_f_self_bedGra); if (unlikely(!__pyx_tuple__14)) __PYX_ERR(1, 2, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__14);
  __Pyx_GIVEREF(__pyx_tuple__14);

  /* "(tree fragment)":4
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")
 * def __setstate_cython__(self, __pyx_state):
 *     raise TypeError("self.bedGraph_ctrl_f,self.bedGraph_treat_f cannot be converted to a Python object for pickling")             # <<<<<<<<<<<<<<
 */
  __pyx_tuple__15 = PyTuple_Pack(1, __pyx_kp_s_self_bedGraph_ctrl_f_self_bedGra); if (unlikely(!__pyx_tuple__15)) __PYX_ERR(1, 4, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__15);
  __Pyx_GIVEREF(__pyx_tuple__15);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":272
 *             if ((flags & pybuf.PyBUF_C_CONTIGUOUS == pybuf.PyBUF_C_CONTIGUOUS)
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_C_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not C contiguous")             # <<<<<<<<<<<<<<
 * 
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)
 */
  __pyx_tuple__16 = PyTuple_Pack(1, __pyx_kp_u_ndarray_is_not_C_contiguous); if (unlikely(!__pyx_tuple__16)) __PYX_ERR(2, 272, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__16);
  __Pyx_GIVEREF(__pyx_tuple__16);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":276
 *             if ((flags & pybuf.PyBUF_F_CONTIGUOUS == pybuf.PyBUF_F_CONTIGUOUS)
 *                 and not PyArray_CHKFLAGS(self, NPY_ARRAY_F_CONTIGUOUS)):
 *                 raise ValueError(u"ndarray is not Fortran contiguous")             # <<<<<<<<<<<<<<
 * 
 *             info.buf = PyArray_DATA(self)
 */
  __pyx_tuple__17 = PyTuple_Pack(1, __pyx_kp_u_ndarray_is_not_Fortran_contiguou); if (unlikely(!__pyx_tuple__17)) __PYX_ERR(2, 276, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__17);
  __Pyx_GIVEREF(__pyx_tuple__17);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":306
 *                 if ((descr.byteorder == c'>' and little_endian) or
 *                     (descr.byteorder == c'<' and not little_endian)):
 *                     raise ValueError(u"Non-native byte order not supported")             # <<<<<<<<<<<<<<
 *                 if   t == NPY_BYTE:        f = "b"
 *                 elif t == NPY_UBYTE:       f = "B"
 */
  __pyx_tuple__18 = PyTuple_Pack(1, __pyx_kp_u_Non_native_byte_order_not_suppor); if (unlikely(!__pyx_tuple__18)) __PYX_ERR(2, 306, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__18);
  __Pyx_GIVEREF(__pyx_tuple__18);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":856
 * 
 *         if (end - f) - <int>(new_offset - offset[0]) < 15:
 *             raise RuntimeError(u"Format string allocated too short, see comment in numpy.pxd")             # <<<<<<<<<<<<<<
 * 
 *         if ((child.byteorder == c'>' and little_endian) or
 */
  __pyx_tuple__19 = PyTuple_Pack(1, __pyx_kp_u_Format_string_allocated_too_shor); if (unlikely(!__pyx_tuple__19)) __PYX_ERR(2, 856, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__19);
  __Pyx_GIVEREF(__pyx_tuple__19);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":880
 *             t = child.type_num
 *             if end - f < 5:
 *                 raise RuntimeError(u"Format string allocated too short.")             # <<<<<<<<<<<<<<
 * 
 *             # Until ticket #99 is fixed, use integers to avoid warnings
 */
  __pyx_tuple__20 = PyTuple_Pack(1, __pyx_kp_u_Format_string_allocated_too_shor_2); if (unlikely(!__pyx_tuple__20)) __PYX_ERR(2, 880, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__20);
  __Pyx_GIVEREF(__pyx_tuple__20);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1038
 *         _import_array()
 *     except Exception:
 *         raise ImportError("numpy.core.multiarray failed to import")             # <<<<<<<<<<<<<<
 * 
 * cdef inline int import_umath() except -1:
 */
  __pyx_tuple__21 = PyTuple_Pack(1, __pyx_kp_u_numpy_core_multiarray_failed_to); if (unlikely(!__pyx_tuple__21)) __PYX_ERR(2, 1038, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__21);
  __Pyx_GIVEREF(__pyx_tuple__21);

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1044
 *         _import_umath()
 *     except Exception:
 *         raise ImportError("numpy.core.umath failed to import")             # <<<<<<<<<<<<<<
 * 
 * cdef inline int import_ufunc() except -1:
 */
  __pyx_tuple__22 = PyTuple_Pack(1, __pyx_kp_u_numpy_core_umath_failed_to_impor); if (unlikely(!__pyx_tuple__22)) __PYX_ERR(2, 1044, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_tuple__22);
  __Pyx_GIVEREF(__pyx_tuple__22);
  __Pyx_RefNannyFinishContext();
  return 0;
  __pyx_L1_error:;
  __Pyx_RefNannyFinishContext();
  return -1;
}

static CYTHON_SMALL_CODE int __Pyx_InitGlobals(void) {
  __pyx_umethod_PyDict_Type_get.type = (PyObject*)&PyDict_Type;
  __pyx_umethod_PyDict_Type_keys.type = (PyObject*)&PyDict_Type;
  __pyx_umethod_PyDict_Type_pop.type = (PyObject*)&PyDict_Type;
  __pyx_umethod_PyDict_Type_values.type = (PyObject*)&PyDict_Type;
  __pyx_umethod_PySet_Type_intersection.type = (PyObject*)&PySet_Type;
  if (__Pyx_InitStrings(__pyx_string_tab) < 0) __PYX_ERR(0, 1, __pyx_L1_error);
  __pyx_float_0_0 = PyFloat_FromDouble(0.0); if (unlikely(!__pyx_float_0_0)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_0_2 = PyFloat_FromDouble(0.2); if (unlikely(!__pyx_float_0_2)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_0_3 = PyFloat_FromDouble(0.3); if (unlikely(!__pyx_float_0_3)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_1_0 = PyFloat_FromDouble(1.0); if (unlikely(!__pyx_float_1_0)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_1e6 = PyFloat_FromDouble(1e6); if (unlikely(!__pyx_float_1e6)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_0_02 = PyFloat_FromDouble(0.02); if (unlikely(!__pyx_float_0_02)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_10_0 = PyFloat_FromDouble(10.0); if (unlikely(!__pyx_float_10_0)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_0_43429448190325176 = PyFloat_FromDouble(0.43429448190325176); if (unlikely(!__pyx_float_0_43429448190325176)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_float_neg_1_0 = PyFloat_FromDouble(-1.0); if (unlikely(!__pyx_float_neg_1_0)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_0 = PyInt_FromLong(0); if (unlikely(!__pyx_int_0)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_1 = PyInt_FromLong(1); if (unlikely(!__pyx_int_1)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_2 = PyInt_FromLong(2); if (unlikely(!__pyx_int_2)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_5 = PyInt_FromLong(5); if (unlikely(!__pyx_int_5)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_10 = PyInt_FromLong(10); if (unlikely(!__pyx_int_10)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_200 = PyInt_FromLong(200); if (unlikely(!__pyx_int_200)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_1000 = PyInt_FromLong(1000); if (unlikely(!__pyx_int_1000)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_10000 = PyInt_FromLong(10000L); if (unlikely(!__pyx_int_10000)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_100000 = PyInt_FromLong(100000L); if (unlikely(!__pyx_int_100000)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_int_neg_1 = PyInt_FromLong(-1); if (unlikely(!__pyx_int_neg_1)) __PYX_ERR(0, 1, __pyx_L1_error)
  return 0;
  __pyx_L1_error:;
  return -1;
}

static CYTHON_SMALL_CODE int __Pyx_modinit_global_init_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_variable_export_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_function_export_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_type_init_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_type_import_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_variable_import_code(void); /*proto*/
static CYTHON_SMALL_CODE int __Pyx_modinit_function_import_code(void); /*proto*/

static int __Pyx_modinit_global_init_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_global_init_code", 0);
  /*--- Global init code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_variable_export_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_variable_export_code", 0);
  /*--- Variable export code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_function_export_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_function_export_code", 0);
  /*--- Function export code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_type_init_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_type_init_code", 0);
  /*--- Type init code ---*/
  __pyx_vtabptr_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments = &__pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.destroy = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, int __pyx_skip_dispatch))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_destroy;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.set_pseudocount = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, __pyx_t_5numpy_float32_t, int __pyx_skip_dispatch))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_set_pseudocount;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.enable_trackline = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, int __pyx_skip_dispatch))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_enable_trackline;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___pileup_treat_ctrl_a_chromosome = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pileup_treat_ctrl_a_chromosome;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___chrom_pair_treat_ctrl = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_pair_treat_ctrl;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_score = (PyArrayObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *, PyObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_score;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_pvalue_qvalue_table = (void (*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_pvalue_qvalue_table;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___pre_computes = (void (*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes *__pyx_optional_args))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___pre_computes;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.call_peaks = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks *__pyx_optional_args))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_peaks;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___chrom_call_peak_using_certain_criteria = (void (*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, PyBoolObject *, PyBoolObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_call_peak_using_certain_criteria;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___close_peak_wo_subpeaks = (PyBoolObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks *__pyx_optional_args))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_wo_subpeaks;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___close_peak_with_subpeaks = (PyBoolObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks *__pyx_optional_args))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_with_subpeaks;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_pscore = (PyArrayObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_pscore;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_qscore = (PyArrayObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_qscore;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_logLR = (PyArrayObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_logLR;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_logFE = (PyArrayObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_logFE;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_FE = (PyArrayObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_FE;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___cal_subtraction = (PyArrayObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyArrayObject *, PyArrayObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___cal_subtraction;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___write_bedGraph_for_a_chromosome = (PyBoolObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___write_bedGraph_for_a_chromosome;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.call_broadpeaks = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks *__pyx_optional_args))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_call_broadpeaks;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___chrom_call_broadpeak_using_certain_criteria = (void (*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, PyObject *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, __pyx_t_5numpy_int32_t, PyBoolObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___chrom_call_broadpeak_using_certain_criteria;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___close_peak_for_broad_region = (PyBoolObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, __pyx_t_5numpy_int32_t, PyObject *, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region *__pyx_optional_args))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___close_peak_for_broad_region;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.__pyx___add_broadpeak = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, PyObject *, PyObject *, PyObject *))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___add_broadpeak;
  __pyx_vtable_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.refine_peak_from_tags_distribution = (PyObject *(*)(struct __pyx_obj_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments *, PyObject *, int __pyx_skip_dispatch, struct __pyx_opt_args_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution *__pyx_optional_args))__pyx_f_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments_refine_peak_from_tags_distribution;
  if (PyType_Ready(&__pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments) < 0) __PYX_ERR(0, 294, __pyx_L1_error)
  #if PY_VERSION_HEX < 0x030800B1
  __pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.tp_print = 0;
  #endif
  if ((CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP) && likely(!__pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.tp_dictoffset && __pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.tp_getattro == PyObject_GenericGetAttr)) {
    __pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.tp_getattro = __Pyx_PyObject_GenericGetAttr;
  }
  #if CYTHON_COMPILING_IN_CPYTHON
  {
    PyObject *wrapper = PyObject_GetAttrString((PyObject *)&__pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments, "__init__"); if (unlikely(!wrapper)) __PYX_ERR(0, 294, __pyx_L1_error)
    if (Py_TYPE(wrapper) == &PyWrapperDescr_Type) {
      __pyx_wrapperbase_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__ = *((PyWrapperDescrObject *)wrapper)->d_base;
      __pyx_wrapperbase_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__.doc = __pyx_doc_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__;
      ((PyWrapperDescrObject *)wrapper)->d_base = &__pyx_wrapperbase_5MACS2_2IO_12CallPeakUnit_20CallerFromAlignments___init__;
    }
  }
  #endif
  if (__Pyx_SetVtable(__pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments.tp_dict, __pyx_vtabptr_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments) < 0) __PYX_ERR(0, 294, __pyx_L1_error)
  if (PyObject_SetAttr(__pyx_m, __pyx_n_s_CallerFromAlignments, (PyObject *)&__pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments) < 0) __PYX_ERR(0, 294, __pyx_L1_error)
  if (__Pyx_setup_reduce((PyObject*)&__pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments) < 0) __PYX_ERR(0, 294, __pyx_L1_error)
  __pyx_ptype_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments = &__pyx_type_5MACS2_2IO_12CallPeakUnit_CallerFromAlignments;
  __Pyx_RefNannyFinishContext();
  return 0;
  __pyx_L1_error:;
  __Pyx_RefNannyFinishContext();
  return -1;
}

static int __Pyx_modinit_type_import_code(void) {
  __Pyx_RefNannyDeclarations
  PyObject *__pyx_t_1 = NULL;
  __Pyx_RefNannySetupContext("__Pyx_modinit_type_import_code", 0);
  /*--- Type import code ---*/
  __pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(3, 9, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_7cpython_4type_type = __Pyx_ImportType(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "type", 
  #if defined(PYPY_VERSION_NUM) && PYPY_VERSION_NUM < 0x050B0000
  sizeof(PyTypeObject),
  #else
  sizeof(PyHeapTypeObject),
  #endif
  __Pyx_ImportType_CheckSize_Warn);
   if (!__pyx_ptype_7cpython_4type_type) __PYX_ERR(3, 9, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(4, 8, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_7cpython_4bool_bool = __Pyx_ImportType(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "bool", sizeof(PyBoolObject), __Pyx_ImportType_CheckSize_Warn);
   if (!__pyx_ptype_7cpython_4bool_bool) __PYX_ERR(4, 8, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyImport_ImportModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_t_1)) __PYX_ERR(5, 15, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_7cpython_7complex_complex = __Pyx_ImportType(__pyx_t_1, __Pyx_BUILTIN_MODULE_NAME, "complex", sizeof(PyComplexObject), __Pyx_ImportType_CheckSize_Warn);
   if (!__pyx_ptype_7cpython_7complex_complex) __PYX_ERR(5, 15, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = PyImport_ImportModule("numpy"); if (unlikely(!__pyx_t_1)) __PYX_ERR(2, 206, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __pyx_ptype_5numpy_dtype = __Pyx_ImportType(__pyx_t_1, "numpy", "dtype", sizeof(PyArray_Descr), __Pyx_ImportType_CheckSize_Ignore);
   if (!__pyx_ptype_5numpy_dtype) __PYX_ERR(2, 206, __pyx_L1_error)
  __pyx_ptype_5numpy_flatiter = __Pyx_ImportType(__pyx_t_1, "numpy", "flatiter", sizeof(PyArrayIterObject), __Pyx_ImportType_CheckSize_Warn);
   if (!__pyx_ptype_5numpy_flatiter) __PYX_ERR(2, 229, __pyx_L1_error)
  __pyx_ptype_5numpy_broadcast = __Pyx_ImportType(__pyx_t_1, "numpy", "broadcast", sizeof(PyArrayMultiIterObject), __Pyx_ImportType_CheckSize_Warn);
   if (!__pyx_ptype_5numpy_broadcast) __PYX_ERR(2, 233, __pyx_L1_error)
  __pyx_ptype_5numpy_ndarray = __Pyx_ImportType(__pyx_t_1, "numpy", "ndarray", sizeof(PyArrayObject), __Pyx_ImportType_CheckSize_Ignore);
   if (!__pyx_ptype_5numpy_ndarray) __PYX_ERR(2, 242, __pyx_L1_error)
  __pyx_ptype_5numpy_ufunc = __Pyx_ImportType(__pyx_t_1, "numpy", "ufunc", sizeof(PyUFuncObject), __Pyx_ImportType_CheckSize_Warn);
   if (!__pyx_ptype_5numpy_ufunc) __PYX_ERR(2, 918, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_RefNannyFinishContext();
  return 0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_RefNannyFinishContext();
  return -1;
}

static int __Pyx_modinit_variable_import_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_variable_import_code", 0);
  /*--- Variable import code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}

static int __Pyx_modinit_function_import_code(void) {
  __Pyx_RefNannyDeclarations
  __Pyx_RefNannySetupContext("__Pyx_modinit_function_import_code", 0);
  /*--- Function import code ---*/
  __Pyx_RefNannyFinishContext();
  return 0;
}


#if PY_MAJOR_VERSION < 3
#ifdef CYTHON_NO_PYINIT_EXPORT
#define __Pyx_PyMODINIT_FUNC void
#else
#define __Pyx_PyMODINIT_FUNC PyMODINIT_FUNC
#endif
#else
#ifdef CYTHON_NO_PYINIT_EXPORT
#define __Pyx_PyMODINIT_FUNC PyObject *
#else
#define __Pyx_PyMODINIT_FUNC PyMODINIT_FUNC
#endif
#endif


#if PY_MAJOR_VERSION < 3
__Pyx_PyMODINIT_FUNC initCallPeakUnit(void) CYTHON_SMALL_CODE; /*proto*/
__Pyx_PyMODINIT_FUNC initCallPeakUnit(void)
#else
__Pyx_PyMODINIT_FUNC PyInit_CallPeakUnit(void) CYTHON_SMALL_CODE; /*proto*/
__Pyx_PyMODINIT_FUNC PyInit_CallPeakUnit(void)
#if CYTHON_PEP489_MULTI_PHASE_INIT
{
  return PyModuleDef_Init(&__pyx_moduledef);
}
static CYTHON_SMALL_CODE int __Pyx_check_single_interpreter(void) {
    #if PY_VERSION_HEX >= 0x030700A1
    static PY_INT64_T main_interpreter_id = -1;
    PY_INT64_T current_id = PyInterpreterState_GetID(PyThreadState_Get()->interp);
    if (main_interpreter_id == -1) {
        main_interpreter_id = current_id;
        return (unlikely(current_id == -1)) ? -1 : 0;
    } else if (unlikely(main_interpreter_id != current_id))
    #else
    static PyInterpreterState *main_interpreter = NULL;
    PyInterpreterState *current_interpreter = PyThreadState_Get()->interp;
    if (!main_interpreter) {
        main_interpreter = current_interpreter;
    } else if (unlikely(main_interpreter != current_interpreter))
    #endif
    {
        PyErr_SetString(
            PyExc_ImportError,
            "Interpreter change detected - this module can only be loaded into one interpreter per process.");
        return -1;
    }
    return 0;
}
static CYTHON_SMALL_CODE int __Pyx_copy_spec_to_module(PyObject *spec, PyObject *moddict, const char* from_name, const char* to_name, int allow_none) {
    PyObject *value = PyObject_GetAttrString(spec, from_name);
    int result = 0;
    if (likely(value)) {
        if (allow_none || value != Py_None) {
            result = PyDict_SetItemString(moddict, to_name, value);
        }
        Py_DECREF(value);
    } else if (PyErr_ExceptionMatches(PyExc_AttributeError)) {
        PyErr_Clear();
    } else {
        result = -1;
    }
    return result;
}
static CYTHON_SMALL_CODE PyObject* __pyx_pymod_create(PyObject *spec, CYTHON_UNUSED PyModuleDef *def) {
    PyObject *module = NULL, *moddict, *modname;
    if (__Pyx_check_single_interpreter())
        return NULL;
    if (__pyx_m)
        return __Pyx_NewRef(__pyx_m);
    modname = PyObject_GetAttrString(spec, "name");
    if (unlikely(!modname)) goto bad;
    module = PyModule_NewObject(modname);
    Py_DECREF(modname);
    if (unlikely(!module)) goto bad;
    moddict = PyModule_GetDict(module);
    if (unlikely(!moddict)) goto bad;
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "loader", "__loader__", 1) < 0)) goto bad;
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "origin", "__file__", 1) < 0)) goto bad;
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "parent", "__package__", 1) < 0)) goto bad;
    if (unlikely(__Pyx_copy_spec_to_module(spec, moddict, "submodule_search_locations", "__path__", 0) < 0)) goto bad;
    return module;
bad:
    Py_XDECREF(module);
    return NULL;
}


static CYTHON_SMALL_CODE int __pyx_pymod_exec_CallPeakUnit(PyObject *__pyx_pyinit_module)
#endif
#endif
{
  __Pyx_TraceDeclarations
  PyObject *__pyx_t_1 = NULL;
  PyObject *__pyx_t_2 = NULL;
  __Pyx_RefNannyDeclarations
  #if CYTHON_PEP489_MULTI_PHASE_INIT
  if (__pyx_m) {
    if (__pyx_m == __pyx_pyinit_module) return 0;
    PyErr_SetString(PyExc_RuntimeError, "Module 'CallPeakUnit' has already been imported. Re-initialisation is not supported.");
    return -1;
  }
  #elif PY_MAJOR_VERSION >= 3
  if (__pyx_m) return __Pyx_NewRef(__pyx_m);
  #endif
  #if CYTHON_REFNANNY
__Pyx_RefNanny = __Pyx_RefNannyImportAPI("refnanny");
if (!__Pyx_RefNanny) {
  PyErr_Clear();
  __Pyx_RefNanny = __Pyx_RefNannyImportAPI("Cython.Runtime.refnanny");
  if (!__Pyx_RefNanny)
      Py_FatalError("failed to import 'refnanny' module");
}
#endif
  __Pyx_RefNannySetupContext("__Pyx_PyMODINIT_FUNC PyInit_CallPeakUnit(void)", 0);
  if (__Pyx_check_binary_version() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #ifdef __Pxy_PyFrame_Initialize_Offsets
  __Pxy_PyFrame_Initialize_Offsets();
  #endif
  __pyx_empty_tuple = PyTuple_New(0); if (unlikely(!__pyx_empty_tuple)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_empty_bytes = PyBytes_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_bytes)) __PYX_ERR(0, 1, __pyx_L1_error)
  __pyx_empty_unicode = PyUnicode_FromStringAndSize("", 0); if (unlikely(!__pyx_empty_unicode)) __PYX_ERR(0, 1, __pyx_L1_error)
  #ifdef __Pyx_CyFunction_USED
  if (__pyx_CyFunction_init() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_FusedFunction_USED
  if (__pyx_FusedFunction_init() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_Coroutine_USED
  if (__pyx_Coroutine_init() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_Generator_USED
  if (__pyx_Generator_init() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_AsyncGen_USED
  if (__pyx_AsyncGen_init() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  #ifdef __Pyx_StopAsyncIteration_USED
  if (__pyx_StopAsyncIteration_init() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  /*--- Library function declarations ---*/
  /*--- Threads initialization code ---*/
  #if defined(__PYX_FORCE_INIT_THREADS) && __PYX_FORCE_INIT_THREADS
  #ifdef WITH_THREAD /* Python build with threading support? */
  PyEval_InitThreads();
  #endif
  #endif
  /*--- Module creation code ---*/
  #if CYTHON_PEP489_MULTI_PHASE_INIT
  __pyx_m = __pyx_pyinit_module;
  Py_INCREF(__pyx_m);
  #else
  #if PY_MAJOR_VERSION < 3
  __pyx_m = Py_InitModule4("CallPeakUnit", __pyx_methods, __pyx_k_Module_for_Calculate_Scores_This, 0, PYTHON_API_VERSION); Py_XINCREF(__pyx_m);
  #else
  __pyx_m = PyModule_Create(&__pyx_moduledef);
  #endif
  if (unlikely(!__pyx_m)) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  __pyx_d = PyModule_GetDict(__pyx_m); if (unlikely(!__pyx_d)) __PYX_ERR(0, 1, __pyx_L1_error)
  Py_INCREF(__pyx_d);
  __pyx_b = PyImport_AddModule(__Pyx_BUILTIN_MODULE_NAME); if (unlikely(!__pyx_b)) __PYX_ERR(0, 1, __pyx_L1_error)
  Py_INCREF(__pyx_b);
  __pyx_cython_runtime = PyImport_AddModule((char *) "cython_runtime"); if (unlikely(!__pyx_cython_runtime)) __PYX_ERR(0, 1, __pyx_L1_error)
  Py_INCREF(__pyx_cython_runtime);
  if (PyObject_SetAttrString(__pyx_m, "__builtins__", __pyx_b) < 0) __PYX_ERR(0, 1, __pyx_L1_error);
  /*--- Initialize various global constants etc. ---*/
  if (__Pyx_InitGlobals() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #if PY_MAJOR_VERSION < 3 && (__PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT)
  if (__Pyx_init_sys_getdefaultencoding_params() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  if (__pyx_module_is_main_MACS2__IO__CallPeakUnit) {
    if (PyObject_SetAttr(__pyx_m, __pyx_n_s_name, __pyx_n_s_main) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  }
  #if PY_MAJOR_VERSION >= 3
  {
    PyObject *modules = PyImport_GetModuleDict(); if (unlikely(!modules)) __PYX_ERR(0, 1, __pyx_L1_error)
    if (!PyDict_GetItemString(modules, "MACS2.IO.CallPeakUnit")) {
      if (unlikely(PyDict_SetItemString(modules, "MACS2.IO.CallPeakUnit", __pyx_m) < 0)) __PYX_ERR(0, 1, __pyx_L1_error)
    }
  }
  #endif
  /*--- Builtin init code ---*/
  if (__Pyx_InitCachedBuiltins() < 0) goto __pyx_L1_error;
  /*--- Constants init code ---*/
  if (__Pyx_InitCachedConstants() < 0) goto __pyx_L1_error;
  /*--- Global type/function init code ---*/
  (void)__Pyx_modinit_global_init_code();
  (void)__Pyx_modinit_variable_export_code();
  (void)__Pyx_modinit_function_export_code();
  if (unlikely(__Pyx_modinit_type_init_code() != 0)) goto __pyx_L1_error;
  if (unlikely(__Pyx_modinit_type_import_code() != 0)) goto __pyx_L1_error;
  (void)__Pyx_modinit_variable_import_code();
  (void)__Pyx_modinit_function_import_code();
  /*--- Execution code ---*/
  #if defined(__Pyx_Generator_USED) || defined(__Pyx_Coroutine_USED)
  if (__Pyx_patch_abc() < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  #endif
  __Pyx_TraceCall("__Pyx_PyMODINIT_FUNC PyInit_CallPeakUnit(void)", __pyx_f[0], 1, 0, __PYX_ERR(0, 1, __pyx_L1_error));

  /* "MACS2/IO/CallPeakUnit.pyx":17
 * # ------------------------------------
 * 
 * from collections import Counter             # <<<<<<<<<<<<<<
 * from copy import copy
 * import logging
 */
  __Pyx_TraceLine(17,0,__PYX_ERR(0, 17, __pyx_L1_error))
  __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_n_s_Counter);
  __Pyx_GIVEREF(__pyx_n_s_Counter);
  PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_Counter);
  __pyx_t_2 = __Pyx_Import(__pyx_n_s_collections, __pyx_t_1, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_2, __pyx_n_s_Counter); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 17, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_Counter, __pyx_t_1) < 0) __PYX_ERR(0, 17, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":18
 * 
 * from collections import Counter
 * from copy import copy             # <<<<<<<<<<<<<<
 * import logging
 * from time import time as ttime
 */
  __Pyx_TraceLine(18,0,__PYX_ERR(0, 18, __pyx_L1_error))
  __pyx_t_2 = PyList_New(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 18, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_n_s_copy);
  __Pyx_GIVEREF(__pyx_n_s_copy);
  PyList_SET_ITEM(__pyx_t_2, 0, __pyx_n_s_copy);
  __pyx_t_1 = __Pyx_Import(__pyx_n_s_copy, __pyx_t_2, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 18, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_ImportFrom(__pyx_t_1, __pyx_n_s_copy); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 18, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_copy, __pyx_t_2) < 0) __PYX_ERR(0, 18, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":19
 * from collections import Counter
 * from copy import copy
 * import logging             # <<<<<<<<<<<<<<
 * from time import time as ttime
 * import _pickle as cPickle
 */
  __Pyx_TraceLine(19,0,__PYX_ERR(0, 19, __pyx_L1_error))
  __pyx_t_1 = __Pyx_Import(__pyx_n_s_logging, 0, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 19, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_logging, __pyx_t_1) < 0) __PYX_ERR(0, 19, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":20
 * from copy import copy
 * import logging
 * from time import time as ttime             # <<<<<<<<<<<<<<
 * import _pickle as cPickle
 * from tempfile import mkstemp
 */
  __Pyx_TraceLine(20,0,__PYX_ERR(0, 20, __pyx_L1_error))
  __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 20, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_n_s_time);
  __Pyx_GIVEREF(__pyx_n_s_time);
  PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_time);
  __pyx_t_2 = __Pyx_Import(__pyx_n_s_time, __pyx_t_1, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 20, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_2, __pyx_n_s_time); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 20, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_ttime, __pyx_t_1) < 0) __PYX_ERR(0, 20, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":21
 * import logging
 * from time import time as ttime
 * import _pickle as cPickle             # <<<<<<<<<<<<<<
 * from tempfile import mkstemp
 * import os
 */
  __Pyx_TraceLine(21,0,__PYX_ERR(0, 21, __pyx_L1_error))
  __pyx_t_2 = __Pyx_Import(__pyx_n_s_pickle, 0, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 21, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_cPickle, __pyx_t_2) < 0) __PYX_ERR(0, 21, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":22
 * from time import time as ttime
 * import _pickle as cPickle
 * from tempfile import mkstemp             # <<<<<<<<<<<<<<
 * import os
 * 
 */
  __Pyx_TraceLine(22,0,__PYX_ERR(0, 22, __pyx_L1_error))
  __pyx_t_2 = PyList_New(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 22, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_n_s_mkstemp);
  __Pyx_GIVEREF(__pyx_n_s_mkstemp);
  PyList_SET_ITEM(__pyx_t_2, 0, __pyx_n_s_mkstemp);
  __pyx_t_1 = __Pyx_Import(__pyx_n_s_tempfile, __pyx_t_2, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 22, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_ImportFrom(__pyx_t_1, __pyx_n_s_mkstemp); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 22, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_mkstemp, __pyx_t_2) < 0) __PYX_ERR(0, 22, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":23
 * import _pickle as cPickle
 * from tempfile import mkstemp
 * import os             # <<<<<<<<<<<<<<
 * 
 * # numpy
 */
  __Pyx_TraceLine(23,0,__PYX_ERR(0, 23, __pyx_L1_error))
  __pyx_t_1 = __Pyx_Import(__pyx_n_s_os, 0, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 23, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_os, __pyx_t_1) < 0) __PYX_ERR(0, 23, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":26
 * 
 * # numpy
 * import numpy as np             # <<<<<<<<<<<<<<
 * cimport numpy as np
 * from numpy cimport uint8_t, uint16_t, uint32_t, uint64_t, int8_t, int16_t, int32_t, int64_t, float32_t, float64_t
 */
  __Pyx_TraceLine(26,0,__PYX_ERR(0, 26, __pyx_L1_error))
  __pyx_t_1 = __Pyx_Import(__pyx_n_s_numpy, 0, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 26, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_np, __pyx_t_1) < 0) __PYX_ERR(0, 26, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":45
 * 
 * # MACS2
 * from MACS2.Signal import maxima, enforce_valleys, enforce_peakyness             # <<<<<<<<<<<<<<
 * from MACS2.IO.PeakIO import PeakIO, BroadPeakIO, parse_peakname
 * from MACS2.IO.FixWidthTrack import FWTrack
 */
  __Pyx_TraceLine(45,0,__PYX_ERR(0, 45, __pyx_L1_error))
  __pyx_t_1 = PyList_New(3); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_n_s_maxima);
  __Pyx_GIVEREF(__pyx_n_s_maxima);
  PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_maxima);
  __Pyx_INCREF(__pyx_n_s_enforce_valleys);
  __Pyx_GIVEREF(__pyx_n_s_enforce_valleys);
  PyList_SET_ITEM(__pyx_t_1, 1, __pyx_n_s_enforce_valleys);
  __Pyx_INCREF(__pyx_n_s_enforce_peakyness);
  __Pyx_GIVEREF(__pyx_n_s_enforce_peakyness);
  PyList_SET_ITEM(__pyx_t_1, 2, __pyx_n_s_enforce_peakyness);
  __pyx_t_2 = __Pyx_Import(__pyx_n_s_MACS2_Signal, __pyx_t_1, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_2, __pyx_n_s_maxima); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_maxima, __pyx_t_1) < 0) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_2, __pyx_n_s_enforce_valleys); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_enforce_valleys, __pyx_t_1) < 0) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_2, __pyx_n_s_enforce_peakyness); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_enforce_peakyness, __pyx_t_1) < 0) __PYX_ERR(0, 45, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":46
 * # MACS2
 * from MACS2.Signal import maxima, enforce_valleys, enforce_peakyness
 * from MACS2.IO.PeakIO import PeakIO, BroadPeakIO, parse_peakname             # <<<<<<<<<<<<<<
 * from MACS2.IO.FixWidthTrack import FWTrack
 * from MACS2.IO.PairedEndTrack import PETrackI
 */
  __Pyx_TraceLine(46,0,__PYX_ERR(0, 46, __pyx_L1_error))
  __pyx_t_2 = PyList_New(3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_n_s_PeakIO);
  __Pyx_GIVEREF(__pyx_n_s_PeakIO);
  PyList_SET_ITEM(__pyx_t_2, 0, __pyx_n_s_PeakIO);
  __Pyx_INCREF(__pyx_n_s_BroadPeakIO);
  __Pyx_GIVEREF(__pyx_n_s_BroadPeakIO);
  PyList_SET_ITEM(__pyx_t_2, 1, __pyx_n_s_BroadPeakIO);
  __Pyx_INCREF(__pyx_n_s_parse_peakname);
  __Pyx_GIVEREF(__pyx_n_s_parse_peakname);
  PyList_SET_ITEM(__pyx_t_2, 2, __pyx_n_s_parse_peakname);
  __pyx_t_1 = __Pyx_Import(__pyx_n_s_MACS2_IO_PeakIO, __pyx_t_2, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_ImportFrom(__pyx_t_1, __pyx_n_s_PeakIO); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_PeakIO, __pyx_t_2) < 0) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_ImportFrom(__pyx_t_1, __pyx_n_s_BroadPeakIO); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_BroadPeakIO, __pyx_t_2) < 0) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_ImportFrom(__pyx_t_1, __pyx_n_s_parse_peakname); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_parse_peakname, __pyx_t_2) < 0) __PYX_ERR(0, 46, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":47
 * from MACS2.Signal import maxima, enforce_valleys, enforce_peakyness
 * from MACS2.IO.PeakIO import PeakIO, BroadPeakIO, parse_peakname
 * from MACS2.IO.FixWidthTrack import FWTrack             # <<<<<<<<<<<<<<
 * from MACS2.IO.PairedEndTrack import PETrackI
 * 
 */
  __Pyx_TraceLine(47,0,__PYX_ERR(0, 47, __pyx_L1_error))
  __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 47, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_n_s_FWTrack);
  __Pyx_GIVEREF(__pyx_n_s_FWTrack);
  PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_FWTrack);
  __pyx_t_2 = __Pyx_Import(__pyx_n_s_MACS2_IO_FixWidthTrack, __pyx_t_1, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 47, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_2, __pyx_n_s_FWTrack); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 47, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_FWTrack, __pyx_t_1) < 0) __PYX_ERR(0, 47, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":48
 * from MACS2.IO.PeakIO import PeakIO, BroadPeakIO, parse_peakname
 * from MACS2.IO.FixWidthTrack import FWTrack
 * from MACS2.IO.PairedEndTrack import PETrackI             # <<<<<<<<<<<<<<
 * 
 * # --------------------------------------------
 */
  __Pyx_TraceLine(48,0,__PYX_ERR(0, 48, __pyx_L1_error))
  __pyx_t_2 = PyList_New(1); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 48, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_n_s_PETrackI);
  __Pyx_GIVEREF(__pyx_n_s_PETrackI);
  PyList_SET_ITEM(__pyx_t_2, 0, __pyx_n_s_PETrackI);
  __pyx_t_1 = __Pyx_Import(__pyx_n_s_MACS2_IO_PairedEndTrack, __pyx_t_2, 0); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 48, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __pyx_t_2 = __Pyx_ImportFrom(__pyx_t_1, __pyx_n_s_PETrackI); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 48, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_PETrackI, __pyx_t_2) < 0) __PYX_ERR(0, 48, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":53
 * # cached pscore function and LR_asym functions
 * # --------------------------------------------
 * from MACS2.Prob import poisson_cdf             # <<<<<<<<<<<<<<
 * pscore_dict = dict()
 * logLR_dict = dict()
 */
  __Pyx_TraceLine(53,0,__PYX_ERR(0, 53, __pyx_L1_error))
  __pyx_t_1 = PyList_New(1); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 53, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  __Pyx_INCREF(__pyx_n_s_poisson_cdf);
  __Pyx_GIVEREF(__pyx_n_s_poisson_cdf);
  PyList_SET_ITEM(__pyx_t_1, 0, __pyx_n_s_poisson_cdf);
  __pyx_t_2 = __Pyx_Import(__pyx_n_s_MACS2_Prob, __pyx_t_1, 0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 53, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __pyx_t_1 = __Pyx_ImportFrom(__pyx_t_2, __pyx_n_s_poisson_cdf); if (unlikely(!__pyx_t_1)) __PYX_ERR(0, 53, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_1);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_poisson_cdf, __pyx_t_1) < 0) __PYX_ERR(0, 53, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_1); __pyx_t_1 = 0;
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":54
 * # --------------------------------------------
 * from MACS2.Prob import poisson_cdf
 * pscore_dict = dict()             # <<<<<<<<<<<<<<
 * logLR_dict = dict()
 * 
 */
  __Pyx_TraceLine(54,0,__PYX_ERR(0, 54, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 54, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_pscore_dict, __pyx_t_2) < 0) __PYX_ERR(0, 54, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":55
 * from MACS2.Prob import poisson_cdf
 * pscore_dict = dict()
 * logLR_dict = dict()             # <<<<<<<<<<<<<<
 * 
 * #cdef float32_t get_pscore ( int32_t x, float32_t l ):
 */
  __Pyx_TraceLine(55,0,__PYX_ERR(0, 55, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 55, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_logLR_dict, __pyx_t_2) < 0) __PYX_ERR(0, 55, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":58
 * 
 * #cdef float32_t get_pscore ( int32_t x, float32_t l ):
 * cdef float32_t get_pscore ( tuple x ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         float32_t val
 */
  __Pyx_TraceLine(58,0,__PYX_ERR(0, 58, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":69
 *         return val
 * 
 * cdef float32_t get_logLR_asym ( float32_t x, float32_t y ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         float32_t val
 */
  __Pyx_TraceLine(69,0,__PYX_ERR(0, 69, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":89
 * # constants
 * # ------------------------------------
 * __version__ = "CallPeakUnit $Revision$"             # <<<<<<<<<<<<<<
 * __author__ = "Tao Liu <vladimir.liu@gmail.com>"
 * __doc__ = "CallPeakUnit"
 */
  __Pyx_TraceLine(89,0,__PYX_ERR(0, 89, __pyx_L1_error))
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_version, __pyx_kp_u_CallPeakUnit_Revision) < 0) __PYX_ERR(0, 89, __pyx_L1_error)

  /* "MACS2/IO/CallPeakUnit.pyx":90
 * # ------------------------------------
 * __version__ = "CallPeakUnit $Revision$"
 * __author__ = "Tao Liu <vladimir.liu@gmail.com>"             # <<<<<<<<<<<<<<
 * __doc__ = "CallPeakUnit"
 * 
 */
  __Pyx_TraceLine(90,0,__PYX_ERR(0, 90, __pyx_L1_error))
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_author, __pyx_kp_u_Tao_Liu_vladimir_liu_gmail_com) < 0) __PYX_ERR(0, 90, __pyx_L1_error)

  /* "MACS2/IO/CallPeakUnit.pyx":91
 * __version__ = "CallPeakUnit $Revision$"
 * __author__ = "Tao Liu <vladimir.liu@gmail.com>"
 * __doc__ = "CallPeakUnit"             # <<<<<<<<<<<<<<
 * 
 * # ------------------------------------
 */
  __Pyx_TraceLine(91,0,__PYX_ERR(0, 91, __pyx_L1_error))
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_doc, __pyx_n_u_CallPeakUnit) < 0) __PYX_ERR(0, 91, __pyx_L1_error)

  /* "MACS2/IO/CallPeakUnit.pyx":96
 * # Misc functions
 * # ------------------------------------
 * LOG10_E = 0.43429448190325176             # <<<<<<<<<<<<<<
 * 
 * cdef void clean_up_ndarray ( np.ndarray x ):
 */
  __Pyx_TraceLine(96,0,__PYX_ERR(0, 96, __pyx_L1_error))
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_LOG10_E, __pyx_float_0_43429448190325176) < 0) __PYX_ERR(0, 96, __pyx_L1_error)

  /* "MACS2/IO/CallPeakUnit.pyx":98
 * LOG10_E = 0.43429448190325176
 * 
 * cdef void clean_up_ndarray ( np.ndarray x ):             # <<<<<<<<<<<<<<
 *     # clean numpy ndarray in two steps
 *     cdef:
 */
  __Pyx_TraceLine(98,0,__PYX_ERR(0, 98, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":107
 *     return
 * 
 * cdef inline float32_t chi2_k1_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *     return erf( sqrt(x/2) )
 * 
 */
  __Pyx_TraceLine(107,0,__PYX_ERR(0, 107, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":110
 *     return erf( sqrt(x/2) )
 * 
 * cdef inline float32_t log10_chi2_k1_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log10( erf( sqrt(x/2) ) )
 * 
 */
  __Pyx_TraceLine(110,0,__PYX_ERR(0, 110, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":113
 *   return log10( erf( sqrt(x/2) ) )
 * 
 * cdef inline float32_t chi2_k2_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return 1 - exp( -x/2 )
 * 
 */
  __Pyx_TraceLine(113,0,__PYX_ERR(0, 113, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":116
 *   return 1 - exp( -x/2 )
 * 
 * cdef inline float32_t log10_chi2_k2_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log1p( - exp( -x/2 ) ) * LOG10_E
 * 
 */
  __Pyx_TraceLine(116,0,__PYX_ERR(0, 116, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":119
 *   return log1p( - exp( -x/2 ) ) * LOG10_E
 * 
 * cdef inline float32_t chi2_k4_cdf ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return 1 - exp( -x/2 ) * ( 1 + x/2 )
 * 
 */
  __Pyx_TraceLine(119,0,__PYX_ERR(0, 119, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":122
 *   return 1 - exp( -x/2 ) * ( 1 + x/2 )
 * 
 * cdef inline float32_t log10_chi2_k4_CDF ( float32_t x ):             # <<<<<<<<<<<<<<
 *   return log1p( - exp( -x/2 ) * ( 1 + x/2 ) ) * LOG10_E
 * 
 */
  __Pyx_TraceLine(122,0,__PYX_ERR(0, 122, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":125
 *   return log1p( - exp( -x/2 ) * ( 1 + x/2 ) ) * LOG10_E
 * 
 * cdef inline np.ndarray apply_multiple_cutoffs ( list multiple_score_arrays, list multiple_cutoffs ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         int32_t i
 */
  __Pyx_TraceLine(125,0,__PYX_ERR(0, 125, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":137
 *     return ret
 * 
 * cdef inline list get_from_multiple_scores ( list multiple_score_arrays, int32_t index ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         list ret = []
 */
  __Pyx_TraceLine(137,0,__PYX_ERR(0, 137, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":147
 * 
 * 
 * cdef inline float32_t get_logFE ( float32_t x, float32_t y ):             # <<<<<<<<<<<<<<
 *     """ return 100* log10 fold enrichment with +1 pseudocount.
 *     """
 */
  __Pyx_TraceLine(147,0,__PYX_ERR(0, 147, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":152
 *     return log10( x/y )
 * 
 * cdef inline float32_t get_subtraction ( float32_t x, float32_t y):             # <<<<<<<<<<<<<<
 *     """ return subtraction.
 *     """
 */
  __Pyx_TraceLine(152,0,__PYX_ERR(0, 152, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":157
 *     return x - y
 * 
 * cdef inline list getitem_then_subtract ( list peakset, int32_t start ):             # <<<<<<<<<<<<<<
 *     cdef:
 *         list a
 */
  __Pyx_TraceLine(157,0,__PYX_ERR(0, 157, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":166
 *     return a
 * 
 * cdef inline int32_t left_sum ( data, int32_t pos, int32_t width ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */
  __Pyx_TraceLine(166,0,__PYX_ERR(0, 166, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":171
 *     return sum([data[x] for x in data if x <= pos and x >= pos - width])
 * 
 * cdef inline int32_t right_sum ( data, int32_t pos, int32_t width ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */
  __Pyx_TraceLine(171,0,__PYX_ERR(0, 171, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":176
 *     return sum([data[x] for x in data if x >= pos and x <= pos + width])
 * 
 * cdef inline int32_t left_forward ( data, int32_t pos, int32_t window_size ):             # <<<<<<<<<<<<<<
 *     return data.get(pos,0) - data.get(pos-window_size, 0)
 * 
 */
  __Pyx_TraceLine(176,0,__PYX_ERR(0, 176, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":179
 *     return data.get(pos,0) - data.get(pos-window_size, 0)
 * 
 * cdef inline int32_t right_forward ( data, int32_t pos, int32_t window_size ):             # <<<<<<<<<<<<<<
 *     return data.get(pos + window_size, 0) - data.get(pos, 0)
 * 
 */
  __Pyx_TraceLine(179,0,__PYX_ERR(0, 179, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":182
 *     return data.get(pos + window_size, 0) - data.get(pos, 0)
 * 
 * cdef wtd_find_summit(chrom, np.ndarray plus, np.ndarray minus, int32_t search_start, int32_t search_end, int32_t window_size, float32_t cutoff):             # <<<<<<<<<<<<<<
 *     """internal function to be called by refine_peak_from_tags_distribution()
 * 
 */
  __Pyx_TraceLine(182,0,__PYX_ERR(0, 182, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":214
 *     return (wtd_other_max_pos, wtd_other_max_val > cutoff)
 * 
 * cdef float32_t median_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):             # <<<<<<<<<<<<<<
 *     """
 *     """
 */
  __Pyx_TraceLine(214,0,__PYX_ERR(0, 214, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":230
 *             return tmp_v
 * 
 * cdef float32_t mean_from_value_length ( np.ndarray[np.float32_t, ndim=1] value, list length ):             # <<<<<<<<<<<<<<
 *     """take list of values and list of corresponding lengths, calculate the mean.
 *     An important function for bedGraph type of data.
 */
  __Pyx_TraceLine(230,0,__PYX_ERR(0, 230, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":255
 * 
 * 
 * cdef tuple find_optimal_cutoff( list x, list y ):             # <<<<<<<<<<<<<<
 *     """Return the best cutoff x and y.
 * 
 */
  __Pyx_TraceLine(255,0,__PYX_ERR(0, 255, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":345
 * 
 *     def __init__ (self, treat, ctrl,
 *                   int32_t d = 200, list ctrl_d_s = [200, 1000, 10000],             # <<<<<<<<<<<<<<
 *                   float32_t treat_scaling_factor = 1.0, list ctrl_scaling_factor_s = [1.0, 0.2, 0.02],
 *                   bool stderr_on = False,
 */
  __Pyx_TraceLine(345,0,__PYX_ERR(0, 345, __pyx_L1_error))
  __pyx_t_2 = PyList_New(3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 345, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_int_200);
  __Pyx_GIVEREF(__pyx_int_200);
  PyList_SET_ITEM(__pyx_t_2, 0, __pyx_int_200);
  __Pyx_INCREF(__pyx_int_1000);
  __Pyx_GIVEREF(__pyx_int_1000);
  PyList_SET_ITEM(__pyx_t_2, 1, __pyx_int_1000);
  __Pyx_INCREF(__pyx_int_10000);
  __Pyx_GIVEREF(__pyx_int_10000);
  PyList_SET_ITEM(__pyx_t_2, 2, __pyx_int_10000);
  __pyx_k__3 = ((PyObject*)__pyx_t_2);
  __Pyx_GIVEREF(__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":346
 *     def __init__ (self, treat, ctrl,
 *                   int32_t d = 200, list ctrl_d_s = [200, 1000, 10000],
 *                   float32_t treat_scaling_factor = 1.0, list ctrl_scaling_factor_s = [1.0, 0.2, 0.02],             # <<<<<<<<<<<<<<
 *                   bool stderr_on = False,
 *                   float32_t pseudocount = 1,
 */
  __Pyx_TraceLine(346,0,__PYX_ERR(0, 346, __pyx_L1_error))
  __pyx_t_2 = PyList_New(3); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 346, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __Pyx_INCREF(__pyx_float_1_0);
  __Pyx_GIVEREF(__pyx_float_1_0);
  PyList_SET_ITEM(__pyx_t_2, 0, __pyx_float_1_0);
  __Pyx_INCREF(__pyx_float_0_2);
  __Pyx_GIVEREF(__pyx_float_0_2);
  PyList_SET_ITEM(__pyx_t_2, 1, __pyx_float_0_2);
  __Pyx_INCREF(__pyx_float_0_02);
  __Pyx_GIVEREF(__pyx_float_0_02);
  PyList_SET_ITEM(__pyx_t_2, 2, __pyx_float_0_02);
  __pyx_k__4 = ((PyObject*)__pyx_t_2);
  __Pyx_GIVEREF(__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":448
 *         self.cutoff_analysis_filename = cutoff_analysis_filename.encode()
 * 
 *     cpdef destroy ( self ):             # <<<<<<<<<<<<<<
 *         """Remove temparary files for pileup values of each chromosome.
 * 
 */
  __Pyx_TraceLine(448,0,__PYX_ERR(0, 448, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":463
 *         return
 * 
 *     cpdef set_pseudocount( self, float32_t pseudocount ):             # <<<<<<<<<<<<<<
 *         self.pseudocount = pseudocount
 * 
 */
  __Pyx_TraceLine(463,0,__PYX_ERR(0, 463, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":466
 *         self.pseudocount = pseudocount
 * 
 *     cpdef enable_trackline( self ):             # <<<<<<<<<<<<<<
 *         """Turn on trackline with bedgraph output
 *         """
 */
  __Pyx_TraceLine(466,0,__PYX_ERR(0, 466, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":471
 *         self.trackline = True
 * 
 *     cdef __pileup_treat_ctrl_a_chromosome ( self, bytes chrom ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.chr_pos_treat_ctrl will
 *         be reset and assigned to the pileup values of the given
 */
  __Pyx_TraceLine(471,0,__PYX_ERR(0, 471, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":546
 *         return
 * 
 *     cdef list __chrom_pair_treat_ctrl ( self, treat_pv, ctrl_pv ):             # <<<<<<<<<<<<<<
 *         """*private* Pair treat and ctrl pileup for each region.
 * 
 */
  __Pyx_TraceLine(546,0,__PYX_ERR(0, 546, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":645
 *         return [ret_p, ret_t, ret_c]
 * 
 *     cdef np.ndarray __cal_score ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2, cal_func ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i
 */
  __Pyx_TraceLine(645,0,__PYX_ERR(0, 645, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":655
 *         return s
 * 
 *     cdef void __cal_pvalue_qvalue_table ( self ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.pqtable is built. All
 *         chromosomes will be iterated. So it will take some time.
 */
  __Pyx_TraceLine(655,0,__PYX_ERR(0, 655, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":736
 * 
 * 
 *     cdef void __pre_computes ( self, int32_t max_gap = 50, int32_t min_length = 200 ):             # <<<<<<<<<<<<<<
 *         """After this function is called, self.pqtable and self.pvalue_length is built. All
 *         chromosomes will be iterated. So it will take some time.
 */
  __Pyx_TraceLine(736,0,__PYX_ERR(0, 736, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":896
 *         return
 * 
 *     cpdef call_peaks ( self, list scoring_function_symbols, list score_cutoff_s, int32_t min_length = 200,             # <<<<<<<<<<<<<<
 *                        int32_t max_gap = 50, bool call_summits = False, bool cutoff_analysis = False ):
 *         """Call peaks for all chromosomes. Return a PeakIO object.
 */
  __Pyx_TraceLine(896,0,__PYX_ERR(0, 896, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":962
 *         return peaks
 * 
 *     cdef void __chrom_call_peak_using_certain_criteria ( self, peaks, bytes chrom, list scoring_function_s, list score_cutoff_s, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                                    int32_t max_gap, bool call_summits, bool save_bedGraph ):
 *         """ Call peaks for a chromosome.
 */
  __Pyx_TraceLine(962,0,__PYX_ERR(0, 962, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1100
 *         return
 * 
 *     cdef bool __close_peak_wo_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                           bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the peak region, output peak boundaries, peak summit
 */
  __Pyx_TraceLine(1100,0,__PYX_ERR(0, 1100, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1101
 * 
 *     cdef bool __close_peak_wo_subpeaks (self, list peak_content, peaks, int32_t min_length,
 *                                           bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):             # <<<<<<<<<<<<<<
 *         """Close the peak region, output peak boundaries, peak summit
 *         and scores, then add the peak to peakIO object.
 */
  __Pyx_TraceLine(1101,0,__PYX_ERR(0, 1101, __pyx_L1_error))
  __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1101, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_k__11 = ((PyObject*)__pyx_t_2);
  __Pyx_GIVEREF(__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1161
 *             return True
 * 
 *     cdef bool __close_peak_with_subpeaks (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                          bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[],
 *                                          float32_t min_valley = 0.9 ):
 */
  __Pyx_TraceLine(1161,0,__PYX_ERR(0, 1161, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1162
 * 
 *     cdef bool __close_peak_with_subpeaks (self, list peak_content, peaks, int32_t min_length,
 *                                          bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[],             # <<<<<<<<<<<<<<
 *                                          float32_t min_valley = 0.9 ):
 *         """Algorithm implemented by Ben, to profile the pileup signals
 */
  __Pyx_TraceLine(1162,0,__PYX_ERR(0, 1162, __pyx_L1_error))
  __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1162, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_k__12 = ((PyObject*)__pyx_t_2);
  __Pyx_GIVEREF(__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1248
 *         return True
 * 
 *     cdef np.ndarray __cal_pscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */
  __Pyx_TraceLine(1248,0,__PYX_ERR(0, 1248, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1273
 *         return s
 * 
 *     cdef np.ndarray __cal_qscore ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */
  __Pyx_TraceLine(1273,0,__PYX_ERR(0, 1273, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1296
 *         return s
 * 
 *     cdef np.ndarray __cal_logLR ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */
  __Pyx_TraceLine(1296,0,__PYX_ERR(0, 1296, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1318
 *         return s
 * 
 *     cdef np.ndarray __cal_logFE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */
  __Pyx_TraceLine(1318,0,__PYX_ERR(0, 1318, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1340
 *         return s
 * 
 *     cdef np.ndarray __cal_FE ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */
  __Pyx_TraceLine(1340,0,__PYX_ERR(0, 1340, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1362
 *         return s
 * 
 *     cdef np.ndarray __cal_subtraction ( self, np.ndarray[np.float32_t, ndim=1] array1, np.ndarray[np.float32_t, ndim=1] array2 ):             # <<<<<<<<<<<<<<
 *         cdef:
 *             int64_t i, array1_size
 */
  __Pyx_TraceLine(1362,0,__PYX_ERR(0, 1362, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1385
 * 
 * 
 *     cdef bool __write_bedGraph_for_a_chromosome ( self, bytes chrom ):             # <<<<<<<<<<<<<<
 *         """Write treat/control values for a certain chromosome into a
 *         specified file handler.
 */
  __Pyx_TraceLine(1385,0,__PYX_ERR(0, 1385, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1461
 *         return True
 * 
 *     cpdef call_broadpeaks (self, list scoring_function_symbols, list lvl1_cutoff_s, list lvl2_cutoff_s, int32_t min_length=200, int32_t lvl1_max_gap=50, int32_t lvl2_max_gap=400, bool cutoff_analysis = False):             # <<<<<<<<<<<<<<
 *         """This function try to find enriched regions within which,
 *         scores are continuously higher than a given cutoff for level
 */
  __Pyx_TraceLine(1461,0,__PYX_ERR(0, 1461, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1564
 *         return broadpeaks
 * 
 *     cdef void  __chrom_call_broadpeak_using_certain_criteria ( self, lvl1peaks, lvl2peaks, bytes chrom, list scoring_function_s, list lvl1_cutoff_s, list lvl2_cutoff_s,             # <<<<<<<<<<<<<<
 *                                                          int32_t min_length, int32_t lvl1_max_gap, int32_t lvl2_max_gap, bool save_bedGraph):
 *         """ Call peaks for a chromosome.
 */
  __Pyx_TraceLine(1564,0,__PYX_ERR(0, 1564, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1740
 *         return
 * 
 *     cdef bool __close_peak_for_broad_region (self, list peak_content, peaks, int32_t min_length,             # <<<<<<<<<<<<<<
 *                                              bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):
 *         """Close the broad peak region, output peak boundaries, peak summit
 */
  __Pyx_TraceLine(1740,0,__PYX_ERR(0, 1740, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1741
 * 
 *     cdef bool __close_peak_for_broad_region (self, list peak_content, peaks, int32_t min_length,
 *                                              bytes chrom, int32_t smoothlen, list score_array_s, list score_cutoff_s=[]):             # <<<<<<<<<<<<<<
 *         """Close the broad peak region, output peak boundaries, peak summit
 *         and scores, then add the peak to peakIO object.
 */
  __Pyx_TraceLine(1741,0,__PYX_ERR(0, 1741, __pyx_L1_error))
  __pyx_t_2 = PyList_New(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1741, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  __pyx_k__23 = ((PyObject*)__pyx_t_2);
  __Pyx_GIVEREF(__pyx_t_2);
  __pyx_t_2 = 0;

  /* "MACS2/IO/CallPeakUnit.pyx":1790
 *             return True
 * 
 *     cdef __add_broadpeak (self, bpeaks, bytes chrom, object lvl2peak, list lvl1peakset):             # <<<<<<<<<<<<<<
 *         """Internal function to create broad peak.
 * 
 */
  __Pyx_TraceLine(1790,0,__PYX_ERR(0, 1790, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1838
 *         return bpeaks
 * 
 *     cpdef refine_peak_from_tags_distribution ( self, peaks, int32_t window_size = 100, float32_t cutoff = 5 ):             # <<<<<<<<<<<<<<
 *         """Extract tags in peak, then apply func on extracted tags.
 * 
 */
  __Pyx_TraceLine(1838,0,__PYX_ERR(0, 1838, __pyx_L1_error))


  /* "MACS2/IO/CallPeakUnit.pyx":1
 * # cython: language_level=3             # <<<<<<<<<<<<<<
 * # cython: profile=True
 * # cython: linetrace=True
 */
  __Pyx_TraceLine(1,0,__PYX_ERR(0, 1, __pyx_L1_error))
  __pyx_t_2 = __Pyx_PyDict_NewPresized(0); if (unlikely(!__pyx_t_2)) __PYX_ERR(0, 1, __pyx_L1_error)
  __Pyx_GOTREF(__pyx_t_2);
  if (PyDict_SetItem(__pyx_d, __pyx_n_s_test, __pyx_t_2) < 0) __PYX_ERR(0, 1, __pyx_L1_error)
  __Pyx_DECREF(__pyx_t_2); __pyx_t_2 = 0;

  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":821
 * ctypedef npy_cdouble     complex_t
 * 
 * cdef inline object PyArray_MultiIterNew1(a):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(1, <void*>a)
 * 
 */
  __Pyx_TraceLine(821,0,__PYX_ERR(2, 821, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":824
 *     return PyArray_MultiIterNew(1, <void*>a)
 * 
 * cdef inline object PyArray_MultiIterNew2(a, b):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(2, <void*>a, <void*>b)
 * 
 */
  __Pyx_TraceLine(824,0,__PYX_ERR(2, 824, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":827
 *     return PyArray_MultiIterNew(2, <void*>a, <void*>b)
 * 
 * cdef inline object PyArray_MultiIterNew3(a, b, c):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(3, <void*>a, <void*>b, <void*> c)
 * 
 */
  __Pyx_TraceLine(827,0,__PYX_ERR(2, 827, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":830
 *     return PyArray_MultiIterNew(3, <void*>a, <void*>b, <void*> c)
 * 
 * cdef inline object PyArray_MultiIterNew4(a, b, c, d):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(4, <void*>a, <void*>b, <void*>c, <void*> d)
 * 
 */
  __Pyx_TraceLine(830,0,__PYX_ERR(2, 830, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":833
 *     return PyArray_MultiIterNew(4, <void*>a, <void*>b, <void*>c, <void*> d)
 * 
 * cdef inline object PyArray_MultiIterNew5(a, b, c, d, e):             # <<<<<<<<<<<<<<
 *     return PyArray_MultiIterNew(5, <void*>a, <void*>b, <void*>c, <void*> d, <void*> e)
 * 
 */
  __Pyx_TraceLine(833,0,__PYX_ERR(2, 833, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":836
 *     return PyArray_MultiIterNew(5, <void*>a, <void*>b, <void*>c, <void*> d, <void*> e)
 * 
 * cdef inline tuple PyDataType_SHAPE(dtype d):             # <<<<<<<<<<<<<<
 *     if PyDataType_HASSUBARRAY(d):
 *         return <tuple>d.subarray.shape
 */
  __Pyx_TraceLine(836,0,__PYX_ERR(2, 836, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":842
 *         return ()
 * 
 * cdef inline char* _util_dtypestring(dtype descr, char* f, char* end, int* offset) except NULL:             # <<<<<<<<<<<<<<
 *     # Recursive utility function used in __getbuffer__ to get format
 *     # string. The new location in the format string is returned.
 */
  __Pyx_TraceLine(842,0,__PYX_ERR(2, 842, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1022
 *     int _import_umath() except -1
 * 
 * cdef inline void set_array_base(ndarray arr, object base):             # <<<<<<<<<<<<<<
 *     Py_INCREF(base) # important to do this before stealing the reference below!
 *     PyArray_SetBaseObject(arr, base)
 */
  __Pyx_TraceLine(1022,0,__PYX_ERR(2, 1022, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1026
 *     PyArray_SetBaseObject(arr, base)
 * 
 * cdef inline object get_array_base(ndarray arr):             # <<<<<<<<<<<<<<
 *     base = PyArray_BASE(arr)
 *     if base is NULL:
 */
  __Pyx_TraceLine(1026,0,__PYX_ERR(2, 1026, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1034
 * # Versions of the import_* functions which are more suitable for
 * # Cython code.
 * cdef inline int import_array() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_array()
 */
  __Pyx_TraceLine(1034,0,__PYX_ERR(2, 1034, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1040
 *         raise ImportError("numpy.core.multiarray failed to import")
 * 
 * cdef inline int import_umath() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_umath()
 */
  __Pyx_TraceLine(1040,0,__PYX_ERR(2, 1040, __pyx_L1_error))


  /* "../../../Codes/TLPython3/lib/python3.8/site-packages/Cython/Includes/numpy/__init__.pxd":1046
 *         raise ImportError("numpy.core.umath failed to import")
 * 
 * cdef inline int import_ufunc() except -1:             # <<<<<<<<<<<<<<
 *     try:
 *         _import_umath()
 */
  __Pyx_TraceLine(1046,0,__PYX_ERR(2, 1046, __pyx_L1_error))

  __Pyx_TraceReturn(Py_None, 0);

  /*--- Wrapped vars code ---*/

  goto __pyx_L0;
  __pyx_L1_error:;
  __Pyx_XDECREF(__pyx_t_1);
  __Pyx_XDECREF(__pyx_t_2);
  if (__pyx_m) {
    if (__pyx_d) {
      __Pyx_AddTraceback("init MACS2.IO.CallPeakUnit", __pyx_clineno, __pyx_lineno, __pyx_filename);
    }
    Py_CLEAR(__pyx_m);
  } else if (!PyErr_Occurred()) {
    PyErr_SetString(PyExc_ImportError, "init MACS2.IO.CallPeakUnit");
  }
  __pyx_L0:;
  __Pyx_RefNannyFinishContext();
  #if CYTHON_PEP489_MULTI_PHASE_INIT
  return (__pyx_m != NULL) ? 0 : -1;
  #elif PY_MAJOR_VERSION >= 3
  return __pyx_m;
  #else
  return;
  #endif
}

/* --- Runtime support code --- */
/* Refnanny */
#if CYTHON_REFNANNY
static __Pyx_RefNannyAPIStruct *__Pyx_RefNannyImportAPI(const char *modname) {
    PyObject *m = NULL, *p = NULL;
    void *r = NULL;
    m = PyImport_ImportModule(modname);
    if (!m) goto end;
    p = PyObject_GetAttrString(m, "RefNannyAPI");
    if (!p) goto end;
    r = PyLong_AsVoidPtr(p);
end:
    Py_XDECREF(p);
    Py_XDECREF(m);
    return (__Pyx_RefNannyAPIStruct *)r;
}
#endif

/* PyObjectGetAttrStr */
#if CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PyObject* __Pyx_PyObject_GetAttrStr(PyObject* obj, PyObject* attr_name) {
    PyTypeObject* tp = Py_TYPE(obj);
    if (likely(tp->tp_getattro))
        return tp->tp_getattro(obj, attr_name);
#if PY_MAJOR_VERSION < 3
    if (likely(tp->tp_getattr))
        return tp->tp_getattr(obj, PyString_AS_STRING(attr_name));
#endif
    return PyObject_GetAttr(obj, attr_name);
}
#endif

/* GetBuiltinName */
static PyObject *__Pyx_GetBuiltinName(PyObject *name) {
    PyObject* result = __Pyx_PyObject_GetAttrStr(__pyx_b, name);
    if (unlikely(!result)) {
        PyErr_Format(PyExc_NameError,
#if PY_MAJOR_VERSION >= 3
            "name '%U' is not defined", name);
#else
            "name '%.200s' is not defined", PyString_AS_STRING(name));
#endif
    }
    return result;
}

/* PyErrFetchRestore */
#if CYTHON_FAST_THREAD_STATE
static CYTHON_INLINE void __Pyx_ErrRestoreInState(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb) {
    PyObject *tmp_type, *tmp_value, *tmp_tb;
    tmp_type = tstate->curexc_type;
    tmp_value = tstate->curexc_value;
    tmp_tb = tstate->curexc_traceback;
    tstate->curexc_type = type;
    tstate->curexc_value = value;
    tstate->curexc_traceback = tb;
    Py_XDECREF(tmp_type);
    Py_XDECREF(tmp_value);
    Py_XDECREF(tmp_tb);
}
static CYTHON_INLINE void __Pyx_ErrFetchInState(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb) {
    *type = tstate->curexc_type;
    *value = tstate->curexc_value;
    *tb = tstate->curexc_traceback;
    tstate->curexc_type = 0;
    tstate->curexc_value = 0;
    tstate->curexc_traceback = 0;
}
#endif

/* Profile */
#if CYTHON_PROFILE
static int __Pyx_TraceSetupAndCall(PyCodeObject** code,
                                   PyFrameObject** frame,
                                   PyThreadState* tstate,
                                   const char *funcname,
                                   const char *srcfile,
                                   int firstlineno) {
    PyObject *type, *value, *traceback;
    int retval;
    if (*frame == NULL || !CYTHON_PROFILE_REUSE_FRAME) {
        if (*code == NULL) {
            *code = __Pyx_createFrameCodeObject(funcname, srcfile, firstlineno);
            if (*code == NULL) return 0;
        }
        *frame = PyFrame_New(
            tstate,                          /*PyThreadState *tstate*/
            *code,                           /*PyCodeObject *code*/
            __pyx_d,                  /*PyObject *globals*/
            0                                /*PyObject *locals*/
        );
        if (*frame == NULL) return 0;
        if (CYTHON_TRACE && (*frame)->f_trace == NULL) {
            Py_INCREF(Py_None);
            (*frame)->f_trace = Py_None;
        }
#if PY_VERSION_HEX < 0x030400B1
    } else {
        (*frame)->f_tstate = tstate;
#endif
    }
      __Pyx_PyFrame_SetLineNumber(*frame, firstlineno);
    retval = 1;
    tstate->tracing++;
    tstate->use_tracing = 0;
    __Pyx_ErrFetchInState(tstate, &type, &value, &traceback);
    #if CYTHON_TRACE
    if (tstate->c_tracefunc)
        retval = tstate->c_tracefunc(tstate->c_traceobj, *frame, PyTrace_CALL, NULL) == 0;
    if (retval && tstate->c_profilefunc)
    #endif
        retval = tstate->c_profilefunc(tstate->c_profileobj, *frame, PyTrace_CALL, NULL) == 0;
    tstate->use_tracing = (tstate->c_profilefunc ||
                           (CYTHON_TRACE && tstate->c_tracefunc));
    tstate->tracing--;
    if (retval) {
        __Pyx_ErrRestoreInState(tstate, type, value, traceback);
        return tstate->use_tracing && retval;
    } else {
        Py_XDECREF(type);
        Py_XDECREF(value);
        Py_XDECREF(traceback);
        return -1;
    }
}
static PyCodeObject *__Pyx_createFrameCodeObject(const char *funcname, const char *srcfile, int firstlineno) {
    PyCodeObject *py_code = 0;
#if PY_MAJOR_VERSION >= 3
    py_code = PyCode_NewEmpty(srcfile, funcname, firstlineno);
    if (likely(py_code)) {
        py_code->co_flags |= CO_OPTIMIZED | CO_NEWLOCALS;
    }
#else
    PyObject *py_srcfile = 0;
    PyObject *py_funcname = 0;
    py_funcname = PyString_FromString(funcname);
    if (unlikely(!py_funcname)) goto bad;
    py_srcfile = PyString_FromString(srcfile);
    if (unlikely(!py_srcfile)) goto bad;
    py_code = PyCode_New(
        0,
        0,
        0,
        CO_OPTIMIZED | CO_NEWLOCALS,
        __pyx_empty_bytes,     /*PyObject *code,*/
        __pyx_empty_tuple,     /*PyObject *consts,*/
        __pyx_empty_tuple,     /*PyObject *names,*/
        __pyx_empty_tuple,     /*PyObject *varnames,*/
        __pyx_empty_tuple,     /*PyObject *freevars,*/
        __pyx_empty_tuple,     /*PyObject *cellvars,*/
        py_srcfile,       /*PyObject *filename,*/
        py_funcname,      /*PyObject *name,*/
        firstlineno,
        __pyx_empty_bytes      /*PyObject *lnotab*/
    );
bad:
    Py_XDECREF(py_srcfile);
    Py_XDECREF(py_funcname);
#endif
    return py_code;
}
#endif

/* PyDictVersioning */
#if CYTHON_USE_DICT_VERSIONS && CYTHON_USE_TYPE_SLOTS
static CYTHON_INLINE PY_UINT64_T __Pyx_get_tp_dict_version(PyObject *obj) {
    PyObject *dict = Py_TYPE(obj)->tp_dict;
    return likely(dict) ? __PYX_GET_DICT_VERSION(dict) : 0;
}
static CYTHON_INLINE PY_UINT64_T __Pyx_get_object_dict_version(PyObject *obj) {
    PyObject **dictptr = NULL;
    Py_ssize_t offset = Py_TYPE(obj)->tp_dictoffset;
    if (offset) {
#if CYTHON_COMPILING_IN_CPYTHON
        dictptr = (likely(offset > 0)) ? (PyObject **) ((char *)obj + offset) : _PyObject_GetDictPtr(obj);
#else
        dictptr = _PyObject_GetDictPtr(obj);
#endif
    }
    return (dictptr && *dictptr) ? __PYX_GET_DICT_VERSION(*dictptr) : 0;
}
static CYTHON_INLINE int __Pyx_object_dict_version_matches(PyObject* obj, PY_UINT64_T tp_dict_version, PY_UINT64_T obj_dict_version) {
    PyObject *dict = Py_TYPE(obj)->tp_dict;
    if (unlikely(!dict) || unlikely(tp_dict_version != __PYX_GET_DICT_VERSION(dict)))
        return 0;
    return obj_dict_version == __Pyx_get_object_dict_version(obj);
}
#endif

/* GetModuleGlobalName */
#if CYTHON_USE_DICT_VERSIONS
static PyObject *__Pyx__GetModuleGlobalName(PyObject *name, PY_UINT64_T *dict_version, PyObject **dict_cached_value)
#else
static CYTHON_INLINE PyObject *__Pyx__GetModuleGlobalName(PyObject *name)
#endif
{
    PyObject *result;
#if !CYTHON_AVOID_BORROWED_REFS
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030500A1
    result = _PyDict_GetItem_KnownHash(__pyx_d, name, ((PyASCIIObject *) name)->hash);
    __PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
    if (likely(result)) {
        return __Pyx_NewRef(result);
    } else if (unlikely(PyErr_Occurred())) {
        return NULL;
    }
#else
    result = PyDict_GetItem(__pyx_d, name);
    __PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
    if (likely(result)) {
        return __Pyx_NewRef(result);
    }
#endif
#else
    result = PyObject_GetItem(__pyx_d, name);
    __PYX_UPDATE_DICT_CACHE(__pyx_d, result, *dict_cached_value, *dict_version)
    if (likely(result)) {
        return __Pyx_NewRef(result);
    }
    PyErr_Clear();
#endif
    return __Pyx_GetBuiltinName(name);
}

/* GetItemInt */
static PyObject *__Pyx_GetItemInt_Generic(PyObject *o, PyObject* j) {
    PyObject *r;
    if (!j) return NULL;
    r = PyObject_GetItem(o, j);
    Py_DECREF(j);
    return r;
}
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_List_Fast(PyObject *o, Py_ssize_t i,
                                                              CYTHON_NCP_UNUSED int wraparound,
                                                              CYTHON_NCP_UNUSED int boundscheck) {
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    Py_ssize_t wrapped_i = i;
    if (wraparound & unlikely(i < 0)) {
        wrapped_i += PyList_GET_SIZE(o);
    }
    if ((!boundscheck) || likely(__Pyx_is_valid_index(wrapped_i, PyList_GET_SIZE(o)))) {
        PyObject *r = PyList_GET_ITEM(o, wrapped_i);
        Py_INCREF(r);
        return r;
    }
    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
#else
    return PySequence_GetItem(o, i);
#endif
}
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Tuple_Fast(PyObject *o, Py_ssize_t i,
                                                              CYTHON_NCP_UNUSED int wraparound,
                                                              CYTHON_NCP_UNUSED int boundscheck) {
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    Py_ssize_t wrapped_i = i;
    if (wraparound & unlikely(i < 0)) {
        wrapped_i += PyTuple_GET_SIZE(o);
    }
    if ((!boundscheck) || likely(__Pyx_is_valid_index(wrapped_i, PyTuple_GET_SIZE(o)))) {
        PyObject *r = PyTuple_GET_ITEM(o, wrapped_i);
        Py_INCREF(r);
        return r;
    }
    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
#else
    return PySequence_GetItem(o, i);
#endif
}
static CYTHON_INLINE PyObject *__Pyx_GetItemInt_Fast(PyObject *o, Py_ssize_t i, int is_list,
                                                     CYTHON_NCP_UNUSED int wraparound,
                                                     CYTHON_NCP_UNUSED int boundscheck) {
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS && CYTHON_USE_TYPE_SLOTS
    if (is_list || PyList_CheckExact(o)) {
        Py_ssize_t n = ((!wraparound) | likely(i >= 0)) ? i : i + PyList_GET_SIZE(o);
        if ((!boundscheck) || (likely(__Pyx_is_valid_index(n, PyList_GET_SIZE(o))))) {
            PyObject *r = PyList_GET_ITEM(o, n);
            Py_INCREF(r);
            return r;
        }
    }
    else if (PyTuple_CheckExact(o)) {
        Py_ssize_t n = ((!wraparound) | likely(i >= 0)) ? i : i + PyTuple_GET_SIZE(o);
        if ((!boundscheck) || likely(__Pyx_is_valid_index(n, PyTuple_GET_SIZE(o)))) {
            PyObject *r = PyTuple_GET_ITEM(o, n);
            Py_INCREF(r);
            return r;
        }
    } else {
        PySequenceMethods *m = Py_TYPE(o)->tp_as_sequence;
        if (likely(m && m->sq_item)) {
            if (wraparound && unlikely(i < 0) && likely(m->sq_length)) {
                Py_ssize_t l = m->sq_length(o);
                if (likely(l >= 0)) {
                    i += l;
                } else {
                    if (!PyErr_ExceptionMatches(PyExc_OverflowError))
                        return NULL;
                    PyErr_Clear();
                }
            }
            return m->sq_item(o, i);
        }
    }
#else
    if (is_list || PySequence_Check(o)) {
        return PySequence_GetItem(o, i);
    }
#endif
    return __Pyx_GetItemInt_Generic(o, PyInt_FromSsize_t(i));
}

/* ObjectGetItem */
#if CYTHON_USE_TYPE_SLOTS
static PyObject *__Pyx_PyObject_GetIndex(PyObject *obj, PyObject* index) {
    PyObject *runerr;
    Py_ssize_t key_value;
    PySequenceMethods *m = Py_TYPE(obj)->tp_as_sequence;
    if (unlikely(!(m && m->sq_item))) {
        PyErr_Format(PyExc_TypeError, "'%.200s' object is not subscriptable", Py_TYPE(obj)->tp_name);
        return NULL;
    }
    key_value = __Pyx_PyIndex_AsSsize_t(index);
    if (likely(key_value != -1 || !(runerr = PyErr_Occurred()))) {
        return __Pyx_GetItemInt_Fast(obj, key_value, 0, 1, 1);
    }
    if (PyErr_GivenExceptionMatches(runerr, PyExc_OverflowError)) {
        PyErr_Clear();
        PyErr_Format(PyExc_IndexError, "cannot fit '%.200s' into an index-sized integer", Py_TYPE(index)->tp_name);
    }
    return NULL;
}
static PyObject *__Pyx_PyObject_GetItem(PyObject *obj, PyObject* key) {
    PyMappingMethods *m = Py_TYPE(obj)->tp_as_mapping;
    if (likely(m && m->mp_subscript)) {
        return m->mp_subscript(obj, key);
    }
    return __Pyx_PyObject_GetIndex(obj, key);
}
#endif

/* PyFunctionFastCall */
#if CYTHON_FAST_PYCALL
static PyObject* __Pyx_PyFunction_FastCallNoKw(PyCodeObject *co, PyObject **args, Py_ssize_t na,
                                               PyObject *globals) {
    PyFrameObject *f;
    PyThreadState *tstate = __Pyx_PyThreadState_Current;
    PyObject **fastlocals;
    Py_ssize_t i;
    PyObject *result;
    assert(globals != NULL);
    /* XXX Perhaps we should create a specialized
       PyFrame_New() that doesn't take locals, but does
       take builtins without sanity checking them.
       */
    assert(tstate != NULL);
    f = PyFrame_New(tstate, co, globals, NULL);
    if (f == NULL) {
        return NULL;
    }
    fastlocals = __Pyx_PyFrame_GetLocalsplus(f);
    for (i = 0; i < na; i++) {
        Py_INCREF(*args);
        fastlocals[i] = *args++;
    }
    result = PyEval_EvalFrameEx(f,0);
    ++tstate->recursion_depth;
    Py_DECREF(f);
    --tstate->recursion_depth;
    return result;
}
#if 1 || PY_VERSION_HEX < 0x030600B1
static PyObject *__Pyx_PyFunction_FastCallDict(PyObject *func, PyObject **args, Py_ssize_t nargs, PyObject *kwargs) {
    PyCodeObject *co = (PyCodeObject *)PyFunction_GET_CODE(func);
    PyObject *globals = PyFunction_GET_GLOBALS(func);
    PyObject *argdefs = PyFunction_GET_DEFAULTS(func);
    PyObject *closure;
#if PY_MAJOR_VERSION >= 3
    PyObject *kwdefs;
#endif
    PyObject *kwtuple, **k;
    PyObject **d;
    Py_ssize_t nd;
    Py_ssize_t nk;
    PyObject *result;
    assert(kwargs == NULL || PyDict_Check(kwargs));
    nk = kwargs ? PyDict_Size(kwargs) : 0;
    if (Py_EnterRecursiveCall((char*)" while calling a Python object")) {
        return NULL;
    }
    if (
#if PY_MAJOR_VERSION >= 3
            co->co_kwonlyargcount == 0 &&
#endif
            likely(kwargs == NULL || nk == 0) &&
            co->co_flags == (CO_OPTIMIZED | CO_NEWLOCALS | CO_NOFREE)) {
        if (argdefs == NULL && co->co_argcount == nargs) {
            result = __Pyx_PyFunction_FastCallNoKw(co, args, nargs, globals);
            goto done;
        }
        else if (nargs == 0 && argdefs != NULL
                 && co->co_argcount == Py_SIZE(argdefs)) {
            /* function called with no arguments, but all parameters have
               a default value: use default values as arguments .*/
            args = &PyTuple_GET_ITEM(argdefs, 0);
            result =__Pyx_PyFunction_FastCallNoKw(co, args, Py_SIZE(argdefs), globals);
            goto done;
        }
    }
    if (kwargs != NULL) {
        Py_ssize_t pos, i;
        kwtuple = PyTuple_New(2 * nk);
        if (kwtuple == NULL) {
            result = NULL;
            goto done;
        }
        k = &PyTuple_GET_ITEM(kwtuple, 0);
        pos = i = 0;
        while (PyDict_Next(kwargs, &pos, &k[i], &k[i+1])) {
            Py_INCREF(k[i]);
            Py_INCREF(k[i+1]);
            i += 2;
        }
        nk = i / 2;
    }
    else {
        kwtuple = NULL;
        k = NULL;
    }
    closure = PyFunction_GET_CLOSURE(func);
#if PY_MAJOR_VERSION >= 3
    kwdefs = PyFunction_GET_KW_DEFAULTS(func);
#endif
    if (argdefs != NULL) {
        d = &PyTuple_GET_ITEM(argdefs, 0);
        nd = Py_SIZE(argdefs);
    }
    else {
        d = NULL;
        nd = 0;
    }
#if PY_MAJOR_VERSION >= 3
    result = PyEval_EvalCodeEx((PyObject*)co, globals, (PyObject *)NULL,
                               args, (int)nargs,
                               k, (int)nk,
                               d, (int)nd, kwdefs, closure);
#else
    result = PyEval_EvalCodeEx(co, globals, (PyObject *)NULL,
                               args, (int)nargs,
                               k, (int)nk,
                               d, (int)nd, closure);
#endif
    Py_XDECREF(kwtuple);
done:
    Py_LeaveRecursiveCall();
    return result;
}
#endif
#endif

/* PyCFunctionFastCall */
#if CYTHON_FAST_PYCCALL
static CYTHON_INLINE PyObject * __Pyx_PyCFunction_FastCall(PyObject *func_obj, PyObject **args, Py_ssize_t nargs) {
    PyCFunctionObject *func = (PyCFunctionObject*)func_obj;
    PyCFunction meth = PyCFunction_GET_FUNCTION(func);
    PyObject *self = PyCFunction_GET_SELF(func);
    int flags = PyCFunction_GET_FLAGS(func);
    assert(PyCFunction_Check(func));
    assert(METH_FASTCALL == (flags & ~(METH_CLASS | METH_STATIC | METH_COEXIST | METH_KEYWORDS | METH_STACKLESS)));
    assert(nargs >= 0);
    assert(nargs == 0 || args != NULL);
    /* _PyCFunction_FastCallDict() must not be called with an exception set,
       because it may clear it (directly or indirectly) and so the
       caller loses its exception */
    assert(!PyErr_Occurred());
    if ((PY_VERSION_HEX < 0x030700A0) || unlikely(flags & METH_KEYWORDS)) {
        return (*((__Pyx_PyCFunctionFastWithKeywords)(void*)meth)) (self, args, nargs, NULL);
    } else {
        return (*((__Pyx_PyCFunctionFast)(void*)meth)) (self, args, nargs);
    }
}
#endif

/* PyObjectCall */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_Call(PyObject *func, PyObject *arg, PyObject *kw) {
    PyObject *result;
    ternaryfunc call = func->ob_type->tp_call;
    if (unlikely(!call))
        return PyObject_Call(func, arg, kw);
    if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object")))
        return NULL;
    result = (*call)(func, arg, kw);
    Py_LeaveRecursiveCall();
    if (unlikely(!result) && unlikely(!PyErr_Occurred())) {
        PyErr_SetString(
            PyExc_SystemError,
            "NULL result without error in PyObject_Call");
    }
    return result;
}
#endif

/* WriteUnraisableException */
static void __Pyx_WriteUnraisable(const char *name, CYTHON_UNUSED int clineno,
                                  CYTHON_UNUSED int lineno, CYTHON_UNUSED const char *filename,
                                  int full_traceback, CYTHON_UNUSED int nogil) {
    PyObject *old_exc, *old_val, *old_tb;
    PyObject *ctx;
    __Pyx_PyThreadState_declare
#ifdef WITH_THREAD
    PyGILState_STATE state;
    if (nogil)
        state = PyGILState_Ensure();
#ifdef _MSC_VER
    else state = (PyGILState_STATE)-1;
#endif
#endif
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&old_exc, &old_val, &old_tb);
    if (full_traceback) {
        Py_XINCREF(old_exc);
        Py_XINCREF(old_val);
        Py_XINCREF(old_tb);
        __Pyx_ErrRestore(old_exc, old_val, old_tb);
        PyErr_PrintEx(1);
    }
    #if PY_MAJOR_VERSION < 3
    ctx = PyString_FromString(name);
    #else
    ctx = PyUnicode_FromString(name);
    #endif
    __Pyx_ErrRestore(old_exc, old_val, old_tb);
    if (!ctx) {
        PyErr_WriteUnraisable(Py_None);
    } else {
        PyErr_WriteUnraisable(ctx);
        Py_DECREF(ctx);
    }
#ifdef WITH_THREAD
    if (nogil)
        PyGILState_Release(state);
#endif
}

/* None */
static CYTHON_INLINE long __Pyx_div_long(long a, long b) {
    long q = a / b;
    long r = a - q*b;
    q -= ((r != 0) & ((r ^ b) < 0));
    return q;
}

/* ExtTypeTest */
static CYTHON_INLINE int __Pyx_TypeTest(PyObject *obj, PyTypeObject *type) {
    if (unlikely(!type)) {
        PyErr_SetString(PyExc_SystemError, "Missing type object");
        return 0;
    }
    if (likely(__Pyx_TypeCheck(obj, type)))
        return 1;
    PyErr_Format(PyExc_TypeError, "Cannot convert %.200s to %.200s",
                 Py_TYPE(obj)->tp_name, type->tp_name);
    return 0;
}

/* DictGetItem */
#if PY_MAJOR_VERSION >= 3 && !CYTHON_COMPILING_IN_PYPY
static PyObject *__Pyx_PyDict_GetItem(PyObject *d, PyObject* key) {
    PyObject *value;
    value = PyDict_GetItemWithError(d, key);
    if (unlikely(!value)) {
        if (!PyErr_Occurred()) {
            if (unlikely(PyTuple_Check(key))) {
                PyObject* args = PyTuple_Pack(1, key);
                if (likely(args)) {
                    PyErr_SetObject(PyExc_KeyError, args);
                    Py_DECREF(args);
                }
            } else {
                PyErr_SetObject(PyExc_KeyError, key);
            }
        }
        return NULL;
    }
    Py_INCREF(value);
    return value;
}
#endif

/* SetItemInt */
static int __Pyx_SetItemInt_Generic(PyObject *o, PyObject *j, PyObject *v) {
    int r;
    if (!j) return -1;
    r = PyObject_SetItem(o, j, v);
    Py_DECREF(j);
    return r;
}
static CYTHON_INLINE int __Pyx_SetItemInt_Fast(PyObject *o, Py_ssize_t i, PyObject *v, int is_list,
                                               CYTHON_NCP_UNUSED int wraparound, CYTHON_NCP_UNUSED int boundscheck) {
#if CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS && CYTHON_USE_TYPE_SLOTS
    if (is_list || PyList_CheckExact(o)) {
        Py_ssize_t n = (!wraparound) ? i : ((likely(i >= 0)) ? i : i + PyList_GET_SIZE(o));
        if ((!boundscheck) || likely(__Pyx_is_valid_index(n, PyList_GET_SIZE(o)))) {
            PyObject* old = PyList_GET_ITEM(o, n);
            Py_INCREF(v);
            PyList_SET_ITEM(o, n, v);
            Py_DECREF(old);
            return 1;
        }
    } else {
        PySequenceMethods *m = Py_TYPE(o)->tp_as_sequence;
        if (likely(m && m->sq_ass_item)) {
            if (wraparound && unlikely(i < 0) && likely(m->sq_length)) {
                Py_ssize_t l = m->sq_length(o);
                if (likely(l >= 0)) {
                    i += l;
                } else {
                    if (!PyErr_ExceptionMatches(PyExc_OverflowError))
                        return -1;
                    PyErr_Clear();
                }
            }
            return m->sq_ass_item(o, i, v);
        }
    }
#else
#if CYTHON_COMPILING_IN_PYPY
    if (is_list || (PySequence_Check(o) && !PyDict_Check(o)))
#else
    if (is_list || PySequence_Check(o))
#endif
    {
        return PySequence_SetItem(o, i, v);
    }
#endif
    return __Pyx_SetItemInt_Generic(o, PyInt_FromSsize_t(i), v);
}

/* PyObjectCallMethO */
#if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallMethO(PyObject *func, PyObject *arg) {
    PyObject *self, *result;
    PyCFunction cfunc;
    cfunc = PyCFunction_GET_FUNCTION(func);
    self = PyCFunction_GET_SELF(func);
    if (unlikely(Py_EnterRecursiveCall((char*)" while calling a Python object")))
        return NULL;
    result = cfunc(self, arg);
    Py_LeaveRecursiveCall();
    if (unlikely(!result) && unlikely(!PyErr_Occurred())) {
        PyErr_SetString(
            PyExc_SystemError,
            "NULL result without error in PyObject_Call");
    }
    return result;
}
#endif

/* PyObjectCallOneArg */
#if CYTHON_COMPILING_IN_CPYTHON
static PyObject* __Pyx__PyObject_CallOneArg(PyObject *func, PyObject *arg) {
    PyObject *result;
    PyObject *args = PyTuple_New(1);
    if (unlikely(!args)) return NULL;
    Py_INCREF(arg);
    PyTuple_SET_ITEM(args, 0, arg);
    result = __Pyx_PyObject_Call(func, args, NULL);
    Py_DECREF(args);
    return result;
}
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallOneArg(PyObject *func, PyObject *arg) {
#if CYTHON_FAST_PYCALL
    if (PyFunction_Check(func)) {
        return __Pyx_PyFunction_FastCall(func, &arg, 1);
    }
#endif
    if (likely(PyCFunction_Check(func))) {
        if (likely(PyCFunction_GET_FLAGS(func) & METH_O)) {
            return __Pyx_PyObject_CallMethO(func, arg);
#if CYTHON_FAST_PYCCALL
        } else if (PyCFunction_GET_FLAGS(func) & METH_FASTCALL) {
            return __Pyx_PyCFunction_FastCall(func, &arg, 1);
#endif
        }
    }
    return __Pyx__PyObject_CallOneArg(func, arg);
}
#else
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallOneArg(PyObject *func, PyObject *arg) {
    PyObject *result;
    PyObject *args = PyTuple_Pack(1, arg);
    if (unlikely(!args)) return NULL;
    result = __Pyx_PyObject_Call(func, args, NULL);
    Py_DECREF(args);
    return result;
}
#endif

/* PyObjectCall2Args */
static CYTHON_UNUSED PyObject* __Pyx_PyObject_Call2Args(PyObject* function, PyObject* arg1, PyObject* arg2) {
    PyObject *args, *result = NULL;
    #if CYTHON_FAST_PYCALL
    if (PyFunction_Check(function)) {
        PyObject *args[2] = {arg1, arg2};
        return __Pyx_PyFunction_FastCall(function, args, 2);
    }
    #endif
    #if CYTHON_FAST_PYCCALL
    if (__Pyx_PyFastCFunction_Check(function)) {
        PyObject *args[2] = {arg1, arg2};
        return __Pyx_PyCFunction_FastCall(function, args, 2);
    }
    #endif
    args = PyTuple_New(2);
    if (unlikely(!args)) goto done;
    Py_INCREF(arg1);
    PyTuple_SET_ITEM(args, 0, arg1);
    Py_INCREF(arg2);
    PyTuple_SET_ITEM(args, 1, arg2);
    Py_INCREF(function);
    result = __Pyx_PyObject_Call(function, args, NULL);
    Py_DECREF(args);
    Py_DECREF(function);
done:
    return result;
}

/* IsLittleEndian */
static CYTHON_INLINE int __Pyx_Is_Little_Endian(void)
{
  union {
    uint32_t u32;
    uint8_t u8[4];
  } S;
  S.u32 = 0x01020304;
  return S.u8[0] == 4;
}

/* BufferFormatCheck */
static void __Pyx_BufFmt_Init(__Pyx_BufFmt_Context* ctx,
                              __Pyx_BufFmt_StackElem* stack,
                              __Pyx_TypeInfo* type) {
  stack[0].field = &ctx->root;
  stack[0].parent_offset = 0;
  ctx->root.type = type;
  ctx->root.name = "buffer dtype";
  ctx->root.offset = 0;
  ctx->head = stack;
  ctx->head->field = &ctx->root;
  ctx->fmt_offset = 0;
  ctx->head->parent_offset = 0;
  ctx->new_packmode = '@';
  ctx->enc_packmode = '@';
  ctx->new_count = 1;
  ctx->enc_count = 0;
  ctx->enc_type = 0;
  ctx->is_complex = 0;
  ctx->is_valid_array = 0;
  ctx->struct_alignment = 0;
  while (type->typegroup == 'S') {
    ++ctx->head;
    ctx->head->field = type->fields;
    ctx->head->parent_offset = 0;
    type = type->fields->type;
  }
}
static int __Pyx_BufFmt_ParseNumber(const char** ts) {
    int count;
    const char* t = *ts;
    if (*t < '0' || *t > '9') {
      return -1;
    } else {
        count = *t++ - '0';
        while (*t >= '0' && *t <= '9') {
            count *= 10;
            count += *t++ - '0';
        }
    }
    *ts = t;
    return count;
}
static int __Pyx_BufFmt_ExpectNumber(const char **ts) {
    int number = __Pyx_BufFmt_ParseNumber(ts);
    if (number == -1)
        PyErr_Format(PyExc_ValueError,\
                     "Does not understand character buffer dtype format string ('%c')", **ts);
    return number;
}
static void __Pyx_BufFmt_RaiseUnexpectedChar(char ch) {
  PyErr_Format(PyExc_ValueError,
               "Unexpected format string character: '%c'", ch);
}
static const char* __Pyx_BufFmt_DescribeTypeChar(char ch, int is_complex) {
  switch (ch) {
    case '?': return "'bool'";
    case 'c': return "'char'";
    case 'b': return "'signed char'";
    case 'B': return "'unsigned char'";
    case 'h': return "'short'";
    case 'H': return "'unsigned short'";
    case 'i': return "'int'";
    case 'I': return "'unsigned int'";
    case 'l': return "'long'";
    case 'L': return "'unsigned long'";
    case 'q': return "'long long'";
    case 'Q': return "'unsigned long long'";
    case 'f': return (is_complex ? "'complex float'" : "'float'");
    case 'd': return (is_complex ? "'complex double'" : "'double'");
    case 'g': return (is_complex ? "'complex long double'" : "'long double'");
    case 'T': return "a struct";
    case 'O': return "Python object";
    case 'P': return "a pointer";
    case 's': case 'p': return "a string";
    case 0: return "end";
    default: return "unparseable format string";
  }
}
static size_t __Pyx_BufFmt_TypeCharToStandardSize(char ch, int is_complex) {
  switch (ch) {
    case '?': case 'c': case 'b': case 'B': case 's': case 'p': return 1;
    case 'h': case 'H': return 2;
    case 'i': case 'I': case 'l': case 'L': return 4;
    case 'q': case 'Q': return 8;
    case 'f': return (is_complex ? 8 : 4);
    case 'd': return (is_complex ? 16 : 8);
    case 'g': {
      PyErr_SetString(PyExc_ValueError, "Python does not define a standard format string size for long double ('g')..");
      return 0;
    }
    case 'O': case 'P': return sizeof(void*);
    default:
      __Pyx_BufFmt_RaiseUnexpectedChar(ch);
      return 0;
    }
}
static size_t __Pyx_BufFmt_TypeCharToNativeSize(char ch, int is_complex) {
  switch (ch) {
    case '?': case 'c': case 'b': case 'B': case 's': case 'p': return 1;
    case 'h': case 'H': return sizeof(short);
    case 'i': case 'I': return sizeof(int);
    case 'l': case 'L': return sizeof(long);
    #ifdef HAVE_LONG_LONG
    case 'q': case 'Q': return sizeof(PY_LONG_LONG);
    #endif
    case 'f': return sizeof(float) * (is_complex ? 2 : 1);
    case 'd': return sizeof(double) * (is_complex ? 2 : 1);
    case 'g': return sizeof(long double) * (is_complex ? 2 : 1);
    case 'O': case 'P': return sizeof(void*);
    default: {
      __Pyx_BufFmt_RaiseUnexpectedChar(ch);
      return 0;
    }
  }
}
typedef struct { char c; short x; } __Pyx_st_short;
typedef struct { char c; int x; } __Pyx_st_int;
typedef struct { char c; long x; } __Pyx_st_long;
typedef struct { char c; float x; } __Pyx_st_float;
typedef struct { char c; double x; } __Pyx_st_double;
typedef struct { char c; long double x; } __Pyx_st_longdouble;
typedef struct { char c; void *x; } __Pyx_st_void_p;
#ifdef HAVE_LONG_LONG
typedef struct { char c; PY_LONG_LONG x; } __Pyx_st_longlong;
#endif
static size_t __Pyx_BufFmt_TypeCharToAlignment(char ch, CYTHON_UNUSED int is_complex) {
  switch (ch) {
    case '?': case 'c': case 'b': case 'B': case 's': case 'p': return 1;
    case 'h': case 'H': return sizeof(__Pyx_st_short) - sizeof(short);
    case 'i': case 'I': return sizeof(__Pyx_st_int) - sizeof(int);
    case 'l': case 'L': return sizeof(__Pyx_st_long) - sizeof(long);
#ifdef HAVE_LONG_LONG
    case 'q': case 'Q': return sizeof(__Pyx_st_longlong) - sizeof(PY_LONG_LONG);
#endif
    case 'f': return sizeof(__Pyx_st_float) - sizeof(float);
    case 'd': return sizeof(__Pyx_st_double) - sizeof(double);
    case 'g': return sizeof(__Pyx_st_longdouble) - sizeof(long double);
    case 'P': case 'O': return sizeof(__Pyx_st_void_p) - sizeof(void*);
    default:
      __Pyx_BufFmt_RaiseUnexpectedChar(ch);
      return 0;
    }
}
/* These are for computing the padding at the end of the struct to align
   on the first member of the struct. This will probably the same as above,
   but we don't have any guarantees.
 */
typedef struct { short x; char c; } __Pyx_pad_short;
typedef struct { int x; char c; } __Pyx_pad_int;
typedef struct { long x; char c; } __Pyx_pad_long;
typedef struct { float x; char c; } __Pyx_pad_float;
typedef struct { double x; char c; } __Pyx_pad_double;
typedef struct { long double x; char c; } __Pyx_pad_longdouble;
typedef struct { void *x; char c; } __Pyx_pad_void_p;
#ifdef HAVE_LONG_LONG
typedef struct { PY_LONG_LONG x; char c; } __Pyx_pad_longlong;
#endif
static size_t __Pyx_BufFmt_TypeCharToPadding(char ch, CYTHON_UNUSED int is_complex) {
  switch (ch) {
    case '?': case 'c': case 'b': case 'B': case 's': case 'p': return 1;
    case 'h': case 'H': return sizeof(__Pyx_pad_short) - sizeof(short);
    case 'i': case 'I': return sizeof(__Pyx_pad_int) - sizeof(int);
    case 'l': case 'L': return sizeof(__Pyx_pad_long) - sizeof(long);
#ifdef HAVE_LONG_LONG
    case 'q': case 'Q': return sizeof(__Pyx_pad_longlong) - sizeof(PY_LONG_LONG);
#endif
    case 'f': return sizeof(__Pyx_pad_float) - sizeof(float);
    case 'd': return sizeof(__Pyx_pad_double) - sizeof(double);
    case 'g': return sizeof(__Pyx_pad_longdouble) - sizeof(long double);
    case 'P': case 'O': return sizeof(__Pyx_pad_void_p) - sizeof(void*);
    default:
      __Pyx_BufFmt_RaiseUnexpectedChar(ch);
      return 0;
    }
}
static char __Pyx_BufFmt_TypeCharToGroup(char ch, int is_complex) {
  switch (ch) {
    case 'c':
        return 'H';
    case 'b': case 'h': case 'i':
    case 'l': case 'q': case 's': case 'p':
        return 'I';
    case '?': case 'B': case 'H': case 'I': case 'L': case 'Q':
        return 'U';
    case 'f': case 'd': case 'g':
        return (is_complex ? 'C' : 'R');
    case 'O':
        return 'O';
    case 'P':
        return 'P';
    default: {
      __Pyx_BufFmt_RaiseUnexpectedChar(ch);
      return 0;
    }
  }
}
static void __Pyx_BufFmt_RaiseExpected(__Pyx_BufFmt_Context* ctx) {
  if (ctx->head == NULL || ctx->head->field == &ctx->root) {
    const char* expected;
    const char* quote;
    if (ctx->head == NULL) {
      expected = "end";
      quote = "";
    } else {
      expected = ctx->head->field->type->name;
      quote = "'";
    }
    PyErr_Format(PyExc_ValueError,
                 "Buffer dtype mismatch, expected %s%s%s but got %s",
                 quote, expected, quote,
                 __Pyx_BufFmt_DescribeTypeChar(ctx->enc_type, ctx->is_complex));
  } else {
    __Pyx_StructField* field = ctx->head->field;
    __Pyx_StructField* parent = (ctx->head - 1)->field;
    PyErr_Format(PyExc_ValueError,
                 "Buffer dtype mismatch, expected '%s' but got %s in '%s.%s'",
                 field->type->name, __Pyx_BufFmt_DescribeTypeChar(ctx->enc_type, ctx->is_complex),
                 parent->type->name, field->name);
  }
}
static int __Pyx_BufFmt_ProcessTypeChunk(__Pyx_BufFmt_Context* ctx) {
  char group;
  size_t size, offset, arraysize = 1;
  if (ctx->enc_type == 0) return 0;
  if (ctx->head->field->type->arraysize[0]) {
    int i, ndim = 0;
    if (ctx->enc_type == 's' || ctx->enc_type == 'p') {
        ctx->is_valid_array = ctx->head->field->type->ndim == 1;
        ndim = 1;
        if (ctx->enc_count != ctx->head->field->type->arraysize[0]) {
            PyErr_Format(PyExc_ValueError,
                         "Expected a dimension of size %zu, got %zu",
                         ctx->head->field->type->arraysize[0], ctx->enc_count);
            return -1;
        }
    }
    if (!ctx->is_valid_array) {
      PyErr_Format(PyExc_ValueError, "Expected %d dimensions, got %d",
                   ctx->head->field->type->ndim, ndim);
      return -1;
    }
    for (i = 0; i < ctx->head->field->type->ndim; i++) {
      arraysize *= ctx->head->field->type->arraysize[i];
    }
    ctx->is_valid_array = 0;
    ctx->enc_count = 1;
  }
  group = __Pyx_BufFmt_TypeCharToGroup(ctx->enc_type, ctx->is_complex);
  do {
    __Pyx_StructField* field = ctx->head->field;
    __Pyx_TypeInfo* type = field->type;
    if (ctx->enc_packmode == '@' || ctx->enc_packmode == '^') {
      size = __Pyx_BufFmt_TypeCharToNativeSize(ctx->enc_type, ctx->is_complex);
    } else {
      size = __Pyx_BufFmt_TypeCharToStandardSize(ctx->enc_type, ctx->is_complex);
    }
    if (ctx->enc_packmode == '@') {
      size_t align_at = __Pyx_BufFmt_TypeCharToAlignment(ctx->enc_type, ctx->is_complex);
      size_t align_mod_offset;
      if (align_at == 0) return -1;
      align_mod_offset = ctx->fmt_offset % align_at;
      if (align_mod_offset > 0) ctx->fmt_offset += align_at - align_mod_offset;
      if (ctx->struct_alignment == 0)
          ctx->struct_alignment = __Pyx_BufFmt_TypeCharToPadding(ctx->enc_type,
                                                                 ctx->is_complex);
    }
    if (type->size != size || type->typegroup != group) {
      if (type->typegroup == 'C' && type->fields != NULL) {
        size_t parent_offset = ctx->head->parent_offset + field->offset;
        ++ctx->head;
        ctx->head->field = type->fields;
        ctx->head->parent_offset = parent_offset;
        continue;
      }
      if ((type->typegroup == 'H' || group == 'H') && type->size == size) {
      } else {
          __Pyx_BufFmt_RaiseExpected(ctx);
          return -1;
      }
    }
    offset = ctx->head->parent_offset + field->offset;
    if (ctx->fmt_offset != offset) {
      PyErr_Format(PyExc_ValueError,
                   "Buffer dtype mismatch; next field is at offset %" CYTHON_FORMAT_SSIZE_T "d but %" CYTHON_FORMAT_SSIZE_T "d expected",
                   (Py_ssize_t)ctx->fmt_offset, (Py_ssize_t)offset);
      return -1;
    }
    ctx->fmt_offset += size;
    if (arraysize)
      ctx->fmt_offset += (arraysize - 1) * size;
    --ctx->enc_count;
    while (1) {
      if (field == &ctx->root) {
        ctx->head = NULL;
        if (ctx->enc_count != 0) {
          __Pyx_BufFmt_RaiseExpected(ctx);
          return -1;
        }
        break;
      }
      ctx->head->field = ++field;
      if (field->type == NULL) {
        --ctx->head;
        field = ctx->head->field;
        continue;
      } else if (field->type->typegroup == 'S') {
        size_t parent_offset = ctx->head->parent_offset + field->offset;
        if (field->type->fields->type == NULL) continue;
        field = field->type->fields;
        ++ctx->head;
        ctx->head->field = field;
        ctx->head->parent_offset = parent_offset;
        break;
      } else {
        break;
      }
    }
  } while (ctx->enc_count);
  ctx->enc_type = 0;
  ctx->is_complex = 0;
  return 0;
}
static PyObject *
__pyx_buffmt_parse_array(__Pyx_BufFmt_Context* ctx, const char** tsp)
{
    const char *ts = *tsp;
    int i = 0, number;
    int ndim = ctx->head->field->type->ndim;
;
    ++ts;
    if (ctx->new_count != 1) {
        PyErr_SetString(PyExc_ValueError,
                        "Cannot handle repeated arrays in format string");
        return NULL;
    }
    if (__Pyx_BufFmt_ProcessTypeChunk(ctx) == -1) return NULL;
    while (*ts && *ts != ')') {
        switch (*ts) {
            case ' ': case '\f': case '\r': case '\n': case '\t': case '\v':  continue;
            default:  break;
        }
        number = __Pyx_BufFmt_ExpectNumber(&ts);
        if (number == -1) return NULL;
        if (i < ndim && (size_t) number != ctx->head->field->type->arraysize[i])
            return PyErr_Format(PyExc_ValueError,
                        "Expected a dimension of size %zu, got %d",
                        ctx->head->field->type->arraysize[i], number);
        if (*ts != ',' && *ts != ')')
            return PyErr_Format(PyExc_ValueError,
                                "Expected a comma in format string, got '%c'", *ts);
        if (*ts == ',') ts++;
        i++;
    }
    if (i != ndim)
        return PyErr_Format(PyExc_ValueError, "Expected %d dimension(s), got %d",
                            ctx->head->field->type->ndim, i);
    if (!*ts) {
        PyErr_SetString(PyExc_ValueError,
                        "Unexpected end of format string, expected ')'");
        return NULL;
    }
    ctx->is_valid_array = 1;
    ctx->new_count = 1;
    *tsp = ++ts;
    return Py_None;
}
static const char* __Pyx_BufFmt_CheckString(__Pyx_BufFmt_Context* ctx, const char* ts) {
  int got_Z = 0;
  while (1) {
    switch(*ts) {
      case 0:
        if (ctx->enc_type != 0 && ctx->head == NULL) {
          __Pyx_BufFmt_RaiseExpected(ctx);
          return NULL;
        }
        if (__Pyx_BufFmt_ProcessTypeChunk(ctx) == -1) return NULL;
        if (ctx->head != NULL) {
          __Pyx_BufFmt_RaiseExpected(ctx);
          return NULL;
        }
        return ts;
      case ' ':
      case '\r':
      case '\n':
        ++ts;
        break;
      case '<':
        if (!__Pyx_Is_Little_Endian()) {
          PyErr_SetString(PyExc_ValueError, "Little-endian buffer not supported on big-endian compiler");
          return NULL;
        }
        ctx->new_packmode = '=';
        ++ts;
        break;
      case '>':
      case '!':
        if (__Pyx_Is_Little_Endian()) {
          PyErr_SetString(PyExc_ValueError, "Big-endian buffer not supported on little-endian compiler");
          return NULL;
        }
        ctx->new_packmode = '=';
        ++ts;
        break;
      case '=':
      case '@':
      case '^':
        ctx->new_packmode = *ts++;
        break;
      case 'T':
        {
          const char* ts_after_sub;
          size_t i, struct_count = ctx->new_count;
          size_t struct_alignment = ctx->struct_alignment;
          ctx->new_count = 1;
          ++ts;
          if (*ts != '{') {
            PyErr_SetString(PyExc_ValueError, "Buffer acquisition: Expected '{' after 'T'");
            return NULL;
          }
          if (__Pyx_BufFmt_ProcessTypeChunk(ctx) == -1) return NULL;
          ctx->enc_type = 0;
          ctx->enc_count = 0;
          ctx->struct_alignment = 0;
          ++ts;
          ts_after_sub = ts;
          for (i = 0; i != struct_count; ++i) {
            ts_after_sub = __Pyx_BufFmt_CheckString(ctx, ts);
            if (!ts_after_sub) return NULL;
          }
          ts = ts_after_sub;
          if (struct_alignment) ctx->struct_alignment = struct_alignment;
        }
        break;
      case '}':
        {
          size_t alignment = ctx->struct_alignment;
          ++ts;
          if (__Pyx_BufFmt_ProcessTypeChunk(ctx) == -1) return NULL;
          ctx->enc_type = 0;
          if (alignment && ctx->fmt_offset % alignment) {
            ctx->fmt_offset += alignment - (ctx->fmt_offset % alignment);
          }
        }
        return ts;
      case 'x':
        if (__Pyx_BufFmt_ProcessTypeChunk(ctx) == -1) return NULL;
        ctx->fmt_offset += ctx->new_count;
        ctx->new_count = 1;
        ctx->enc_count = 0;
        ctx->enc_type = 0;
        ctx->enc_packmode = ctx->new_packmode;
        ++ts;
        break;
      case 'Z':
        got_Z = 1;
        ++ts;
        if (*ts != 'f' && *ts != 'd' && *ts != 'g') {
          __Pyx_BufFmt_RaiseUnexpectedChar('Z');
          return NULL;
        }
        CYTHON_FALLTHROUGH;
      case '?': case 'c': case 'b': case 'B': case 'h': case 'H': case 'i': case 'I':
      case 'l': case 'L': case 'q': case 'Q':
      case 'f': case 'd': case 'g':
      case 'O': case 'p':
        if (ctx->enc_type == *ts && got_Z == ctx->is_complex &&
            ctx->enc_packmode == ctx->new_packmode) {
          ctx->enc_count += ctx->new_count;
          ctx->new_count = 1;
          got_Z = 0;
          ++ts;
          break;
        }
        CYTHON_FALLTHROUGH;
      case 's':
        if (__Pyx_BufFmt_ProcessTypeChunk(ctx) == -1) return NULL;
        ctx->enc_count = ctx->new_count;
        ctx->enc_packmode = ctx->new_packmode;
        ctx->enc_type = *ts;
        ctx->is_complex = got_Z;
        ++ts;
        ctx->new_count = 1;
        got_Z = 0;
        break;
      case ':':
        ++ts;
        while(*ts != ':') ++ts;
        ++ts;
        break;
      case '(':
        if (!__pyx_buffmt_parse_array(ctx, &ts)) return NULL;
        break;
      default:
        {
          int number = __Pyx_BufFmt_ExpectNumber(&ts);
          if (number == -1) return NULL;
          ctx->new_count = (size_t)number;
        }
    }
  }
}

/* BufferGetAndValidate */
  static CYTHON_INLINE void __Pyx_SafeReleaseBuffer(Py_buffer* info) {
  if (unlikely(info->buf == NULL)) return;
  if (info->suboffsets == __Pyx_minusones) info->suboffsets = NULL;
  __Pyx_ReleaseBuffer(info);
}
static void __Pyx_ZeroBuffer(Py_buffer* buf) {
  buf->buf = NULL;
  buf->obj = NULL;
  buf->strides = __Pyx_zeros;
  buf->shape = __Pyx_zeros;
  buf->suboffsets = __Pyx_minusones;
}
static int __Pyx__GetBufferAndValidate(
        Py_buffer* buf, PyObject* obj,  __Pyx_TypeInfo* dtype, int flags,
        int nd, int cast, __Pyx_BufFmt_StackElem* stack)
{
  buf->buf = NULL;
  if (unlikely(__Pyx_GetBuffer(obj, buf, flags) == -1)) {
    __Pyx_ZeroBuffer(buf);
    return -1;
  }
  if (unlikely(buf->ndim != nd)) {
    PyErr_Format(PyExc_ValueError,
                 "Buffer has wrong number of dimensions (expected %d, got %d)",
                 nd, buf->ndim);
    goto fail;
  }
  if (!cast) {
    __Pyx_BufFmt_Context ctx;
    __Pyx_BufFmt_Init(&ctx, stack, dtype);
    if (!__Pyx_BufFmt_CheckString(&ctx, buf->format)) goto fail;
  }
  if (unlikely((size_t)buf->itemsize != dtype->size)) {
    PyErr_Format(PyExc_ValueError,
      "Item size of buffer (%" CYTHON_FORMAT_SSIZE_T "d byte%s) does not match size of '%s' (%" CYTHON_FORMAT_SSIZE_T "d byte%s)",
      buf->itemsize, (buf->itemsize > 1) ? "s" : "",
      dtype->name, (Py_ssize_t)dtype->size, (dtype->size > 1) ? "s" : "");
    goto fail;
  }
  if (buf->suboffsets == NULL) buf->suboffsets = __Pyx_minusones;
  return 0;
fail:;
  __Pyx_SafeReleaseBuffer(buf);
  return -1;
}

/* PyIntBinop */
  #if !CYTHON_COMPILING_IN_PYPY
#if PY_MAJOR_VERSION < 3 || CYTHON_USE_PYLONG_INTERNALS
#define __Pyx_PyInt_TrueDivideObjC_ZeroDivisionError(operand)\
    if (unlikely(zerodivision_check && ((operand) == 0))) {\
        PyErr_SetString(PyExc_ZeroDivisionError, "integer division by zero");\
        return NULL;\
    }
#endif
static PyObject* __Pyx_PyInt_TrueDivideObjC(PyObject *op1, PyObject *op2, CYTHON_UNUSED long intval, int inplace, int zerodivision_check) {
    (void)inplace;
    (void)zerodivision_check;
    #if PY_MAJOR_VERSION < 3
    if (likely(PyInt_CheckExact(op1))) {
        const long b = intval;
        long a = PyInt_AS_LONG(op1);
            __Pyx_PyInt_TrueDivideObjC_ZeroDivisionError(b)
            if (8 * sizeof(long) <= 53 || likely(labs(a) <= ((PY_LONG_LONG)1 << 53))) {
                return PyFloat_FromDouble((double)a / (double)b);
            }
            return PyInt_Type.tp_as_number->nb_true_divide(op1, op2);
    }
    #endif
    #if CYTHON_USE_PYLONG_INTERNALS
    if (likely(PyLong_CheckExact(op1))) {
        const long b = intval;
        long a, x;
        const digit* digits = ((PyLongObject*)op1)->ob_digit;
        const Py_ssize_t size = Py_SIZE(op1);
        if (likely(__Pyx_sst_abs(size) <= 1)) {
            a = likely(size) ? digits[0] : 0;
            if (size == -1) a = -a;
        } else {
            switch (size) {
                case -2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT && 1 * PyLong_SHIFT < 53) {
                        a = -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    }
                    CYTHON_FALLTHROUGH;
                case 2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT && 1 * PyLong_SHIFT < 53) {
                        a = (long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    }
                    CYTHON_FALLTHROUGH;
                case -3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT && 2 * PyLong_SHIFT < 53) {
                        a = -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    }
                    CYTHON_FALLTHROUGH;
                case 3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT && 2 * PyLong_SHIFT < 53) {
                        a = (long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    }
                    CYTHON_FALLTHROUGH;
                case -4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT && 3 * PyLong_SHIFT < 53) {
                        a = -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    }
                    CYTHON_FALLTHROUGH;
                case 4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT && 3 * PyLong_SHIFT < 53) {
                        a = (long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
                    }
                    CYTHON_FALLTHROUGH;
                default: return PyLong_Type.tp_as_number->nb_true_divide(op1, op2);
            }
        }
                __Pyx_PyInt_TrueDivideObjC_ZeroDivisionError(b)
                if ((8 * sizeof(long) <= 53 || likely(labs(a) <= ((PY_LONG_LONG)1 << 53)))
                        || __Pyx_sst_abs(size) <= 52 / PyLong_SHIFT) {
                    return PyFloat_FromDouble((double)a / (double)b);
                }
                return PyLong_Type.tp_as_number->nb_true_divide(op1, op2);
            return PyLong_FromLong(x);
        
    }
    #endif
    if (PyFloat_CheckExact(op1)) {
        const long b = intval;
        double a = PyFloat_AS_DOUBLE(op1);
            double result;
            if (unlikely(zerodivision_check && b == 0)) {
                PyErr_SetString(PyExc_ZeroDivisionError, "float division by zero");
                return NULL;
            }
            PyFPE_START_PROTECT("divide", return NULL)
            result = ((double)a) / (double)b;
            PyFPE_END_PROTECT(result)
            return PyFloat_FromDouble(result);
    }
    return (inplace ? PyNumber_InPlaceTrueDivide : PyNumber_TrueDivide)(op1, op2);
}
#endif

/* RaiseTooManyValuesToUnpack */
  static CYTHON_INLINE void __Pyx_RaiseTooManyValuesError(Py_ssize_t expected) {
    PyErr_Format(PyExc_ValueError,
                 "too many values to unpack (expected %" CYTHON_FORMAT_SSIZE_T "d)", expected);
}

/* RaiseNeedMoreValuesToUnpack */
  static CYTHON_INLINE void __Pyx_RaiseNeedMoreValuesError(Py_ssize_t index) {
    PyErr_Format(PyExc_ValueError,
                 "need more than %" CYTHON_FORMAT_SSIZE_T "d value%.1s to unpack",
                 index, (index == 1) ? "" : "s");
}

/* IterFinish */
  static CYTHON_INLINE int __Pyx_IterFinish(void) {
#if CYTHON_FAST_THREAD_STATE
    PyThreadState *tstate = __Pyx_PyThreadState_Current;
    PyObject* exc_type = tstate->curexc_type;
    if (unlikely(exc_type)) {
        if (likely(__Pyx_PyErr_GivenExceptionMatches(exc_type, PyExc_StopIteration))) {
            PyObject *exc_value, *exc_tb;
            exc_value = tstate->curexc_value;
            exc_tb = tstate->curexc_traceback;
            tstate->curexc_type = 0;
            tstate->curexc_value = 0;
            tstate->curexc_traceback = 0;
            Py_DECREF(exc_type);
            Py_XDECREF(exc_value);
            Py_XDECREF(exc_tb);
            return 0;
        } else {
            return -1;
        }
    }
    return 0;
#else
    if (unlikely(PyErr_Occurred())) {
        if (likely(PyErr_ExceptionMatches(PyExc_StopIteration))) {
            PyErr_Clear();
            return 0;
        } else {
            return -1;
        }
    }
    return 0;
#endif
}

/* UnpackItemEndCheck */
  static int __Pyx_IternextUnpackEndCheck(PyObject *retval, Py_ssize_t expected) {
    if (unlikely(retval)) {
        Py_DECREF(retval);
        __Pyx_RaiseTooManyValuesError(expected);
        return -1;
    } else {
        return __Pyx_IterFinish();
    }
    return 0;
}

/* BufferIndexError */
  static void __Pyx_RaiseBufferIndexError(int axis) {
  PyErr_Format(PyExc_IndexError,
     "Out of bounds on buffer access (axis %d)", axis);
}

/* SliceObject */
  static CYTHON_INLINE PyObject* __Pyx_PyObject_GetSlice(PyObject* obj,
        Py_ssize_t cstart, Py_ssize_t cstop,
        PyObject** _py_start, PyObject** _py_stop, PyObject** _py_slice,
        int has_cstart, int has_cstop, CYTHON_UNUSED int wraparound) {
#if CYTHON_USE_TYPE_SLOTS
    PyMappingMethods* mp;
#if PY_MAJOR_VERSION < 3
    PySequenceMethods* ms = Py_TYPE(obj)->tp_as_sequence;
    if (likely(ms && ms->sq_slice)) {
        if (!has_cstart) {
            if (_py_start && (*_py_start != Py_None)) {
                cstart = __Pyx_PyIndex_AsSsize_t(*_py_start);
                if ((cstart == (Py_ssize_t)-1) && PyErr_Occurred()) goto bad;
            } else
                cstart = 0;
        }
        if (!has_cstop) {
            if (_py_stop && (*_py_stop != Py_None)) {
                cstop = __Pyx_PyIndex_AsSsize_t(*_py_stop);
                if ((cstop == (Py_ssize_t)-1) && PyErr_Occurred()) goto bad;
            } else
                cstop = PY_SSIZE_T_MAX;
        }
        if (wraparound && unlikely((cstart < 0) | (cstop < 0)) && likely(ms->sq_length)) {
            Py_ssize_t l = ms->sq_length(obj);
            if (likely(l >= 0)) {
                if (cstop < 0) {
                    cstop += l;
                    if (cstop < 0) cstop = 0;
                }
                if (cstart < 0) {
                    cstart += l;
                    if (cstart < 0) cstart = 0;
                }
            } else {
                if (!PyErr_ExceptionMatches(PyExc_OverflowError))
                    goto bad;
                PyErr_Clear();
            }
        }
        return ms->sq_slice(obj, cstart, cstop);
    }
#endif
    mp = Py_TYPE(obj)->tp_as_mapping;
    if (likely(mp && mp->mp_subscript))
#endif
    {
        PyObject* result;
        PyObject *py_slice, *py_start, *py_stop;
        if (_py_slice) {
            py_slice = *_py_slice;
        } else {
            PyObject* owned_start = NULL;
            PyObject* owned_stop = NULL;
            if (_py_start) {
                py_start = *_py_start;
            } else {
                if (has_cstart) {
                    owned_start = py_start = PyInt_FromSsize_t(cstart);
                    if (unlikely(!py_start)) goto bad;
                } else
                    py_start = Py_None;
            }
            if (_py_stop) {
                py_stop = *_py_stop;
            } else {
                if (has_cstop) {
                    owned_stop = py_stop = PyInt_FromSsize_t(cstop);
                    if (unlikely(!py_stop)) {
                        Py_XDECREF(owned_start);
                        goto bad;
                    }
                } else
                    py_stop = Py_None;
            }
            py_slice = PySlice_New(py_start, py_stop, Py_None);
            Py_XDECREF(owned_start);
            Py_XDECREF(owned_stop);
            if (unlikely(!py_slice)) goto bad;
        }
#if CYTHON_USE_TYPE_SLOTS
        result = mp->mp_subscript(obj, py_slice);
#else
        result = PyObject_GetItem(obj, py_slice);
#endif
        if (!_py_slice) {
            Py_DECREF(py_slice);
        }
        return result;
    }
    PyErr_Format(PyExc_TypeError,
        "'%.200s' object is unsliceable", Py_TYPE(obj)->tp_name);
bad:
    return NULL;
}

/* RaiseArgTupleInvalid */
  static void __Pyx_RaiseArgtupleInvalid(
    const char* func_name,
    int exact,
    Py_ssize_t num_min,
    Py_ssize_t num_max,
    Py_ssize_t num_found)
{
    Py_ssize_t num_expected;
    const char *more_or_less;
    if (num_found < num_min) {
        num_expected = num_min;
        more_or_less = "at least";
    } else {
        num_expected = num_max;
        more_or_less = "at most";
    }
    if (exact) {
        more_or_less = "exactly";
    }
    PyErr_Format(PyExc_TypeError,
                 "%.200s() takes %.8s %" CYTHON_FORMAT_SSIZE_T "d positional argument%.1s (%" CYTHON_FORMAT_SSIZE_T "d given)",
                 func_name, more_or_less, num_expected,
                 (num_expected == 1) ? "" : "s", num_found);
}

/* RaiseDoubleKeywords */
  static void __Pyx_RaiseDoubleKeywordsError(
    const char* func_name,
    PyObject* kw_name)
{
    PyErr_Format(PyExc_TypeError,
        #if PY_MAJOR_VERSION >= 3
        "%s() got multiple values for keyword argument '%U'", func_name, kw_name);
        #else
        "%s() got multiple values for keyword argument '%s'", func_name,
        PyString_AsString(kw_name));
        #endif
}

/* ParseKeywords */
  static int __Pyx_ParseOptionalKeywords(
    PyObject *kwds,
    PyObject **argnames[],
    PyObject *kwds2,
    PyObject *values[],
    Py_ssize_t num_pos_args,
    const char* function_name)
{
    PyObject *key = 0, *value = 0;
    Py_ssize_t pos = 0;
    PyObject*** name;
    PyObject*** first_kw_arg = argnames + num_pos_args;
    while (PyDict_Next(kwds, &pos, &key, &value)) {
        name = first_kw_arg;
        while (*name && (**name != key)) name++;
        if (*name) {
            values[name-argnames] = value;
            continue;
        }
        name = first_kw_arg;
        #if PY_MAJOR_VERSION < 3
        if (likely(PyString_CheckExact(key)) || likely(PyString_Check(key))) {
            while (*name) {
                if ((CYTHON_COMPILING_IN_PYPY || PyString_GET_SIZE(**name) == PyString_GET_SIZE(key))
                        && _PyString_Eq(**name, key)) {
                    values[name-argnames] = value;
                    break;
                }
                name++;
            }
            if (*name) continue;
            else {
                PyObject*** argname = argnames;
                while (argname != first_kw_arg) {
                    if ((**argname == key) || (
                            (CYTHON_COMPILING_IN_PYPY || PyString_GET_SIZE(**argname) == PyString_GET_SIZE(key))
                             && _PyString_Eq(**argname, key))) {
                        goto arg_passed_twice;
                    }
                    argname++;
                }
            }
        } else
        #endif
        if (likely(PyUnicode_Check(key))) {
            while (*name) {
                int cmp = (**name == key) ? 0 :
                #if !CYTHON_COMPILING_IN_PYPY && PY_MAJOR_VERSION >= 3
                    (PyUnicode_GET_SIZE(**name) != PyUnicode_GET_SIZE(key)) ? 1 :
                #endif
                    PyUnicode_Compare(**name, key);
                if (cmp < 0 && unlikely(PyErr_Occurred())) goto bad;
                if (cmp == 0) {
                    values[name-argnames] = value;
                    break;
                }
                name++;
            }
            if (*name) continue;
            else {
                PyObject*** argname = argnames;
                while (argname != first_kw_arg) {
                    int cmp = (**argname == key) ? 0 :
                    #if !CYTHON_COMPILING_IN_PYPY && PY_MAJOR_VERSION >= 3
                        (PyUnicode_GET_SIZE(**argname) != PyUnicode_GET_SIZE(key)) ? 1 :
                    #endif
                        PyUnicode_Compare(**argname, key);
                    if (cmp < 0 && unlikely(PyErr_Occurred())) goto bad;
                    if (cmp == 0) goto arg_passed_twice;
                    argname++;
                }
            }
        } else
            goto invalid_keyword_type;
        if (kwds2) {
            if (unlikely(PyDict_SetItem(kwds2, key, value))) goto bad;
        } else {
            goto invalid_keyword;
        }
    }
    return 0;
arg_passed_twice:
    __Pyx_RaiseDoubleKeywordsError(function_name, key);
    goto bad;
invalid_keyword_type:
    PyErr_Format(PyExc_TypeError,
        "%.200s() keywords must be strings", function_name);
    goto bad;
invalid_keyword:
    PyErr_Format(PyExc_TypeError,
    #if PY_MAJOR_VERSION < 3
        "%.200s() got an unexpected keyword argument '%.200s'",
        function_name, PyString_AsString(key));
    #else
        "%s() got an unexpected keyword argument '%U'",
        function_name, key);
    #endif
bad:
    return -1;
}

/* ArgTypeTest */
  static int __Pyx__ArgTypeTest(PyObject *obj, PyTypeObject *type, const char *name, int exact)
{
    if (unlikely(!type)) {
        PyErr_SetString(PyExc_SystemError, "Missing type object");
        return 0;
    }
    else if (exact) {
        #if PY_MAJOR_VERSION == 2
        if ((type == &PyBaseString_Type) && likely(__Pyx_PyBaseString_CheckExact(obj))) return 1;
        #endif
    }
    else {
        if (likely(__Pyx_TypeCheck(obj, type))) return 1;
    }
    PyErr_Format(PyExc_TypeError,
        "Argument '%.200s' has incorrect type (expected %.200s, got %.200s)",
        name, type->tp_name, Py_TYPE(obj)->tp_name);
    return 0;
}

/* RaiseException */
  #if PY_MAJOR_VERSION < 3
static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb,
                        CYTHON_UNUSED PyObject *cause) {
    __Pyx_PyThreadState_declare
    Py_XINCREF(type);
    if (!value || value == Py_None)
        value = NULL;
    else
        Py_INCREF(value);
    if (!tb || tb == Py_None)
        tb = NULL;
    else {
        Py_INCREF(tb);
        if (!PyTraceBack_Check(tb)) {
            PyErr_SetString(PyExc_TypeError,
                "raise: arg 3 must be a traceback or None");
            goto raise_error;
        }
    }
    if (PyType_Check(type)) {
#if CYTHON_COMPILING_IN_PYPY
        if (!value) {
            Py_INCREF(Py_None);
            value = Py_None;
        }
#endif
        PyErr_NormalizeException(&type, &value, &tb);
    } else {
        if (value) {
            PyErr_SetString(PyExc_TypeError,
                "instance exception may not have a separate value");
            goto raise_error;
        }
        value = type;
        type = (PyObject*) Py_TYPE(type);
        Py_INCREF(type);
        if (!PyType_IsSubtype((PyTypeObject *)type, (PyTypeObject *)PyExc_BaseException)) {
            PyErr_SetString(PyExc_TypeError,
                "raise: exception class must be a subclass of BaseException");
            goto raise_error;
        }
    }
    __Pyx_PyThreadState_assign
    __Pyx_ErrRestore(type, value, tb);
    return;
raise_error:
    Py_XDECREF(value);
    Py_XDECREF(type);
    Py_XDECREF(tb);
    return;
}
#else
static void __Pyx_Raise(PyObject *type, PyObject *value, PyObject *tb, PyObject *cause) {
    PyObject* owned_instance = NULL;
    if (tb == Py_None) {
        tb = 0;
    } else if (tb && !PyTraceBack_Check(tb)) {
        PyErr_SetString(PyExc_TypeError,
            "raise: arg 3 must be a traceback or None");
        goto bad;
    }
    if (value == Py_None)
        value = 0;
    if (PyExceptionInstance_Check(type)) {
        if (value) {
            PyErr_SetString(PyExc_TypeError,
                "instance exception may not have a separate value");
            goto bad;
        }
        value = type;
        type = (PyObject*) Py_TYPE(value);
    } else if (PyExceptionClass_Check(type)) {
        PyObject *instance_class = NULL;
        if (value && PyExceptionInstance_Check(value)) {
            instance_class = (PyObject*) Py_TYPE(value);
            if (instance_class != type) {
                int is_subclass = PyObject_IsSubclass(instance_class, type);
                if (!is_subclass) {
                    instance_class = NULL;
                } else if (unlikely(is_subclass == -1)) {
                    goto bad;
                } else {
                    type = instance_class;
                }
            }
        }
        if (!instance_class) {
            PyObject *args;
            if (!value)
                args = PyTuple_New(0);
            else if (PyTuple_Check(value)) {
                Py_INCREF(value);
                args = value;
            } else
                args = PyTuple_Pack(1, value);
            if (!args)
                goto bad;
            owned_instance = PyObject_Call(type, args, NULL);
            Py_DECREF(args);
            if (!owned_instance)
                goto bad;
            value = owned_instance;
            if (!PyExceptionInstance_Check(value)) {
                PyErr_Format(PyExc_TypeError,
                             "calling %R should have returned an instance of "
                             "BaseException, not %R",
                             type, Py_TYPE(value));
                goto bad;
            }
        }
    } else {
        PyErr_SetString(PyExc_TypeError,
            "raise: exception class must be a subclass of BaseException");
        goto bad;
    }
    if (cause) {
        PyObject *fixed_cause;
        if (cause == Py_None) {
            fixed_cause = NULL;
        } else if (PyExceptionClass_Check(cause)) {
            fixed_cause = PyObject_CallObject(cause, NULL);
            if (fixed_cause == NULL)
                goto bad;
        } else if (PyExceptionInstance_Check(cause)) {
            fixed_cause = cause;
            Py_INCREF(fixed_cause);
        } else {
            PyErr_SetString(PyExc_TypeError,
                            "exception causes must derive from "
                            "BaseException");
            goto bad;
        }
        PyException_SetCause(value, fixed_cause);
    }
    PyErr_SetObject(type, value);
    if (tb) {
#if CYTHON_COMPILING_IN_PYPY
        PyObject *tmp_type, *tmp_value, *tmp_tb;
        PyErr_Fetch(&tmp_type, &tmp_value, &tmp_tb);
        Py_INCREF(tb);
        PyErr_Restore(tmp_type, tmp_value, tb);
        Py_XDECREF(tmp_tb);
#else
        PyThreadState *tstate = __Pyx_PyThreadState_Current;
        PyObject* tmp_tb = tstate->curexc_traceback;
        if (tb != tmp_tb) {
            Py_INCREF(tb);
            tstate->curexc_traceback = tb;
            Py_XDECREF(tmp_tb);
        }
#endif
    }
bad:
    Py_XDECREF(owned_instance);
    return;
}
#endif

/* PyObjectCallNoArg */
  #if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyObject_CallNoArg(PyObject *func) {
#if CYTHON_FAST_PYCALL
    if (PyFunction_Check(func)) {
        return __Pyx_PyFunction_FastCall(func, NULL, 0);
    }
#endif
#ifdef __Pyx_CyFunction_USED
    if (likely(PyCFunction_Check(func) || __Pyx_CyFunction_Check(func)))
#else
    if (likely(PyCFunction_Check(func)))
#endif
    {
        if (likely(PyCFunction_GET_FLAGS(func) & METH_NOARGS)) {
            return __Pyx_PyObject_CallMethO(func, NULL);
        }
    }
    return __Pyx_PyObject_Call(func, __pyx_empty_tuple, NULL);
}
#endif

/* UnpackUnboundCMethod */
  static int __Pyx_TryUnpackUnboundCMethod(__Pyx_CachedCFunction* target) {
    PyObject *method;
    method = __Pyx_PyObject_GetAttrStr(target->type, *target->method_name);
    if (unlikely(!method))
        return -1;
    target->method = method;
#if CYTHON_COMPILING_IN_CPYTHON
    #if PY_MAJOR_VERSION >= 3
    if (likely(__Pyx_TypeCheck(method, &PyMethodDescr_Type)))
    #endif
    {
        PyMethodDescrObject *descr = (PyMethodDescrObject*) method;
        target->func = descr->d_method->ml_meth;
        target->flag = descr->d_method->ml_flags & ~(METH_CLASS | METH_STATIC | METH_COEXIST | METH_STACKLESS);
    }
#endif
    return 0;
}

/* CallUnboundCMethod1 */
  #if CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_CallUnboundCMethod1(__Pyx_CachedCFunction* cfunc, PyObject* self, PyObject* arg) {
    if (likely(cfunc->func)) {
        int flag = cfunc->flag;
        if (flag == METH_O) {
            return (*(cfunc->func))(self, arg);
        } else if (PY_VERSION_HEX >= 0x030600B1 && flag == METH_FASTCALL) {
            if (PY_VERSION_HEX >= 0x030700A0) {
                return (*(__Pyx_PyCFunctionFast)(void*)(PyCFunction)cfunc->func)(self, &arg, 1);
            } else {
                return (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)cfunc->func)(self, &arg, 1, NULL);
            }
        } else if (PY_VERSION_HEX >= 0x030700A0 && flag == (METH_FASTCALL | METH_KEYWORDS)) {
            return (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)cfunc->func)(self, &arg, 1, NULL);
        }
    }
    return __Pyx__CallUnboundCMethod1(cfunc, self, arg);
}
#endif
static PyObject* __Pyx__CallUnboundCMethod1(__Pyx_CachedCFunction* cfunc, PyObject* self, PyObject* arg){
    PyObject *args, *result = NULL;
    if (unlikely(!cfunc->func && !cfunc->method) && unlikely(__Pyx_TryUnpackUnboundCMethod(cfunc) < 0)) return NULL;
#if CYTHON_COMPILING_IN_CPYTHON
    if (cfunc->func && (cfunc->flag & METH_VARARGS)) {
        args = PyTuple_New(1);
        if (unlikely(!args)) goto bad;
        Py_INCREF(arg);
        PyTuple_SET_ITEM(args, 0, arg);
        if (cfunc->flag & METH_KEYWORDS)
            result = (*(PyCFunctionWithKeywords)(void*)(PyCFunction)cfunc->func)(self, args, NULL);
        else
            result = (*cfunc->func)(self, args);
    } else {
        args = PyTuple_New(2);
        if (unlikely(!args)) goto bad;
        Py_INCREF(self);
        PyTuple_SET_ITEM(args, 0, self);
        Py_INCREF(arg);
        PyTuple_SET_ITEM(args, 1, arg);
        result = __Pyx_PyObject_Call(cfunc->method, args, NULL);
    }
#else
    args = PyTuple_Pack(2, self, arg);
    if (unlikely(!args)) goto bad;
    result = __Pyx_PyObject_Call(cfunc->method, args, NULL);
#endif
bad:
    Py_XDECREF(args);
    return result;
}

/* PyObjectGetMethod */
  static int __Pyx_PyObject_GetMethod(PyObject *obj, PyObject *name, PyObject **method) {
    PyObject *attr;
#if CYTHON_UNPACK_METHODS && CYTHON_COMPILING_IN_CPYTHON && CYTHON_USE_PYTYPE_LOOKUP
    PyTypeObject *tp = Py_TYPE(obj);
    PyObject *descr;
    descrgetfunc f = NULL;
    PyObject **dictptr, *dict;
    int meth_found = 0;
    assert (*method == NULL);
    if (unlikely(tp->tp_getattro != PyObject_GenericGetAttr)) {
        attr = __Pyx_PyObject_GetAttrStr(obj, name);
        goto try_unpack;
    }
    if (unlikely(tp->tp_dict == NULL) && unlikely(PyType_Ready(tp) < 0)) {
        return 0;
    }
    descr = _PyType_Lookup(tp, name);
    if (likely(descr != NULL)) {
        Py_INCREF(descr);
#if PY_MAJOR_VERSION >= 3
        #ifdef __Pyx_CyFunction_USED
        if (likely(PyFunction_Check(descr) || (Py_TYPE(descr) == &PyMethodDescr_Type) || __Pyx_CyFunction_Check(descr)))
        #else
        if (likely(PyFunction_Check(descr) || (Py_TYPE(descr) == &PyMethodDescr_Type)))
        #endif
#else
        #ifdef __Pyx_CyFunction_USED
        if (likely(PyFunction_Check(descr) || __Pyx_CyFunction_Check(descr)))
        #else
        if (likely(PyFunction_Check(descr)))
        #endif
#endif
        {
            meth_found = 1;
        } else {
            f = Py_TYPE(descr)->tp_descr_get;
            if (f != NULL && PyDescr_IsData(descr)) {
                attr = f(descr, obj, (PyObject *)Py_TYPE(obj));
                Py_DECREF(descr);
                goto try_unpack;
            }
        }
    }
    dictptr = _PyObject_GetDictPtr(obj);
    if (dictptr != NULL && (dict = *dictptr) != NULL) {
        Py_INCREF(dict);
        attr = __Pyx_PyDict_GetItemStr(dict, name);
        if (attr != NULL) {
            Py_INCREF(attr);
            Py_DECREF(dict);
            Py_XDECREF(descr);
            goto try_unpack;
        }
        Py_DECREF(dict);
    }
    if (meth_found) {
        *method = descr;
        return 1;
    }
    if (f != NULL) {
        attr = f(descr, obj, (PyObject *)Py_TYPE(obj));
        Py_DECREF(descr);
        goto try_unpack;
    }
    if (descr != NULL) {
        *method = descr;
        return 0;
    }
    PyErr_Format(PyExc_AttributeError,
#if PY_MAJOR_VERSION >= 3
                 "'%.50s' object has no attribute '%U'",
                 tp->tp_name, name);
#else
                 "'%.50s' object has no attribute '%.400s'",
                 tp->tp_name, PyString_AS_STRING(name));
#endif
    return 0;
#else
    attr = __Pyx_PyObject_GetAttrStr(obj, name);
    goto try_unpack;
#endif
try_unpack:
#if CYTHON_UNPACK_METHODS
    if (likely(attr) && PyMethod_Check(attr) && likely(PyMethod_GET_SELF(attr) == obj)) {
        PyObject *function = PyMethod_GET_FUNCTION(attr);
        Py_INCREF(function);
        Py_DECREF(attr);
        *method = function;
        return 1;
    }
#endif
    *method = attr;
    return 0;
}

/* PyObjectCallMethod0 */
  static PyObject* __Pyx_PyObject_CallMethod0(PyObject* obj, PyObject* method_name) {
    PyObject *method = NULL, *result = NULL;
    int is_method = __Pyx_PyObject_GetMethod(obj, method_name, &method);
    if (likely(is_method)) {
        result = __Pyx_PyObject_CallOneArg(method, obj);
        Py_DECREF(method);
        return result;
    }
    if (unlikely(!method)) goto bad;
    result = __Pyx_PyObject_CallNoArg(method);
    Py_DECREF(method);
bad:
    return result;
}

/* RaiseNoneIterError */
  static CYTHON_INLINE void __Pyx_RaiseNoneNotIterableError(void) {
    PyErr_SetString(PyExc_TypeError, "'NoneType' object is not iterable");
}

/* UnpackTupleError */
  static void __Pyx_UnpackTupleError(PyObject *t, Py_ssize_t index) {
    if (t == Py_None) {
      __Pyx_RaiseNoneNotIterableError();
    } else if (PyTuple_GET_SIZE(t) < index) {
      __Pyx_RaiseNeedMoreValuesError(PyTuple_GET_SIZE(t));
    } else {
      __Pyx_RaiseTooManyValuesError(index);
    }
}

/* UnpackTuple2 */
  static CYTHON_INLINE int __Pyx_unpack_tuple2_exact(
        PyObject* tuple, PyObject** pvalue1, PyObject** pvalue2, int decref_tuple) {
    PyObject *value1 = NULL, *value2 = NULL;
#if CYTHON_COMPILING_IN_PYPY
    value1 = PySequence_ITEM(tuple, 0);  if (unlikely(!value1)) goto bad;
    value2 = PySequence_ITEM(tuple, 1);  if (unlikely(!value2)) goto bad;
#else
    value1 = PyTuple_GET_ITEM(tuple, 0);  Py_INCREF(value1);
    value2 = PyTuple_GET_ITEM(tuple, 1);  Py_INCREF(value2);
#endif
    if (decref_tuple) {
        Py_DECREF(tuple);
    }
    *pvalue1 = value1;
    *pvalue2 = value2;
    return 0;
#if CYTHON_COMPILING_IN_PYPY
bad:
    Py_XDECREF(value1);
    Py_XDECREF(value2);
    if (decref_tuple) { Py_XDECREF(tuple); }
    return -1;
#endif
}
static int __Pyx_unpack_tuple2_generic(PyObject* tuple, PyObject** pvalue1, PyObject** pvalue2,
                                       int has_known_size, int decref_tuple) {
    Py_ssize_t index;
    PyObject *value1 = NULL, *value2 = NULL, *iter = NULL;
    iternextfunc iternext;
    iter = PyObject_GetIter(tuple);
    if (unlikely(!iter)) goto bad;
    if (decref_tuple) { Py_DECREF(tuple); tuple = NULL; }
    iternext = Py_TYPE(iter)->tp_iternext;
    value1 = iternext(iter); if (unlikely(!value1)) { index = 0; goto unpacking_failed; }
    value2 = iternext(iter); if (unlikely(!value2)) { index = 1; goto unpacking_failed; }
    if (!has_known_size && unlikely(__Pyx_IternextUnpackEndCheck(iternext(iter), 2))) goto bad;
    Py_DECREF(iter);
    *pvalue1 = value1;
    *pvalue2 = value2;
    return 0;
unpacking_failed:
    if (!has_known_size && __Pyx_IterFinish() == 0)
        __Pyx_RaiseNeedMoreValuesError(index);
bad:
    Py_XDECREF(iter);
    Py_XDECREF(value1);
    Py_XDECREF(value2);
    if (decref_tuple) { Py_XDECREF(tuple); }
    return -1;
}

/* dict_iter */
  static CYTHON_INLINE PyObject* __Pyx_dict_iterator(PyObject* iterable, int is_dict, PyObject* method_name,
                                                   Py_ssize_t* p_orig_length, int* p_source_is_dict) {
    is_dict = is_dict || likely(PyDict_CheckExact(iterable));
    *p_source_is_dict = is_dict;
    if (is_dict) {
#if !CYTHON_COMPILING_IN_PYPY
        *p_orig_length = PyDict_Size(iterable);
        Py_INCREF(iterable);
        return iterable;
#elif PY_MAJOR_VERSION >= 3
        static PyObject *py_items = NULL, *py_keys = NULL, *py_values = NULL;
        PyObject **pp = NULL;
        if (method_name) {
            const char *name = PyUnicode_AsUTF8(method_name);
            if (strcmp(name, "iteritems") == 0) pp = &py_items;
            else if (strcmp(name, "iterkeys") == 0) pp = &py_keys;
            else if (strcmp(name, "itervalues") == 0) pp = &py_values;
            if (pp) {
                if (!*pp) {
                    *pp = PyUnicode_FromString(name + 4);
                    if (!*pp)
                        return NULL;
                }
                method_name = *pp;
            }
        }
#endif
    }
    *p_orig_length = 0;
    if (method_name) {
        PyObject* iter;
        iterable = __Pyx_PyObject_CallMethod0(iterable, method_name);
        if (!iterable)
            return NULL;
#if !CYTHON_COMPILING_IN_PYPY
        if (PyTuple_CheckExact(iterable) || PyList_CheckExact(iterable))
            return iterable;
#endif
        iter = PyObject_GetIter(iterable);
        Py_DECREF(iterable);
        return iter;
    }
    return PyObject_GetIter(iterable);
}
static CYTHON_INLINE int __Pyx_dict_iter_next(
        PyObject* iter_obj, CYTHON_NCP_UNUSED Py_ssize_t orig_length, CYTHON_NCP_UNUSED Py_ssize_t* ppos,
        PyObject** pkey, PyObject** pvalue, PyObject** pitem, int source_is_dict) {
    PyObject* next_item;
#if !CYTHON_COMPILING_IN_PYPY
    if (source_is_dict) {
        PyObject *key, *value;
        if (unlikely(orig_length != PyDict_Size(iter_obj))) {
            PyErr_SetString(PyExc_RuntimeError, "dictionary changed size during iteration");
            return -1;
        }
        if (unlikely(!PyDict_Next(iter_obj, ppos, &key, &value))) {
            return 0;
        }
        if (pitem) {
            PyObject* tuple = PyTuple_New(2);
            if (unlikely(!tuple)) {
                return -1;
            }
            Py_INCREF(key);
            Py_INCREF(value);
            PyTuple_SET_ITEM(tuple, 0, key);
            PyTuple_SET_ITEM(tuple, 1, value);
            *pitem = tuple;
        } else {
            if (pkey) {
                Py_INCREF(key);
                *pkey = key;
            }
            if (pvalue) {
                Py_INCREF(value);
                *pvalue = value;
            }
        }
        return 1;
    } else if (PyTuple_CheckExact(iter_obj)) {
        Py_ssize_t pos = *ppos;
        if (unlikely(pos >= PyTuple_GET_SIZE(iter_obj))) return 0;
        *ppos = pos + 1;
        next_item = PyTuple_GET_ITEM(iter_obj, pos);
        Py_INCREF(next_item);
    } else if (PyList_CheckExact(iter_obj)) {
        Py_ssize_t pos = *ppos;
        if (unlikely(pos >= PyList_GET_SIZE(iter_obj))) return 0;
        *ppos = pos + 1;
        next_item = PyList_GET_ITEM(iter_obj, pos);
        Py_INCREF(next_item);
    } else
#endif
    {
        next_item = PyIter_Next(iter_obj);
        if (unlikely(!next_item)) {
            return __Pyx_IterFinish();
        }
    }
    if (pitem) {
        *pitem = next_item;
    } else if (pkey && pvalue) {
        if (__Pyx_unpack_tuple2(next_item, pkey, pvalue, source_is_dict, source_is_dict, 1))
            return -1;
    } else if (pkey) {
        *pkey = next_item;
    } else {
        *pvalue = next_item;
    }
    return 1;
}

/* GetTopmostException */
  #if CYTHON_USE_EXC_INFO_STACK
static _PyErr_StackItem *
__Pyx_PyErr_GetTopmostException(PyThreadState *tstate)
{
    _PyErr_StackItem *exc_info = tstate->exc_info;
    while ((exc_info->exc_type == NULL || exc_info->exc_type == Py_None) &&
           exc_info->previous_item != NULL)
    {
        exc_info = exc_info->previous_item;
    }
    return exc_info;
}
#endif

/* SaveResetException */
  #if CYTHON_FAST_THREAD_STATE
static CYTHON_INLINE void __Pyx__ExceptionSave(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb) {
    #if CYTHON_USE_EXC_INFO_STACK
    _PyErr_StackItem *exc_info = __Pyx_PyErr_GetTopmostException(tstate);
    *type = exc_info->exc_type;
    *value = exc_info->exc_value;
    *tb = exc_info->exc_traceback;
    #else
    *type = tstate->exc_type;
    *value = tstate->exc_value;
    *tb = tstate->exc_traceback;
    #endif
    Py_XINCREF(*type);
    Py_XINCREF(*value);
    Py_XINCREF(*tb);
}
static CYTHON_INLINE void __Pyx__ExceptionReset(PyThreadState *tstate, PyObject *type, PyObject *value, PyObject *tb) {
    PyObject *tmp_type, *tmp_value, *tmp_tb;
    #if CYTHON_USE_EXC_INFO_STACK
    _PyErr_StackItem *exc_info = tstate->exc_info;
    tmp_type = exc_info->exc_type;
    tmp_value = exc_info->exc_value;
    tmp_tb = exc_info->exc_traceback;
    exc_info->exc_type = type;
    exc_info->exc_value = value;
    exc_info->exc_traceback = tb;
    #else
    tmp_type = tstate->exc_type;
    tmp_value = tstate->exc_value;
    tmp_tb = tstate->exc_traceback;
    tstate->exc_type = type;
    tstate->exc_value = value;
    tstate->exc_traceback = tb;
    #endif
    Py_XDECREF(tmp_type);
    Py_XDECREF(tmp_value);
    Py_XDECREF(tmp_tb);
}
#endif

/* GetException */
  #if CYTHON_FAST_THREAD_STATE
static int __Pyx__GetException(PyThreadState *tstate, PyObject **type, PyObject **value, PyObject **tb)
#else
static int __Pyx_GetException(PyObject **type, PyObject **value, PyObject **tb)
#endif
{
    PyObject *local_type, *local_value, *local_tb;
#if CYTHON_FAST_THREAD_STATE
    PyObject *tmp_type, *tmp_value, *tmp_tb;
    local_type = tstate->curexc_type;
    local_value = tstate->curexc_value;
    local_tb = tstate->curexc_traceback;
    tstate->curexc_type = 0;
    tstate->curexc_value = 0;
    tstate->curexc_traceback = 0;
#else
    PyErr_Fetch(&local_type, &local_value, &local_tb);
#endif
    PyErr_NormalizeException(&local_type, &local_value, &local_tb);
#if CYTHON_FAST_THREAD_STATE
    if (unlikely(tstate->curexc_type))
#else
    if (unlikely(PyErr_Occurred()))
#endif
        goto bad;
    #if PY_MAJOR_VERSION >= 3
    if (local_tb) {
        if (unlikely(PyException_SetTraceback(local_value, local_tb) < 0))
            goto bad;
    }
    #endif
    Py_XINCREF(local_tb);
    Py_XINCREF(local_type);
    Py_XINCREF(local_value);
    *type = local_type;
    *value = local_value;
    *tb = local_tb;
#if CYTHON_FAST_THREAD_STATE
    #if CYTHON_USE_EXC_INFO_STACK
    {
        _PyErr_StackItem *exc_info = tstate->exc_info;
        tmp_type = exc_info->exc_type;
        tmp_value = exc_info->exc_value;
        tmp_tb = exc_info->exc_traceback;
        exc_info->exc_type = local_type;
        exc_info->exc_value = local_value;
        exc_info->exc_traceback = local_tb;
    }
    #else
    tmp_type = tstate->exc_type;
    tmp_value = tstate->exc_value;
    tmp_tb = tstate->exc_traceback;
    tstate->exc_type = local_type;
    tstate->exc_value = local_value;
    tstate->exc_traceback = local_tb;
    #endif
    Py_XDECREF(tmp_type);
    Py_XDECREF(tmp_value);
    Py_XDECREF(tmp_tb);
#else
    PyErr_SetExcInfo(local_type, local_value, local_tb);
#endif
    return 0;
bad:
    *type = 0;
    *value = 0;
    *tb = 0;
    Py_XDECREF(local_type);
    Py_XDECREF(local_value);
    Py_XDECREF(local_tb);
    return -1;
}

/* CallUnboundCMethod2 */
  #if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030600B1
static CYTHON_INLINE PyObject *__Pyx_CallUnboundCMethod2(__Pyx_CachedCFunction *cfunc, PyObject *self, PyObject *arg1, PyObject *arg2) {
    if (likely(cfunc->func)) {
        PyObject *args[2] = {arg1, arg2};
        if (cfunc->flag == METH_FASTCALL) {
            #if PY_VERSION_HEX >= 0x030700A0
            return (*(__Pyx_PyCFunctionFast)(void*)(PyCFunction)cfunc->func)(self, args, 2);
            #else
            return (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)cfunc->func)(self, args, 2, NULL);
            #endif
        }
        #if PY_VERSION_HEX >= 0x030700A0
        if (cfunc->flag == (METH_FASTCALL | METH_KEYWORDS))
            return (*(__Pyx_PyCFunctionFastWithKeywords)(void*)(PyCFunction)cfunc->func)(self, args, 2, NULL);
        #endif
    }
    return __Pyx__CallUnboundCMethod2(cfunc, self, arg1, arg2);
}
#endif
static PyObject* __Pyx__CallUnboundCMethod2(__Pyx_CachedCFunction* cfunc, PyObject* self, PyObject* arg1, PyObject* arg2){
    PyObject *args, *result = NULL;
    if (unlikely(!cfunc->func && !cfunc->method) && unlikely(__Pyx_TryUnpackUnboundCMethod(cfunc) < 0)) return NULL;
#if CYTHON_COMPILING_IN_CPYTHON
    if (cfunc->func && (cfunc->flag & METH_VARARGS)) {
        args = PyTuple_New(2);
        if (unlikely(!args)) goto bad;
        Py_INCREF(arg1);
        PyTuple_SET_ITEM(args, 0, arg1);
        Py_INCREF(arg2);
        PyTuple_SET_ITEM(args, 1, arg2);
        if (cfunc->flag & METH_KEYWORDS)
            result = (*(PyCFunctionWithKeywords)(void*)(PyCFunction)cfunc->func)(self, args, NULL);
        else
            result = (*cfunc->func)(self, args);
    } else {
        args = PyTuple_New(3);
        if (unlikely(!args)) goto bad;
        Py_INCREF(self);
        PyTuple_SET_ITEM(args, 0, self);
        Py_INCREF(arg1);
        PyTuple_SET_ITEM(args, 1, arg1);
        Py_INCREF(arg2);
        PyTuple_SET_ITEM(args, 2, arg2);
        result = __Pyx_PyObject_Call(cfunc->method, args, NULL);
    }
#else
    args = PyTuple_Pack(3, self, arg1, arg2);
    if (unlikely(!args)) goto bad;
    result = __Pyx_PyObject_Call(cfunc->method, args, NULL);
#endif
bad:
    Py_XDECREF(args);
    return result;
}

/* py_dict_pop */
  static CYTHON_INLINE PyObject *__Pyx_PyDict_Pop(PyObject *d, PyObject *key, PyObject *default_value) {
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX > 0x030600B3
    if ((1)) {
        return _PyDict_Pop(d, key, default_value);
    } else
#endif
    if (default_value) {
        return __Pyx_CallUnboundCMethod2(&__pyx_umethod_PyDict_Type_pop, d, key, default_value);
    } else {
        return __Pyx_CallUnboundCMethod1(&__pyx_umethod_PyDict_Type_pop, d, key);
    }
}

/* BufferFallbackError */
  static void __Pyx_RaiseBufferFallbackError(void) {
  PyErr_SetString(PyExc_ValueError,
     "Buffer acquisition failed on assignment; and then reacquiring the old buffer failed too!");
}

/* CallUnboundCMethod0 */
  static PyObject* __Pyx__CallUnboundCMethod0(__Pyx_CachedCFunction* cfunc, PyObject* self) {
    PyObject *args, *result = NULL;
    if (unlikely(!cfunc->method) && unlikely(__Pyx_TryUnpackUnboundCMethod(cfunc) < 0)) return NULL;
#if CYTHON_ASSUME_SAFE_MACROS
    args = PyTuple_New(1);
    if (unlikely(!args)) goto bad;
    Py_INCREF(self);
    PyTuple_SET_ITEM(args, 0, self);
#else
    args = PyTuple_Pack(1, self);
    if (unlikely(!args)) goto bad;
#endif
    result = __Pyx_PyObject_Call(cfunc->method, args, NULL);
    Py_DECREF(args);
bad:
    return result;
}

/* py_dict_values */
  static CYTHON_INLINE PyObject* __Pyx_PyDict_Values(PyObject* d) {
    if (PY_MAJOR_VERSION >= 3)
        return __Pyx_CallUnboundCMethod0(&__pyx_umethod_PyDict_Type_values, d);
    else
        return PyDict_Values(d);
}

/* py_dict_keys */
  static CYTHON_INLINE PyObject* __Pyx_PyDict_Keys(PyObject* d) {
    if (PY_MAJOR_VERSION >= 3)
        return __Pyx_CallUnboundCMethod0(&__pyx_umethod_PyDict_Type_keys, d);
    else
        return PyDict_Keys(d);
}

/* PyIntCompare */
  static CYTHON_INLINE PyObject* __Pyx_PyInt_EqObjC(PyObject *op1, PyObject *op2, CYTHON_UNUSED long intval, CYTHON_UNUSED long inplace) {
    if (op1 == op2) {
        Py_RETURN_TRUE;
    }
    #if PY_MAJOR_VERSION < 3
    if (likely(PyInt_CheckExact(op1))) {
        const long b = intval;
        long a = PyInt_AS_LONG(op1);
        if (a == b) Py_RETURN_TRUE; else Py_RETURN_FALSE;
    }
    #endif
    #if CYTHON_USE_PYLONG_INTERNALS
    if (likely(PyLong_CheckExact(op1))) {
        int unequal;
        unsigned long uintval;
        Py_ssize_t size = Py_SIZE(op1);
        const digit* digits = ((PyLongObject*)op1)->ob_digit;
        if (intval == 0) {
            if (size == 0) Py_RETURN_TRUE; else Py_RETURN_FALSE;
        } else if (intval < 0) {
            if (size >= 0)
                Py_RETURN_FALSE;
            intval = -intval;
            size = -size;
        } else {
            if (size <= 0)
                Py_RETURN_FALSE;
        }
        uintval = (unsigned long) intval;
#if PyLong_SHIFT * 4 < SIZEOF_LONG*8
        if (uintval >> (PyLong_SHIFT * 4)) {
            unequal = (size != 5) || (digits[0] != (uintval & (unsigned long) PyLong_MASK))
                 | (digits[1] != ((uintval >> (1 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK)) | (digits[2] != ((uintval >> (2 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK)) | (digits[3] != ((uintval >> (3 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK)) | (digits[4] != ((uintval >> (4 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK));
        } else
#endif
#if PyLong_SHIFT * 3 < SIZEOF_LONG*8
        if (uintval >> (PyLong_SHIFT * 3)) {
            unequal = (size != 4) || (digits[0] != (uintval & (unsigned long) PyLong_MASK))
                 | (digits[1] != ((uintval >> (1 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK)) | (digits[2] != ((uintval >> (2 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK)) | (digits[3] != ((uintval >> (3 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK));
        } else
#endif
#if PyLong_SHIFT * 2 < SIZEOF_LONG*8
        if (uintval >> (PyLong_SHIFT * 2)) {
            unequal = (size != 3) || (digits[0] != (uintval & (unsigned long) PyLong_MASK))
                 | (digits[1] != ((uintval >> (1 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK)) | (digits[2] != ((uintval >> (2 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK));
        } else
#endif
#if PyLong_SHIFT * 1 < SIZEOF_LONG*8
        if (uintval >> (PyLong_SHIFT * 1)) {
            unequal = (size != 2) || (digits[0] != (uintval & (unsigned long) PyLong_MASK))
                 | (digits[1] != ((uintval >> (1 * PyLong_SHIFT)) & (unsigned long) PyLong_MASK));
        } else
#endif
            unequal = (size != 1) || (((unsigned long) digits[0]) != (uintval & (unsigned long) PyLong_MASK));
        if (unequal == 0) Py_RETURN_TRUE; else Py_RETURN_FALSE;
    }
    #endif
    if (PyFloat_CheckExact(op1)) {
        const long b = intval;
        double a = PyFloat_AS_DOUBLE(op1);
        if ((double)a == (double)b) Py_RETURN_TRUE; else Py_RETURN_FALSE;
    }
    return (
        PyObject_RichCompare(op1, op2, Py_EQ));
}

/* dict_getitem_default */
  static PyObject* __Pyx_PyDict_GetItemDefault(PyObject* d, PyObject* key, PyObject* default_value) {
    PyObject* value;
#if PY_MAJOR_VERSION >= 3 && !CYTHON_COMPILING_IN_PYPY
    value = PyDict_GetItemWithError(d, key);
    if (unlikely(!value)) {
        if (unlikely(PyErr_Occurred()))
            return NULL;
        value = default_value;
    }
    Py_INCREF(value);
    if ((1));
#else
    if (PyString_CheckExact(key) || PyUnicode_CheckExact(key) || PyInt_CheckExact(key)) {
        value = PyDict_GetItem(d, key);
        if (unlikely(!value)) {
            value = default_value;
        }
        Py_INCREF(value);
    }
#endif
    else {
        if (default_value == Py_None)
            value = __Pyx_CallUnboundCMethod1(&__pyx_umethod_PyDict_Type_get, d, key);
        else
            value = __Pyx_CallUnboundCMethod2(&__pyx_umethod_PyDict_Type_get, d, key, default_value);
    }
    return value;
}

/* PyObjectFormat */
  #if CYTHON_USE_UNICODE_WRITER
static PyObject* __Pyx_PyObject_Format(PyObject* obj, PyObject* format_spec) {
    int ret;
    _PyUnicodeWriter writer;
    if (likely(PyFloat_CheckExact(obj))) {
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x03040000
        _PyUnicodeWriter_Init(&writer, 0);
#else
        _PyUnicodeWriter_Init(&writer);
#endif
        ret = _PyFloat_FormatAdvancedWriter(
            &writer,
            obj,
            format_spec, 0, PyUnicode_GET_LENGTH(format_spec));
    } else if (likely(PyLong_CheckExact(obj))) {
#if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX < 0x03040000
        _PyUnicodeWriter_Init(&writer, 0);
#else
        _PyUnicodeWriter_Init(&writer);
#endif
        ret = _PyLong_FormatAdvancedWriter(
            &writer,
            obj,
            format_spec, 0, PyUnicode_GET_LENGTH(format_spec));
    } else {
        return PyObject_Format(obj, format_spec);
    }
    if (unlikely(ret == -1)) {
        _PyUnicodeWriter_Dealloc(&writer);
        return NULL;
    }
    return _PyUnicodeWriter_Finish(&writer);
}
#endif

/* JoinPyUnicode */
  static PyObject* __Pyx_PyUnicode_Join(PyObject* value_tuple, Py_ssize_t value_count, Py_ssize_t result_ulength,
                                      CYTHON_UNUSED Py_UCS4 max_char) {
#if CYTHON_USE_UNICODE_INTERNALS && CYTHON_ASSUME_SAFE_MACROS && !CYTHON_AVOID_BORROWED_REFS
    PyObject *result_uval;
    int result_ukind;
    Py_ssize_t i, char_pos;
    void *result_udata;
#if CYTHON_PEP393_ENABLED
    result_uval = PyUnicode_New(result_ulength, max_char);
    if (unlikely(!result_uval)) return NULL;
    result_ukind = (max_char <= 255) ? PyUnicode_1BYTE_KIND : (max_char <= 65535) ? PyUnicode_2BYTE_KIND : PyUnicode_4BYTE_KIND;
    result_udata = PyUnicode_DATA(result_uval);
#else
    result_uval = PyUnicode_FromUnicode(NULL, result_ulength);
    if (unlikely(!result_uval)) return NULL;
    result_ukind = sizeof(Py_UNICODE);
    result_udata = PyUnicode_AS_UNICODE(result_uval);
#endif
    char_pos = 0;
    for (i=0; i < value_count; i++) {
        int ukind;
        Py_ssize_t ulength;
        void *udata;
        PyObject *uval = PyTuple_GET_ITEM(value_tuple, i);
        if (unlikely(__Pyx_PyUnicode_READY(uval)))
            goto bad;
        ulength = __Pyx_PyUnicode_GET_LENGTH(uval);
        if (unlikely(!ulength))
            continue;
        if (unlikely(char_pos + ulength < 0))
            goto overflow;
        ukind = __Pyx_PyUnicode_KIND(uval);
        udata = __Pyx_PyUnicode_DATA(uval);
        if (!CYTHON_PEP393_ENABLED || ukind == result_ukind) {
            memcpy((char *)result_udata + char_pos * result_ukind, udata, (size_t) (ulength * result_ukind));
        } else {
            #if CYTHON_COMPILING_IN_CPYTHON && PY_VERSION_HEX >= 0x030300F0 || defined(_PyUnicode_FastCopyCharacters)
            _PyUnicode_FastCopyCharacters(result_uval, char_pos, uval, 0, ulength);
            #else
            Py_ssize_t j;
            for (j=0; j < ulength; j++) {
                Py_UCS4 uchar = __Pyx_PyUnicode_READ(ukind, udata, j);
                __Pyx_PyUnicode_WRITE(result_ukind, result_udata, char_pos+j, uchar);
            }
            #endif
        }
        char_pos += ulength;
    }
    return result_uval;
overflow:
    PyErr_SetString(PyExc_OverflowError, "join() result is too long for a Python string");
bad:
    Py_DECREF(result_uval);
    return NULL;
#else
    result_ulength++;
    value_count++;
    return PyUnicode_Join(__pyx_empty_unicode, value_tuple);
#endif
}

/* decode_c_bytes */
  static CYTHON_INLINE PyObject* __Pyx_decode_c_bytes(
         const char* cstring, Py_ssize_t length, Py_ssize_t start, Py_ssize_t stop,
         const char* encoding, const char* errors,
         PyObject* (*decode_func)(const char *s, Py_ssize_t size, const char *errors)) {
    if (unlikely((start < 0) | (stop < 0))) {
        if (start < 0) {
            start += length;
            if (start < 0)
                start = 0;
        }
        if (stop < 0)
            stop += length;
    }
    if (stop > length)
        stop = length;
    length = stop - start;
    if (unlikely(length <= 0))
        return PyUnicode_FromUnicode(NULL, 0);
    cstring += start;
    if (decode_func) {
        return decode_func(cstring, length, errors);
    } else {
        return PyUnicode_Decode(cstring, length, encoding, errors);
    }
}

/* BytesEquals */
  static CYTHON_INLINE int __Pyx_PyBytes_Equals(PyObject* s1, PyObject* s2, int equals) {
#if CYTHON_COMPILING_IN_PYPY
    return PyObject_RichCompareBool(s1, s2, equals);
#else
    if (s1 == s2) {
        return (equals == Py_EQ);
    } else if (PyBytes_CheckExact(s1) & PyBytes_CheckExact(s2)) {
        const char *ps1, *ps2;
        Py_ssize_t length = PyBytes_GET_SIZE(s1);
        if (length != PyBytes_GET_SIZE(s2))
            return (equals == Py_NE);
        ps1 = PyBytes_AS_STRING(s1);
        ps2 = PyBytes_AS_STRING(s2);
        if (ps1[0] != ps2[0]) {
            return (equals == Py_NE);
        } else if (length == 1) {
            return (equals == Py_EQ);
        } else {
            int result;
#if CYTHON_USE_UNICODE_INTERNALS
            Py_hash_t hash1, hash2;
            hash1 = ((PyBytesObject*)s1)->ob_shash;
            hash2 = ((PyBytesObject*)s2)->ob_shash;
            if (hash1 != hash2 && hash1 != -1 && hash2 != -1) {
                return (equals == Py_NE);
            }
#endif
            result = memcmp(ps1, ps2, (size_t)length);
            return (equals == Py_EQ) ? (result == 0) : (result != 0);
        }
    } else if ((s1 == Py_None) & PyBytes_CheckExact(s2)) {
        return (equals == Py_NE);
    } else if ((s2 == Py_None) & PyBytes_CheckExact(s1)) {
        return (equals == Py_NE);
    } else {
        int result;
        PyObject* py_result = PyObject_RichCompare(s1, s2, equals);
        if (!py_result)
            return -1;
        result = __Pyx_PyObject_IsTrue(py_result);
        Py_DECREF(py_result);
        return result;
    }
#endif
}

/* UnicodeEquals */
  static CYTHON_INLINE int __Pyx_PyUnicode_Equals(PyObject* s1, PyObject* s2, int equals) {
#if CYTHON_COMPILING_IN_PYPY
    return PyObject_RichCompareBool(s1, s2, equals);
#else
#if PY_MAJOR_VERSION < 3
    PyObject* owned_ref = NULL;
#endif
    int s1_is_unicode, s2_is_unicode;
    if (s1 == s2) {
        goto return_eq;
    }
    s1_is_unicode = PyUnicode_CheckExact(s1);
    s2_is_unicode = PyUnicode_CheckExact(s2);
#if PY_MAJOR_VERSION < 3
    if ((s1_is_unicode & (!s2_is_unicode)) && PyString_CheckExact(s2)) {
        owned_ref = PyUnicode_FromObject(s2);
        if (unlikely(!owned_ref))
            return -1;
        s2 = owned_ref;
        s2_is_unicode = 1;
    } else if ((s2_is_unicode & (!s1_is_unicode)) && PyString_CheckExact(s1)) {
        owned_ref = PyUnicode_FromObject(s1);
        if (unlikely(!owned_ref))
            return -1;
        s1 = owned_ref;
        s1_is_unicode = 1;
    } else if (((!s2_is_unicode) & (!s1_is_unicode))) {
        return __Pyx_PyBytes_Equals(s1, s2, equals);
    }
#endif
    if (s1_is_unicode & s2_is_unicode) {
        Py_ssize_t length;
        int kind;
        void *data1, *data2;
        if (unlikely(__Pyx_PyUnicode_READY(s1) < 0) || unlikely(__Pyx_PyUnicode_READY(s2) < 0))
            return -1;
        length = __Pyx_PyUnicode_GET_LENGTH(s1);
        if (length != __Pyx_PyUnicode_GET_LENGTH(s2)) {
            goto return_ne;
        }
#if CYTHON_USE_UNICODE_INTERNALS
        {
            Py_hash_t hash1, hash2;
        #if CYTHON_PEP393_ENABLED
            hash1 = ((PyASCIIObject*)s1)->hash;
            hash2 = ((PyASCIIObject*)s2)->hash;
        #else
            hash1 = ((PyUnicodeObject*)s1)->hash;
            hash2 = ((PyUnicodeObject*)s2)->hash;
        #endif
            if (hash1 != hash2 && hash1 != -1 && hash2 != -1) {
                goto return_ne;
            }
        }
#endif
        kind = __Pyx_PyUnicode_KIND(s1);
        if (kind != __Pyx_PyUnicode_KIND(s2)) {
            goto return_ne;
        }
        data1 = __Pyx_PyUnicode_DATA(s1);
        data2 = __Pyx_PyUnicode_DATA(s2);
        if (__Pyx_PyUnicode_READ(kind, data1, 0) != __Pyx_PyUnicode_READ(kind, data2, 0)) {
            goto return_ne;
        } else if (length == 1) {
            goto return_eq;
        } else {
            int result = memcmp(data1, data2, (size_t)(length * kind));
            #if PY_MAJOR_VERSION < 3
            Py_XDECREF(owned_ref);
            #endif
            return (equals == Py_EQ) ? (result == 0) : (result != 0);
        }
    } else if ((s1 == Py_None) & s2_is_unicode) {
        goto return_ne;
    } else if ((s2 == Py_None) & s1_is_unicode) {
        goto return_ne;
    } else {
        int result;
        PyObject* py_result = PyObject_RichCompare(s1, s2, equals);
        #if PY_MAJOR_VERSION < 3
        Py_XDECREF(owned_ref);
        #endif
        if (!py_result)
            return -1;
        result = __Pyx_PyObject_IsTrue(py_result);
        Py_DECREF(py_result);
        return result;
    }
return_eq:
    #if PY_MAJOR_VERSION < 3
    Py_XDECREF(owned_ref);
    #endif
    return (equals == Py_EQ);
return_ne:
    #if PY_MAJOR_VERSION < 3
    Py_XDECREF(owned_ref);
    #endif
    return (equals == Py_NE);
#endif
}

/* None */
  static CYTHON_INLINE void __Pyx_RaiseUnboundLocalError(const char *varname) {
    PyErr_Format(PyExc_UnboundLocalError, "local variable '%s' referenced before assignment", varname);
}

/* None */
  static CYTHON_INLINE Py_ssize_t __Pyx_div_Py_ssize_t(Py_ssize_t a, Py_ssize_t b) {
    Py_ssize_t q = a / b;
    Py_ssize_t r = a - q*b;
    q -= ((r != 0) & ((r ^ b) < 0));
    return q;
}

/* PyIntBinop */
  #if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyInt_AddObjC(PyObject *op1, PyObject *op2, CYTHON_UNUSED long intval, int inplace, int zerodivision_check) {
    (void)inplace;
    (void)zerodivision_check;
    #if PY_MAJOR_VERSION < 3
    if (likely(PyInt_CheckExact(op1))) {
        const long b = intval;
        long x;
        long a = PyInt_AS_LONG(op1);
            x = (long)((unsigned long)a + b);
            if (likely((x^a) >= 0 || (x^b) >= 0))
                return PyInt_FromLong(x);
            return PyLong_Type.tp_as_number->nb_add(op1, op2);
    }
    #endif
    #if CYTHON_USE_PYLONG_INTERNALS
    if (likely(PyLong_CheckExact(op1))) {
        const long b = intval;
        long a, x;
#ifdef HAVE_LONG_LONG
        const PY_LONG_LONG llb = intval;
        PY_LONG_LONG lla, llx;
#endif
        const digit* digits = ((PyLongObject*)op1)->ob_digit;
        const Py_ssize_t size = Py_SIZE(op1);
        if (likely(__Pyx_sst_abs(size) <= 1)) {
            a = likely(size) ? digits[0] : 0;
            if (size == -1) a = -a;
        } else {
            switch (size) {
                case -2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                        a = -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 2 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case 2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                        a = (long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 2 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case -3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                        a = -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 3 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((((unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case 3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                        a = (long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 3 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((((unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case -4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                        a = -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 4 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((((((unsigned PY_LONG_LONG)digits[3]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case 4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                        a = (long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 4 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((((((unsigned PY_LONG_LONG)digits[3]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                default: return PyLong_Type.tp_as_number->nb_add(op1, op2);
            }
        }
                x = a + b;
            return PyLong_FromLong(x);
#ifdef HAVE_LONG_LONG
        long_long:
                llx = lla + llb;
            return PyLong_FromLongLong(llx);
#endif
        
        
    }
    #endif
    if (PyFloat_CheckExact(op1)) {
        const long b = intval;
        double a = PyFloat_AS_DOUBLE(op1);
            double result;
            PyFPE_START_PROTECT("add", return NULL)
            result = ((double)a) + (double)b;
            PyFPE_END_PROTECT(result)
            return PyFloat_FromDouble(result);
    }
    return (inplace ? PyNumber_InPlaceAdd : PyNumber_Add)(op1, op2);
}
#endif

/* PyIntBinop */
  #if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyInt_SubtractObjC(PyObject *op1, PyObject *op2, CYTHON_UNUSED long intval, int inplace, int zerodivision_check) {
    (void)inplace;
    (void)zerodivision_check;
    #if PY_MAJOR_VERSION < 3
    if (likely(PyInt_CheckExact(op1))) {
        const long b = intval;
        long x;
        long a = PyInt_AS_LONG(op1);
            x = (long)((unsigned long)a - b);
            if (likely((x^a) >= 0 || (x^~b) >= 0))
                return PyInt_FromLong(x);
            return PyLong_Type.tp_as_number->nb_subtract(op1, op2);
    }
    #endif
    #if CYTHON_USE_PYLONG_INTERNALS
    if (likely(PyLong_CheckExact(op1))) {
        const long b = intval;
        long a, x;
#ifdef HAVE_LONG_LONG
        const PY_LONG_LONG llb = intval;
        PY_LONG_LONG lla, llx;
#endif
        const digit* digits = ((PyLongObject*)op1)->ob_digit;
        const Py_ssize_t size = Py_SIZE(op1);
        if (likely(__Pyx_sst_abs(size) <= 1)) {
            a = likely(size) ? digits[0] : 0;
            if (size == -1) a = -a;
        } else {
            switch (size) {
                case -2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                        a = -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 2 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case 2:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                        a = (long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 2 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case -3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                        a = -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 3 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((((unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case 3:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                        a = (long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 3 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((((unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case -4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                        a = -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 4 * PyLong_SHIFT) {
                        lla = -(PY_LONG_LONG) (((((((((unsigned PY_LONG_LONG)digits[3]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                case 4:
                    if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                        a = (long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                        break;
#ifdef HAVE_LONG_LONG
                    } else if (8 * sizeof(PY_LONG_LONG) - 1 > 4 * PyLong_SHIFT) {
                        lla = (PY_LONG_LONG) (((((((((unsigned PY_LONG_LONG)digits[3]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[2]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[1]) << PyLong_SHIFT) | (unsigned PY_LONG_LONG)digits[0]));
                        goto long_long;
#endif
                    }
                    CYTHON_FALLTHROUGH;
                default: return PyLong_Type.tp_as_number->nb_subtract(op1, op2);
            }
        }
                x = a - b;
            return PyLong_FromLong(x);
#ifdef HAVE_LONG_LONG
        long_long:
                llx = lla - llb;
            return PyLong_FromLongLong(llx);
#endif
        
        
    }
    #endif
    if (PyFloat_CheckExact(op1)) {
        const long b = intval;
        double a = PyFloat_AS_DOUBLE(op1);
            double result;
            PyFPE_START_PROTECT("subtract", return NULL)
            result = ((double)a) - (double)b;
            PyFPE_END_PROTECT(result)
            return PyFloat_FromDouble(result);
    }
    return (inplace ? PyNumber_InPlaceSubtract : PyNumber_Subtract)(op1, op2);
}
#endif

/* PyFloatBinop */
  #if !CYTHON_COMPILING_IN_PYPY
static PyObject* __Pyx_PyFloat_TrueDivideObjC(PyObject *op1, PyObject *op2, double floatval, int inplace, int zerodivision_check) {
    const double b = floatval;
    double a, result;
    (void)inplace;
    (void)zerodivision_check;
    if (likely(PyFloat_CheckExact(op1))) {
        a = PyFloat_AS_DOUBLE(op1);
        
    } else
    #if PY_MAJOR_VERSION < 3
    if (likely(PyInt_CheckExact(op1))) {
        a = (double) PyInt_AS_LONG(op1);
        
    } else
    #endif
    if (likely(PyLong_CheckExact(op1))) {
        #if CYTHON_USE_PYLONG_INTERNALS
        const digit* digits = ((PyLongObject*)op1)->ob_digit;
        const Py_ssize_t size = Py_SIZE(op1);
        switch (size) {
            case  0: a = 0.0; break;
            case -1: a = -(double) digits[0]; break;
            case  1: a = (double) digits[0]; break;
            case -2:
            case 2:
                if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT && ((8 * sizeof(unsigned long) < 53) || (1 * PyLong_SHIFT < 53))) {
                    a = (double) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                    if ((8 * sizeof(unsigned long) < 53) || (2 * PyLong_SHIFT < 53) || (a < (double) ((PY_LONG_LONG)1 << 53))) {
                        if (size == -2)
                            a = -a;
                        break;
                    }
                }
                CYTHON_FALLTHROUGH;
            case -3:
            case 3:
                if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT && ((8 * sizeof(unsigned long) < 53) || (2 * PyLong_SHIFT < 53))) {
                    a = (double) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                    if ((8 * sizeof(unsigned long) < 53) || (3 * PyLong_SHIFT < 53) || (a < (double) ((PY_LONG_LONG)1 << 53))) {
                        if (size == -3)
                            a = -a;
                        break;
                    }
                }
                CYTHON_FALLTHROUGH;
            case -4:
            case 4:
                if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT && ((8 * sizeof(unsigned long) < 53) || (3 * PyLong_SHIFT < 53))) {
                    a = (double) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0]));
                    if ((8 * sizeof(unsigned long) < 53) || (4 * PyLong_SHIFT < 53) || (a < (double) ((PY_LONG_LONG)1 << 53))) {
                        if (size == -4)
                            a = -a;
                        break;
                    }
                }
                CYTHON_FALLTHROUGH;
            default:
        #else
        {
        #endif
            a = PyLong_AsDouble(op1);
            if (unlikely(a == -1.0 && PyErr_Occurred())) return NULL;
            
        }
    } else {
        return (inplace ? PyNumber_InPlaceTrueDivide : PyNumber_TrueDivide)(op1, op2);
    }
        
        PyFPE_START_PROTECT("divide", return NULL)
        result = a / b;
        PyFPE_END_PROTECT(result)
        return PyFloat_FromDouble(result);
}
#endif

/* set_iter */
    static CYTHON_INLINE PyObject* __Pyx_set_iterator(PyObject* iterable, int is_set,
                                                  Py_ssize_t* p_orig_length, int* p_source_is_set) {
#if CYTHON_COMPILING_IN_CPYTHON
    is_set = is_set || likely(PySet_CheckExact(iterable) || PyFrozenSet_CheckExact(iterable));
    *p_source_is_set = is_set;
    if (likely(is_set)) {
        *p_orig_length = PySet_Size(iterable);
        Py_INCREF(iterable);
        return iterable;
    }
#else
    (void)is_set;
    *p_source_is_set = 0;
#endif
    *p_orig_length = 0;
    return PyObject_GetIter(iterable);
}
static CYTHON_INLINE int __Pyx_set_iter_next(
        PyObject* iter_obj, Py_ssize_t orig_length,
        Py_ssize_t* ppos, PyObject **value,
        int source_is_set) {
    if (!CYTHON_COMPILING_IN_CPYTHON || unlikely(!source_is_set)) {
        *value = PyIter_Next(iter_obj);
        if (unlikely(!*value)) {
            return __Pyx_IterFinish();
        }
        (void)orig_length;
        (void)ppos;
        return 1;
    }
#if CYTHON_COMPILING_IN_CPYTHON
    if (unlikely(PySet_GET_SIZE(iter_obj) != orig_length)) {
        PyErr_SetString(
            PyExc_RuntimeError,
            "set changed size during iteration");
        return -1;
    }
    {
        Py_hash_t hash;
        int ret = _PySet_NextEntry(iter_obj, ppos, value, &hash);
        assert (ret != -1);
        if (likely(ret)) {
            Py_INCREF(*value);
            return 1;
        }
    }
#endif
    return 0;
}

/* PyErrExceptionMatches */
    #if CYTHON_FAST_THREAD_STATE
static int __Pyx_PyErr_ExceptionMatchesTuple(PyObject *exc_type, PyObject *tuple) {
    Py_ssize_t i, n;
    n = PyTuple_GET_SIZE(tuple);
#if PY_MAJOR_VERSION >= 3
    for (i=0; i<n; i++) {
        if (exc_type == PyTuple_GET_ITEM(tuple, i)) return 1;
    }
#endif
    for (i=0; i<n; i++) {
        if (__Pyx_PyErr_GivenExceptionMatches(exc_type, PyTuple_GET_ITEM(tuple, i))) return 1;
    }
    return 0;
}
static CYTHON_INLINE int __Pyx_PyErr_ExceptionMatchesInState(PyThreadState* tstate, PyObject* err) {
    PyObject *exc_type = tstate->curexc_type;
    if (exc_type == err) return 1;
    if (unlikely(!exc_type)) return 0;
    if (unlikely(PyTuple_Check(err)))
        return __Pyx_PyErr_ExceptionMatchesTuple(exc_type, err);
    return __Pyx_PyErr_GivenExceptionMatches(exc_type, err);
}
#endif

/* StringJoin */
    #if !CYTHON_COMPILING_IN_CPYTHON
static CYTHON_INLINE PyObject* __Pyx_PyBytes_Join(PyObject* sep, PyObject* values) {
    return PyObject_CallMethodObjArgs(sep, __pyx_n_s_join, values, NULL);
}
#endif

/* pyfrozenset_new */
    static CYTHON_INLINE PyObject* __Pyx_PyFrozenSet_New(PyObject* it) {
    if (it) {
        PyObject* result;
#if CYTHON_COMPILING_IN_PYPY
        PyObject* args;
        args = PyTuple_Pack(1, it);
        if (unlikely(!args))
            return NULL;
        result = PyObject_Call((PyObject*)&PyFrozenSet_Type, args, NULL);
        Py_DECREF(args);
        return result;
#else
        if (PyFrozenSet_CheckExact(it)) {
            Py_INCREF(it);
            return it;
        }
        result = PyFrozenSet_New(it);
        if (unlikely(!result))
            return NULL;
        if (likely(PySet_GET_SIZE(result)))
            return result;
        Py_DECREF(result);
#endif
    }
#if CYTHON_USE_TYPE_SLOTS
    return PyFrozenSet_Type.tp_new(&PyFrozenSet_Type, __pyx_empty_tuple, NULL);
#else
    return PyObject_Call((PyObject*)&PyFrozenSet_Type, __pyx_empty_tuple, NULL);
#endif
}

/* PySetContains */
    static int __Pyx_PySet_ContainsUnhashable(PyObject *set, PyObject *key) {
    int result = -1;
    if (PySet_Check(key) && PyErr_ExceptionMatches(PyExc_TypeError)) {
        PyObject *tmpkey;
        PyErr_Clear();
        tmpkey = __Pyx_PyFrozenSet_New(key);
        if (tmpkey != NULL) {
            result = PySet_Contains(set, tmpkey);
            Py_DECREF(tmpkey);
        }
    }
    return result;
}
static CYTHON_INLINE int __Pyx_PySet_ContainsTF(PyObject* key, PyObject* set, int eq) {
    int result = PySet_Contains(set, key);
    if (unlikely(result < 0)) {
        result = __Pyx_PySet_ContainsUnhashable(set, key);
    }
    return unlikely(result < 0) ? result : (result == (eq == Py_EQ));
}

/* PyObject_GenericGetAttrNoDict */
    #if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static PyObject *__Pyx_RaiseGenericGetAttributeError(PyTypeObject *tp, PyObject *attr_name) {
    PyErr_Format(PyExc_AttributeError,
#if PY_MAJOR_VERSION >= 3
                 "'%.50s' object has no attribute '%U'",
                 tp->tp_name, attr_name);
#else
                 "'%.50s' object has no attribute '%.400s'",
                 tp->tp_name, PyString_AS_STRING(attr_name));
#endif
    return NULL;
}
static CYTHON_INLINE PyObject* __Pyx_PyObject_GenericGetAttrNoDict(PyObject* obj, PyObject* attr_name) {
    PyObject *descr;
    PyTypeObject *tp = Py_TYPE(obj);
    if (unlikely(!PyString_Check(attr_name))) {
        return PyObject_GenericGetAttr(obj, attr_name);
    }
    assert(!tp->tp_dictoffset);
    descr = _PyType_Lookup(tp, attr_name);
    if (unlikely(!descr)) {
        return __Pyx_RaiseGenericGetAttributeError(tp, attr_name);
    }
    Py_INCREF(descr);
    #if PY_MAJOR_VERSION < 3
    if (likely(PyType_HasFeature(Py_TYPE(descr), Py_TPFLAGS_HAVE_CLASS)))
    #endif
    {
        descrgetfunc f = Py_TYPE(descr)->tp_descr_get;
        if (unlikely(f)) {
            PyObject *res = f(descr, obj, (PyObject *)tp);
            Py_DECREF(descr);
            return res;
        }
    }
    return descr;
}
#endif

/* PyObject_GenericGetAttr */
    #if CYTHON_USE_TYPE_SLOTS && CYTHON_USE_PYTYPE_LOOKUP && PY_VERSION_HEX < 0x03070000
static PyObject* __Pyx_PyObject_GenericGetAttr(PyObject* obj, PyObject* attr_name) {
    if (unlikely(Py_TYPE(obj)->tp_dictoffset)) {
        return PyObject_GenericGetAttr(obj, attr_name);
    }
    return __Pyx_PyObject_GenericGetAttrNoDict(obj, attr_name);
}
#endif

/* SetVTable */
    static int __Pyx_SetVtable(PyObject *dict, void *vtable) {
#if PY_VERSION_HEX >= 0x02070000
    PyObject *ob = PyCapsule_New(vtable, 0, 0);
#else
    PyObject *ob = PyCObject_FromVoidPtr(vtable, 0);
#endif
    if (!ob)
        goto bad;
    if (PyDict_SetItem(dict, __pyx_n_s_pyx_vtable, ob) < 0)
        goto bad;
    Py_DECREF(ob);
    return 0;
bad:
    Py_XDECREF(ob);
    return -1;
}

/* SetupReduce */
    static int __Pyx_setup_reduce_is_named(PyObject* meth, PyObject* name) {
  int ret;
  PyObject *name_attr;
  name_attr = __Pyx_PyObject_GetAttrStr(meth, __pyx_n_s_name);
  if (likely(name_attr)) {
      ret = PyObject_RichCompareBool(name_attr, name, Py_EQ);
  } else {
      ret = -1;
  }
  if (unlikely(ret < 0)) {
      PyErr_Clear();
      ret = 0;
  }
  Py_XDECREF(name_attr);
  return ret;
}
static int __Pyx_setup_reduce(PyObject* type_obj) {
    int ret = 0;
    PyObject *object_reduce = NULL;
    PyObject *object_reduce_ex = NULL;
    PyObject *reduce = NULL;
    PyObject *reduce_ex = NULL;
    PyObject *reduce_cython = NULL;
    PyObject *setstate = NULL;
    PyObject *setstate_cython = NULL;
#if CYTHON_USE_PYTYPE_LOOKUP
    if (_PyType_Lookup((PyTypeObject*)type_obj, __pyx_n_s_getstate)) goto GOOD;
#else
    if (PyObject_HasAttr(type_obj, __pyx_n_s_getstate)) goto GOOD;
#endif
#if CYTHON_USE_PYTYPE_LOOKUP
    object_reduce_ex = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_reduce_ex); if (!object_reduce_ex) goto BAD;
#else
    object_reduce_ex = __Pyx_PyObject_GetAttrStr((PyObject*)&PyBaseObject_Type, __pyx_n_s_reduce_ex); if (!object_reduce_ex) goto BAD;
#endif
    reduce_ex = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_reduce_ex); if (unlikely(!reduce_ex)) goto BAD;
    if (reduce_ex == object_reduce_ex) {
#if CYTHON_USE_PYTYPE_LOOKUP
        object_reduce = _PyType_Lookup(&PyBaseObject_Type, __pyx_n_s_reduce); if (!object_reduce) goto BAD;
#else
        object_reduce = __Pyx_PyObject_GetAttrStr((PyObject*)&PyBaseObject_Type, __pyx_n_s_reduce); if (!object_reduce) goto BAD;
#endif
        reduce = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_reduce); if (unlikely(!reduce)) goto BAD;
        if (reduce == object_reduce || __Pyx_setup_reduce_is_named(reduce, __pyx_n_s_reduce_cython)) {
            reduce_cython = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_reduce_cython); if (unlikely(!reduce_cython)) goto BAD;
            ret = PyDict_SetItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_reduce, reduce_cython); if (unlikely(ret < 0)) goto BAD;
            ret = PyDict_DelItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_reduce_cython); if (unlikely(ret < 0)) goto BAD;
            setstate = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_setstate);
            if (!setstate) PyErr_Clear();
            if (!setstate || __Pyx_setup_reduce_is_named(setstate, __pyx_n_s_setstate_cython)) {
                setstate_cython = __Pyx_PyObject_GetAttrStr(type_obj, __pyx_n_s_setstate_cython); if (unlikely(!setstate_cython)) goto BAD;
                ret = PyDict_SetItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_setstate, setstate_cython); if (unlikely(ret < 0)) goto BAD;
                ret = PyDict_DelItem(((PyTypeObject*)type_obj)->tp_dict, __pyx_n_s_setstate_cython); if (unlikely(ret < 0)) goto BAD;
            }
            PyType_Modified((PyTypeObject*)type_obj);
        }
    }
    goto GOOD;
BAD:
    if (!PyErr_Occurred())
        PyErr_Format(PyExc_RuntimeError, "Unable to initialize pickling for %s", ((PyTypeObject*)type_obj)->tp_name);
    ret = -1;
GOOD:
#if !CYTHON_USE_PYTYPE_LOOKUP
    Py_XDECREF(object_reduce);
    Py_XDECREF(object_reduce_ex);
#endif
    Py_XDECREF(reduce);
    Py_XDECREF(reduce_ex);
    Py_XDECREF(reduce_cython);
    Py_XDECREF(setstate);
    Py_XDECREF(setstate_cython);
    return ret;
}

/* TypeImport */
    #ifndef __PYX_HAVE_RT_ImportType
#define __PYX_HAVE_RT_ImportType
static PyTypeObject *__Pyx_ImportType(PyObject *module, const char *module_name, const char *class_name,
    size_t size, enum __Pyx_ImportType_CheckSize check_size)
{
    PyObject *result = 0;
    char warning[200];
    Py_ssize_t basicsize;
#ifdef Py_LIMITED_API
    PyObject *py_basicsize;
#endif
    result = PyObject_GetAttrString(module, class_name);
    if (!result)
        goto bad;
    if (!PyType_Check(result)) {
        PyErr_Format(PyExc_TypeError,
            "%.200s.%.200s is not a type object",
            module_name, class_name);
        goto bad;
    }
#ifndef Py_LIMITED_API
    basicsize = ((PyTypeObject *)result)->tp_basicsize;
#else
    py_basicsize = PyObject_GetAttrString(result, "__basicsize__");
    if (!py_basicsize)
        goto bad;
    basicsize = PyLong_AsSsize_t(py_basicsize);
    Py_DECREF(py_basicsize);
    py_basicsize = 0;
    if (basicsize == (Py_ssize_t)-1 && PyErr_Occurred())
        goto bad;
#endif
    if ((size_t)basicsize < size) {
        PyErr_Format(PyExc_ValueError,
            "%.200s.%.200s size changed, may indicate binary incompatibility. "
            "Expected %zd from C header, got %zd from PyObject",
            module_name, class_name, size, basicsize);
        goto bad;
    }
    if (check_size == __Pyx_ImportType_CheckSize_Error && (size_t)basicsize != size) {
        PyErr_Format(PyExc_ValueError,
            "%.200s.%.200s size changed, may indicate binary incompatibility. "
            "Expected %zd from C header, got %zd from PyObject",
            module_name, class_name, size, basicsize);
        goto bad;
    }
    else if (check_size == __Pyx_ImportType_CheckSize_Warn && (size_t)basicsize > size) {
        PyOS_snprintf(warning, sizeof(warning),
            "%s.%s size changed, may indicate binary incompatibility. "
            "Expected %zd from C header, got %zd from PyObject",
            module_name, class_name, size, basicsize);
        if (PyErr_WarnEx(NULL, warning, 0) < 0) goto bad;
    }
    return (PyTypeObject *)result;
bad:
    Py_XDECREF(result);
    return NULL;
}
#endif

/* Import */
    static PyObject *__Pyx_Import(PyObject *name, PyObject *from_list, int level) {
    PyObject *empty_list = 0;
    PyObject *module = 0;
    PyObject *global_dict = 0;
    PyObject *empty_dict = 0;
    PyObject *list;
    #if PY_MAJOR_VERSION < 3
    PyObject *py_import;
    py_import = __Pyx_PyObject_GetAttrStr(__pyx_b, __pyx_n_s_import);
    if (!py_import)
        goto bad;
    #endif
    if (from_list)
        list = from_list;
    else {
        empty_list = PyList_New(0);
        if (!empty_list)
            goto bad;
        list = empty_list;
    }
    global_dict = PyModule_GetDict(__pyx_m);
    if (!global_dict)
        goto bad;
    empty_dict = PyDict_New();
    if (!empty_dict)
        goto bad;
    {
        #if PY_MAJOR_VERSION >= 3
        if (level == -1) {
            if (strchr(__Pyx_MODULE_NAME, '.')) {
                module = PyImport_ImportModuleLevelObject(
                    name, global_dict, empty_dict, list, 1);
                if (!module) {
                    if (!PyErr_ExceptionMatches(PyExc_ImportError))
                        goto bad;
                    PyErr_Clear();
                }
            }
            level = 0;
        }
        #endif
        if (!module) {
            #if PY_MAJOR_VERSION < 3
            PyObject *py_level = PyInt_FromLong(level);
            if (!py_level)
                goto bad;
            module = PyObject_CallFunctionObjArgs(py_import,
                name, global_dict, empty_dict, list, py_level, (PyObject *)NULL);
            Py_DECREF(py_level);
            #else
            module = PyImport_ImportModuleLevelObject(
                name, global_dict, empty_dict, list, level);
            #endif
        }
    }
bad:
    #if PY_MAJOR_VERSION < 3
    Py_XDECREF(py_import);
    #endif
    Py_XDECREF(empty_list);
    Py_XDECREF(empty_dict);
    return module;
}

/* ImportFrom */
    static PyObject* __Pyx_ImportFrom(PyObject* module, PyObject* name) {
    PyObject* value = __Pyx_PyObject_GetAttrStr(module, name);
    if (unlikely(!value) && PyErr_ExceptionMatches(PyExc_AttributeError)) {
        PyErr_Format(PyExc_ImportError,
        #if PY_MAJOR_VERSION < 3
            "cannot import name %.230s", PyString_AS_STRING(name));
        #else
            "cannot import name %S", name);
        #endif
    }
    return value;
}

/* CLineInTraceback */
    #ifndef CYTHON_CLINE_IN_TRACEBACK
static int __Pyx_CLineForTraceback(PyThreadState *tstate, int c_line) {
    PyObject *use_cline;
    PyObject *ptype, *pvalue, *ptraceback;
#if CYTHON_COMPILING_IN_CPYTHON
    PyObject **cython_runtime_dict;
#endif
    if (unlikely(!__pyx_cython_runtime)) {
        return c_line;
    }
    __Pyx_ErrFetchInState(tstate, &ptype, &pvalue, &ptraceback);
#if CYTHON_COMPILING_IN_CPYTHON
    cython_runtime_dict = _PyObject_GetDictPtr(__pyx_cython_runtime);
    if (likely(cython_runtime_dict)) {
        __PYX_PY_DICT_LOOKUP_IF_MODIFIED(
            use_cline, *cython_runtime_dict,
            __Pyx_PyDict_GetItemStr(*cython_runtime_dict, __pyx_n_s_cline_in_traceback))
    } else
#endif
    {
      PyObject *use_cline_obj = __Pyx_PyObject_GetAttrStr(__pyx_cython_runtime, __pyx_n_s_cline_in_traceback);
      if (use_cline_obj) {
        use_cline = PyObject_Not(use_cline_obj) ? Py_False : Py_True;
        Py_DECREF(use_cline_obj);
      } else {
        PyErr_Clear();
        use_cline = NULL;
      }
    }
    if (!use_cline) {
        c_line = 0;
        PyObject_SetAttr(__pyx_cython_runtime, __pyx_n_s_cline_in_traceback, Py_False);
    }
    else if (use_cline == Py_False || (use_cline != Py_True && PyObject_Not(use_cline) != 0)) {
        c_line = 0;
    }
    __Pyx_ErrRestoreInState(tstate, ptype, pvalue, ptraceback);
    return c_line;
}
#endif

/* CodeObjectCache */
    static int __pyx_bisect_code_objects(__Pyx_CodeObjectCacheEntry* entries, int count, int code_line) {
    int start = 0, mid = 0, end = count - 1;
    if (end >= 0 && code_line > entries[end].code_line) {
        return count;
    }
    while (start < end) {
        mid = start + (end - start) / 2;
        if (code_line < entries[mid].code_line) {
            end = mid;
        } else if (code_line > entries[mid].code_line) {
             start = mid + 1;
        } else {
            return mid;
        }
    }
    if (code_line <= entries[mid].code_line) {
        return mid;
    } else {
        return mid + 1;
    }
}
static PyCodeObject *__pyx_find_code_object(int code_line) {
    PyCodeObject* code_object;
    int pos;
    if (unlikely(!code_line) || unlikely(!__pyx_code_cache.entries)) {
        return NULL;
    }
    pos = __pyx_bisect_code_objects(__pyx_code_cache.entries, __pyx_code_cache.count, code_line);
    if (unlikely(pos >= __pyx_code_cache.count) || unlikely(__pyx_code_cache.entries[pos].code_line != code_line)) {
        return NULL;
    }
    code_object = __pyx_code_cache.entries[pos].code_object;
    Py_INCREF(code_object);
    return code_object;
}
static void __pyx_insert_code_object(int code_line, PyCodeObject* code_object) {
    int pos, i;
    __Pyx_CodeObjectCacheEntry* entries = __pyx_code_cache.entries;
    if (unlikely(!code_line)) {
        return;
    }
    if (unlikely(!entries)) {
        entries = (__Pyx_CodeObjectCacheEntry*)PyMem_Malloc(64*sizeof(__Pyx_CodeObjectCacheEntry));
        if (likely(entries)) {
            __pyx_code_cache.entries = entries;
            __pyx_code_cache.max_count = 64;
            __pyx_code_cache.count = 1;
            entries[0].code_line = code_line;
            entries[0].code_object = code_object;
            Py_INCREF(code_object);
        }
        return;
    }
    pos = __pyx_bisect_code_objects(__pyx_code_cache.entries, __pyx_code_cache.count, code_line);
    if ((pos < __pyx_code_cache.count) && unlikely(__pyx_code_cache.entries[pos].code_line == code_line)) {
        PyCodeObject* tmp = entries[pos].code_object;
        entries[pos].code_object = code_object;
        Py_DECREF(tmp);
        return;
    }
    if (__pyx_code_cache.count == __pyx_code_cache.max_count) {
        int new_max = __pyx_code_cache.max_count + 64;
        entries = (__Pyx_CodeObjectCacheEntry*)PyMem_Realloc(
            __pyx_code_cache.entries, (size_t)new_max*sizeof(__Pyx_CodeObjectCacheEntry));
        if (unlikely(!entries)) {
            return;
        }
        __pyx_code_cache.entries = entries;
        __pyx_code_cache.max_count = new_max;
    }
    for (i=__pyx_code_cache.count; i>pos; i--) {
        entries[i] = entries[i-1];
    }
    entries[pos].code_line = code_line;
    entries[pos].code_object = code_object;
    __pyx_code_cache.count++;
    Py_INCREF(code_object);
}

/* AddTraceback */
    #include "compile.h"
#include "frameobject.h"
#include "traceback.h"
static PyCodeObject* __Pyx_CreateCodeObjectForTraceback(
            const char *funcname, int c_line,
            int py_line, const char *filename) {
    PyCodeObject *py_code = 0;
    PyObject *py_srcfile = 0;
    PyObject *py_funcname = 0;
    #if PY_MAJOR_VERSION < 3
    py_srcfile = PyString_FromString(filename);
    #else
    py_srcfile = PyUnicode_FromString(filename);
    #endif
    if (!py_srcfile) goto bad;
    if (c_line) {
        #if PY_MAJOR_VERSION < 3
        py_funcname = PyString_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, c_line);
        #else
        py_funcname = PyUnicode_FromFormat( "%s (%s:%d)", funcname, __pyx_cfilenm, c_line);
        #endif
    }
    else {
        #if PY_MAJOR_VERSION < 3
        py_funcname = PyString_FromString(funcname);
        #else
        py_funcname = PyUnicode_FromString(funcname);
        #endif
    }
    if (!py_funcname) goto bad;
    py_code = __Pyx_PyCode_New(
        0,
        0,
        0,
        0,
        0,
        __pyx_empty_bytes, /*PyObject *code,*/
        __pyx_empty_tuple, /*PyObject *consts,*/
        __pyx_empty_tuple, /*PyObject *names,*/
        __pyx_empty_tuple, /*PyObject *varnames,*/
        __pyx_empty_tuple, /*PyObject *freevars,*/
        __pyx_empty_tuple, /*PyObject *cellvars,*/
        py_srcfile,   /*PyObject *filename,*/
        py_funcname,  /*PyObject *name,*/
        py_line,
        __pyx_empty_bytes  /*PyObject *lnotab*/
    );
    Py_DECREF(py_srcfile);
    Py_DECREF(py_funcname);
    return py_code;
bad:
    Py_XDECREF(py_srcfile);
    Py_XDECREF(py_funcname);
    return NULL;
}
static void __Pyx_AddTraceback(const char *funcname, int c_line,
                               int py_line, const char *filename) {
    PyCodeObject *py_code = 0;
    PyFrameObject *py_frame = 0;
    PyThreadState *tstate = __Pyx_PyThreadState_Current;
    if (c_line) {
        c_line = __Pyx_CLineForTraceback(tstate, c_line);
    }
    py_code = __pyx_find_code_object(c_line ? -c_line : py_line);
    if (!py_code) {
        py_code = __Pyx_CreateCodeObjectForTraceback(
            funcname, c_line, py_line, filename);
        if (!py_code) goto bad;
        __pyx_insert_code_object(c_line ? -c_line : py_line, py_code);
    }
    py_frame = PyFrame_New(
        tstate,            /*PyThreadState *tstate,*/
        py_code,           /*PyCodeObject *code,*/
        __pyx_d,    /*PyObject *globals,*/
        0                  /*PyObject *locals*/
    );
    if (!py_frame) goto bad;
    __Pyx_PyFrame_SetLineNumber(py_frame, py_line);
    PyTraceBack_Here(py_frame);
bad:
    Py_XDECREF(py_code);
    Py_XDECREF(py_frame);
}

#if PY_MAJOR_VERSION < 3
static int __Pyx_GetBuffer(PyObject *obj, Py_buffer *view, int flags) {
    if (PyObject_CheckBuffer(obj)) return PyObject_GetBuffer(obj, view, flags);
        if (__Pyx_TypeCheck(obj, __pyx_ptype_5numpy_ndarray)) return __pyx_pw_5numpy_7ndarray_1__getbuffer__(obj, view, flags);
    PyErr_Format(PyExc_TypeError, "'%.200s' does not have the buffer interface", Py_TYPE(obj)->tp_name);
    return -1;
}
static void __Pyx_ReleaseBuffer(Py_buffer *view) {
    PyObject *obj = view->obj;
    if (!obj) return;
    if (PyObject_CheckBuffer(obj)) {
        PyBuffer_Release(view);
        return;
    }
    if ((0)) {}
        else if (__Pyx_TypeCheck(obj, __pyx_ptype_5numpy_ndarray)) __pyx_pw_5numpy_7ndarray_3__releasebuffer__(obj, view);
    view->obj = NULL;
    Py_DECREF(obj);
}
#endif


    /* CIntFromPyVerify */
    #define __PYX_VERIFY_RETURN_INT(target_type, func_type, func_value)\
    __PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, 0)
#define __PYX_VERIFY_RETURN_INT_EXC(target_type, func_type, func_value)\
    __PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, 1)
#define __PYX__VERIFY_RETURN_INT(target_type, func_type, func_value, exc)\
    {\
        func_type value = func_value;\
        if (sizeof(target_type) < sizeof(func_type)) {\
            if (unlikely(value != (func_type) (target_type) value)) {\
                func_type zero = 0;\
                if (exc && unlikely(value == (func_type)-1 && PyErr_Occurred()))\
                    return (target_type) -1;\
                if (is_unsigned && unlikely(value < zero))\
                    goto raise_neg_overflow;\
                else\
                    goto raise_overflow;\
            }\
        }\
        return (target_type) value;\
    }

/* CIntToPy */
    static CYTHON_INLINE PyObject* __Pyx_PyInt_From_long(long value) {
    const long neg_one = (long) ((long) 0 - (long) 1), const_zero = (long) 0;
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(long) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(long) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(long) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(long) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(long) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
        return _PyLong_FromByteArray(bytes, sizeof(long),
                                     little, !is_unsigned);
    }
}

/* CIntToPy */
    static CYTHON_INLINE PyObject* __Pyx_PyInt_From_npy_int64(npy_int64 value) {
    const npy_int64 neg_one = (npy_int64) ((npy_int64) 0 - (npy_int64) 1), const_zero = (npy_int64) 0;
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(npy_int64) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(npy_int64) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(npy_int64) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(npy_int64) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(npy_int64) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
        return _PyLong_FromByteArray(bytes, sizeof(npy_int64),
                                     little, !is_unsigned);
    }
}

/* CIntToPy */
    static CYTHON_INLINE PyObject* __Pyx_PyInt_From_npy_int32(npy_int32 value) {
    const npy_int32 neg_one = (npy_int32) ((npy_int32) 0 - (npy_int32) 1), const_zero = (npy_int32) 0;
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(npy_int32) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(npy_int32) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(npy_int32) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(npy_int32) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(npy_int32) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
        return _PyLong_FromByteArray(bytes, sizeof(npy_int32),
                                     little, !is_unsigned);
    }
}

/* CIntToPy */
    static CYTHON_INLINE PyObject* __Pyx_PyInt_From_Py_intptr_t(Py_intptr_t value) {
    const Py_intptr_t neg_one = (Py_intptr_t) ((Py_intptr_t) 0 - (Py_intptr_t) 1), const_zero = (Py_intptr_t) 0;
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(Py_intptr_t) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(Py_intptr_t) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(Py_intptr_t) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(Py_intptr_t) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(Py_intptr_t) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
        return _PyLong_FromByteArray(bytes, sizeof(Py_intptr_t),
                                     little, !is_unsigned);
    }
}

/* Declarations */
    #if CYTHON_CCOMPLEX
  #ifdef __cplusplus
    static CYTHON_INLINE __pyx_t_float_complex __pyx_t_float_complex_from_parts(float x, float y) {
      return ::std::complex< float >(x, y);
    }
  #else
    static CYTHON_INLINE __pyx_t_float_complex __pyx_t_float_complex_from_parts(float x, float y) {
      return x + y*(__pyx_t_float_complex)_Complex_I;
    }
  #endif
#else
    static CYTHON_INLINE __pyx_t_float_complex __pyx_t_float_complex_from_parts(float x, float y) {
      __pyx_t_float_complex z;
      z.real = x;
      z.imag = y;
      return z;
    }
#endif

/* Arithmetic */
    #if CYTHON_CCOMPLEX
#else
    static CYTHON_INLINE int __Pyx_c_eq_float(__pyx_t_float_complex a, __pyx_t_float_complex b) {
       return (a.real == b.real) && (a.imag == b.imag);
    }
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_sum_float(__pyx_t_float_complex a, __pyx_t_float_complex b) {
        __pyx_t_float_complex z;
        z.real = a.real + b.real;
        z.imag = a.imag + b.imag;
        return z;
    }
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_diff_float(__pyx_t_float_complex a, __pyx_t_float_complex b) {
        __pyx_t_float_complex z;
        z.real = a.real - b.real;
        z.imag = a.imag - b.imag;
        return z;
    }
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_prod_float(__pyx_t_float_complex a, __pyx_t_float_complex b) {
        __pyx_t_float_complex z;
        z.real = a.real * b.real - a.imag * b.imag;
        z.imag = a.real * b.imag + a.imag * b.real;
        return z;
    }
    #if 1
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_quot_float(__pyx_t_float_complex a, __pyx_t_float_complex b) {
        if (b.imag == 0) {
            return __pyx_t_float_complex_from_parts(a.real / b.real, a.imag / b.real);
        } else if (fabsf(b.real) >= fabsf(b.imag)) {
            if (b.real == 0 && b.imag == 0) {
                return __pyx_t_float_complex_from_parts(a.real / b.real, a.imag / b.imag);
            } else {
                float r = b.imag / b.real;
                float s = (float)(1.0) / (b.real + b.imag * r);
                return __pyx_t_float_complex_from_parts(
                    (a.real + a.imag * r) * s, (a.imag - a.real * r) * s);
            }
        } else {
            float r = b.real / b.imag;
            float s = (float)(1.0) / (b.imag + b.real * r);
            return __pyx_t_float_complex_from_parts(
                (a.real * r + a.imag) * s, (a.imag * r - a.real) * s);
        }
    }
    #else
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_quot_float(__pyx_t_float_complex a, __pyx_t_float_complex b) {
        if (b.imag == 0) {
            return __pyx_t_float_complex_from_parts(a.real / b.real, a.imag / b.real);
        } else {
            float denom = b.real * b.real + b.imag * b.imag;
            return __pyx_t_float_complex_from_parts(
                (a.real * b.real + a.imag * b.imag) / denom,
                (a.imag * b.real - a.real * b.imag) / denom);
        }
    }
    #endif
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_neg_float(__pyx_t_float_complex a) {
        __pyx_t_float_complex z;
        z.real = -a.real;
        z.imag = -a.imag;
        return z;
    }
    static CYTHON_INLINE int __Pyx_c_is_zero_float(__pyx_t_float_complex a) {
       return (a.real == 0) && (a.imag == 0);
    }
    static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_conj_float(__pyx_t_float_complex a) {
        __pyx_t_float_complex z;
        z.real =  a.real;
        z.imag = -a.imag;
        return z;
    }
    #if 1
        static CYTHON_INLINE float __Pyx_c_abs_float(__pyx_t_float_complex z) {
          #if !defined(HAVE_HYPOT) || defined(_MSC_VER)
            return sqrtf(z.real*z.real + z.imag*z.imag);
          #else
            return hypotf(z.real, z.imag);
          #endif
        }
        static CYTHON_INLINE __pyx_t_float_complex __Pyx_c_pow_float(__pyx_t_float_complex a, __pyx_t_float_complex b) {
            __pyx_t_float_complex z;
            float r, lnr, theta, z_r, z_theta;
            if (b.imag == 0 && b.real == (int)b.real) {
                if (b.real < 0) {
                    float denom = a.real * a.real + a.imag * a.imag;
                    a.real = a.real / denom;
                    a.imag = -a.imag / denom;
                    b.real = -b.real;
                }
                switch ((int)b.real) {
                    case 0:
                        z.real = 1;
                        z.imag = 0;
                        return z;
                    case 1:
                        return a;
                    case 2:
                        return __Pyx_c_prod_float(a, a);
                    case 3:
                        z = __Pyx_c_prod_float(a, a);
                        return __Pyx_c_prod_float(z, a);
                    case 4:
                        z = __Pyx_c_prod_float(a, a);
                        return __Pyx_c_prod_float(z, z);
                }
            }
            if (a.imag == 0) {
                if (a.real == 0) {
                    return a;
                } else if (b.imag == 0) {
                    z.real = powf(a.real, b.real);
                    z.imag = 0;
                    return z;
                } else if (a.real > 0) {
                    r = a.real;
                    theta = 0;
                } else {
                    r = -a.real;
                    theta = atan2f(0.0, -1.0);
                }
            } else {
                r = __Pyx_c_abs_float(a);
                theta = atan2f(a.imag, a.real);
            }
            lnr = logf(r);
            z_r = expf(lnr * b.real - theta * b.imag);
            z_theta = theta * b.real + lnr * b.imag;
            z.real = z_r * cosf(z_theta);
            z.imag = z_r * sinf(z_theta);
            return z;
        }
    #endif
#endif

/* Declarations */
    #if CYTHON_CCOMPLEX
  #ifdef __cplusplus
    static CYTHON_INLINE __pyx_t_double_complex __pyx_t_double_complex_from_parts(double x, double y) {
      return ::std::complex< double >(x, y);
    }
  #else
    static CYTHON_INLINE __pyx_t_double_complex __pyx_t_double_complex_from_parts(double x, double y) {
      return x + y*(__pyx_t_double_complex)_Complex_I;
    }
  #endif
#else
    static CYTHON_INLINE __pyx_t_double_complex __pyx_t_double_complex_from_parts(double x, double y) {
      __pyx_t_double_complex z;
      z.real = x;
      z.imag = y;
      return z;
    }
#endif

/* Arithmetic */
    #if CYTHON_CCOMPLEX
#else
    static CYTHON_INLINE int __Pyx_c_eq_double(__pyx_t_double_complex a, __pyx_t_double_complex b) {
       return (a.real == b.real) && (a.imag == b.imag);
    }
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_sum_double(__pyx_t_double_complex a, __pyx_t_double_complex b) {
        __pyx_t_double_complex z;
        z.real = a.real + b.real;
        z.imag = a.imag + b.imag;
        return z;
    }
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_diff_double(__pyx_t_double_complex a, __pyx_t_double_complex b) {
        __pyx_t_double_complex z;
        z.real = a.real - b.real;
        z.imag = a.imag - b.imag;
        return z;
    }
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_prod_double(__pyx_t_double_complex a, __pyx_t_double_complex b) {
        __pyx_t_double_complex z;
        z.real = a.real * b.real - a.imag * b.imag;
        z.imag = a.real * b.imag + a.imag * b.real;
        return z;
    }
    #if 1
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_quot_double(__pyx_t_double_complex a, __pyx_t_double_complex b) {
        if (b.imag == 0) {
            return __pyx_t_double_complex_from_parts(a.real / b.real, a.imag / b.real);
        } else if (fabs(b.real) >= fabs(b.imag)) {
            if (b.real == 0 && b.imag == 0) {
                return __pyx_t_double_complex_from_parts(a.real / b.real, a.imag / b.imag);
            } else {
                double r = b.imag / b.real;
                double s = (double)(1.0) / (b.real + b.imag * r);
                return __pyx_t_double_complex_from_parts(
                    (a.real + a.imag * r) * s, (a.imag - a.real * r) * s);
            }
        } else {
            double r = b.real / b.imag;
            double s = (double)(1.0) / (b.imag + b.real * r);
            return __pyx_t_double_complex_from_parts(
                (a.real * r + a.imag) * s, (a.imag * r - a.real) * s);
        }
    }
    #else
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_quot_double(__pyx_t_double_complex a, __pyx_t_double_complex b) {
        if (b.imag == 0) {
            return __pyx_t_double_complex_from_parts(a.real / b.real, a.imag / b.real);
        } else {
            double denom = b.real * b.real + b.imag * b.imag;
            return __pyx_t_double_complex_from_parts(
                (a.real * b.real + a.imag * b.imag) / denom,
                (a.imag * b.real - a.real * b.imag) / denom);
        }
    }
    #endif
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_neg_double(__pyx_t_double_complex a) {
        __pyx_t_double_complex z;
        z.real = -a.real;
        z.imag = -a.imag;
        return z;
    }
    static CYTHON_INLINE int __Pyx_c_is_zero_double(__pyx_t_double_complex a) {
       return (a.real == 0) && (a.imag == 0);
    }
    static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_conj_double(__pyx_t_double_complex a) {
        __pyx_t_double_complex z;
        z.real =  a.real;
        z.imag = -a.imag;
        return z;
    }
    #if 1
        static CYTHON_INLINE double __Pyx_c_abs_double(__pyx_t_double_complex z) {
          #if !defined(HAVE_HYPOT) || defined(_MSC_VER)
            return sqrt(z.real*z.real + z.imag*z.imag);
          #else
            return hypot(z.real, z.imag);
          #endif
        }
        static CYTHON_INLINE __pyx_t_double_complex __Pyx_c_pow_double(__pyx_t_double_complex a, __pyx_t_double_complex b) {
            __pyx_t_double_complex z;
            double r, lnr, theta, z_r, z_theta;
            if (b.imag == 0 && b.real == (int)b.real) {
                if (b.real < 0) {
                    double denom = a.real * a.real + a.imag * a.imag;
                    a.real = a.real / denom;
                    a.imag = -a.imag / denom;
                    b.real = -b.real;
                }
                switch ((int)b.real) {
                    case 0:
                        z.real = 1;
                        z.imag = 0;
                        return z;
                    case 1:
                        return a;
                    case 2:
                        return __Pyx_c_prod_double(a, a);
                    case 3:
                        z = __Pyx_c_prod_double(a, a);
                        return __Pyx_c_prod_double(z, a);
                    case 4:
                        z = __Pyx_c_prod_double(a, a);
                        return __Pyx_c_prod_double(z, z);
                }
            }
            if (a.imag == 0) {
                if (a.real == 0) {
                    return a;
                } else if (b.imag == 0) {
                    z.real = pow(a.real, b.real);
                    z.imag = 0;
                    return z;
                } else if (a.real > 0) {
                    r = a.real;
                    theta = 0;
                } else {
                    r = -a.real;
                    theta = atan2(0.0, -1.0);
                }
            } else {
                r = __Pyx_c_abs_double(a);
                theta = atan2(a.imag, a.real);
            }
            lnr = log(r);
            z_r = exp(lnr * b.real - theta * b.imag);
            z_theta = theta * b.real + lnr * b.imag;
            z.real = z_r * cos(z_theta);
            z.imag = z_r * sin(z_theta);
            return z;
        }
    #endif
#endif

/* CIntToPy */
    static CYTHON_INLINE PyObject* __Pyx_PyInt_From_int(int value) {
    const int neg_one = (int) ((int) 0 - (int) 1), const_zero = (int) 0;
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(int) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(int) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(int) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(int) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(int) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
        return _PyLong_FromByteArray(bytes, sizeof(int),
                                     little, !is_unsigned);
    }
}

/* CIntToPy */
    static CYTHON_INLINE PyObject* __Pyx_PyInt_From_enum__NPY_TYPES(enum NPY_TYPES value) {
    const enum NPY_TYPES neg_one = (enum NPY_TYPES) ((enum NPY_TYPES) 0 - (enum NPY_TYPES) 1), const_zero = (enum NPY_TYPES) 0;
    const int is_unsigned = neg_one > const_zero;
    if (is_unsigned) {
        if (sizeof(enum NPY_TYPES) < sizeof(long)) {
            return PyInt_FromLong((long) value);
        } else if (sizeof(enum NPY_TYPES) <= sizeof(unsigned long)) {
            return PyLong_FromUnsignedLong((unsigned long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(enum NPY_TYPES) <= sizeof(unsigned PY_LONG_LONG)) {
            return PyLong_FromUnsignedLongLong((unsigned PY_LONG_LONG) value);
#endif
        }
    } else {
        if (sizeof(enum NPY_TYPES) <= sizeof(long)) {
            return PyInt_FromLong((long) value);
#ifdef HAVE_LONG_LONG
        } else if (sizeof(enum NPY_TYPES) <= sizeof(PY_LONG_LONG)) {
            return PyLong_FromLongLong((PY_LONG_LONG) value);
#endif
        }
    }
    {
        int one = 1; int little = (int)*(unsigned char *)&one;
        unsigned char *bytes = (unsigned char *)&value;
        return _PyLong_FromByteArray(bytes, sizeof(enum NPY_TYPES),
                                     little, !is_unsigned);
    }
}

/* CIntFromPy */
    static CYTHON_INLINE npy_int32 __Pyx_PyInt_As_npy_int32(PyObject *x) {
    const npy_int32 neg_one = (npy_int32) ((npy_int32) 0 - (npy_int32) 1), const_zero = (npy_int32) 0;
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if (sizeof(npy_int32) < sizeof(long)) {
            __PYX_VERIFY_RETURN_INT(npy_int32, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (npy_int32) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (npy_int32) 0;
                case  1: __PYX_VERIFY_RETURN_INT(npy_int32, digit, digits[0])
                case 2:
                    if (8 * sizeof(npy_int32) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) >= 2 * PyLong_SHIFT) {
                            return (npy_int32) (((((npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0]));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(npy_int32) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) >= 3 * PyLong_SHIFT) {
                            return (npy_int32) (((((((npy_int32)digits[2]) << PyLong_SHIFT) | (npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0]));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(npy_int32) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) >= 4 * PyLong_SHIFT) {
                            return (npy_int32) (((((((((npy_int32)digits[3]) << PyLong_SHIFT) | (npy_int32)digits[2]) << PyLong_SHIFT) | (npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0]));
                        }
                    }
                    break;
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (npy_int32) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if (sizeof(npy_int32) <= sizeof(unsigned long)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int32, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(npy_int32) <= sizeof(unsigned PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int32, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (npy_int32) 0;
                case -1: __PYX_VERIFY_RETURN_INT(npy_int32, sdigit, (sdigit) (-(sdigit)digits[0]))
                case  1: __PYX_VERIFY_RETURN_INT(npy_int32,  digit, +digits[0])
                case -2:
                    if (8 * sizeof(npy_int32) - 1 > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) - 1 > 2 * PyLong_SHIFT) {
                            return (npy_int32) (((npy_int32)-1)*(((((npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0])));
                        }
                    }
                    break;
                case 2:
                    if (8 * sizeof(npy_int32) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) - 1 > 2 * PyLong_SHIFT) {
                            return (npy_int32) ((((((npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0])));
                        }
                    }
                    break;
                case -3:
                    if (8 * sizeof(npy_int32) - 1 > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) - 1 > 3 * PyLong_SHIFT) {
                            return (npy_int32) (((npy_int32)-1)*(((((((npy_int32)digits[2]) << PyLong_SHIFT) | (npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0])));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(npy_int32) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) - 1 > 3 * PyLong_SHIFT) {
                            return (npy_int32) ((((((((npy_int32)digits[2]) << PyLong_SHIFT) | (npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0])));
                        }
                    }
                    break;
                case -4:
                    if (8 * sizeof(npy_int32) - 1 > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) - 1 > 4 * PyLong_SHIFT) {
                            return (npy_int32) (((npy_int32)-1)*(((((((((npy_int32)digits[3]) << PyLong_SHIFT) | (npy_int32)digits[2]) << PyLong_SHIFT) | (npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0])));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(npy_int32) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int32, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int32) - 1 > 4 * PyLong_SHIFT) {
                            return (npy_int32) ((((((((((npy_int32)digits[3]) << PyLong_SHIFT) | (npy_int32)digits[2]) << PyLong_SHIFT) | (npy_int32)digits[1]) << PyLong_SHIFT) | (npy_int32)digits[0])));
                        }
                    }
                    break;
            }
#endif
            if (sizeof(npy_int32) <= sizeof(long)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int32, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(npy_int32) <= sizeof(PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int32, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
#if CYTHON_COMPILING_IN_PYPY && !defined(_PyLong_AsByteArray)
            PyErr_SetString(PyExc_RuntimeError,
                            "_PyLong_AsByteArray() not available in PyPy, cannot convert large numbers");
#else
            npy_int32 val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
 #if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
 #endif
            if (likely(v)) {
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                int ret = _PyLong_AsByteArray((PyLongObject *)v,
                                              bytes, sizeof(val),
                                              is_little, !is_unsigned);
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
#endif
            return (npy_int32) -1;
        }
    } else {
        npy_int32 val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (npy_int32) -1;
        val = __Pyx_PyInt_As_npy_int32(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to npy_int32");
    return (npy_int32) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to npy_int32");
    return (npy_int32) -1;
}

/* CIntFromPy */
    static CYTHON_INLINE npy_int64 __Pyx_PyInt_As_npy_int64(PyObject *x) {
    const npy_int64 neg_one = (npy_int64) ((npy_int64) 0 - (npy_int64) 1), const_zero = (npy_int64) 0;
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if (sizeof(npy_int64) < sizeof(long)) {
            __PYX_VERIFY_RETURN_INT(npy_int64, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (npy_int64) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (npy_int64) 0;
                case  1: __PYX_VERIFY_RETURN_INT(npy_int64, digit, digits[0])
                case 2:
                    if (8 * sizeof(npy_int64) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) >= 2 * PyLong_SHIFT) {
                            return (npy_int64) (((((npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0]));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(npy_int64) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) >= 3 * PyLong_SHIFT) {
                            return (npy_int64) (((((((npy_int64)digits[2]) << PyLong_SHIFT) | (npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0]));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(npy_int64) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) >= 4 * PyLong_SHIFT) {
                            return (npy_int64) (((((((((npy_int64)digits[3]) << PyLong_SHIFT) | (npy_int64)digits[2]) << PyLong_SHIFT) | (npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0]));
                        }
                    }
                    break;
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (npy_int64) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if (sizeof(npy_int64) <= sizeof(unsigned long)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int64, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(npy_int64) <= sizeof(unsigned PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int64, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (npy_int64) 0;
                case -1: __PYX_VERIFY_RETURN_INT(npy_int64, sdigit, (sdigit) (-(sdigit)digits[0]))
                case  1: __PYX_VERIFY_RETURN_INT(npy_int64,  digit, +digits[0])
                case -2:
                    if (8 * sizeof(npy_int64) - 1 > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) - 1 > 2 * PyLong_SHIFT) {
                            return (npy_int64) (((npy_int64)-1)*(((((npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0])));
                        }
                    }
                    break;
                case 2:
                    if (8 * sizeof(npy_int64) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) - 1 > 2 * PyLong_SHIFT) {
                            return (npy_int64) ((((((npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0])));
                        }
                    }
                    break;
                case -3:
                    if (8 * sizeof(npy_int64) - 1 > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) - 1 > 3 * PyLong_SHIFT) {
                            return (npy_int64) (((npy_int64)-1)*(((((((npy_int64)digits[2]) << PyLong_SHIFT) | (npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0])));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(npy_int64) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) - 1 > 3 * PyLong_SHIFT) {
                            return (npy_int64) ((((((((npy_int64)digits[2]) << PyLong_SHIFT) | (npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0])));
                        }
                    }
                    break;
                case -4:
                    if (8 * sizeof(npy_int64) - 1 > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) - 1 > 4 * PyLong_SHIFT) {
                            return (npy_int64) (((npy_int64)-1)*(((((((((npy_int64)digits[3]) << PyLong_SHIFT) | (npy_int64)digits[2]) << PyLong_SHIFT) | (npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0])));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(npy_int64) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(npy_int64, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(npy_int64) - 1 > 4 * PyLong_SHIFT) {
                            return (npy_int64) ((((((((((npy_int64)digits[3]) << PyLong_SHIFT) | (npy_int64)digits[2]) << PyLong_SHIFT) | (npy_int64)digits[1]) << PyLong_SHIFT) | (npy_int64)digits[0])));
                        }
                    }
                    break;
            }
#endif
            if (sizeof(npy_int64) <= sizeof(long)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int64, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(npy_int64) <= sizeof(PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(npy_int64, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
#if CYTHON_COMPILING_IN_PYPY && !defined(_PyLong_AsByteArray)
            PyErr_SetString(PyExc_RuntimeError,
                            "_PyLong_AsByteArray() not available in PyPy, cannot convert large numbers");
#else
            npy_int64 val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
 #if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
 #endif
            if (likely(v)) {
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                int ret = _PyLong_AsByteArray((PyLongObject *)v,
                                              bytes, sizeof(val),
                                              is_little, !is_unsigned);
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
#endif
            return (npy_int64) -1;
        }
    } else {
        npy_int64 val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (npy_int64) -1;
        val = __Pyx_PyInt_As_npy_int64(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to npy_int64");
    return (npy_int64) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to npy_int64");
    return (npy_int64) -1;
}

/* CIntFromPy */
    static CYTHON_INLINE long __Pyx_PyInt_As_long(PyObject *x) {
    const long neg_one = (long) ((long) 0 - (long) 1), const_zero = (long) 0;
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if (sizeof(long) < sizeof(long)) {
            __PYX_VERIFY_RETURN_INT(long, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (long) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (long) 0;
                case  1: __PYX_VERIFY_RETURN_INT(long, digit, digits[0])
                case 2:
                    if (8 * sizeof(long) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) >= 2 * PyLong_SHIFT) {
                            return (long) (((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(long) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) >= 3 * PyLong_SHIFT) {
                            return (long) (((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(long) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) >= 4 * PyLong_SHIFT) {
                            return (long) (((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0]));
                        }
                    }
                    break;
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (long) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if (sizeof(long) <= sizeof(unsigned long)) {
                __PYX_VERIFY_RETURN_INT_EXC(long, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(long) <= sizeof(unsigned PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(long, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (long) 0;
                case -1: __PYX_VERIFY_RETURN_INT(long, sdigit, (sdigit) (-(sdigit)digits[0]))
                case  1: __PYX_VERIFY_RETURN_INT(long,  digit, +digits[0])
                case -2:
                    if (8 * sizeof(long) - 1 > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                            return (long) (((long)-1)*(((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                        }
                    }
                    break;
                case 2:
                    if (8 * sizeof(long) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                            return (long) ((((((long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                        }
                    }
                    break;
                case -3:
                    if (8 * sizeof(long) - 1 > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                            return (long) (((long)-1)*(((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(long) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                            return (long) ((((((((long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                        }
                    }
                    break;
                case -4:
                    if (8 * sizeof(long) - 1 > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                            return (long) (((long)-1)*(((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(long) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(long, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(long) - 1 > 4 * PyLong_SHIFT) {
                            return (long) ((((((((((long)digits[3]) << PyLong_SHIFT) | (long)digits[2]) << PyLong_SHIFT) | (long)digits[1]) << PyLong_SHIFT) | (long)digits[0])));
                        }
                    }
                    break;
            }
#endif
            if (sizeof(long) <= sizeof(long)) {
                __PYX_VERIFY_RETURN_INT_EXC(long, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(long) <= sizeof(PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(long, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
#if CYTHON_COMPILING_IN_PYPY && !defined(_PyLong_AsByteArray)
            PyErr_SetString(PyExc_RuntimeError,
                            "_PyLong_AsByteArray() not available in PyPy, cannot convert large numbers");
#else
            long val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
 #if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
 #endif
            if (likely(v)) {
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                int ret = _PyLong_AsByteArray((PyLongObject *)v,
                                              bytes, sizeof(val),
                                              is_little, !is_unsigned);
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
#endif
            return (long) -1;
        }
    } else {
        long val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (long) -1;
        val = __Pyx_PyInt_As_long(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to long");
    return (long) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to long");
    return (long) -1;
}

/* CIntFromPy */
    static CYTHON_INLINE int __Pyx_PyInt_As_int(PyObject *x) {
    const int neg_one = (int) ((int) 0 - (int) 1), const_zero = (int) 0;
    const int is_unsigned = neg_one > const_zero;
#if PY_MAJOR_VERSION < 3
    if (likely(PyInt_Check(x))) {
        if (sizeof(int) < sizeof(long)) {
            __PYX_VERIFY_RETURN_INT(int, long, PyInt_AS_LONG(x))
        } else {
            long val = PyInt_AS_LONG(x);
            if (is_unsigned && unlikely(val < 0)) {
                goto raise_neg_overflow;
            }
            return (int) val;
        }
    } else
#endif
    if (likely(PyLong_Check(x))) {
        if (is_unsigned) {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (int) 0;
                case  1: __PYX_VERIFY_RETURN_INT(int, digit, digits[0])
                case 2:
                    if (8 * sizeof(int) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) >= 2 * PyLong_SHIFT) {
                            return (int) (((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(int) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) >= 3 * PyLong_SHIFT) {
                            return (int) (((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(int) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) >= 4 * PyLong_SHIFT) {
                            return (int) (((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0]));
                        }
                    }
                    break;
            }
#endif
#if CYTHON_COMPILING_IN_CPYTHON
            if (unlikely(Py_SIZE(x) < 0)) {
                goto raise_neg_overflow;
            }
#else
            {
                int result = PyObject_RichCompareBool(x, Py_False, Py_LT);
                if (unlikely(result < 0))
                    return (int) -1;
                if (unlikely(result == 1))
                    goto raise_neg_overflow;
            }
#endif
            if (sizeof(int) <= sizeof(unsigned long)) {
                __PYX_VERIFY_RETURN_INT_EXC(int, unsigned long, PyLong_AsUnsignedLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(int) <= sizeof(unsigned PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(int, unsigned PY_LONG_LONG, PyLong_AsUnsignedLongLong(x))
#endif
            }
        } else {
#if CYTHON_USE_PYLONG_INTERNALS
            const digit* digits = ((PyLongObject*)x)->ob_digit;
            switch (Py_SIZE(x)) {
                case  0: return (int) 0;
                case -1: __PYX_VERIFY_RETURN_INT(int, sdigit, (sdigit) (-(sdigit)digits[0]))
                case  1: __PYX_VERIFY_RETURN_INT(int,  digit, +digits[0])
                case -2:
                    if (8 * sizeof(int) - 1 > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, long, -(long) (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) - 1 > 2 * PyLong_SHIFT) {
                            return (int) (((int)-1)*(((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                        }
                    }
                    break;
                case 2:
                    if (8 * sizeof(int) > 1 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 2 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) - 1 > 2 * PyLong_SHIFT) {
                            return (int) ((((((int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                        }
                    }
                    break;
                case -3:
                    if (8 * sizeof(int) - 1 > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, long, -(long) (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) - 1 > 3 * PyLong_SHIFT) {
                            return (int) (((int)-1)*(((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                        }
                    }
                    break;
                case 3:
                    if (8 * sizeof(int) > 2 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 3 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) - 1 > 3 * PyLong_SHIFT) {
                            return (int) ((((((((int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                        }
                    }
                    break;
                case -4:
                    if (8 * sizeof(int) - 1 > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, long, -(long) (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) - 1 > 4 * PyLong_SHIFT) {
                            return (int) (((int)-1)*(((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                        }
                    }
                    break;
                case 4:
                    if (8 * sizeof(int) > 3 * PyLong_SHIFT) {
                        if (8 * sizeof(unsigned long) > 4 * PyLong_SHIFT) {
                            __PYX_VERIFY_RETURN_INT(int, unsigned long, (((((((((unsigned long)digits[3]) << PyLong_SHIFT) | (unsigned long)digits[2]) << PyLong_SHIFT) | (unsigned long)digits[1]) << PyLong_SHIFT) | (unsigned long)digits[0])))
                        } else if (8 * sizeof(int) - 1 > 4 * PyLong_SHIFT) {
                            return (int) ((((((((((int)digits[3]) << PyLong_SHIFT) | (int)digits[2]) << PyLong_SHIFT) | (int)digits[1]) << PyLong_SHIFT) | (int)digits[0])));
                        }
                    }
                    break;
            }
#endif
            if (sizeof(int) <= sizeof(long)) {
                __PYX_VERIFY_RETURN_INT_EXC(int, long, PyLong_AsLong(x))
#ifdef HAVE_LONG_LONG
            } else if (sizeof(int) <= sizeof(PY_LONG_LONG)) {
                __PYX_VERIFY_RETURN_INT_EXC(int, PY_LONG_LONG, PyLong_AsLongLong(x))
#endif
            }
        }
        {
#if CYTHON_COMPILING_IN_PYPY && !defined(_PyLong_AsByteArray)
            PyErr_SetString(PyExc_RuntimeError,
                            "_PyLong_AsByteArray() not available in PyPy, cannot convert large numbers");
#else
            int val;
            PyObject *v = __Pyx_PyNumber_IntOrLong(x);
 #if PY_MAJOR_VERSION < 3
            if (likely(v) && !PyLong_Check(v)) {
                PyObject *tmp = v;
                v = PyNumber_Long(tmp);
                Py_DECREF(tmp);
            }
 #endif
            if (likely(v)) {
                int one = 1; int is_little = (int)*(unsigned char *)&one;
                unsigned char *bytes = (unsigned char *)&val;
                int ret = _PyLong_AsByteArray((PyLongObject *)v,
                                              bytes, sizeof(val),
                                              is_little, !is_unsigned);
                Py_DECREF(v);
                if (likely(!ret))
                    return val;
            }
#endif
            return (int) -1;
        }
    } else {
        int val;
        PyObject *tmp = __Pyx_PyNumber_IntOrLong(x);
        if (!tmp) return (int) -1;
        val = __Pyx_PyInt_As_int(tmp);
        Py_DECREF(tmp);
        return val;
    }
raise_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "value too large to convert to int");
    return (int) -1;
raise_neg_overflow:
    PyErr_SetString(PyExc_OverflowError,
        "can't convert negative value to int");
    return (int) -1;
}

/* FastTypeChecks */
    #if CYTHON_COMPILING_IN_CPYTHON
static int __Pyx_InBases(PyTypeObject *a, PyTypeObject *b) {
    while (a) {
        a = a->tp_base;
        if (a == b)
            return 1;
    }
    return b == &PyBaseObject_Type;
}
static CYTHON_INLINE int __Pyx_IsSubtype(PyTypeObject *a, PyTypeObject *b) {
    PyObject *mro;
    if (a == b) return 1;
    mro = a->tp_mro;
    if (likely(mro)) {
        Py_ssize_t i, n;
        n = PyTuple_GET_SIZE(mro);
        for (i = 0; i < n; i++) {
            if (PyTuple_GET_ITEM(mro, i) == (PyObject *)b)
                return 1;
        }
        return 0;
    }
    return __Pyx_InBases(a, b);
}
#if PY_MAJOR_VERSION == 2
static int __Pyx_inner_PyErr_GivenExceptionMatches2(PyObject *err, PyObject* exc_type1, PyObject* exc_type2) {
    PyObject *exception, *value, *tb;
    int res;
    __Pyx_PyThreadState_declare
    __Pyx_PyThreadState_assign
    __Pyx_ErrFetch(&exception, &value, &tb);
    res = exc_type1 ? PyObject_IsSubclass(err, exc_type1) : 0;
    if (unlikely(res == -1)) {
        PyErr_WriteUnraisable(err);
        res = 0;
    }
    if (!res) {
        res = PyObject_IsSubclass(err, exc_type2);
        if (unlikely(res == -1)) {
            PyErr_WriteUnraisable(err);
            res = 0;
        }
    }
    __Pyx_ErrRestore(exception, value, tb);
    return res;
}
#else
static CYTHON_INLINE int __Pyx_inner_PyErr_GivenExceptionMatches2(PyObject *err, PyObject* exc_type1, PyObject *exc_type2) {
    int res = exc_type1 ? __Pyx_IsSubtype((PyTypeObject*)err, (PyTypeObject*)exc_type1) : 0;
    if (!res) {
        res = __Pyx_IsSubtype((PyTypeObject*)err, (PyTypeObject*)exc_type2);
    }
    return res;
}
#endif
static int __Pyx_PyErr_GivenExceptionMatchesTuple(PyObject *exc_type, PyObject *tuple) {
    Py_ssize_t i, n;
    assert(PyExceptionClass_Check(exc_type));
    n = PyTuple_GET_SIZE(tuple);
#if PY_MAJOR_VERSION >= 3
    for (i=0; i<n; i++) {
        if (exc_type == PyTuple_GET_ITEM(tuple, i)) return 1;
    }
#endif
    for (i=0; i<n; i++) {
        PyObject *t = PyTuple_GET_ITEM(tuple, i);
        #if PY_MAJOR_VERSION < 3
        if (likely(exc_type == t)) return 1;
        #endif
        if (likely(PyExceptionClass_Check(t))) {
            if (__Pyx_inner_PyErr_GivenExceptionMatches2(exc_type, NULL, t)) return 1;
        } else {
        }
    }
    return 0;
}
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches(PyObject *err, PyObject* exc_type) {
    if (likely(err == exc_type)) return 1;
    if (likely(PyExceptionClass_Check(err))) {
        if (likely(PyExceptionClass_Check(exc_type))) {
            return __Pyx_inner_PyErr_GivenExceptionMatches2(err, NULL, exc_type);
        } else if (likely(PyTuple_Check(exc_type))) {
            return __Pyx_PyErr_GivenExceptionMatchesTuple(err, exc_type);
        } else {
        }
    }
    return PyErr_GivenExceptionMatches(err, exc_type);
}
static CYTHON_INLINE int __Pyx_PyErr_GivenExceptionMatches2(PyObject *err, PyObject *exc_type1, PyObject *exc_type2) {
    assert(PyExceptionClass_Check(exc_type1));
    assert(PyExceptionClass_Check(exc_type2));
    if (likely(err == exc_type1 || err == exc_type2)) return 1;
    if (likely(PyExceptionClass_Check(err))) {
        return __Pyx_inner_PyErr_GivenExceptionMatches2(err, exc_type1, exc_type2);
    }
    return (PyErr_GivenExceptionMatches(err, exc_type1) || PyErr_GivenExceptionMatches(err, exc_type2));
}
#endif

/* CheckBinaryVersion */
    static int __Pyx_check_binary_version(void) {
    char ctversion[4], rtversion[4];
    PyOS_snprintf(ctversion, 4, "%d.%d", PY_MAJOR_VERSION, PY_MINOR_VERSION);
    PyOS_snprintf(rtversion, 4, "%s", Py_GetVersion());
    if (ctversion[0] != rtversion[0] || ctversion[2] != rtversion[2]) {
        char message[200];
        PyOS_snprintf(message, sizeof(message),
                      "compiletime version %s of module '%.100s' "
                      "does not match runtime version %s",
                      ctversion, __Pyx_MODULE_NAME, rtversion);
        return PyErr_WarnEx(NULL, message, 1);
    }
    return 0;
}

/* InitStrings */
    static int __Pyx_InitStrings(__Pyx_StringTabEntry *t) {
    while (t->p) {
        #if PY_MAJOR_VERSION < 3
        if (t->is_unicode) {
            *t->p = PyUnicode_DecodeUTF8(t->s, t->n - 1, NULL);
        } else if (t->intern) {
            *t->p = PyString_InternFromString(t->s);
        } else {
            *t->p = PyString_FromStringAndSize(t->s, t->n - 1);
        }
        #else
        if (t->is_unicode | t->is_str) {
            if (t->intern) {
                *t->p = PyUnicode_InternFromString(t->s);
            } else if (t->encoding) {
                *t->p = PyUnicode_Decode(t->s, t->n - 1, t->encoding, NULL);
            } else {
                *t->p = PyUnicode_FromStringAndSize(t->s, t->n - 1);
            }
        } else {
            *t->p = PyBytes_FromStringAndSize(t->s, t->n - 1);
        }
        #endif
        if (!*t->p)
            return -1;
        if (PyObject_Hash(*t->p) == -1)
            return -1;
        ++t;
    }
    return 0;
}

static CYTHON_INLINE PyObject* __Pyx_PyUnicode_FromString(const char* c_str) {
    return __Pyx_PyUnicode_FromStringAndSize(c_str, (Py_ssize_t)strlen(c_str));
}
static CYTHON_INLINE const char* __Pyx_PyObject_AsString(PyObject* o) {
    Py_ssize_t ignore;
    return __Pyx_PyObject_AsStringAndSize(o, &ignore);
}
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
#if !CYTHON_PEP393_ENABLED
static const char* __Pyx_PyUnicode_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
    char* defenc_c;
    PyObject* defenc = _PyUnicode_AsDefaultEncodedString(o, NULL);
    if (!defenc) return NULL;
    defenc_c = PyBytes_AS_STRING(defenc);
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
    {
        char* end = defenc_c + PyBytes_GET_SIZE(defenc);
        char* c;
        for (c = defenc_c; c < end; c++) {
            if ((unsigned char) (*c) >= 128) {
                PyUnicode_AsASCIIString(o);
                return NULL;
            }
        }
    }
#endif
    *length = PyBytes_GET_SIZE(defenc);
    return defenc_c;
}
#else
static CYTHON_INLINE const char* __Pyx_PyUnicode_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
    if (unlikely(__Pyx_PyUnicode_READY(o) == -1)) return NULL;
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
    if (likely(PyUnicode_IS_ASCII(o))) {
        *length = PyUnicode_GET_LENGTH(o);
        return PyUnicode_AsUTF8(o);
    } else {
        PyUnicode_AsASCIIString(o);
        return NULL;
    }
#else
    return PyUnicode_AsUTF8AndSize(o, length);
#endif
}
#endif
#endif
static CYTHON_INLINE const char* __Pyx_PyObject_AsStringAndSize(PyObject* o, Py_ssize_t *length) {
#if __PYX_DEFAULT_STRING_ENCODING_IS_ASCII || __PYX_DEFAULT_STRING_ENCODING_IS_DEFAULT
    if (
#if PY_MAJOR_VERSION < 3 && __PYX_DEFAULT_STRING_ENCODING_IS_ASCII
            __Pyx_sys_getdefaultencoding_not_ascii &&
#endif
            PyUnicode_Check(o)) {
        return __Pyx_PyUnicode_AsStringAndSize(o, length);
    } else
#endif
#if (!CYTHON_COMPILING_IN_PYPY) || (defined(PyByteArray_AS_STRING) && defined(PyByteArray_GET_SIZE))
    if (PyByteArray_Check(o)) {
        *length = PyByteArray_GET_SIZE(o);
        return PyByteArray_AS_STRING(o);
    } else
#endif
    {
        char* result;
        int r = PyBytes_AsStringAndSize(o, &result, length);
        if (unlikely(r < 0)) {
            return NULL;
        } else {
            return result;
        }
    }
}
static CYTHON_INLINE int __Pyx_PyObject_IsTrue(PyObject* x) {
   int is_true = x == Py_True;
   if (is_true | (x == Py_False) | (x == Py_None)) return is_true;
   else return PyObject_IsTrue(x);
}
static CYTHON_INLINE int __Pyx_PyObject_IsTrueAndDecref(PyObject* x) {
    int retval;
    if (unlikely(!x)) return -1;
    retval = __Pyx_PyObject_IsTrue(x);
    Py_DECREF(x);
    return retval;
}
static PyObject* __Pyx_PyNumber_IntOrLongWrongResultType(PyObject* result, const char* type_name) {
#if PY_MAJOR_VERSION >= 3
    if (PyLong_Check(result)) {
        if (PyErr_WarnFormat(PyExc_DeprecationWarning, 1,
                "__int__ returned non-int (type %.200s).  "
                "The ability to return an instance of a strict subclass of int "
                "is deprecated, and may be removed in a future version of Python.",
                Py_TYPE(result)->tp_name)) {
            Py_DECREF(result);
            return NULL;
        }
        return result;
    }
#endif
    PyErr_Format(PyExc_TypeError,
                 "__%.4s__ returned non-%.4s (type %.200s)",
                 type_name, type_name, Py_TYPE(result)->tp_name);
    Py_DECREF(result);
    return NULL;
}
static CYTHON_INLINE PyObject* __Pyx_PyNumber_IntOrLong(PyObject* x) {
#if CYTHON_USE_TYPE_SLOTS
  PyNumberMethods *m;
#endif
  const char *name = NULL;
  PyObject *res = NULL;
#if PY_MAJOR_VERSION < 3
  if (likely(PyInt_Check(x) || PyLong_Check(x)))
#else
  if (likely(PyLong_Check(x)))
#endif
    return __Pyx_NewRef(x);
#if CYTHON_USE_TYPE_SLOTS
  m = Py_TYPE(x)->tp_as_number;
  #if PY_MAJOR_VERSION < 3
  if (m && m->nb_int) {
    name = "int";
    res = m->nb_int(x);
  }
  else if (m && m->nb_long) {
    name = "long";
    res = m->nb_long(x);
  }
  #else
  if (likely(m && m->nb_int)) {
    name = "int";
    res = m->nb_int(x);
  }
  #endif
#else
  if (!PyBytes_CheckExact(x) && !PyUnicode_CheckExact(x)) {
    res = PyNumber_Int(x);
  }
#endif
  if (likely(res)) {
#if PY_MAJOR_VERSION < 3
    if (unlikely(!PyInt_Check(res) && !PyLong_Check(res))) {
#else
    if (unlikely(!PyLong_CheckExact(res))) {
#endif
        return __Pyx_PyNumber_IntOrLongWrongResultType(res, name);
    }
  }
  else if (!PyErr_Occurred()) {
    PyErr_SetString(PyExc_TypeError,
                    "an integer is required");
  }
  return res;
}
static CYTHON_INLINE Py_ssize_t __Pyx_PyIndex_AsSsize_t(PyObject* b) {
  Py_ssize_t ival;
  PyObject *x;
#if PY_MAJOR_VERSION < 3
  if (likely(PyInt_CheckExact(b))) {
    if (sizeof(Py_ssize_t) >= sizeof(long))
        return PyInt_AS_LONG(b);
    else
        return PyInt_AsSsize_t(b);
  }
#endif
  if (likely(PyLong_CheckExact(b))) {
    #if CYTHON_USE_PYLONG_INTERNALS
    const digit* digits = ((PyLongObject*)b)->ob_digit;
    const Py_ssize_t size = Py_SIZE(b);
    if (likely(__Pyx_sst_abs(size) <= 1)) {
        ival = likely(size) ? digits[0] : 0;
        if (size == -1) ival = -ival;
        return ival;
    } else {
      switch (size) {
         case 2:
           if (8 * sizeof(Py_ssize_t) > 2 * PyLong_SHIFT) {
             return (Py_ssize_t) (((((size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case -2:
           if (8 * sizeof(Py_ssize_t) > 2 * PyLong_SHIFT) {
             return -(Py_ssize_t) (((((size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case 3:
           if (8 * sizeof(Py_ssize_t) > 3 * PyLong_SHIFT) {
             return (Py_ssize_t) (((((((size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case -3:
           if (8 * sizeof(Py_ssize_t) > 3 * PyLong_SHIFT) {
             return -(Py_ssize_t) (((((((size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case 4:
           if (8 * sizeof(Py_ssize_t) > 4 * PyLong_SHIFT) {
             return (Py_ssize_t) (((((((((size_t)digits[3]) << PyLong_SHIFT) | (size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
         case -4:
           if (8 * sizeof(Py_ssize_t) > 4 * PyLong_SHIFT) {
             return -(Py_ssize_t) (((((((((size_t)digits[3]) << PyLong_SHIFT) | (size_t)digits[2]) << PyLong_SHIFT) | (size_t)digits[1]) << PyLong_SHIFT) | (size_t)digits[0]));
           }
           break;
      }
    }
    #endif
    return PyLong_AsSsize_t(b);
  }
  x = PyNumber_Index(b);
  if (!x) return -1;
  ival = PyInt_AsSsize_t(x);
  Py_DECREF(x);
  return ival;
}
static CYTHON_INLINE PyObject * __Pyx_PyBool_FromLong(long b) {
  return b ? __Pyx_NewRef(Py_True) : __Pyx_NewRef(Py_False);
}
static CYTHON_INLINE PyObject * __Pyx_PyInt_FromSize_t(size_t ival) {
    return PyInt_FromSize_t(ival);
}


#endif /* Py_PYTHON_H */
